PL2068880T3 - Sposób leczenia raka z mutacjami EGFR - Google Patents
Sposób leczenia raka z mutacjami EGFRInfo
- Publication number
- PL2068880T3 PL2068880T3 PL07820235T PL07820235T PL2068880T3 PL 2068880 T3 PL2068880 T3 PL 2068880T3 PL 07820235 T PL07820235 T PL 07820235T PL 07820235 T PL07820235 T PL 07820235T PL 2068880 T3 PL2068880 T3 PL 2068880T3
- Authority
- PL
- Poland
- Prior art keywords
- egfr
- treatment
- tumor
- hki
- cancer
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 6
- 230000035772 mutation Effects 0.000 title abstract 5
- 201000011510 cancer Diseases 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 108060006698 EGF receptor Proteins 0.000 title 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 abstract 4
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 abstract 4
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 abstract 4
- ULXXDDBFHOBEHA-ONEGZZNKSA-N Afatinib Chemical compound N1=CN=C2C=C(OC3COCC3)C(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 ULXXDDBFHOBEHA-ONEGZZNKSA-N 0.000 abstract 3
- 229940121647 egfr inhibitor Drugs 0.000 abstract 2
- 230000002427 irreversible effect Effects 0.000 abstract 2
- NERXPXBELDBEPZ-RMKNXTFCSA-N (e)-n-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide Chemical compound C=12C=C(NC(=O)\C=C\CN(C)C)C(OCC)=CC2=NC=C(C#N)C=1NC(C=C1Cl)=CC=C1OCC1=CC=CC(F)=C1 NERXPXBELDBEPZ-RMKNXTFCSA-N 0.000 abstract 1
- 229940125497 HER2 kinase inhibitor Drugs 0.000 abstract 1
- ULXXDDBFHOBEHA-INIZCTEOSA-N N-[4-(3-chloro-4-fluoroanilino)-7-[[(3S)-3-oxolanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide Chemical compound N1=CN=C2C=C(O[C@@H]3COCC3)C(NC(=O)C=CCN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 ULXXDDBFHOBEHA-INIZCTEOSA-N 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 229960001686 afatinib Drugs 0.000 abstract 1
- ULXXDDBFHOBEHA-CWDCEQMOSA-N afatinib Chemical compound N1=CN=C2C=C(O[C@@H]3COCC3)C(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- OMZCMEYTWSXEPZ-UHFFFAOYSA-N canertinib Chemical compound C1=C(Cl)C(F)=CC=C1NC1=NC=NC2=CC(OCCCN3CCOCC3)=C(NC(=O)C=C)C=C12 OMZCMEYTWSXEPZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229950008835 neratinib Drugs 0.000 abstract 1
- ZNHPZUKZSNBOSQ-BQYQJAHWSA-N neratinib Chemical compound C=12C=C(NC\C=C\CN(C)C)C(OCC)=CC2=NC=C(C#N)C=1NC(C=C1Cl)=CC=C1OCC1=CC=CC=N1 ZNHPZUKZSNBOSQ-BQYQJAHWSA-N 0.000 abstract 1
- WVUNYSQLFKLYNI-AATRIKPKSA-N pelitinib Chemical compound C=12C=C(NC(=O)\C=C\CN(C)C)C(OCC)=CC2=NC=C(C#N)C=1NC1=CC=C(F)C(Cl)=C1 WVUNYSQLFKLYNI-AATRIKPKSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011363 radioimmunotherapy Methods 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 238000002271 resection Methods 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06120856 | 2006-09-18 | ||
| EP07101505 | 2007-01-31 | ||
| EP07820235A EP2068880B1 (en) | 2006-09-18 | 2007-09-14 | Method for treating cancer harboring egfr mutations |
| PCT/EP2007/059735 WO2008034776A1 (en) | 2006-09-18 | 2007-09-14 | Method for treating cancer harboring egfr mutations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2068880T3 true PL2068880T3 (pl) | 2012-09-28 |
Family
ID=38698376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07820235T PL2068880T3 (pl) | 2006-09-18 | 2007-09-14 | Sposób leczenia raka z mutacjami EGFR |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8877764B2 (https=) |
| EP (1) | EP2068880B1 (https=) |
| JP (1) | JP2010503717A (https=) |
| KR (1) | KR20090074202A (https=) |
| AT (1) | ATE552835T1 (https=) |
| AU (1) | AU2007299080B2 (https=) |
| BR (1) | BRPI0717586A2 (https=) |
| CA (1) | CA2663599A1 (https=) |
| CY (1) | CY1112896T1 (https=) |
| DK (1) | DK2068880T3 (https=) |
| ES (1) | ES2385613T3 (https=) |
| IL (1) | IL197605A0 (https=) |
| MX (1) | MX2009002710A (https=) |
| NZ (1) | NZ576065A (https=) |
| PL (1) | PL2068880T3 (https=) |
| PT (1) | PT2068880E (https=) |
| RU (1) | RU2492864C2 (https=) |
| SI (1) | SI2068880T1 (https=) |
| WO (1) | WO2008034776A1 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE04748B1 (et) * | 1999-06-21 | 2006-12-15 | Boehringer Ingelheim Pharma Kg | Bitsüklilised heterotsüklilised ühendid, neid ühendeid sisaldavad ravimid, nende kasutamine ja meetodid nende valmistamiseks |
| US7019012B2 (en) * | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
| US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| DE10349113A1 (de) * | 2003-10-17 | 2005-05-12 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aminocrotonylverbindungen |
| ES2364495T3 (es) | 2005-02-03 | 2011-09-05 | The General Hospital Corporation | Método para tratar cáncer resistente a gefitinib. |
| JP2009514870A (ja) | 2005-11-04 | 2009-04-09 | ワイス | ｍＴＯＲインヒビター、ハーセプチン、および／またはＨＫＩ−２７２の抗悪性腫瘍性組み合わせ |
| PL1948180T3 (pl) * | 2005-11-11 | 2013-09-30 | Boehringer Ingelheim Int | Terapia skojarzona raka polegająca na podawaniu inhibitorów EGFR/HER2 |
| CA2833706C (en) * | 2005-11-11 | 2014-10-21 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
| JP5241513B2 (ja) | 2006-01-26 | 2013-07-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アミノクロトニルアミノ置換キナゾリン誘導体の合成方法 |
| AU2007299080B2 (en) | 2006-09-18 | 2013-04-18 | Boehringer Ingelheim International Gmbh | Method for treating cancer harboring EGFR mutations |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| PE20100252A1 (es) * | 2008-06-06 | 2010-04-12 | Boehringer Ingelheim Int | Nuevas formulaciones farmaceuticas solidas que comprenden dimaleato de 4-[(3-cloro-4-fluorofenil) amino]-6-{[4-(n,n-dimetilamino)-1-oxo-2-buten-1-il] amino}-7-((s)-tetrahidrofuran-3-iloxi)-quinazolina |
| ES2692769T3 (es) | 2008-06-17 | 2018-12-05 | Wyeth Llc | Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina |
| US8426430B2 (en) | 2008-06-30 | 2013-04-23 | Hutchison Medipharma Enterprises Limited | Quinazoline derivatives |
| CN105147713A (zh) | 2008-08-04 | 2015-12-16 | 惠氏有限责任公司 | 4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合 |
| SG174382A1 (en) | 2009-04-06 | 2011-11-28 | Wyeth Llc | Treatment regimen utilizing neratinib for breast cancer |
| WO2010130758A1 (en) * | 2009-05-14 | 2010-11-18 | Boehringer Ingelheim International Gmbh | New combination therapy in treatment of cancer and fibrotic diseases |
| PL2451445T3 (pl) | 2009-07-06 | 2019-09-30 | Boehringer Ingelheim International Gmbh | Sposób suszenia BIBW2992, jego soli i stałych preparatów farmaceutycznych zawierających tę substancję czynną |
| JO3002B1 (ar) | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
| PT2608792T (pt) | 2010-08-26 | 2018-01-15 | Boehringer Ingelheim Int | Métodos de administração de um inibidor de egfr |
| WO2012065071A2 (en) * | 2010-11-12 | 2012-05-18 | The Broad Institute Of Mit And Harvard | Methods of predicting response to egfr antibody therapy |
| US9295676B2 (en) | 2011-03-17 | 2016-03-29 | The Trustees Of The University Of Pennsylvania | Mutation mimicking compounds that bind to the kinase domain of EGFR |
| WO2012125913A1 (en) | 2011-03-17 | 2012-09-20 | The Trustees Of The University Of Pennsylvania | Methods and use of bifunctional enzyme-building clamp-shaped molecules |
| US8828391B2 (en) | 2011-05-17 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Method for EGFR directed combination treatment of non-small cell lung cancer |
| CN102838590B (zh) * | 2011-06-21 | 2014-07-09 | 苏州迈泰生物技术有限公司 | 氨基喹唑啉衍生物及其在制备抗恶性肿瘤药物中的用途 |
| EP2831589B1 (en) | 2012-03-28 | 2018-04-18 | Dana-Farber Cancer Institute, Inc. | C-raf mutants that confer resistance to raf inhibitors |
| JP2015527564A (ja) * | 2012-06-07 | 2015-09-17 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 自己免疫抗体 |
| WO2014004543A1 (en) * | 2012-06-25 | 2014-01-03 | Mone Zaidi Consulting, Inc. | Combination cancer therapy using bisphosphonates and anti-egfr agents |
| CA2907152A1 (en) | 2013-03-15 | 2014-09-25 | The Trustees Of Columbia University In The City Of New York | Fusion proteins and methods thereof |
| CA2918225C (en) | 2013-07-17 | 2023-11-21 | Foundation Medicine, Inc. | Methods of treating urothelial carcinomas |
| US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
| KR20180018551A (ko) | 2015-06-12 | 2018-02-21 | 프레세니어스 카비 온콜로지 리미티드 | 아파티닙 유리 염기 및 아파티닙 디말레에이트의 다형체 형태 |
| FR3039401B1 (fr) * | 2015-07-31 | 2018-07-13 | Les Laboratoires Servier | Nouvelle association entre le 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione et un inhibiteur de la tyr kinase du egfr |
| EP3337461A1 (en) * | 2015-08-21 | 2018-06-27 | Fresenius Kabi Oncology Ltd | Pharmaceutical compositions comprising afatinib |
| EP3446704A1 (en) | 2017-08-24 | 2019-02-27 | Isofol Medical AB | [6r]-mthf - an efficient folate alternative in 5-fluorouracil based chemotherapy |
| CN110022878A (zh) * | 2016-11-03 | 2019-07-16 | 密执安大学评议会 | Egfr/pi3k的小分子双重抑制剂及其用途 |
| MA46852A (fr) * | 2016-11-17 | 2019-09-25 | Univ Texas | Composés à activité antitumorale contre des cellules cancéreuses porteuses de mutations egfr ou her2 exon 20 |
| RU2663929C2 (ru) * | 2016-12-22 | 2018-08-13 | 3СМ Биотрон Инк. | Использование производного соединения тиохромено[2,3-с]хинолин-12-она для лечения немелкоклеточного рака легких |
| US10292984B2 (en) | 2017-02-14 | 2019-05-21 | Isofol Medical Ab | Methods for increasing blood plasma 2′-deoxyuridine (dUrd) and thymidylate synthase inhibition |
| SG11202002060XA (en) * | 2017-09-08 | 2020-04-29 | Univ Colorado Regents | Compounds, compositions and methods for treating or preventing her-driven drug-resistant cancers |
| KR20210144844A (ko) * | 2019-03-29 | 2021-11-30 | 아스트라제네카 아베 | 비-소세포 폐암의 치료에 사용하기 위한 오시머티닙 |
| WO2024022080A1 (zh) * | 2022-07-29 | 2024-02-01 | 东北大学 | Plk4靶向药物在治疗对铂类药物耐药型肿瘤中的应用 |
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| JP2012515184A (ja) * | 2009-01-14 | 2012-07-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 大腸がんの治療方法 |
| PL2451445T3 (pl) | 2009-07-06 | 2019-09-30 | Boehringer Ingelheim International Gmbh | Sposób suszenia BIBW2992, jego soli i stałych preparatów farmaceutycznych zawierających tę substancję czynną |
| JP2013512882A (ja) | 2009-12-07 | 2013-04-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | トリプルネガティブ乳癌の治療に使用するｂｉｂｗ２９９２ |
-
2007
- 2007-09-14 AU AU2007299080A patent/AU2007299080B2/en active Active
- 2007-09-14 AT AT07820235T patent/ATE552835T1/de active
- 2007-09-14 MX MX2009002710A patent/MX2009002710A/es active IP Right Grant
- 2007-09-14 KR KR1020097007757A patent/KR20090074202A/ko not_active Ceased
- 2007-09-14 CA CA002663599A patent/CA2663599A1/en not_active Abandoned
- 2007-09-14 NZ NZ576065A patent/NZ576065A/en unknown
- 2007-09-14 WO PCT/EP2007/059735 patent/WO2008034776A1/en not_active Ceased
- 2007-09-14 PL PL07820235T patent/PL2068880T3/pl unknown
- 2007-09-14 SI SI200730957T patent/SI2068880T1/sl unknown
- 2007-09-14 US US12/441,180 patent/US8877764B2/en active Active
- 2007-09-14 BR BRPI0717586-8A patent/BRPI0717586A2/pt not_active IP Right Cessation
- 2007-09-14 JP JP2009528693A patent/JP2010503717A/ja active Pending
- 2007-09-14 PT PT07820235T patent/PT2068880E/pt unknown
- 2007-09-14 EP EP07820235A patent/EP2068880B1/en not_active Revoked
- 2007-09-14 DK DK07820235.5T patent/DK2068880T3/da active
- 2007-09-14 ES ES07820235T patent/ES2385613T3/es active Active
- 2007-09-14 RU RU2009114414/15A patent/RU2492864C2/ru active
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2009
- 2009-03-16 IL IL197605A patent/IL197605A0/en unknown
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- 2012-07-06 CY CY20121100603T patent/CY1112896T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2068880T3 (da) | 2012-07-23 |
| RU2009114414A (ru) | 2010-12-27 |
| JP2010503717A (ja) | 2010-02-04 |
| BRPI0717586A2 (pt) | 2013-10-29 |
| WO2008034776A1 (en) | 2008-03-27 |
| IL197605A0 (en) | 2009-12-24 |
| SI2068880T1 (sl) | 2012-08-31 |
| ATE552835T1 (de) | 2012-04-15 |
| EP2068880B1 (en) | 2012-04-11 |
| PT2068880E (pt) | 2012-07-12 |
| US8877764B2 (en) | 2014-11-04 |
| CY1112896T1 (el) | 2016-04-13 |
| KR20090074202A (ko) | 2009-07-06 |
| US20090318480A1 (en) | 2009-12-24 |
| CA2663599A1 (en) | 2008-03-27 |
| NZ576065A (en) | 2011-12-22 |
| ES2385613T3 (es) | 2012-07-27 |
| MX2009002710A (es) | 2009-03-25 |
| RU2492864C2 (ru) | 2013-09-20 |
| AU2007299080A1 (en) | 2008-03-27 |
| AU2007299080B2 (en) | 2013-04-18 |
| EP2068880A1 (en) | 2009-06-17 |
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