JP2009526756A5 - - Google Patents
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- JP2009526756A5 JP2009526756A5 JP2008550490A JP2008550490A JP2009526756A5 JP 2009526756 A5 JP2009526756 A5 JP 2009526756A5 JP 2008550490 A JP2008550490 A JP 2008550490A JP 2008550490 A JP2008550490 A JP 2008550490A JP 2009526756 A5 JP2009526756 A5 JP 2009526756A5
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- JP
- Japan
- Prior art keywords
- antagonist
- osmrb
- composition
- treating
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000003042 antagnostic Effects 0.000 claims 17
- 239000005557 antagonist Substances 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 11
- 101700032890 OSMR Proteins 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 3
- 210000003594 Ganglia, Spinal Anatomy 0.000 claims 2
- 210000001519 tissues Anatomy 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims 1
- 210000000944 Nerve Tissue Anatomy 0.000 claims 1
- 102100019816 OSMR Human genes 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 210000000278 Spinal Cord Anatomy 0.000 claims 1
- 206010047461 Viral infection Diseases 0.000 claims 1
- 208000001756 Virus Disease Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 102000004965 antibodies Human genes 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 230000017613 viral reproduction Effects 0.000 claims 1
Claims (11)
- ＩＬ−３１ＲＡアンタゴニストまたはＯＳＭＲｂアンタゴニストを含んでなる、哺乳動物の神経組織の炎症を治療するための組成物。
- ＩＬ−３１ＲａアンタゴニストまたはＯＳＭＲｂアンタゴニストを含んでなる、哺乳動物の疼痛を治療するための組成物。
- ＩＬ−３１ＲａアンタゴニストまたはＯＳＭＲｂアンタゴニストを含んでなる、後根神経節細胞におけるＩＬ−３１によって誘導されるシグナル伝達に拮抗するための組成物。
- ＩＬ−３１ＲａアンタゴニストまたはＯＳＭＲｂアンタゴニストを含んでなる、熱傷に関連した症状を治療するための組成物。
- ＩＬ−３１ＲａアンタゴニストまたはＯＳＭＲｂアンタゴニストを含んでなる、哺乳動物におけるウイルス感染症に関連した症状を治療するための組成物。
- ＩＬ−３１ＲＡアンタゴニストまたはＯＳＭＲｂアンタゴニストを含んでなる、炎症性腸疾患に関連した疼痛を治療するための組成物。
- ＩＬ−３１ＲａアンタゴニストまたはＯＳＭＲＢアンタゴニストが、配列番号２に示すアミノ酸配列の残基２７〜残基１６４を含むポリペプチドに結合する、請求項１〜６のいずれか一項記載の組成物。
- アンタゴニストが、１つまたは複数の可溶性ＩＬ−３１Ｒａサブユニットを含む可溶性受容体である、請求項７記載の組成物。
- アンタゴニストが抗体である、請求項１〜６のいずれか一項記載の組成物。
- 神経組織が、後根神経節または脊髄組織を含む、請求項１〜６のいずれか一項記載の組成物。
- 症状が疼痛またはそう痒である、請求項４又は５記載の組成物。
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75797906P | 2006-01-10 | 2006-01-10 | |
| US75806606P | 2006-01-10 | 2006-01-10 | |
| US77303106P | 2006-02-14 | 2006-02-14 | |
| US80555006P | 2006-06-22 | 2006-06-22 | |
| US80555406P | 2006-06-22 | 2006-06-22 | |
| US80555206P | 2006-06-22 | 2006-06-22 | |
| US82398206P | 2006-08-30 | 2006-08-30 | |
| US82398706P | 2006-08-30 | 2006-08-30 | |
| PCT/US2007/060337 WO2007133816A2 (en) | 2006-01-10 | 2007-01-10 | Methods of treating pain and inflammation in neuronal tissue using il-31ra and osmrb antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009526756A JP2009526756A (ja) | 2009-07-23 |
| JP2009526756A5 true JP2009526756A5 (ja) | 2010-02-25 |
Family
ID=38694567
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008550488A Pending JP2009528264A (ja) | 2006-01-10 | 2007-01-10 | Ｉｌ−３１アンタゴニストを用いて神経組織における疼痛及び炎症を治療する方法 |
| JP2008550490A Pending JP2009526756A (ja) | 2006-01-10 | 2007-01-10 | Ｉｌ−３１ｒａアンタゴニストおよびｏｓｍｒｂアンタゴニストを用いて神経組織における疼痛および炎症を治療する方法 |
| JP2012240592A Pending JP2013047259A (ja) | 2006-01-10 | 2012-10-31 | Ｉｌ−３１アンタゴニストを用いて神経組織における疼痛及び炎症を治療する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008550488A Pending JP2009528264A (ja) | 2006-01-10 | 2007-01-10 | Ｉｌ−３１アンタゴニストを用いて神経組織における疼痛及び炎症を治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012240592A Pending JP2013047259A (ja) | 2006-01-10 | 2012-10-31 | Ｉｌ−３１アンタゴニストを用いて神経組織における疼痛及び炎症を治療する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (22) | US7514077B2 (ja) |
| EP (4) | EP1991581A2 (ja) |
| JP (3) | JP2009528264A (ja) |
| KR (1) | KR101345586B1 (ja) |
| AU (2) | AU2007254715B2 (ja) |
| BR (1) | BRPI0706487A2 (ja) |
| CA (2) | CA2633439A1 (ja) |
| IL (4) | IL192130A0 (ja) |
| MX (1) | MX2008008831A (ja) |
| RU (1) | RU2565391C2 (ja) |
| WO (2) | WO2007143231A2 (ja) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60043728D1 (de) | 1999-06-02 | 2010-03-11 | Chugai Pharmaceutical Co Ltd | Neues hämopoietin rezeptorprotein nr10 |
| AU7445900A (en) | 1999-09-27 | 2001-04-30 | Chugai Seiyaku Kabushiki Kaisha | Novel hemopoietin receptor protein, nr12 |
| EP1961811B1 (en) * | 2002-01-18 | 2010-08-25 | ZymoGenetics, Inc. | Cytokine ligand for the treatment of asthma and airway hyper-responsiveness |
| MX2007009577A (es) | 2005-02-14 | 2008-01-30 | Zymogenetics Inc | Metodos para predecir respuesta terapeutica en dermatitis atopica a antagonistas del il-31. |
| EP1858924A1 (en) | 2005-02-14 | 2007-11-28 | ZymoGenetics, Inc. | Methods of treating skin disorders using an il-31ra antagonist |
| WO2007143231A2 (en) | 2006-01-10 | 2007-12-13 | Zymogenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using il-31 antagonists |
| US20130216542A1 (en) | 2005-05-06 | 2013-08-22 | Zymogenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
| KR101446989B1 (ko) | 2005-05-06 | 2014-10-15 | 지모제넥틱스, 인코포레이티드 | Ｉｌ-31 단클론성 항체 및 사용법 |
| US8101183B2 (en) | 2005-05-06 | 2012-01-24 | Zymogentics, Inc. | Variable region sequences of IL-31 monoclonal antibodies |
| CN101479381B (zh) | 2006-03-31 | 2015-04-29 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| CN101500608A (zh) * | 2006-06-08 | 2009-08-05 | 中外制药株式会社 | 炎性疾病的预防或治疗药 |
| EP2061811A2 (en) | 2006-09-01 | 2009-05-27 | ZymoGenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
| US7799323B2 (en) | 2007-01-10 | 2010-09-21 | Zymogenetics, Inc. | Methods of using IL-31 to treat airway hyper-responsiveness and asthma |
| TWI563002B (en) | 2007-09-26 | 2016-12-21 | Chugai Pharmaceutical Co Ltd | Antibody constant region mutant |
| US9096651B2 (en) | 2007-09-26 | 2015-08-04 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in CDR |
| MY185647A (en) * | 2007-12-05 | 2021-05-27 | Chugai Pharmaceutical Co Ltd | Therapeutic agent for pruritus |
| ES2834741T3 (es) | 2007-12-05 | 2021-06-18 | Chugai Pharmaceutical Co Ltd | Anticuerpo anti-NR10 y uso del mismo |
| RS56930B1 (sr) | 2007-12-07 | 2018-05-31 | Zymogenetics Inc | Molekuli humanizovanih antitela specifični za il-31 |
| CN103251948A (zh) | 2008-04-11 | 2013-08-21 | 中外制药株式会社 | 与多个分子的抗原反复结合的抗原结合分子 |
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| EP3674317A1 (en) | 2009-03-19 | 2020-07-01 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| WO2010107110A1 (ja) | 2009-03-19 | 2010-09-23 | 中外製薬株式会社 | 抗体定常領域改変体 |
| EP2348128A1 (en) * | 2010-01-21 | 2011-07-27 | Sanofi | Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia |
| CN107973851A (zh) | 2010-11-30 | 2018-05-01 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| US8987289B2 (en) * | 2012-12-14 | 2015-03-24 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
| US20140179727A1 (en) | 2012-12-14 | 2014-06-26 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
| US10039792B1 (en) | 2013-03-16 | 2018-08-07 | Brahm Holdings, Llc | Methods for the treatment of inflammation and pain using human birth tissue material composition |
| WO2014160883A1 (en) | 2013-03-27 | 2014-10-02 | Cedars-Sinai Medical Center | Treating fibrosis and inflammation by inhibiting tl1a |
| DK3004167T3 (en) * | 2013-05-30 | 2018-11-12 | Kiniksa Pharmaceuticals Ltd | ONCOSTATIN M-RECEPTOR ANTIGIN BINDING PROTEINS |
| WO2015010108A1 (en) | 2013-07-19 | 2015-01-22 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
| KR20170132143A (ko) * | 2015-01-29 | 2017-12-01 | 옥스포드 유니버시티 이노베이션 리미티드 | 바이오마커 |
| US10544227B2 (en) | 2015-04-14 | 2020-01-28 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for prevention and/or treatment of atopic dermatitis comprising IL-31 antagonist as active ingredient |
| KR20240033097A (ko) | 2015-04-14 | 2024-03-12 | 추가이 세이야쿠 가부시키가이샤 | Il-31 안타고니스트를 유효 성분으로서 함유하는 아토피성 피부염의 예방용 및/또는 치료용 의약 조성물 |
| WO2017033951A1 (ja) * | 2015-08-24 | 2017-03-02 | 学校法人国際医療福祉大学 | 新規鎮痛剤 |
| AU2016353988B2 (en) * | 2015-11-09 | 2019-09-26 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders |
| JP7082945B2 (ja) | 2016-03-17 | 2022-06-09 | シーダーズ―シナイ メディカル センター | Ｒｎａｓｅｔ２により炎症性腸疾患を診断する方法 |
| CN110545844A (zh) | 2017-02-21 | 2019-12-06 | 瑞美德生物医药科技有限公司 | 使用结合细胞毒性t淋巴细胞抗原-4(ctla-4)的抗体的癌症治疗 |
| KR20230157533A (ko) | 2017-02-23 | 2023-11-16 | 매직 립, 인코포레이티드 | 가변 파워 반사기를 갖는 디스플레이 시스템 |
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| AU2019234220A1 (en) | 2018-03-16 | 2020-09-10 | Zoetis Services Llc | Interleukin-31 monoclonal antibodies for veterinary use |
| MX2021000908A (es) | 2018-07-23 | 2021-06-08 | Trevi Therapeutics Inc | Tratamiento de la tos cronica, la dificultad respiratoria y la disnea. |
| RU2707954C1 (ru) * | 2019-01-24 | 2019-12-02 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ лечения онкологической боли |
| EP4062933A4 (en) | 2019-11-20 | 2023-12-13 | Chugai Seiyaku Kabushiki Kaisha | PHARMACEUTICAL PREPARATION COMPRISING AN ANTIBODY |
| CN116096411A (zh) * | 2020-09-01 | 2023-05-09 | 中外制药株式会社 | 含有作为活性成分的il-31拮抗剂的用于预防和/或治疗透析瘙痒的药物组合物 |
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| US8101183B2 (en) * | 2005-05-06 | 2012-01-24 | Zymogentics, Inc. | Variable region sequences of IL-31 monoclonal antibodies |
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2007
- 2007-01-10 WO PCT/US2007/060330 patent/WO2007143231A2/en active Application Filing
- 2007-01-10 EP EP07811781A patent/EP1991581A2/en not_active Withdrawn
- 2007-01-10 WO PCT/US2007/060337 patent/WO2007133816A2/en active Application Filing
- 2007-01-10 EP EP13154292.0A patent/EP2594585A1/en not_active Withdrawn
- 2007-01-10 JP JP2008550488A patent/JP2009528264A/ja active Pending
- 2007-01-10 CA CA002633439A patent/CA2633439A1/en not_active Withdrawn
- 2007-01-10 US US11/621,829 patent/US7514077B2/en active Active
- 2007-01-10 AU AU2007254715A patent/AU2007254715B2/en active Active
- 2007-01-10 CA CA2636288A patent/CA2636288C/en active Active
- 2007-01-10 EP EP14161547.6A patent/EP2749571A3/en not_active Withdrawn
- 2007-01-10 AU AU2007249713A patent/AU2007249713A1/en not_active Abandoned
- 2007-01-10 US US11/621,840 patent/US7638126B2/en active Active
- 2007-01-10 MX MX2008008831A patent/MX2008008831A/es active IP Right Grant
- 2007-01-10 BR BRPI0706487-0A patent/BRPI0706487A2/pt not_active Application Discontinuation
- 2007-01-10 JP JP2008550490A patent/JP2009526756A/ja active Pending
- 2007-01-10 EP EP07777559A patent/EP2001906A2/en not_active Withdrawn
- 2007-01-10 KR KR1020087019496A patent/KR101345586B1/ko active IP Right Grant
- 2007-01-10 RU RU2011137369/15A patent/RU2565391C2/ru active
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2008
- 2008-06-12 IL IL192130A patent/IL192130A0/en unknown
- 2008-06-19 IL IL192296A patent/IL192296A0/en unknown
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2009
- 2009-02-27 US US12/395,095 patent/US7939068B2/en active Active
- 2009-10-28 US US12/607,831 patent/US7943132B2/en active Active
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2011
- 2011-03-30 US US13/075,412 patent/US8105590B2/en active Active
- 2011-03-30 US US13/075,845 patent/US8105591B2/en active Active
- 2011-12-20 US US13/331,145 patent/US8377438B2/en active Active
- 2011-12-21 US US13/332,758 patent/US8409571B2/en active Active
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2012
- 2012-05-09 IL IL219678A patent/IL219678A0/en unknown
- 2012-05-09 IL IL219677A patent/IL219677A0/en unknown
- 2012-10-31 JP JP2012240592A patent/JP2013047259A/ja active Pending
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2013
- 2013-01-23 US US13/747,899 patent/US8637015B2/en active Active
- 2013-03-07 US US13/788,454 patent/US8685395B2/en active Active
- 2013-12-19 US US14/134,278 patent/US8968732B2/en active Active
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2014
- 2014-02-07 US US14/175,117 patent/US8974783B2/en active Active
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2015
- 2015-01-23 US US14/603,406 patent/US9334321B2/en active Active
- 2015-01-27 US US14/606,063 patent/US9334322B2/en active Active
-
2016
- 2016-04-15 US US15/099,639 patent/US9631021B2/en active Active
- 2016-04-15 US US15/099,647 patent/US9631022B2/en active Active
-
2017
- 2017-03-15 US US15/459,901 patent/US9834602B2/en active Active
- 2017-03-16 US US15/461,090 patent/US9828431B2/en active Active
- 2017-10-31 US US15/799,445 patent/US20180044426A1/en not_active Abandoned
- 2017-11-01 US US15/800,980 patent/US20180066050A1/en not_active Abandoned
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2018
- 2018-12-20 US US16/227,307 patent/US20190112369A1/en not_active Abandoned
- 2018-12-20 US US16/227,266 patent/US20190119372A1/en not_active Abandoned
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