|
CA2771190C
(en)
|
2009-08-17 |
2020-01-21 |
Memorial Sloan-Kettering Cancer Center |
Heat shock protein binding compounds, compositions, and methods for making and using same
|
|
US11466017B2
(en)
|
2011-03-10 |
2022-10-11 |
Board Of Regents, The University Of Texas System |
Heterocyclic inhibitors of PTPN11
|
|
US10093646B2
(en)
|
2014-01-17 |
2018-10-09 |
Novartis Ag |
1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
|
|
JO3517B1
(ar)
|
2014-01-17 |
2020-07-05 |
Novartis Ag |
ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
|
|
ES2699354T3
(es)
|
2014-01-17 |
2019-02-08 |
Novartis Ag |
Derivados de 1-(triazin-3-il/piridazin-3-il)-piper(-azin)idina y composiciones de las mismas para inhibir la actividad de SHP2
|
|
WO2015175707A1
(en)
*
|
2014-05-13 |
2015-11-19 |
Memorial Sloan Kettering Cancer Center |
Hsp70 modulators and methods for making and using the same
|
|
EP3310779B1
(en)
|
2015-06-19 |
2019-05-08 |
Novartis AG |
Compounds and compositions for inhibiting the activity of shp2
|
|
ES2824576T3
(es)
*
|
2015-06-19 |
2021-05-12 |
Novartis Ag |
Compuestos y composiciones para inhibir la actividad de SHP2
|
|
ES2805232T3
(es)
|
2015-06-19 |
2021-02-11 |
Novartis Ag |
Compuestos y composiciones para inhibir la actividad de SHP2
|
|
AU2017274199B2
(en)
|
2016-05-31 |
2021-09-23 |
Board Of Regents, The University Of Texas System |
Heterocyclic inhibitors of PTPN11
|
|
EA202092442A3
(ru)
*
|
2016-06-07 |
2021-08-31 |
Джакобио Фармасьютикалс Ко., Лтд. |
Новые гетероциклические производные, применимые в качестве ингибиторов shp2
|
|
CN109415360B
(zh)
|
2016-06-14 |
2021-11-02 |
诺华股份有限公司 |
用于抑制shp2活性的化合物和组合物
|
|
KR102598895B1
(ko)
|
2016-07-12 |
2023-11-07 |
레볼루션 메디슨즈, 인크. |
다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진
|
|
US11529347B2
(en)
|
2016-09-22 |
2022-12-20 |
Relay Therapeutics, Inc. |
SHP2 phosphatase inhibitors and methods of use thereof
|
|
TW202500565A
(zh)
|
2016-10-24 |
2025-01-01 |
美商傳達治療有限公司 |
Shp2磷酸酶抑制劑及其使用方法
|
|
US20190343836A1
(en)
*
|
2017-01-10 |
2019-11-14 |
Novartis Ag |
Pharmaceutical combination comprising an alk inhibitor and a shp2 inhibitor
|
|
KR20190110588A
(ko)
|
2017-01-23 |
2019-09-30 |
레볼루션 메디슨즈, 인크. |
알로스테릭 shp2 억제제로서의 피리딘 화합물
|
|
JP7240319B2
(ja)
|
2017-01-23 |
2023-03-15 |
レヴォリューション・メディスンズ,インコーポレイテッド |
アロステリックshp2阻害剤としての二環式化合物
|
|
AU2018239542C1
(en)
|
2017-03-23 |
2021-02-11 |
Jacobio Pharmaceuticals Co., Ltd. |
Novel heterocyclic derivatives useful as SHP2 inhibitors
|
|
WO2018218133A1
(en)
|
2017-05-26 |
2018-11-29 |
Relay Therapeutics, Inc. |
Pyrazolo[3,4-b]pyrazine derivatives as shp2 phosphatase inhibitors
|
|
WO2019051084A1
(en)
|
2017-09-07 |
2019-03-14 |
Revolution Medicines, Inc. |
SHP2 INHIBITOR COMPOSITIONS AND METHODS OF TREATING CANCER
|
|
TW202517628A
(zh)
|
2017-09-11 |
2025-05-01 |
美商克魯松藥物公司 |
Shp2之八氫環戊烷并[c]吡咯別構抑制劑
|
|
US11701354B2
(en)
|
2017-09-29 |
2023-07-18 |
D. E. Shaw Research, Llc |
Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors
|
|
MX2020003579A
(es)
|
2017-10-12 |
2020-07-22 |
Revolution Medicines Inc |
Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos.
|
|
TW201927791A
(zh)
*
|
2017-12-15 |
2019-07-16 |
美商銳新醫藥公司 |
作為變構shp2抑制劑的多環化合物
|
|
SG11202007740TA
(en)
|
2018-02-13 |
2020-09-29 |
Shanghai Blueray Biopharma Co Ltd |
Pyrimidine-fused cyclic compound, preparation method therefor and application thereof
|
|
JP7326305B2
(ja)
|
2018-03-02 |
2023-08-15 |
大塚製薬株式会社 |
医薬化合物
|
|
WO2019183364A1
(en)
|
2018-03-21 |
2019-09-26 |
Relay Therapeutics, Inc. |
Pyrazolo[3,4-b]pyrazine shp2 phosphatase inhibitors and methods of use thereof
|
|
CN112368272B
(zh)
*
|
2018-03-21 |
2023-04-21 |
苏州浦合医药科技有限公司 |
Shp2抑制剂及其用途
|
|
BR112020019385A2
(pt)
|
2018-03-21 |
2021-03-30 |
Relay Therapeutics, Inc. |
Inibidores de shp2 fosfatase e métodos de uso dos mesmos
|
|
CA3096535A1
(en)
|
2018-04-10 |
2019-10-17 |
Revolution Medicines, Inc. |
Shp2 inhibitor compositions, methods for treating cancer and methods for identifying a subject with shp2 mutations
|
|
MX2020011528A
(es)
|
2018-05-02 |
2021-02-09 |
Navire Pharma Inc |
Inhibidores heterociclicos sustituidos de ptpn11.
|
|
MX2021000795A
(es)
|
2018-07-24 |
2021-04-12 |
Taiho Pharmaceutical Co Ltd |
Compuestos heterociclicos para inhibir la actividad de shp2.
|
|
SG11202100199UA
(en)
|
2018-08-10 |
2021-02-25 |
Navire Pharma Inc |
6-(4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3h)-one derivatives and related compounds as ptpn11 (shp2) inhibitors for treating cancer
|
|
CN112996795B
(zh)
|
2018-09-18 |
2024-11-12 |
尼坎治疗公司 |
作为src同源-2磷酸酶抑制剂的稠合的三环衍生物
|
|
US20210393623A1
(en)
|
2018-09-26 |
2021-12-23 |
Jacobio Pharmaceuticals Co., Ltd. |
Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors
|
|
KR20210068472A
(ko)
*
|
2018-09-29 |
2021-06-09 |
노파르티스 아게 |
Shp2 활성의 억제를 위한 화합물 및 조성물의 제조
|
|
IL305106B2
(en)
|
2018-09-29 |
2025-08-01 |
Novartis Ag |
Process of manufacture of a compound for inhibiting the activity of shp2
|
|
US11179397B2
(en)
|
2018-10-03 |
2021-11-23 |
Gilead Sciences, Inc. |
Imidazopyrimidine derivatives
|
|
WO2020076723A1
(en)
|
2018-10-08 |
2020-04-16 |
Revolution Medicines, Inc. |
Shp2 inhibitor compositions for use in treating cancer
|
|
MA53921A
(fr)
|
2018-10-17 |
2022-01-26 |
Array Biopharma Inc |
Inhibiteurs de protéine tyrosine phosphatase
|
|
CN117143079A
(zh)
*
|
2018-11-06 |
2023-12-01 |
上海奕拓医药科技有限责任公司 |
一种螺芳环化合物及其应用
|
|
CA3120791A1
(en)
|
2018-11-30 |
2020-06-04 |
Tuojie Biotech (Shanghai) Co., Ltd. |
Pyrimidine and five-membered nitrogen heterocycle derivative, preparation method therefor, and medical uses thereof
|
|
CA3112129A1
(en)
|
2018-12-05 |
2020-06-11 |
Mirati Therapeutics, Inc. |
Combination therapies
|
|
CN113316574B
(zh)
*
|
2019-01-31 |
2024-01-30 |
贝达药业股份有限公司 |
Shp2抑制剂及其应用
|
|
KR20210146287A
(ko)
|
2019-03-01 |
2021-12-03 |
레볼루션 메디슨즈, 인크. |
이환식 헤테로아릴 화합물 및 이의 용도
|
|
CN113727758A
(zh)
|
2019-03-01 |
2021-11-30 |
锐新医药公司 |
双环杂环基化合物及其用途
|
|
CA3127361A1
(en)
|
2019-03-07 |
2020-09-10 |
Merck Patent Gmbh |
Carboxamide-pyrimidine derivatives as shp2 antagonists
|
|
BR112021018664A2
(pt)
|
2019-04-02 |
2021-11-23 |
Array Biopharma Inc |
Inibidores de proteína tirosina fosfatase
|
|
US11001561B2
(en)
|
2019-04-08 |
2021-05-11 |
Merck Patent Gmbh |
Pyrimidinone derivatives as SHP2 antagonists
|
|
WO2020259679A1
(zh)
|
2019-06-28 |
2020-12-30 |
上海拓界生物医药科技有限公司 |
嘧啶并五元氮杂环类衍生物、其制备方法及其在医药上的应用
|
|
CN111704611B
(zh)
*
|
2019-07-25 |
2022-01-14 |
上海凌达生物医药有限公司 |
一类芳基螺环类shp2抑制剂化合物、制备方法和用途
|
|
EP3772513A1
(en)
|
2019-08-09 |
2021-02-10 |
C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening |
Shp2 inhibitors
|
|
GB201911928D0
(en)
|
2019-08-20 |
2019-10-02 |
Otsuka Pharma Co Ltd |
Pharmaceutical compounds
|
|
WO2021061515A1
(en)
*
|
2019-09-23 |
2021-04-01 |
Synblia Therapeutics, Inc. |
Shp2 inhibitors and uses thereof
|
|
WO2021061706A1
(en)
|
2019-09-24 |
2021-04-01 |
Relay Therapeutics, Inc. |
Shp2 phosphatase inhibitors and methods of making and using the same
|
|
JP7823816B2
(ja)
|
2019-11-04 |
2026-03-04 |
レヴォリューション・メディスンズ,インコーポレイテッド |
Ras阻害剤
|
|
EP4054719B1
(en)
|
2019-11-04 |
2026-02-11 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
KR20220109407A
(ko)
|
2019-11-04 |
2022-08-04 |
레볼루션 메디슨즈, 인크. |
Ras 억제제
|
|
BR112022008858A2
(pt)
|
2019-11-08 |
2022-09-06 |
Revolution Medicines Inc |
Composto, composição farmacêutica e métodos para inibir sos1 em um sujeito, para inibir a interação de sos1 e uma proteína, para tratar ou prevenir uma doença e para tratar ou prevenir câncer
|
|
WO2021108683A1
(en)
|
2019-11-27 |
2021-06-03 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
|
AU2020408562A1
(en)
|
2019-12-20 |
2022-06-23 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
CN114929279A
(zh)
|
2020-01-07 |
2022-08-19 |
锐新医药公司 |
Shp2抑制剂给药和治疗癌症的方法
|
|
CN114761394B
(zh)
*
|
2020-01-16 |
2024-03-29 |
浙江海正药业股份有限公司 |
吡啶或嘧啶类衍生物及其制备方法和用途
|
|
CN113135910A
(zh)
*
|
2020-01-19 |
2021-07-20 |
北京诺诚健华医药科技有限公司 |
嘧啶-4(3h)-酮类杂环化合物、其制备方法及其在医药学上的应用
|
|
CN114846005B
(zh)
*
|
2020-01-21 |
2024-04-02 |
贝达药业股份有限公司 |
Shp2抑制剂及其应用
|
|
TW202146021A
(zh)
|
2020-02-28 |
2021-12-16 |
瑞士商諾華公司 |
包含達拉菲尼、erk抑制劑和shp2抑制劑之三重藥物組合
|
|
CA3183032A1
(en)
|
2020-06-18 |
2021-12-23 |
Mallika Singh |
Methods for delaying, preventing, and treating acquired resistance to ras inhibitors
|
|
TW202216723A
(zh)
|
2020-07-08 |
2022-05-01 |
瑞士商諾華公司 |
用於抑制shp2活性的化合物及組成物之製造
|
|
CN115916765B
(zh)
*
|
2020-07-10 |
2025-04-18 |
浙江海正药业股份有限公司 |
吡啶或嘧啶类衍生物及其制备方法和用途
|
|
MX2023002248A
(es)
|
2020-09-03 |
2023-05-16 |
Revolution Medicines Inc |
Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2.
|
|
CR20230165A
(es)
|
2020-09-15 |
2023-06-02 |
Revolution Medicines Inc |
Derivados indólicos como inhibidores de ras en el tratamiento del cáncer
|
|
US12162893B2
(en)
|
2020-09-23 |
2024-12-10 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
WO2022133345A1
(en)
|
2020-12-18 |
2022-06-23 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
CN117396472A
(zh)
|
2020-12-22 |
2024-01-12 |
上海齐鲁锐格医药研发有限公司 |
Sos1抑制剂及其用途
|
|
EP4039685A1
(en)
|
2021-02-08 |
2022-08-10 |
Irbm S.P.A. |
Azabicyclic shp2 inhibitors
|
|
EP4067358A1
(en)
|
2021-04-02 |
2022-10-05 |
C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening |
(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo[1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
|
|
CR20230558A
(es)
|
2021-05-05 |
2024-01-24 |
Revolution Medicines Inc |
Inhibidores de ras para el tratamiento del cáncer
|
|
WO2022235866A1
(en)
|
2021-05-05 |
2022-11-10 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
|
IL308193A
(en)
|
2021-05-05 |
2024-01-01 |
Revolution Medicines Inc |
RAS inhibitors
|
|
WO2022259157A1
(en)
|
2021-06-09 |
2022-12-15 |
Novartis Ag |
A triple pharmaceutical combination comprising dabrafenib, trametinib and a shp2 inhibitor
|
|
TW202317100A
(zh)
|
2021-06-23 |
2023-05-01 |
瑞士商諾華公司 |
包含kras g12c抑制劑的藥物組合及其用於治療癌症之用途
|
|
TW202327569A
(zh)
|
2021-09-01 |
2023-07-16 |
瑞士商諾華公司 |
包含tead抑制劑的藥物組合及其用於癌症治療之用途
|
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
|
CN119136806A
(zh)
|
2022-03-08 |
2024-12-13 |
锐新医药公司 |
用于治疗免疫难治性肺癌的方法
|
|
WO2023240263A1
(en)
|
2022-06-10 |
2023-12-14 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
|
EP4345101A1
(en)
|
2022-09-29 |
2024-04-03 |
Irbm S.P.A. |
Azole derivatives as shp2 inhibitors
|
|
AU2024241633A1
(en)
|
2023-03-30 |
2025-11-06 |
Revolution Medicines, Inc. |
Compositions for inducing ras gtp hydrolysis and uses thereof
|
|
WO2024211663A1
(en)
|
2023-04-07 |
2024-10-10 |
Revolution Medicines, Inc. |
Condensed macrocyclic compounds as ras inhibitors
|
|
PE20260039A1
(es)
|
2023-04-07 |
2026-01-09 |
Revolution Medicines Inc |
Inhibidores macrociclicos de ras
|
|
TW202448897A
(zh)
|
2023-04-14 |
2024-12-16 |
美商銳新醫藥公司 |
Ras抑制劑之結晶形式、含有其之組合物及其使用方法
|
|
CN121100123A
(zh)
|
2023-04-14 |
2025-12-09 |
锐新医药公司 |
Ras抑制剂的结晶形式
|
|
WO2024229406A1
(en)
|
2023-05-04 |
2024-11-07 |
Revolution Medicines, Inc. |
Combination therapy for a ras related disease or disorder
|
|
US20250049810A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2025034919A1
(en)
|
2023-08-08 |
2025-02-13 |
Quanta Therapeutics, Inc. |
Combination therapies with kras modulators
|
|
TW202530228A
(zh)
|
2023-10-12 |
2025-08-01 |
美商銳新醫藥公司 |
Ras抑制劑
|
|
WO2025106901A1
(en)
|
2023-11-17 |
2025-05-22 |
Quanta Therapeutics, Inc. |
Combination cancer therapies with a kras modulator and an rtk-mapk pathway inhibitor
|
|
TW202542151A
(zh)
|
2023-12-22 |
2025-11-01 |
美商銳格醫藥有限公司 |
Sos1抑制劑及其用途
|
|
WO2025171296A1
(en)
|
2024-02-09 |
2025-08-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
TW202547461A
(zh)
|
2024-05-17 |
2025-12-16 |
美商銳新醫藥公司 |
Ras抑制劑
|
|
WO2025255438A1
(en)
|
2024-06-07 |
2025-12-11 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2025265060A1
(en)
|
2024-06-21 |
2025-12-26 |
Revolution Medicines, Inc. |
Therapeutic compositions and methods for managing treatment-related effects
|
|
WO2026015796A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015790A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015825A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Use of ras inhibitor for treating pancreatic cancer
|
|
WO2026015801A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026050446A1
(en)
|
2024-08-29 |
2026-03-05 |
Revolution Medicines, Inc. |
Ras inhibitors
|