JP2010513327A5 - - Google Patents
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- JP2010513327A5 JP2010513327A5 JP2009541705A JP2009541705A JP2010513327A5 JP 2010513327 A5 JP2010513327 A5 JP 2010513327A5 JP 2009541705 A JP2009541705 A JP 2009541705A JP 2009541705 A JP2009541705 A JP 2009541705A JP 2010513327 A5 JP2010513327 A5 JP 2010513327A5
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- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- pharmaceutical composition
- subject
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 229920001184 polypeptide Polymers 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 206010008118 Cerebral infarction Diseases 0.000 claims 1
- 206010053487 Exposure to toxic agent Diseases 0.000 claims 1
- 206010061216 Infarction Diseases 0.000 claims 1
- 206010022114 Injury Diseases 0.000 claims 1
- 206010067229 Paraneoplastic syndrome Diseases 0.000 claims 1
- 208000008513 Spinal Cord Injury Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000036210 malignancy Effects 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 239000003106 tissue adhesive Substances 0.000 claims 1
Claims (7)
- 配列番号４、配列番号６、配列番号１４、配列番号１８、配列番号２０、配列番号２５、配列番号３０、配列番号３５、配列番号３７、及び配列番号１０、並びにこれらのアナログからなる群から選択されるポリペプチド。
- 前記配列番号４、配列番号６、配列番号１４、配列番号１８、配列番号２０、配列番号２５、配列番号３０、配列番号３５、配列番号３７、および配列番号１０からなる群から選択されるポリペプチドが、Ｎ末端で２０アミノ酸トランケートされた、請求項１に記載のポリペプチド。
- 前記ポリペプチドがＰＥＧ化された請求項１または２に記載のポリペプチド。
- ａ）請求項１〜３のいずれか１項に記載のポリペプチドおよびｂ）薬学的に許容されるキャリアを含む医薬組成物。
- 前記キャリアが組織接着剤を含む、請求項４に記載の医薬組成物。
- 被療者における脊髄損傷を治療するための、請求項４または５に記載の医薬組成物。
- 前記被療者が、脳梗塞、手術、梗塞症、感染症、毒性薬剤への暴露、悪性腫瘍または腫瘍随伴症候群、外傷または事故による損傷を原因とする神経系損傷を有する、請求項６に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/643,940 US20070270340A1 (en) | 2001-04-12 | 2006-12-22 | ADP-ribosyl transferase fusion variant proteins |
| US11/808,773 US7795218B2 (en) | 2001-04-12 | 2007-06-12 | ADP-ribosyl transferase fusion variant proteins |
| PCT/CA2007/002265 WO2008077236A1 (en) | 2006-12-22 | 2007-12-12 | Adp-ribosyl transferase fusion variant proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013097396A Division JP5917437B2 (ja) | 2006-12-22 | 2013-05-07 | Ａｄｐリボシルトランスフェラーゼ融合バリアントタンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010513327A JP2010513327A (ja) | 2010-04-30 |
| JP2010513327A5 true JP2010513327A5 (ja) | 2011-02-03 |
Family
ID=39562050
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009541705A Pending JP2010513327A (ja) | 2006-12-22 | 2007-12-12 | Ａｄｐリボシルトランスフェラーゼ融合バリアントタンパク質 |
| JP2013097396A Expired - Fee Related JP5917437B2 (ja) | 2006-12-22 | 2013-05-07 | Ａｄｐリボシルトランスフェラーゼ融合バリアントタンパク質 |
| JP2016076887A Pending JP2016135134A (ja) | 2006-12-22 | 2016-04-06 | Ａｄｐリボシルトランスフェラーゼ融合バリアントタンパク質 |
| JP2017141679A Pending JP2017192397A (ja) | 2006-12-22 | 2017-07-21 | Ａｄｐリボシルトランスフェラーゼ融合バリアントタンパク質 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013097396A Expired - Fee Related JP5917437B2 (ja) | 2006-12-22 | 2013-05-07 | Ａｄｐリボシルトランスフェラーゼ融合バリアントタンパク質 |
| JP2016076887A Pending JP2016135134A (ja) | 2006-12-22 | 2016-04-06 | Ａｄｐリボシルトランスフェラーゼ融合バリアントタンパク質 |
| JP2017141679A Pending JP2017192397A (ja) | 2006-12-22 | 2017-07-21 | Ａｄｐリボシルトランスフェラーゼ融合バリアントタンパク質 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7795218B2 (ja) |
| EP (2) | EP2407536B1 (ja) |
| JP (4) | JP2010513327A (ja) |
| CA (1) | CA2709428C (ja) |
| DK (1) | DK2407536T3 (ja) |
| ES (1) | ES2439772T3 (ja) |
| HK (1) | HK1164936A1 (ja) |
| WO (1) | WO2008077236A1 (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7442686B2 (en) | 2001-04-12 | 2008-10-28 | Bioaxone Therapeutique Inc. | Treatment of macular degeneration with ADP-ribosyl transferase fusion protein therapeutic compositions |
| KR20110115589A (ko) * | 2009-01-24 | 2011-10-21 | 파이토팜 피엘씨 | 신경영양인자가 매개된 장애의 치료 |
| GB0904427D0 (en) * | 2009-03-13 | 2009-04-29 | Lachmann Peter | Treatment of diseases related to hyperactivity of the complement system |
| US20130123647A1 (en) | 2011-05-03 | 2013-05-16 | The Research Foundation Of State University Of New York | Methods Useful in Optimizing the Treatment of Neuropathies and Targeting Tissues with Cosmetic Botulinum Injections |
| US10292584B2 (en) * | 2014-01-29 | 2019-05-21 | Dignity Health | Systems and methods for using eye movements to determine states |
| ES2806505T3 (es) | 2014-03-21 | 2021-02-17 | Univ Pittsburgh Commonwealth Sys Higher Education | Procedimientos de preparación de un hidrogel esterilizado de modo terminal que proviene de matriz extracelular |
| AU2015243261B2 (en) | 2014-04-10 | 2020-06-25 | Lankenau Institute For Medical Research | Methods and compositions for the treatment of ocular diseases and disorders |
| CN108699522B (zh) | 2016-01-13 | 2022-05-27 | 高等教育联邦系统-匹兹堡大学 | 血管细胞外基质水凝胶 |
| WO2018222723A1 (en) * | 2017-05-30 | 2018-12-06 | Vertex Pharmaceuticals Incorporated | C3 fusion protein and methods of making and using thereof |
| CN111518746A (zh) * | 2020-05-18 | 2020-08-11 | 南通大学 | 一种角膜微口袋手术实验中微丸的制备方法及应用 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT359652B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
| US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| ATE13810T1 (de) | 1981-06-25 | 1985-07-15 | Serapharm Gmbh & Co Kg | Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundabdeckung. |
| ATE20824T1 (de) | 1981-06-25 | 1986-08-15 | Serapharm Gmbh & Co Kg | Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung. |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
| AT389815B (de) | 1984-03-09 | 1990-02-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US5290552A (en) | 1988-05-02 | 1994-03-01 | Matrix Pharmaceutical, Inc./Project Hear | Surgical adhesive material |
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5273530A (en) | 1990-11-14 | 1993-12-28 | The University Of Rochester | Intraretinal delivery and withdrawal instruments |
| US6197325B1 (en) | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US6117425A (en) | 1990-11-27 | 2000-09-12 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, method of their production and use |
| US6054122A (en) | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| AT398079B (de) | 1991-11-04 | 1994-09-26 | Immuno Ag | Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung |
| US5767079A (en) | 1992-07-08 | 1998-06-16 | Celtrix Pharmaceuticals, Inc. | Method of treating ophthalmic disorders using TGF -β |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| CN1091315A (zh) | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
| US5707643A (en) | 1993-02-26 | 1998-01-13 | Santen Pharmaceutical Co., Ltd. | Biodegradable scleral plug |
| WO1995003009A1 (en) | 1993-07-22 | 1995-02-02 | Oculex Pharmaceuticals, Inc. | Method of treatment of macular degeneration |
| WO1995003807A1 (en) | 1993-07-27 | 1995-02-09 | The University Of Sydney | Treatment of age-related macular degeneration |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| JP3591837B2 (ja) | 1994-02-17 | 2004-11-24 | ニューヨーク・ブラッド・センター・インコーポレイテッド | フィブリン膠およびリポソームを含有する生物学的生体接着剤組成物、その製造方法および使用 |
| ATE244584T1 (de) | 1995-01-16 | 2003-07-15 | Baxter Int | Selbsttragende flächengebilde aus vernetztem fibrin zur hemmung von postoperativen adhäsionen |
| US6965014B1 (en) | 1996-01-16 | 2005-11-15 | Baxter International Inc. | Fibrin material and method for producing and using the same |
| US5834590A (en) | 1995-02-22 | 1998-11-10 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Ingap protein involved in pancreatic islet neogenesis |
| US6299895B1 (en) | 1997-03-24 | 2001-10-09 | Neurotech S.A. | Device and method for treating ophthalmic diseases |
| DE19617369A1 (de) | 1996-04-30 | 1997-11-06 | Immuno Ag | Lagerstabile Fibrinogen-Präparate |
| ZA987019B (en) | 1997-08-06 | 1999-06-04 | Focal Inc | Hemostatic tissue sealants |
| CA2300878A1 (en) | 1997-08-13 | 1999-02-25 | Yale University | Central nervous system axon regeneration |
| CA2214841A1 (en) | 1997-10-31 | 1999-04-30 | Lisa Mckerracher | Rho antagonists and their use to block inhibition of neurite outgrowth |
| US6780411B2 (en) | 1998-05-01 | 2004-08-24 | Zymogenetics, Inc. | Tissue sealant compositions |
| US6378526B1 (en) | 1998-08-03 | 2002-04-30 | Insite Vision, Incorporated | Methods of ophthalmic administration |
| CA2325842C (en) | 2000-11-02 | 2007-08-07 | Lisa Mckerracher | Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof |
| CA2367636C (en) * | 2001-04-12 | 2010-05-04 | Lisa Mckerracher | Fusion proteins |
| US7442686B2 (en) | 2001-04-12 | 2008-10-28 | Bioaxone Therapeutique Inc. | Treatment of macular degeneration with ADP-ribosyl transferase fusion protein therapeutic compositions |
| US20060134140A1 (en) | 2001-04-12 | 2006-06-22 | Dana Lasko | Compositions and methods for treating tumor spreading |
| GB0216865D0 (en) * | 2002-07-19 | 2002-08-28 | Microbiological Res Authority | Targetted agents for nerve regeneration |
| US7083783B2 (en) * | 2004-02-18 | 2006-08-01 | Wisconsin Alumni Research Foundation | Method for treating glaucoma |
| JP5259392B2 (ja) * | 2005-05-31 | 2013-08-07 | ウォーソー・オーソペディック・インコーポレーテッド | 疼痛を治療するための組成物および方法 |
-
2007
- 2007-06-12 US US11/808,773 patent/US7795218B2/en not_active Expired - Fee Related
- 2007-12-12 EP EP10195185.3A patent/EP2407536B1/en active Active
- 2007-12-12 DK DK10195185.3T patent/DK2407536T3/da active
- 2007-12-12 ES ES10195185.3T patent/ES2439772T3/es active Active
- 2007-12-12 WO PCT/CA2007/002265 patent/WO2008077236A1/en active Application Filing
- 2007-12-12 JP JP2009541705A patent/JP2010513327A/ja active Pending
- 2007-12-12 CA CA2709428A patent/CA2709428C/en not_active Expired - Fee Related
- 2007-12-12 EP EP07855547A patent/EP2118275A4/en not_active Withdrawn
-
2012
- 2012-06-13 HK HK12105767.6A patent/HK1164936A1/xx not_active IP Right Cessation
-
2013
- 2013-05-07 JP JP2013097396A patent/JP5917437B2/ja not_active Expired - Fee Related
-
2016
- 2016-04-06 JP JP2016076887A patent/JP2016135134A/ja active Pending
-
2017
- 2017-07-21 JP JP2017141679A patent/JP2017192397A/ja active Pending
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