JP2010514677A5 - - Google Patents

Download PDF

Info

Publication number
JP2010514677A5
JP2010514677A5 JP2009543119A JP2009543119A JP2010514677A5 JP 2010514677 A5 JP2010514677 A5 JP 2010514677A5 JP 2009543119 A JP2009543119 A JP 2009543119A JP 2009543119 A JP2009543119 A JP 2009543119A JP 2010514677 A5 JP2010514677 A5 JP 2010514677A5
Authority
JP
Japan
Prior art keywords
alkyl
hetero
propanamide
oxopyridin
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009543119A
Other languages
English (en)
Japanese (ja)
Other versions
JP5419706B2 (ja
JP2010514677A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/087807 external-priority patent/WO2008079787A2/en
Publication of JP2010514677A publication Critical patent/JP2010514677A/ja
Publication of JP2010514677A5 publication Critical patent/JP2010514677A5/ja
Application granted granted Critical
Publication of JP5419706B2 publication Critical patent/JP5419706B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009543119A 2006-12-20 2007-12-17 グルコキナーゼアクチベーター Expired - Fee Related JP5419706B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87092906P 2006-12-20 2006-12-20
US60/870,929 2006-12-20
PCT/US2007/087807 WO2008079787A2 (en) 2006-12-20 2007-12-17 Glucokinase activators

Publications (3)

Publication Number Publication Date
JP2010514677A JP2010514677A (ja) 2010-05-06
JP2010514677A5 true JP2010514677A5 (cg-RX-API-DMAC7.html) 2011-02-10
JP5419706B2 JP5419706B2 (ja) 2014-02-19

Family

ID=39446103

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009543119A Expired - Fee Related JP5419706B2 (ja) 2006-12-20 2007-12-17 グルコキナーゼアクチベーター

Country Status (4)

Country Link
US (2) US8163779B2 (cg-RX-API-DMAC7.html)
EP (1) EP2091947A2 (cg-RX-API-DMAC7.html)
JP (1) JP5419706B2 (cg-RX-API-DMAC7.html)
WO (1) WO2008079787A2 (cg-RX-API-DMAC7.html)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7842713B2 (en) 2006-04-20 2010-11-30 Pfizer Inc Fused phenyl amido heterocyclic compounds
US8314087B2 (en) * 2007-02-16 2012-11-20 Amgen Inc. Nitrogen-containing heterocyclyl ketones and methods of use
EA018988B1 (ru) 2008-05-16 2013-12-30 Такеда Калифорния, Инк. Активаторы глюкокиназы
EP2296653B1 (en) 2008-06-03 2016-01-27 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US20110130365A1 (en) * 2008-07-29 2011-06-02 Benbow John W Fluorinated Heteroaryls
KR101258331B1 (ko) 2008-09-11 2013-04-26 화이자 인코포레이티드 헤테로아릴 아미드 유도체 및 글루코키나제 활성화제로서의 그의 용도
JP2012515760A (ja) * 2009-01-20 2012-07-12 ファイザー・インク 置換ピラジノンアミド
AU2010222589B2 (en) 2009-03-11 2012-08-16 Pfizer Inc. Benzofuranyl derivatives used as glucokinase inhibitors
US20110021570A1 (en) * 2009-07-23 2011-01-27 Nancy-Ellen Haynes Pyridone glucokinase activators
MX2012005994A (es) 2009-12-04 2012-08-08 Taisho Pharmaceutical Co Ltd Compuestos de 2-piridona.
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
ES2893699T3 (es) 2010-03-31 2022-02-09 Scripps Research Inst Reprogramación de células
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
HK1202458A1 (en) 2012-05-17 2015-10-02 Vtv治疗有限责任公司 Glucokinase activator compositions for the treatment of diabetes
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
WO2014077235A1 (ja) 2012-11-13 2014-05-22 大正製薬株式会社 2-ピリドン化合物
EP2964198A2 (en) * 2013-03-04 2016-01-13 vTv Therapeutics LLC Stable glucokinase activator compositions
EP2978425B1 (en) 2013-03-27 2017-09-27 Merck Sharp & Dohme Corp. Factor xia inhibitors
TWI633089B (zh) * 2013-03-28 2018-08-21 拜耳製藥股份有限公司 經取代的酮基吡啶衍生物
JP6410819B2 (ja) 2013-07-23 2018-10-24 バイエル ファーマ アクチエンゲゼルシャフト 置換オキソピリジン誘導体および第XIa因子/血漿としてのその使用
WO2015063093A1 (de) 2013-10-30 2015-05-07 Bayer Pharma Aktiengesellschaft Substituierte oxopyridin-derivate
EP3138839B1 (en) * 2014-02-14 2020-10-28 Sichuan Haisco Pharmaceutical Co., Ltd. Pyridone or pyrimidone derivative, preparation method therefor and application thereof
CN110452216B (zh) 2014-04-02 2022-08-26 英特穆恩公司 抗纤维化吡啶酮类
WO2016011940A1 (zh) * 2014-07-25 2016-01-28 江苏恒瑞医药股份有限公司 氮茚-酰胺类衍生物、其制备方法及其在医药上的应用
WO2016046166A1 (de) 2014-09-24 2016-03-31 Bayer Pharma Aktiengesellschaft Substituierte oxopyridin-derivate
ES2722423T3 (es) * 2014-09-24 2019-08-12 Bayer Pharma AG Derivados de oxopiridina sustituidos
EP3197891B1 (de) 2014-09-24 2018-11-21 Bayer Pharma Aktiengesellschaft Faktor xia hemmende pyridobenzazepin- und pyridobenzazocin-derivate
WO2016046164A1 (de) * 2014-09-24 2016-03-31 Bayer Pharma Aktiengesellschaft Substituierte oxopyridin-derivate
EP3197880B1 (de) 2014-09-24 2018-10-24 Bayer Pharma Aktiengesellschaft Substituierte oxopyridin-derivate mit anti-inflammatorischer und anti-thrombotischer wirkung
US10071995B2 (en) 2014-09-24 2018-09-11 Bayer Pharma Aktiengesellschaft Substituted oxopyridine derivatives
PL3263133T3 (pl) 2015-02-27 2020-10-05 Kyushu University, National University Corporation Związek pirydynonu i jego zastosowanie
WO2017003723A1 (en) 2015-07-01 2017-01-05 Crinetics Pharmaceuticals, Inc. Somatostatin modulators and uses thereof
JO3703B1 (ar) 2015-07-09 2021-01-31 Bayer Pharma AG مشتقات أوكسوبيريدين مستبدلة
US20180250280A1 (en) 2015-09-04 2018-09-06 Bayer Pharma Aktiengesellschaft Substituted oxopyridine derivatives
WO2019023278A1 (en) 2017-07-25 2019-01-31 Crinetics Pharmaceuticals, Inc. MODULATORS OF SOMATOSTATIN AND USES THEREOF
GB201714777D0 (en) 2017-09-14 2017-11-01 Univ London Queen Mary Agent
UY37907A (es) 2017-09-29 2019-04-30 Bayer Ag 3-fenilquinazolin-4 (3h)-onas sustituidas y sus usos
WO2019063708A1 (en) 2017-09-29 2019-04-04 Bayer Aktiengesellschaft SUBSTITUTED 3-PHENYLQUINAZOLIN-4 (3H) -ONES AND USES THEREOF
ES2922533T3 (es) 2018-04-10 2022-09-16 Bayer Pharma AG Un derivado de oxopiridina sustituido
MX2020008905A (es) 2018-06-12 2020-12-03 Vtv Therapeutics Llc Usos terapeuticos de activadores de glucoquinasa en combinacion con insulina o analogos de insulinas.
AR117435A1 (es) 2018-12-21 2021-08-04 Bayer Ag Derivados de oxopiridina sustituidos
EP3898634A1 (en) 2018-12-21 2021-10-27 Bayer Aktiengesellschaft Substituted oxopyridine derivatives
CN115066240A (zh) 2019-11-11 2022-09-16 达纳-法伯癌症研究所股份有限公司 变构egfr抑制剂及其使用方法
US12391658B2 (en) 2020-02-18 2025-08-19 Vtv Therapeutics Llc Sulfoxide and sulfone glucokinase activators and methods of use thereof
WO2021252311A1 (en) 2020-06-08 2021-12-16 Vtv Therapeutics Llc Salts or co-crystals of {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid and uses thereof
WO2021252661A1 (en) * 2020-06-09 2021-12-16 Dana-Farber Cancer Institute, Inc. Allosteric egfr inhibitors and methods of use thereof

Family Cites Families (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB921315A (en) 1958-03-31 1963-03-20 Wellcome Found The manufacture of 8-aminoalkylamino quinoline derivatives
US3956287A (en) 1973-11-07 1976-05-11 Richardson-Merrell Inc. 7-[(2-Oxo-1-pyridinyl)acylamino]cephalosporin derivatives
JPS62232555A (ja) 1986-04-02 1987-10-13 Unitika Ltd 酵素センサ
US4959212A (en) 1988-06-22 1990-09-25 Alexandra Stancesco Oxidizing-energizing composition and method for the treatment of diabetes
US5239080A (en) 1989-02-08 1993-08-24 Takeda Chemical Industries, Ltd. Oxazole compounds and their use as antidiabetic and bone-reduction inhibitory agents
DE4211474A1 (de) * 1992-04-06 1993-10-07 Merck Patent Gmbh Imidazopyridine
US5541060A (en) 1992-04-22 1996-07-30 Arch Development Corporation Detection of glucokinase-linked early-onset non-insulin-dependent diabetes mellitus
DE69419639T2 (de) 1993-03-17 1999-12-16 Unitika Ltd., Amagasaki Verfahren zur Herstellung von Fructose-2,6-diphosphat und Reinigungsverfahren hierfür
JP3203108B2 (ja) 1993-08-26 2001-08-27 協和メデックス株式会社 グルコース−6−リン酸デヒドロゲナーゼの安定化方法
DE4341665A1 (de) 1993-12-07 1995-06-08 Basf Ag Bicyclen-Derivate, ihre Herstellung und Verwendung
US6486380B1 (en) 1993-12-17 2002-11-26 University Of North Dakota Medical Education Research Foundation Pancreatic β cell hexokinase transgene
US7041503B2 (en) 1995-05-02 2006-05-09 The United States Of America As Represented By The Department Of Health And Human Services Modified myelin basic protein molecules
US5854067A (en) 1996-01-19 1998-12-29 Board Of Regents, The University Of Texas System Hexokinase inhibitors
GB9618934D0 (en) 1996-09-11 1996-10-23 Univ London Inositol phosphoglycans for therapeutic use in the treatment of diabetes and obesity
US6642360B2 (en) 1997-12-03 2003-11-04 Genentech, Inc. Secreted polypeptides that stimulate release of proteoglycans from cartilage
US20020032330A1 (en) 1996-12-24 2002-03-14 Yutaka Nomura Propionic acid derivatives
FR2758326B1 (fr) * 1997-01-16 1999-02-12 Synthelabo Derives de pyridone, leur prepaparation et leur utilisation comme intermediaires de synthese
US20020137890A1 (en) 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7378507B2 (en) 1997-09-18 2008-05-27 Genentech, Inc. PRO217 polypeptides
ZA988460B (en) 1997-09-17 1999-03-19 Genentech Inc Polypeptides and nucleic acids encoding the same
US6391311B1 (en) 1998-03-17 2002-05-21 Genentech, Inc. Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
US6894148B2 (en) 1997-11-12 2005-05-17 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030129691A1 (en) 1998-02-09 2003-07-10 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20040048332A1 (en) 1998-04-29 2004-03-11 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030073188A1 (en) 1998-07-07 2003-04-17 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030166132A1 (en) 1998-08-26 2003-09-04 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6242666B1 (en) 1998-12-16 2001-06-05 The Scripps Research Institute Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells
US20030009013A1 (en) 1998-12-30 2003-01-09 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP2002540175A (ja) 1999-02-19 2002-11-26 ドウアリング,マシユー・ジエイ 糖尿病及び肥満症の経口遺伝子治療
KR20030002292A (ko) 1999-03-08 2003-01-08 제넨테크, 인크. 분비 및 막횡단 폴리펩티드 및 이를 코딩하는 핵산
PT1169312E (pt) 1999-03-29 2005-01-31 Hoffmann La Roche Activadores de glicocinase
US6320050B1 (en) 1999-03-29 2001-11-20 Hoffmann-La Roche Inc. Heteroaromatic glucokinase activators
US6610846B1 (en) 1999-03-29 2003-08-26 Hoffman-La Roche Inc. Heteroaromatic glucokinase activators
RU2242469C2 (ru) 1999-03-29 2004-12-20 Ф.Хоффманн-Ля Рош Аг Активаторы глюкокиназы
US6967019B2 (en) 1999-04-06 2005-11-22 The Regents Of The University Of California Production of pancreatic islet cells and delivery of insulin
US8193330B2 (en) 1999-04-06 2012-06-05 The Regents Of The University Of California Polynucleotides comprising Neurogenin3 promoter and bHLH encoding domains
US6774120B1 (en) 1999-06-01 2004-08-10 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
JP4447705B2 (ja) 1999-10-20 2010-04-07 独立行政法人科学技術振興機構 糖尿病発症モデル哺乳動物
US20040072739A1 (en) 1999-11-10 2004-04-15 Anderson Christen M. Compositions and methods for regulating endogenous inhibitor of ATP synthase, including treatment for diabetes
AR026748A1 (es) 1999-12-08 2003-02-26 Vertex Pharma Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis
US6353111B1 (en) 1999-12-15 2002-03-05 Hoffmann-La Roche Inc. Trans olefinic glucokinase activators
US6608038B2 (en) 2000-03-15 2003-08-19 Novartis Ag Methods and compositions for treatment of diabetes and related conditions via gene therapy
US6716582B2 (en) 2000-04-14 2004-04-06 E. I. Du Pont De Nemours And Company Cellular arrays for the identification of altered gene expression
AU2001295841A1 (en) 2000-04-25 2002-01-02 German Human Genome Project Human dna sequences
DK1280801T3 (da) * 2000-05-03 2006-01-23 Hoffmann La Roche Hydantoinholdige glucokinaseaktivatorer
PT1282612E (pt) 2000-05-03 2005-04-29 Hoffmann La Roche Actividades heteroaromaticas da glucoquinase a vase de alcinilo-fenilo
US6489485B2 (en) 2000-05-08 2002-12-03 Hoffmann-La Roche Inc. Para-amine substituted phenylamide glucokinase activators
KR100548901B1 (ko) 2000-05-08 2006-02-02 에프. 호프만-라 로슈 아게 치환된 페닐아세트아미드 및 그의 글루코키나제활성화제로서의 용도
AU6591401A (en) 2000-05-08 2001-11-20 Hoffmann La Roche Para-amine substituted phenylamide glucokinase activators
AU2001263006A1 (en) 2000-05-18 2001-11-26 Hyseq, Inc. Novel nucleic acids and polypeptides
AU2001263360A1 (en) 2000-05-19 2001-12-03 Millennium Pharmaceuticals, Inc. 50365, a hexokinase family member and uses thereof
WO2001092523A2 (en) 2000-05-30 2001-12-06 Curagen Corporation Human polynucleotides and polypeptides encoded thereby
CA2410823A1 (en) 2000-05-31 2001-12-06 Jolanta Vidugiriene Assay for kinases and phosphatases
WO2002000691A2 (en) 2000-06-27 2002-01-03 Curagen Corporation Polynucleotides and polypeptides encoded thereby
AU2002214531A1 (en) 2000-07-03 2002-01-30 Curagen Corporation Proteins and nucleic acids encoding same
AU2001269709A1 (en) 2000-07-19 2002-02-05 Eli Lilly And Company Nucleic acids, vectors, host cells, polypeptides, and uses thereof
WO2002008209A1 (en) 2000-07-20 2002-01-31 F. Hoffmann-La Roche Ag Alpha-acyl and alpha-heteroatom-substituted benzene acetamide glucokinase activators
EP1354040A2 (en) 2000-07-20 2003-10-22 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7371817B2 (en) 2000-07-25 2008-05-13 Genentech, Inc. PRO9783 polypeptides
US20030100709A1 (en) 2000-07-25 2003-05-29 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20040044179A1 (en) 2000-07-25 2004-03-04 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030212255A1 (en) 2000-07-26 2003-11-13 Muralidhara Padigaru Novel proteins and nucleic acids encoding same
AU2001280471A1 (en) 2000-08-11 2002-02-25 Eli Lilly And Company Novel secreted proteins and their uses
US6369232B1 (en) 2000-08-15 2002-04-09 Hoffmann-La Roche Inc. Tetrazolyl-phenyl acetamide glucokinase activators
EP1309679A2 (en) 2000-08-16 2003-05-14 Chiron Corporation Human genes and gene expression products
WO2002016578A2 (en) 2000-08-24 2002-02-28 Eli Lilly And Company Secreted proteins and methods of using same
WO2002016599A2 (en) 2000-08-25 2002-02-28 Curagen Corporation Proteins and nucleic acids encoding same
US6346416B1 (en) 2000-08-29 2002-02-12 Isis Pharmaceuticals, Inc. Antisense inhibition of HPK/GCK-like kinase expression
US6849728B1 (en) 2000-08-31 2005-02-01 Wake Forest University Health Sciences GLUT10: a glucose transporter in the type 2 diabetes linked region of chromosome 20Q12-13.1
CA2422068A1 (en) 2000-09-13 2002-03-21 Eleanor Roosevelt Institute Method for treatment of insulin resistance in obesity and diabetes
US20030187201A1 (en) 2000-09-15 2003-10-02 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU2001290551A1 (en) 2000-09-28 2002-04-08 Eli Lilly And Company Secreted proteins and their uses
WO2002032939A2 (en) 2000-10-19 2002-04-25 Eli Lilly And Company Secreted proteins and their uses
WO2002057450A2 (en) 2000-11-29 2002-07-25 Curagen Corporation Proteins and nucleic acids encoding same
US6433188B1 (en) 2000-12-06 2002-08-13 Wendy Lea Corbett Fused heteroaromatic glucokinase activators
DK1341774T3 (da) 2000-12-06 2006-06-12 Hoffmann La Roche Kondenserede heteroaromatiske glucokinase-aktivatorer
EP1366162A2 (en) 2000-12-06 2003-12-03 Curagen Corporation Putative proteins and nucleic acids encoding same
US20040033491A1 (en) 2000-12-08 2004-02-19 Alsobrook John P. Proteins and nucleic acids encoding same
US6482951B2 (en) 2000-12-13 2002-11-19 Hoffmann-La Roche Inc. Isoindolin-1-one glucokinase activators
EP1399474A2 (en) 2000-12-15 2004-03-24 Eli Lilly And Company Secreted proteins and their use
US20030235882A1 (en) 2000-12-19 2003-12-25 Shimkets Richard A. Novel nucleic acids and polypeptides and methods of use thereof
CA2433313A1 (en) 2000-12-19 2002-07-25 Curagen Corporation Polypetides and nucleic acids encoding same
ES2170720B1 (es) 2000-12-20 2003-12-16 Univ Barcelona Autonoma Utilizacion conjunta del gen de la insulina y del gen de la glucoquinasa en el desarrollo de aproximaciones terapeuticas para la diabetes mellitus.
WO2002050277A2 (en) 2000-12-21 2002-06-27 Curagen Corporation Protein and nucleic acids encoding same
US7241579B2 (en) 2000-12-22 2007-07-10 Smithkline Beecham Corporation Method of screening for GPR40 ligands
US7247705B2 (en) 2000-12-28 2007-07-24 Takeda Pharmaceutical Company Limited Proteins having glucose transporter activity
WO2002055704A2 (en) 2001-01-09 2002-07-18 Curagen Corp Proteins, polynucleotides encoding them and methods of using the same
JP2005508133A (ja) 2001-01-11 2005-03-31 キュラジェン コーポレイション タンパク質およびそれをコードする核酸
JP4146095B2 (ja) 2001-01-15 2008-09-03 ユニチカ株式会社 耐熱性グルコキナーゼ遺伝子、それを含有する組換えベクター、その組換えベクターを含有する形質転換体及びその形質転換体を用いた耐熱性グルコキナーゼの製造方法
US20040043457A1 (en) 2001-01-18 2004-03-04 Silke Schumacher Bifunctional fusion proteins with glucocerebrosidase activity
GB0101447D0 (en) 2001-01-19 2001-03-07 Univ Edinburgh Regulation of glucocorticoid concentration
WO2002081517A2 (en) 2001-01-19 2002-10-17 Curagen Corporation Novel polypeptides and nucleic acids encoded thereby
US20040081981A1 (en) 2001-01-31 2004-04-29 Toru Egashira Method of detecting risk factor for onset of diabetes
WO2002068649A2 (en) 2001-01-31 2002-09-06 Curagen Corporation Proteins and nucleic acids encoding same
US20040086875A1 (en) 2001-11-05 2004-05-06 Agee Michele L. Novel proteins and nucleic acids encoding same
US20040053245A1 (en) 2001-02-05 2004-03-18 Tang Y. Tom Novel nucleic acids and polypeptides
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6783969B1 (en) 2001-03-05 2004-08-31 Nuvelo, Inc. Cathepsin V-like polypeptides
WO2002072757A2 (en) 2001-03-08 2002-09-19 Curagen Corporation Novel proteins and nucleic acids encoding same
CN1496412B (zh) 2001-03-14 2012-08-08 香港中文大学 用于评估中国血统的人种发展2型糖尿病危险性的方法和组合物
JP4602577B2 (ja) 2001-03-15 2010-12-22 積水メディカル株式会社 前糖尿病状態のスクリーニング方法及びスクリーニング用試薬
US7033790B2 (en) 2001-04-03 2006-04-25 Curagen Corporation Proteins and nucleic acids encoding same
US7186818B2 (en) 2001-04-26 2007-03-06 Immunex Corporation DNA encoding soluble variants of human OX2 receptors
AU2002259209A1 (en) 2001-05-11 2002-11-25 Adipogenix, Inc. Methods and reagents for identifying insulin response modulators and therapeutic uses therefor
WO2002092756A2 (en) 2001-05-15 2002-11-21 Rappaport Family Institute For Research In The Medical Sciences Insulin producing cells derived from human embryonic stem cells
EP2161578A1 (en) 2001-05-29 2010-03-10 Pride Proteomics A/S Proteins in diabetes proteome analysis
US20030092028A1 (en) 2001-06-01 2003-05-15 Yuanhong Ma Methods and Reagents For Diagnosis and Treatment of Insulin Resistance and Related Condition
DE60226343T2 (de) 2001-06-08 2009-06-18 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Zur glucoseregulierten produktion von menschlichem insulin in somatischen zelllinien geeignete nukleinsäurekonstrukte
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102300D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
US20030120040A1 (en) 2001-06-29 2003-06-26 Genentech, Inc. Secreted and Transmembrane polypeptides and nucleic acids encoding the same
ATE433996T1 (de) 2001-07-03 2009-07-15 Genentech Inc Humane dr4-antikörper und deren anwendungen
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US20030138416A1 (en) 2001-12-03 2003-07-24 Jesper Lau Use of glucokinase activator in combination with a glucagon antagonist for treating type 2 diabetes
JP2005526702A (ja) 2001-12-03 2005-09-08 ノボ ノルディスク アクティーゼルスカブ グルカゴンアンタゴニストとの組み合わせにおける2型糖尿病治療のためのグルコキナーゼ活性化剤の使用
US20030023042A1 (en) 2001-12-06 2003-01-30 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6911545B2 (en) 2001-12-19 2005-06-28 Hoffman-La Roche Inc. Crystals of glucokinase and methods of growing them
DE10162730A1 (de) 2001-12-20 2003-07-03 Degussa Allele des glk-Gens aus coryneformen Bakterien
WO2003055482A1 (en) 2001-12-21 2003-07-10 Novo Nordisk A/S Amide derivatives as gk activators
EP1572149A2 (en) 2002-03-07 2005-09-14 The Forsyth Institute Immunogenicity of glucan binding protein
WO2003080585A1 (en) 2002-03-26 2003-10-02 Banyu Pharmaceutical Co., Ltd. Novel aminobenzamide derivative
US20030232370A1 (en) 2002-04-22 2003-12-18 Trifiro Mark A. Glucose sensor and uses thereof
AU2003232204B8 (en) 2002-04-26 2009-07-30 F. Hoffmann-La Roche Ag Substituted phenylacetamides and their use as glucokinase activators
AU2003290507A1 (en) * 2002-05-10 2004-04-08 Cytokinetics, Inc. Compounds, compositions and methods
CA2490023A1 (en) 2002-05-16 2003-11-27 Banyu Pharmaceutical Co., Ltd. Crystal of glucokinase protein, and method for drug design using the crystal
AU2003243427A1 (en) 2002-06-04 2003-12-19 Metabolex, Inc. Methods of diagnosing and treating diabetes and insulin resistance
JP2005535302A (ja) 2002-06-04 2005-11-24 メタボレックス インコーポレーティッド 糖尿病およびインスリン抵抗性の診断および治療のための方法
AU2003240556A1 (en) 2002-06-04 2003-12-19 Metabolex, Inc. Methods of diagnosing and treating diabetes and insulin resistance
AU2003237483A1 (en) 2002-06-05 2003-12-22 Metabolex, Inc. Methods of diagnosing and treating diabetes and insulin resistance
EP1578991A2 (en) 2002-06-05 2005-09-28 Metabolex, Inc. Methods of diagnosing & treating diabetes and insulin resistance
WO2003105879A1 (en) 2002-06-13 2003-12-24 Metabolex, Inc. Compositions and methods for preventing, treating and diagnosing diabetes
PL215132B1 (pl) 2002-06-27 2013-10-31 Novo Nordisk As Pochodna arylokarbonylowa jako srodek terapeutyczny, jej zastosowanie i kompozycja farmaceutyczna ja zawierajaca
KR100442832B1 (ko) 2002-07-10 2004-08-02 삼성전자주식회사 다중 중합효소 연쇄반응에 의한 mody2 유전자의증폭을 위한 프라이머 세트
US20040197792A1 (en) 2002-07-15 2004-10-07 Sugen, Inc. Novel Kinases
US7087631B2 (en) 2002-07-18 2006-08-08 Inotek Pharmaceuticals Corporation Aryltetrazole compounds, and compositions thereof
US20040132679A1 (en) 2002-09-03 2004-07-08 Baylor College Of Medicine Induction of pancreatic islet formation
ES2293005T3 (es) 2002-10-03 2008-03-16 F. Hoffmann-La Roche Ag Indol-3-carboxamidas como activadores de la glucocinasa.
WO2004050645A1 (en) 2002-10-03 2004-06-17 Novartis Ag Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes
TW200504033A (en) 2002-10-23 2005-02-01 Procter & Gamble Melanocortin receptor ligands
US20040108226A1 (en) 2002-10-28 2004-06-10 Constantin Polychronakos Continuous glucose quantification device and method
WO2004039954A2 (en) 2002-10-28 2004-05-13 Joslin Diabetes Center, Inc. Type 2 diabetes mellitus genes
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
MY141521A (en) 2002-12-12 2010-05-14 Hoffmann La Roche 5-substituted-six-membered heteroaromatic glucokinase activators
DE10258885A1 (de) 2002-12-17 2004-07-15 Aventis Pharma Deutschland Gmbh Verfahren zur Generierung eines gentechnisch veränderten Organismus
WO2004063179A1 (en) 2003-01-06 2004-07-29 Eli Lilly And Company Substituted arylcyclopropylacetamides as glucokinase activators
WO2004063194A1 (en) 2003-01-06 2004-07-29 Eli Lilly And Company Heteroaryl compounds
US20050031605A1 (en) 2003-02-03 2005-02-10 Bunn Howard F. Compositions and methods of treating diabetes
US7262196B2 (en) 2003-02-11 2007-08-28 Prosidion Limited Tri(cyclo) substituted amide glucokinase activator compounds
PL378117A1 (pl) 2003-02-11 2006-03-06 Prosidion Limited Tricyklopodstawione związki amidowe
BRPI0407283A (pt) 2003-02-13 2006-01-31 Banyu Pharma Co Ltd Composto, composição farmacêutica, e, agente ativador de glucoquinase, agentes terapêuticos e/ou agentes preventivos para diabetes melito e obesidade
KR20050105488A (ko) 2003-02-26 2005-11-04 반유 세이야꾸 가부시끼가이샤 헤테로아릴카바모일벤젠 유도체
US7166692B2 (en) 2003-03-04 2007-01-23 Canbrex Bio Science Walkersville, Inc. Intracellular delivery of small molecules, proteins, and nucleic acids
US20040180845A1 (en) 2003-03-13 2004-09-16 Newgard Christopher B. Methods and compositions for modulating glycogen synthesis and breakdown
US20040185548A1 (en) 2003-03-17 2004-09-23 Qun-Sheng Ji Hybrid receptors for efficient assay of modulators of receptor protein-tyrosine kinases
US20040198969A1 (en) 2003-04-01 2004-10-07 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
WO2004096806A1 (ja) * 2003-04-30 2004-11-11 Sumitomo Pharmaceuticals Co. Ltd. 縮合イミダゾール誘導体
US7179613B2 (en) 2003-05-05 2007-02-20 Vanderbilt University Methods of screening for a candidate modulator of glucokinase
AU2004235872A1 (en) 2003-05-09 2004-11-18 Novo Nordisk A/S Peptides for use in treating obesity
WO2004101505A1 (en) 2003-05-14 2004-11-25 Novo Nordisk A/S Novel compounds for treatment of obesity
US20050008691A1 (en) 2003-05-14 2005-01-13 Arturo Siles Ortega Bicalutamide compositions
WO2005009446A1 (en) 2003-07-17 2005-02-03 Cotherix, Inc. Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome
RS20060320A (sr) 2003-08-01 2008-08-07 Janssen Pharmaceutica N.V., Supstituisani indazol-o-glukozidi
AU2004261663A1 (en) 2003-08-01 2005-02-10 Janssen Pharmaceutica N.V. Substituted benzimidazole-, benztriazole-, and benzimidazolone-O-glucosides
WO2005014534A1 (en) 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
WO2005030032A2 (en) 2003-09-22 2005-04-07 The Regents Of The University Of Colorado Use of islet glucose-6-phosphatase related protein as a diagnostic tool and therapeutic target for autoimmune diabetes
GB0327761D0 (en) 2003-11-29 2003-12-31 Astrazeneca Ab Compounds
GB0327760D0 (en) 2003-11-29 2003-12-31 Astrazeneca Ab Compounds
CN101035767A (zh) * 2004-08-12 2007-09-12 普洛希典有限公司 被取代的苯乙酰胺及其作为葡糖激酶激活剂的用途
AU2005288080B2 (en) * 2004-09-28 2011-10-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril compound
WO2007104034A2 (en) * 2006-03-08 2007-09-13 Takeda San Diego, Inc. Glucokinase activators
CA2644716A1 (en) * 2006-03-13 2007-09-27 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
DK2044026T3 (da) * 2006-06-22 2014-06-30 Prana Biotechnology Ltd Fremgangsmde til behandling af cerebral glioma tumor
US20110130365A1 (en) * 2008-07-29 2011-06-02 Benbow John W Fluorinated Heteroaryls

Similar Documents

Publication Publication Date Title
JP2010514677A5 (cg-RX-API-DMAC7.html)
JP2009531309A5 (cg-RX-API-DMAC7.html)
ES2344347T3 (es) Derivados de cianopiridina novedosos utiles en el tratamiento de cancer y otros trastornos.
JP6759100B2 (ja) 治療用阻害化合物
CA2462289C (en) Heteroaryl substituted tetrazole modulators of metabotropic glutamate receptor-5
KR101643781B1 (ko) 헤지호그 신호전달에 대한 피리딜 억제제
JP5556924B2 (ja) 緑内障の治療又は予防のための医薬組成物
JP2007519735A5 (cg-RX-API-DMAC7.html)
CA2718393A1 (en) Pyridylaminoacetic acid compound
JP2005526814A5 (cg-RX-API-DMAC7.html)
WO2005117867A2 (en) Monocyclic heterocycles as kinase inhibitors
RU2012126989A (ru) 2-амино-5,5-дифтор-5,6-дигидро-4н-оксазины в качестве ингибиторов васе 1 и(или) васе 2
JP2007508346A5 (cg-RX-API-DMAC7.html)
TW200529830A (en) A thiazole derivative
MXPA05009102A (es) Derivados de piridina sustituida utiles en el tratamiento del cancer y otros trastornos.
JP2011520915A5 (cg-RX-API-DMAC7.html)
CA2599974C (en) Pyridine-2-carboxamide derivatives as mglur5 antagonists
JP2011503230A5 (cg-RX-API-DMAC7.html)
JP2019505595A5 (cg-RX-API-DMAC7.html)
EP1608639A2 (en) Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders
JP2020512401A5 (cg-RX-API-DMAC7.html)
JP2008526840A5 (cg-RX-API-DMAC7.html)
TWI794844B (zh) 包含經由鏈接子連接之2或更多芳基或雜芳基的新穎羰基亞肼基二氰化物化合物及其用途
JP2023527698A (ja) 新規マロニトリル誘導体
JP2007527899A5 (cg-RX-API-DMAC7.html)