JP2008503519A5 - - Google Patents
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- Publication number
- JP2008503519A5 JP2008503519A5 JP2007517164A JP2007517164A JP2008503519A5 JP 2008503519 A5 JP2008503519 A5 JP 2008503519A5 JP 2007517164 A JP2007517164 A JP 2007517164A JP 2007517164 A JP2007517164 A JP 2007517164A JP 2008503519 A5 JP2008503519 A5 JP 2008503519A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- formula
- optionally substituted
- alkyl
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(c1ccc2[n](*)c(CNc(cc3)ccc3C(N)=[*+])nc2c1)=[C-] Chemical compound *C(c1ccc2[n](*)c(CNc(cc3)ccc3C(N)=[*+])nc2c1)=[C-] 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04014917A EP1609784A1 (de) | 2004-06-25 | 2004-06-25 | Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen |
| EP04014917.1 | 2004-06-25 | ||
| PCT/EP2005/006586 WO2006000353A1 (de) | 2004-06-25 | 2005-06-18 | Verfahren zur herstellung von 4-(benzimidazolylmethylamino)- benzamidinen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008503519A JP2008503519A (ja) | 2008-02-07 |
| JP2008503519A5 true JP2008503519A5 (enExample) | 2008-08-07 |
| JP5073486B2 JP5073486B2 (ja) | 2012-11-14 |
Family
ID=34925482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007517164A Expired - Lifetime JP5073486B2 (ja) | 2004-06-25 | 2005-06-18 | ４−（ベンズイミダゾリルメチルアミノ）−ベンズアミジンの製造方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7202368B2 (enExample) |
| EP (2) | EP1609784A1 (enExample) |
| JP (1) | JP5073486B2 (enExample) |
| KR (1) | KR101298507B1 (enExample) |
| CN (1) | CN1972919B (enExample) |
| AR (1) | AR049410A1 (enExample) |
| AU (1) | AU2005256424B2 (enExample) |
| BR (1) | BRPI0511318B8 (enExample) |
| CA (1) | CA2570499C (enExample) |
| DK (1) | DK1761510T3 (enExample) |
| ES (1) | ES2543982T3 (enExample) |
| HU (1) | HUE027198T2 (enExample) |
| IL (2) | IL180247A (enExample) |
| MX (1) | MXPA06015210A (enExample) |
| NZ (1) | NZ552809A (enExample) |
| PL (1) | PL1761510T3 (enExample) |
| RU (1) | RU2401264C2 (enExample) |
| TW (1) | TWI364417B (enExample) |
| WO (1) | WO2006000353A1 (enExample) |
| ZA (1) | ZA200609918B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030181488A1 (en) | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof |
| DE10339862A1 (de) * | 2003-08-29 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel |
| DE102005020002A1 (de) * | 2005-04-27 | 2006-11-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Physiologisch verträgliche Salze von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester |
| DE102005061624A1 (de) | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von Salzen von 4-(Benzimidazolylmethylamino)-Benzamidinen |
| DE102005061623A1 (de) * | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen |
| JP2010505906A (ja) * | 2006-10-10 | 2010-02-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ３−［（２−｛［４−（ヘキシルオキシカルボニルアミノ−イミノ−メチル）−フェニルアミノ］−メチル｝−１−メチル−１ｈ−ベンゾイミダゾール−５−カルボニル）−ピリジン−２−イル−アミノ］−プロピオン酸エチルエステルの生理学的に許容される塩 |
| DE102006054005A1 (de) * | 2006-11-16 | 2008-05-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester |
| EP1956018A1 (de) * | 2007-02-06 | 2008-08-13 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Herstellung eines Benzimidazolderivats |
| CZ305085B6 (cs) | 2008-03-14 | 2015-04-29 | Zentiva, K.S. | Způsob přípravy dabigatranu |
| AU2009228795B2 (en) * | 2008-03-28 | 2014-02-13 | Boehringer Ingelheim International Gmbh | Process for preparing orally administered dabigatran formulations |
| HUE025533T2 (en) * | 2008-06-16 | 2016-05-30 | Boehringer Ingelheim Int | A process for preparing an intermediate of dabigatran etexylate |
| BRPI0915942A2 (pt) * | 2008-07-14 | 2019-04-09 | Boehringer Ingelheim International Gmbh | método para produção de compostos medicinais contendo dabigatrana |
| CZ2008669A3 (cs) * | 2008-10-24 | 2010-05-05 | Zentiva, A. S. | Zpusob prípravy dabigatranu a jeho meziprodukty |
| CN102050814B (zh) * | 2009-11-06 | 2014-05-28 | 北京美倍他药物研究有限公司 | 达比加群的酯衍生物 |
| CN102050815B (zh) * | 2009-11-06 | 2014-04-02 | 北京美倍他药物研究有限公司 | 作为前药的达比加群的酯衍生物 |
| US8399678B2 (en) * | 2009-11-18 | 2013-03-19 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dabigatran etexilate |
| EP2590962A2 (en) | 2010-07-09 | 2013-05-15 | Esteve Química, S.A. | Process of preparing a thrombin specific inhibitor |
| WO2012004397A1 (en) | 2010-07-09 | 2012-01-12 | Esteve Química, S.A. | Intermediates and process for preparing a thrombin specific inhibitor |
| EP2603503B1 (en) | 2010-09-27 | 2015-08-05 | ratiopharm GmbH | Dabigatran etexilate bismesylate salt, solid state forms and process for preparation thereof |
| EP2649060B1 (en) | 2010-12-06 | 2017-04-05 | MSN Laboratories Limited | Process for the preparation of benzimidazole derivatives and its salts |
| EP2522662A1 (en) | 2011-05-11 | 2012-11-14 | Medichem, S.A. | Dabigatran etexilate and related substances, processes and compositions, and use of the substances as reference standards and markers |
| HUP1100244A2 (hu) | 2011-05-11 | 2012-11-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Gyógyszeripari intermedierek és eljárás elõállításukra |
| US9212166B2 (en) | 2012-01-20 | 2015-12-15 | Cadila Healthcare Limited | Process for the preparation of dabigatran etexilate mesylate and polymorphs of intermediates thereof |
| WO2013150545A2 (en) | 2012-04-02 | 2013-10-10 | Msn Laboratories Limited | Process for the preparation of benzimidazole derivatives and salts thereof |
| WO2014020555A2 (en) * | 2012-08-01 | 2014-02-06 | Alembic Pharmaceuticals Limited | An improved process for the preparation of dabigatran etexilate mesylate |
| IN2015DN02616A (enExample) * | 2012-09-28 | 2015-09-18 | Ranbaxy Lab Ltd | |
| US9399616B2 (en) | 2012-10-22 | 2016-07-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of 4-aminobenzoamidine dihydrochloride |
| WO2014068587A2 (en) * | 2012-10-29 | 2014-05-08 | Biophore India Pharmaceuticals Pvt. Ltd. | An improved process for the synthesis of dabigatran and its intermediates |
| US10077251B2 (en) | 2012-10-29 | 2018-09-18 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the synthesis of Dabigatran Etexilate and its intermediates |
| WO2014178017A1 (en) * | 2013-04-30 | 2014-11-06 | Ranbaxy Laboratories Limited | Dabigatran etexilate impurity, process of its preparation, and its use as a reference standard |
| EP2835370A1 (en) | 2013-08-08 | 2015-02-11 | Medichem, S.A. | New crystals of dabigatran etexilate mesylate |
| CN103626740B (zh) * | 2013-12-05 | 2015-02-04 | 南京欧信医药技术有限公司 | 一种化合物的合成方法 |
| CN103772358A (zh) * | 2014-01-07 | 2014-05-07 | 万特制药(海南)有限公司 | 一种制备达比加群酯的合成方法 |
| WO2015128875A2 (en) | 2014-02-26 | 2015-09-03 | Megafine Pharma (P) Ltd. | A process for preparation of dabigatran etexilate mesylate and intermediates thereof |
| CN105461686A (zh) * | 2014-08-25 | 2016-04-06 | 江苏豪森药业股份有限公司 | 制备高纯度甲磺酸达比加群酯晶型的方法 |
| CN104910047B (zh) * | 2015-05-11 | 2017-06-06 | 常州市阳光药业有限公司 | 达比加群酯中间体的制备方法 |
| EP3848998A4 (en) | 2018-10-29 | 2021-11-24 | LG Chem, Ltd. | SEPARATOR FOR ELECTROCHEMICAL DEVICE AND METHOD FOR MANUFACTURING IT |
| EP3771465A1 (en) | 2019-08-01 | 2021-02-03 | Zaklady Farmaceutyczne Polpharma SA | Pharmaceutical composition comprising dabigatran etexilate |
| CN116178252A (zh) * | 2022-07-26 | 2023-05-30 | 浙江海翔药业股份有限公司 | 一种甲磺酸达比加群酯的原料杂质及其制备方法和用途 |
| CN116354952A (zh) * | 2023-01-06 | 2023-06-30 | 宿迁盛基医药科技有限公司 | 一种达比加群酯关键中间体的合成工艺 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19516483A1 (de) * | 1995-05-05 | 1996-11-07 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
| PE121699A1 (es) * | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
| US6414008B1 (en) * | 1997-04-29 | 2002-07-02 | Boehringer Ingelheim Pharma Kg | Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions |
| TWI248435B (en) * | 1998-07-04 | 2006-02-01 | Boehringer Ingelheim Pharma | Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions |
| US6248770B1 (en) * | 1998-07-09 | 2001-06-19 | Boehringer Ingelheim Pharma Kg | Benzimidazoles having antithrombotic activity |
| DE19924818A1 (de) * | 1999-05-29 | 2000-11-30 | Bayer Ag | Substituierte Phenylcyclohexancarbonsäureamide |
| US6451832B2 (en) * | 1999-12-23 | 2002-09-17 | Boehringer Ingelheim Pharma Kg | Benzimidazoles with antithrombotic activity |
| DE19962329A1 (de) * | 1999-12-23 | 2001-06-28 | Boehringer Ingelheim Pharma | Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel |
| EP1574516A1 (en) * | 2004-03-05 | 2005-09-14 | Sanofi-Aventis | Antithrombotic compound |
-
2004
- 2004-06-25 EP EP04014917A patent/EP1609784A1/de not_active Withdrawn
-
2005
- 2005-06-09 US US11/149,021 patent/US7202368B2/en not_active Expired - Lifetime
- 2005-06-18 KR KR1020077001725A patent/KR101298507B1/ko not_active Expired - Lifetime
- 2005-06-18 RU RU2007102631/04A patent/RU2401264C2/ru active
- 2005-06-18 DK DK05769631.2T patent/DK1761510T3/en active
- 2005-06-18 BR BRPI0511318A patent/BRPI0511318B8/pt active IP Right Grant
- 2005-06-18 CN CN2005800209919A patent/CN1972919B/zh not_active Expired - Lifetime
- 2005-06-18 ES ES05769631.2T patent/ES2543982T3/es not_active Expired - Lifetime
- 2005-06-18 HU HUE05769631A patent/HUE027198T2/en unknown
- 2005-06-18 NZ NZ552809A patent/NZ552809A/en not_active IP Right Cessation
- 2005-06-18 MX MXPA06015210A patent/MXPA06015210A/es active IP Right Grant
- 2005-06-18 WO PCT/EP2005/006586 patent/WO2006000353A1/de not_active Ceased
- 2005-06-18 PL PL05769631T patent/PL1761510T3/pl unknown
- 2005-06-18 AU AU2005256424A patent/AU2005256424B2/en not_active Expired
- 2005-06-18 EP EP05769631.2A patent/EP1761510B1/de not_active Expired - Lifetime
- 2005-06-18 JP JP2007517164A patent/JP5073486B2/ja not_active Expired - Lifetime
- 2005-06-18 CA CA2570499A patent/CA2570499C/en not_active Expired - Lifetime
- 2005-06-24 TW TW094121340A patent/TWI364417B/zh not_active IP Right Cessation
- 2005-06-24 AR ARP050102596A patent/AR049410A1/es active IP Right Grant
-
2006
- 2006-11-28 ZA ZA200609918A patent/ZA200609918B/en unknown
- 2006-12-21 IL IL180247A patent/IL180247A/en active IP Right Grant
-
2007
- 2007-03-02 US US11/681,549 patent/US7459566B2/en not_active Expired - Lifetime
-
2011
- 2011-03-01 IL IL211491A patent/IL211491A/en active IP Right Grant
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