JP2009520765A5 - - Google Patents

Download PDF

Info

Publication number
JP2009520765A5
JP2009520765A5 JP2008546455A JP2008546455A JP2009520765A5 JP 2009520765 A5 JP2009520765 A5 JP 2009520765A5 JP 2008546455 A JP2008546455 A JP 2008546455A JP 2008546455 A JP2008546455 A JP 2008546455A JP 2009520765 A5 JP2009520765 A5 JP 2009520765A5
Authority
JP
Japan
Prior art keywords
group
formula
alkyl
optionally substituted
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008546455A
Other languages
English (en)
Japanese (ja)
Other versions
JP5317701B2 (ja
JP2009520765A (ja
Filing date
Publication date
Priority claimed from DE102005061623A external-priority patent/DE102005061623A1/de
Application filed filed Critical
Publication of JP2009520765A publication Critical patent/JP2009520765A/ja
Publication of JP2009520765A5 publication Critical patent/JP2009520765A5/ja
Application granted granted Critical
Publication of JP5317701B2 publication Critical patent/JP5317701B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2008546455A 2005-12-21 2006-12-20 ４−（ベンゾイミダゾリルメチルアミノ）−ベンゾアミド及びその塩の改良された製造方法 Expired - Fee Related JP5317701B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005061623A DE102005061623A1 (de) 2005-12-21 2005-12-21 Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen
DE102005061623.2 2005-12-21
PCT/EP2006/070033 WO2007071742A1 (en) 2005-12-21 2006-12-20 Improved process for the preparation of 4-(benzimidazolylmethylamino)-benzamides and the salts thereof

Publications (3)

Publication Number Publication Date
JP2009520765A JP2009520765A (ja) 2009-05-28
JP2009520765A5 true JP2009520765A5 (enExample) 2010-02-18
JP5317701B2 JP5317701B2 (ja) 2013-10-16

Family

ID=37945425

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008546455A Expired - Fee Related JP5317701B2 (ja) 2005-12-21 2006-12-20 ４−（ベンゾイミダゾリルメチルアミノ）−ベンゾアミド及びその塩の改良された製造方法

Country Status (16)

Country Link
US (2) US20070185333A1 (enExample)
EP (1) EP1966171A1 (enExample)
JP (1) JP5317701B2 (enExample)
KR (1) KR101408709B1 (enExample)
CN (1) CN101346360A (enExample)
AR (1) AR058570A1 (enExample)
AU (1) AU2006326979B2 (enExample)
BR (1) BRPI0620204A2 (enExample)
CA (1) CA2631832C (enExample)
DE (1) DE102005061623A1 (enExample)
IL (1) IL192241A (enExample)
NZ (1) NZ569851A (enExample)
RU (1) RU2455292C2 (enExample)
TW (1) TWI391382B (enExample)
WO (1) WO2007071742A1 (enExample)
ZA (1) ZA200804030B (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030181488A1 (en) 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
DE10339862A1 (de) * 2003-08-29 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel
DE102005061624A1 (de) * 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verbessertes Verfahren zur Herstellung von Salzen von 4-(Benzimidazolylmethylamino)-Benzamidinen
DE102006054005A1 (de) * 2006-11-16 2008-05-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester
CZ305085B6 (cs) 2008-03-14 2015-04-29 Zentiva, K.S. Způsob přípravy dabigatranu
NZ586868A (en) * 2008-03-28 2012-02-24 Boehringer Ingelheim Int Process for preparing orally administered dabigatran formulations
US8471033B2 (en) * 2008-06-16 2013-06-25 Boehringer Ingelheim International Gmbh Method for producing an intermediate product of dabigatran etexilate
NZ589746A (en) * 2008-07-14 2012-10-26 Boehringer Ingelheim Int Method for manufacturing medicinal compounds containing dabigatran
CZ2008669A3 (cs) * 2008-10-24 2010-05-05 Zentiva, A. S. Zpusob prípravy dabigatranu a jeho meziprodukty
NZ592616A (en) 2008-11-11 2013-04-26 Boehringer Ingelheim Int Method for treating or preventing thrombosis using dabigatran etexilate or a salt thereof with improved safety profile over conventional warfarin therapy
US8399678B2 (en) * 2009-11-18 2013-03-19 Boehringer Ingelheim International Gmbh Process for the manufacture of dabigatran etexilate
HUP1000069A2 (en) * 2010-02-02 2012-05-02 Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag New salts for the preparation of pharmaceutical composition
WO2012077136A2 (en) * 2010-12-06 2012-06-14 Msn Laboratories Limited Process for the preparation of benzimidazole derivatives and its salts
HUP1100244A2 (hu) 2011-05-11 2012-11-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Gyógyszeripari intermedierek és eljárás elõállításukra
EP2522662A1 (en) 2011-05-11 2012-11-14 Medichem, S.A. Dabigatran etexilate and related substances, processes and compositions, and use of the substances as reference standards and markers
CN102993175B (zh) * 2011-09-08 2014-08-13 天津药物研究院 达比加群的酯衍生物及其制备方法和用途
WO2013111163A2 (en) * 2012-01-20 2013-08-01 Cadila Healthcare Limited Process for the preparation of dabigatran etexilate mesylate and polymorphs of intermediates thereof
EP2631234A1 (en) * 2012-02-23 2013-08-28 Esteve Química, S.A. Solid forms of dabigatran etexilate mesylate and processes for their preparation
EP2834224B1 (en) 2012-04-02 2018-06-06 MSN Laboratories Limited Process for the preparation of benzimidazole derivatives and salts thereof
CN102850325B (zh) * 2012-06-19 2014-03-26 上海现代制药海门有限公司 一种达比加群酯关键中间体的制备方法
CN102850326B (zh) * 2012-06-19 2014-04-09 上海现代制药股份有限公司 一种达比加群酯中间体及其制备方法和应用
CN102850327B (zh) * 2012-06-19 2014-07-16 上海现代制药股份有限公司 一种制备达比加群酯的中间体及其制备方法和应用
EP2872500A4 (en) * 2012-07-12 2016-03-30 Rao Davuluri Ramamohan IMPROVED METHOD FOR THE PRODUCTION OF DABIGATRANETEXILATE MESYLATE AND INTERMEDIATE PRODUCTS THEREOF
EP2890692A1 (en) 2012-08-31 2015-07-08 Ranbaxy Laboratories Limited Process for the preparation of crystalline form i of methanesulfonate salt of dabigatran etexilate
US10077251B2 (en) 2012-10-29 2018-09-18 Biophore India Pharmaceuticals Pvt. Ltd. Process for the synthesis of Dabigatran Etexilate and its intermediates
US9533971B2 (en) 2012-10-29 2017-01-03 Biophore India Pharmaceuticals Pvt. Ltd Process for the synthesis of dabigatran and its intermediates
WO2014151929A1 (en) 2013-03-15 2014-09-25 Proteus Digital Health, Inc. Personal authentication apparatus system and method
EP2835370A1 (en) 2013-08-08 2015-02-11 Medichem, S.A. New crystals of dabigatran etexilate mesylate
CN104031031B (zh) * 2014-05-05 2017-01-11 南通常佑药业科技有限公司 一种制备达比加群酯的方法
CN103992241B (zh) * 2014-06-05 2016-08-24 雅本化学股份有限公司 N-取代苯基甘氨酸的制备方法
CN105461686A (zh) * 2014-08-25 2016-04-06 江苏豪森药业股份有限公司 制备高纯度甲磺酸达比加群酯晶型的方法
ES2712886T3 (es) 2014-09-24 2019-05-16 Bayer Pharma AG Derivados de piridobenzazepina y piridobenzazocina que inhiben el factor XIa
CN111253369A (zh) * 2018-11-30 2020-06-09 上海医药集团股份有限公司 一种苯磺酸盐、其制备方法及其在制备达比加群酯中的应用
CN111595828B (zh) * 2019-02-21 2022-10-14 香港科技大学深圳研究院 一种纳米氧化锌溶出的监测方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087380A (en) * 1949-11-24 2000-07-11 Boehringer Ingelheim Pharma Kg Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions
PE121699A1 (es) 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma Heterociclos biciclicos disustituidos como inhibidores de la trombina
TWI248435B (en) * 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
US6248770B1 (en) * 1998-07-09 2001-06-19 Boehringer Ingelheim Pharma Kg Benzimidazoles having antithrombotic activity
US6451832B2 (en) * 1999-12-23 2002-09-17 Boehringer Ingelheim Pharma Kg Benzimidazoles with antithrombotic activity
DE19962329A1 (de) * 1999-12-23 2001-06-28 Boehringer Ingelheim Pharma Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel
PT1870100E (pt) * 2002-03-07 2012-04-17 Boehringer Ingelheim Int Metanossulfonato de 3-[(2-{[4-(hexiloxicarbonilamino-iminometil)- fenilamino]-metil}-1-metil-1h-benzimidazol-5-carbonil)- piridin-2-il-amino]-propionato de etilo
EP1609784A1 (de) * 2004-06-25 2005-12-28 Boehringer Ingelheim Pharma GmbH & Co.KG Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen
DE102005061624A1 (de) 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verbessertes Verfahren zur Herstellung von Salzen von 4-(Benzimidazolylmethylamino)-Benzamidinen
EP1956018A1 (de) 2007-02-06 2008-08-13 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung eines Benzimidazolderivats
NZ586868A (en) 2008-03-28 2012-02-24 Boehringer Ingelheim Int Process for preparing orally administered dabigatran formulations
US20120276206A1 (en) 2008-03-28 2012-11-01 Boehringer Ingelheim International Gmbh Method for manufacturing acid pellets
US8471033B2 (en) 2008-06-16 2013-06-25 Boehringer Ingelheim International Gmbh Method for producing an intermediate product of dabigatran etexilate
JP5642670B2 (ja) 2008-06-16 2014-12-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ダビガトランの合成の中間体の製造方法
NZ589746A (en) 2008-07-14 2012-10-26 Boehringer Ingelheim Int Method for manufacturing medicinal compounds containing dabigatran

Similar Documents

Publication Publication Date Title
JP2009520765A5 (enExample)
JP2008503519A5 (enExample)
RU2008129376A (ru) Улучшенный способ получения 4-(бензимидазолилметиламино)-бензамидов и их солей
RU2008129637A (ru) Улучшенный способ получения солей 4-(бензимидазолилметиламино)-бензамидов
JP2012501296A5 (enExample)
RU2007102631A (ru) Способ получения 4-(бензимидазолилметилсмино) бензамидинов
JP2010510976A5 (enExample)
CN1262674A (zh) 3－或4－取代的4－(氨基甲基)－哌啶衍生物的胃动力单环苯甲酰胺
JP2009527517A5 (enExample)
ZA200710145B (en) Method for the production of 5-(4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl-benzofuran-2-carboxamide
JP2009501753A5 (enExample)
JP2006225406A5 (enExample)
CN101993405A (zh) 吲哚啉衍生物、及其制备方法和用途
HUT64320A (en) Process for production antiallergic imidazole derivatives and pharmaceutical preparations containing these compounds
CN1509282A (zh) 4-(苯基-哌啶-4-基亚基-甲基)-苯甲酰胺衍生物及其在治疗疼痛、焦虑或胃肠疾病中的用途
JP2006526587A5 (enExample)
US20100016601A1 (en) Process for preparing remifentanil, intermediates thereof, use of said intermediates and processes for the preparation thereof
JP2008528451A5 (enExample)
DE602006000226T2 (de) Verfahren zur Herstellung von Adapalene
US20100137613A1 (en) Process for eprosartan
JP7252978B2 (ja) ２－（１－（ｔｅｒｔ－ブトキシカルボニル）ピペリジン－４－イル）安息香酸を調製するためのプロセス
JP2011513358A5 (enExample)
CN1527828A (zh) 4-(苯基-哌啶-4-基亚基-甲基)-苯甲酰胺衍生物及其在治疗疼痛、焦虑或胃肠疾病中的用途
JP2003516383A5 (enExample)
JP2012500238A5 (enExample)