JP2010077137A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010077137A5 JP2010077137A5 JP2009256358A JP2009256358A JP2010077137A5 JP 2010077137 A5 JP2010077137 A5 JP 2010077137A5 JP 2009256358 A JP2009256358 A JP 2009256358A JP 2009256358 A JP2009256358 A JP 2009256358A JP 2010077137 A5 JP2010077137 A5 JP 2010077137A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- ring
- alkyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000006413 ring segment Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000004419 alkynylene group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000004474 heteroalkylene group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- SFJFBTPHDHUUPU-HNNXBMFYSA-N (5r)-5-[[4-(5-chloropyridin-2-yl)oxypiperidin-1-yl]sulfonylmethyl]-5-methylimidazolidine-2,4-dione Chemical compound C1CC(OC=2N=CC(Cl)=CC=2)CCN1S(=O)(=O)C[C@]1(C)NC(=O)NC1=O SFJFBTPHDHUUPU-HNNXBMFYSA-N 0.000 claims 1
- SFJFBTPHDHUUPU-OAHLLOKOSA-N (5s)-5-[[4-(5-chloropyridin-2-yl)oxypiperidin-1-yl]sulfonylmethyl]-5-methylimidazolidine-2,4-dione Chemical compound C1CC(OC=2N=CC(Cl)=CC=2)CCN1S(=O)(=O)C[C@@]1(C)NC(=O)NC1=O SFJFBTPHDHUUPU-OAHLLOKOSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0100902A SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Compounds |
| SE0100902-6 | 2001-03-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002573776A Division JP2004527515A (ja) | 2001-03-15 | 2002-03-13 | メタロプロテイナーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010077137A JP2010077137A (ja) | 2010-04-08 |
| JP2010077137A5 true JP2010077137A5 (enExample) | 2010-07-01 |
| JP5140058B2 JP5140058B2 (ja) | 2013-02-06 |
Family
ID=20283374
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002573760A Expired - Fee Related JP4390457B2 (ja) | 2001-03-15 | 2002-03-13 | メタロプロテイナーゼ阻害剤 |
| JP2002573757A Pending JP2004523581A (ja) | 2001-03-15 | 2002-03-13 | メタロプロテイナーゼ阻害剤 |
| JP2002573776A Withdrawn JP2004527515A (ja) | 2001-03-15 | 2002-03-13 | メタロプロテイナーゼ阻害剤 |
| JP2009256358A Expired - Fee Related JP5140058B2 (ja) | 2001-03-15 | 2009-11-09 | メタロプロテイナーゼ阻害剤 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002573760A Expired - Fee Related JP4390457B2 (ja) | 2001-03-15 | 2002-03-13 | メタロプロテイナーゼ阻害剤 |
| JP2002573757A Pending JP2004523581A (ja) | 2001-03-15 | 2002-03-13 | メタロプロテイナーゼ阻害剤 |
| JP2002573776A Withdrawn JP2004527515A (ja) | 2001-03-15 | 2002-03-13 | メタロプロテイナーゼ阻害剤 |
Country Status (32)
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0100903D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| EP1397137B1 (en) | 2001-05-25 | 2009-10-14 | Bristol-Myers Squibb Company | Hydantion derivatives as inhibitors of matrix metalloproteinases |
| SE0103710D0 (sv) | 2001-11-07 | 2001-11-07 | Astrazeneca Ab | Compounds |
| DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
| SE0202539D0 (sv) | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
| SE0202693D0 (sv) * | 2002-09-11 | 2002-09-11 | Astrazeneca Ab | Compounds |
| GB0221246D0 (en) * | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
| AU2003282920A1 (en) * | 2002-10-04 | 2004-05-04 | Bristol-Myers Squibb Company | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace) |
| WO2005016910A1 (ja) | 2003-08-18 | 2005-02-24 | Sankio Chemical Co., Ltd. | ピリジルテトラヒドロピリジン類およびピリジルピペリジン類とそれらの製造方法 |
| WO2005090316A1 (en) * | 2004-03-12 | 2005-09-29 | Wyeth | HYDANTOINS HAVING RNase MODULATORY ACTIVITY |
| SE0401763D0 (sv) * | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Compounds |
| SE0401762D0 (sv) * | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
| US7648992B2 (en) | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
| WO2006029173A2 (en) * | 2004-09-08 | 2006-03-16 | Boys Town National Research Hospital | Treatment of glomerular basement membrane disease involving matrix metalloproteinase-12 |
| CA2580855A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| BRPI0515482A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
| WO2006034341A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| AR051026A1 (es) * | 2004-09-20 | 2006-12-13 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| MX2007003327A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
| US8071603B2 (en) | 2004-09-20 | 2011-12-06 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| TW200626138A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| GB0427403D0 (en) * | 2004-12-15 | 2005-01-19 | Astrazeneca Ab | Novel compounds I |
| SE0403086D0 (sv) * | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
| SE0403085D0 (sv) * | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
| WO2006099598A2 (en) * | 2005-03-16 | 2006-09-21 | Sensus Metering Systems Inc. | Determining a physical location of a sensor |
| US8541457B2 (en) | 2005-06-03 | 2013-09-24 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors |
| WO2007078335A2 (en) * | 2005-12-21 | 2007-07-12 | Decode Genetics, Ehf. | Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation |
| PE20071241A1 (es) | 2006-01-17 | 2008-01-14 | Schering Corp | Compuestos derivados de hidantoina para el tratamiento de trastornos inflamatorios |
| TW200740769A (en) * | 2006-03-16 | 2007-11-01 | Astrazeneca Ab | Novel process |
| TW200800954A (en) * | 2006-03-16 | 2008-01-01 | Astrazeneca Ab | Novel crystal modifications |
| MX2008013624A (es) * | 2006-05-12 | 2008-10-30 | Sca Hygiene Prod Ab | Laminado elastico y un metodo para producir un laminado elastico. |
| US8852372B2 (en) * | 2006-05-12 | 2014-10-07 | Sca Hygiene Products Ab | Pant-type absorbent article and a method for producing pant-type absorbent articles |
| WO2008053199A1 (en) * | 2006-10-30 | 2008-05-08 | Astrazeneca Ab | Combination therapy for the treatment of respiratory diseases |
| TW200831488A (en) * | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
| GB0702456D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | New combination |
| WO2009007747A2 (en) * | 2007-07-11 | 2009-01-15 | Astrazeneca Ab | Hydantoin derivatives used as mmp12 inhibitors |
| BRPI0722260A2 (pt) | 2007-11-14 | 2014-04-01 | Sca Hygiene Prod Ab | Método de produção de um vestuário absorvente, e um vestuário absorvente produzido de acordo com o método |
| WO2009064225A1 (en) | 2007-11-14 | 2009-05-22 | Sca Hygiene Products Ab | Method of producing an absorbent garment, and an absorbent garment produced according to the method |
| FR2927330B1 (fr) * | 2008-02-07 | 2010-02-19 | Sanofi Aventis | Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antagonistes des recepteurs a l'urotensine ii |
| JP5539965B2 (ja) | 2008-04-28 | 2014-07-02 | レバレジオ コーポレイション | 多発性硬化症を治療するための組成物および方法 |
| FR2944524B1 (fr) | 2009-04-17 | 2012-11-30 | Ipsen Pharma Sas | Derives d'imidazolidine-2,4-dione et leur utilisation comme medicament |
| PT2433940E (pt) * | 2009-04-28 | 2014-12-12 | Chugai Pharmaceutical Co Ltd | Derivado de espiroimidazolona |
| GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| WO2011054734A1 (de) * | 2009-11-06 | 2011-05-12 | Basf Se | Eisen- und manganhaltiger heterogenkatalysator und verfahren zur herstellung von olefinen durch umsetzung von kohlenmonoxid mit wasserstoff |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| WO2011073662A1 (en) | 2009-12-17 | 2011-06-23 | Astrazeneca Ab | Combination of a benzoxazinone and a further agent for treating respiratory diseases |
| US20110202284A1 (en) * | 2010-02-10 | 2011-08-18 | Mcreynolds Cristopher | Novel groups of biomarkers for diagnosing alzheimer's disease |
| RU2441069C2 (ru) * | 2010-03-11 | 2012-01-27 | Галина Ивановна Эль-Регистан | Стабилизатор ферментных белков |
| RU2441068C2 (ru) * | 2010-03-11 | 2012-01-27 | Галина Ивановна Эль-Регистан | Способ направленного изменения активности ферментных белков |
| RU2430371C1 (ru) * | 2010-04-26 | 2011-09-27 | Учреждение Российской академии наук Институт ядерной физики им. Г.И. Будкера Сибирского отделения РАН (ИЯФ СО РАН) | Способ дифференциальной диагностики и прогноза миомы и рака эндометрия |
| EP2575815A4 (en) | 2010-06-04 | 2013-12-25 | Albany Molecular Res Inc | GLYCIN TRANSPORTER 1 INHIBITORS, METHODS OF MAKING THE SAME, AND USES THEREOF |
| GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
| GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
| JP6262733B2 (ja) * | 2012-09-04 | 2018-01-17 | シャンハイ ヘンルイ ファーマスーティカル カンパニー リミテッドＳｈａｎｇｈａｉ Ｈｅｎｇｒｕｉ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． | イミダゾリン誘導体、その製造法、およびそれらの医薬への適用 |
| SI2930176T1 (en) | 2012-12-10 | 2018-06-29 | Chugai Seiyaku Kabushiki Kaisha | HIDANTOIN DERIVATIVES |
| HUE050907T2 (hu) * | 2013-11-13 | 2021-01-28 | Hankkija Oy | Gyantasavakat tartalmazó takarmány-kiegészítõ |
| US9676752B2 (en) * | 2013-12-31 | 2017-06-13 | Ipsen Pharma S.A.S. | Imidazolidine-2,4-dione derivatives |
| EP2907512A1 (en) | 2014-02-14 | 2015-08-19 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Inhibitors of MMP-12 as antiviral Agents |
| CN106572994B (zh) | 2014-06-09 | 2020-09-18 | 中外制药株式会社 | 含有乙内酰脲衍生物的药物组合物 |
| US9556146B2 (en) | 2014-10-24 | 2017-01-31 | Biotherapeutics, Inc. | Lanthionine synthetase C-like 2-based therapeutics |
| JO3501B1 (ar) * | 2014-12-22 | 2020-07-05 | Servier Lab | مشتقات 5-{(بيبرازين - 1-يل)-3-أوكسو - بروبيل}- إيميدازوليدين-2، 4 - دايون كمثبطات ل adamts لمعالجة هشاشة العظام) |
| US10640484B2 (en) * | 2016-09-23 | 2020-05-05 | Kaken Pharmaceutical Co., Ltd. | Method for producing (R)-5-(3,4-difluorophenyl)-5-[(3-methyl-2-oxopyridin-1(2H)-yl)methyl]imidazolidine-2,4-dione and intermediate for producing same |
| WO2021011720A2 (en) * | 2019-07-18 | 2021-01-21 | Avidence Therapeutics, Inc. | Anti-osteoarthritis compounds and related compositions and methods |
| PT4058437T (pt) * | 2019-11-14 | 2025-02-10 | Foresee Pharmaceuticals Usa Inc | Inibidores de metaloproteinases de matriz (mmp) e métodos de uso dos mesmos |
| WO2021127472A1 (en) | 2019-12-20 | 2021-06-24 | Landos Biopharma, Inc. | Lanthionine c-like protein 2 ligands, cells prepared therewith, and therapies using same |
| US12234578B2 (en) | 2020-01-29 | 2025-02-25 | Wisconsin Alumni Research Foundation | Tannin composite fibers |
| WO2021260387A1 (en) | 2020-06-26 | 2021-12-30 | The University Of Birmingham | Mmp-9 and mmp-12 inhibition for treating spinal cord injury or related injury to neurological tissue |
| CN115720578B (zh) * | 2020-07-09 | 2025-06-13 | 深圳信立泰药业股份有限公司 | 并三环类衍生物、其制备方法及其在医药上的应用 |
| CN112574193B (zh) * | 2020-12-31 | 2022-05-17 | 南京医科大学 | 一类口服gsnor抑制剂及其药物用途 |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2327890A (en) * | 1940-04-17 | 1943-08-24 | Parke Davis & Co | Substituted phenoxyalkyl ethers |
| US2745875A (en) * | 1953-06-30 | 1956-05-15 | Hoechst Ag | Preparation of nu-acylamino-phenylpropane diols |
| US3452040A (en) * | 1966-01-05 | 1969-06-24 | American Home Prod | 5,5-disubstituted hydantoins |
| US3529019A (en) * | 1968-04-23 | 1970-09-15 | Colgate Palmolive Co | Alkylaryloxy alanines |
| CS152617B1 (enExample) | 1970-12-29 | 1974-02-22 | ||
| CS151744B1 (enExample) * | 1971-01-19 | 1973-11-19 | ||
| US3849574A (en) * | 1971-05-24 | 1974-11-19 | Colgate Palmolive Co | Alpha-substituted-beta-arylthioalkyl amino-acids,for increasing heart rate |
| US4315031A (en) * | 1977-09-01 | 1982-02-09 | Science Union Et Cie | Thiosubstituted amino acids |
| GB1601310A (en) * | 1978-05-23 | 1981-10-28 | Lilly Industries Ltd | Aryl hydantoins |
| JPS6172762A (ja) | 1984-09-17 | 1986-04-14 | Kanegafuchi Chem Ind Co Ltd | 光学活性ヒダントイン類の製造法 |
| JPS61212292A (ja) * | 1985-03-19 | 1986-09-20 | Mitsui Toatsu Chem Inc | Ｄ−α−アミノ酸の製造方法 |
| CA1325222C (en) | 1985-08-23 | 1993-12-14 | Lederle (Japan), Ltd. | Process for producing 4-biphenylylacetic acid |
| GB8618559D0 (en) | 1986-07-30 | 1986-09-10 | Genetics Int Inc | Rhodococcus bacterium |
| JPH0279879A (ja) | 1988-09-17 | 1990-03-20 | Canon Inc | 画像形成装置 |
| US4983771A (en) | 1989-09-18 | 1991-01-08 | Hexcel Corporation | Method for resolution of D,L-alpha-phenethylamine with D(-)mandelic acid |
| NL9000386A (nl) | 1990-02-16 | 1991-09-16 | Stamicarbon | Werkwijze voor de bereiding van optisch aktief aminozuuramide. |
| DK161690D0 (da) | 1990-07-05 | 1990-07-05 | Novo Nordisk As | Fremgangsmaade til fremstilling af enantiomere forbindelser |
| IL99957A0 (en) | 1990-11-13 | 1992-08-18 | Merck & Co Inc | Piperidinylcamphorsulfonyl oxytocin antagonists and pharmaceutical compositions containing them |
| PH31245A (en) * | 1991-10-30 | 1998-06-18 | Janssen Pharmaceutica Nv | 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives. |
| US5308853A (en) * | 1991-12-20 | 1994-05-03 | Warner-Lambert Company | Substituted-5-methylidene hydantoins with AT1 receptor antagonist properties |
| US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| NL9201230A (nl) | 1992-07-09 | 1994-02-01 | Dsm Nv | Werkwijze voor de bereiding van optisch aktief methionineamide. |
| EP0640594A1 (en) | 1993-08-23 | 1995-03-01 | Fujirebio Inc. | Hydantoin derivative as metalloprotease inhibitor |
| JPH07105549A (ja) | 1993-09-30 | 1995-04-21 | Canon Inc | 光学的情報記録再生方法及び光学的情報記録再生装置 |
| AU687953B2 (en) | 1993-11-16 | 1998-03-05 | Merck & Co., Inc. | Piperidinylcamphorsulfonyl oxytocin antagonists |
| WO1995020587A1 (en) | 1994-01-31 | 1995-08-03 | Pfizer Inc. | Neuroprotective chroman compounds |
| EP0709375B1 (en) | 1994-10-25 | 2005-05-18 | AstraZeneca AB | Therapeutic heterocycles |
| ZA96211B (en) | 1995-01-12 | 1996-07-26 | Teva Pharma | Compositions containing and methods of using 1- aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
| US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
| US6166041A (en) * | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
| DE19540027A1 (de) * | 1995-10-27 | 1997-04-30 | Gruenenthal Gmbh | Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe |
| JP2000500482A (ja) * | 1995-11-22 | 2000-01-18 | ダーウィン・ディスカバリー・リミテッド | イミダゾール置換基を有するメルカプトアルキルペプチジル化合物並びにマトリックス金属プロテイナーゼ（ｍｍｐ）および／または腫瘍壊死因子（ｔｎｆ）のインヒビターとしての該化合物の使用 |
| GB9616643D0 (en) * | 1996-08-08 | 1996-09-25 | Chiroscience Ltd | Compounds |
| US5919790A (en) * | 1996-10-11 | 1999-07-06 | Warner-Lambert Company | Hydroxamate inhibitors of interleukin-1β converting enzyme |
| US5804593A (en) * | 1996-10-22 | 1998-09-08 | Pharmacia & Upjohn Company | α-Amino sulfonyl hydroxamic acids as matrix metalloproteinase inhibitors |
| HUP0003362A3 (en) | 1997-05-06 | 2001-04-28 | Novo Nordisk As | Piperidine derivatives and pharmaceutical compositions containing them |
| DE59802394D1 (de) * | 1997-05-09 | 2002-01-24 | Hoechst Ag | Substituierte Diaminocarbonsäuren |
| ES2247707T3 (es) | 1997-06-21 | 2006-03-01 | Roche Diagnostics Gmbh | Derivados del acido barbiturico con actividad antimetastasica y antitumoral. |
| DE19726427A1 (de) | 1997-06-23 | 1998-12-24 | Boehringer Mannheim Gmbh | Pyrimidin-2,4,6-trion-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| NZ501166A (en) * | 1997-07-31 | 2001-12-21 | Abbott Lab | Reverse hydroxamate-containing compounds and their use as inhibitors of matrix metalloproteinases |
| TW514634B (en) | 1997-10-14 | 2002-12-21 | Lilly Co Eli | Process to make chiral compounds |
| IL135921A (en) * | 1997-11-12 | 2005-08-31 | Darwin Discovery Ltd | Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity |
| JP4750272B2 (ja) * | 1998-02-04 | 2011-08-17 | ノバルティス アーゲー | マトリックス分解メタロプロテイナーゼを阻害するスルホニルアミノ誘導体 |
| US6329418B1 (en) * | 1998-04-14 | 2001-12-11 | The Procter & Gamble Company | Substituted pyrrolidine hydroxamate metalloprotease inhibitors |
| AU4074799A (en) * | 1998-05-14 | 1999-11-29 | Du Pont Pharmaceuticals Company | Substituted aryl hydroxamic acids as metalloproteinase inhibitors |
| AU1708099A (en) * | 1998-06-03 | 1999-12-20 | Amgen, Inc. | N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres |
| CA2333554A1 (en) * | 1998-06-17 | 1999-12-23 | Chu-Baio Xue | Cyclic hydroxamic acids as metalloproteinase inhibitors |
| FR2782082B3 (fr) | 1998-08-05 | 2000-09-22 | Sanofi Sa | Formes cristallines de (r)-(+)-n-[[3-[1-benzoyl-3-(3,4- dichlorophenyl)piperidin-3-yl]prop-1-yl]-4-phenylpiperidin-4 -yl]-n-methylacetamide (osanetant) et procede pour la preparation dudit compose |
| US6339101B1 (en) * | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
| JP2000127349A (ja) * | 1998-08-21 | 2000-05-09 | Komori Corp | 凹版印刷機 |
| JP2002523492A (ja) | 1998-08-29 | 2002-07-30 | ブリティッシュ バイオテック ファーマシューティカルズ リミテッド | タンパク質分解酵素阻害剤としてのヒドロキサム酸誘導体 |
| GB9919776D0 (en) | 1998-08-31 | 1999-10-27 | Zeneca Ltd | Compoujnds |
| JP2002526370A (ja) | 1998-10-07 | 2002-08-20 | 矢崎総業株式会社 | 多孔質型を用いたゾル・ゲル法 |
| ES2213985T3 (es) * | 1998-11-05 | 2004-09-01 | Pfizer Products Inc. | Derivados de hidroxiamida de acido 5-oxo-pirrolidin-2-carboxilico. |
| JP2002532479A (ja) | 1998-12-18 | 2002-10-02 | アクシス・ファーマシューティカルズ・インコーポレイテッド | プロテアーゼインヒビター |
| EP1150975A1 (en) * | 1998-12-31 | 2001-11-07 | Aventis Pharmaceuticals Inc. | 1-carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of mmp-12 |
| US6340691B1 (en) * | 1999-01-27 | 2002-01-22 | American Cyanamid Company | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors |
| EP1149843A4 (en) | 1999-01-28 | 2012-06-06 | Chugai Pharmaceutical Co Ltd | SUBSTITUTED PHENETHYLAMINE DERIVATIVES |
| US6294694B1 (en) | 1999-06-04 | 2001-09-25 | Wisconsin Alumni Research Foundation | Matrix metalloproteinase inhibitors and method of using same |
| GB9916562D0 (en) * | 1999-07-14 | 1999-09-15 | Pharmacia & Upjohn Spa | 3-Arylsulfonyl-2-(substituted-methyl) propanoic acid derivatives as matrix metalloproteinase inhibitora |
| US20020006920A1 (en) | 1999-07-22 | 2002-01-17 | Robinson Ralph Pelton | Arylsulfonylamino hydroxamic acid derivatives |
| US6266453B1 (en) | 1999-07-26 | 2001-07-24 | Computerized Medical Systems, Inc. | Automated image fusion/alignment system and method |
| PT1078923E (pt) * | 1999-08-02 | 2006-07-31 | Hoffmann La Roche | Processo para a preparacao de derivados de benzotiofeno |
| GEP20053476B (en) | 1999-08-12 | 2005-03-25 | Upjohn Co | 3(5)-Amino-Pyrazole Derivatives, Process for Their Preparation and Their Use as Antitumor Agents |
| JP3710964B2 (ja) | 1999-08-26 | 2005-10-26 | 富士通株式会社 | ディスプレイデバイスのレイアウト設計方法 |
| SE9904044D0 (sv) | 1999-11-09 | 1999-11-09 | Astra Ab | Compounds |
| US6525202B2 (en) * | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
| CA2419008A1 (en) | 2000-08-11 | 2003-02-11 | Kaken Pharmaceutical Co., Ltd. | 2,3-diphenylpropionic acid derivatives or their salts, medicines or cell adhesion inhibitors containing the same, and their usage |
| US20020065219A1 (en) * | 2000-08-15 | 2002-05-30 | Naidu B. Narasimhulu | Water soluble thiazolyl peptide derivatives |
| WO2002020515A1 (en) | 2000-09-08 | 2002-03-14 | Abbott Laboratories | Oxazolidinone antibacterial agents |
| US20020091107A1 (en) * | 2000-09-08 | 2002-07-11 | Madar David J. | Oxazolidinone antibacterial agents |
| EP1191024A1 (en) | 2000-09-22 | 2002-03-27 | Harald Tschesche | Thiadiazines and their use as inhibitors of metalloproteinases |
| SE0100903D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| KR20030082990A (ko) | 2001-03-15 | 2003-10-23 | 아스트라제네카 아베 | 메탈로프로테이나제 억제제 |
| EP1397137B1 (en) | 2001-05-25 | 2009-10-14 | Bristol-Myers Squibb Company | Hydantion derivatives as inhibitors of matrix metalloproteinases |
| GB0114004D0 (en) | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
| SE0103710D0 (sv) * | 2001-11-07 | 2001-11-07 | Astrazeneca Ab | Compounds |
| CA2486350A1 (en) | 2002-06-05 | 2003-12-24 | Kaneka Corporation | Process for producing optically active .alpha.-methylcysteine derivative |
| SE0202539D0 (sv) * | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
| SE0202693D0 (sv) | 2002-09-11 | 2002-09-11 | Astrazeneca Ab | Compounds |
| SE0202692D0 (sv) | 2002-09-11 | 2002-09-11 | Astrazeneca Ab | Compounds |
| GB0221246D0 (en) * | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
| GB0221250D0 (en) | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
| US6890913B2 (en) * | 2003-02-26 | 2005-05-10 | Food Industry Research And Development Institute | Chitosans |
| US20040266832A1 (en) | 2003-06-26 | 2004-12-30 | Li Zheng J. | Crystal forms of 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl pyridine |
| TWI220073B (en) * | 2003-07-24 | 2004-08-01 | Au Optronics Corp | Method for manufacturing polysilicon film |
| SE0401763D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Compounds |
| SE0401762D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
| US7648992B2 (en) | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
| SE0403085D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
| SE0403086D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
| TW200800954A (en) | 2006-03-16 | 2008-01-01 | Astrazeneca Ab | Novel crystal modifications |
| TW200740769A (en) | 2006-03-16 | 2007-11-01 | Astrazeneca Ab | Novel process |
| TW200831488A (en) | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
-
2001
- 2001-03-15 SE SE0100902A patent/SE0100902D0/xx unknown
-
2002
- 2002-03-13 KR KR10-2003-7011981A patent/KR20030082986A/ko not_active Withdrawn
- 2002-03-13 CZ CZ20032499A patent/CZ20032499A3/cs unknown
- 2002-03-13 JP JP2002573760A patent/JP4390457B2/ja not_active Expired - Fee Related
- 2002-03-13 ES ES02704031T patent/ES2267986T3/es not_active Expired - Lifetime
- 2002-03-13 NZ NZ528140A patent/NZ528140A/en not_active IP Right Cessation
- 2002-03-13 SK SK1096-2003A patent/SK287766B6/sk not_active IP Right Cessation
- 2002-03-13 UA UA2003098171A patent/UA78502C2/uk unknown
- 2002-03-13 MX MXPA03008191A patent/MXPA03008191A/es active IP Right Grant
- 2002-03-13 UA UA2003098168A patent/UA77408C2/uk unknown
- 2002-03-13 WO PCT/SE2002/000472 patent/WO2002074767A1/en not_active Ceased
- 2002-03-13 IL IL15765202A patent/IL157652A0/xx unknown
- 2002-03-13 AT AT02704037T patent/ATE484496T1/de not_active IP Right Cessation
- 2002-03-13 US US10/471,810 patent/US7368465B2/en not_active Expired - Fee Related
- 2002-03-13 KR KR1020087017665A patent/KR100879905B1/ko not_active Expired - Fee Related
- 2002-03-13 CN CNB02809915XA patent/CN100526307C/zh not_active Expired - Fee Related
- 2002-03-13 EE EEP200300445A patent/EE05431B1/xx not_active IP Right Cessation
- 2002-03-13 EP EP02704037A patent/EP1370537B1/en not_active Expired - Lifetime
- 2002-03-13 IL IL15765602A patent/IL157656A0/xx unknown
- 2002-03-13 IL IL15765702A patent/IL157657A0/xx unknown
- 2002-03-13 SI SI200230386T patent/SI1370556T1/sl unknown
- 2002-03-13 ES ES06008158T patent/ES2357138T3/es not_active Expired - Lifetime
- 2002-03-13 SK SK1095-2003A patent/SK10952003A3/sk not_active Application Discontinuation
- 2002-03-13 WO PCT/SE2002/000478 patent/WO2002074751A1/en not_active Ceased
- 2002-03-13 BR BR0207984-4A patent/BR0207984A/pt not_active IP Right Cessation
- 2002-03-13 HU HU0400327A patent/HUP0400327A3/hu unknown
- 2002-03-13 RU RU2003127733/04A patent/RU2285695C2/ru not_active IP Right Cessation
- 2002-03-13 JP JP2002573757A patent/JP2004523581A/ja active Pending
- 2002-03-13 PT PT02704031T patent/PT1370556E/pt unknown
- 2002-03-13 HU HU0400194A patent/HUP0400194A3/hu unknown
- 2002-03-13 DE DE60213216T patent/DE60213216T2/de not_active Expired - Lifetime
- 2002-03-13 EE EEP200300451A patent/EE05364B1/xx not_active IP Right Cessation
- 2002-03-13 CA CA2440630A patent/CA2440630C/en not_active Expired - Fee Related
- 2002-03-13 CA CA002440631A patent/CA2440631A1/en not_active Abandoned
- 2002-03-13 KR KR1020037011987A patent/KR100886315B1/ko not_active Expired - Fee Related
- 2002-03-13 CZ CZ20032500A patent/CZ20032500A3/cs unknown
- 2002-03-13 SK SK1092-2003A patent/SK287834B6/sk not_active IP Right Cessation
- 2002-03-13 CZ CZ20032497A patent/CZ20032497A3/cs unknown
- 2002-03-13 NZ NZ528107A patent/NZ528107A/en unknown
- 2002-03-13 EP EP06008158A patent/EP1676846B1/en not_active Expired - Lifetime
- 2002-03-13 CN CNA200910147512XA patent/CN101602731A/zh active Pending
- 2002-03-13 MX MXPA03008181A patent/MXPA03008181A/es unknown
- 2002-03-13 AU AU2002237626A patent/AU2002237626B2/en not_active Ceased
- 2002-03-13 AU AU2002237632A patent/AU2002237632B2/en not_active Ceased
- 2002-03-13 DE DE60237965T patent/DE60237965D1/de not_active Expired - Lifetime
- 2002-03-13 MY MYPI20020904A patent/MY136141A/en unknown
- 2002-03-13 EE EEP200300449A patent/EE200300449A/xx unknown
- 2002-03-13 MY MYPI20020910A patent/MY136789A/en unknown
- 2002-03-13 CN CN2006101061525A patent/CN1962641B/zh not_active Expired - Fee Related
- 2002-03-13 BR BR0207983-6A patent/BR0207983A/pt not_active IP Right Cessation
- 2002-03-13 RU RU2003127734/04A patent/RU2288228C2/ru not_active IP Right Cessation
- 2002-03-13 CN CNB02810093XA patent/CN1269804C/zh not_active Expired - Fee Related
- 2002-03-13 PL PL02364707A patent/PL364707A1/xx not_active Application Discontinuation
- 2002-03-13 MX MXPA03008177A patent/MXPA03008177A/es active IP Right Grant
- 2002-03-13 ES ES02704037T patent/ES2352246T3/es not_active Expired - Lifetime
- 2002-03-13 US US10/471,900 patent/US7427631B2/en not_active Expired - Fee Related
- 2002-03-13 PL PL364706A patent/PL205315B1/pl not_active IP Right Cessation
- 2002-03-13 UA UA2003098170A patent/UA77667C2/uk unknown
- 2002-03-13 PL PL02365099A patent/PL365099A1/xx unknown
- 2002-03-13 JP JP2002573776A patent/JP2004527515A/ja not_active Withdrawn
- 2002-03-13 CN CNB028097882A patent/CN1304377C/zh not_active Expired - Fee Related
- 2002-03-13 WO PCT/SE2002/000473 patent/WO2002074748A1/en not_active Ceased
- 2002-03-13 CA CA2440473A patent/CA2440473C/en not_active Expired - Fee Related
- 2002-03-13 EP EP02704031A patent/EP1370556B1/en not_active Expired - Lifetime
- 2002-03-13 US US10/471,500 patent/US20040106659A1/en not_active Abandoned
- 2002-03-13 AT AT02704031T patent/ATE333454T1/de active
- 2002-03-13 BR BR0208104-0A patent/BR0208104A/pt not_active IP Right Cessation
- 2002-03-13 EP EP02704032A patent/EP1370534A1/en not_active Withdrawn
- 2002-03-13 DE DE60238794T patent/DE60238794D1/de not_active Expired - Lifetime
- 2002-03-13 DK DK02704031T patent/DK1370556T3/da active
- 2002-03-13 RU RU2003127735/04A patent/RU2293729C2/ru not_active IP Right Cessation
- 2002-03-13 NZ NZ528106A patent/NZ528106A/en not_active IP Right Cessation
- 2002-03-13 AT AT06008158T patent/ATE493406T1/de not_active IP Right Cessation
- 2002-03-13 KR KR10-2003-7011982A patent/KR20030082987A/ko not_active Withdrawn
- 2002-03-13 HU HU0400202A patent/HUP0400202A3/hu unknown
- 2002-03-15 AR ARP020100944A patent/AR035443A1/es active IP Right Grant
- 2002-03-15 AR ARP020100943A patent/AR035695A1/es unknown
-
2003
- 2003-08-28 IL IL157656A patent/IL157656A/en not_active IP Right Cessation
- 2003-08-28 ZA ZA200306737A patent/ZA200306737B/en unknown
- 2003-08-28 IL IL157652A patent/IL157652A/en not_active IP Right Cessation
- 2003-08-28 ZA ZA200306732A patent/ZA200306732B/en unknown
- 2003-08-28 ZA ZA200306731A patent/ZA200306731B/en unknown
- 2003-08-28 ZA ZA200306734A patent/ZA200306734B/en unknown
- 2003-09-09 IS IS6943A patent/IS6943A/is unknown
- 2003-09-09 IS IS6942A patent/IS6942A/is unknown
- 2003-09-10 IS IS6946A patent/IS6946A/is unknown
- 2003-09-12 NO NO20034044A patent/NO20034044L/no unknown
- 2003-09-12 NO NO20034045A patent/NO327114B1/no not_active IP Right Cessation
- 2003-09-12 NO NO20034042A patent/NO326087B1/no not_active IP Right Cessation
-
2006
- 2006-10-13 CY CY20061101477T patent/CY1107525T1/el unknown
-
2007
- 2007-10-30 US US11/928,040 patent/US7625934B2/en not_active Expired - Fee Related
-
2008
- 2008-05-05 US US12/114,901 patent/US7666892B2/en not_active Expired - Fee Related
- 2008-05-06 US US12/115,785 patent/US7754750B2/en not_active Expired - Fee Related
-
2009
- 2009-11-09 JP JP2009256358A patent/JP5140058B2/ja not_active Expired - Fee Related
-
2010
- 2010-01-26 US US12/693,852 patent/US8153673B2/en not_active Expired - Fee Related
- 2010-07-06 US US12/830,763 patent/US20110003853A1/en not_active Abandoned