JP2010514676A5 - - Google Patents
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- JP2010514676A5 JP2010514676A5 JP2009542940A JP2009542940A JP2010514676A5 JP 2010514676 A5 JP2010514676 A5 JP 2010514676A5 JP 2009542940 A JP2009542940 A JP 2009542940A JP 2009542940 A JP2009542940 A JP 2009542940A JP 2010514676 A5 JP2010514676 A5 JP 2010514676A5
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- 0 *c(nc1Cl)ncc1C#N Chemical compound *c(nc1Cl)ncc1C#N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87630706P | 2006-12-21 | 2006-12-21 | |
| US60/876,307 | 2006-12-21 | ||
| US92229107P | 2007-04-06 | 2007-04-06 | |
| US60/922,291 | 2007-04-06 | ||
| US94770707P | 2007-07-03 | 2007-07-03 | |
| US60/947,707 | 2007-07-03 | ||
| US98901407P | 2007-11-19 | 2007-11-19 | |
| US60/989,014 | 2007-11-19 | ||
| PCT/US2007/026190 WO2008079346A1 (en) | 2006-12-21 | 2007-12-21 | 5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013227246A Division JP2014051516A (ja) | 2006-12-21 | 2013-10-31 | タンパク質キナーゼ阻害剤として有用な5−シアノ−4−(ピロロ[2,3b]ピリジン−3−イル)−ピリミジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010514676A JP2010514676A (ja) | 2010-05-06 |
| JP2010514676A5 true JP2010514676A5 (https=) | 2011-06-30 |
| JP5406039B2 JP5406039B2 (ja) | 2014-02-05 |
Family
ID=39272205
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009542940A Expired - Fee Related JP5406039B2 (ja) | 2006-12-21 | 2007-12-21 | タンパク質キナーゼ阻害剤として有用な5−シアノ−4−(ピロロ[2,3b]ピリジン−3−イル)−ピリミジン誘導体 |
| JP2013227246A Pending JP2014051516A (ja) | 2006-12-21 | 2013-10-31 | タンパク質キナーゼ阻害剤として有用な5−シアノ−4−(ピロロ[2,3b]ピリジン−3−イル)−ピリミジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013227246A Pending JP2014051516A (ja) | 2006-12-21 | 2013-10-31 | タンパク質キナーゼ阻害剤として有用な5−シアノ−4−(ピロロ[2,3b]ピリジン−3−イル)−ピリミジン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US8247421B2 (https=) |
| EP (2) | EP2815750A1 (https=) |
| JP (2) | JP5406039B2 (https=) |
| KR (1) | KR20090091350A (https=) |
| CN (1) | CN101678022A (https=) |
| AR (1) | AR064675A1 (https=) |
| AU (1) | AU2007338754A1 (https=) |
| CA (1) | CA2673472A1 (https=) |
| MX (1) | MX2009006700A (https=) |
| NO (1) | NO20092668L (https=) |
| NZ (1) | NZ577798A (https=) |
| TW (1) | TW200838517A (https=) |
| WO (1) | WO2008079346A1 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2364495T3 (es) | 2005-02-03 | 2011-09-05 | The General Hospital Corporation | Método para tratar cáncer resistente a gefitinib. |
| WO2006127587A1 (en) * | 2005-05-20 | 2006-11-30 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| JP2009514870A (ja) | 2005-11-04 | 2009-04-09 | ワイス | mTORインヒビター、ハーセプチン、および/またはHKI−272の抗悪性腫瘍性組み合わせ |
| AU2007338754A1 (en) * | 2006-12-21 | 2008-07-03 | Vertex Pharmaceuticals Incorporated | 5-cyan0-4- (pyrrolo [2, 3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
| CN101778825A (zh) * | 2007-03-22 | 2010-07-14 | 沃泰克斯药物股份有限公司 | 适用作詹纳斯激酶抑制剂的n-杂环类化合物 |
| PL2201012T3 (pl) | 2007-10-11 | 2014-11-28 | Astrazeneca Ab | Pochodne pirolo[2,3-d]pirymidyny jako inhibitory kinazy białkowej b |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| WO2009145814A2 (en) * | 2008-03-10 | 2009-12-03 | Vertex Pharmaceuticals Incorporated | Pyrimidines and pyridines useful as inhibitors of protein kinases |
| ES2692769T3 (es) | 2008-06-17 | 2018-12-05 | Wyeth Llc | Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina |
| CN105147713A (zh) | 2008-08-04 | 2015-12-16 | 惠氏有限责任公司 | 4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合 |
| WO2010106988A1 (ja) | 2009-03-17 | 2010-09-23 | 第一三共株式会社 | アミド誘導体 |
| SG174382A1 (en) | 2009-04-06 | 2011-11-28 | Wyeth Llc | Treatment regimen utilizing neratinib for breast cancer |
| CN102438993A (zh) * | 2009-05-19 | 2012-05-02 | 陶氏益农公司 | 用于控制真菌的化合物和方法 |
| RS57869B1 (sr) * | 2009-06-17 | 2018-12-31 | Vertex Pharma | Inhibitori replikacije virusa gripa |
| EP2464633A1 (en) * | 2009-08-14 | 2012-06-20 | Boehringer Ingelheim International GmbH | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| MX2013006840A (es) | 2010-12-16 | 2014-01-31 | Vertex Pharma | Inhibidores de la replicacion de los virus de la influenza. |
| AU2011343642A1 (en) | 2010-12-16 | 2013-05-02 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| EP2694056B1 (en) | 2011-04-01 | 2019-10-16 | AstraZeneca AB | Therapeutic treatment |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| PH12014500943A1 (en) | 2011-11-30 | 2014-06-30 | Astrazeneca Ab | Combination treatment of cancer |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| WO2014004543A1 (en) * | 2012-06-25 | 2014-01-03 | Mone Zaidi Consulting, Inc. | Combination cancer therapy using bisphosphonates and anti-egfr agents |
| EP2935248B1 (en) * | 2012-12-21 | 2018-02-28 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| GB2515785A (en) * | 2013-07-03 | 2015-01-07 | Redx Pharma Ltd | Compounds |
| CN104540820B (zh) * | 2013-07-16 | 2016-12-21 | 杭州普晒医药科技有限公司 | 阿法替尼酸加成盐及其晶型、其制备方法及药物组合物 |
| RS59144B1 (sr) | 2013-11-13 | 2019-09-30 | Vertex Pharma | Inhibitori replikacije virusa influence |
| HRP20181272T1 (hr) | 2013-11-13 | 2018-10-05 | Vertex Pharmaceuticals Incorporated | Postupci priprave inhibitora replikacije virusa influence |
| KR102359214B1 (ko) | 2014-04-04 | 2022-02-07 | 델 마 파마슈티컬스 | 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체 |
| JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤を調製する方法 |
| JP6857617B2 (ja) | 2015-05-13 | 2021-04-14 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤 |
| WO2016210345A1 (en) * | 2015-06-25 | 2016-12-29 | The California Institute For Biomedical Research | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 |
| US11497813B2 (en) * | 2015-11-02 | 2022-11-15 | Biovinc, Llc | Bortezomib conjugates and methods using same |
| WO2017094026A1 (en) | 2015-11-30 | 2017-06-08 | Council Of Scientific & Industrial Research | 3-pyrimidinyl pyrrolo [2,3-b] pyridine as new anticancer agents and the process for the preparation thereof |
| IL322315A (en) | 2019-05-14 | 2025-09-01 | Provention Bio Inc | Methods and preparations for preventing type 1 diabetes |
| CN110372713B (zh) * | 2019-08-15 | 2022-05-17 | 广州市汉普医药有限公司 | 一种普拉洛芬的精制纯化方法 |
| MX2022007265A (es) * | 2019-12-20 | 2022-09-09 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
| CN115605460A (zh) | 2020-04-29 | 2023-01-13 | 普莱希科公司(Us) | 杂环化合物的合成 |
| AU2021287998B2 (en) | 2020-06-11 | 2026-03-12 | Benaroya Research Institute At Virginia Mason | Methods and compositions for preventing type 1 diabetes |
| AU2022264775A1 (en) * | 2021-04-26 | 2023-11-09 | Ohio State Innovation Foundation | Lipid nanomaterials and uses thereof |
| US12565529B2 (en) | 2021-05-24 | 2026-03-03 | Provention Bio, Inc. | Methods for treating type 1 diabetes |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
| WO2025228376A1 (zh) * | 2024-04-30 | 2025-11-06 | 阿诺医药 (新加坡) 有限公司 | Cyclin K降解剂药物及其抗体偶联物 |
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| NZ221717A (en) | 1986-09-10 | 1990-08-28 | Sandoz Ltd | Azaindole and indolizine derivatives and pharmaceutical compositions |
| JP2779403B2 (ja) | 1988-11-29 | 1998-07-23 | 日本バイエルアグロケム株式会社 | 殺虫性ニトロ化合物 |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| FR2687402B1 (fr) | 1992-02-14 | 1995-06-30 | Lipha | Nouveaux azaindoles, procedes de preparation et medicaments les contenant. |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| JPH10510510A (ja) | 1994-06-09 | 1998-10-13 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体拮抗物質 |
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| AU2494300A (en) | 1999-01-07 | 2000-07-24 | American Home Products Corporation | 3,4-dihydro-2h-benzo(1,4)oxazine derivatives |
| US6265403B1 (en) | 1999-01-20 | 2001-07-24 | Merck & Co., Inc. | Angiogenesis inhibitors |
| US20030153560A1 (en) * | 1999-04-23 | 2003-08-14 | Salituro Francesco G. | Inhibitors of c-Jun N-terminal kinases (JNK) |
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| AU2007338754A1 (en) * | 2006-12-21 | 2008-07-03 | Vertex Pharmaceuticals Incorporated | 5-cyan0-4- (pyrrolo [2, 3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
| MX2009009592A (es) | 2007-03-09 | 2009-11-10 | Vertex Pharma | Aminopiridinas utiles como inhibidores de proteinas cinasas. |
| ATE526328T1 (de) | 2007-03-09 | 2011-10-15 | Vertex Pharma | Als inhibitoren von proteinkinasen geeignete aminopyrimidine |
| MX2009009590A (es) | 2007-03-09 | 2009-11-10 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de proteinas cinasas. |
| CA2704266A1 (en) * | 2007-11-02 | 2009-06-11 | Vertex Pharmaceuticals Incorporated | [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta |
| WO2009145814A2 (en) | 2008-03-10 | 2009-12-03 | Vertex Pharmaceuticals Incorporated | Pyrimidines and pyridines useful as inhibitors of protein kinases |
-
2007
- 2007-12-21 AU AU2007338754A patent/AU2007338754A1/en not_active Abandoned
- 2007-12-21 CN CN200780051641A patent/CN101678022A/zh active Pending
- 2007-12-21 TW TW096149620A patent/TW200838517A/zh unknown
- 2007-12-21 MX MX2009006700A patent/MX2009006700A/es not_active Application Discontinuation
- 2007-12-21 EP EP14167221.2A patent/EP2815750A1/en not_active Withdrawn
- 2007-12-21 US US12/448,489 patent/US8247421B2/en not_active Expired - Fee Related
- 2007-12-21 AR ARP070105844A patent/AR064675A1/es not_active Application Discontinuation
- 2007-12-21 JP JP2009542940A patent/JP5406039B2/ja not_active Expired - Fee Related
- 2007-12-21 NZ NZ577798A patent/NZ577798A/en not_active IP Right Cessation
- 2007-12-21 EP EP07867948.7A patent/EP2124951B1/en not_active Not-in-force
- 2007-12-21 WO PCT/US2007/026190 patent/WO2008079346A1/en not_active Ceased
- 2007-12-21 CA CA002673472A patent/CA2673472A1/en not_active Abandoned
- 2007-12-21 KR KR1020097015174A patent/KR20090091350A/ko not_active Withdrawn
-
2009
- 2009-07-13 NO NO20092668A patent/NO20092668L/no not_active Application Discontinuation
-
2012
- 2012-05-22 US US13/477,663 patent/US8530489B2/en not_active Expired - Fee Related
-
2013
- 2013-08-07 US US13/961,218 patent/US8962642B2/en not_active Expired - Fee Related
- 2013-10-31 JP JP2013227246A patent/JP2014051516A/ja active Pending
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