JP2010514676A5 - - Google Patents
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- JP2010514676A5 JP2010514676A5 JP2009542940A JP2009542940A JP2010514676A5 JP 2010514676 A5 JP2010514676 A5 JP 2010514676A5 JP 2009542940 A JP2009542940 A JP 2009542940A JP 2009542940 A JP2009542940 A JP 2009542940A JP 2010514676 A5 JP2010514676 A5 JP 2010514676A5
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- 0 *c(nc1Cl)ncc1C#N Chemical compound *c(nc1Cl)ncc1C#N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87630706P | 2006-12-21 | 2006-12-21 | |
| US60/876,307 | 2006-12-21 | ||
| US92229107P | 2007-04-06 | 2007-04-06 | |
| US60/922,291 | 2007-04-06 | ||
| US94770707P | 2007-07-03 | 2007-07-03 | |
| US60/947,707 | 2007-07-03 | ||
| US98901407P | 2007-11-19 | 2007-11-19 | |
| US60/989,014 | 2007-11-19 | ||
| PCT/US2007/026190 WO2008079346A1 (en) | 2006-12-21 | 2007-12-21 | 5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013227246A Division JP2014051516A (ja) | 2006-12-21 | 2013-10-31 | タンパク質キナーゼ阻害剤として有用な5−シアノ−4−(ピロロ[2,3b]ピリジン−3−イル)−ピリミジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010514676A JP2010514676A (ja) | 2010-05-06 |
| JP2010514676A5 true JP2010514676A5 (https=) | 2011-06-30 |
| JP5406039B2 JP5406039B2 (ja) | 2014-02-05 |
Family
ID=39272205
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009542940A Expired - Fee Related JP5406039B2 (ja) | 2006-12-21 | 2007-12-21 | タンパク質キナーゼ阻害剤として有用な5−シアノ−4−(ピロロ[2,3b]ピリジン−3−イル)−ピリミジン誘導体 |
| JP2013227246A Pending JP2014051516A (ja) | 2006-12-21 | 2013-10-31 | タンパク質キナーゼ阻害剤として有用な5−シアノ−4−(ピロロ[2,3b]ピリジン−3−イル)−ピリミジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013227246A Pending JP2014051516A (ja) | 2006-12-21 | 2013-10-31 | タンパク質キナーゼ阻害剤として有用な5−シアノ−4−(ピロロ[2,3b]ピリジン−3−イル)−ピリミジン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US8247421B2 (https=) |
| EP (2) | EP2124951B1 (https=) |
| JP (2) | JP5406039B2 (https=) |
| KR (1) | KR20090091350A (https=) |
| CN (1) | CN101678022A (https=) |
| AR (1) | AR064675A1 (https=) |
| AU (1) | AU2007338754A1 (https=) |
| CA (1) | CA2673472A1 (https=) |
| MX (1) | MX2009006700A (https=) |
| NO (1) | NO20092668L (https=) |
| NZ (1) | NZ577798A (https=) |
| TW (1) | TW200838517A (https=) |
| WO (1) | WO2008079346A1 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101313702B1 (ko) | 2005-02-03 | 2013-10-04 | 와이어쓰 | 제피티니브 및/또는 에를로티니브 내성암 치료용 약제학적 조성물 |
| EP2354140A1 (en) * | 2005-05-20 | 2011-08-10 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| EP1942937A1 (en) | 2005-11-04 | 2008-07-16 | Wyeth | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
| CN101678022A (zh) * | 2006-12-21 | 2010-03-24 | 弗特克斯药品有限公司 | 可用作蛋白激酶抑制剂的5-氰基-4-(吡咯并[2,3b]吡啶-3-基)嘧啶衍生物 |
| MX2009010127A (es) * | 2007-03-22 | 2009-11-05 | Vertex Pharma | Compuestos utiles como inhibidores de janus cinasas. |
| PL2201012T3 (pl) | 2007-10-11 | 2014-11-28 | Astrazeneca Ab | Pochodne pirolo[2,3-d]pirymidyny jako inhibitory kinazy białkowej b |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| JP2011513483A (ja) * | 2008-03-10 | 2011-04-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン |
| BRPI0914790A2 (pt) | 2008-06-17 | 2015-10-20 | Wyeth Llc | uso de um composto de vinorelbina e um composto de hki-272, composição farmacêutica e produto e kit para o tratamento de neoplasma |
| US8669273B2 (en) | 2008-08-04 | 2014-03-11 | Wyeth Llc | Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine |
| BRPI1014125A2 (pt) | 2009-03-17 | 2016-04-12 | Daiichi Sankyo Co Ltd | composto, composição farmacêutica, e, uso de um composto. |
| DK3000467T3 (da) | 2009-04-06 | 2023-03-27 | Wyeth Llc | Behandling med neratinib mod brystkræft |
| MX2011012343A (es) * | 2009-05-19 | 2011-12-14 | Dow Agrosciences Llc | Compuestos y metodos para controlar hongos. |
| LT3141252T (lt) | 2009-06-17 | 2018-11-12 | Vertex Pharmaceuticals Inc. | Gripo virusų replikacijos inhibitoriai |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| WO2011018517A1 (en) * | 2009-08-14 | 2011-02-17 | Boehringer Ingelheim International Gmbh | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives |
| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| CN103562205A (zh) | 2010-12-16 | 2014-02-05 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
| EA027506B1 (ru) | 2011-04-01 | 2017-08-31 | Астразенека Аб | Способ лечения рака молочной железы |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| HRP20191982T4 (hr) | 2011-11-30 | 2023-01-06 | Astrazeneca Ab | Kombinacijsko liječenje raka |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| WO2014004543A1 (en) * | 2012-06-25 | 2014-01-03 | Mone Zaidi Consulting, Inc. | Combination cancer therapy using bisphosphonates and anti-egfr agents |
| MX365640B (es) | 2012-12-21 | 2019-06-10 | Plexxikon Inc | Compuestos y metodos para la modulacion de quinasas y sus indicaciones. |
| GB2515785A (en) * | 2013-07-03 | 2015-01-07 | Redx Pharma Ltd | Compounds |
| WO2015007206A1 (zh) * | 2013-07-16 | 2015-01-22 | 杭州普晒医药科技有限公司 | 阿法替尼酸加成盐及其晶型、其制备方法及药物组合物 |
| JP6618901B2 (ja) * | 2013-11-13 | 2019-12-11 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤を調製する方法 |
| LT3068776T (lt) | 2013-11-13 | 2019-08-12 | Vertex Pharmaceuticals Incorporated | Gripo virusų replikacijos inhibitoriai |
| SG11201608303QA (en) | 2014-04-04 | 2016-11-29 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
| EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| WO2016210345A1 (en) * | 2015-06-25 | 2016-12-29 | The California Institute For Biomedical Research | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 |
| CA3003741A1 (en) * | 2015-11-02 | 2017-05-11 | University Of Rochester | Bortezomib conjugates and methods using same |
| EP3383875B1 (en) | 2015-11-30 | 2022-02-09 | Council Of Scientific & Industrial Research | 3-pyrimidinyl pyrrolo [2,3-b] pyridine as anticancer agents and the process for the preparation thereof |
| WO2020232247A1 (en) | 2019-05-14 | 2020-11-19 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| CN110372713B (zh) * | 2019-08-15 | 2022-05-17 | 广州市汉普医药有限公司 | 一种普拉洛芬的精制纯化方法 |
| WO2021222442A1 (en) | 2020-04-29 | 2021-11-04 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| IL298999A (en) | 2020-06-11 | 2023-02-01 | Provention Bio Inc | Methods and compositions for the prevention of type 1 diabetes |
| AU2022264775A1 (en) * | 2021-04-26 | 2023-11-09 | Ohio State Innovation Foundation | Lipid nanomaterials and uses thereof |
| JP2024520444A (ja) | 2021-05-24 | 2024-05-24 | プロヴェンション・バイオ・インコーポレイテッド | 1型糖尿病を治療するための方法 |
| US12084453B2 (en) | 2021-12-10 | 2024-09-10 | Incyte Corporation | Bicyclic amines as CDK12 inhibitors |
| WO2025228376A1 (zh) * | 2024-04-30 | 2025-11-06 | 阿诺医药 (新加坡) 有限公司 | Cyclin K降解剂药物及其抗体偶联物 |
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| CN101678022A (zh) | 2006-12-21 | 2010-03-24 | 弗特克斯药品有限公司 | 可用作蛋白激酶抑制剂的5-氰基-4-(吡咯并[2,3b]吡啶-3-基)嘧啶衍生物 |
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| TW200924762A (en) * | 2007-11-02 | 2009-06-16 | Vertex Pharma | Kinase inhibitors |
| JP2011513483A (ja) | 2008-03-10 | 2011-04-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン |
-
2007
- 2007-12-21 CN CN200780051641A patent/CN101678022A/zh active Pending
- 2007-12-21 TW TW096149620A patent/TW200838517A/zh unknown
- 2007-12-21 JP JP2009542940A patent/JP5406039B2/ja not_active Expired - Fee Related
- 2007-12-21 AR ARP070105844A patent/AR064675A1/es not_active Application Discontinuation
- 2007-12-21 EP EP07867948.7A patent/EP2124951B1/en not_active Not-in-force
- 2007-12-21 NZ NZ577798A patent/NZ577798A/en not_active IP Right Cessation
- 2007-12-21 AU AU2007338754A patent/AU2007338754A1/en not_active Abandoned
- 2007-12-21 EP EP14167221.2A patent/EP2815750A1/en not_active Withdrawn
- 2007-12-21 KR KR1020097015174A patent/KR20090091350A/ko not_active Withdrawn
- 2007-12-21 US US12/448,489 patent/US8247421B2/en not_active Expired - Fee Related
- 2007-12-21 MX MX2009006700A patent/MX2009006700A/es not_active Application Discontinuation
- 2007-12-21 WO PCT/US2007/026190 patent/WO2008079346A1/en not_active Ceased
- 2007-12-21 CA CA002673472A patent/CA2673472A1/en not_active Abandoned
-
2009
- 2009-07-13 NO NO20092668A patent/NO20092668L/no not_active Application Discontinuation
-
2012
- 2012-05-22 US US13/477,663 patent/US8530489B2/en not_active Expired - Fee Related
-
2013
- 2013-08-07 US US13/961,218 patent/US8962642B2/en not_active Expired - Fee Related
- 2013-10-31 JP JP2013227246A patent/JP2014051516A/ja active Pending
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