JP2010506591A - 哺乳動物細胞中の蛋白質への非天然アミノ酸の遺伝的組込み - Google Patents
哺乳動物細胞中の蛋白質への非天然アミノ酸の遺伝的組込み Download PDFInfo
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015530091A (ja) * | 2012-09-24 | 2015-10-15 | メディミューン リミテッド | 細胞株 |
| JP2020522247A (ja) * | 2017-06-02 | 2020-07-30 | アンブルックス, インコーポレイテッドAmbrx, Inc. | 非天然アミノ酸含有タンパク質の産生を促進する方法および組成物 |
| US12565646B2 (en) | 2019-06-21 | 2026-03-03 | Trustees Of Boston College | Enhanced platforms for unnatural amino acid incorporation in mammalian cells |
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| ES2464532T3 (es) * | 2001-04-19 | 2014-06-03 | The Scripps Research Institute | Métodos y composiciones para la producción de pares ortogonales de ARNt-aminoacil-ARNt sintetasa |
| EP1558747B1 (en) * | 2002-10-16 | 2009-10-14 | The Scripps Research Institute | Glycoprotein synthesis |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| WO2010114615A2 (en) * | 2009-04-03 | 2010-10-07 | The Scripps Research Institute | A facile system for encoding unnatural amino acids in mammalian cells |
| EP2647721B1 (en) * | 2010-12-03 | 2019-02-27 | The University of Tokyo | Peptide with safer secondary structure, peptide library, and production methods for same |
| DE102010056289A1 (de) | 2010-12-24 | 2012-06-28 | Geneart Ag | Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken |
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| JP2015530091A (ja) * | 2012-09-24 | 2015-10-15 | メディミューン リミテッド | 細胞株 |
| JP2020522247A (ja) * | 2017-06-02 | 2020-07-30 | アンブルックス, インコーポレイテッドAmbrx, Inc. | 非天然アミノ酸含有タンパク質の産生を促進する方法および組成物 |
| JP7245786B2 (ja) | 2017-06-02 | 2023-03-24 | アンブルックス，インコーポレイテッド | 非天然アミノ酸含有タンパク質の産生を促進する方法および組成物 |
| JP2023075254A (ja) * | 2017-06-02 | 2023-05-30 | アンブルックス，インコーポレイテッド | 非天然アミノ酸含有タンパク質の産生を促進する方法および組成物 |
| US11851662B2 (en) | 2017-06-02 | 2023-12-26 | Ambrx, Inc. | Methods and compositions for promoting non-natural amino acid-containing protein production |
| JP7617162B2 (ja) | 2017-06-02 | 2025-01-17 | アンブルックス，インコーポレイテッド | 非天然アミノ酸含有タンパク質の産生を促進する方法および組成物 |
| JP2025061014A (ja) * | 2017-06-02 | 2025-04-10 | アンブルックス，インコーポレイテッド | 非天然アミノ酸含有タンパク質の産生を促進する方法および組成物 |
| US12577575B2 (en) | 2017-06-02 | 2026-03-17 | Ambrx, Inc. | Methods and compositions for promoting non-natural amino acid-containing protein production |
| US12565646B2 (en) | 2019-06-21 | 2026-03-03 | Trustees Of Boston College | Enhanced platforms for unnatural amino acid incorporation in mammalian cells |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2069481A2 (en) | 2009-06-17 |
| RU2009112104A (ru) | 2010-11-27 |
| EP2069481A4 (en) | 2010-01-06 |
| WO2008073184A3 (en) | 2008-11-27 |
| CN101535338A (zh) | 2009-09-16 |
| BRPI0718389A2 (pt) | 2012-04-10 |
| WO2008073184A2 (en) | 2008-06-19 |
| KR20090094812A (ko) | 2009-09-08 |
| US20080166766A1 (en) | 2008-07-10 |
| US9624485B2 (en) | 2017-04-18 |
| US20100021963A1 (en) | 2010-01-28 |
| CA2665678A1 (en) | 2008-06-19 |
| MX2009004043A (es) | 2009-04-27 |
| IL197917A0 (en) | 2011-08-01 |
| AU2007333010A1 (en) | 2008-06-19 |
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