JP2010503717A5

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Publication number: JP2010503717A5
Authority: JP; Japan
Prior art keywords: cancer; inhibitors; derivatives; cell; use according
Prior art date: 2007-09-14
Legal status : Pending

Application number

JP2009528693A

Other languages

English (en)

Japanese (ja)

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JP2010503717A (ja

Filing date

2007-09-14

Publication date

2010-11-04

2007-09-14 Application filed filed Critical

2007-09-14 Priority claimed from PCT/EP2007/059735 external-priority patent/WO2008034776A1/en

2010-02-04 Publication of JP2010503717A publication Critical patent/JP2010503717A/ja

2010-11-04 Publication of JP2010503717A5 publication Critical patent/JP2010503717A5/ja

Status Pending legal-status Critical Current

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206010028980 Neoplasm Diseases 0.000 claims 32
-1 platinum compounds Compounds Chemical class 0.000 claims 24
201000011510 cancer Diseases 0.000 claims 20
239000003112 inhibitor Substances 0.000 claims 18
230000035772 mutation Effects 0.000 claims 12
210000004027 cell Anatomy 0.000 claims 10
102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 8
108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 8
YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 8
150000003384 small molecules Chemical class 0.000 claims 8
150000001875 compounds Chemical class 0.000 claims 5
239000003814 drug Substances 0.000 claims 5
208000002154 non-small cell lung carcinoma Diseases 0.000 claims 5
208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 5
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AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 3
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OEWYWFJWBZNJJG-UHFFFAOYSA-N 1-(aziridin-1-yl)-3-(2-nitroimidazol-1-yl)propan-2-ol Chemical compound C1=CN=C([N+]([O-])=O)N1CC(O)CN1CC1 OEWYWFJWBZNJJG-UHFFFAOYSA-N 0.000 claims 2
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YEZNLOUZAIOMLT-UHFFFAOYSA-N tolfenamic acid Chemical compound CC1=C(Cl)C=CC=C1NC1=CC=CC=C1C(O)=O YEZNLOUZAIOMLT-UHFFFAOYSA-N 0.000 claims 1
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RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 claims 1
229960004824 triptorelin Drugs 0.000 claims 1
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MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 claims 1
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LLDWLPRYLVPDTG-UHFFFAOYSA-N vatalanib succinate Chemical compound OC(=O)CCC(O)=O.C1=CC(Cl)=CC=C1NC(C1=CC=CC=C11)=NN=C1CC1=CC=NC=C1 LLDWLPRYLVPDTG-UHFFFAOYSA-N 0.000 claims 1
229960003048 vinblastine Drugs 0.000 claims 1
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OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
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CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 claims 1
229960002166 vinorelbine tartrate Drugs 0.000 claims 1
GBABOYUKABKIAF-IWWDSPBFSA-N vinorelbinetartrate Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC(C23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-IWWDSPBFSA-N 0.000 claims 1
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210000001325 yolk sac Anatomy 0.000 claims 1
229910052725 zinc Inorganic materials 0.000 claims 1
239000011701 zinc Substances 0.000 claims 1
229950011303 zoledronic acid monohydrate Drugs 0.000 claims 1
229960003414 zomepirac Drugs 0.000 claims 1
ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 claims 1

JP2009528693A 2006-09-18 2007-09-14 Ｅｇｆｒ変異を有する腫瘍を治療するための方法 Pending JP2010503717A (ja)