JP2008503203A5 - - Google Patents

Download PDF

Info

Publication number
JP2008503203A5
JP2008503203A5 JP2007510879A JP2007510879A JP2008503203A5 JP 2008503203 A5 JP2008503203 A5 JP 2008503203A5 JP 2007510879 A JP2007510879 A JP 2007510879A JP 2007510879 A JP2007510879 A JP 2007510879A JP 2008503203 A5 JP2008503203 A5 JP 2008503203A5
Authority
JP
Japan
Prior art keywords
pdx1
growth factor
cell culture
retinoid
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007510879A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008503203A (ja
JP4926946B2 (ja
Filing date
Publication date
Priority claimed from US11/021,618 external-priority patent/US7510876B2/en
Application filed filed Critical
Priority claimed from PCT/US2005/014239 external-priority patent/WO2005116073A2/en
Publication of JP2008503203A publication Critical patent/JP2008503203A/ja
Publication of JP2008503203A5 publication Critical patent/JP2008503203A5/ja
Application granted granted Critical
Publication of JP4926946B2 publication Critical patent/JP4926946B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2007510879A 2004-04-27 2005-04-26 Pdx1発現性内胚葉 Expired - Lifetime JP4926946B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US56629304P 2004-04-27 2004-04-27
US60/566,293 2004-04-27
US58656604P 2004-07-09 2004-07-09
US60/586,566 2004-07-09
US58794204P 2004-07-14 2004-07-14
US60/587,942 2004-07-14
US11/021,618 2004-12-23
US11/021,618 US7510876B2 (en) 2003-12-23 2004-12-23 Definitive endoderm
PCT/US2005/014239 WO2005116073A2 (en) 2004-04-27 2005-04-26 Pdx1 expressing endoderm

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011147598A Division JP5669681B2 (ja) 2004-04-27 2011-07-01 Pdx1発現性内胚葉

Publications (3)

Publication Number Publication Date
JP2008503203A JP2008503203A (ja) 2008-02-07
JP2008503203A5 true JP2008503203A5 (enExample) 2008-06-19
JP4926946B2 JP4926946B2 (ja) 2012-05-09

Family

ID=45319532

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2007510879A Expired - Lifetime JP4926946B2 (ja) 2004-04-27 2005-04-26 Pdx1発現性内胚葉
JP2011147598A Expired - Lifetime JP5669681B2 (ja) 2004-04-27 2011-07-01 Pdx1発現性内胚葉
JP2014168939A Expired - Lifetime JP6158152B2 (ja) 2004-04-27 2014-08-22 Pdx1発現性内胚葉
JP2015111656A Expired - Lifetime JP6265942B2 (ja) 2004-04-27 2015-06-01 Pdx1発現性内胚葉
JP2017026645A Expired - Lifetime JP6605520B2 (ja) 2004-04-27 2017-02-16 Pdx1発現性内胚葉
JP2018167312A Expired - Lifetime JP6709262B2 (ja) 2004-04-27 2018-09-06 Pdx1発現性内胚葉

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2011147598A Expired - Lifetime JP5669681B2 (ja) 2004-04-27 2011-07-01 Pdx1発現性内胚葉
JP2014168939A Expired - Lifetime JP6158152B2 (ja) 2004-04-27 2014-08-22 Pdx1発現性内胚葉
JP2015111656A Expired - Lifetime JP6265942B2 (ja) 2004-04-27 2015-06-01 Pdx1発現性内胚葉
JP2017026645A Expired - Lifetime JP6605520B2 (ja) 2004-04-27 2017-02-16 Pdx1発現性内胚葉
JP2018167312A Expired - Lifetime JP6709262B2 (ja) 2004-04-27 2018-09-06 Pdx1発現性内胚葉

Country Status (14)

Country Link
EP (1) EP1740612B1 (enExample)
JP (6) JP4926946B2 (enExample)
KR (2) KR101278421B1 (enExample)
CN (1) CN103103158B (enExample)
AU (1) AU2005247869B2 (enExample)
CA (1) CA2564114C (enExample)
DK (2) DK2377922T3 (enExample)
EA (1) EA011953B1 (enExample)
ES (2) ES2801001T3 (enExample)
IL (1) IL178847A (enExample)
MX (1) MXPA06012445A (enExample)
NZ (1) NZ550605A (enExample)
SG (1) SG152273A1 (enExample)
WO (1) WO2005116073A2 (enExample)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8586357B2 (en) 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
JP4819697B2 (ja) 2003-12-23 2011-11-24 ヴィアサイト,インコーポレイテッド 胚体内胚葉
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
EP1786896B1 (en) * 2004-07-09 2018-01-10 Viacyte, Inc. Methods for identifying factors for differentiating definitive endoderm
JP5102030B2 (ja) 2004-08-13 2012-12-19 ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド ヒト胚性幹細胞における自己再生および分化のための組成物および方法
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
EP1838843B1 (en) * 2004-12-23 2019-07-10 Viacyte, Inc. Expansion of definitive endoderm cells
CA2613812A1 (en) * 2005-01-31 2006-08-10 Es Cell International Pte Ltd. Directed differentiation of embryonic stem cells and uses thereof
AU2006252402B2 (en) * 2005-06-02 2010-11-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Prevascularized devices and related methods
EP1888123B1 (en) 2005-06-08 2013-01-09 Janssen Biotech, Inc. A cellular therapy for ocular degeneration
EP3584311A1 (en) * 2005-10-27 2019-12-25 Viacyte, Inc. Pdx-1 expressing dorsal and ventral foregut endoderm
AU2012202481B2 (en) * 2005-10-27 2015-07-02 Viacyte, Inc. PDX1-expressing dorsal and ventral foregut endoderm
SG10201405107YA (en) 2006-02-23 2014-10-30 Viacyte Inc Compositions and methods useful for culturing differentiable cells
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
DK2650359T3 (da) * 2006-03-02 2022-06-13 Viacyte Inc Endokrine prekursorceller, pancreatiske hormon-udtrykkende celler og fremstillingsfremgangsmåder
US11254916B2 (en) 2006-03-02 2022-02-22 Viacyte, Inc. Methods of making and using PDX1-positive pancreatic endoderm cells
WO2007127927A2 (en) * 2006-04-28 2007-11-08 Lifescan, Inc. Differentiation of human embryonic stem cells
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
WO2007127454A2 (en) * 2006-04-28 2007-11-08 Cythera, Inc. Hepatocyte lineage cells
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
US9096832B2 (en) 2007-07-31 2015-08-04 Lifescan, Inc. Differentiation of human embryonic stem cells
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
ATE523585T1 (de) 2007-11-27 2011-09-15 Lifescan Inc Differenzierung menschlicher embryonaler stammzellen
WO2009083502A1 (en) 2007-12-28 2009-07-09 Novo Nordisk A/S Ddr1-mediated cell purification of pancreatic endocrine cells through their progenitors
CA2959401C (en) 2008-02-21 2021-12-07 Centocor Ortho Biotech Inc. Methods, surface modified plates and compositions for cell attachment, cultivation and detachment
EP2263083A1 (en) 2008-04-03 2010-12-22 Novo Nordisk A/S Dner-mediated cell purification of pancreatic endocrine pre-progenitor cells and their progeny
US7939322B2 (en) 2008-04-24 2011-05-10 Centocor Ortho Biotech Inc. Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
KR101651661B1 (ko) 2008-06-30 2016-08-26 얀센 바이오테크 인코포레이티드 만능 줄기 세포의 분화
EP2318516A1 (en) * 2008-06-30 2011-05-11 Centocor Ortho Biotech Inc. Differentiation of pluripotent stem cells
CN102272291B (zh) 2008-10-31 2018-01-16 詹森生物科技公司 人胚胎干细胞向胰腺内分泌谱系的分化
MX2011004563A (es) 2008-10-31 2011-06-01 Centocor Ortho Biotech Inc Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico.
US8895300B2 (en) 2008-11-04 2014-11-25 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
JP2012508584A (ja) 2008-11-14 2012-04-12 ヴィアサイト,インコーポレイテッド ヒト多能性幹細胞由来膵臓細胞のカプセル化
PL2366022T3 (pl) 2008-11-20 2016-11-30 Sposoby i kompozycje do przyłączania i hodowli komórek na podłożach planarnych
PL2366021T3 (pl) 2008-11-20 2017-12-29 Janssen Biotech, Inc. Hodowla pluripotencjalnych komórek macierzystych na mikronośnikach
ES2693088T3 (es) 2009-07-20 2018-12-07 Janssen Biotech, Inc. Diferenciación de células madre embriónicas humanas
AU2010276402B2 (en) 2009-07-20 2014-07-03 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
KR20170118969A (ko) 2009-07-20 2017-10-25 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
AU2010333839C1 (en) 2009-12-23 2016-07-21 Janssen Biotech Inc. Differentiation of human embryonic stem cells
US12441985B2 (en) 2009-12-23 2025-10-14 Janssen Biotech, Inc. Methods for making insulin in vivo
MX339669B (es) 2009-12-23 2016-06-02 Janssen Biotech Inc Diferenciacion de celulas madres embrionarias humanas.
CN107189979B (zh) 2010-03-01 2021-05-04 詹森生物科技公司 纯化衍生自多能干细胞的细胞的方法
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
KR101986176B1 (ko) 2010-05-12 2019-06-05 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
WO2012030539A2 (en) 2010-08-31 2012-03-08 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
WO2012030540A2 (en) 2010-08-31 2012-03-08 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
AU2011296381B2 (en) 2010-08-31 2016-03-31 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
JP5888852B2 (ja) * 2010-12-08 2016-03-22 学校法人近畿大学 免疫不全動物を用いた細胞の製法
JP2012143229A (ja) * 2010-12-24 2012-08-02 Chiba Univ 多能性幹細胞培養用組成物およびその用途
JP6312591B2 (ja) 2011-06-21 2018-04-18 ノヴォ ノルディスク アー/エス 多能性幹細胞からの胚体内胚葉の効率的な誘導
US9388386B2 (en) 2011-12-22 2016-07-12 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into single hormonal insulin positive cells
CA2866590A1 (en) 2012-03-07 2013-09-12 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
WO2013184888A1 (en) 2012-06-08 2013-12-12 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endocrine cells
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
WO2014105543A1 (en) 2012-12-31 2014-07-03 Janssen Biotech, Inc. Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells
RU2687379C2 (ru) 2012-12-31 2019-05-13 Янссен Байотек, Инк. Суспендирование и кластеризация плюрипотентных клеток человека с целью их дифференцировки в панкреатические эндокринные клетки
RU2684215C2 (ru) 2012-12-31 2019-04-04 Янссен Байотек, Инк. Способ получения панкреатических эндокринных клеток (варианты) и способ увеличения выхода бета-клеток
JP6588969B2 (ja) 2014-05-16 2019-10-09 ヤンセン バイオテツク,インコーポレーテツド 膵内分泌細胞内のmafa発現を強化するための小分子の使用
EP3712254A1 (en) 2014-05-28 2020-09-23 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
CA2963704A1 (en) 2014-10-17 2016-04-21 Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
PT3286300T (pt) 2015-04-24 2020-12-28 Univ Copenhagen Isolamento de células progenitoras pancreáticas genuínas
JP6705911B2 (ja) 2016-04-14 2020-06-03 ヤンセン バイオテツク,インコーポレーテツド 多能性幹細胞の中腸内胚葉細胞への分化
EP4177335A1 (en) 2016-05-05 2023-05-10 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
SG11201903697WA (en) 2016-11-04 2019-05-30 Childrens Hospital Med Ct Liver organoid compositions and methods of making and using same
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
EP3609997A4 (en) 2017-04-14 2021-03-03 Children's Hospital Medical Center COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES
US12297457B2 (en) 2017-10-10 2025-05-13 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
CA2983845C (en) 2017-10-26 2024-01-30 University Of Copenhagen Generation of glucose-responsive beta cells
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
US12421500B2 (en) 2018-07-26 2025-09-23 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
JP2021535753A (ja) 2018-09-12 2021-12-23 チルドレンズ ホスピタル メディカル センター 造血幹細胞およびその派生体の生成のためのオルガノイド組成物
WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
WO2020243666A1 (en) 2019-05-31 2020-12-03 W. L. Gore & Associates, Inc. A biocompatible membrane composite
JP7555975B2 (ja) 2019-05-31 2024-09-25 ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド 生体適合性メンブレン複合体
JP2022534545A (ja) 2019-05-31 2022-08-01 ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド 生体適合性メンブレン複合体
CA3141814A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
CA3257300A1 (en) 2019-05-31 2025-06-12 W. L. Gore & Associates, Inc. Cell encapsulation devices with controlled oxygen diffusion distances
CN114174494A (zh) 2019-05-31 2022-03-11 儿童医院医学中心 产生和扩增造血干细胞的方法
KR20230051519A (ko) 2020-08-15 2023-04-18 리제너론 파마슈티칼스 인코포레이티드 칼시토닌 수용체 (calcr)를 인코딩하는 변이체 핵산 분자를 갖는 대상체에서 비만의 치료

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3945846B2 (ja) * 1995-11-09 2007-07-18 武田薬品工業株式会社 膵臓機能改善剤
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
CA2362593A1 (en) * 1999-02-10 2000-08-17 Curis, Inc. Pancreatic progenitor cells, methods and uses related thereto
JP4426064B2 (ja) * 2000-05-31 2010-03-03 独立行政法人科学技術振興機構 脊椎動物の膵臓のインビトロ形成方法
AU2001273108A1 (en) * 2000-06-30 2002-01-14 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
JP2004504834A (ja) * 2000-08-01 2004-02-19 イスム リサーチ ディベロップメント カンパニー 胚性細胞の定方向分化
WO2002102997A2 (en) * 2000-11-30 2002-12-27 Stemron Inc. Isolated homozygous stem cells differentiated cells derived therefrom and materials and methods for making and using same
CA2435826A1 (en) * 2001-01-24 2002-08-01 The Government Of The United States Of America Differentiation of stem cells to pancreatic endocrine cells
JP2004531262A (ja) * 2001-05-15 2004-10-14 ラッパポート ファミリー インスチチュート フォア リサーチ イン ザ メディカル サイエンシズ ヒト胚性幹細胞由来インスリン産生細胞
WO2002096203A1 (en) * 2001-05-25 2002-12-05 Cythera, Inc. Stem cell differentiation
AU2002312514A1 (en) * 2001-06-14 2003-01-02 Regents Of The University Of California Hoxd3 compositions ad methods for improved wound healing
EP1298201A1 (en) * 2001-09-27 2003-04-02 Cardion AG Process for the production of cells exhibiting an islet-beta-cell-like state
MXPA04005010A (es) * 2001-11-26 2005-04-08 Advanced Cell Tech Inc METODO PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS METODOS PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS HUMANOS REPROGRAMADOS Y CELULAS DEL TALLO HUMANAS AUTOLOGAS E ISOGENICAS.
CN101240262A (zh) * 2001-12-07 2008-08-13 杰龙公司 源自人胚胎干细胞的胰岛细胞
US20030138949A1 (en) * 2001-12-12 2003-07-24 Anil Bhushan Methods for the regeneration of pancreatic islets and expansion of pancreatic endocrine cells
US20030162290A1 (en) * 2002-01-25 2003-08-28 Kazutomo Inoue Method for inducing differentiation of embryonic stem cells into functioning cells
AU2003239159A1 (en) * 2002-04-19 2003-11-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education Placental derived stem cells and uses thereof
EP1516925A1 (en) * 2003-09-18 2005-03-23 Fundacion IVI para el Estudio de la reproduccion Humana (FIVIER) Generation of human embryonic stem cells from triploid zygotes
JP4491014B2 (ja) * 2004-04-01 2010-06-30 ウイスコンシン アラムニ リサーチ ファンデーション 幹細胞の内胚葉および膵臓系統への分化

Similar Documents

Publication Publication Date Title
JP2009513143A5 (enExample)
Io et al. Capturing human trophoblast development with naive pluripotent stem cells in vitro
JP2020103321A (ja) 前原始線条及び中内胚葉細胞
Golan-Mashiach et al. Design principle of gene expression used by human stem cells; implication for pluripotency
CA2549605A1 (en) Definitive endoderm
KR20190018709A (ko) 혈액을 유도 만능 줄기세포로 리프로그래밍하기 위한 신규하고 효율적인 방법
Pera et al. Gene expression profiles of human inner cell mass cells and embryonic stem cells
Pal et al. Comparative analysis of cardiomyocyte differentiation from human embryonic stem cells under 3-D and 2-D culture conditions
JP2012532585A5 (enExample)
EP3121276A1 (en) Cardiomyocyte sorting method
Xie et al. Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts
Zhi et al. Elucidation of the pluripotent potential of bovine embryonic lineages facilitates the establishment of formative stem cell lines
Sudheer et al. Different concentrations of FGF ligands, FGF2 or FGF8 determine distinct states of WNT-induced presomitic mesoderm
EP3571291A1 (en) Maintenance and expansion of pancreatic progenitor cells
Zhong et al. Barhl1 is required for the differentiation of inner ear hair cell-like cells from mouse embryonic stem cells
Liu et al. Human blastoid as an in vitro model of human blastocysts
Ding et al. ETV2 overexpression promotes efficient differentiation of pluripotent stem cells to endothelial cells
Wang et al. Wnt inhibition safeguards porcine embryonic stem cells from the acquisition of extraembryonic endoderm cell fates
WO2018037091A1 (en) Methods for the identification and isolation of hematopoietic stem and progenitor cells
Nelson et al. Lineage specification of Flk-1+ progenitors is associated with divergent Sox7 expression in cardiopoiesis
Han et al. Isolation and in vitro culture of pig spermatogonial stem cell
Tobias et al. Targeted expression profiling reveals distinct stages of early canine fibroblast reprogramming are regulated by 2-oxoglutarate hydroxylases
CN119432720B (zh) 猪胚胎干细胞诱导形成猪类囊胚的方法及培养基
Rungarunlert et al. Enhanced cardiac differentiation of mouse embryonic stem cells by use of the slow-turning, lateral vessel (STLV) bioreactor
WO2022039279A1 (ja) ヒト始原生殖細胞/ヒト始原生殖細胞様細胞の維持増幅方法