JP2012532585A5 - - Google Patents
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- Publication number
- JP2012532585A5 JP2012532585A5 JP2011554336A JP2011554336A JP2012532585A5 JP 2012532585 A5 JP2012532585 A5 JP 2012532585A5 JP 2011554336 A JP2011554336 A JP 2011554336A JP 2011554336 A JP2011554336 A JP 2011554336A JP 2012532585 A5 JP2012532585 A5 JP 2012532585A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- positive
- pluripotent stem
- cell
- igf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 20
- 238000000034 method Methods 0.000 claims 18
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 9
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 8
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 8
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims 8
- 102000001393 Platelet-Derived Growth Factor alpha Receptor Human genes 0.000 claims 7
- 108010068588 Platelet-Derived Growth Factor alpha Receptor Proteins 0.000 claims 7
- 238000012258 culturing Methods 0.000 claims 6
- 210000002027 skeletal muscle Anatomy 0.000 claims 6
- 210000000130 stem cell Anatomy 0.000 claims 6
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 4
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims 4
- 108050003627 Wnt Proteins 0.000 claims 4
- 102000013814 Wnt Human genes 0.000 claims 4
- 239000000411 inducer Substances 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 2
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims 2
- 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 claims 2
- 101000899361 Homo sapiens Bone morphogenetic protein 7 Proteins 0.000 claims 2
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 2
- 101710099061 Myogenic factor 5 Proteins 0.000 claims 2
- 102100038380 Myogenic factor 5 Human genes 0.000 claims 2
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 2
- 101150086694 SLC22A3 gene Proteins 0.000 claims 2
- 101001023030 Toxoplasma gondii Myosin-D Proteins 0.000 claims 2
- 102000052547 Wnt-1 Human genes 0.000 claims 2
- 108700020987 Wnt-1 Proteins 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000008672 reprogramming Effects 0.000 claims 2
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims 1
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims 1
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims 1
- 210000001811 primitive streak Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27047909P | 2009-07-09 | 2009-07-09 | |
| US61/270,479 | 2009-07-09 | ||
| PCT/JP2010/062023 WO2011004911A1 (en) | 2009-07-09 | 2010-07-09 | Method of inducing differentiation from pluripotent stem cells to skeletal muscle progenitor cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012532585A JP2012532585A (ja) | 2012-12-20 |
| JP2012532585A5 true JP2012532585A5 (enExample) | 2013-08-15 |
| JP5846558B2 JP5846558B2 (ja) | 2016-01-20 |
Family
ID=43429331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011554336A Active JP5846558B2 (ja) | 2009-07-09 | 2010-07-09 | 多能性幹細胞から骨格筋前駆細胞への分化誘導方法 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20120164731A1 (enExample) |
| JP (1) | JP5846558B2 (enExample) |
| WO (1) | WO2011004911A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2315829B1 (en) | 2008-08-08 | 2015-02-11 | Mayo Foundation For Medical Education And Research | Induced pluripotent stem cells |
| CA2760042C (en) | 2009-04-27 | 2020-03-10 | Ottawa Hospital Research Institute | Compositions and methods for modulating stem cells and uses thereof |
| KR101334404B1 (ko) * | 2011-04-28 | 2013-12-12 | 포항공과대학교 산학협력단 | 배아줄기세포 유래의 인공 마이크로베시클을 이용한 역분화 유도만능줄기세포의 제조방법 |
| US20130029416A1 (en) | 2011-07-22 | 2013-01-31 | Tayaramma Thatava | Differentiating induced pluripotent stem cells into glucose-responsive, insulin-secreting progeny |
| JP6570833B2 (ja) * | 2011-08-29 | 2019-09-04 | アンスティトゥー ナショナル ドゥ ラ サンテ エ ドゥ ラ レシェルシュ メディカル（イエヌエスエエールエム） | 人工沿軸中胚葉前駆（ｉＰＡＭ）細胞を調製する方法及びその使用 |
| JP5785619B2 (ja) | 2011-09-15 | 2015-09-30 | 生化学工業株式会社 | 骨格筋再生促進剤 |
| WO2015064585A1 (ja) * | 2013-10-29 | 2015-05-07 | 国立大学法人熊本大学 | 筋疾患の治療または予防のための医薬組成物 |
| US20170009210A1 (en) * | 2014-02-05 | 2017-01-12 | Mayo Foundation For Medical Education And Research | Guided differentiation of induced pluripotent stem cells |
| US20170327791A1 (en) * | 2014-11-14 | 2017-11-16 | Jcr Pharmaceuticals Co., Ltd | Muscular dystrophy therapeutic agent containing pluripotent stem cells derived from dental pulp |
| KR101636533B1 (ko) * | 2014-12-22 | 2016-07-05 | 경북대학교 산학협력단 | 체세포로부터 근육줄기세포로의 역분화 유도용 조성물 및 이를 이용한 근육줄기세포의 제조방법 |
| JP6845500B2 (ja) * | 2014-12-29 | 2021-03-17 | 国立大学法人京都大学 | 骨格筋前駆細胞の製造方法 |
| WO2016141084A1 (en) * | 2015-03-03 | 2016-09-09 | The Board Of Trustees Of The Leland Stanford Junior University | Producing mesodermal cell types and methods of using the same |
| JP2017108705A (ja) * | 2015-12-18 | 2017-06-22 | 国立大学法人京都大学 | 心筋細胞の製造方法 |
| CA3044691A1 (en) | 2016-10-26 | 2018-05-03 | Genea Biocells USA (Holdings), Inc. | Improved generation of muscle lineage cells and therapeutic uses thereof |
| CN111225974B (zh) * | 2017-10-25 | 2021-09-17 | 雪拉托兹治疗株式会社 | 新型肌肉骨骼系统干细胞 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2626152A1 (en) * | 2005-10-24 | 2007-05-03 | Agency For Science, Technology And Research | Methods of specifying mesodermal, endodermal and mesoendodermal cell fates |
| AU2008211103B2 (en) * | 2007-01-30 | 2014-05-08 | University Of Georgia Research Foundation, Inc. | Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (MMC) |
| US9057051B2 (en) * | 2008-10-31 | 2015-06-16 | Katholieke Universiteit Leuven | Optimized methods for differentiation of cells into cells with hepatocyte progenitor phenotypes, cells produced by the methods, and methods of using the cells |
-
2010
- 2010-07-09 JP JP2011554336A patent/JP5846558B2/ja active Active
- 2010-07-09 WO PCT/JP2010/062023 patent/WO2011004911A1/en not_active Ceased
- 2010-07-09 US US13/382,470 patent/US20120164731A1/en not_active Abandoned
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