CN102850326B - 一种达比加群酯中间体及其制备方法和应用 - Google Patents
一种达比加群酯中间体及其制备方法和应用 Download PDFInfo
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- CN102850326B CN102850326B CN201210203996.7A CN201210203996A CN102850326B CN 102850326 B CN102850326 B CN 102850326B CN 201210203996 A CN201210203996 A CN 201210203996A CN 102850326 B CN102850326 B CN 102850326B
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- 0 CC1C(*C(C)=C)=C=C=C(*)C1 Chemical compound CC1C(*C(C)=C)=C=C=C(*)C1 0.000 description 5
- DXUTWLTWGKEWJA-UHFFFAOYSA-N CCOC(CC(COCc1ccccc1)=O)=O Chemical compound CCOC(CC(COCc1ccccc1)=O)=O DXUTWLTWGKEWJA-UHFFFAOYSA-N 0.000 description 1
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CN201210203996.7A CN102850326B (zh) | 2012-06-19 | 2012-06-19 | 一种达比加群酯中间体及其制备方法和应用 |
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CN102850326B true CN102850326B (zh) | 2014-04-09 |
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WO2014167577A2 (en) * | 2013-03-25 | 2014-10-16 | Usv Limited | "synthesis of dabigatran" |
CN104003977B (zh) * | 2014-06-05 | 2016-04-13 | 雅本化学股份有限公司 | N-(2-氯甲基-1-甲基-1h-苯并咪唑-5-酰基)-n-(吡啶-2-基) -3-氨基丙酸乙酯的制备方法 |
CN107365299B (zh) * | 2017-03-09 | 2020-04-21 | 罗欣药业(上海)有限公司 | 一种达比加群酯的制备方法及其中间体 |
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DE102005061623A1 (de) * | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen |
AU2009259440B2 (en) * | 2008-06-16 | 2014-05-29 | Boehringer Ingelheim International Gmbh | Method for producing an intermediate product of dabigatran etexilate |
US8399678B2 (en) * | 2009-11-18 | 2013-03-19 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dabigatran etexilate |
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Inventor after: Hou Jian Inventor after: Zou Qiang Inventor after: Wang Guoping Inventor before: Zou Qiang Inventor before: Wang Guoping Inventor before: Hou Jian |
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Free format text: CORRECT: INVENTOR; FROM: ZOU QIANG WANG GUOPING HOU JIAN TO: HOU JIAN ZOU QIANG WANG GUOPING |
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Effective date of registration: 20181224 Address after: 037300 First Pharmaceutical Park, Datong Economic and Technological Development Zone, Shanxi Province Patentee after: Weiqida Pharmaceutical Co., Ltd. of China National Pharmaceutical Industry Corporation Ltd. Address before: 200137, Shanghai, Pudong New Area built 378 land Co-patentee before: Shanghai Shyndec Pharmaceutical Co., Ltd Patentee before: Shanghai Modern Pharmaceutical Co., Ltd. |
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