JP2009529544A5 - - Google Patents
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- Publication number
- JP2009529544A5 JP2009529544A5 JP2008558611A JP2008558611A JP2009529544A5 JP 2009529544 A5 JP2009529544 A5 JP 2009529544A5 JP 2008558611 A JP2008558611 A JP 2008558611A JP 2008558611 A JP2008558611 A JP 2008558611A JP 2009529544 A5 JP2009529544 A5 JP 2009529544A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- optionally substituted
- substituents
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78252306P | 2006-03-16 | 2006-03-16 | |
| US60/782,523 | 2006-03-16 | ||
| US87699406P | 2006-12-26 | 2006-12-26 | |
| US60/876,994 | 2006-12-26 | ||
| PCT/CA2007/000428 WO2007104162A1 (en) | 2006-03-16 | 2007-03-16 | Iap bir domain binding compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009529544A JP2009529544A (ja) | 2009-08-20 |
| JP2009529544A5 true JP2009529544A5 (https=) | 2010-04-30 |
| JP5419468B2 JP5419468B2 (ja) | 2014-02-19 |
Family
ID=38509005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008558611A Expired - Fee Related JP5419468B2 (ja) | 2006-03-16 | 2007-03-16 | Iapのbirドメインに結合する化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US7579320B2 (https=) |
| EP (1) | EP2004600A4 (https=) |
| JP (1) | JP5419468B2 (https=) |
| KR (1) | KR101446907B1 (https=) |
| AU (1) | AU2007224932B2 (https=) |
| BR (1) | BRPI0709610A2 (https=) |
| CA (1) | CA2581960C (https=) |
| IL (1) | IL193951A (https=) |
| MX (1) | MX2008011837A (https=) |
| NO (1) | NO20083868L (https=) |
| NZ (1) | NZ571577A (https=) |
| PH (1) | PH12014502420B1 (https=) |
| SG (1) | SG170739A1 (https=) |
| TW (2) | TWI504597B (https=) |
| WO (1) | WO2007104162A1 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005274937B2 (en) | 2004-07-15 | 2011-08-18 | Medivir Ab | IAP binding compounds |
| MX2007007195A (es) | 2004-12-20 | 2007-10-08 | Genentech Inc | Inhibidores de pirrolidina de iap. |
| ES2456671T3 (es) | 2005-02-25 | 2014-04-23 | Tetralogic Pharmaceuticals Corporation | Inhibidores diméricos de IAP |
| US7772177B2 (en) * | 2005-05-18 | 2010-08-10 | Aegera Therapeutics, Inc. | BIR domain binding compounds |
| US20100256046A1 (en) * | 2009-04-03 | 2010-10-07 | Tetralogic Pharmaceuticals Corporation | Treatment of proliferative disorders |
| WO2007048224A1 (en) | 2005-10-25 | 2007-05-03 | Aegera Therapeutics Inc. | Iap bir domain binding compounds |
| WO2007106192A2 (en) | 2005-12-19 | 2007-09-20 | Genentech, Inc. | Inhibitors of iap |
| TWI504597B (zh) | 2006-03-16 | 2015-10-21 | Pharmascience Inc | 結合於細胞凋亡抑制蛋白(iap)之桿狀病毒iap重複序列(bir)區域之化合物 |
| BRPI0708942A2 (pt) * | 2006-03-21 | 2011-06-14 | Joyant Pharmaceuticals Inc | composto promotor de apoptose, uso e mÉtodo de produÇço do mesmo e composiÇço farmacÊutica |
| AU2007250443B2 (en) | 2006-05-16 | 2013-06-13 | Pharmascience Inc. | IAP BIR domain binding compounds |
| WO2008014229A2 (en) * | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| KR20090041391A (ko) * | 2006-07-24 | 2009-04-28 | 테트랄로직 파마슈티칼스 | 이량체성 iap 길항제 |
| CL2007002166A1 (es) * | 2006-07-24 | 2008-01-25 | Tetralogic Pharm Corp | Compuestos derivados de heterociclos de nitrogeno, antagonistas de los inhibidores de las proteinas de la apoptosis; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento del cancer. |
| JP5454943B2 (ja) * | 2007-04-12 | 2014-03-26 | ジョイアント ファーマスーティカルズ、インク. | 抗癌剤として有用なsmac模倣二量体及び三量体 |
| PE20130150A1 (es) * | 2007-04-30 | 2013-02-27 | Genentech Inc | Inhibidores de las iap |
| JP2010528587A (ja) * | 2007-05-07 | 2010-08-26 | テトラロジック ファーマシューティカルズ コーポレーション | アポトーシス阻害タンパク質のアンタゴニストに対する感受性のバイオマーカーとしてTNFα遺伝子の発現を用いる方法 |
| WO2008144925A1 (en) * | 2007-05-30 | 2008-12-04 | Aegera Therapeutics Inc. | Iap bir domain binding compounds |
| MX2010011288A (es) | 2008-04-23 | 2010-11-09 | Rigel Pharmaceuticals Inc | Compuestos de carboxamida para el tratamiento de trastornos metabolicos. |
| WO2009136290A1 (en) * | 2008-05-05 | 2009-11-12 | Aegera Therapeutics, Inc. | Functionalized pyrrolidines and use thereof as iap inhibitors |
| WO2009155709A1 (en) * | 2008-06-27 | 2009-12-30 | Aegera Therapeutics Inc. | Bridged secondary amines and use thereof as iap bir domain binding compounds |
| CN102171209A (zh) * | 2008-08-02 | 2011-08-31 | 健泰科生物技术公司 | Iap抑制剂 |
| WO2010015090A1 (en) * | 2008-08-07 | 2010-02-11 | Aegera Therapeutics Inc. | Functionalized pyrrolidines and use thereof as iap inhibitors |
| US20110177060A1 (en) * | 2008-09-19 | 2011-07-21 | Aegera Therapeutics, Inc. | Iap bir domain binding compounds |
| US20100317593A1 (en) * | 2009-06-12 | 2010-12-16 | Astrazeneca Ab | 2,3-dihydro-1h-indene compounds |
| US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
| EP2784076A1 (en) * | 2009-10-28 | 2014-10-01 | Joyant Pharmaceuticals, Inc. | Dimeric SMAC mimetics |
| WO2011098904A1 (en) | 2010-02-12 | 2011-08-18 | Aegera Therapeutics, Inc. | Iap bir domain binding compounds |
| UY33236A (es) | 2010-02-25 | 2011-09-30 | Novartis Ag | Inhibidores dimericos de las iap |
| WO2012052758A1 (en) * | 2010-10-22 | 2012-04-26 | Astrazeneca Ab | Response biomarkers for iap antagonists in human cancers |
| UY33794A (es) | 2010-12-13 | 2012-07-31 | Novartis Ag | Inhibidores diméricos de las iap |
| WO2015196091A1 (en) | 2014-06-20 | 2015-12-23 | Reform Biologics, Llc | Viscosity-reducing excipient compounds for protein formulations |
| WO2020112855A1 (en) * | 2018-11-29 | 2020-06-04 | Reform Biologics, Llc | Excipient compounds for protein processing |
| US10478498B2 (en) | 2014-06-20 | 2019-11-19 | Reform Biologics, Llc | Excipient compounds for biopolymer formulations |
| US11357857B2 (en) | 2014-06-20 | 2022-06-14 | Comera Life Sciences, Inc. | Excipient compounds for protein processing |
| CA2916970A1 (en) * | 2016-01-08 | 2017-07-08 | Pharmascience Inc. | A smac mimetic compound for use in the treatment of proliferative diseases |
| AU2018308116A1 (en) * | 2017-07-25 | 2020-02-13 | Hepagene Therapeutics (HK) Limited | Dimeric peptide inhibitors of apoptosis proteins |
| CN109407133B (zh) * | 2017-08-18 | 2023-09-22 | 南京中硼联康医疗科技有限公司 | 生物剂量计及具有其的中子捕获治疗系统 |
| JP2021523092A (ja) * | 2018-03-21 | 2021-09-02 | ピラマル・ファーマ・リミテッドPiramal Pharma Limited | アルファ−(ジアリールメチル)アルキルアミンの改良された不斉合成 |
| WO2020027225A1 (ja) | 2018-07-31 | 2020-02-06 | ファイメクス株式会社 | 複素環化合物 |
| CN113677399B (zh) * | 2019-04-05 | 2024-10-11 | 和博医药有限公司 | 凋亡蛋白抑制剂的二价拮抗剂 |
| WO2020223403A1 (en) * | 2019-04-29 | 2020-11-05 | The Regents Of The University Of California | Anticancer smac derivatives |
| WO2021020585A1 (ja) | 2019-07-31 | 2021-02-04 | ファイメクス株式会社 | 複素環化合物 |
| JP2023510426A (ja) | 2020-01-20 | 2023-03-13 | アストラゼネカ・アクチエボラーグ | 癌を治療するための上皮細胞増殖因子受容体チロシンキナーゼ阻害剤 |
| US11814367B2 (en) | 2021-03-15 | 2023-11-14 | Maze Therapeutics, Inc. | Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof |
| JP7260725B1 (ja) * | 2021-12-27 | 2023-04-18 | 株式会社トクヤマ | ペプチド製造方法、保護基の除去方法、及び除去剤 |
| WO2023127331A1 (ja) * | 2021-12-27 | 2023-07-06 | 株式会社トクヤマ | ペプチド製造方法、保護基の除去方法、除去剤、及びベンジル化合物 |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US93428A (en) * | 1869-08-10 | Improvement in spurs for excelsior-machines | ||
| US180828A (en) * | 1876-08-08 | Improvement in horse-powers | ||
| US207525A (en) * | 1878-08-27 | Improvement in car-coupling draw-bars | ||
| US89896A (en) * | 1869-05-11 | Improvement in bee-hive | ||
| US194741A (en) * | 1877-08-28 | Improvement in circular looms | ||
| US219140A (en) * | 1879-09-02 | Improvement in the art of ornamenting metallic foils | ||
| US69812A (en) * | 1867-10-15 | Improved refrigerator | ||
| US93429A (en) * | 1869-08-10 | Improvement in flasks for vulcanizing rubber plates for setting teeth | ||
| US25347A (en) * | 1859-09-06 | Improvement | ||
| US258581A (en) * | 1882-05-30 | husset | ||
| US211627A (en) * | 1879-01-28 | Improvement in perforating-stamps | ||
| US32437A (en) * | 1861-05-28 | Improvement in steam-plows | ||
| JPH0680077B2 (ja) | 1985-02-08 | 1994-10-12 | サントリー株式会社 | プロリンエンドペプチダ−ゼインヒビタ−活性を有する新規ペプチド化合物 |
| JPH04208299A (ja) | 1990-11-30 | 1992-07-29 | Ajinomoto Co Inc | プロリルエンドペプチターゼ阻害ペプチド |
| US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| AUPN727595A0 (en) * | 1995-12-22 | 1996-01-18 | Walter And Eliza Hall Institute Of Medical Research, The | Therapeutic compositions |
| JP4208299B2 (ja) | 1998-08-19 | 2009-01-14 | 東レ株式会社 | 金属板貼合わせ成形加工用ポリエステルフィルム |
| US6110691A (en) | 2000-01-06 | 2000-08-29 | Board Of Regents, The University Of Texas System | Activators of caspases |
| US6608026B1 (en) | 2000-08-23 | 2003-08-19 | Board Of Regents, The University Of Texas System | Apoptotic compounds |
| US6992063B2 (en) | 2000-09-29 | 2006-01-31 | The Trustees Of Princeton University | Compositions and method for regulating apoptosis |
| AU2001293189A1 (en) | 2000-09-29 | 2002-04-08 | Trustees Of Princeton University | Compositions and methods for regulating apoptosis |
| WO2002030959A2 (en) | 2000-10-13 | 2002-04-18 | Abbott Laboratories | Peptides derived from smac (diablo) and methods of use therefor |
| EP1392317A4 (en) * | 2001-05-16 | 2005-10-19 | Antexpharma Inc | SUBSTITUTED 1-BENZAZEPINE AND DERIVATIVES THEREOF |
| CA2449168A1 (en) | 2001-05-31 | 2002-12-05 | The Trustees Of Princeton University | Iap binding peptides and assays for identifying compounds that bind iap |
| ES2278928T3 (es) * | 2001-06-19 | 2007-08-16 | Altana Pharma Ag | Inhibidores de triptasa. |
| US20060258581A1 (en) | 2001-11-21 | 2006-11-16 | Reed John C | Methods and composition for derepressions of IAP-inhibited caspase |
| EP1495124A2 (en) | 2002-04-17 | 2005-01-12 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Smac-peptides as therapeutics against cancer and autoimmune diseases |
| WO2004005248A1 (en) * | 2002-07-02 | 2004-01-15 | Novartis Ag | Peptide inhibitors of smac protein binding to inhibitor of apoptosis proteins (iap) |
| ATE415413T1 (de) | 2002-07-15 | 2008-12-15 | Univ Princeton | Iap-bindende verbindungen |
| FR2844271A1 (fr) * | 2002-09-09 | 2004-03-12 | Oreal | Derives bis-paraphenylenediamine a groupement pyrrolidinyle et utilisation de ces derives pour la coloration de fibres keratiniques |
| US7229617B2 (en) | 2002-11-27 | 2007-06-12 | Irm Llc | Methods and compositions for inducing apoptosis in cancer cells |
| WO2004066958A2 (en) | 2003-01-30 | 2004-08-12 | The Trustees Of Princeton University | Caspase-9:bir3 domain of xiap complexes and methods of use |
| WO2005049853A2 (en) * | 2003-11-13 | 2005-06-02 | Genentech, Inc. | Compositions and methods for screening pro-apoptotic compounds |
| CA2553871A1 (en) | 2004-01-16 | 2005-08-04 | The Regents Of The University Of Michigan | Smac peptidomimetics and the uses thereof |
| KR20060126548A (ko) | 2004-02-05 | 2006-12-07 | 노파르티스 아게 | (a) DNA 토포이소머라제 억제제 및 (b) IAP 억제제조합물 |
| CN1926118A (zh) * | 2004-03-01 | 2007-03-07 | 德克萨斯大学董事会 | 二聚的小分子细胞凋亡增强剂 |
| WO2005094818A1 (en) | 2004-03-23 | 2005-10-13 | Genentech, Inc. | Azabicyclo-octane inhibitors of iap |
| RS52545B (sr) | 2004-04-07 | 2013-04-30 | Novartis Ag | Inhibitori protein apoptoze (iap) |
| BRPI0511350A (pt) | 2004-07-02 | 2007-12-04 | Genentech Inc | composto, métodos de indução da apoptose em uma célula, de sensibilização de uma célula à um sinal apoptótico, de inibição da ligação de uma proteìna iap e de tratamento de uma doença e cáncer e usos de um composto |
| US7674787B2 (en) | 2004-07-09 | 2010-03-09 | The Regents Of The University Of Michigan | Conformationally constrained Smac mimetics and the uses thereof |
| EP1773348A4 (en) | 2004-07-12 | 2009-05-20 | Idun Pharmaceuticals Inc | TETRA PEPTIDE ANALOGS |
| AU2005274937B2 (en) | 2004-07-15 | 2011-08-18 | Medivir Ab | IAP binding compounds |
| MX2007007195A (es) | 2004-12-20 | 2007-10-08 | Genentech Inc | Inhibidores de pirrolidina de iap. |
| ES2456671T3 (es) | 2005-02-25 | 2014-04-23 | Tetralogic Pharmaceuticals Corporation | Inhibidores diméricos de IAP |
| US20070003535A1 (en) | 2005-03-17 | 2007-01-04 | Reed John C | Methods and compositions for derepression of IAP-inhibited caspase |
| DE102005017116A1 (de) | 2005-04-13 | 2006-10-26 | Novartis Ag | Hemmstoffe für Inhibitoren von Apoptose Proteinen (IAP) |
| US7772177B2 (en) | 2005-05-18 | 2010-08-10 | Aegera Therapeutics, Inc. | BIR domain binding compounds |
| EP1888619B1 (en) | 2005-05-25 | 2013-04-17 | 2cureX ApS | Compounds modifying apoptosis |
| JP2008545780A (ja) | 2005-06-08 | 2008-12-18 | ノバルティス アクチエンゲゼルシャフト | 有機化合物 |
| WO2007021825A2 (en) * | 2005-08-09 | 2007-02-22 | Tetralogic Pharmaceuticals Corporation | Treatment of proliferative disorders |
| WO2007048224A1 (en) | 2005-10-25 | 2007-05-03 | Aegera Therapeutics Inc. | Iap bir domain binding compounds |
| WO2007106192A2 (en) | 2005-12-19 | 2007-09-20 | Genentech, Inc. | Inhibitors of iap |
| WO2007075525A2 (en) | 2005-12-20 | 2007-07-05 | Novartis Ag | Combination of an iap-inhibitor and a taxane7 |
| WO2007101347A1 (en) | 2006-03-07 | 2007-09-13 | Aegera Therapeutics Inc. | Bir domain binding compounds |
| TWI504597B (zh) | 2006-03-16 | 2015-10-21 | Pharmascience Inc | 結合於細胞凋亡抑制蛋白(iap)之桿狀病毒iap重複序列(bir)區域之化合物 |
| BRPI0708942A2 (pt) | 2006-03-21 | 2011-06-14 | Joyant Pharmaceuticals Inc | composto promotor de apoptose, uso e mÉtodo de produÇço do mesmo e composiÇço farmacÊutica |
| JP5230610B2 (ja) | 2006-05-05 | 2013-07-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 二価smac模倣物およびその使用 |
| AU2007250443B2 (en) | 2006-05-16 | 2013-06-13 | Pharmascience Inc. | IAP BIR domain binding compounds |
| KR20090041391A (ko) | 2006-07-24 | 2009-04-28 | 테트랄로직 파마슈티칼스 | 이량체성 iap 길항제 |
| WO2008014229A2 (en) | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| US20100056495A1 (en) | 2006-07-24 | 2010-03-04 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| WO2008014238A2 (en) | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| CL2007002166A1 (es) | 2006-07-24 | 2008-01-25 | Tetralogic Pharm Corp | Compuestos derivados de heterociclos de nitrogeno, antagonistas de los inhibidores de las proteinas de la apoptosis; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento del cancer. |
| WO2008014240A2 (en) | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| PE20110220A1 (es) | 2006-08-02 | 2011-04-11 | Novartis Ag | DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS |
| US8044209B2 (en) | 2006-10-12 | 2011-10-25 | Novartis Ag | Pyrrolydine derivatives as IAP inhibitors |
| KR20090082221A (ko) | 2006-10-19 | 2009-07-29 | 노파르티스 아게 | 유기 화합물 |
| CN101541325A (zh) | 2006-11-28 | 2009-09-23 | 诺瓦提斯公司 | Iap抑制剂用于治疗急性髓性白血病的用途 |
| KR20090087094A (ko) | 2006-11-28 | 2009-08-14 | 노파르티스 아게 | Iap 억제제 및 flt3 억제제의 조합물 |
| ATE542798T1 (de) | 2006-12-07 | 2012-02-15 | Novartis Ag | Organische verbindungen |
| US8063218B2 (en) | 2006-12-19 | 2011-11-22 | Genentech, Inc. | Imidazopyridine inhibitors of IAP |
| JP5454943B2 (ja) | 2007-04-12 | 2014-03-26 | ジョイアント ファーマスーティカルズ、インク. | 抗癌剤として有用なsmac模倣二量体及び三量体 |
| WO2008128171A2 (en) | 2007-04-13 | 2008-10-23 | The Regents Of The University Of Michigan | Diazo bicyclic smac mimetics and the uses thereof |
| PE20130150A1 (es) | 2007-04-30 | 2013-02-27 | Genentech Inc | Inhibidores de las iap |
| WO2008144925A1 (en) | 2007-05-30 | 2008-12-04 | Aegera Therapeutics Inc. | Iap bir domain binding compounds |
| EP2058312A1 (en) | 2007-11-09 | 2009-05-13 | Universita' degli Studi di Milano | SMAC mimetic compounds as apoptosis inducers |
-
2007
- 2007-03-15 TW TW096108935A patent/TWI504597B/zh not_active IP Right Cessation
- 2007-03-15 TW TW103145747A patent/TWI543988B/zh not_active IP Right Cessation
- 2007-03-16 MX MX2008011837A patent/MX2008011837A/es active IP Right Grant
- 2007-03-16 NZ NZ571577A patent/NZ571577A/en not_active IP Right Cessation
- 2007-03-16 CA CA2581960A patent/CA2581960C/en not_active Expired - Fee Related
- 2007-03-16 AU AU2007224932A patent/AU2007224932B2/en not_active Ceased
- 2007-03-16 US US11/723,044 patent/US7579320B2/en not_active Expired - Fee Related
- 2007-03-16 EP EP07710756A patent/EP2004600A4/en not_active Withdrawn
- 2007-03-16 BR BRPI0709610-0A patent/BRPI0709610A2/pt not_active IP Right Cessation
- 2007-03-16 SG SG201101952-8A patent/SG170739A1/en unknown
- 2007-03-16 JP JP2008558611A patent/JP5419468B2/ja not_active Expired - Fee Related
- 2007-03-16 WO PCT/CA2007/000428 patent/WO2007104162A1/en not_active Ceased
- 2007-03-16 KR KR1020087025218A patent/KR101446907B1/ko not_active Expired - Fee Related
- 2007-11-01 US US11/979,280 patent/US7645741B2/en not_active Expired - Fee Related
-
2008
- 2008-09-07 IL IL193951A patent/IL193951A/en not_active IP Right Cessation
- 2008-09-09 NO NO20083868A patent/NO20083868L/no not_active Application Discontinuation
-
2009
- 2009-11-17 US US12/619,979 patent/US20100221261A1/en not_active Abandoned
-
2012
- 2012-11-08 US US13/672,637 patent/US8765681B2/en not_active Expired - Fee Related
-
2014
- 2014-05-23 US US14/285,841 patent/US9365614B2/en not_active Expired - Fee Related
- 2014-10-28 PH PH12014502420A patent/PH12014502420B1/en unknown
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