JP2010506591A - 哺乳動物細胞中の蛋白質への非天然アミノ酸の遺伝的組込み - Google Patents
哺乳動物細胞中の蛋白質への非天然アミノ酸の遺伝的組込み Download PDFInfo
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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| PCT/US2007/022232 WO2008073184A2 (en) | 2006-10-18 | 2007-10-17 | Genetic incorporation of unnatural amino acids into proteins in mammalian cells |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015530091A (ja) * | 2012-09-24 | 2015-10-15 | メディミューン リミテッド | 細胞株 |
| JP2020522247A (ja) * | 2017-06-02 | 2020-07-30 | アンブルックス, インコーポレイテッドAmbrx, Inc. | 非天然アミノ酸含有タンパク質の産生を促進する方法および組成物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1490483B1 (en) * | 2001-04-19 | 2015-06-03 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| KR20050073559A (ko) * | 2002-10-16 | 2005-07-14 | 더 스크립스 리서치 인스티튜트 | 당단백질 합성 |
| CN103289960B (zh) | 2003-04-17 | 2017-04-26 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| DE602004011789T2 (de) * | 2003-07-07 | 2009-02-12 | The Scripps Research Institute, La Jolla | Zusammensetzungen der orthogonalen Lysyl-tRNA und Aminoacyl-tRNA Synthetase Paaren und ihre Verwendungen |
| WO2010114615A2 (en) * | 2009-04-03 | 2010-10-07 | The Scripps Research Institute | A facile system for encoding unnatural amino acids in mammalian cells |
| EP2647721B1 (en) | 2010-12-03 | 2019-02-27 | The University of Tokyo | Peptide with safer secondary structure, peptide library, and production methods for same |
| DE102010056289A1 (de) | 2010-12-24 | 2012-06-28 | Geneart Ag | Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken |
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| JP2015530091A (ja) * | 2012-09-24 | 2015-10-15 | メディミューン リミテッド | 細胞株 |
| JP2020522247A (ja) * | 2017-06-02 | 2020-07-30 | アンブルックス, インコーポレイテッドAmbrx, Inc. | 非天然アミノ酸含有タンパク質の産生を促進する方法および組成物 |
| JP7245786B2 (ja) | 2017-06-02 | 2023-03-24 | アンブルックス，インコーポレイテッド | 非天然アミノ酸含有タンパク質の産生を促進する方法および組成物 |
| JP2023075254A (ja) * | 2017-06-02 | 2023-05-30 | アンブルックス，インコーポレイテッド | 非天然アミノ酸含有タンパク質の産生を促進する方法および組成物 |
| US11851662B2 (en) | 2017-06-02 | 2023-12-26 | Ambrx, Inc. | Methods and compositions for promoting non-natural amino acid-containing protein production |
| JP7617162B2 (ja) | 2017-06-02 | 2025-01-17 | アンブルックス，インコーポレイテッド | 非天然アミノ酸含有タンパク質の産生を促進する方法および組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20080166766A1 (en) | 2008-07-10 |
| US9624485B2 (en) | 2017-04-18 |
| RU2009112104A (ru) | 2010-11-27 |
| MX2009004043A (es) | 2009-04-27 |
| WO2008073184A2 (en) | 2008-06-19 |
| EP2069481A4 (en) | 2010-01-06 |
| BRPI0718389A2 (pt) | 2012-04-10 |
| KR20090094812A (ko) | 2009-09-08 |
| WO2008073184A3 (en) | 2008-11-27 |
| IL197917A0 (en) | 2011-08-01 |
| US20100021963A1 (en) | 2010-01-28 |
| AU2007333010A1 (en) | 2008-06-19 |
| CA2665678A1 (en) | 2008-06-19 |
| EP2069481A2 (en) | 2009-06-17 |
| CN101535338A (zh) | 2009-09-16 |
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