MA52421A - Composés pharmaceutiques - Google Patents

Composés pharmaceutiques

Info

Publication number
MA52421A
MA52421A MA052421A MA52421A MA52421A MA 52421 A MA52421 A MA 52421A MA 052421 A MA052421 A MA 052421A MA 52421 A MA52421 A MA 52421A MA 52421 A MA52421 A MA 52421A
Authority
MA
Morocco
Prior art keywords
pharmaceutical compounds
pharmaceutical
compounds
Prior art date
Application number
MA052421A
Other languages
English (en)
Inventor
Ildiko Maria Buck
Gianni Chessari
James Edward Harvey Day
Hideto Fujiwara
Christopher Charles Frederick Hamlett
Steven Douglas Hiscock
Rhian Sara Holvey
Steven Howard
Christopher Norbert Johnson
John Walter Liebeschuetz
Nicholas John Palmer
Denis Jeffrey David St
David Geoffrey Twigg
Andrew James Woodhead
Original Assignee
Otsuka Pharma Co Ltd
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1803439.7A external-priority patent/GB201803439D0/en
Priority claimed from GBGB1814135.8A external-priority patent/GB201814135D0/en
Application filed by Otsuka Pharma Co Ltd, Taiho Pharmaceutical Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of MA52421A publication Critical patent/MA52421A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA052421A 2018-03-02 2019-03-01 Composés pharmaceutiques MA52421A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1803439.7A GB201803439D0 (en) 2018-03-02 2018-03-02 Pharmaceutical compounds
GBGB1814135.8A GB201814135D0 (en) 2018-08-30 2018-08-30 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
MA52421A true MA52421A (fr) 2021-01-06

Family

ID=65911230

Family Applications (1)

Application Number Title Priority Date Filing Date
MA052421A MA52421A (fr) 2018-03-02 2019-03-01 Composés pharmaceutiques

Country Status (18)

Country Link
US (1) US11466016B2 (fr)
EP (1) EP3759111A1 (fr)
JP (1) JP7326305B2 (fr)
KR (1) KR20200127005A (fr)
CN (1) CN111902415A (fr)
AU (1) AU2019226480B2 (fr)
BR (1) BR112020017283A2 (fr)
CA (1) CA3092011A1 (fr)
IL (1) IL276232B2 (fr)
MA (1) MA52421A (fr)
MX (1) MX2020008754A (fr)
NZ (1) NZ766835A (fr)
PH (1) PH12020551305A1 (fr)
RU (1) RU2020130228A (fr)
SG (1) SG11202006778TA (fr)
TW (1) TW202000667A (fr)
WO (1) WO2019167000A1 (fr)
ZA (1) ZA202004729B (fr)

Families Citing this family (38)

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US11466017B2 (en) 2011-03-10 2022-10-11 Board Of Regents, The University Of Texas System Heterocyclic inhibitors of PTPN11
CN109475531B (zh) 2016-05-31 2021-08-17 得克萨斯州立大学董事会 Ptpn11的杂环抑制剂
KR20230109185A (ko) 2016-06-07 2023-07-19 자코바이오 파마슈티칼스 컴퍼니 리미티드 Shp2 억제제로서 유용한 신규한 헤테로환형 유도체
WO2018057884A1 (fr) 2016-09-22 2018-03-29 Relay Therapeutics, Inc. Inhibiteurs de phosphatase shp2 et leurs procédés d'utilisation
TW201819386A (zh) 2016-10-24 2018-06-01 美商傳達治療有限公司 Shp2磷酸酶抑制劑及其使用方法
JP6878615B2 (ja) 2017-03-23 2021-05-26 ジャコバイオ ファーマスーティカルズ カンパニー リミテッドJacobio Pharmaceuticals Co., Ltd. Shp2阻害剤として有用な新規な複素環式誘導体
EP3630770A1 (fr) 2017-05-26 2020-04-08 Relay Therapeutics, Inc. Dérivés de pyrazolo[3,4-b]pyrazine en tant qu'inhibiteurs de la phosphatase shp2
US11701354B2 (en) 2017-09-29 2023-07-18 D. E. Shaw Research, Llc Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors
CA3092011A1 (fr) 2018-03-02 2019-09-06 Otsuka Pharmaceutical Co., Ltd. Composes pharmaceutiques
TW202003471A (zh) 2018-03-21 2020-01-16 美商傳達治療有限公司 Shp2磷酸酶抑制劑及其使用方法
SG11202010822SA (en) 2018-05-02 2020-11-27 Navire Pharma Inc Substituted heterocyclic inhibitors of ptpn11
US20220363693A1 (en) * 2018-07-24 2022-11-17 Taiho Pharmaceutical Co., Ltd. Heterobicyclic compounds for inhibiting the activity of shp2
SG11202100199UA (en) 2018-08-10 2021-02-25 Navire Pharma Inc 6-(4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3h)-one derivatives and related compounds as ptpn11 (shp2) inhibitors for treating cancer
CA3113234A1 (fr) 2018-09-18 2020-03-26 Nikang Therapeutics, Inc. Derives heteroaryles tri-substitues utilises en tant qu'inhibiteurs de la phosphatase src a homologie-2
WO2020072656A1 (fr) 2018-10-03 2020-04-09 Gilead Sciences, Inc. Dérivés d'imidozopyrimidine
TW202116773A (zh) * 2019-07-04 2021-05-01 英屬開曼群島商百濟神州有限公司 作為HPK1抑制劑之吡咯并[2,3-b]吡及其用途
US20220402916A1 (en) 2019-09-18 2022-12-22 Merck Sharp & Dohme Corp. Small molecule inhibitors of kras g12c mutant
US11890281B2 (en) 2019-09-24 2024-02-06 Relay Therapeutics, Inc. SHP2 phosphatase inhibitors and methods of making and using the same
AU2020372881A1 (en) 2019-10-28 2022-06-09 Merck Sharp & Dohme Llc Small molecule inhibitors of KRAS G12C mutant
JP2023515235A (ja) 2019-10-31 2023-04-12 大鵬薬品工業株式会社 4-アミノブタ-2-エンアミド誘導体及びその塩
EP4055017A1 (fr) 2019-11-08 2022-09-14 Revolution Medicines, Inc. Composés hétéroaryles bicycliques et leurs utilisations
WO2021106231A1 (fr) 2019-11-29 2021-06-03 Taiho Pharmaceutical Co., Ltd. Composé ayant une activité inhibitrice contre la mutation kras g12d
WO2021215545A1 (fr) 2020-04-24 2021-10-28 Taiho Pharmaceutical Co., Ltd. Polythérapie anticancéreuse avec un inhibiteur de n-(1-acryloyl-azétidin-3-yl)-2-((1h-indazol-3-yl) amino) méthyl)-1 h-imidazole-5-carboxamide de kras-g12c
EP4139299A1 (fr) 2020-04-24 2023-03-01 Taiho Pharmaceutical Co., Ltd. Inhibiteurs de protéine kras g12d
WO2021257736A1 (fr) 2020-06-18 2021-12-23 Revolution Medicines, Inc. Méthodes de retardement, de prévention et de traitement de la résistance acquise aux inhibiteurs de ras
TW202216151A (zh) 2020-07-15 2022-05-01 日商大鵬藥品工業股份有限公司 含有使用於腫瘤之治療之嘧啶化合物之組合
IL301062A (en) 2020-09-03 2023-05-01 Revolution Medicines Inc Use of SOS1 inhibitors to treat malignancies with SHP2 mutations
PE20231207A1 (es) 2020-09-15 2023-08-17 Revolution Medicines Inc Derivados indolicos como inhibidores de ras en el tratamiento del cancer
WO2022232320A1 (fr) * 2021-04-27 2022-11-03 Merck Sharp & Dohme Corp. Inhibiteurs à petites molécules de mutant de kras g12c
WO2022235864A1 (fr) 2021-05-05 2022-11-10 Revolution Medicines, Inc. Inhibiteurs de ras
WO2022235870A1 (fr) 2021-05-05 2022-11-10 Revolution Medicines, Inc. Inhibiteurs de ras pour le traitement du cancer
CN117500811A (zh) 2021-05-05 2024-02-02 锐新医药公司 共价ras抑制剂及其用途
CN115340545A (zh) * 2021-05-14 2022-11-15 浙江海正药业股份有限公司 双环杂芳基类衍生物及其制备方法和用途
WO2022250170A1 (fr) 2021-05-28 2022-12-01 Taiho Pharmaceutical Co., Ltd. Petites molécules inhibitrices de protéines mutées par kras
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
WO2023168036A1 (fr) 2022-03-04 2023-09-07 Eli Lilly And Company Procédé de traitement comprenant des inhibiteurs de kras g12c et des inhibiteurs de shp2
WO2023172940A1 (fr) 2022-03-08 2023-09-14 Revolution Medicines, Inc. Méthodes de traitement du cancer du poumon réfractaire immunitaire
WO2023240263A1 (fr) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Inhibiteurs de ras macrocycliques

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CA2562244A1 (fr) 2004-04-07 2005-10-27 Takeda Pharmaceutical Company Limited Composes cycliques
JP2008520745A (ja) 2004-11-22 2008-06-19 バーテックス ファーマシューティカルズ インコーポレイテッド Rhoキナーゼの二環式阻害剤
CN102311447B (zh) 2010-07-07 2013-11-27 中国科学院广州生物医药与健康研究院 杂环并嘧啶酮类dpp-iv抑制剂
US9023865B2 (en) 2011-10-27 2015-05-05 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
CN105899493B (zh) 2014-01-17 2019-03-29 诺华股份有限公司 用于抑制shp2活性的1-(三嗪-3-基/哒嗪-3-基)-哌(-嗪)啶衍生物及其组合物
JO3517B1 (ar) 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
US10093646B2 (en) 2014-01-17 2018-10-09 Novartis Ag 1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
ES2741746T3 (es) * 2015-06-19 2020-02-12 Novartis Ag Compuestos y composiciones para inhibir la actividad de SHP2
EP3310774B1 (fr) 2015-06-19 2020-04-29 Novartis AG Composés et compositions pour l'inhibition de l'activité de shp2
EP3310771B1 (fr) 2015-06-19 2020-07-22 Novartis AG Composés et compositions pour l'inhibition de l'activité de shp2
SG11201710604SA (en) 2015-06-22 2018-01-30 Ono Pharmaceutical Co Brk inhibitory compound
WO2017156397A1 (fr) 2016-03-11 2017-09-14 Board Of Regents, The University Of Texas Sysytem Inhibiteurs hétérocycliques de ptpn11
CN109475531B (zh) 2016-05-31 2021-08-17 得克萨斯州立大学董事会 Ptpn11的杂环抑制剂
KR20230109185A (ko) 2016-06-07 2023-07-19 자코바이오 파마슈티칼스 컴퍼니 리미티드 Shp2 억제제로서 유용한 신규한 헤테로환형 유도체
WO2017216706A1 (fr) 2016-06-14 2017-12-21 Novartis Ag Composés et compositions pour l'inhibition de l'activité de shp2
WO2018057884A1 (fr) 2016-09-22 2018-03-29 Relay Therapeutics, Inc. Inhibiteurs de phosphatase shp2 et leurs procédés d'utilisation
TW201819386A (zh) 2016-10-24 2018-06-01 美商傳達治療有限公司 Shp2磷酸酶抑制劑及其使用方法
WO2018130928A1 (fr) 2017-01-10 2018-07-19 Novartis Ag Combinaison pharmaceutique comprenant un inhibiteur d'alk et un inhibiteur de shp2
GB201706327D0 (en) 2017-04-20 2017-06-07 Otsuka Pharma Co Ltd A pharmaceutical compound
EP3630770A1 (fr) 2017-05-26 2020-04-08 Relay Therapeutics, Inc. Dérivés de pyrazolo[3,4-b]pyrazine en tant qu'inhibiteurs de la phosphatase shp2
AU2018328273A1 (en) 2017-09-07 2020-03-12 Revolution Medicines, Inc. SHP2 inhibitor compositions and methods for treating cancer
SG11202004090YA (en) 2017-12-15 2020-05-28 Revolution Medicines Inc Polycyclic compounds as allosteric shp2 inhibitors
EP3755699A1 (fr) 2018-02-21 2020-12-30 Relay Therapeutics, Inc. Inhibiteurs de la protéine shp2 phosphatase et leurs procédés d'utilisation
CA3092011A1 (fr) 2018-03-02 2019-09-06 Otsuka Pharmaceutical Co., Ltd. Composes pharmaceutiques
EP3768680A1 (fr) 2018-03-21 2021-01-27 Relay Therapeutics, Inc. Inhibiteurs de la phosphatase pyrazolo[3,4-b]pyrazine shp2 et leurs procédés d'utilisation
AU2019239658A1 (en) 2018-03-21 2020-11-12 Suzhou Puhe BioPharma Co., Ltd. SHP2 inhibitors and uses thereof
SG11202010822SA (en) 2018-05-02 2020-11-27 Navire Pharma Inc Substituted heterocyclic inhibitors of ptpn11
US20220363693A1 (en) 2018-07-24 2022-11-17 Taiho Pharmaceutical Co., Ltd. Heterobicyclic compounds for inhibiting the activity of shp2
EP4282416A3 (fr) 2018-09-29 2024-03-06 Novartis AG Procédé de fabrication d'un composé pour inhiber l'activité de shp2
AU2019346118B2 (en) 2018-09-29 2024-05-16 Novartis Ag Manufacture of compounds and compositions for inhibiting the activity of SHP2
GB201911928D0 (en) 2019-08-20 2019-10-02 Otsuka Pharma Co Ltd Pharmaceutical compounds
EP4093406A4 (fr) 2020-01-24 2024-02-28 Taiho Pharmaceutical Co Ltd Amélioration de l'activité anti-tumorale de la pyrimidinone inhibitrice de shp2 en association avec de nouveaux médicaments anti-cancéreux contre le cancer

Also Published As

Publication number Publication date
NZ766835A (en) 2023-09-29
SG11202006778TA (en) 2020-08-28
TW202000667A (zh) 2020-01-01
KR20200127005A (ko) 2020-11-09
ZA202004729B (en) 2024-02-28
JP2021514962A (ja) 2021-06-17
AU2019226480B2 (en) 2022-12-15
JP7326305B2 (ja) 2023-08-15
CA3092011A1 (fr) 2019-09-06
IL276232A (en) 2020-09-30
PH12020551305A1 (en) 2021-10-25
BR112020017283A2 (pt) 2020-12-15
WO2019167000A1 (fr) 2019-09-06
IL276232B2 (en) 2024-04-01
US20210107908A1 (en) 2021-04-15
CN111902415A (zh) 2020-11-06
MX2020008754A (es) 2020-12-07
IL276232B1 (en) 2023-12-01
US11466016B2 (en) 2022-10-11
AU2019226480A1 (en) 2020-08-27
RU2020130228A (ru) 2022-04-04
EP3759111A1 (fr) 2021-01-06

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