JP2011517563A5 - - Google Patents
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- Publication number
- JP2011517563A5 JP2011517563A5 JP2011502014A JP2011502014A JP2011517563A5 JP 2011517563 A5 JP2011517563 A5 JP 2011517563A5 JP 2011502014 A JP2011502014 A JP 2011502014A JP 2011502014 A JP2011502014 A JP 2011502014A JP 2011517563 A5 JP2011517563 A5 JP 2011517563A5
- Authority
- JP
- Japan
- Prior art keywords
- progenitor cells
- human
- cardiovascular progenitor
- population
- human cardiovascular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 35
- 210000000130 stem cell Anatomy 0.000 claims 24
- 230000002526 effect on cardiovascular system Effects 0.000 claims 23
- 102000013814 Wnt Human genes 0.000 claims 9
- 108050003627 Wnt Proteins 0.000 claims 9
- 238000012258 culturing Methods 0.000 claims 9
- 239000003112 inhibitor Substances 0.000 claims 9
- 102100030074 Dickkopf-related protein 1 Human genes 0.000 claims 8
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 8
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 8
- 101000864646 Homo sapiens Dickkopf-related protein 1 Proteins 0.000 claims 7
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 6
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 6
- 210000004413 cardiac myocyte Anatomy 0.000 claims 6
- 239000012679 serum free medium Substances 0.000 claims 6
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 5
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims 5
- 108010023082 activin A Proteins 0.000 claims 5
- 108010059616 Activins Proteins 0.000 claims 4
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 4
- 239000000488 activin Substances 0.000 claims 4
- 210000002242 embryoid body Anatomy 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 210000004509 vascular smooth muscle cell Anatomy 0.000 claims 2
- 101710099518 Dickkopf-related protein 1 Proteins 0.000 claims 1
- 102100030091 Dickkopf-related protein 2 Human genes 0.000 claims 1
- 101000864647 Homo sapiens Dickkopf-related protein 2 Proteins 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4004908P | 2008-03-27 | 2008-03-27 | |
| US61/040,049 | 2008-03-27 | ||
| PCT/US2009/038220 WO2009120762A2 (en) | 2008-03-27 | 2009-03-25 | Human cardiovascular progenitor cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011517563A JP2011517563A (ja) | 2011-06-16 |
| JP2011517563A5 true JP2011517563A5 (enExample) | 2012-05-24 |
| JP5801187B2 JP5801187B2 (ja) | 2015-10-28 |
Family
ID=41114664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011502014A Active JP5801187B2 (ja) | 2008-03-27 | 2009-03-25 | ヒト心血管前駆細胞 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10077428B2 (enExample) |
| EP (1) | EP2273996B8 (enExample) |
| JP (1) | JP5801187B2 (enExample) |
| AU (1) | AU2009228354B2 (enExample) |
| CA (1) | CA2717962C (enExample) |
| DK (1) | DK2273996T3 (enExample) |
| IL (2) | IL208334A (enExample) |
| WO (1) | WO2009120762A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008094597A2 (en) * | 2007-01-30 | 2008-08-07 | University Of Georgia Research Foundation, Inc. | Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc) |
| EP2490701B9 (en) | 2009-10-19 | 2017-11-15 | Cellular Dynamics International, Inc. | Cardiomyocyte production |
| CA2785677C (en) * | 2009-12-29 | 2019-06-25 | Cornell University | Methods for developing endothelial cells from pluripotent cells and endothelial cells derived therefrom |
| WO2011091945A1 (en) * | 2010-01-26 | 2011-08-04 | Université Libre de Bruxelles | Tools for isolating and following cardiovascular progenitor cells |
| CN104774804B (zh) | 2010-06-13 | 2018-10-26 | 中国科学院生物物理研究所 | 由干细胞制备心肌细胞的方法和组合物及其用途 |
| US9181529B2 (en) | 2010-10-19 | 2015-11-10 | Cellular Dynamics International, Inc. | Titration of differentiation medium components |
| US20140045265A1 (en) * | 2011-02-16 | 2014-02-13 | Salk Institute For Biological Studies | Robust and efficient differentiation of human pluripotent stem cells to multipotent vascular progenitors |
| WO2012135621A2 (en) | 2011-03-30 | 2012-10-04 | Cellular Dynamics International. Inc | Priming of pluripotent stem cells for neural differentiation |
| GB201109882D0 (en) | 2011-06-13 | 2011-07-27 | Cambridge Entpr Ltd | Population of smooth muscle cells of specific embryonic lineages |
| GB201121101D0 (en) * | 2011-12-08 | 2012-01-18 | Nhs Blood & Transplant | A method of preparing isolated cells and uses |
| JP5920741B2 (ja) * | 2012-03-15 | 2016-05-18 | ｉＨｅａｒｔ Ｊａｐａｎ株式会社 | 人工多能性幹細胞から心筋および血管系混合細胞群を製造する方法 |
| CN104508121B (zh) * | 2012-07-23 | 2018-01-19 | 中国科学院生物物理研究所 | 体外诱导多能干细胞分化为心室肌细胞的方法 |
| WO2014192925A1 (ja) * | 2013-05-31 | 2014-12-04 | ｉＨｅａｒｔ Ｊａｐａｎ株式会社 | 効率的な内皮細胞の誘導方法 |
| CN113648323A (zh) | 2013-06-05 | 2021-11-16 | 再生疗法有限公司 | 用于哺乳动物物种中诱导性组织再生的组合物和方法 |
| NZ716860A (en) * | 2013-09-13 | 2022-07-01 | Univ Health Network | Methods and compositions for generating epicardium cells |
| US11078462B2 (en) | 2014-02-18 | 2021-08-03 | ReCyte Therapeutics, Inc. | Perivascular stromal cells from primate pluripotent stem cells |
| US10240127B2 (en) | 2014-07-03 | 2019-03-26 | ReCyte Therapeutics, Inc. | Exosomes from clonal progenitor cells |
| GB201412554D0 (en) * | 2014-07-15 | 2014-08-27 | Cambridge Entpr Ltd | In vitro mesodermal differentiation |
| EP3259348A4 (en) | 2015-02-17 | 2018-07-18 | University Health Network | Methods for making and using sinoatrial node-like pacemaker cardiomyocytes and ventricular-like cardiomyocytes |
| EP3387112A4 (en) | 2015-12-07 | 2019-08-21 | BioTime, Inc. | METHOD FOR RECONNECTING BROWN FAT CELLS DERIVED FROM VARIOUS PLURIPOTENT STEM CELLS |
| US10612002B2 (en) | 2016-02-19 | 2020-04-07 | University Of Washington | Human pluripotent stem cell derived endocardial endothelium |
| WO2017147381A1 (en) * | 2016-02-25 | 2017-08-31 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Generation of expandable cardiovascular progenitor cells |
| JP2023524572A (ja) * | 2020-05-08 | 2023-06-12 | ユニバーシティー ヘルス ネットワーク | 心内膜細胞を作製および使用するための方法および組成物 |
| IL316055A (en) | 2022-04-15 | 2024-11-01 | Aspen Neuroscience Inc | Methods of classifying the differentiation state of cells and related compositions of differentiated cells |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5874301A (en) | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5919449A (en) * | 1995-05-30 | 1999-07-06 | Diacrin, Inc. | Porcine cardiomyocytes and their use in treatment of insufficient cardiac function |
| US20050021439A1 (en) * | 1999-04-09 | 2005-01-27 | Pinga Louis J. | Arcade casino and home investment system |
| CA2453438C (en) * | 2001-07-12 | 2016-04-05 | Geron Corporation | Cells of the cardiomyocyte lineage produced from human pluripotent stem cells |
| US20030082153A1 (en) * | 2001-10-22 | 2003-05-01 | The Government Of The United States Of America | Stem cells that transform to beating cardiomyocytes |
| US20060003446A1 (en) * | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
| WO2004094610A2 (en) * | 2003-04-21 | 2004-11-04 | Baylor College Of Medicine | Wnt as a factor for cardiac myogenesis |
| US7452718B2 (en) * | 2004-03-26 | 2008-11-18 | Geron Corporation | Direct differentiation method for making cardiomyocytes from human embryonic stem cells |
| US20050214938A1 (en) * | 2004-03-26 | 2005-09-29 | Gold Joseph D | Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function |
| JP5560393B2 (ja) | 2005-06-22 | 2014-07-23 | アステリアス バイオセラピューティクス インコーポレイテッド | 心筋細胞系列細胞への霊長類多能性幹細胞の分化 |
| EP1913129A4 (en) * | 2005-06-23 | 2009-06-03 | Sinai School Medicine | POPULATIONS OF CARDIOMYOCYTE CELLS |
-
2009
- 2009-03-25 US US12/410,782 patent/US10077428B2/en active Active
- 2009-03-25 JP JP2011502014A patent/JP5801187B2/ja active Active
- 2009-03-25 DK DK09726362.8T patent/DK2273996T3/en active
- 2009-03-25 AU AU2009228354A patent/AU2009228354B2/en active Active
- 2009-03-25 WO PCT/US2009/038220 patent/WO2009120762A2/en not_active Ceased
- 2009-03-25 EP EP09726362.8A patent/EP2273996B8/en active Active
- 2009-03-25 CA CA2717962A patent/CA2717962C/en active Active
-
2010
- 2010-09-21 IL IL208334A patent/IL208334A/en active IP Right Grant
-
2015
- 2015-08-27 IL IL240870A patent/IL240870B/en active IP Right Grant
-
2018
- 2018-08-09 US US16/059,647 patent/US10947506B2/en active Active
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