MA52421A - Composés pharmaceutiques - Google Patents
Composés pharmaceutiquesInfo
- Publication number
- MA52421A MA52421A MA052421A MA52421A MA52421A MA 52421 A MA52421 A MA 52421A MA 052421 A MA052421 A MA 052421A MA 52421 A MA52421 A MA 52421A MA 52421 A MA52421 A MA 52421A
- Authority
- MA
- Morocco
- Prior art keywords
- pharmaceutical compounds
- pharmaceutical
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1803439.7A GB201803439D0 (en) | 2018-03-02 | 2018-03-02 | Pharmaceutical compounds |
| GBGB1814135.8A GB201814135D0 (en) | 2018-08-30 | 2018-08-30 | Pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA52421A true MA52421A (fr) | 2021-01-06 |
Family
ID=65911230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA052421A MA52421A (fr) | 2018-03-02 | 2019-03-01 | Composés pharmaceutiques |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11466016B2 (fr) |
| EP (1) | EP3759111A1 (fr) |
| JP (1) | JP7326305B2 (fr) |
| KR (1) | KR20200127005A (fr) |
| CN (1) | CN111902415A (fr) |
| AU (1) | AU2019226480B2 (fr) |
| BR (1) | BR112020017283A2 (fr) |
| CA (1) | CA3092011A1 (fr) |
| IL (1) | IL276232B2 (fr) |
| MA (1) | MA52421A (fr) |
| MX (1) | MX2020008754A (fr) |
| NZ (1) | NZ766835A (fr) |
| PH (1) | PH12020551305A1 (fr) |
| SG (1) | SG11202006778TA (fr) |
| TW (1) | TW202000667A (fr) |
| WO (1) | WO2019167000A1 (fr) |
| ZA (1) | ZA202004729B (fr) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11466017B2 (en) | 2011-03-10 | 2022-10-11 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| JP7044375B2 (ja) | 2016-05-31 | 2022-03-30 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｐｔｐｎ１１の複素環式阻害剤 |
| CN112250670B (zh) | 2016-06-07 | 2021-06-08 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| US11529347B2 (en) | 2016-09-22 | 2022-12-20 | Relay Therapeutics, Inc. | SHP2 phosphatase inhibitors and methods of use thereof |
| WO2018081091A1 (fr) | 2016-10-24 | 2018-05-03 | Relay Therapeutics, Inc. | Dérivés de pyrazolo [3,4-b] pyrazine en tant qu'inhibiteurs de la phosphatase shp2 |
| SG11201908820VA (en) | 2017-03-23 | 2019-10-30 | Jacobio Pharmaceuticals Co Ltd | Novel heterocyclic derivatives useful as shp2 inhibitors |
| EP3630770A1 (fr) | 2017-05-26 | 2020-04-08 | Relay Therapeutics, Inc. | Dérivés de pyrazolo[3,4-b]pyrazine en tant qu'inhibiteurs de la phosphatase shp2 |
| EP3687997A1 (fr) | 2017-09-29 | 2020-08-05 | Relay Therapeutics, Inc. | Dérivés de pyrazolo[3,4-b]pyrazine utilisés en tant qu'inhibiteurs de la phosphatase shp2 |
| CN111902415A (zh) | 2018-03-02 | 2020-11-06 | 大冢制药株式会社 | 药学化合物 |
| CA3094690A1 (fr) | 2018-03-21 | 2019-09-26 | Relay Therapeutics, Inc. | Inhibiteurs de la phosphatase shp2 et leurs procedes d'utilisation |
| EP3787627A4 (fr) | 2018-05-02 | 2021-12-01 | Navire Pharma, Inc. | Inhibiteurs hétérocycliques substitués de ptpn11 |
| MX2021000795A (es) * | 2018-07-24 | 2021-04-12 | Taiho Pharmaceutical Co Ltd | Compuestos heterociclicos para inhibir la actividad de shp2. |
| CA3109181A1 (fr) | 2018-08-10 | 2020-02-13 | Navire Pharma, Inc. | Derives de 6-(4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3h)-one et composes apparentes en tant qu'inhibiteurs de ptpn11 (shp2) p our le traitement du cancer |
| EP3853234A1 (fr) | 2018-09-18 | 2021-07-28 | Nikang Therapeutics, Inc. | Dérivés d'anneaux tricycliques fusionnés utilisés en tant qu'inhibiteurs de la phosphatase src à homologie-2 |
| WO2020072656A1 (fr) | 2018-10-03 | 2020-04-09 | Gilead Sciences, Inc. | Dérivés d'imidozopyrimidine |
| AU2020299892A1 (en) * | 2019-07-04 | 2022-01-27 | Beigene, Ltd. | Pyrrolo [2, 3-b] pyrazines as HPK1 inhibitor and the use thereof |
| US20220402916A1 (en) | 2019-09-18 | 2022-12-22 | Merck Sharp & Dohme Corp. | Small molecule inhibitors of kras g12c mutant |
| BR112022005349A2 (pt) | 2019-09-24 | 2022-06-14 | Relay Therapeutics Inc | Inibidores de shp2 fosfatase e métodos de produção e uso dos mesmos |
| AU2020372881A1 (en) | 2019-10-28 | 2022-06-09 | Merck Sharp & Dohme Llc | Small molecule inhibitors of KRAS G12C mutant |
| US20230023023A1 (en) | 2019-10-31 | 2023-01-26 | Taiho Pharmaceutical Co., Ltd. | 4-aminobut-2-enamide derivatives and salts thereof |
| BR112022008858A2 (pt) | 2019-11-08 | 2022-09-06 | Revolution Medicines Inc | Composto, composição farmacêutica e métodos para inibir sos1 em um sujeito, para inibir a interação de sos1 e uma proteína, para tratar ou prevenir uma doença e para tratar ou prevenir câncer |
| WO2021106231A1 (fr) | 2019-11-29 | 2021-06-03 | Taiho Pharmaceutical Co., Ltd. | Composé ayant une activité inhibitrice contre la mutation kras g12d |
| US20230174518A1 (en) | 2020-04-24 | 2023-06-08 | Taiho Pharmaceutical Co., Ltd. | Kras g12d protein inhibitors |
| US20230181536A1 (en) | 2020-04-24 | 2023-06-15 | Taiho Pharmaceutical Co., Ltd. | Anticancer combination therapy with n-(1-acryloyl-azetidin-3-yl)-2-((1h-indazol-3-yl)amino)methyl)-1h-imidazole-5-carboxamide inhibitor of kras-g12c |
| KR20230042600A (ko) | 2020-06-18 | 2023-03-28 | 레볼루션 메디슨즈, 인크. | Ras 억제제에 대한 획득된 저항성을 지연, 예방, 및 치료하는 방법 |
| WO2022014640A1 (fr) | 2020-07-15 | 2022-01-20 | 大鵬薬品工業株式会社 | Combinaison contenant un composé pyrimidine destinée à être utilisée dans le traitement de tumeurs |
| KR20230081726A (ko) | 2020-09-03 | 2023-06-07 | 레볼루션 메디슨즈, 인크. | Shp2 돌연변이가 있는 악성 종양을 치료하기 위한 sos1 억제제의 용도 |
| JP2023541916A (ja) | 2020-09-15 | 2023-10-04 | レボリューション メディシンズ インコーポレイテッド | がんの治療における、ｒａｓ阻害剤としてのインドール誘導体 |
| EP4329750A1 (fr) * | 2021-04-27 | 2024-03-06 | Merck Sharp & Dohme LLC | Inhibiteurs à petites molécules de mutant de kras g12c |
| CN117500811A (zh) | 2021-05-05 | 2024-02-02 | 锐新医药公司 | 共价ras抑制剂及其用途 |
| PE20240089A1 (es) | 2021-05-05 | 2024-01-16 | Revolution Medicines Inc | Inhibidores de ras para el tratamiento del cancer |
| EP4334321A1 (fr) | 2021-05-05 | 2024-03-13 | Revolution Medicines, Inc. | Inhibiteurs de ras |
| CN115340545A (zh) * | 2021-05-14 | 2022-11-15 | 浙江海正药业股份有限公司 | 双环杂芳基类衍生物及其制备方法和用途 |
| CN117769554A (zh) | 2021-05-28 | 2024-03-26 | 大鹏药品工业株式会社 | Kras突变蛋白的小分子抑制剂 |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| WO2023168036A1 (fr) | 2022-03-04 | 2023-09-07 | Eli Lilly And Company | Procédé de traitement comprenant des inhibiteurs de kras g12c et des inhibiteurs de shp2 |
| WO2023172940A1 (fr) | 2022-03-08 | 2023-09-14 | Revolution Medicines, Inc. | Méthodes de traitement du cancer du poumon réfractaire immunitaire |
| WO2023240263A1 (fr) | 2022-06-10 | 2023-12-14 | Revolution Medicines, Inc. | Inhibiteurs de ras macrocycliques |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1732541A4 (fr) | 2004-04-07 | 2008-03-05 | Takeda Pharmaceutical | Composes cycliques |
| EP2316835A1 (fr) | 2004-11-22 | 2011-05-04 | Vertex Pharmceuticals Incorporated | Pyrrolopyrazines et pyrazolopyrazines utilisable comme inhibiteurs de proteines-kinases |
| CN102311447B (zh) | 2010-07-07 | 2013-11-27 | 中国科学院广州生物医药与健康研究院 | 杂环并嘧啶酮类dpp-iv抑制剂 |
| WO2013063214A1 (fr) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Nouveaux composés qui sont des inhibiteurs d'erk |
| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| EP3094627B1 (fr) | 2014-01-17 | 2018-08-22 | Novartis AG | Dérivés de 1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine et compositions les contenant pour l'inhibition de l'activité de shp2 |
| EP3094629B1 (fr) | 2014-01-17 | 2018-08-22 | Novartis AG | Dérivés de 1-(triazin-3-yl/pyridazin-3-yl)-piper(-azine)idine et compositions les contenant pour l'inhibition de l'activité de shp2 |
| EP3310779B1 (fr) * | 2015-06-19 | 2019-05-08 | Novartis AG | Composés et compositions pour l'inhibition de l'activité de shp2 |
| ES2805232T3 (es) | 2015-06-19 | 2021-02-11 | Novartis Ag | Compuestos y composiciones para inhibir la actividad de SHP2 |
| JP6878316B2 (ja) | 2015-06-19 | 2021-05-26 | ノバルティス アーゲー | Ｓｈｐ２の活性を阻害するための化合物および組成物 |
| AU2016284402B2 (en) | 2015-06-22 | 2020-04-02 | Ono Pharmaceutical Co., Ltd. | Brk inhibitory compound |
| WO2017156397A1 (fr) | 2016-03-11 | 2017-09-14 | Board Of Regents, The University Of Texas Sysytem | Inhibiteurs hétérocycliques de ptpn11 |
| JP7044375B2 (ja) * | 2016-05-31 | 2022-03-30 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｐｔｐｎ１１の複素環式阻害剤 |
| CN112250670B (zh) | 2016-06-07 | 2021-06-08 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| PL3468972T3 (pl) | 2016-06-14 | 2020-11-16 | Novartis Ag | Związki i kompozycje do hamowania aktywności shp2 |
| US11529347B2 (en) | 2016-09-22 | 2022-12-20 | Relay Therapeutics, Inc. | SHP2 phosphatase inhibitors and methods of use thereof |
| WO2018081091A1 (fr) | 2016-10-24 | 2018-05-03 | Relay Therapeutics, Inc. | Dérivés de pyrazolo [3,4-b] pyrazine en tant qu'inhibiteurs de la phosphatase shp2 |
| KR102571130B1 (ko) | 2017-01-10 | 2023-08-28 | 노파르티스 아게 | Alk 저해제 및 shp2 저해제를 포함하는 약제학적 조합 |
| GB201706327D0 (en) | 2017-04-20 | 2017-06-07 | Otsuka Pharma Co Ltd | A pharmaceutical compound |
| EP3630770A1 (fr) | 2017-05-26 | 2020-04-08 | Relay Therapeutics, Inc. | Dérivés de pyrazolo[3,4-b]pyrazine en tant qu'inhibiteurs de la phosphatase shp2 |
| KR20200051684A (ko) | 2017-09-07 | 2020-05-13 | 레볼루션 메디슨즈, 인크. | 암 치료를 위한 shp2 억제제 조성물 및 방법 |
| MX2020006273A (es) | 2017-12-15 | 2020-09-14 | Revolution Medicines Inc | Compuestos policiclicos como inhibidores alostericos de shp2. |
| WO2019165073A1 (fr) | 2018-02-21 | 2019-08-29 | Relay Therapeutics, Inc. | Inhibiteurs de la protéine shp2 phosphatase et leurs procédés d'utilisation |
| CN111902415A (zh) | 2018-03-02 | 2020-11-06 | 大冢制药株式会社 | 药学化合物 |
| JP7265275B2 (ja) | 2018-03-21 | 2023-04-26 | スージョウ プーヘー バイオファーマ カンパニー リミテッド | Ｓｈｐ２阻害剤およびその使用 |
| EP3768680A1 (fr) | 2018-03-21 | 2021-01-27 | Relay Therapeutics, Inc. | Inhibiteurs de la phosphatase pyrazolo[3,4-b]pyrazine shp2 et leurs procédés d'utilisation |
| EP3787627A4 (fr) | 2018-05-02 | 2021-12-01 | Navire Pharma, Inc. | Inhibiteurs hétérocycliques substitués de ptpn11 |
| MX2021000795A (es) | 2018-07-24 | 2021-04-12 | Taiho Pharmaceutical Co Ltd | Compuestos heterociclicos para inhibir la actividad de shp2. |
| IL305106A (en) | 2018-09-29 | 2023-10-01 | Novartis Ag | A process for producing a compound to inhibit the activity of SHP2 |
| CN112867718A (zh) | 2018-09-29 | 2021-05-28 | 诺华股份有限公司 | 用于抑制shp2活性的化合物和组合物的制造 |
| GB201911928D0 (en) | 2019-08-20 | 2019-10-02 | Otsuka Pharma Co Ltd | Pharmaceutical compounds |
| WO2021149817A1 (fr) | 2020-01-24 | 2021-07-29 | Taiho Pharmaceutical Co., Ltd. | Amélioration de l'activité anti-tumorale de la pyrimidinone inhibitrice de shp2 en association avec de nouveaux médicaments anti-cancéreux contre le cancer |
-
2019
- 2019-03-01 CN CN201980022127.4A patent/CN111902415A/zh active Pending
- 2019-03-01 US US16/976,631 patent/US11466016B2/en active Active
- 2019-03-01 MA MA052421A patent/MA52421A/fr unknown
- 2019-03-01 AU AU2019226480A patent/AU2019226480B2/en active Active
- 2019-03-01 SG SG11202006778TA patent/SG11202006778TA/en unknown
- 2019-03-01 BR BR112020017283-9A patent/BR112020017283A2/pt unknown
- 2019-03-01 EP EP19713584.1A patent/EP3759111A1/fr active Pending
- 2019-03-01 MX MX2020008754A patent/MX2020008754A/es unknown
- 2019-03-01 NZ NZ766835A patent/NZ766835A/en unknown
- 2019-03-01 WO PCT/IB2019/051641 patent/WO2019167000A1/fr active Application Filing
- 2019-03-01 IL IL276232A patent/IL276232B2/en unknown
- 2019-03-01 KR KR1020207027598A patent/KR20200127005A/ko not_active Application Discontinuation
- 2019-03-01 JP JP2020544607A patent/JP7326305B2/ja active Active
- 2019-03-01 CA CA3092011A patent/CA3092011A1/fr active Pending
- 2019-03-04 TW TW108107099A patent/TW202000667A/zh unknown
-
2020
- 2020-07-30 ZA ZA2020/04729A patent/ZA202004729B/en unknown
- 2020-08-13 PH PH12020551305A patent/PH12020551305A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP7326305B2 (ja) | 2023-08-15 |
| US11466016B2 (en) | 2022-10-11 |
| BR112020017283A2 (pt) | 2020-12-15 |
| JP2021514962A (ja) | 2021-06-17 |
| EP3759111A1 (fr) | 2021-01-06 |
| CN111902415A (zh) | 2020-11-06 |
| IL276232B2 (en) | 2024-04-01 |
| RU2020130228A (ru) | 2022-04-04 |
| ZA202004729B (en) | 2024-02-28 |
| TW202000667A (zh) | 2020-01-01 |
| MX2020008754A (es) | 2020-12-07 |
| AU2019226480A1 (en) | 2020-08-27 |
| IL276232A (en) | 2020-09-30 |
| WO2019167000A1 (fr) | 2019-09-06 |
| IL276232B1 (en) | 2023-12-01 |
| KR20200127005A (ko) | 2020-11-09 |
| AU2019226480B2 (en) | 2022-12-15 |
| SG11202006778TA (en) | 2020-08-28 |
| NZ766835A (en) | 2023-09-29 |
| PH12020551305A1 (en) | 2021-10-25 |
| CA3092011A1 (fr) | 2019-09-06 |
| US20210107908A1 (en) | 2021-04-15 |
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| DK3886820T3 (da) | Kapselformuleringer | |
| MA54095A (fr) | Formulations pharmaceutiques aqueuses | |
| DK3996688T3 (da) | Farmaceutisk præparat |