JP2009537524A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009537524A5 JP2009537524A5 JP2009510986A JP2009510986A JP2009537524A5 JP 2009537524 A5 JP2009537524 A5 JP 2009537524A5 JP 2009510986 A JP2009510986 A JP 2009510986A JP 2009510986 A JP2009510986 A JP 2009510986A JP 2009537524 A5 JP2009537524 A5 JP 2009537524A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- substituted
- independently selected
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 99
- 229910052736 halogen Inorganic materials 0.000 claims 54
- 150000002367 halogens Chemical class 0.000 claims 52
- 229910052739 hydrogen Inorganic materials 0.000 claims 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 15
- 229910052760 oxygen Inorganic materials 0.000 claims 11
- 229910052717 sulfur Inorganic materials 0.000 claims 11
- 229910052799 carbon Inorganic materials 0.000 claims 10
- 125000005842 heteroatom Chemical group 0.000 claims 10
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 8
- -1 phenoxy, benzyl Chemical group 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 150000004292 cyclic ethers Chemical class 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 125000001624 naphthyl group Chemical group 0.000 claims 5
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 4
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000001766 1,2,4-oxadiazol-3-yl group Chemical group [H]C1=NC(*)=NO1 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 claims 2
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 claims 2
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 2
- 102000002072 Non-Receptor Type 1 Protein Tyrosine Phosphatase Human genes 0.000 claims 2
- 108010015847 Non-Receptor Type 1 Protein Tyrosine Phosphatase Proteins 0.000 claims 2
- 102000023984 PPAR alpha Human genes 0.000 claims 2
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 210000000941 bile Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- AHHWIHXENZJRFG-UHFFFAOYSA-N oxetane Chemical compound C1COC1 AHHWIHXENZJRFG-UHFFFAOYSA-N 0.000 claims 2
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 claims 1
- 229940123208 Biguanide Drugs 0.000 claims 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims 1
- 101001078593 Caenorhabditis elegans 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase 1 Proteins 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 229940122502 Cholesterol absorption inhibitor Drugs 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 1
- 229940123232 Glucagon receptor agonist Drugs 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 101000618112 Homo sapiens Sperm-associated antigen 8 Proteins 0.000 claims 1
- 108010016731 PPAR gamma Proteins 0.000 claims 1
- 102000000536 PPAR gamma Human genes 0.000 claims 1
- 229940122054 Peroxisome proliferator-activated receptor delta agonist Drugs 0.000 claims 1
- 102100040918 Pro-glucagon Human genes 0.000 claims 1
- 102100021913 Sperm-associated antigen 8 Human genes 0.000 claims 1
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 claims 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 claims 1
- 229940100389 Sulfonylurea Drugs 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 239000003888 alpha glucosidase inhibitor Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 230000003579 anti-obesity Effects 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 claims 1
- 229940125881 cholesteryl ester transfer protein inhibitor Drugs 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940125542 dual agonist Drugs 0.000 claims 1
- 150000002170 ethers Chemical group 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 239000004031 partial agonist Substances 0.000 claims 1
- 239000002530 phenolic antioxidant Substances 0.000 claims 1
- 125000005493 quinolyl group Chemical group 0.000 claims 1
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 claims 1
- 0 C*c1ccc(C2(*)C(*)(*3)C2(*)*)c3c1 Chemical compound C*c1ccc(C2(*)C(*)(*3)C2(*)*)c3c1 0.000 description 18
- QYKBWEDDHYYSKJ-BZUAXINKSA-N COc(cc(C(F)(F)F)cc1)c1Oc1ccc([C@H]([C@H]2C(O)=O)[C@H]2O2)c2c1 Chemical compound COc(cc(C(F)(F)F)cc1)c1Oc1ccc([C@H]([C@H]2C(O)=O)[C@H]2O2)c2c1 QYKBWEDDHYYSKJ-BZUAXINKSA-N 0.000 description 2
- YPJVPNXMYDTNAI-UHFFFAOYSA-N Cc(cc(C(F)(F)F)cc1)c1Oc1cc(OC2C3C2C(O)=O)c3cc1 Chemical compound Cc(cc(C(F)(F)F)cc1)c1Oc1cc(OC2C3C2C(O)=O)c3cc1 YPJVPNXMYDTNAI-UHFFFAOYSA-N 0.000 description 2
- CELNRZMSPVXGBI-BRWVUGGUSA-N Cc(cc(cc1)C#N)c1Oc1ccc([C@H]([C@H]2C(O)=O)[C@H]2O2)c2c1 Chemical compound Cc(cc(cc1)C#N)c1Oc1ccc([C@H]([C@H]2C(O)=O)[C@H]2O2)c2c1 CELNRZMSPVXGBI-BRWVUGGUSA-N 0.000 description 2
- LUOBBBRZVISPTB-RBSFLKMASA-N OC([C@H]1[C@@H]2Oc3cc(Oc(ccc(C(F)(F)F)c4)c4Cl)ccc3[C@H]12)=O Chemical compound OC([C@H]1[C@@H]2Oc3cc(Oc(ccc(C(F)(F)F)c4)c4Cl)ccc3[C@H]12)=O LUOBBBRZVISPTB-RBSFLKMASA-N 0.000 description 2
- GZQUHARXXKGXOU-GUDVDZBRSA-N OC([C@H]1[C@@H]2Oc3cc(Oc4c(cccc5)c5c(C(F)(F)F)cc4)ccc3[C@H]12)=O Chemical compound OC([C@H]1[C@@H]2Oc3cc(Oc4c(cccc5)c5c(C(F)(F)F)cc4)ccc3[C@H]12)=O GZQUHARXXKGXOU-GUDVDZBRSA-N 0.000 description 2
- QWYXACFTAOUEKR-MUAWNBEISA-N CC(C(C(C)=C1)c2cc(COc3ccc([C@H]([C@H]4C(O)=O)[C@H]4O4)c4c3)ccc2)C=C1OC1OCCCC1 Chemical compound CC(C(C(C)=C1)c2cc(COc3ccc([C@H]([C@H]4C(O)=O)[C@H]4O4)c4c3)ccc2)C=C1OC1OCCCC1 QWYXACFTAOUEKR-MUAWNBEISA-N 0.000 description 1
- MPIBQZHTDRBCBF-OMSMZCRRSA-N CC(c1cc(C(F)(F)F)ccc1)Oc1ccc([C@H]([C@H]2C(O)=O)[C@H]2O2)c2c1 Chemical compound CC(c1cc(C(F)(F)F)ccc1)Oc1ccc([C@H]([C@H]2C(O)=O)[C@H]2O2)c2c1 MPIBQZHTDRBCBF-OMSMZCRRSA-N 0.000 description 1
- MYGQOXDRXSKAIG-WWGYGDJHSA-N CC(c1cc(OC2=CC=CCC2)ccc1)Oc1ccc([C@H]([C@H]2C(O)=O)[C@H]2O2)c2c1 Chemical compound CC(c1cc(OC2=CC=CCC2)ccc1)Oc1ccc([C@H]([C@H]2C(O)=O)[C@H]2O2)c2c1 MYGQOXDRXSKAIG-WWGYGDJHSA-N 0.000 description 1
- BAVUGCZBCKNKRU-JCYYIGJDSA-N CC1(COc(cc2C)cc(C)c2-c2cc(COc3ccc([C@H]([C@H]4C(O)=O)[C@H]4O4)c4c3)ccc2)COC1 Chemical compound CC1(COc(cc2C)cc(C)c2-c2cc(COc3ccc([C@H]([C@H]4C(O)=O)[C@H]4O4)c4c3)ccc2)COC1 BAVUGCZBCKNKRU-JCYYIGJDSA-N 0.000 description 1
- SFSDLEYWWMWOCV-AWFKMRSOSA-N CCOCCOc(cc1C)cc(C)c1-c1cccc(C(C)Oc2cc(O[C@@H]3[C@H]4[C@H]3C(O)=O)c4cc2)c1 Chemical compound CCOCCOc(cc1C)cc(C)c1-c1cccc(C(C)Oc2cc(O[C@@H]3[C@H]4[C@H]3C(O)=O)c4cc2)c1 SFSDLEYWWMWOCV-AWFKMRSOSA-N 0.000 description 1
- ALSREAMCXIKCPL-JCYYIGJDSA-N CCOCCOc(cc1C)cc(C)c1-c1cccc(COc2cc(O[C@@H]3[C@H]4[C@H]3C(O)=O)c4cc2)c1 Chemical compound CCOCCOc(cc1C)cc(C)c1-c1cccc(COc2cc(O[C@@H]3[C@H]4[C@H]3C(O)=O)c4cc2)c1 ALSREAMCXIKCPL-JCYYIGJDSA-N 0.000 description 1
- ACXNFLNFUUONKF-UHFFFAOYSA-N CCOc(cc(C(F)(F)F)cc1)c1Oc1cc(OC2C3C2C(O)=O)c3cc1 Chemical compound CCOc(cc(C(F)(F)F)cc1)c1Oc1cc(OC2C3C2C(O)=O)c3cc1 ACXNFLNFUUONKF-UHFFFAOYSA-N 0.000 description 1
- RITUJRZVAHILMT-ZMSDIMECSA-N C[C@@]([C@H]12)([C@@H]1Oc1c2ccc(Oc(ccc(C(F)(F)F)c2)c2Cl)c1)C(O)=O Chemical compound C[C@@]([C@H]12)([C@@H]1Oc1c2ccc(Oc(ccc(C(F)(F)F)c2)c2Cl)c1)C(O)=O RITUJRZVAHILMT-ZMSDIMECSA-N 0.000 description 1
- RITUJRZVAHILMT-UXLLHSPISA-N C[C@]([C@H]12)([C@@H]1Oc1c2ccc(Oc(ccc(C(F)(F)F)c2)c2Cl)c1)C(O)=O Chemical compound C[C@]([C@H]12)([C@@H]1Oc1c2ccc(Oc(ccc(C(F)(F)F)c2)c2Cl)c1)C(O)=O RITUJRZVAHILMT-UXLLHSPISA-N 0.000 description 1
- CLWSWDKEHZNTBN-UHFFFAOYSA-N Cc(c(Cl)c(C(F)(F)F)cc1)c1Oc1cc(OC2C3C2C(O)=O)c3cc1 Chemical compound Cc(c(Cl)c(C(F)(F)F)cc1)c1Oc1cc(OC2C3C2C(O)=O)c3cc1 CLWSWDKEHZNTBN-UHFFFAOYSA-N 0.000 description 1
- FEZSFYGTADFNRK-WXFUMESZSA-N Cc(cc(cc1)OC)c1-c1ccc(COc2ccc([C@H]([C@H]3C(O)=O)[C@H]3O3)c3c2)cc1 Chemical compound Cc(cc(cc1)OC)c1-c1ccc(COc2ccc([C@H]([C@H]3C(O)=O)[C@H]3O3)c3c2)cc1 FEZSFYGTADFNRK-WXFUMESZSA-N 0.000 description 1
- FJLMPHONYWOOIN-UBFVSLLYSA-N Cc(cc(cc1C)OC)c1-c1cc(COc2cc(O[C@@H]3[C@H]4[C@H]3C(O)=O)c4cc2)ccc1 Chemical compound Cc(cc(cc1C)OC)c1-c1cc(COc2cc(O[C@@H]3[C@H]4[C@H]3C(O)=O)c4cc2)ccc1 FJLMPHONYWOOIN-UBFVSLLYSA-N 0.000 description 1
- WUFPFADKZNIPRQ-UHFFFAOYSA-N Cc(cccc1C)c1-c1cc(CNc2cc(CCC3C4C3C(O)=O)c4cc2)ccc1 Chemical compound Cc(cccc1C)c1-c1cc(CNc2cc(CCC3C4C3C(O)=O)c4cc2)ccc1 WUFPFADKZNIPRQ-UHFFFAOYSA-N 0.000 description 1
- LNXACZGVZUZYST-UHFFFAOYSA-N Cc(cccc1C)c1-c1cc(CNc2ccc(C(C3C4)C3C(O)=O)c4c2)ccc1 Chemical compound Cc(cccc1C)c1-c1cc(CNc2ccc(C(C3C4)C3C(O)=O)c4c2)ccc1 LNXACZGVZUZYST-UHFFFAOYSA-N 0.000 description 1
- OVHLPADVVYZHTQ-UHFFFAOYSA-N Cc(cccc1C)c1-c1cc(COc2cc(OC(C3)C33C(O)=O)c3cc2)ccc1 Chemical compound Cc(cccc1C)c1-c1cc(COc2cc(OC(C3)C33C(O)=O)c3cc2)ccc1 OVHLPADVVYZHTQ-UHFFFAOYSA-N 0.000 description 1
- JFLIFGDDKNGKHQ-UHFFFAOYSA-N Cc1c(CCOc2cc(OC(C3)C33C(O)=O)c3cc2)[s]c(-c2ccccc2)n1 Chemical compound Cc1c(CCOc2cc(OC(C3)C33C(O)=O)c3cc2)[s]c(-c2ccccc2)n1 JFLIFGDDKNGKHQ-UHFFFAOYSA-N 0.000 description 1
- IAZGTNVJABHTAM-BRWVUGGUSA-N Cc1ccc(COc2ccc([C@H]([C@H]3C(O)=O)[C@H]3O3)c3c2)cc1C(F)(F)F Chemical compound Cc1ccc(COc2ccc([C@H]([C@H]3C(O)=O)[C@H]3O3)c3c2)cc1C(F)(F)F IAZGTNVJABHTAM-BRWVUGGUSA-N 0.000 description 1
- CSFVEWCLUOXQSW-KZNAEPCWSA-N Cc1nc(-c2cc(COc3ccc([C@H]([C@H]4C(O)=O)[C@H]4O4)c4c3)ccc2)n[o]1 Chemical compound Cc1nc(-c2cc(COc3ccc([C@H]([C@H]4C(O)=O)[C@H]4O4)c4c3)ccc2)n[o]1 CSFVEWCLUOXQSW-KZNAEPCWSA-N 0.000 description 1
- SSCQQDAUVATJGH-UHFFFAOYSA-N N#Cc(cc1)c(cccc2)c2c1Oc1cc(OC2C3C2C(O)=O)c3cc1 Chemical compound N#Cc(cc1)c(cccc2)c2c1Oc1cc(OC2C3C2C(O)=O)c3cc1 SSCQQDAUVATJGH-UHFFFAOYSA-N 0.000 description 1
- LJRFMXUVUIDZPL-BRWVUGGUSA-N N#Cc1cc(COc2ccc([C@H]([C@H]3C(O)=O)[C@H]3O3)c3c2)ccc1 Chemical compound N#Cc1cc(COc2ccc([C@H]([C@H]3C(O)=O)[C@H]3O3)c3c2)ccc1 LJRFMXUVUIDZPL-BRWVUGGUSA-N 0.000 description 1
- RGDFUUXWGRWLPM-UHFFFAOYSA-N OC(C(C1c(cc2)c3cc2Oc(ccc(C(F)(F)F)c2)c2Cl)C1S3(=O)=O)=O Chemical compound OC(C(C1c(cc2)c3cc2Oc(ccc(C(F)(F)F)c2)c2Cl)C1S3(=O)=O)=O RGDFUUXWGRWLPM-UHFFFAOYSA-N 0.000 description 1
- QIEOCPDUTJTVBQ-UHFFFAOYSA-N OC(C12c(ccc(OCc3cccc(Oc4ccccc4)c3)c3)c3OC1C2)=O Chemical compound OC(C12c(ccc(OCc3cccc(Oc4ccccc4)c3)c3)c3OC1C2)=O QIEOCPDUTJTVBQ-UHFFFAOYSA-N 0.000 description 1
- BSGHSODLEGZZSQ-UHFFFAOYSA-N OC(C12c(ccc(Oc(ccc(C(F)(F)F)c3)c3Cl)c3)c3SC1C2)=O Chemical compound OC(C12c(ccc(Oc(ccc(C(F)(F)F)c3)c3Cl)c3)c3SC1C2)=O BSGHSODLEGZZSQ-UHFFFAOYSA-N 0.000 description 1
- VXWYAFUPFQVBLE-UHFFFAOYSA-N OC(C12c(ccc(Oc(ccc(C(F)(F)F)c3)c3OC3CC3)c3)c3OC1C2)=O Chemical compound OC(C12c(ccc(Oc(ccc(C(F)(F)F)c3)c3OC3CC3)c3)c3OC1C2)=O VXWYAFUPFQVBLE-UHFFFAOYSA-N 0.000 description 1
- APUCMQWVGLGGJQ-UHFFFAOYSA-N OC(C12c(ccc(Oc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3)c3OC1C2)=O Chemical compound OC(C12c(ccc(Oc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3)c3OC1C2)=O APUCMQWVGLGGJQ-UHFFFAOYSA-N 0.000 description 1
- MWAHJPGIECPXGZ-COXVUDFISA-N OC([C@@H]([C@@H]1CC2)[C@H]1c(cc1)c2cc1Oc(ccc(C(F)(F)F)c1)c1Cl)=O Chemical compound OC([C@@H]([C@@H]1CC2)[C@H]1c(cc1)c2cc1Oc(ccc(C(F)(F)F)c1)c1Cl)=O MWAHJPGIECPXGZ-COXVUDFISA-N 0.000 description 1
- KCDUXFUQGUBZGF-RLCCDNCMSA-N OC([C@@H]([C@@H]1COc2c3)[C@H]1c2ccc3Oc(ccc(C(F)(F)F)c1)c1Cl)=O Chemical compound OC([C@@H]([C@@H]1COc2c3)[C@H]1c2ccc3Oc(ccc(C(F)(F)F)c1)c1Cl)=O KCDUXFUQGUBZGF-RLCCDNCMSA-N 0.000 description 1
- KZKYNYVFLIFQHH-KCXAZCMYSA-N OC([C@@H]([C@@H]1Cc2c3)[C@H]1c2ccc3Oc(ccc(C(F)(F)F)c1)c1Cl)=O Chemical compound OC([C@@H]([C@@H]1Cc2c3)[C@H]1c2ccc3Oc(ccc(C(F)(F)F)c1)c1Cl)=O KZKYNYVFLIFQHH-KCXAZCMYSA-N 0.000 description 1
- DHTKTNNAWUTEOF-XBFCOCLRSA-N OC([C@@H]([C@@H]1Cc2c3)[C@H]1c2ccc3Oc(ncc(C(F)(F)F)c1)c1Cl)=O Chemical compound OC([C@@H]([C@@H]1Cc2c3)[C@H]1c2ccc3Oc(ncc(C(F)(F)F)c1)c1Cl)=O DHTKTNNAWUTEOF-XBFCOCLRSA-N 0.000 description 1
- XVBHASCKWDYWKH-VZMGZUMBSA-N OC([C@H]([C@H]12)[C@@H]1OC(C1)C2=CC=C1OCc1ccc(C(F)(F)F)c(F)c1)=O Chemical compound OC([C@H]([C@H]12)[C@@H]1OC(C1)C2=CC=C1OCc1ccc(C(F)(F)F)c(F)c1)=O XVBHASCKWDYWKH-VZMGZUMBSA-N 0.000 description 1
- YIWXJZGXNVQOCX-BZUAXINKSA-N OC([C@H]1[C@@H]2Oc3cc(COc4cccc(C(F)(F)F)c4)ccc3[C@H]12)=O Chemical compound OC([C@H]1[C@@H]2Oc3cc(COc4cccc(C(F)(F)F)c4)ccc3[C@H]12)=O YIWXJZGXNVQOCX-BZUAXINKSA-N 0.000 description 1
- SRQFRFNDVSCCDH-BZUAXINKSA-N OC([C@H]1[C@@H]2Oc3cc(OCc(cc(C(F)(F)F)cc4)c4F)ccc3[C@H]12)=O Chemical compound OC([C@H]1[C@@H]2Oc3cc(OCc(cc(C(F)(F)F)cc4)c4F)ccc3[C@H]12)=O SRQFRFNDVSCCDH-BZUAXINKSA-N 0.000 description 1
- BVRFPEDCGLPRGX-BZUAXINKSA-N OC([C@H]1[C@@H]2Oc3cc(OCc(cc4)ccc4I)ccc3[C@H]12)=O Chemical compound OC([C@H]1[C@@H]2Oc3cc(OCc(cc4)ccc4I)ccc3[C@H]12)=O BVRFPEDCGLPRGX-BZUAXINKSA-N 0.000 description 1
- MUUHSMUPMLWDGK-BZUAXINKSA-N OC([C@H]1[C@@H]2Oc3cc(OCc(cc4C(F)(F)F)ccc4F)ccc3[C@H]12)=O Chemical compound OC([C@H]1[C@@H]2Oc3cc(OCc(cc4C(F)(F)F)ccc4F)ccc3[C@H]12)=O MUUHSMUPMLWDGK-BZUAXINKSA-N 0.000 description 1
- SCLGSBBJVHJOMN-BZUAXINKSA-N OC([C@H]1[C@@H]2Oc3cc(OCc(ccc(C(F)(F)F)c4)c4F)ccc3[C@H]12)=O Chemical compound OC([C@H]1[C@@H]2Oc3cc(OCc(ccc(C(F)(F)F)c4)c4F)ccc3[C@H]12)=O SCLGSBBJVHJOMN-BZUAXINKSA-N 0.000 description 1
- UKRQPIYHAXBBSE-BZUAXINKSA-N OC([C@H]1[C@@H]2Oc3cc(OCc4c(C(F)(F)F)cccc4)ccc3[C@H]12)=O Chemical compound OC([C@H]1[C@@H]2Oc3cc(OCc4c(C(F)(F)F)cccc4)ccc3[C@H]12)=O UKRQPIYHAXBBSE-BZUAXINKSA-N 0.000 description 1
- KAMCYPCZTDMMSQ-BZUAXINKSA-N OC([C@H]1[C@@H]2Oc3cc(OCc4ccc(C(F)(F)F)cc4)ccc3[C@H]12)=O Chemical compound OC([C@H]1[C@@H]2Oc3cc(OCc4ccc(C(F)(F)F)cc4)ccc3[C@H]12)=O KAMCYPCZTDMMSQ-BZUAXINKSA-N 0.000 description 1
- HRWRXUFVPIPFSU-BZUAXINKSA-N OC([C@H]1[C@@H]2Oc3cc(OCc4cccc(C(F)(F)F)c4)ccc3[C@H]12)=O Chemical compound OC([C@H]1[C@@H]2Oc3cc(OCc4cccc(C(F)(F)F)c4)ccc3[C@H]12)=O HRWRXUFVPIPFSU-BZUAXINKSA-N 0.000 description 1
- UDXHYQYZJASGRT-BZUAXINKSA-N OC([C@H]1[C@@H]2Oc3cc(OCc4cccc(I)c4)ccc3[C@H]12)=O Chemical compound OC([C@H]1[C@@H]2Oc3cc(OCc4cccc(I)c4)ccc3[C@H]12)=O UDXHYQYZJASGRT-BZUAXINKSA-N 0.000 description 1
- FFTCSDPIZBSCJX-BZUAXINKSA-N [O-][N+](c1cc(COc2ccc([C@H]([C@H]3C(O)=O)[C@H]3O3)c3c2)ccc1)=O Chemical compound [O-][N+](c1cc(COc2ccc([C@H]([C@H]3C(O)=O)[C@H]3O3)c3c2)ccc1)=O FFTCSDPIZBSCJX-BZUAXINKSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80054206P | 2006-05-15 | 2006-05-15 | |
| US60/800,542 | 2006-05-15 | ||
| US83630806P | 2006-08-08 | 2006-08-08 | |
| US60/836,308 | 2006-08-08 | ||
| PCT/US2007/011372 WO2007136573A2 (en) | 2006-05-15 | 2007-05-11 | Antidiabetic bicyclic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009537524A JP2009537524A (ja) | 2009-10-29 |
| JP2009537524A5 true JP2009537524A5 (enExample) | 2010-06-03 |
| JP5271895B2 JP5271895B2 (ja) | 2013-08-21 |
Family
ID=38573088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009510986A Expired - Fee Related JP5271895B2 (ja) | 2006-05-15 | 2007-05-11 | 抗糖尿病性の二環式化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7442808B2 (enExample) |
| EP (1) | EP2021327B1 (enExample) |
| JP (1) | JP5271895B2 (enExample) |
| AR (1) | AR060916A1 (enExample) |
| AT (1) | ATE552245T1 (enExample) |
| AU (1) | AU2007254325B2 (enExample) |
| CA (1) | CA2651153C (enExample) |
| DO (1) | DOP2007000099A (enExample) |
| PE (1) | PE20080069A1 (enExample) |
| TW (1) | TW200812992A (enExample) |
| WO (2) | WO2007136573A2 (enExample) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7465804B2 (en) * | 2005-05-20 | 2008-12-16 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders |
| US7582803B2 (en) * | 2005-09-14 | 2009-09-01 | Amgen Inc. | Conformationally constrained 3-(4-hydroxy-phenyl)-substituted-propanoic acids useful for treating metabolic disorders |
| AU2007225208A1 (en) * | 2006-03-14 | 2007-09-20 | Amgen Inc. | Bicyclic carboxylic acid derivatives useful for treating metabolic disorders |
| EP2061760A1 (en) * | 2006-09-07 | 2009-05-27 | Amgen, Inc | Benzo-fused compounds for use in treating metabolic disorders |
| CA2662305C (en) | 2006-09-07 | 2012-04-17 | Amgen Inc. | Heterocyclic gpr40 modulators |
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| ES2446419T3 (es) * | 2007-04-16 | 2014-03-07 | Amgen, Inc | Moduladores de GPR40 de ácidos bifenilfenoxi, tiofenil y aminofenilpropanoico sustituidos |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JP5591706B2 (ja) | 2007-10-10 | 2014-09-17 | アムジエン・インコーポレーテツド | 置換ビフェニルｇｐｒ４０調節因子 |
| AU2008319418B2 (en) * | 2007-10-29 | 2013-08-15 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| WO2009097995A1 (de) * | 2008-02-07 | 2009-08-13 | Sanofi-Aventis | Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2009111056A1 (en) * | 2008-03-06 | 2009-09-11 | Amgen Inc. | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders |
| PL2280704T3 (pl) * | 2008-03-31 | 2015-10-30 | Cymabay Therapeutics Inc | Związki oksymetylenoarylowe i ich zastosowania |
| EP2355660A4 (en) * | 2008-10-13 | 2012-05-02 | Biovista Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT OF MULTIPLE SCLEROSIS |
| AU2009303475B2 (en) * | 2008-10-15 | 2012-09-13 | Amgen Inc. | Spirocyclic GPR40 modulators |
| WO2010085528A1 (en) | 2009-01-23 | 2010-07-29 | Schering Corporation | Bridged and fused antidiabetic compounds |
| EP2389226B1 (en) | 2009-01-23 | 2013-11-20 | Merck Sharp & Dohme Corp. | Bridged and fused heterocyclic antidiabetic compounds |
| EP2393810A1 (en) | 2009-02-05 | 2011-12-14 | Schering Corporation | Phthalazine-containing antidiabetic compounds |
| US20120172351A1 (en) | 2009-06-09 | 2012-07-05 | Nobuyuki Negoro | Novel fused cyclic compound and use thereof |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN103012343B (zh) * | 2011-09-26 | 2015-04-08 | 上海恒瑞医药有限公司 | 稠合环类衍生物、其制备方法及其在医药上的应用 |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| DK2797888T3 (en) * | 2011-12-31 | 2016-09-19 | Beigene Ltd | Fused tricyclic compounds as RAF kinase inhibitors |
| CN105348299B (zh) * | 2011-12-31 | 2017-12-15 | 百济神州有限公司 | 作为raf激酶抑制剂的稠合三环化合物 |
| AU2013290100A1 (en) | 2012-07-11 | 2015-01-29 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| CN104684907A (zh) * | 2012-08-02 | 2015-06-03 | 默沙东公司 | 抗糖尿病的三环化合物 |
| US20140045746A1 (en) | 2012-08-02 | 2014-02-13 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| WO2014019186A1 (en) * | 2012-08-02 | 2014-02-06 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| CN105142621A (zh) | 2012-10-24 | 2015-12-09 | 国家健康科学研究所 | 用于预防或治疗糖尿病和促进β-细胞存活的TPL2激酶抑制剂 |
| JP2016516004A (ja) | 2013-02-22 | 2016-06-02 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 抗糖尿病二環式化合物 |
| TWI640518B (zh) * | 2013-05-21 | 2018-11-11 | 百濟神州生物科技有限公司 | 作爲ｒａｆ激酶抑制劑的稠合三環化合物 |
| WO2014206344A1 (en) * | 2013-06-28 | 2014-12-31 | Beigene, Ltd. | Fused tricyclic amide compounds as multiple kinase inhibitors |
| WO2014206343A1 (en) | 2013-06-28 | 2014-12-31 | Beigene, Ltd. | Fused tricyclic urea compounds as raf kinase and/or raf kinase dimer inhibitors |
| EP3417851B1 (en) | 2013-09-09 | 2020-07-22 | Peloton Therapeutics, Inc. | Aryl ethers and uses thereof |
| SMT202300039T1 (it) | 2013-09-13 | 2023-03-17 | Beigene Switzerland Gmbh | Anticorpi anti-pd1 e loro uso come terapia e per diagnostica |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| CN105722841A (zh) | 2013-11-14 | 2016-06-29 | 卡迪拉保健有限公司 | 新型杂环化合物 |
| US10519115B2 (en) | 2013-11-15 | 2019-12-31 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| WO2015084692A1 (en) * | 2013-12-04 | 2015-06-11 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| WO2015089809A1 (en) | 2013-12-19 | 2015-06-25 | Merck Sharp & Dohme Corp. | Antidiabetic substituted heteroaryl compounds |
| WO2015089842A1 (en) * | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Novel tricyclic calcium sensing receptor antagonists for the treatment of osteoporosis |
| US10059667B2 (en) | 2014-02-06 | 2018-08-28 | Merck Sharp & Dohme Corp. | Antidiabetic compounds |
| WO2015176267A1 (en) * | 2014-05-22 | 2015-11-26 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| TWI726608B (zh) | 2014-07-03 | 2021-05-01 | 英屬開曼群島商百濟神州有限公司 | 抗pd-l1抗體及其作為治療及診斷之用途 |
| KR102524920B1 (ko) | 2014-07-22 | 2023-04-25 | 아폴로믹스 인코포레이티드 | 항-pd-1 항체 |
| SG10201901057UA (en) | 2014-08-05 | 2019-03-28 | Cb Therapeutics Inc | Anti-pd-l1 antibodies |
| WO2016022448A1 (en) | 2014-08-08 | 2016-02-11 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| US10100042B2 (en) | 2014-08-08 | 2018-10-16 | Merck Sharp & Dohme Corp. | [5,6]—fused bicyclic antidiabetic compounds |
| WO2016022742A1 (en) | 2014-08-08 | 2016-02-11 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| WO2016019587A1 (en) | 2014-08-08 | 2016-02-11 | Merck Sharp & Dohme Corp. | [7, 6]-fused bicyclic antidiabetic compounds |
| EP3268362B1 (en) | 2015-03-11 | 2021-10-20 | Peloton Therapeutics, Inc. | Substituted pyridines and uses thereof |
| US10807948B2 (en) | 2015-03-11 | 2020-10-20 | Peloton Therapeutics, Inc. | Aromatic compounds and uses thereof |
| WO2016145032A1 (en) | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Compositions for use in treating pulmonary arterial hypertension |
| US10512626B2 (en) | 2015-03-11 | 2019-12-24 | Peloton Therapeautics, Inc. | Compositions for use in treating glioblastoma |
| EP3273981B1 (en) | 2015-03-24 | 2020-04-29 | INSERM - Institut National de la Santé et de la Recherche Médicale | Method and pharmaceutical composition for use in the treatment of diabetes |
| AU2016248376B2 (en) | 2015-04-15 | 2020-10-08 | Beone Medicines I Gmbh | Maleate salts of a B-RAF kinase inhibitor, crystalline forms, methods of preparation, and uses therefore |
| US10335388B2 (en) | 2015-04-17 | 2019-07-02 | Peloton Therapeutics, Inc. | Combination therapy of a HIF-2-alpha inhibitor and an immunotherapeutic agent and uses thereof |
| JP6175519B2 (ja) * | 2016-01-04 | 2017-08-09 | ベイジーン リミテッド | Ｒａｆキナーゼ阻害剤としての縮合三環式化合物 |
| EP3436003B1 (en) | 2016-03-29 | 2023-08-23 | Merck Sharp & Dohme LLC | Antidiabetic bicyclic compounds |
| WO2018007885A1 (en) | 2016-07-05 | 2018-01-11 | Beigene, Ltd. | COMBINATION OF A PD-l ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER |
| WO2018026890A1 (en) | 2016-08-03 | 2018-02-08 | Cymabay Therapeutics | Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions |
| CN110087680B (zh) | 2016-08-19 | 2024-03-19 | 百济神州有限公司 | 使用包含btk抑制剂的组合产品治疗癌症 |
| WO2018106518A1 (en) | 2016-12-06 | 2018-06-14 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
| EP3573989A4 (en) | 2017-01-25 | 2020-11-18 | Beigene, Ltd. | CRYSTALLINE FORMS OF (S) -7- (1- (BUT-2-YNOYL) PIPERIDIN-4-YL) -2- (4-PHENOXYPHENYL) -4, 5, 6, 7-TETRAHY DROPYRAZOLO [1, 5-A ] PYRIMIDINE-3-CARBOXAMIDE, PREPARATION AND ASSOCIATED USES |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| EP3645569A4 (en) | 2017-06-26 | 2021-03-24 | BeiGene, Ltd. | IMMUNOTHERAPY FOR LIVER CELL CARCINOMA |
| US11225471B2 (en) | 2017-11-16 | 2022-01-18 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| US11786529B2 (en) | 2017-11-29 | 2023-10-17 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors |
| WO2019160882A1 (en) | 2018-02-13 | 2019-08-22 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| TWI873092B (zh) | 2018-04-06 | 2025-02-21 | 美商百歐克斯製藥公司 | 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑 |
| KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| PE20210642A1 (es) | 2018-07-13 | 2021-03-23 | Gilead Sciences Inc | Inhibidores de pd-1/pd-l1 |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| TWI849043B (zh) | 2019-01-25 | 2024-07-21 | 英屬開曼群島商百濟神州有限公司 | B-raf激酶二聚體抑制劑之穩定固體分散體、製備方法及其用途 |
| JP2022552655A (ja) | 2019-10-07 | 2022-12-19 | キャリーオペ，インク． | Ｇｐｒ１１９アゴニスト |
| CN110776504B (zh) * | 2019-11-29 | 2021-07-30 | 扬州工业职业技术学院 | 一种苯异噁唑乙氧基环丁胺衍生物及其制备方法与应用 |
| MX2022010548A (es) | 2020-02-28 | 2022-09-23 | Kallyope Inc | Agonistas de gpr40. |
| MX2022014505A (es) | 2020-05-19 | 2022-12-13 | Kallyope Inc | Activadores de la ampk. |
| EP4165029B1 (en) | 2020-06-15 | 2024-07-17 | DSM IP Assets B.V. | Process for the manufacture of alkylamidothiazoles |
| CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
| CN119528857B (zh) * | 2024-10-14 | 2026-07-28 | 上海毕臣生化科技有限公司 | 一种5-甲氧基-3-苯并呋喃酮的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3514491A (en) * | 1967-10-13 | 1970-05-26 | Parke Davis & Co | Derivatives of 6-aminopenicillanic acid and of 7-aminocephalosporanic acid |
| SE0100733D0 (sv) | 2001-03-05 | 2001-03-05 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
| SE0102867D0 (sv) * | 2001-08-28 | 2001-08-28 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
| US6907879B2 (en) * | 2002-02-04 | 2005-06-21 | Ndt | Agent delivery and aspiration device |
| KR20050033663A (ko) | 2002-09-05 | 2005-04-12 | 메디비르 아베 | 비-뉴클레오시드 역전사효소 억제제 |
| JP4805552B2 (ja) * | 2003-05-30 | 2011-11-02 | 武田薬品工業株式会社 | 縮合環化合物 |
| DE602004024584D1 (de) * | 2004-01-08 | 2010-01-21 | Medivir Ab | Inhibitoren der nicht-nukleotidischen reversen transkriptase |
-
2007
- 2007-05-11 AU AU2007254325A patent/AU2007254325B2/en not_active Ceased
- 2007-05-11 EP EP07794762A patent/EP2021327B1/en active Active
- 2007-05-11 JP JP2009510986A patent/JP5271895B2/ja not_active Expired - Fee Related
- 2007-05-11 WO PCT/US2007/011372 patent/WO2007136573A2/en not_active Ceased
- 2007-05-11 WO PCT/US2007/011369 patent/WO2007136572A2/en not_active Ceased
- 2007-05-11 CA CA2651153A patent/CA2651153C/en not_active Expired - Fee Related
- 2007-05-11 US US11/801,841 patent/US7442808B2/en active Active
- 2007-05-11 AT AT07794762T patent/ATE552245T1/de active
- 2007-05-11 PE PE2007000575A patent/PE20080069A1/es not_active Application Discontinuation
- 2007-05-14 AR ARP070102069A patent/AR060916A1/es not_active Application Discontinuation
- 2007-05-14 DO DO2007000099A patent/DOP2007000099A/es unknown
- 2007-05-14 TW TW096117055A patent/TW200812992A/zh unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010516715A5 (enExample) | ||
| JP2009522292A5 (enExample) | ||
| JP2004536115A5 (enExample) | ||
| RU2009132092A (ru) | Конденсированные ароматические дифторметанфосфонаты в качестве ингибиторов протеинтирозинфосфатазы ib (ptp -1b) | |
| JP2006500384A5 (enExample) | ||
| JP2007532651A5 (enExample) | ||
| JP6238460B2 (ja) | 脂質異常症治療剤 | |
| JP7013369B2 (ja) | Ｅｚｈ２阻害剤により卵巣の悪性ラブドイド腫瘍（ｍｒｔｏ）／高カルシウム血症型の卵巣の小細胞癌（ｓｃｃｏｈｔ）を処置するための方法 | |
| JP2011500562A5 (enExample) | ||
| JP2015525782A5 (enExample) | ||
| JP2014530900A5 (enExample) | ||
| JP2018535963A5 (enExample) | ||
| JP2004532266A5 (enExample) | ||
| JP2010503688A5 (enExample) | ||
| JP2018517746A5 (enExample) | ||
| JP2010524932A5 (enExample) | ||
| JP2020506951A5 (enExample) | ||
| JP2013544846A5 (enExample) | ||
| JP2018518537A5 (enExample) | ||
| JP2010523476A5 (enExample) | ||
| JP2009522277A5 (enExample) | ||
| JP2012506896A5 (enExample) | ||
| RU2005105053A (ru) | Новые производные пиперидина для применения в лечении болезненных состояний, опосредованных хемокинами | |
| JP2013532726A5 (enExample) | ||
| JP2017516771A5 (enExample) |