ATE495794T1 - Metallionenchelatoren und ihre therapeutische verwendung - Google Patents
Metallionenchelatoren und ihre therapeutische verwendungInfo
- Publication number
- ATE495794T1 ATE495794T1 AT04708284T AT04708284T ATE495794T1 AT E495794 T1 ATE495794 T1 AT E495794T1 AT 04708284 T AT04708284 T AT 04708284T AT 04708284 T AT04708284 T AT 04708284T AT E495794 T1 ATE495794 T1 AT E495794T1
- Authority
- AT
- Austria
- Prior art keywords
- therapeutic use
- metal ion
- compounds
- ion chelators
- thio
- Prior art date
Links
- 229910021645 metal ion Inorganic materials 0.000 title abstract 4
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 239000002738 chelating agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- -1 iron ions Chemical class 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
- SGAUPIBMJQWCEK-UHFFFAOYSA-N thionitrosourea Chemical class NC(=O)NN=S SGAUPIBMJQWCEK-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003900495A AU2003900495A0 (en) | 2003-02-05 | 2003-02-05 | Aroylhydrazone derivatives and therapeutic uses thereof |
| AU2003900922A AU2003900922A0 (en) | 2003-02-11 | 2003-02-11 | (Thio) semicarbazone and (thio) hydrazone compounds and therapeutic uses thereof |
| PCT/AU2004/000132 WO2004069801A1 (en) | 2003-02-05 | 2004-02-05 | Metal ion chelators and therapeutic use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE495794T1 true ATE495794T1 (de) | 2011-02-15 |
Family
ID=32851548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04708284T ATE495794T1 (de) | 2003-02-05 | 2004-02-05 | Metallionenchelatoren und ihre therapeutische verwendung |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20060252798A1 (de) |
| EP (1) | EP1608623B1 (de) |
| JP (1) | JP2006516979A (de) |
| AT (1) | ATE495794T1 (de) |
| CA (1) | CA2515027A1 (de) |
| DE (1) | DE602004031095D1 (de) |
| WO (1) | WO2004069801A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2121681B1 (de) | 2007-01-11 | 2015-04-15 | Critical Outcome Technologies, Inc. | Verbindungen und verfahren zur behandlung von krebs |
| EP2155643B1 (de) * | 2007-06-08 | 2016-08-10 | MannKind Corporation | Ire-1a-inhibitoren |
| EP2225226B1 (de) * | 2007-12-26 | 2016-08-17 | Critical Outcome Technologies, Inc. | Verbindungen und ihre verwending in einem verfahren zur behandlung von krebs |
| WO2010000008A1 (en) * | 2008-06-30 | 2010-01-07 | Desi Raymond Richardson | Thiosemicarbazone compounds and use thereof |
| CA2999321A1 (en) | 2008-07-17 | 2010-01-21 | Critical Outcome Technologies Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
| WO2010147621A1 (en) * | 2009-06-16 | 2010-12-23 | The Trustees Of Columbia University In The City Of New York | Methods for ameliorating adverse effects associated with transfusion of aged red blood cells |
| EP2552915B1 (de) | 2010-04-01 | 2017-07-19 | Critical Outcome Technologies Inc. | Verbindungen zur behandlung von hiv |
| AU2011342378B2 (en) * | 2010-12-17 | 2016-09-01 | David B. Lovejoy | Thiosemicarbazone compounds and use in the treatment of cancer |
| EP2688569B1 (de) * | 2011-03-21 | 2018-05-30 | Vivolux Ab | Behandlung fester tumore |
| EP2945629A4 (de) * | 2012-11-22 | 2016-09-28 | Oncochel Therapeutics LLC | Chemotherapie für therapieresistente krebszellen |
| US11504346B2 (en) | 2013-11-03 | 2022-11-22 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Redox-activated pro-chelators |
| MD4407C1 (ro) * | 2015-04-29 | 2016-10-31 | Государственный Университет Молд0 | Inhibitor al celulelor HL-60 ale leucemiei umane mieloide în baza hidratului clorurii de bis[N-(prop-2-en-1-il)-2-(piridin-2-ilmetiliden)-hidrazincarbotioamid]-nichel(II) |
| DE102015225880A1 (de) * | 2015-12-18 | 2017-06-22 | Henkel Ag & Co. Kgaa | Pyridingruppenhaltige Acylhydrazone |
| CN106311182A (zh) * | 2016-10-18 | 2017-01-11 | 江苏理工学院 | 一种超细螯合纤维的制备方法及其应用 |
| CN113024449B (zh) * | 2021-03-18 | 2023-11-28 | 中国科学技术大学 | 一种含金属的高效阳离子抗肿瘤药物及其制备方法和应用 |
| WO2024044271A2 (en) * | 2022-08-24 | 2024-02-29 | University Of Puerto Rico | Metal chelator compounds, coordination complexes, and methods of preparation and use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4207400A1 (de) * | 1992-03-09 | 1993-09-16 | Bayer Ag | Hydrazone |
| DE4207401A1 (de) * | 1992-03-09 | 1993-09-16 | Bayer Ag | Mikrobizide hydrazone |
| DE4217723A1 (de) * | 1992-05-29 | 1993-12-02 | Bayer Ag | Thiosemicarbazide |
| JPH11209352A (ja) * | 1998-01-21 | 1999-08-03 | Nippon Bayer Agrochem Co Ltd | チオセミカルバゾン類および有害生物防除剤 |
-
2004
- 2004-02-05 CA CA002515027A patent/CA2515027A1/en not_active Abandoned
- 2004-02-05 JP JP2006501349A patent/JP2006516979A/ja active Pending
- 2004-02-05 EP EP04708284A patent/EP1608623B1/de not_active Expired - Lifetime
- 2004-02-05 AT AT04708284T patent/ATE495794T1/de not_active IP Right Cessation
- 2004-02-05 DE DE602004031095T patent/DE602004031095D1/de not_active Expired - Lifetime
- 2004-02-05 WO PCT/AU2004/000132 patent/WO2004069801A1/en active Application Filing
- 2004-02-05 US US10/544,570 patent/US20060252798A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2515027A1 (en) | 2004-08-19 |
| EP1608623A1 (de) | 2005-12-28 |
| EP1608623B1 (de) | 2011-01-19 |
| JP2006516979A (ja) | 2006-07-13 |
| DE602004031095D1 (de) | 2011-03-03 |
| US20060252798A1 (en) | 2006-11-09 |
| WO2004069801A1 (en) | 2004-08-19 |
| EP1608623A4 (de) | 2007-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |