JP2010515693A5 - - Google Patents

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JP2010515693A5
JP2010515693A5 JP2009545043A JP2009545043A JP2010515693A5 JP 2010515693 A5 JP2010515693 A5 JP 2010515693A5 JP 2009545043 A JP2009545043 A JP 2009545043A JP 2009545043 A JP2009545043 A JP 2009545043A JP 2010515693 A5 JP2010515693 A5 JP 2010515693A5
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JP2009545043A
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JP5571387B2 (ja
JP2010515693A (ja
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Priority claimed from PCT/CA2008/000045 external-priority patent/WO2008083491A1/en
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Publication of JP2010515693A5 publication Critical patent/JP2010515693A5/ja
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JP2009545043A 2007-01-11 2008-01-11 癌の治療のための化合物および方法 Expired - Fee Related JP5571387B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US88448907P 2007-01-11 2007-01-11
US88450407P 2007-01-11 2007-01-11
US60/884,489 2007-01-11
US60/884,504 2007-01-11
PCT/CA2008/000045 WO2008083491A1 (en) 2007-01-11 2008-01-11 Compounds and method for treatment of cancer

Publications (3)

Publication Number Publication Date
JP2010515693A JP2010515693A (ja) 2010-05-13
JP2010515693A5 true JP2010515693A5 (enExample) 2011-03-03
JP5571387B2 JP5571387B2 (ja) 2014-08-13

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JP2009545043A Expired - Fee Related JP5571387B2 (ja) 2007-01-11 2008-01-11 癌の治療のための化合物および方法

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US (4) US8034815B2 (enExample)
EP (1) EP2121681B1 (enExample)
JP (1) JP5571387B2 (enExample)
CA (1) CA2673683C (enExample)
IL (1) IL199689A0 (enExample)
WO (1) WO2008083491A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2121681B1 (en) * 2007-01-11 2015-04-15 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
EP2225226B1 (en) 2007-12-26 2016-08-17 Critical Outcome Technologies, Inc. Compounds and their use in a method for treatment of cancer
EP3023426A1 (en) * 2008-07-17 2016-05-25 Critical Outcome Technologies, Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
CN102781237A (zh) * 2009-11-23 2012-11-14 天蓝制药公司 用于传递治疗剂的基于环糊精的聚合物
US8987272B2 (en) 2010-04-01 2015-03-24 Critical Outcome Technologies Inc. Compounds and method for treatment of HIV
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
US20140271812A1 (en) * 2013-03-14 2014-09-18 Panacea Pharmaceuticals Treatment for chemotherapy-induced cognitive impairment
US10392397B2 (en) 2015-08-06 2019-08-27 Nantbio, Inc. Heterocyclic thiosemicarbazone derivatives and their therapeutical applications
US11208478B2 (en) 2016-08-07 2021-12-28 The Wistar Institute Of Anatomy And Biology Methods of detecting and treating a tumor expressing pT346 PDK1

Family Cites Families (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3239539A (en) 1960-12-02 1966-03-08 Exxon Research Engineering Co Gem dimethylol alicyclic esters
GB1026401A (en) * 1961-02-23 1966-04-20 Wellcome Found Isatin thiosemicarbazones,their preparation and pharmaceutical formulations containing them
US3250791A (en) 1961-12-29 1966-05-10 Du Pont Tetracyanoethylene oxide and process for preparing same
GB1231783A (en) 1967-05-16 1971-05-12 May & Baker Ltd Benzene derivatives
DE1767924A1 (de) 1968-07-02 1971-10-07 Bayer Ag 1-Phenyl-4,4-dialkyl-thiosemicarbazide
JPS5695161A (en) * 1979-12-28 1981-08-01 Otsuka Pharmaceut Factory Inc 2-admantanon derivative
EP0096989A3 (en) 1982-05-26 1984-11-14 Toray Industries, Inc. Electrophotographic photosensitive material
US4537844A (en) 1982-10-08 1985-08-27 Ricoh Co. Ltd. Electrophotographic element containing disazo compound
CA1217491A (en) 1982-10-11 1987-02-03 Erhardt Winkelmann 3-aryl-7-chloro-3,4-dihydroacridine-1,9(2h,10h)-dione 1-oximes and 1-hydrazone derivatives, their salts, a process for their preparation, agents containing them and their use
DE3237649A1 (de) 1982-10-11 1984-04-12 Hoechst Ag, 6230 Frankfurt 3-aryl-7-chlor-10-hydroxy-3,4-dihydro-acridin-1,9-(2h, 10h)-dion-1-oxime und -1-hydrazonderivate, deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
HU189765B (en) 1983-10-25 1986-07-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing n-substituted 1-(bis (hydroxy-metiol)-methyl)-isoquinoline-derivatives
US4619878A (en) 1984-06-26 1986-10-28 Ricoh Co., Ltd. Tetrazonium salt compound, disazo compound, method for preparing the same, and photosensitive material containing said disazo compound for use in electrophotography
DE3569368D1 (en) 1984-11-30 1989-05-18 Fisons Plc Angiotensin converting enzyme inhibitors and their production and use as pharmaceuticals
DE3678805D1 (de) 1985-11-08 1991-05-23 Glaxo Group Ltd Indolderivate.
IL77496A (en) 1986-01-01 1989-02-28 Univ Ramot Anti-viral preparations comprising isatine 3-thiosemicarbazones
AU7285487A (en) 1986-04-07 1987-11-09 Upjohn Company, The Anthelmintic quaternaryalkyl acylhydrazones, method of use and compositions
US5023334A (en) 1986-10-03 1991-06-11 The Upjohn Company Anthelmintic pyridinyl acylhydrazones
DE3851598T2 (de) 1987-09-09 1995-05-24 Zeneca Ltd Schimmelbekämpfungsmittel.
US5155110A (en) 1987-10-27 1992-10-13 Warner-Lambert Company Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition
US4958010A (en) 1988-02-16 1990-09-18 Bristol-Myers Company Epipodophyllotoxin glucoside lactam derivatives
NZ229555A (en) 1988-06-16 1992-03-26 Rohm & Haas Pharmaceutical compositions for combating helminths in animals
JP2521137B2 (ja) 1988-11-08 1996-07-31 富士写真フイルム株式会社 電子写真感光体
US5196291A (en) 1989-05-24 1993-03-23 Fuji Photo Film Co., Ltd. Silver halide photographic material
DE69027725T2 (de) 1989-09-18 1997-03-06 Fuji Photo Film Co Ltd Photographisches Hochkontrast-Silberhalogenidmaterial
IL96127A0 (en) 1989-10-25 1991-07-18 Egyt Gyogyszervegyeszeti Gyar Triazole derivatives and process for their preparation
US5008265A (en) 1989-10-31 1991-04-16 Biocryst, Inc. 2-amino-7-(alicyclomethyl)-3H,5H,-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US4985433A (en) 1989-10-31 1991-01-15 Biocryst, Inc. 2-amino-7-(pyridinylmethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US5008270A (en) 1989-10-31 1991-04-16 Biocryst, Inc. 2-amino-7-(heterocyclomethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US4985434A (en) 1989-10-31 1991-01-15 Biocryst, Inc. 7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimidin-4-ones and pharamceutical uses and compositions containing the same
JP3093767B2 (ja) 1989-11-27 2000-10-03 松下電工株式会社 洗浄装置
US5189039A (en) 1989-11-29 1993-02-23 Biocryst, Inc. 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo[3,2d]pyrimidine and pharmaceutical uses and compositions containing the same
US5230983A (en) 1990-04-13 1993-07-27 Fuji Photo Film Co., Ltd. Silver halide photographic material
LU87766A1 (fr) 1990-07-20 1992-03-11 Oreal Utilisation de derives de pyrimidine 3-oxyde pour freiner la chute des cheveux et compositions topiques mises en oeuvre
NZ239846A (en) 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
US5747469A (en) 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
JPH05333467A (ja) 1991-05-02 1993-12-17 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US5714493A (en) 1991-05-10 1998-02-03 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5480883A (en) 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
USRE37650E1 (en) 1991-05-10 2002-04-09 Aventis Pharmacetical Products, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5710158A (en) 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
AU658646B2 (en) 1991-05-10 1995-04-27 Rhone-Poulenc Rorer International (Holdings) Inc. Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5344836A (en) 1991-11-11 1994-09-06 Ono Pharmaceutical Co., Ltd. Fused benzeneoxyacetic acid derivatives
DE4138820A1 (de) 1991-11-26 1993-05-27 Basf Ag Chinolin-3-carbonsaeureamide, deren herstellung und verwendung
JP2787630B2 (ja) 1992-02-06 1998-08-20 富士写真フイルム株式会社 ハロゲン化銀感光材料
DE4207400A1 (de) 1992-03-09 1993-09-16 Bayer Ag Hydrazone
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
US5358946A (en) 1992-05-29 1994-10-25 The Du Pont Merck Pharmaceutical Company Heterocycle-substituted amides, carbamates and ureas as agents for the treatment of atherosclerosis
JP2994182B2 (ja) 1992-07-23 1999-12-27 石原産業株式会社 アミド系化合物又はその塩、それらの製造方法及びそれらを含有する有害動物防除剤
EP0600832A1 (de) 1992-11-27 1994-06-08 Ciba-Geigy Ag Diaminobenzoe- und Diaminophthalsäurederivate und ihre Verfahren als Proteinkinase-Inhibitoren
TW251302B (enExample) 1992-12-28 1995-07-11 Kao Corp
US5618829A (en) 1993-01-28 1997-04-08 Mitsubishi Chemical Corporation Tyrosine kinase inhibitors and benzoylacrylamide derivatives
US5750088A (en) 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
JP3350739B2 (ja) 1993-06-10 2002-11-25 コニカ株式会社 黒白ハロゲン化銀写真感光材料の現像処理方法
US5543520A (en) 1993-10-01 1996-08-06 Ciba-Geigy Corporation Pyrimidine derivatives
EP0672035A1 (en) 1993-10-01 1995-09-20 Novartis AG Pyrimidineamine derivatives and processes for the preparation thereof
US5656643A (en) 1993-11-08 1997-08-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
AU686843B2 (en) 1994-02-23 1998-02-12 Pfizer Inc. 4-heterocyclyl-substituted quinazoline derivatives, processes for their preparation and their use as anti-cancer agents
DK0754672T3 (da) 1994-04-06 2000-11-13 Shionogi & Co Gamma-Substitueret phenyleddikesyrederivat, fremgangsmåde til fremstilling deraf og landbrugsfungicid indeholdende samme
EP0704215A3 (en) 1994-06-02 1998-04-01 Takeda Chemical Industries, Ltd. Inhibitor of vascular permeability enhancer
TW280906B (enExample) 1994-12-01 1996-07-11 Ibm
DE19501481A1 (de) 1995-01-19 1996-07-25 Bayer Ag 2,8-Disubstituierte Chinazolinone
JPH08220666A (ja) 1995-02-15 1996-08-30 Konica Corp 黒白ハロゲン化銀写真感光材料及びその処理方法
EP0824525B1 (en) 1995-04-27 2001-06-13 AstraZeneca AB Quinazoline derivatives
US5763470A (en) 1995-06-07 1998-06-09 Sugen Inc. Benzopyran compounds and methods for their use
US6265427B1 (en) 1995-06-07 2001-07-24 The Proctor & Gamble Company Pharmaceutical composition for the method of treating leukemia
EP0832073B1 (en) 1995-06-07 2002-01-16 Sugen, Inc. Quinazolines and pharmaceutical compositions
US5633786A (en) 1995-08-21 1997-05-27 Motorola Shield assembly and method of shielding suitable for use in a communication device
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
DE19545878A1 (de) 1995-12-08 1997-06-12 Basf Ag Pyridylcarbamate, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung
US5760041A (en) 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
DE19619518A1 (de) 1996-05-15 1997-11-20 Haeussler & Sauter Kg Verfahren zur Anbringung eines Fadens an einem Aufgußbeutel
DE69703221T2 (de) 1996-05-17 2001-02-15 Fuji Photo Film Co., Ltd. Photothermographisches Material
US20040171032A1 (en) 1996-06-06 2004-09-02 Baker Brenda F. Non-phosphorous-linked oligomeric compounds and their use in gene modulation
JP4386967B2 (ja) 1996-07-13 2009-12-16 グラクソ、グループ、リミテッド プロテインチロシンキナーゼ阻害剤としての縮合複素環式化合物
ES2191187T3 (es) 1996-07-13 2003-09-01 Glaxo Group Ltd Compuestos heteroaromaticos biciclicos como inhibidores de la proteina tirosin-quinasa.
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
DE69738468T2 (de) 1996-08-23 2009-01-08 Novartis Ag Substituierte pyrrolopyrimidine und verfahren zu ihrer herstellung
WO1998014450A1 (en) 1996-10-02 1998-04-09 Novartis Ag Pyrimidine derivatives and processes for the preparation thereof
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
ZA986729B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
ZA986732B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
EP0902028A1 (en) 1997-09-11 1999-03-17 E.I. Du Pont De Nemours And Company Tetrazoline herbicides
DE69839735D1 (de) 1997-12-15 2008-08-28 Astellas Pharma Inc Pyrimidin-5-carboxamid-derivate
US6184377B1 (en) 1997-12-15 2001-02-06 Sepracor Inc. Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof
DE69918950T2 (de) 1998-02-06 2005-07-28 De Montfort University Durch hydroxylierung aktivierte medikamentvorstufen
CA2330458A1 (en) 1998-04-29 1999-11-04 Georgetown University Methods of identifying and using hla binding compounds as hla-agonists and antagonists
US20010051628A1 (en) 1998-05-04 2001-12-13 H.-J. Su Huang Methods to modulate the resistance of cells to apoptosis mediated by mutant epidermal growth factor receptors
US6289352B1 (en) 1998-05-29 2001-09-11 Crystal Decisions, Inc. Apparatus and method for compound on-line analytical processing in databases
JPH11345811A (ja) 1998-06-01 1999-12-14 Seiko Instruments Inc 半導体装置の製造方法
US20030181495A1 (en) 1998-06-23 2003-09-25 Medinox, Inc. Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor
US6596770B2 (en) 2000-05-05 2003-07-22 Medinox, Inc. Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor
JP2002523455A (ja) 1998-08-31 2002-07-30 スージェン・インコーポレーテッド 蛋白質キナーゼ活性の調節剤としての幾何学的に制限された２−インドリノン誘導体
JP2000143636A (ja) 1998-09-02 2000-05-26 Sumitomo Pharmaceut Co Ltd アミノ誘導体
US20020010550A1 (en) 1998-09-14 2002-01-24 George M. Grass Pharmacokinetic-based drug design tool and method
US6420560B1 (en) 1999-06-07 2002-07-16 Theravance, Inc. H1—histamine receptor antagonists
US6538002B1 (en) 1999-06-11 2003-03-25 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
EA005287B1 (ru) 1999-09-15 2004-12-30 Уорнер-Ламберт Компани Птеридиноны в качестве ингибиторов киназ
US7264932B2 (en) 1999-09-24 2007-09-04 Applera Corporation Nuclease inhibitor cocktail
GB9924862D0 (en) 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
JP2001172217A (ja) 1999-12-21 2001-06-26 Shionogi & Co Ltd 殺ダニ活性および殺菌活性を有するエチレン誘導体
GB2357971A (en) 1999-12-23 2001-07-11 Novartis Ag Protection of plants against microorganism attack
ITMI992711A1 (it) 1999-12-27 2001-06-27 Novartis Ag Composti organici
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
EP1200422A2 (en) 2000-02-05 2002-05-02 Vertex Pharmaceuticals Incorporated Pyrazole compositions useful as inhibitors of erk
US6313138B1 (en) 2000-02-25 2001-11-06 Merck & Co., Inc. Tyrosine kinase inhibitors
US6420382B2 (en) 2000-02-25 2002-07-16 Merck & Co., Inc. Tyrosine kinase inhibitors
AU2001243372A1 (en) 2000-03-01 2001-09-12 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
GB0007657D0 (en) 2000-03-29 2000-05-17 Celltech Therapeutics Ltd Chemical compounds
GB2372562A (en) 2000-04-26 2002-08-28 Ribotargets Ltd In silico screening
EP1152010B1 (en) 2000-05-05 2010-04-21 Wallac Oy Oligonucleotide labeling reactants and their use
DE10023492A1 (de) 2000-05-09 2001-11-22 Schering Ag Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel
US6489094B2 (en) 2000-05-31 2002-12-03 Pfizer Inc. Method and device for drug-drug interaction testing sample preparation
US7211192B2 (en) 2000-06-02 2007-05-01 The Regents Of The University Of California Hybrid organic-inorganic adsorbents
US7022484B2 (en) 2000-06-08 2006-04-04 Board Of Regents, The University Of Texas System Methods for treating neuropathological states and neurogenic inflammatory states and methods for identifying compounds useful therein
US20020028826A1 (en) 2000-06-15 2002-03-07 Robl Jeffrey A. HMG-CoA reductase inhibitors and method
US20020013334A1 (en) 2000-06-15 2002-01-31 Robl Jeffrey A. HMG-CoA reductase inhibitors and method
US6620821B2 (en) 2000-06-15 2003-09-16 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
BR0112355A (pt) 2000-06-26 2005-04-19 Univ Michigan Uso de inibidores da proteìna egf-r tirosina cinase para a prevenção do fotoenvelhecimento da pele humana
EP1311277A4 (en) 2000-07-18 2004-08-25 Joslin Diabetes Center Inc METHODS OF FIBROSIS MODULATION
US7067046B2 (en) 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
US6647342B2 (en) 2000-08-07 2003-11-11 Novodynamics, Inc. Knowledge-based process for the development of materials
GB0022438D0 (en) 2000-09-13 2000-11-01 Novartis Ag Organic Compounds
WO2002032861A2 (en) 2000-10-17 2002-04-25 Merck & Co., Inc. Orally active salts with tyrosine kinase activity
JP4366081B2 (ja) 2001-05-22 2009-11-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 高度に精製されたアンチエンドトキシン化合物
JP2002361158A (ja) 2001-06-07 2002-12-17 Aica Kogyo Co Ltd 塗布装置
US6352168B1 (en) 2001-06-21 2002-03-05 Jung-Chuang Lin Rotation cup
WO2003004489A1 (en) 2001-07-05 2003-01-16 Gpc Biotech Inc. Compositions and methods for inhibiting prenyltransferases
AU2002333233A1 (en) 2001-07-09 2003-01-29 Pharmacia Italia Spa Interaction inhibitors of tcf-4 with beta-catenin
WO2003070241A1 (en) * 2002-02-15 2003-08-28 Rigel Pharmaceuticals, Inc. Inhibitors of tubulin polymerization
FR2840303B1 (fr) 2002-05-31 2005-07-15 Rhodia Chimie Sa Procede d'arylation ou de vinylation ou d'alcylynation d'un compose nucleophile
CA2481995A1 (en) 2002-04-08 2003-10-16 Torrent Pharmaceuticals Ltd. Thiazolidine-4-carbonitriles and analogues and their use as dipeptidyl-peptidas inhibitors
WO2004037787A1 (de) 2002-10-18 2004-05-06 Basf Aktiengesellschaft 1-phenylpyrrolidin-2-on-3-carboxamide
DE602004031095D1 (de) 2003-02-05 2011-03-03 David Benn Lovejoy Metallionenchelatoren und ihre therapeutische verwendung
CA2515515A1 (en) 2003-02-18 2004-09-02 Whitehead Institute For Biomedical Research Mtor kinase-associated proteins
EP1614676A4 (en) 2003-03-27 2009-03-25 Kirin Pharma Kk CONNECTION TO INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICAMENT CONTAINING THEREOF
US20040193538A1 (en) 2003-03-31 2004-09-30 Raines Walter L. Receipt processing system and method
US7427683B2 (en) 2003-04-25 2008-09-23 Ortho-Mcneil Pharmaceutical, Inc. c-fms kinase inhibitors
US20050010017A1 (en) 2003-07-11 2005-01-13 Blakely Dale Milton Addition of UV inhibitors to pet process for maximum yield
WO2005039489A2 (en) 2003-09-24 2005-05-06 Polymerix Corporation Compositions and methods for the inhibition of bone growth and resorption
JP2007518799A (ja) 2004-01-20 2007-07-12 メルク　エンド　カムパニー　インコーポレーテッド ケモカイン受容体活性モジュレーターとしての２，６−二置換ピペリジン
BRPI0506948B1 (pt) 2004-01-30 2018-09-18 Medivir Ab inibidores de serina protease ns-3 de hcv
US20070197495A1 (en) 2004-03-05 2007-08-23 The Regents Of The University Of California Anti-parasitic compounds and methods of their use
DE502005002697D1 (de) 2004-10-13 2008-03-13 Merck Patent Gmbh Als kinaseinhibitoren geeignete derivate des n,n'-diphenylharnstoffs
FR2879194B1 (fr) 2004-12-14 2007-01-19 Galderma Res & Dev Nouveaux composes bi-aromatiques modulateurs des recepteurs de type ppar, leur procede de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
AR054416A1 (es) 2004-12-22 2007-06-27 Incyte Corp Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas.
JP2006181940A (ja) 2004-12-28 2006-07-13 Mitsubishi Paper Mills Ltd インクジェット用記録材料
CN1891701A (zh) 2005-07-07 2007-01-10 桑迪亚医药技术（上海）有限责任公司 杂芳环缩氨基硫脲类化合物及其衍生物和它们在制备抗肿瘤药物中的应用
CN100497309C (zh) 2005-08-04 2009-06-10 卡南吉医药科技（上海）有限公司 杂芳环缩氨基硫脲类抗肿瘤药物的合成方法
AU2006295260A1 (en) 2005-08-29 2007-04-05 Gerard M. Housey Theramutein modulators
WO2007106503A2 (en) 2006-03-13 2007-09-20 Osi Pharmaceuticals, Inc. Combined treatment with an egfr kinase inhibitor and an agent that sensitizes tumor cells to the effects of egfr kinase inhibitors
JP2008008853A (ja) 2006-06-30 2008-01-17 Univ Of Electro-Communications 地点間距離変動検出装置及び方法
JP2008088107A (ja) 2006-10-02 2008-04-17 Fujiyakuhin Co Ltd 新規ピリダジン誘導体
EP2121681B1 (en) 2007-01-11 2015-04-15 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
EP2225226B1 (en) 2007-12-26 2016-08-17 Critical Outcome Technologies, Inc. Compounds and their use in a method for treatment of cancer
EP3023426A1 (en) * 2008-07-17 2016-05-25 Critical Outcome Technologies, Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods

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