MX2020008754A - Compuestos farmaceuticos. - Google Patents

Compuestos farmaceuticos.

Info

Publication number
MX2020008754A
MX2020008754A MX2020008754A MX2020008754A MX2020008754A MX 2020008754 A MX2020008754 A MX 2020008754A MX 2020008754 A MX2020008754 A MX 2020008754A MX 2020008754 A MX2020008754 A MX 2020008754A MX 2020008754 A MX2020008754 A MX 2020008754A
Authority
MX
Mexico
Prior art keywords
pharmaceutical compounds
compounds
tautomer
solvate
substituents
Prior art date
Application number
MX2020008754A
Other languages
English (en)
Inventor
Christopher Charles Frederick Hamlett
Christopher Norbert Johnson
Nicholas John Palmer
Gianni Chessari
Steven Howard
Ildiko Maria Buck
Rhian Sara Holvey
James Edward Harvey Day
Hideto Fujiwara
Steven Douglas Hiscock
John Walter Liebeschuetz
Denis Jeffrey David St
David Geoffrey Twigg
Andrew James Woodhead
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1803439.7A external-priority patent/GB201803439D0/en
Priority claimed from GBGB1814135.8A external-priority patent/GB201814135D0/en
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of MX2020008754A publication Critical patent/MX2020008754A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención proporciona nuevos derivados de pirazina de fórmula (I): (ver formula) o un tautómero o un solvato o una sal farmacéuticamente aceptable de este, en donde los sustituyentes son como se definen en el presente documento. La invención también proporciona composiciones farmacéuticas que comprenden dichos compuestos y el uso de dichos compuestos en el tratamiento de enfermedades, p. ej., el cáncer.
MX2020008754A 2018-03-02 2019-03-01 Compuestos farmaceuticos. MX2020008754A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1803439.7A GB201803439D0 (en) 2018-03-02 2018-03-02 Pharmaceutical compounds
GBGB1814135.8A GB201814135D0 (en) 2018-08-30 2018-08-30 Pharmaceutical compounds
PCT/IB2019/051641 WO2019167000A1 (en) 2018-03-02 2019-03-01 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
MX2020008754A true MX2020008754A (es) 2020-12-07

Family

ID=65911230

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020008754A MX2020008754A (es) 2018-03-02 2019-03-01 Compuestos farmaceuticos.

Country Status (17)

Country Link
US (1) US11466016B2 (es)
EP (1) EP3759111A1 (es)
JP (1) JP7326305B2 (es)
KR (1) KR20200127005A (es)
CN (1) CN111902415A (es)
AU (1) AU2019226480B2 (es)
BR (1) BR112020017283A2 (es)
CA (1) CA3092011A1 (es)
IL (1) IL276232B2 (es)
MA (1) MA52421A (es)
MX (1) MX2020008754A (es)
NZ (1) NZ766835A (es)
PH (1) PH12020551305A1 (es)
SG (1) SG11202006778TA (es)
TW (1) TW202000667A (es)
WO (1) WO2019167000A1 (es)
ZA (1) ZA202004729B (es)

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Also Published As

Publication number Publication date
CA3092011A1 (en) 2019-09-06
KR20200127005A (ko) 2020-11-09
IL276232B1 (en) 2023-12-01
ZA202004729B (en) 2024-02-28
JP2021514962A (ja) 2021-06-17
TW202000667A (zh) 2020-01-01
RU2020130228A (ru) 2022-04-04
SG11202006778TA (en) 2020-08-28
MA52421A (fr) 2021-01-06
NZ766835A (en) 2023-09-29
IL276232A (en) 2020-09-30
WO2019167000A1 (en) 2019-09-06
US11466016B2 (en) 2022-10-11
PH12020551305A1 (en) 2021-10-25
AU2019226480A1 (en) 2020-08-27
US20210107908A1 (en) 2021-04-15
CN111902415A (zh) 2020-11-06
IL276232B2 (en) 2024-04-01
AU2019226480B2 (en) 2022-12-15
JP7326305B2 (ja) 2023-08-15
EP3759111A1 (en) 2021-01-06
BR112020017283A2 (pt) 2020-12-15

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