JP2009513143A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009513143A5 JP2009513143A5 JP2008538095A JP2008538095A JP2009513143A5 JP 2009513143 A5 JP2009513143 A5 JP 2009513143A5 JP 2008538095 A JP2008538095 A JP 2008538095A JP 2008538095 A JP2008538095 A JP 2008538095A JP 2009513143 A5 JP2009513143 A5 JP 2009513143A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell culture
- pdx1
- endoderm cells
- express
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004113 cell culture Methods 0.000 claims 19
- 210000004039 endoderm cell Anatomy 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 108700011804 pancreatic and duodenal homeobox 1 Proteins 0.000 claims 10
- 210000005260 human cell Anatomy 0.000 claims 9
- 239000003102 growth factor Substances 0.000 claims 7
- 210000002438 upper gastrointestinal tract Anatomy 0.000 claims 7
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 6
- 229930002330 retinoic acid Natural products 0.000 claims 6
- 229960001727 tretinoin Drugs 0.000 claims 6
- 239000003550 marker Substances 0.000 claims 5
- 150000004492 retinoid derivatives Chemical class 0.000 claims 4
- 102100022123 Hepatocyte nuclear factor 1-beta Human genes 0.000 claims 3
- 102100029283 Hepatocyte nuclear factor 3-alpha Human genes 0.000 claims 3
- 102100029087 Hepatocyte nuclear factor 6 Human genes 0.000 claims 3
- 101001045758 Homo sapiens Hepatocyte nuclear factor 1-beta Proteins 0.000 claims 3
- 101001062353 Homo sapiens Hepatocyte nuclear factor 3-alpha Proteins 0.000 claims 3
- 101000988619 Homo sapiens Hepatocyte nuclear factor 6 Proteins 0.000 claims 3
- 101001069749 Homo sapiens Prospero homeobox protein 1 Proteins 0.000 claims 3
- 101000652324 Homo sapiens Transcription factor SOX-17 Proteins 0.000 claims 3
- 101000711846 Homo sapiens Transcription factor SOX-9 Proteins 0.000 claims 3
- 102100033880 Prospero homeobox protein 1 Human genes 0.000 claims 3
- 102100030243 Transcription factor SOX-17 Human genes 0.000 claims 3
- 102100034204 Transcription factor SOX-9 Human genes 0.000 claims 3
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 3
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 102100028071 Fibroblast growth factor 7 Human genes 0.000 claims 2
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 claims 2
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 2
- 238000012606 in vitro cell culture Methods 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000009278 visceral effect Effects 0.000 claims 2
- 102100028096 Homeobox protein Nkx-6.2 Human genes 0.000 claims 1
- 101000578254 Homo sapiens Homeobox protein Nkx-6.1 Proteins 0.000 claims 1
- 101000578258 Homo sapiens Homeobox protein Nkx-6.2 Proteins 0.000 claims 1
- 101000979321 Homo sapiens Neurofilament medium polypeptide Proteins 0.000 claims 1
- 101000652332 Homo sapiens Transcription factor SOX-1 Proteins 0.000 claims 1
- 101000642523 Homo sapiens Transcription factor SOX-7 Proteins 0.000 claims 1
- 101000976653 Homo sapiens Zinc finger protein ZIC 1 Proteins 0.000 claims 1
- 102100023055 Neurofilament medium polypeptide Human genes 0.000 claims 1
- 102100030248 Transcription factor SOX-1 Human genes 0.000 claims 1
- 102100036730 Transcription factor SOX-7 Human genes 0.000 claims 1
- 102100023497 Zinc finger protein ZIC 1 Human genes 0.000 claims 1
- 108010023082 activin A Proteins 0.000 claims 1
- 238000003365 immunocytochemistry Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000003753 real-time PCR Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73091705P | 2005-10-27 | 2005-10-27 | |
| US60/730,917 | 2005-10-27 | ||
| PCT/US2006/042413 WO2007051038A2 (en) | 2005-10-27 | 2006-10-27 | Pdx1-expressing dorsal and ventral foregut endoderm |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013141267A Division JP5968270B2 (ja) | 2005-10-27 | 2013-07-05 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009513143A JP2009513143A (ja) | 2009-04-02 |
| JP2009513143A5 true JP2009513143A5 (enExample) | 2009-08-13 |
| JP5404047B2 JP5404047B2 (ja) | 2014-01-29 |
Family
ID=37769419
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538095A Active JP5404047B2 (ja) | 2005-10-27 | 2006-10-27 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2013141267A Active JP5968270B2 (ja) | 2005-10-27 | 2013-07-05 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2015091898A Active JP6077046B2 (ja) | 2005-10-27 | 2015-04-28 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2016229718A Active JP6366115B2 (ja) | 2005-10-27 | 2016-11-28 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2018097236A Active JP6595041B2 (ja) | 2005-10-27 | 2018-05-21 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013141267A Active JP5968270B2 (ja) | 2005-10-27 | 2013-07-05 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2015091898A Active JP6077046B2 (ja) | 2005-10-27 | 2015-04-28 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2016229718A Active JP6366115B2 (ja) | 2005-10-27 | 2016-11-28 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
| JP2018097236A Active JP6595041B2 (ja) | 2005-10-27 | 2018-05-21 | Ｐｄｘ１発現背側及び腹側前腸内胚葉 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US20070122905A1 (enExample) |
| EP (3) | EP3584311A1 (enExample) |
| JP (5) | JP5404047B2 (enExample) |
| CN (1) | CN101351547A (enExample) |
| AU (1) | AU2006305879B2 (enExample) |
| CA (2) | CA2869687C (enExample) |
| DK (2) | DK1957636T3 (enExample) |
| ES (2) | ES2743202T3 (enExample) |
| PL (1) | PL1957636T3 (enExample) |
| WO (1) | WO2007051038A2 (enExample) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7432104B2 (en) * | 2001-08-06 | 2008-10-07 | Bresgen Inc. | Methods for the culture of human embryonic stem cells on human feeder cells |
| US20050266554A1 (en) | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| US8647873B2 (en) | 2004-04-27 | 2014-02-11 | Viacyte, Inc. | PDX1 expressing endoderm |
| US7541185B2 (en) * | 2003-12-23 | 2009-06-02 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| KR101221302B1 (ko) | 2003-12-23 | 2013-01-11 | 비아싸이트, 인크. | 완전 내배엽 |
| WO2006025937A2 (en) * | 2004-07-07 | 2006-03-09 | The University Of North Carolina At Chapel Hill | Embryonic stem cell derivatives, and methods of making and using the same |
| EP1791952A4 (en) * | 2004-08-13 | 2008-06-11 | Univ Georgia Res Found | COMPOSITIONS AND METHODS OF SELF-RENEWAL AND DIFFERENTIATION IN HUMAN EMBRYONAL STEM CELLS |
| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| CA2613889A1 (en) | 2005-06-08 | 2006-12-14 | Centocor, Inc. | A cellular therapy for ocular degeneration |
| EP3584311A1 (en) * | 2005-10-27 | 2019-12-25 | Viacyte, Inc. | Pdx-1 expressing dorsal and ventral foregut endoderm |
| EP1994141B1 (en) | 2006-02-23 | 2017-11-15 | ViaCyte, Inc. | Compositions and methods useful for culturing differentiable cells |
| US11254916B2 (en) | 2006-03-02 | 2022-02-22 | Viacyte, Inc. | Methods of making and using PDX1-positive pancreatic endoderm cells |
| CA2644468C (en) * | 2006-03-02 | 2022-02-01 | Cythera, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
| US7695965B2 (en) * | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| AU2007277364B2 (en) | 2006-07-26 | 2010-08-12 | Viacyte, Inc. | Methods of producing pancreatic hormones |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| BRPI0814425A2 (pt) * | 2007-07-18 | 2014-10-21 | Lifescan Inc | Diferenciação de células-tronco embrionárias humanas |
| CA3114827C (en) | 2007-07-31 | 2023-09-05 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| EP2195417A1 (en) * | 2007-08-24 | 2010-06-16 | University Court of the University of Edinburgh | Regionalised endoderm cells and uses thereof |
| CA2954431C (en) | 2007-11-27 | 2021-08-24 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
| RU2551772C2 (ru) | 2008-02-21 | 2015-05-27 | Сентокор Орто Байотек Инк. | Способы, поверхностно-модифицированные носители и композиции для иммобилизации, культивирования и открепления клеток |
| US8338170B2 (en) | 2008-04-21 | 2012-12-25 | Viacyte, Inc. | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| US20090298178A1 (en) * | 2008-06-03 | 2009-12-03 | D Amour Kevin Allen | Growth factors for production of definitive endoderm |
| AU2009267137A1 (en) | 2008-06-30 | 2010-01-07 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
| MX2011004565A (es) | 2008-10-31 | 2011-07-28 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico. |
| MX2011004563A (es) | 2008-10-31 | 2011-06-01 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico. |
| DK2356213T3 (da) | 2008-11-04 | 2019-09-09 | Viacyte Inc | Stamcelleaggregatsuspensionssammensætninger og fremgangsmåder til differentiering deraf |
| US8895300B2 (en) | 2008-11-04 | 2014-11-25 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
| US8008075B2 (en) | 2008-11-04 | 2011-08-30 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods of differentiation thereof |
| EP3363444B1 (en) | 2008-11-14 | 2022-09-14 | ViaCyte, Inc. | Encapsulation of pancreatic cells derived from human pluripotent stem cells |
| EP3260534A1 (en) | 2008-11-20 | 2017-12-27 | Janssen Biotech, Inc. | Pluripotent stem cell culture on micro-carriers |
| BRPI0921996A2 (pt) | 2008-11-20 | 2015-08-18 | Centocor Ortho Biotech Inc | Métodos e composições para cultura e ligação de células em substratos planos. |
| WO2010124142A2 (en) * | 2009-04-22 | 2010-10-28 | Cythera, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| US9109245B2 (en) | 2009-04-22 | 2015-08-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| EP2435471A2 (en) * | 2009-05-29 | 2012-04-04 | Novo Nordisk A/S | INDUCED DERIVATION OF SPECIFIC ENDODERM FROM hPS CELL-DERIVED DEFINITIVE ENDODERM |
| KR101786735B1 (ko) | 2009-07-20 | 2017-10-18 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| EP2456862A4 (en) * | 2009-07-20 | 2013-02-27 | Janssen Biotech Inc | DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS |
| KR101785626B1 (ko) * | 2009-07-20 | 2017-10-16 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| BR112012017761A2 (pt) | 2009-12-23 | 2015-09-15 | Centocor Ortho Biotech Inc | diferenciação das células-tronco embrionárias humanas |
| PH12012501254A1 (en) | 2009-12-23 | 2012-11-05 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| US9969981B2 (en) * | 2010-03-01 | 2018-05-15 | Janssen Biotech, Inc. | Methods for purifying cells derived from pluripotent stem cells |
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| RU2663339C1 (ru) | 2010-05-12 | 2018-08-03 | Янссен Байотек, Инк. | Дифференцирование эмбриональных стволовых клеток человека |
| JP6133776B2 (ja) | 2010-08-31 | 2017-05-24 | ヤンセン バイオテツク，インコーポレーテツド | 多能性幹細胞の分化 |
| KR101836850B1 (ko) | 2010-08-31 | 2018-03-09 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| CA2809300A1 (en) | 2010-08-31 | 2012-03-08 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| WO2012115619A1 (en) | 2011-02-21 | 2012-08-30 | Viacyte, Inc. | Loading system for an encapsulation device |
| AU2012355698B2 (en) | 2011-12-22 | 2018-11-29 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
| RU2018128383A (ru) | 2012-03-07 | 2019-03-14 | Янссен Байотек, Инк. | Среда определенного состава для размножения и обновления плюрипотентных стволовых клеток |
| US20150140661A1 (en) | 2012-05-25 | 2015-05-21 | Saitama Medical University | Method for producing pancreatic hormone-producing cell, pancreatic hormone-producing cell, and differentiation/induction promoter |
| RU2018108850A (ru) | 2012-06-08 | 2019-02-26 | Янссен Байотек, Инк. | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
| AU2013248265B2 (en) | 2012-11-08 | 2018-11-01 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
| MX2015008577A (es) | 2012-12-31 | 2015-09-07 | Janssen Biotech Inc | Cultivo de celulas madre embrionarias humanas en la interfase aire-liquido para la diferenciacion en celulas endocrinas pancreaticas. |
| SG10201707811XA (en) | 2012-12-31 | 2017-11-29 | Janssen Biotech Inc | Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators |
| EP4039798A1 (en) | 2012-12-31 | 2022-08-10 | Janssen Biotech, Inc. | Suspension and clustering of human pluripotent cells |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| US8859286B2 (en) | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
| US10266807B2 (en) | 2013-04-03 | 2019-04-23 | FUJIFILM Cellular Dynamics, Inc. | Methods and compositions for culturing endoderm progenitor cells in suspension |
| US9856304B2 (en) | 2013-05-24 | 2018-01-02 | Saitama Medical University | Peptide and application thereof |
| KR102423106B1 (ko) | 2013-06-11 | 2022-07-21 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | SC-β 세포 및 조성물 그리고 그 생성 방법 |
| EP2896688A1 (en) * | 2014-01-20 | 2015-07-22 | Centre National de la Recherche Scientifique (CNRS) | A method of producing beta pancreatic cells from progenitor cells through the use of hydrogen peroxide |
| US11051900B2 (en) | 2014-04-16 | 2021-07-06 | Viacyte, Inc. | Tools and instruments for use with implantable encapsulation devices |
| KR102162138B1 (ko) | 2014-05-16 | 2020-10-06 | 얀센 바이오테크 인코포레이티드 | 췌장 내분비 세포에서 mafa 발현을 향상시키기 위한 소분자의 용도 |
| EP3149156B1 (en) | 2014-05-28 | 2021-02-17 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| EP3204489A4 (en) * | 2014-10-08 | 2018-09-05 | Agency for Science, Technology and Research | Methods of differentiating stem cells into liver cell lineages |
| JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法 |
| WO2016100909A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
| WO2016100930A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived b cells and methods of use thereof |
| WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
| SG11201704961VA (en) * | 2014-12-19 | 2017-07-28 | Janssen Biotech Inc | Suspension culturing of pluripotent stem cells |
| MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| EP4177335A1 (en) | 2016-05-05 | 2023-05-10 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
| EP3534976A4 (en) | 2016-11-04 | 2020-09-16 | Children's Hospital Medical Center | PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| EP3587560A4 (en) | 2017-01-27 | 2020-12-16 | Kaneka Corporation | Endodermal cell mass, and method for producing any one of three primary germ layer cell mass from pluripotent cells |
| EP3609997A4 (en) | 2017-04-14 | 2021-03-03 | Children's Hospital Medical Center | COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES |
| CA3066055A1 (en) | 2017-06-14 | 2018-12-20 | Semma Therapeutics, Inc. | Devices and methods for delivering therapeutics |
| US10391156B2 (en) | 2017-07-12 | 2019-08-27 | Viacyte, Inc. | University donor cells and related methods |
| EP3694603A4 (en) | 2017-10-10 | 2021-07-14 | Children's Hospital Medical Center | ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF |
| AU2018370029B2 (en) | 2017-11-15 | 2024-11-07 | Vertex Pharmaceuticals Incorporated | Islet cell manufacturing compositions and methods of use |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| KR102887406B1 (ko) | 2018-07-26 | 2025-11-19 | 칠드런즈 호스피탈 메디칼 센터 | 간-담도-췌장 조직 및 이를 제조하는 방법 |
| EP3833365A4 (en) | 2018-08-10 | 2022-05-11 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| US10724052B2 (en) | 2018-09-07 | 2020-07-28 | Crispr Therapeutics Ag | Universal donor cells |
| WO2020056158A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| US12435315B2 (en) | 2019-05-22 | 2025-10-07 | The Cleveland Clinic Foundation | Generating dorsal foregut, and anterior domain, endoderm cells |
| EP3976237A1 (en) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
| AU2020283056B2 (en) | 2019-05-31 | 2023-06-08 | Viacyte, Inc. | A biocompatible membrane composite |
| EP3975926A1 (en) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates, Inc. | A biocompatible membrane composite |
| CA3139591C (en) | 2019-05-31 | 2024-01-16 | Timothy M. BRUHN | A biocompatible membrane composite |
| US11118195B2 (en) | 2019-09-05 | 2021-09-14 | Crispr Therapeutics Ag | Universal donor cells |
| AU2020340622A1 (en) | 2019-09-05 | 2022-03-03 | Crispr Therapeutics Ag | Universal donor cells |
| US11850303B2 (en) | 2020-10-27 | 2023-12-26 | Uqora, Inc. | Gel and a suppository and methods to provide the gel and suppository |
| AU2021414405A1 (en) | 2020-12-31 | 2023-08-10 | Crispr Therapeutics Ag | Universal donor cells |
| WO2024151541A1 (en) | 2023-01-09 | 2024-07-18 | Sana Biotechnology, Inc. | Type-1 diabetes autoimmune mouse |
| WO2024243236A2 (en) | 2023-05-22 | 2024-11-28 | Sana Biotechnology, Inc. | Methods of delivery of islet cells and related methods |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2161804A (en) | 1935-11-09 | 1939-06-13 | Baldwin Southwark Corp | Hydraulic press |
| US4873702A (en) | 1988-10-20 | 1989-10-10 | Chiu Ran Fun | Method and apparatus for DC restoration in digital receivers |
| US6165993A (en) * | 1992-03-23 | 2000-12-26 | University Of Massachusetts Medical Center | DNA vaccines against rotavirus infections |
| US5690926A (en) * | 1992-10-08 | 1997-11-25 | Vanderbilt University | Pluripotential embryonic cells and methods of making same |
| US7153684B1 (en) * | 1992-10-08 | 2006-12-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| US5453357A (en) * | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US6015671A (en) * | 1995-06-07 | 2000-01-18 | Indiana University Foundation | Myocardial grafts and cellular compositions |
| US5874301A (en) * | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5843780A (en) * | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5748681A (en) | 1995-10-27 | 1998-05-05 | Lucent Technologies Inc | Offset correction for a homodyne radio |
| JP2001517927A (ja) | 1996-02-28 | 2001-10-09 | バンダービルト ユニバーシティ | 胚幹細胞を作製する組成物および方法 |
| US5877207A (en) * | 1996-03-11 | 1999-03-02 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| US5964261A (en) * | 1996-05-29 | 1999-10-12 | Baxter International Inc. | Implantation assembly |
| EP0986635A4 (en) | 1997-01-10 | 2001-11-07 | Life Technologies Inc | SERUM SUBSTITUTE FOR EMBRYONIC STEM CELLS |
| US5798644A (en) | 1997-02-20 | 1998-08-25 | At&T Corp | Method and apparatus for locating buried conveyances using locating & confirmation signals with an array of sensors |
| US5793230A (en) | 1997-02-26 | 1998-08-11 | Sandia Corporation | Sensor readout detector circuit |
| US6090622A (en) | 1997-03-31 | 2000-07-18 | The Johns Hopkins School Of Medicine | Human embryonic pluripotent germ cells |
| US6331406B1 (en) * | 1997-03-31 | 2001-12-18 | The John Hopkins University School Of Medicine | Human enbryonic germ cell and methods of use |
| US6261281B1 (en) * | 1997-04-03 | 2001-07-17 | Electrofect As | Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells |
| ES2279580T3 (es) | 1997-09-15 | 2007-08-16 | Genetic Immunity, Llc | Composiciones para administrar genes a celulas de la piel que presentan antigenos. |
| EP1025204A4 (en) | 1997-10-23 | 2001-02-28 | Geron Corp | Methods and materials for the growth of primate-derived primordial stem cells |
| US20030008919A1 (en) * | 1999-06-03 | 2003-01-09 | Jean-Baptiste Roullet | Use of retinoids to treat high blood pressure and other cardiovascular disease |
| US6921811B2 (en) * | 1998-09-22 | 2005-07-26 | Biosurface Engineering Technologies, Inc. | Bioactive coating composition and methods |
| US6667176B1 (en) * | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| DE19852800C1 (de) | 1998-11-16 | 2000-04-13 | Univ Albert Ludwigs Freiburg | Verfahren zur Herstellung von Antikörpern gegen ein Polypeptid, von dem die kodierende Nukleinsäure bekannt ist |
| EP1175487A2 (en) | 1999-02-10 | 2002-01-30 | Curis, Inc. | Pancreatic progenitor cells, methods and uses related thereto |
| US6872389B1 (en) * | 1999-07-08 | 2005-03-29 | Rhode Island Hospital | Liver stem cell |
| US7005252B1 (en) | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
| US6458589B1 (en) * | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
| US7256042B2 (en) * | 2000-04-27 | 2007-08-14 | Geron Corporation | Process for making hepatocytes from pluripotent stem cells |
| AU8617301A (en) | 2000-08-01 | 2002-02-13 | Yissum Res Dev Co | Directed differentiation of embryonic cells |
| WO2002034880A2 (en) | 2000-10-23 | 2002-05-02 | University Of Kansas | Cadherin peptides for drug delivery and inhibition of tumor metastasis/invasion |
| EP1366148A2 (en) | 2001-01-24 | 2003-12-03 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES | Differentiation of stem cells to pancreatic endocrine cells |
| WO2002101385A1 (en) * | 2001-06-13 | 2002-12-19 | Massachusetts Institute Of Technology | In vivo bioreactors |
| EP1298201A1 (en) | 2001-09-27 | 2003-04-02 | Cardion AG | Process for the production of cells exhibiting an islet-beta-cell-like state |
| US20050053588A1 (en) * | 2001-10-18 | 2005-03-10 | Li Yin | Conversion of liver stem and progenitor cells to pancreatic functional cells |
| WO2003046141A2 (en) | 2001-11-26 | 2003-06-05 | Advanced Cell Technology, Inc. | Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells |
| US7157278B2 (en) * | 2001-12-04 | 2007-01-02 | Organogenesis, Inc. | Cultured cells from pancreatic islets |
| GB2399823B (en) * | 2001-12-07 | 2006-02-15 | Geron Corp | Islet cells from primate pluripotent stem cells |
| US20030138949A1 (en) * | 2001-12-12 | 2003-07-24 | Anil Bhushan | Methods for the regeneration of pancreatic islets and expansion of pancreatic endocrine cells |
| WO2004098490A2 (en) * | 2002-05-17 | 2004-11-18 | Mount Sinai School Of Medicine Of New York University | Mesoderm and definitive endoderm cell populations |
| US20060003446A1 (en) * | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
| CN1668324A (zh) | 2002-05-28 | 2005-09-14 | 诺沃塞尔公司 | 用于胰岛素产生细胞的方法、组合物及生长与分化因子 |
| CN1662643A (zh) * | 2002-05-28 | 2005-08-31 | 贝克顿·迪金森公司 | 人腺泡细胞的扩增和转分化 |
| US20060040385A1 (en) * | 2002-12-05 | 2006-02-23 | Technion Research & Development Foundation Ltd. | Cultured human pancreatic islets, and uses thereof |
| FR2849043B1 (fr) * | 2002-12-24 | 2005-07-08 | Gemac | Procede de fabrication d'un vecteur de molecules actives applicable dans le domaine de la diffusion de principes actifs et vecteur obtenu |
| CA2515108A1 (en) * | 2003-02-07 | 2004-08-26 | Wisconsin Alumni Research Foundation | Directed genetic modifications of human stem cells |
| WO2005045001A2 (en) | 2003-02-14 | 2005-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Insulin-producing cells derived from stem cells |
| US20030224411A1 (en) * | 2003-03-13 | 2003-12-04 | Stanton Lawrence W. | Genes that are up- or down-regulated during differentiation of human embryonic stem cells |
| US20040229350A1 (en) | 2003-05-12 | 2004-11-18 | Nikolai Strelchenko | Morula derived embryonic stem cells |
| WO2004104184A1 (ja) | 2003-05-20 | 2004-12-02 | Riken | 内胚葉系幹細胞の調製 |
| WO2005017131A2 (en) | 2003-08-14 | 2005-02-24 | THE GOUVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT F HEALTH AND HUMAN SERVICES | Methods for the differentiation of human stem cells |
| WO2005033294A2 (en) | 2003-09-30 | 2005-04-14 | Regents Of The University Of California | Methods for maintaining hepatocytes in culture and for differentiating embryonic stem cells along a hepatocyte lineage |
| US20050266554A1 (en) * | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| US7625753B2 (en) * | 2003-12-23 | 2009-12-01 | Cythera, Inc. | Expansion of definitive endoderm cells |
| US7541185B2 (en) * | 2003-12-23 | 2009-06-02 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| WO2007059007A2 (en) * | 2005-11-14 | 2007-05-24 | Cythera, Inc. | Markers of definitive endoderm |
| KR101221302B1 (ko) * | 2003-12-23 | 2013-01-11 | 비아싸이트, 인크. | 완전 내배엽 |
| US7985585B2 (en) * | 2004-07-09 | 2011-07-26 | Viacyte, Inc. | Preprimitive streak and mesendoderm cells |
| WO2005086860A2 (en) * | 2004-03-09 | 2005-09-22 | Gang Xu | Methods for generating insulin-producing cells |
| WO2005097980A2 (en) | 2004-03-26 | 2005-10-20 | Geron Corporation | New protocols for making hepatocytes from embryonic stem cells |
| CA2555571C (en) * | 2004-04-01 | 2012-10-16 | Wisconsin Alumni Research Foundation | Differentiation of stem cells to endoderm and pancreatic lineage |
| EP2377922B1 (en) * | 2004-04-27 | 2020-04-08 | Viacyte, Inc. | PDX1 expressing endoderm |
| ES2751095T3 (es) * | 2004-04-27 | 2020-03-30 | Viacyte Inc | Endodermo que expresa pdx1 |
| ES2754038T3 (es) | 2004-07-09 | 2020-04-15 | Viacyte Inc | Células mesendodérmicas y células de línea pre-primitiva |
| AU2005272078B2 (en) * | 2004-07-09 | 2011-04-14 | Viacyte, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| EP1791952A4 (en) | 2004-08-13 | 2008-06-11 | Univ Georgia Res Found | COMPOSITIONS AND METHODS OF SELF-RENEWAL AND DIFFERENTIATION IN HUMAN EMBRYONAL STEM CELLS |
| WO2006034873A1 (en) | 2004-09-29 | 2006-04-06 | Cellartis Ab | METHODS FOR THE GENERATION OF HEPATOCYTE-LIKE CELLS FROM HUMAN BLASTOCYST-DERIVED STEM (hBs) |
| JP2008528038A (ja) | 2005-01-31 | 2008-07-31 | エス セル インターナショナル ピーティーイー リミテッド | 胚性幹細胞の指示された分化及びその利用 |
| CN100425694C (zh) | 2005-04-15 | 2008-10-15 | 北京大学 | 诱导胚胎干细胞向胰腺细胞分化的方法 |
| WO2007002210A2 (en) | 2005-06-20 | 2007-01-04 | Bresagen, Inc. | Embryonic stem cell culture compositions and methods of use thereof |
| US7732202B2 (en) * | 2005-10-21 | 2010-06-08 | International Stem Cell Corporation | Oxygen tension for the parthenogenic activation of human oocytes for the production of human embryonic stem cells |
| EP3584311A1 (en) | 2005-10-27 | 2019-12-25 | Viacyte, Inc. | Pdx-1 expressing dorsal and ventral foregut endoderm |
| GB0602063D0 (en) | 2006-02-02 | 2006-03-15 | Univ Manchester | Cell Culture |
| CA2644468C (en) | 2006-03-02 | 2022-02-01 | Cythera, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
| US7695965B2 (en) * | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
| AU2007277364B2 (en) * | 2006-07-26 | 2010-08-12 | Viacyte, Inc. | Methods of producing pancreatic hormones |
| US20080241250A1 (en) * | 2006-11-08 | 2008-10-02 | Emans Pieter J | In vivo bioreactors and methods of making and using same |
| US7695963B2 (en) * | 2007-09-24 | 2010-04-13 | Cythera, Inc. | Methods for increasing definitive endoderm production |
-
2006
- 2006-10-27 EP EP19179403.1A patent/EP3584311A1/en not_active Withdrawn
- 2006-10-27 EP EP06827129.5A patent/EP1957636B1/en active Active
- 2006-10-27 WO PCT/US2006/042413 patent/WO2007051038A2/en not_active Ceased
- 2006-10-27 CN CNA2006800497075A patent/CN101351547A/zh active Pending
- 2006-10-27 DK DK06827129.5T patent/DK1957636T3/en active
- 2006-10-27 JP JP2008538095A patent/JP5404047B2/ja active Active
- 2006-10-27 US US11/588,693 patent/US20070122905A1/en not_active Abandoned
- 2006-10-27 ES ES13171221T patent/ES2743202T3/es active Active
- 2006-10-27 EP EP13171221.8A patent/EP2674485B1/en active Active
- 2006-10-27 DK DK13171221.8T patent/DK2674485T3/da active
- 2006-10-27 AU AU2006305879A patent/AU2006305879B2/en active Active
- 2006-10-27 ES ES06827129.5T patent/ES2687233T3/es active Active
- 2006-10-27 PL PL06827129T patent/PL1957636T3/pl unknown
- 2006-10-27 CA CA2869687A patent/CA2869687C/en active Active
- 2006-10-27 CA CA2627645A patent/CA2627645C/en active Active
-
2010
- 2010-03-22 US US12/729,084 patent/US20100233755A1/en not_active Abandoned
-
2013
- 2013-07-05 JP JP2013141267A patent/JP5968270B2/ja active Active
- 2013-08-09 US US13/962,978 patent/US9499795B2/en active Active
-
2015
- 2015-04-28 JP JP2015091898A patent/JP6077046B2/ja active Active
-
2016
- 2016-10-11 US US15/290,850 patent/US20170022474A1/en not_active Abandoned
- 2016-11-28 JP JP2016229718A patent/JP6366115B2/ja active Active
-
2018
- 2018-05-21 JP JP2018097236A patent/JP6595041B2/ja active Active
- 2018-11-26 US US16/200,493 patent/US11427805B2/en active Active
-
2022
- 2022-07-25 US US17/814,791 patent/US20230040286A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009513143A5 (enExample) | ||
| JP2008503203A5 (enExample) | ||
| Weatherbee et al. | Modeling human embryo development with embryonic and extra-embryonic stem cells | |
| Wang et al. | Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm | |
| JP6450674B2 (ja) | ヒト胚性幹細胞の膵臓の内胚葉への分化 | |
| KR102468315B1 (ko) | 인간 배아 줄기 세포의 췌장 내분비 세포로의 분화 | |
| Toivonen et al. | Activin A and Wnt-dependent specification of human definitive endoderm cells | |
| CN105849252B (zh) | 培养多能干细胞 | |
| US8278105B2 (en) | Induction, propagation and isolation of liver progenitor cells | |
| CN116286663A (zh) | 人多能干细胞衍生的功能性β细胞的体外产生 | |
| EP2909312A1 (en) | Methods of differentiating stem cells into one or more cell lineages | |
| Mfopou et al. | Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: a rapid screening model for differentiation studies | |
| Grapin-Botton | Endoderm specification | |
| Weatherbee et al. | Transgene directed induction of a stem cell-derived human embryo model | |
| Liu et al. | Nodal mutant e X traembryonic EN doderm (XEN) stem cells upregulate markers for the anterior visceral endoderm and impact the timing of cardiac differentiation in mouse embryoid bodies | |
| Porciuncula et al. | MicroRNA signatures of iPSCs and endoderm-derived tissues | |
| Turovets et al. | Human parthenogenetic stem cells produce enriched populations of definitive endoderm cells after trichostatin A pretreatment | |
| JP2018148933A5 (enExample) | ||
| Rahkonen | Regulation of self-renewal and detection of karyotypic changes of pluripotent human embryonic stem cells | |
| Khong | Directed Differentiation of Human Embryonic Stem Cells to Insulin Producing Cells by Regulating GATA Genes Cascade | |
| Wang | Aryl Hydrocarbon Receptor-Mediated Regulation of Gene Expression during Cardiomyocyte Differentiation | |
| Nair | Establishing a PTF1a-initiated in vitro model of pancreas development in embryonic stem cells and its application to uncover mechanisms of pancreatic progenitor fate determination | |
| HK1209160B (en) | Differentiation of human embryonic stem cells into pancreatic endocrine cells |