RU2492864C2 - Способ лечения рака, несущего мутации egfr - Google Patents

Способ лечения рака, несущего мутации egfr Download PDF

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Publication number
RU2492864C2
RU2492864C2 RU2009114414/15A RU2009114414A RU2492864C2 RU 2492864 C2 RU2492864 C2 RU 2492864C2 RU 2009114414/15 A RU2009114414/15 A RU 2009114414/15A RU 2009114414 A RU2009114414 A RU 2009114414A RU 2492864 C2 RU2492864 C2 RU 2492864C2
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cancer
egfr
treatment
gefitinib
forms
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RU2009114414/15A
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English (en)
Russian (ru)
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RU2009114414A (ru
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Флавио Золька
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Бёрингер Ингельхайм Интернациональ Гмбх
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
RU2009114414/15A 2006-09-18 2007-09-14 Способ лечения рака, несущего мутации egfr RU2492864C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP06120856.7 2006-09-18
EP06120856 2006-09-18
EP07101505 2007-01-31
EP07101505.1 2007-01-31
PCT/EP2007/059735 WO2008034776A1 (en) 2006-09-18 2007-09-14 Method for treating cancer harboring egfr mutations

Publications (2)

Publication Number Publication Date
RU2009114414A RU2009114414A (ru) 2010-12-27
RU2492864C2 true RU2492864C2 (ru) 2013-09-20

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ID=38698376

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RU2009114414/15A RU2492864C2 (ru) 2006-09-18 2007-09-14 Способ лечения рака, несущего мутации egfr

Country Status (19)

Country Link
US (1) US8877764B2 (https=)
EP (1) EP2068880B1 (https=)
JP (1) JP2010503717A (https=)
KR (1) KR20090074202A (https=)
AT (1) ATE552835T1 (https=)
AU (1) AU2007299080B2 (https=)
BR (1) BRPI0717586A2 (https=)
CA (1) CA2663599A1 (https=)
CY (1) CY1112896T1 (https=)
DK (1) DK2068880T3 (https=)
ES (1) ES2385613T3 (https=)
IL (1) IL197605A0 (https=)
MX (1) MX2009002710A (https=)
NZ (1) NZ576065A (https=)
PL (1) PL2068880T3 (https=)
PT (1) PT2068880E (https=)
RU (1) RU2492864C2 (https=)
SI (1) SI2068880T1 (https=)
WO (1) WO2008034776A1 (https=)

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RU2663929C2 (ru) * 2016-12-22 2018-08-13 3СМ Биотрон Инк. Использование производного соединения тиохромено[2,3-с]хинолин-12-она для лечения немелкоклеточного рака легких
EA032217B1 (ru) * 2015-07-31 2019-04-30 Ле Лаборатуар Сервье Новое сочетание 3-[(3-{[4-(4-морфолинилметил)-1h-пиррол-2-ил]метилен}-2-оксо-2,3-дигидро-1h-индол-5-ил)метил]-1,3-тиазолидин-2,4-диона и ингибитора тирозинкиназы egfr
RU2821531C2 (ru) * 2022-06-29 2024-06-25 Акционерное общество "БИОКАД" Ингибиторы рецептора эпидермального фактора роста

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DE10349113A1 (de) * 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
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BRPI0914790A2 (pt) 2008-06-17 2015-10-20 Wyeth Llc uso de um composto de vinorelbina e um composto de hki-272, composição farmacêutica e produto e kit para o tratamento de neoplasma
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WO2012125904A1 (en) * 2011-03-17 2012-09-20 The Trustees Of The University Of Pennsylvania Mutation mimicking compounds that bind to the kinase domain of egfr
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EP2968551B1 (en) 2013-03-15 2021-05-05 The Trustees of Columbia University in the City of New York Fusion proteins and methods thereof
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CN107980041A (zh) 2015-06-12 2018-05-01 费森尤斯卡比肿瘤学有限公司 阿法替尼游离碱及其马来酸氢盐的多晶型形式
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CA3042697A1 (en) * 2016-11-03 2018-05-11 The Regents Of The University Of Michigan Small molecule dual inhibitors of egfr/pi3k and uses thereof
KR102771603B1 (ko) * 2016-11-17 2025-02-24 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 Egfr 또는 her2 엑손 20 돌연변이를 갖는 암 세포에 대한 항종양 활성을 갖는 화합물
JP7122256B2 (ja) 2017-02-14 2022-08-19 アイソフォル・メディカル・エービー 血漿２’－デオキシウリジン（ｄＵｒｄ）の増加およびチミジル酸合成酵素阻害のための方法
EP3679063A4 (en) * 2017-09-08 2021-06-02 The Regents of The University of Colorado, A Body Corporate COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATMENT OR PREVENTION OF HER-CONTROLLED DRUG-RESISTANT CANCER
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CN116850289B (zh) * 2022-07-29 2025-10-28 东北大学 Plk4靶向药物在治疗对铂类药物耐药型肿瘤中的应用

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