JP2009513143A5 - - Google Patents
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- Publication number
- JP2009513143A5 JP2009513143A5 JP2008538095A JP2008538095A JP2009513143A5 JP 2009513143 A5 JP2009513143 A5 JP 2009513143A5 JP 2008538095 A JP2008538095 A JP 2008538095A JP 2008538095 A JP2008538095 A JP 2008538095A JP 2009513143 A5 JP2009513143 A5 JP 2009513143A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell culture
- pdx1
- endoderm cells
- express
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000004113 cell culture Methods 0.000 claims 19
- 210000004039 endoderm cell Anatomy 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 108700011804 pancreatic and duodenal homeobox 1 Proteins 0.000 claims 10
- 210000005260 human cell Anatomy 0.000 claims 9
- 239000003102 growth factor Substances 0.000 claims 7
- 210000002438 upper gastrointestinal tract Anatomy 0.000 claims 7
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 6
- 229930002330 retinoic acid Natural products 0.000 claims 6
- 229960001727 tretinoin Drugs 0.000 claims 6
- 239000003550 marker Substances 0.000 claims 5
- 150000004492 retinoid derivatives Chemical class 0.000 claims 4
- 102100022123 Hepatocyte nuclear factor 1-beta Human genes 0.000 claims 3
- 102100029283 Hepatocyte nuclear factor 3-alpha Human genes 0.000 claims 3
- 102100029087 Hepatocyte nuclear factor 6 Human genes 0.000 claims 3
- 101001045758 Homo sapiens Hepatocyte nuclear factor 1-beta Proteins 0.000 claims 3
- 101001062353 Homo sapiens Hepatocyte nuclear factor 3-alpha Proteins 0.000 claims 3
- 101000988619 Homo sapiens Hepatocyte nuclear factor 6 Proteins 0.000 claims 3
- 101001069749 Homo sapiens Prospero homeobox protein 1 Proteins 0.000 claims 3
- 101000652324 Homo sapiens Transcription factor SOX-17 Proteins 0.000 claims 3
- 101000711846 Homo sapiens Transcription factor SOX-9 Proteins 0.000 claims 3
- 102100033880 Prospero homeobox protein 1 Human genes 0.000 claims 3
- 102100030243 Transcription factor SOX-17 Human genes 0.000 claims 3
- 102100034204 Transcription factor SOX-9 Human genes 0.000 claims 3
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 3
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 102100028071 Fibroblast growth factor 7 Human genes 0.000 claims 2
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 claims 2
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 2
- 238000012606 in vitro cell culture Methods 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000009278 visceral effect Effects 0.000 claims 2
- 102100028096 Homeobox protein Nkx-6.2 Human genes 0.000 claims 1
- 101000578254 Homo sapiens Homeobox protein Nkx-6.1 Proteins 0.000 claims 1
- 101000578258 Homo sapiens Homeobox protein Nkx-6.2 Proteins 0.000 claims 1
- 101000979321 Homo sapiens Neurofilament medium polypeptide Proteins 0.000 claims 1
- 101000652332 Homo sapiens Transcription factor SOX-1 Proteins 0.000 claims 1
- 101000642523 Homo sapiens Transcription factor SOX-7 Proteins 0.000 claims 1
- 101000976653 Homo sapiens Zinc finger protein ZIC 1 Proteins 0.000 claims 1
- 102100023055 Neurofilament medium polypeptide Human genes 0.000 claims 1
- 102100030248 Transcription factor SOX-1 Human genes 0.000 claims 1
- 102100036730 Transcription factor SOX-7 Human genes 0.000 claims 1
- 102100023497 Zinc finger protein ZIC 1 Human genes 0.000 claims 1
- 108010023082 activin A Proteins 0.000 claims 1
- 238000003365 immunocytochemistry Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000003753 real-time PCR Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73091705P | 2005-10-27 | 2005-10-27 | |
| US60/730,917 | 2005-10-27 | ||
| PCT/US2006/042413 WO2007051038A2 (en) | 2005-10-27 | 2006-10-27 | Pdx1-expressing dorsal and ventral foregut endoderm |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013141267A Division JP5968270B2 (ja) | 2005-10-27 | 2013-07-05 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009513143A JP2009513143A (ja) | 2009-04-02 |
| JP2009513143A5 true JP2009513143A5 (enExample) | 2009-08-13 |
| JP5404047B2 JP5404047B2 (ja) | 2014-01-29 |
Family
ID=37769419
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538095A Active JP5404047B2 (ja) | 2005-10-27 | 2006-10-27 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2013141267A Active JP5968270B2 (ja) | 2005-10-27 | 2013-07-05 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2015091898A Active JP6077046B2 (ja) | 2005-10-27 | 2015-04-28 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2016229718A Active JP6366115B2 (ja) | 2005-10-27 | 2016-11-28 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2018097236A Active JP6595041B2 (ja) | 2005-10-27 | 2018-05-21 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013141267A Active JP5968270B2 (ja) | 2005-10-27 | 2013-07-05 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2015091898A Active JP6077046B2 (ja) | 2005-10-27 | 2015-04-28 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2016229718A Active JP6366115B2 (ja) | 2005-10-27 | 2016-11-28 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2018097236A Active JP6595041B2 (ja) | 2005-10-27 | 2018-05-21 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US20070122905A1 (enExample) |
| EP (3) | EP3584311A1 (enExample) |
| JP (5) | JP5404047B2 (enExample) |
| CN (1) | CN101351547A (enExample) |
| AU (1) | AU2006305879B2 (enExample) |
| CA (2) | CA2869687C (enExample) |
| DK (2) | DK1957636T3 (enExample) |
| ES (2) | ES2743202T3 (enExample) |
| PL (1) | PL1957636T3 (enExample) |
| WO (1) | WO2007051038A2 (enExample) |
Families Citing this family (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7432104B2 (en) * | 2001-08-06 | 2008-10-07 | Bresgen Inc. | Methods for the culture of human embryonic stem cells on human feeder cells |
| US20050266554A1 (en) | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| US7541185B2 (en) * | 2003-12-23 | 2009-06-02 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| CN103898045B (zh) | 2003-12-23 | 2019-02-01 | 维亚希特公司 | 定形内胚层 |
| US8647873B2 (en) | 2004-04-27 | 2014-02-11 | Viacyte, Inc. | PDX1 expressing endoderm |
| US20090010900A1 (en) * | 2004-07-07 | 2009-01-08 | The University Of North Carlolina At Chapel Hill | Embryonic Stem Cell Derivatives, and Methods of Making and Using the Same |
| US8187878B2 (en) * | 2004-08-13 | 2012-05-29 | University Of Georgia Research Foundation, Inc. | Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors |
| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| AU2006255183B2 (en) | 2005-06-08 | 2012-02-02 | Centocor, Inc. | A cellular therapy for ocular degeneration |
| EP3584311A1 (en) * | 2005-10-27 | 2019-12-25 | Viacyte, Inc. | Pdx-1 expressing dorsal and ventral foregut endoderm |
| DK2420565T3 (en) | 2006-02-23 | 2017-12-04 | Viacyte Inc | APPLICABLE COMPOSITIONS AND METHODS FOR CULTIVATING DIFFERENTIBLE CELLS |
| EP2650359B1 (en) | 2006-03-02 | 2022-05-04 | Viacyte, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
| US7695965B2 (en) | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
| US11254916B2 (en) | 2006-03-02 | 2022-02-22 | Viacyte, Inc. | Methods of making and using PDX1-positive pancreatic endoderm cells |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| WO2008013664A2 (en) | 2006-07-26 | 2008-01-31 | Cythera, Inc. | Methods of producing pancreatic hormones |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| ES2537578T3 (es) * | 2007-07-18 | 2015-06-09 | Lifescan, Inc. | Diferenciación de las células madre de embriones humanos |
| CA2695225C (en) | 2007-07-31 | 2021-06-01 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| US9005962B2 (en) * | 2007-08-24 | 2015-04-14 | The University Court Of The University Of Edinburgh | Regionalised endoderm cells and uses thereof |
| US9062290B2 (en) * | 2007-11-27 | 2015-06-23 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
| BRPI0908033A2 (pt) | 2008-02-21 | 2015-08-04 | Centocor Ortho Biotech Inc | Método placas de superfície modificada e composições para adesão, cultura e desprendimento de célula |
| US8338170B2 (en) | 2008-04-21 | 2012-12-25 | Viacyte, Inc. | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| US20090298178A1 (en) * | 2008-06-03 | 2009-12-03 | D Amour Kevin Allen | Growth factors for production of definitive endoderm |
| BRPI0914116A2 (pt) | 2008-06-30 | 2019-09-17 | Centocor Ortho Biotech Inc | diferenciação de células-tronco pluripotentes |
| EP2346988B1 (en) | 2008-10-31 | 2017-05-31 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
| BRPI0919883A2 (pt) | 2008-10-31 | 2015-08-11 | Centocor Ortho Biotech Inc | Diferenciação de células-tronco embrionárias humanas para a linhagem endócrina pancreática |
| US8895300B2 (en) | 2008-11-04 | 2014-11-25 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
| IL289685B2 (en) | 2008-11-04 | 2025-09-01 | Viacyte Inc | Stem cell pool suspension preparations and methods for their differentiation |
| US8008075B2 (en) | 2008-11-04 | 2011-08-30 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods of differentiation thereof |
| CN105349517B (zh) | 2008-11-14 | 2021-05-04 | 维赛特公司 | 源于人多能干细胞的胰腺细胞的包封 |
| ES2642070T3 (es) | 2008-11-20 | 2017-11-15 | Janssen Biotech, Inc. | Cultivo de células madre pluripotentes en microportadores |
| CN102257132B (zh) | 2008-11-20 | 2014-09-03 | 森托科尔奥索生物科技公司 | 用于在平面基底上进行细胞附着和培养的方法和组合物 |
| US9109245B2 (en) | 2009-04-22 | 2015-08-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| DK2421957T3 (da) * | 2009-04-22 | 2021-01-25 | Viacyte Inc | Cellesammensætninger afledt af dedifferentierede omprogrammerede celler |
| EP2435471A2 (en) * | 2009-05-29 | 2012-04-04 | Novo Nordisk A/S | INDUCED DERIVATION OF SPECIFIC ENDODERM FROM hPS CELL-DERIVED DEFINITIVE ENDODERM |
| AU2010276440B2 (en) * | 2009-07-20 | 2014-07-03 | Janssen Biotech Inc. | Differentiation of human embryonic stem cells |
| AU2010276402B2 (en) * | 2009-07-20 | 2014-07-03 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| BR112012001480A2 (pt) * | 2009-07-20 | 2015-09-01 | Janssen Biotech Inc | Diferenciação de células-tronco embriônicas humanas |
| WO2011079017A2 (en) | 2009-12-23 | 2011-06-30 | Centocor Ortho Biotech Inc. | Differentiation of human embryonic stem cells |
| EP2516626B1 (en) | 2009-12-23 | 2017-05-10 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| WO2011109279A2 (en) * | 2010-03-01 | 2011-09-09 | Centocor Ortho Biotech Inc. | Methods for purifying cells derived from pluripotent stem cells |
| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| EP3498825A1 (en) | 2010-05-12 | 2019-06-19 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| RU2673946C1 (ru) | 2010-08-31 | 2018-12-03 | Янссен Байотек, Инк. | Дифференцирование плюрипотентных стволовых клеток |
| US9506036B2 (en) | 2010-08-31 | 2016-11-29 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| ES2659393T3 (es) | 2010-08-31 | 2018-03-15 | Janssen Biotech, Inc. | Diferenciación de células madre embrionarias humanas |
| WO2012115619A1 (en) | 2011-02-21 | 2012-08-30 | Viacyte, Inc. | Loading system for an encapsulation device |
| EP2794857A4 (en) | 2011-12-22 | 2015-07-08 | Janssen Biotech Inc | DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS IN SINGLE INSULIN POSITIVE CELLS |
| HK1206058A1 (en) | 2012-03-07 | 2015-12-31 | Janssen Biotech, Inc. | Defined media for expansion and maintenance of pluripotent stem cells |
| WO2013176249A1 (ja) | 2012-05-25 | 2013-11-28 | 学校法人埼玉医科大学 | 膵臓ホルモン産生細胞の生産方法及び膵臓ホルモン産生細胞、並びに分化誘導促進剤 |
| ES2897649T3 (es) | 2012-06-08 | 2022-03-02 | Janssen Biotech Inc | Diferenciación de células madre embrionarias humanas en células endocrinas pancreáticas |
| AU2013248265B2 (en) | 2012-11-08 | 2018-11-01 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
| EP4219683A1 (en) | 2012-12-31 | 2023-08-02 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators |
| RU2687379C2 (ru) | 2012-12-31 | 2019-05-13 | Янссен Байотек, Инк. | Суспендирование и кластеризация плюрипотентных клеток человека с целью их дифференцировки в панкреатические эндокринные клетки |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| AU2013368221B2 (en) | 2012-12-31 | 2018-11-01 | Janssen Biotech, Inc. | Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells |
| US8859286B2 (en) | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
| EP2981605B1 (en) * | 2013-04-03 | 2019-06-19 | FUJIFILM Cellular Dynamics, Inc. | Methods and compositions for culturing endoderm progenitor cells in suspension |
| US9856304B2 (en) | 2013-05-24 | 2018-01-02 | Saitama Medical University | Peptide and application thereof |
| KR102341674B1 (ko) | 2013-06-11 | 2021-12-22 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | SC-β 세포 및 조성물 그리고 그 생성 방법 |
| EP2896688A1 (en) * | 2014-01-20 | 2015-07-22 | Centre National de la Recherche Scientifique (CNRS) | A method of producing beta pancreatic cells from progenitor cells through the use of hydrogen peroxide |
| US11051900B2 (en) | 2014-04-16 | 2021-07-06 | Viacyte, Inc. | Tools and instruments for use with implantable encapsulation devices |
| CA2949056C (en) | 2014-05-16 | 2025-10-07 | Janssen Biotech, Inc. | USE OF SMALL MOLECULES TO IMPROVE MAFA GENE EXPRESSION IN PANCREATIC ENDOCRINE CELLS |
| EP3149156B1 (en) | 2014-05-28 | 2021-02-17 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| EP3204489A4 (en) * | 2014-10-08 | 2018-09-05 | Agency for Science, Technology and Research | Methods of differentiating stem cells into liver cell lineages |
| US11584916B2 (en) | 2014-10-17 | 2023-02-21 | Children's Hospital Medical Center | Method of making in vivo human small intestine organoids from pluripotent stem cells |
| CN113234661A (zh) | 2014-12-18 | 2021-08-10 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
| US10190096B2 (en) | 2014-12-18 | 2019-01-29 | President And Fellows Of Harvard College | Methods for generating stem cell-derived β cells and uses thereof |
| KR102281752B1 (ko) * | 2014-12-19 | 2021-07-23 | 얀센 바이오테크 인코포레이티드 | 만능성 줄기 세포의 현탁 배양 |
| MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| CN116790476A (zh) | 2016-05-05 | 2023-09-22 | 儿童医院医疗中心 | 用于体外制造胃底组织的方法和与其相关的组合物 |
| KR102546194B1 (ko) | 2016-11-04 | 2023-06-21 | 칠드런즈 호스피탈 메디칼 센터 | 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법 |
| KR102558606B1 (ko) | 2016-12-05 | 2023-07-26 | 칠드런즈 호스피탈 메디칼 센터 | 결장 유사장기 및 이를 제조 및 사용하는 방법 |
| CN110234754B (zh) * | 2017-01-27 | 2024-02-20 | 株式会社钟化 | 内胚层细胞团、和由多能细胞制造三胚层中的任意胚层的细胞团的方法 |
| WO2018191673A1 (en) | 2017-04-14 | 2018-10-18 | Children's Hospital Medical Center | Multi donor stem cell compositions and methods of making same |
| EP3638205A4 (en) | 2017-06-14 | 2021-03-17 | Semma Therapeutics, Inc. | DEVICES AND METHODS FOR ADMINISTERING THERAPEUTICS |
| US10391156B2 (en) | 2017-07-12 | 2019-08-27 | Viacyte, Inc. | University donor cells and related methods |
| EP3694603A4 (en) | 2017-10-10 | 2021-07-14 | Children's Hospital Medical Center | ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF |
| KR102789149B1 (ko) | 2017-11-15 | 2025-03-31 | 셈마 테라퓨틱스, 인크. | 섬세포 제조 조성물 및 사용 방법 |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| JP7506657B2 (ja) | 2018-07-26 | 2024-06-26 | チルドレンズ ホスピタル メディカル センター | 肝胆膵組織およびその作製方法 |
| AU2019320072A1 (en) | 2018-08-10 | 2021-02-25 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| US12378572B2 (en) | 2018-09-07 | 2025-08-05 | Crispr Therapeutics Ag | Universal donor cells |
| US12428622B2 (en) | 2018-09-12 | 2025-09-30 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| BR112021023389A2 (pt) * | 2019-05-22 | 2022-02-01 | Cleveland Clinic Found | Geração de células de endoderma de intestino anterior dorsal e domínio anterior |
| JP7610533B2 (ja) | 2019-05-31 | 2025-01-08 | チルドレンズ ホスピタル メディカル センター | 造血幹細胞の生成および拡大方法 |
| WO2020243666A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| EP3976236A1 (en) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates Inc. | A biocompatible membrane composite |
| AU2020283056B2 (en) | 2019-05-31 | 2023-06-08 | Viacyte, Inc. | A biocompatible membrane composite |
| EP3976237A1 (en) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
| WO2021044377A1 (en) | 2019-09-05 | 2021-03-11 | Crispr Therapeutics Ag | Universal donor cells |
| US11118196B2 (en) | 2019-09-05 | 2021-09-14 | Crispr Therapeutics Ag | Universal donor cells |
| US11850303B2 (en) | 2020-10-27 | 2023-12-26 | Uqora, Inc. | Gel and a suppository and methods to provide the gel and suppository |
| WO2022144856A1 (en) | 2020-12-31 | 2022-07-07 | Crispr Therapeutics Ag | Universal donor cells |
| WO2024151541A1 (en) | 2023-01-09 | 2024-07-18 | Sana Biotechnology, Inc. | Type-1 diabetes autoimmune mouse |
| WO2024243236A2 (en) | 2023-05-22 | 2024-11-28 | Sana Biotechnology, Inc. | Methods of delivery of islet cells and related methods |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2161804A (en) | 1935-11-09 | 1939-06-13 | Baldwin Southwark Corp | Hydraulic press |
| US4873702A (en) | 1988-10-20 | 1989-10-10 | Chiu Ran Fun | Method and apparatus for DC restoration in digital receivers |
| US6165993A (en) * | 1992-03-23 | 2000-12-26 | University Of Massachusetts Medical Center | DNA vaccines against rotavirus infections |
| US5690926A (en) * | 1992-10-08 | 1997-11-25 | Vanderbilt University | Pluripotential embryonic cells and methods of making same |
| US5453357A (en) | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| US7153684B1 (en) * | 1992-10-08 | 2006-12-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US6015671A (en) * | 1995-06-07 | 2000-01-18 | Indiana University Foundation | Myocardial grafts and cellular compositions |
| US5874301A (en) * | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5748681A (en) | 1995-10-27 | 1998-05-05 | Lucent Technologies Inc | Offset correction for a homodyne radio |
| CA2247502A1 (en) | 1996-02-28 | 1997-09-04 | Vanderbilt University | Compositions and methods of making embryonic stem cells |
| US5877207A (en) * | 1996-03-11 | 1999-03-02 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| US5964261A (en) * | 1996-05-29 | 1999-10-12 | Baxter International Inc. | Implantation assembly |
| JP2001508302A (ja) | 1997-01-10 | 2001-06-26 | ライフ テクノロジーズ，インコーポレイテッド | 胚性幹細胞血清置換 |
| US5798644A (en) | 1997-02-20 | 1998-08-25 | At&T Corp | Method and apparatus for locating buried conveyances using locating & confirmation signals with an array of sensors |
| US5793230A (en) | 1997-02-26 | 1998-08-11 | Sandia Corporation | Sensor readout detector circuit |
| US6090622A (en) | 1997-03-31 | 2000-07-18 | The Johns Hopkins School Of Medicine | Human embryonic pluripotent germ cells |
| US6331406B1 (en) * | 1997-03-31 | 2001-12-18 | The John Hopkins University School Of Medicine | Human enbryonic germ cell and methods of use |
| US6261281B1 (en) | 1997-04-03 | 2001-07-17 | Electrofect As | Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells |
| BR9813202B1 (pt) | 1997-09-15 | 2011-11-01 | complexo de administração de genes; processo de transdução de células com material genético estranho, composição útil para administração de material genético e uso de um complexo de administração de genes. | |
| JP3880795B2 (ja) | 1997-10-23 | 2007-02-14 | ジェロン・コーポレーション | フィーダー細胞を含まない培養物中で、霊長類由来始原幹細胞を増殖させるための方法 |
| US20030008919A1 (en) * | 1999-06-03 | 2003-01-09 | Jean-Baptiste Roullet | Use of retinoids to treat high blood pressure and other cardiovascular disease |
| US6921811B2 (en) * | 1998-09-22 | 2005-07-26 | Biosurface Engineering Technologies, Inc. | Bioactive coating composition and methods |
| US6667176B1 (en) * | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| DE19852800C1 (de) | 1998-11-16 | 2000-04-13 | Univ Albert Ludwigs Freiburg | Verfahren zur Herstellung von Antikörpern gegen ein Polypeptid, von dem die kodierende Nukleinsäure bekannt ist |
| US6326201B1 (en) | 1999-02-10 | 2001-12-04 | Curis, Inc. | Pancreatic progenitor cells, methods and uses related thereto |
| US6872389B1 (en) * | 1999-07-08 | 2005-03-29 | Rhode Island Hospital | Liver stem cell |
| US7005252B1 (en) * | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
| US7256042B2 (en) * | 2000-04-27 | 2007-08-14 | Geron Corporation | Process for making hepatocytes from pluripotent stem cells |
| US6458589B1 (en) * | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
| US7045353B2 (en) | 2000-08-01 | 2006-05-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Directed differentiation of human embryonic cells |
| WO2002034880A2 (en) | 2000-10-23 | 2002-05-02 | University Of Kansas | Cadherin peptides for drug delivery and inhibition of tumor metastasis/invasion |
| CA2435826A1 (en) | 2001-01-24 | 2002-08-01 | The Government Of The United States Of America | Differentiation of stem cells to pancreatic endocrine cells |
| JP2004535425A (ja) * | 2001-06-13 | 2004-11-25 | マサチューセッツ インスティチュート オブ テクノロジー | ｉｎｖｉｖｏバイオリアクタ |
| EP1298201A1 (en) | 2001-09-27 | 2003-04-02 | Cardion AG | Process for the production of cells exhibiting an islet-beta-cell-like state |
| CA2463914A1 (en) * | 2001-10-18 | 2003-04-24 | Ixion Biotechnology, Inc. | Conversion of liver stem and progenitor cells to pancreatic functional cells |
| AU2002360424A1 (en) | 2001-11-26 | 2003-06-10 | Advanced Cell Technology, Inc. | Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells |
| US7157278B2 (en) * | 2001-12-04 | 2007-01-02 | Organogenesis, Inc. | Cultured cells from pancreatic islets |
| KR101008868B1 (ko) * | 2001-12-07 | 2011-01-17 | 제론 코포레이션 | 인간 배아 줄기세포 유래의 섬세포 |
| US20030138949A1 (en) * | 2001-12-12 | 2003-07-24 | Anil Bhushan | Methods for the regeneration of pancreatic islets and expansion of pancreatic endocrine cells |
| US20060003446A1 (en) * | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
| EP2361966A1 (en) * | 2002-05-17 | 2011-08-31 | Mount Sinai School of Medicine of New York University | Mesoderm and definitive endoderm cell populations |
| WO2003100026A2 (en) | 2002-05-28 | 2003-12-04 | Novocell, Inc. | Methods, compositions, and growth and differentiation factors for insulin-producing cells |
| AU2003273573A1 (en) * | 2002-05-28 | 2003-12-19 | Becton, Dickinson And Company | Expansion and transdifferentiation of human acinar cells |
| WO2004050827A2 (en) * | 2002-12-05 | 2004-06-17 | Technion Research & Development Foundation Ltd. | Cultured human pancreatic islets, and uses thereof |
| FR2849043B1 (fr) * | 2002-12-24 | 2005-07-08 | Gemac | Procede de fabrication d'un vecteur de molecules actives applicable dans le domaine de la diffusion de principes actifs et vecteur obtenu |
| CA2515108A1 (en) * | 2003-02-07 | 2004-08-26 | Wisconsin Alumni Research Foundation | Directed genetic modifications of human stem cells |
| US20070154981A1 (en) | 2003-02-14 | 2007-07-05 | The Board Of Trustees Of The Leland Stanford Junior University | Insulin-producing cells derived from stem cells |
| US20030224411A1 (en) * | 2003-03-13 | 2003-12-04 | Stanton Lawrence W. | Genes that are up- or down-regulated during differentiation of human embryonic stem cells |
| US20040229350A1 (en) | 2003-05-12 | 2004-11-18 | Nikolai Strelchenko | Morula derived embryonic stem cells |
| EP1627912A4 (en) | 2003-05-20 | 2007-12-12 | Riken | PREPARATION OF ENDODERMAL STEM CELLS |
| WO2005017131A2 (en) | 2003-08-14 | 2005-02-24 | THE GOUVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT F HEALTH AND HUMAN SERVICES | Methods for the differentiation of human stem cells |
| US20050170502A1 (en) | 2003-09-30 | 2005-08-04 | Regents Of The University Of California | Methods for maintaining hepatocytes in culture and for differentiating embryonic stem cells along a hepatocyte lineage |
| WO2007059007A2 (en) * | 2005-11-14 | 2007-05-24 | Cythera, Inc. | Markers of definitive endoderm |
| CN103898045B (zh) * | 2003-12-23 | 2019-02-01 | 维亚希特公司 | 定形内胚层 |
| US7625753B2 (en) * | 2003-12-23 | 2009-12-01 | Cythera, Inc. | Expansion of definitive endoderm cells |
| US7541185B2 (en) * | 2003-12-23 | 2009-06-02 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| US7985585B2 (en) * | 2004-07-09 | 2011-07-26 | Viacyte, Inc. | Preprimitive streak and mesendoderm cells |
| US20050266554A1 (en) * | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| JP2008500809A (ja) * | 2004-03-09 | 2008-01-17 | ライフスキャン・インコーポレイテッド | インスリン産生細胞を発生させるための方法 |
| WO2005097980A2 (en) | 2004-03-26 | 2005-10-20 | Geron Corporation | New protocols for making hepatocytes from embryonic stem cells |
| KR20070029681A (ko) * | 2004-04-01 | 2007-03-14 | 위스콘신 얼럼나이 리서어치 화운데이션 | 줄기 세포의 내배엽 및 이자 혈통으로의 분화 |
| EP2377922B1 (en) * | 2004-04-27 | 2020-04-08 | Viacyte, Inc. | PDX1 expressing endoderm |
| KR101395516B1 (ko) * | 2004-04-27 | 2014-05-14 | 비아싸이트, 인크. | Ｐｄｘ１ 발현 내배엽 |
| CA2573354C (en) | 2004-07-09 | 2015-02-24 | Cythera, Inc. | Preprimitive streak and mesendoderm cells |
| AU2005272078B2 (en) * | 2004-07-09 | 2011-04-14 | Viacyte, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| US8187878B2 (en) * | 2004-08-13 | 2012-05-29 | University Of Georgia Research Foundation, Inc. | Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors |
| JP2008514214A (ja) | 2004-09-29 | 2008-05-08 | セルアーティス アーベー | ヒト胚盤胞由来幹細胞（ｈＢＳ）から肝細胞様細胞を発生させる方法 |
| JP2008528038A (ja) | 2005-01-31 | 2008-07-31 | エス セル インターナショナル ピーティーイー リミテッド | 胚性幹細胞の指示された分化及びその利用 |
| CN100425694C (zh) | 2005-04-15 | 2008-10-15 | 北京大学 | 诱导胚胎干细胞向胰腺细胞分化的方法 |
| WO2007002210A2 (en) | 2005-06-20 | 2007-01-04 | Bresagen, Inc. | Embryonic stem cell culture compositions and methods of use thereof |
| US7732202B2 (en) * | 2005-10-21 | 2010-06-08 | International Stem Cell Corporation | Oxygen tension for the parthenogenic activation of human oocytes for the production of human embryonic stem cells |
| EP3584311A1 (en) | 2005-10-27 | 2019-12-25 | Viacyte, Inc. | Pdx-1 expressing dorsal and ventral foregut endoderm |
| GB0602063D0 (en) | 2006-02-02 | 2006-03-15 | Univ Manchester | Cell Culture |
| EP2650359B1 (en) * | 2006-03-02 | 2022-05-04 | Viacyte, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
| US7695965B2 (en) * | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
| WO2008013664A2 (en) * | 2006-07-26 | 2008-01-31 | Cythera, Inc. | Methods of producing pancreatic hormones |
| US20080241250A1 (en) * | 2006-11-08 | 2008-10-02 | Emans Pieter J | In vivo bioreactors and methods of making and using same |
| US7695963B2 (en) * | 2007-09-24 | 2010-04-13 | Cythera, Inc. | Methods for increasing definitive endoderm production |
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