PL1761510T3 - Sposób wytwarzania 4-(benzimidazolilometyloamino)-benzamidyn - Google Patents
Sposób wytwarzania 4-(benzimidazolilometyloamino)-benzamidynInfo
- Publication number
- PL1761510T3 PL1761510T3 PL05769631T PL05769631T PL1761510T3 PL 1761510 T3 PL1761510 T3 PL 1761510T3 PL 05769631 T PL05769631 T PL 05769631T PL 05769631 T PL05769631 T PL 05769631T PL 1761510 T3 PL1761510 T3 PL 1761510T3
- Authority
- PL
- Poland
- Prior art keywords
- benzimidazolylmethylamino
- benzamidines
- producing
- Prior art date
Links
- MAJHTLSEWVGZNC-UHFFFAOYSA-N 4-(1h-benzimidazol-2-ylmethylamino)benzenecarboximidamide Chemical class C1=CC(C(=N)N)=CC=C1NCC1=NC2=CC=CC=C2N1 MAJHTLSEWVGZNC-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04014917A EP1609784A1 (de) | 2004-06-25 | 2004-06-25 | Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen |
| PCT/EP2005/006586 WO2006000353A1 (de) | 2004-06-25 | 2005-06-18 | Verfahren zur herstellung von 4-(benzimidazolylmethylamino)- benzamidinen |
| EP05769631.2A EP1761510B1 (de) | 2004-06-25 | 2005-06-18 | Verfahren zur herstellung von 4-(benzimidazolylmethylamino)- benzamidinen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1761510T3 true PL1761510T3 (pl) | 2015-10-30 |
Family
ID=34925482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05769631T PL1761510T3 (pl) | 2004-06-25 | 2005-06-18 | Sposób wytwarzania 4-(benzimidazolilometyloamino)-benzamidyn |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7202368B2 (pl) |
| EP (2) | EP1609784A1 (pl) |
| JP (1) | JP5073486B2 (pl) |
| KR (1) | KR101298507B1 (pl) |
| CN (1) | CN1972919B (pl) |
| AR (1) | AR049410A1 (pl) |
| AU (1) | AU2005256424B2 (pl) |
| BR (1) | BRPI0511318B8 (pl) |
| CA (1) | CA2570499C (pl) |
| DK (1) | DK1761510T3 (pl) |
| ES (1) | ES2543982T3 (pl) |
| HU (1) | HUE027198T2 (pl) |
| IL (2) | IL180247A (pl) |
| MX (1) | MXPA06015210A (pl) |
| NZ (1) | NZ552809A (pl) |
| PL (1) | PL1761510T3 (pl) |
| RU (1) | RU2401264C2 (pl) |
| TW (1) | TWI364417B (pl) |
| WO (1) | WO2006000353A1 (pl) |
| ZA (1) | ZA200609918B (pl) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030181488A1 (en) * | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof |
| DE10339862A1 (de) * | 2003-08-29 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel |
| DE102005020002A1 (de) * | 2005-04-27 | 2006-11-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Physiologisch verträgliche Salze von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester |
| DE102005061623A1 (de) * | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen |
| DE102005061624A1 (de) | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von Salzen von 4-(Benzimidazolylmethylamino)-Benzamidinen |
| CA2666396A1 (en) * | 2006-10-10 | 2008-04-17 | Boehringer Ingelheim International Gmbh | Physiologically acceptable salts of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1h-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester |
| DE102006054005A1 (de) * | 2006-11-16 | 2008-05-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester |
| EP1956018A1 (de) * | 2007-02-06 | 2008-08-13 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Herstellung eines Benzimidazolderivats |
| CZ305085B6 (cs) * | 2008-03-14 | 2015-04-29 | Zentiva, K.S. | Způsob přípravy dabigatranu |
| KR20100129281A (ko) * | 2008-03-28 | 2010-12-08 | 베링거 인겔하임 인터내셔날 게엠베하 | 경구 투여되는 다비가트란 제형의 제조 방법 |
| AU2009259440B2 (en) * | 2008-06-16 | 2014-05-29 | Boehringer Ingelheim International Gmbh | Method for producing an intermediate product of dabigatran etexilate |
| TWI436994B (zh) * | 2008-07-14 | 2014-05-11 | Boehringer Ingelheim Int | 製備含有達比加群（ｄａｂｉｇａｔｒａｎ）之藥物組合物的新穎方法 |
| CZ2008669A3 (cs) * | 2008-10-24 | 2010-05-05 | Zentiva, A. S. | Zpusob prípravy dabigatranu a jeho meziprodukty |
| CN102050814B (zh) * | 2009-11-06 | 2014-05-28 | 北京美倍他药物研究有限公司 | 达比加群的酯衍生物 |
| CN102050815B (zh) * | 2009-11-06 | 2014-04-02 | 北京美倍他药物研究有限公司 | 作为前药的达比加群的酯衍生物 |
| US8399678B2 (en) * | 2009-11-18 | 2013-03-19 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dabigatran etexilate |
| JP2013531004A (ja) | 2010-07-09 | 2013-08-01 | エステヴェ キミカ， エス．エー． | トロンビン特異的インヒビターの調製のための中間体及び方法 |
| JP2013532164A (ja) | 2010-07-09 | 2013-08-15 | エステヴェ キミカ， エス．エー． | トロンビン特異的インヒビターを調製する方法 |
| PL2603503T3 (pl) | 2010-09-27 | 2015-12-31 | Ratiopharm Gmbh | Sól bismesylanowa eteksylanu dabigatranu, postacie stałe i sposób ich otrzymywania |
| WO2012077136A2 (en) * | 2010-12-06 | 2012-06-14 | Msn Laboratories Limited | Process for the preparation of benzimidazole derivatives and its salts |
| HUP1100244A2 (hu) | 2011-05-11 | 2012-11-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Gyógyszeripari intermedierek és eljárás elõállításukra |
| EP2522662A1 (en) | 2011-05-11 | 2012-11-14 | Medichem, S.A. | Dabigatran etexilate and related substances, processes and compositions, and use of the substances as reference standards and markers |
| WO2013111163A2 (en) | 2012-01-20 | 2013-08-01 | Cadila Healthcare Limited | Process for the preparation of dabigatran etexilate mesylate and polymorphs of intermediates thereof |
| US9273030B2 (en) | 2012-04-02 | 2016-03-01 | Msn Laboratories Private Limited | Process for the preparation of benzimidazole derivatives and salts thereof |
| WO2014020555A2 (en) * | 2012-08-01 | 2014-02-06 | Alembic Pharmaceuticals Limited | An improved process for the preparation of dabigatran etexilate mesylate |
| WO2014049585A2 (en) * | 2012-09-28 | 2014-04-03 | Ranbaxy Laboratories Limited | Process for the preparation of dabigatran etexilate or pharmaceutically acceptable salt thereof |
| US9399616B2 (en) | 2012-10-22 | 2016-07-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of 4-aminobenzoamidine dihydrochloride |
| US10077251B2 (en) | 2012-10-29 | 2018-09-18 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the synthesis of Dabigatran Etexilate and its intermediates |
| WO2014068587A2 (en) * | 2012-10-29 | 2014-05-08 | Biophore India Pharmaceuticals Pvt. Ltd. | An improved process for the synthesis of dabigatran and its intermediates |
| WO2014178017A1 (en) * | 2013-04-30 | 2014-11-06 | Ranbaxy Laboratories Limited | Dabigatran etexilate impurity, process of its preparation, and its use as a reference standard |
| EP2835370A1 (en) | 2013-08-08 | 2015-02-11 | Medichem, S.A. | New crystals of dabigatran etexilate mesylate |
| CN103626740B (zh) * | 2013-12-05 | 2015-02-04 | 南京欧信医药技术有限公司 | 一种化合物的合成方法 |
| CN103772358A (zh) * | 2014-01-07 | 2014-05-07 | 万特制药(海南)有限公司 | 一种制备达比加群酯的合成方法 |
| IN2014MU00675A (pl) | 2014-02-26 | 2015-10-23 | Megafine Pharma P Ltd | |
| CN105461686A (zh) * | 2014-08-25 | 2016-04-06 | 江苏豪森药业股份有限公司 | 制备高纯度甲磺酸达比加群酯晶型的方法 |
| CN104910047B (zh) * | 2015-05-11 | 2017-06-06 | 常州市阳光药业有限公司 | 达比加群酯中间体的制备方法 |
| CN112385076A (zh) | 2018-10-29 | 2021-02-19 | 株式会社Lg化学 | 用于电化学装置的隔板和制造该隔板的方法 |
| EP3771465A1 (en) | 2019-08-01 | 2021-02-03 | Zaklady Farmaceutyczne Polpharma SA | Pharmaceutical composition comprising dabigatran etexilate |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19516483A1 (de) | 1995-05-05 | 1996-11-07 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
| PE121699A1 (es) * | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
| US6414008B1 (en) * | 1997-04-29 | 2002-07-02 | Boehringer Ingelheim Pharma Kg | Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions |
| TWI248435B (en) * | 1998-07-04 | 2006-02-01 | Boehringer Ingelheim Pharma | Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions |
| US6248770B1 (en) | 1998-07-09 | 2001-06-19 | Boehringer Ingelheim Pharma Kg | Benzimidazoles having antithrombotic activity |
| DE19962329A1 (de) * | 1999-12-23 | 2001-06-28 | Boehringer Ingelheim Pharma | Benzimidazole, deren Herstellung und deren Verwendung als Arzneimittel |
| US6451832B2 (en) | 1999-12-23 | 2002-09-17 | Boehringer Ingelheim Pharma Kg | Benzimidazoles with antithrombotic activity |
| EP1574516A1 (en) * | 2004-03-05 | 2005-09-14 | Sanofi-Aventis | Antithrombotic compound |
-
2004
- 2004-06-25 EP EP04014917A patent/EP1609784A1/de not_active Withdrawn
-
2005
- 2005-06-09 US US11/149,021 patent/US7202368B2/en active Active
- 2005-06-18 PL PL05769631T patent/PL1761510T3/pl unknown
- 2005-06-18 DK DK05769631.2T patent/DK1761510T3/en active
- 2005-06-18 NZ NZ552809A patent/NZ552809A/en unknown
- 2005-06-18 EP EP05769631.2A patent/EP1761510B1/de active Active
- 2005-06-18 KR KR1020077001725A patent/KR101298507B1/ko active IP Right Grant
- 2005-06-18 JP JP2007517164A patent/JP5073486B2/ja active Active
- 2005-06-18 ES ES05769631.2T patent/ES2543982T3/es active Active
- 2005-06-18 CN CN2005800209919A patent/CN1972919B/zh active Active
- 2005-06-18 MX MXPA06015210A patent/MXPA06015210A/es active IP Right Grant
- 2005-06-18 WO PCT/EP2005/006586 patent/WO2006000353A1/de active Application Filing
- 2005-06-18 HU HUE05769631A patent/HUE027198T2/en unknown
- 2005-06-18 RU RU2007102631/04A patent/RU2401264C2/ru active
- 2005-06-18 CA CA2570499A patent/CA2570499C/en active Active
- 2005-06-18 BR BRPI0511318A patent/BRPI0511318B8/pt active IP Right Grant
- 2005-06-18 AU AU2005256424A patent/AU2005256424B2/en active Active
- 2005-06-24 AR ARP050102596A patent/AR049410A1/es active IP Right Grant
- 2005-06-24 TW TW094121340A patent/TWI364417B/zh active
-
2006
- 2006-11-28 ZA ZA200609918A patent/ZA200609918B/en unknown
- 2006-12-21 IL IL180247A patent/IL180247A/en active IP Right Grant
-
2007
- 2007-03-02 US US11/681,549 patent/US7459566B2/en active Active
-
2011
- 2011-03-01 IL IL211491A patent/IL211491A/en active IP Right Grant
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