JP2012050357A5 - - Google Patents
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- Publication number
- JP2012050357A5 JP2012050357A5 JP2010193828A JP2010193828A JP2012050357A5 JP 2012050357 A5 JP2012050357 A5 JP 2012050357A5 JP 2010193828 A JP2010193828 A JP 2010193828A JP 2010193828 A JP2010193828 A JP 2010193828A JP 2012050357 A5 JP2012050357 A5 JP 2012050357A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- stem cells
- hematopoietic
- vitro
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 30
- 238000000338 in vitro Methods 0.000 claims 15
- 230000003321 amplification Effects 0.000 claims 10
- 238000003199 nucleic acid amplification method Methods 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 101710176387 Transcription factor SOX-17 Proteins 0.000 claims 7
- 102100030243 Transcription factor SOX-17 Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 238000012258 culturing Methods 0.000 claims 5
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 4
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 4
- 101000608935 Homo sapiens Leukosialin Proteins 0.000 claims 4
- 102100039564 Leukosialin Human genes 0.000 claims 4
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 4
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 102000046148 human BMP4 Human genes 0.000 claims 3
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 102000058223 human VEGFA Human genes 0.000 claims 2
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 2
- 102000008137 Bone Morphogenetic Protein 4 Human genes 0.000 claims 1
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 1
- 101000980898 Homo sapiens Cell division cycle-associated protein 4 Proteins 0.000 claims 1
- 101000716729 Homo sapiens Kit ligand Proteins 0.000 claims 1
- 101000799461 Homo sapiens Thrombopoietin Proteins 0.000 claims 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 229940126864 fibroblast growth factor Drugs 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 102000044493 human CDCA4 Human genes 0.000 claims 1
- 102000055151 human KITLG Human genes 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010193828A JP5794510B2 (ja) | 2010-08-31 | 2010-08-31 | 造血幹細胞の効率的な誘導および増幅方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010193828A JP5794510B2 (ja) | 2010-08-31 | 2010-08-31 | 造血幹細胞の効率的な誘導および増幅方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012050357A JP2012050357A (ja) | 2012-03-15 |
| JP2012050357A5 true JP2012050357A5 (enExample) | 2013-10-17 |
| JP5794510B2 JP5794510B2 (ja) | 2015-10-14 |
Family
ID=45904523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010193828A Active JP5794510B2 (ja) | 2010-08-31 | 2010-08-31 | 造血幹細胞の効率的な誘導および増幅方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5794510B2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014236285A1 (en) * | 2013-03-14 | 2015-11-05 | Children's Medical Center Corporation | Compositions and methods for reprogramming hematopoietic stem cell lineages |
| CA3007299A1 (en) | 2015-12-03 | 2017-06-08 | The Brigham And Women's Hospital, Inc. | Methods for generating functional hematopoietic stem cells |
| CN110904041A (zh) * | 2019-12-05 | 2020-03-24 | 中山大学 | 一种促进造血干细胞扩增的药物及其用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8772028B2 (en) * | 2008-11-07 | 2014-07-08 | Sunnybrook Health Sciences Centre | CD34+CD7+CD5+CD1a-human progenitor T-cells produced in vitro and methods of using |
-
2010
- 2010-08-31 JP JP2010193828A patent/JP5794510B2/ja active Active
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