|
WO2006088246A1
(ja)
*
|
2005-02-18 |
2006-08-24 |
Takeda Pharmaceutical Company Limited |
Gpr34受容体機能調節剤
|
|
CA2662242C
(en)
*
|
2006-09-07 |
2012-06-12 |
Amgen Inc. |
Benzo-fused compounds for use in treating metabolic disorders
|
|
EP2064193A1
(en)
*
|
2006-09-07 |
2009-06-03 |
Amgen, Inc |
Heterocyclic gpr40 modulators
|
|
AU2008241490B2
(en)
*
|
2007-04-16 |
2011-07-21 |
Amgen Inc. |
Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid GPR40 modulators
|
|
EP2025674A1
(de)
|
2007-08-15 |
2009-02-18 |
sanofi-aventis |
Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
US8030354B2
(en)
|
2007-10-10 |
2011-10-04 |
Amgen Inc. |
Substituted biphenyl GPR40 modulators
|
|
EP2215068B1
(en)
*
|
2007-10-29 |
2012-06-13 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
WO2009111056A1
(en)
*
|
2008-03-06 |
2009-09-11 |
Amgen Inc. |
Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
|
|
US8580841B2
(en)
*
|
2008-07-23 |
2013-11-12 |
Arena Pharmaceuticals, Inc. |
Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
|
|
JP2012503595A
(ja)
*
|
2008-07-28 |
2012-02-09 |
シダンスク ユニバーシティ |
代謝病の治療用の化合物
|
|
HRP20160890T1
(hr)
*
|
2008-08-27 |
2016-09-23 |
Arena Pharmaceuticals, Inc. |
Derivati supstituirane tricikličke kiseline kao agonisti s1p1-receptora korisni u liječenju autoimunih i upalnih poremećaja
|
|
AU2009303475B2
(en)
*
|
2008-10-15 |
2012-09-13 |
Amgen Inc. |
Spirocyclic GPR40 modulators
|
|
EA022417B1
(ru)
*
|
2008-10-21 |
2015-12-30 |
Саймабэй Терапевтикс, Инк. |
Арильные агонисты рецептора gpr120 и их применение
|
|
AR074760A1
(es)
*
|
2008-12-18 |
2011-02-09 |
Metabolex Inc |
Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
|
|
WO2010085525A1
(en)
*
|
2009-01-23 |
2010-07-29 |
Schering Corporation |
Bridged and fused heterocyclic antidiabetic compounds
|
|
CN102421739A
(zh)
*
|
2009-04-22 |
2012-04-18 |
安斯泰来制药株式会社 |
羧酸化合物
|
|
JP5856980B2
(ja)
|
2010-01-27 |
2016-02-10 |
アリーナ ファーマシューティカルズ, インコーポレイテッド |
(R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス
|
|
WO2011107494A1
(de)
|
2010-03-03 |
2011-09-09 |
Sanofi |
Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
CN105503882B
(zh)
|
2010-03-03 |
2019-07-05 |
艾尼纳制药公司 |
制备s1p1受体调节剂及其晶体形式的方法
|
|
ES2526124T3
(es)
*
|
2010-06-16 |
2015-01-07 |
Cymabay Therapeutics, Inc. |
Agonistas del receptor GPR120 y sus usos
|
|
EP2582709B1
(de)
|
2010-06-18 |
2018-01-24 |
Sanofi |
Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
|
|
US8530413B2
(en)
|
2010-06-21 |
2013-09-10 |
Sanofi |
Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
|
|
TW201215387A
(en)
|
2010-07-05 |
2012-04-16 |
Sanofi Aventis |
Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
|
|
TW201221505A
(en)
|
2010-07-05 |
2012-06-01 |
Sanofi Sa |
Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
|
|
TW201215388A
(en)
|
2010-07-05 |
2012-04-16 |
Sanofi Sa |
(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
|
|
EP2683699B1
(de)
|
2011-03-08 |
2015-06-24 |
Sanofi |
Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
WO2012120056A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
EP2683704B1
(de)
|
2011-03-08 |
2014-12-17 |
Sanofi |
Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
US8828994B2
(en)
|
2011-03-08 |
2014-09-09 |
Sanofi |
Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
|
|
EP2766349B1
(de)
|
2011-03-08 |
2016-06-01 |
Sanofi |
Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
EP2511273B8
(en)
*
|
2011-04-15 |
2019-06-26 |
Hivih |
Inhibitors of viral replication, their process of preparation and their therapeutical uses
|
|
WO2013037390A1
(en)
|
2011-09-12 |
2013-03-21 |
Sanofi |
6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
|
|
WO2013045413A1
(en)
|
2011-09-27 |
2013-04-04 |
Sanofi |
6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
|
|
CN103429581B
(zh)
*
|
2012-01-12 |
2015-08-26 |
江苏恒瑞医药股份有限公司 |
多环类衍生物、其制备方法及其在医药上的应用
|
|
SI2841437T1
(sl)
|
2012-04-26 |
2017-09-29 |
Bristol-Myers Squibb Company |
Derivati imidazotiadiazola in imidazopirazina kot proteazno aktivirani receptor 4 (PAR4) inhibitorji za zdravljenje agregacije trombocitov
|
|
EP2855489B1
(en)
|
2012-04-26 |
2017-01-04 |
Bristol-Myers Squibb Company |
Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation
|
|
SG11201406759YA
(en)
|
2012-04-26 |
2014-11-27 |
Bristol Myers Squibb Co |
Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation
|
|
RU2015106909A
(ru)
|
2012-08-02 |
2016-09-27 |
Мерк Шарп И Доум Корп. |
Антидиабетические трициклические соединения
|
|
US20150297573A1
(en)
|
2012-10-24 |
2015-10-22 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING Beta-CELL SURVIVAL
|
|
RS55363B1
(sr)
|
2012-11-16 |
2017-03-31 |
Bristol Myers Squibb Co |
Dihidropirazolni gpr40 modulatori
|
|
JP6314335B2
(ja)
*
|
2013-02-06 |
2018-04-25 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
新しいインダニルオキシジヒドロベンゾフラニル酢酸
|
|
KR20150118158A
(ko)
|
2013-02-22 |
2015-10-21 |
머크 샤프 앤드 돔 코포레이션 |
항당뇨병 비시클릭 화합물
|
|
EP2963027B1
(en)
*
|
2013-02-28 |
2018-12-26 |
TiumBio Co., Ltd. |
Tricyclic compound and use thereof
|
|
CN104109115B
(zh)
*
|
2013-04-16 |
2016-11-23 |
中国科学院上海药物研究所 |
一种含氮杂环链接的苯丙酸类化合物、其药物组合物、制备方法和用途
|
|
EP2821104A1
(en)
|
2013-07-05 |
2015-01-07 |
Laboratoire Biodim |
Inhibitors of viral replication, their process of preparation and their therapeutical uses
|
|
CN105246875A
(zh)
*
|
2013-09-03 |
2016-01-13 |
四川海思科制药有限公司 |
茚满衍生物及其制备方法和在医药上的应用
|
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
EP3068768B1
(en)
*
|
2013-11-15 |
2019-07-31 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
EP3076959B1
(en)
|
2013-12-04 |
2018-07-04 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
|
WO2015089809A1
(en)
|
2013-12-19 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Antidiabetic substituted heteroaryl compounds
|
|
WO2015119899A1
(en)
|
2014-02-06 |
2015-08-13 |
Merck Sharp & Dohme Corp. |
Antidiabetic compounds
|
|
WO2015176267A1
(en)
|
2014-05-22 |
2015-11-26 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
US10662171B2
(en)
|
2014-08-08 |
2020-05-26 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
|
WO2016019587A1
(en)
|
2014-08-08 |
2016-02-11 |
Merck Sharp & Dohme Corp. |
[7, 6]-fused bicyclic antidiabetic compounds
|
|
WO2016022742A1
(en)
|
2014-08-08 |
2016-02-11 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
|
WO2016022446A1
(en)
|
2014-08-08 |
2016-02-11 |
Merck Sharp & Dohme Corp. |
[5,6]-fused bicyclic antidiabetic compounds
|
|
PL3242666T3
(pl)
|
2015-01-06 |
2025-02-17 |
Arena Pharmaceuticals, Inc. |
Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1
|
|
US10426818B2
(en)
|
2015-03-24 |
2019-10-01 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Method and pharmaceutical composition for use in the treatment of diabetes
|
|
BR112017027656B1
(pt)
|
2015-06-22 |
2023-12-05 |
Arena Pharmaceuticals, Inc. |
Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo
|
|
RS63319B1
(sr)
|
2015-09-02 |
2022-07-29 |
Trevena Inc |
Jedinjenja koja modulišu delta-opioidni receptor, koja sadrže 6-člani aza-heterociklik, postupci njihove upotrebe i spravljanja
|
|
US10676458B2
(en)
|
2016-03-29 |
2020-06-09 |
Merch Sharp & Dohne Corp. Rahway |
Antidiabetic bicyclic compounds
|
|
WO2017202275A1
(zh)
|
2016-05-23 |
2017-11-30 |
中国医学科学院药物研究所 |
溴代苄醚衍生物、及其制法和药物组合物与用途
|
|
US11072602B2
(en)
|
2016-12-06 |
2021-07-27 |
Merck Sharp & Dohme Corp. |
Antidiabetic heterocyclic compounds
|
|
EP3558298B1
(en)
|
2016-12-20 |
2026-03-11 |
Merck Sharp & Dohme LLC |
Antidiabetic spirochroman compounds
|
|
MX2019009843A
(es)
|
2017-02-16 |
2020-01-30 |
Arena Pharm Inc |
Compuestos y metodos para el tratamiento de la enfermedad inflamatoria intestinal con manifestaciones extraintestinales.
|
|
MX2019009841A
(es)
|
2017-02-16 |
2020-01-30 |
Arena Pharm Inc |
Compuestos y metodos para el tratamiento de la colangitis biliar primaria.
|
|
CN110446495B
(zh)
|
2017-02-17 |
2023-09-05 |
特维娜有限公司 |
含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法
|
|
AU2018221148B2
(en)
|
2017-02-17 |
2022-05-05 |
Trevena, Inc. |
5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
|
|
AR111199A1
(es)
*
|
2017-03-31 |
2019-06-12 |
Takeda Pharmaceuticals Co |
Compuesto aromático agonista de gpr40
|
|
BR102018007822A2
(pt)
|
2017-04-20 |
2018-11-06 |
Gilead Sciences, Inc. |
composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
|
|
CN109320483A
(zh)
*
|
2017-08-01 |
2019-02-12 |
南京大学 |
香豆素衍生物、其制备方法及其作为药物的用途
|
|
RU2764243C2
(ru)
|
2017-09-22 |
2022-01-14 |
ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи |
Гетероциклические соединения в качестве ингибиторов PAD
|
|
AU2018352142B2
(en)
|
2017-10-18 |
2022-08-25 |
Jubilant Epipad LLC |
Imidazo-pyridine compounds as PAD inhibitors
|
|
US11629135B2
(en)
|
2017-11-06 |
2023-04-18 |
Jubilant Prodell Llc |
Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
|
|
US11225471B2
(en)
|
2017-11-16 |
2022-01-18 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
|
PT3704120T
(pt)
|
2017-11-24 |
2024-07-03 |
Jubilant Episcribe Llc |
Compostos heterocíclicos como inibidores de prmt5
|
|
CR20200347A
(es)
|
2018-02-13 |
2020-09-23 |
Gilead Sciences Inc |
Inhibidores pd-1/pd-l1
|
|
MX2020009517A
(es)
|
2018-03-13 |
2021-01-20 |
Jubilant Prodel LLC |
Compuestos biciclicos como inhibidores de la interaccion/activacio n de pdl/pd-l1.
|
|
TWI712412B
(zh)
|
2018-04-19 |
2020-12-11 |
美商基利科學股份有限公司 |
Pd‐1/pd‐l1抑制劑
|
|
CA3102136A1
(en)
|
2018-06-06 |
2019-12-12 |
Arena Pharmaceuticals, Inc. |
Methods of treating conditions related to the s1p1 receptor
|
|
SG11202012425QA
(en)
|
2018-07-13 |
2021-01-28 |
Gilead Sciences Inc |
Pd-1/pd-l1 inhibitors
|
|
CN112955431A
(zh)
|
2018-09-06 |
2021-06-11 |
艾尼纳制药公司 |
可用于治疗自身免疫性病症和炎性病症的化合物
|
|
WO2020086556A1
(en)
|
2018-10-24 |
2020-04-30 |
Gilead Sciences, Inc. |
Pd-1/pd-l1 inhibitors
|
|
WO2020114475A1
(zh)
*
|
2018-12-06 |
2020-06-11 |
上海济煜医药科技有限公司 |
作为免疫调节的芳环衍生物及其制备方法和应用
|
|
CN110156761B
(zh)
*
|
2019-06-18 |
2022-08-09 |
郑州大学 |
含香豆素-联苯骨架化合物、制备方法及其应用
|
|
CN113880747B
(zh)
*
|
2020-07-03 |
2023-05-26 |
上海美迪西生物医药股份有限公司 |
一种吲哚衍生物及其应用
|
|
CN114163426B
(zh)
|
2020-09-10 |
2024-03-19 |
上海爱博医药科技有限公司 |
苯并含氧杂环类化合物及其医药应用
|
|
CN115340484A
(zh)
*
|
2021-05-13 |
2022-11-15 |
上海美迪西生物医药股份有限公司 |
苄氧基吲哚类支链酸类衍生物及其制备方法和应用
|
|
EP4556465A4
(en)
*
|
2022-11-22 |
2025-10-29 |
Xian Xintong Pharmaceutical Res Co Ltd |
NEW BICYCLIC PD-L1 INHIBITORS, THEIR PREPARATION PROCESSES AND MEDICINAL USES
|
|
CN116283560A
(zh)
*
|
2023-02-27 |
2023-06-23 |
南通大学 |
一种基于水溶性柱芳烃的纳米诊疗材料
|
|
WO2025141118A1
(en)
*
|
2023-12-27 |
2025-07-03 |
Institut National de la Santé et de la Recherche Médicale |
Arylalkyloxyindole compounds and derivatives and their use
|