JP2010507367A - モナチンの立体異性体およびそれらの前駆体の生成のためのポリペプチドおよび生合成経路 - Google Patents

モナチンの立体異性体およびそれらの前駆体の生成のためのポリペプチドおよび生合成経路 Download PDF

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JP2010507367A
JP2010507367A JP2009533566A JP2009533566A JP2010507367A JP 2010507367 A JP2010507367 A JP 2010507367A JP 2009533566 A JP2009533566 A JP 2009533566A JP 2009533566 A JP2009533566 A JP 2009533566A JP 2010507367 A JP2010507367 A JP 2010507367A
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amino acid
racemase
seq
monatin
aminotransferase
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JP2010507367A5 (cg-RX-API-DMAC7.html
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ブライアン・ジェイ・ブラゾー
マービン・エル・デ・ソウザ
スティーブン・ジェイ・ゴート
ポーラ・エム・ヒックス
シェリー・アール・コールマン
ホセ・エム・ラプラザ
サラ・シー・マクファーラン
フェルナンド・エイ・サンチェズ−リーラ
クリストファー・ソルヘイド
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カーギル・インコーポレイテッド
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom

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  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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JP2009533566A 2006-10-20 2007-10-19 モナチンの立体異性体およびそれらの前駆体の生成のためのポリペプチドおよび生合成経路 Pending JP2010507367A (ja)

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US58401606A 2006-10-20 2006-10-20
US11/714,279 US8076108B2 (en) 2005-04-26 2007-03-06 Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
PCT/US2007/081932 WO2008085575A2 (en) 2006-10-20 2007-10-19 Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors

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JP2010507367A true JP2010507367A (ja) 2010-03-11
JP2010507367A5 JP2010507367A5 (cg-RX-API-DMAC7.html) 2011-01-13

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JP2015122370A Pending JP2015211679A (ja) 2006-10-20 2015-06-17 モナチンの立体異性体およびそれらの前駆体の生成のためのポリペプチドおよび生合成経路

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US (2) US8076108B2 (cg-RX-API-DMAC7.html)
EP (1) EP2089529B1 (cg-RX-API-DMAC7.html)
JP (2) JP2010507367A (cg-RX-API-DMAC7.html)
AR (1) AR063348A1 (cg-RX-API-DMAC7.html)
AU (1) AU2007342275B2 (cg-RX-API-DMAC7.html)
CA (1) CA2666348A1 (cg-RX-API-DMAC7.html)
WO (1) WO2008085575A2 (cg-RX-API-DMAC7.html)

Cited By (2)

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WO2012147674A1 (ja) * 2011-04-25 2012-11-01 味の素株式会社 モナティンの製造方法
CN106636227A (zh) * 2016-09-22 2017-05-10 精晶药业股份有限公司 一种酶法转化l‑丙氨酸制备丙酮酸的方法

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JP2007503214A (ja) * 2003-08-25 2007-02-22 カーギル，インコーポレイティド モナチンを含む飲料組成物及びその製造方法
US8206955B2 (en) * 2003-10-21 2012-06-26 Cargill, Incorporated Production of monatin and monatin precursors
CN101223444B (zh) * 2005-04-20 2013-04-24 嘉吉有限公司 在体内分泌莫纳甜的方法
US8158389B2 (en) * 2005-04-20 2012-04-17 Cargill, Incorporated Products and methods for in vivo secretion of monatin
US8076108B2 (en) 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US7582455B2 (en) * 2005-04-26 2009-09-01 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
WO2007103389A2 (en) * 2006-03-07 2007-09-13 Cargill, Incorporated Aldolases, nucleic acids encoding them and methods for making and using them
EA019971B1 (ru) * 2006-03-07 2014-07-30 Верениум Корпорейшн Альдолазы, кодирующие их нуклеиновые кислоты и способы их получения и применения
US20090198072A1 (en) * 2006-05-24 2009-08-06 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
AU2007267618B2 (en) * 2006-05-24 2013-07-18 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
CN101239941B (zh) * 2007-02-08 2012-02-29 味之素株式会社 光学活性化合物的制造方法
US8367847B2 (en) * 2007-10-01 2013-02-05 Cargill, Incorporated Production of monatin enantiomers
US8076107B2 (en) * 2007-10-01 2011-12-13 Cargill, Incorporated Production of monatin stereoisomers
US8003361B2 (en) * 2007-10-01 2011-08-23 Cargill Incorporated Production of monatin enantiomers
WO2009088482A1 (en) 2008-01-03 2009-07-16 Cargill, Incorporated Aminotransferase and oxidoreductase nucleic acids and polypeptides and methods of using
WO2009088442A2 (en) * 2008-01-03 2009-07-16 Cargill, Incorporated Isomerases and epimerases and methods of using
EP2479272A4 (en) 2010-10-14 2013-11-20 Ajinomoto Kk PROCESS FOR THE PRODUCTION OF MONATIN
US8771997B2 (en) 2011-04-20 2014-07-08 Ajinomoto Co., Inc. Method for producing monatin using an L-amino acid aminotransferase
ES2538720B1 (es) * 2013-12-20 2016-05-12 Universidad Autónoma de Madrid Racemasa BsrAh para la racemización de aminoácidos
US11685942B2 (en) 2016-03-04 2023-06-27 President And Fellows Of Harvard College Methods for making polypeptides including d-amino acids
CN113025602A (zh) * 2021-03-18 2021-06-25 绵阳晟氏健康科技有限公司 固定化精氨酸消旋酶及其制备方法、应用

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