CA2717962C - Human cardiovascular progenitor cells - Google Patents

Human cardiovascular progenitor cells Download PDF

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Publication number
CA2717962C
CA2717962C CA2717962A CA2717962A CA2717962C CA 2717962 C CA2717962 C CA 2717962C CA 2717962 A CA2717962 A CA 2717962A CA 2717962 A CA2717962 A CA 2717962A CA 2717962 C CA2717962 C CA 2717962C
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Prior art keywords
cells
progenitor cells
human
population
cardiomyocytes
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CA2717962A
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English (en)
French (fr)
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CA2717962A1 (en
Inventor
Lei Yang
Steven Kattman
Gordon Keller
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Icahn School of Medicine at Mount Sinai
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Mount Sinai School of Medicine
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA2717962A 2008-03-27 2009-03-25 Human cardiovascular progenitor cells Active CA2717962C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4004908P 2008-03-27 2008-03-27
US61/040,049 2008-03-27
PCT/US2009/038220 WO2009120762A2 (en) 2008-03-27 2009-03-25 Human cardiovascular progenitor cells

Publications (2)

Publication Number Publication Date
CA2717962A1 CA2717962A1 (en) 2009-10-01
CA2717962C true CA2717962C (en) 2019-05-14

Family

ID=41114664

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2717962A Active CA2717962C (en) 2008-03-27 2009-03-25 Human cardiovascular progenitor cells

Country Status (8)

Country Link
US (2) US10077428B2 (enExample)
EP (1) EP2273996B8 (enExample)
JP (1) JP5801187B2 (enExample)
AU (1) AU2009228354B2 (enExample)
CA (1) CA2717962C (enExample)
DK (1) DK2273996T3 (enExample)
IL (2) IL208334A (enExample)
WO (1) WO2009120762A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2126045A4 (en) * 2007-01-30 2010-05-26 Univ Georgia EARLY MESODERM CELLS, STABLE POPULATION OF MESENDODERM CELLS WITH THE ABILITY TO GENERATE ENDODERM AND MESODERM CELL LINES AND MULTIPOTENTIAL MIGRATION CELLS
EP3255142A1 (en) * 2009-10-19 2017-12-13 Cellular Dynamics International, Inc. Cardiomyocyte production
WO2011090684A2 (en) * 2009-12-29 2011-07-28 Cornell University Methods for developing endothelial cells from pluripotent cells and endothelial cells derived
WO2011091944A1 (en) * 2010-01-26 2011-08-04 Université Libre de Bruxelles Tools for isolating and following cardiovascular progenitor cells
AU2010355614B2 (en) 2010-06-13 2015-07-02 Institute Of Biophysics, Chinese Academy Of Sciences Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof
US9181529B2 (en) 2010-10-19 2015-11-10 Cellular Dynamics International, Inc. Titration of differentiation medium components
US20140045265A1 (en) * 2011-02-16 2014-02-13 Salk Institute For Biological Studies Robust and efficient differentiation of human pluripotent stem cells to multipotent vascular progenitors
CA2831609C (en) 2011-03-30 2019-06-11 Cellular Dynamics International, Inc. Priming of pluripotent stem cells for neural differentiation
GB201109882D0 (en) 2011-06-13 2011-07-27 Cambridge Entpr Ltd Population of smooth muscle cells of specific embryonic lineages
GB201121101D0 (en) * 2011-12-08 2012-01-18 Nhs Blood & Transplant A method of preparing isolated cells and uses
EP2826855B1 (en) * 2012-03-15 2018-08-29 iHeart Japan Corporation Myocardial sheet
CA2886396C (en) * 2012-07-23 2023-08-22 Institute Of Biophysics, Chinese Academy Of Sciences Method for inducing pluripotent stem cells to differentiate into ventricular cardiomyocytes in vitro
WO2014192925A1 (ja) * 2013-05-31 2014-12-04 ｉＨｅａｒｔ Ｊａｐａｎ株式会社 効率的な内皮細胞の誘導方法
AU2014275130B2 (en) 2013-06-05 2019-09-12 Reverse Bioengineering, Inc. Compositions and methods for induced tissue regeneration in mammalian species
HK1220992A1 (zh) * 2013-09-13 2017-05-19 大学健康网络 用於产生心外膜细胞的方法和组合物
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
GB201412554D0 (en) * 2014-07-15 2014-08-27 Cambridge Entpr Ltd In vitro mesodermal differentiation
JP2018510649A (ja) 2015-02-17 2018-04-19 ユニバーシティー ヘルス ネットワーク 洞房結節様ペースメーカー心筋細胞および心室様心筋細胞を作製および使用するための方法
CN115433707A (zh) 2015-12-07 2022-12-06 再生疗法有限公司 用于重新衍生不同的多能干细胞衍生的褐色脂肪细胞的方法
US10612002B2 (en) 2016-02-19 2020-04-07 University Of Washington Human pluripotent stem cell derived endocardial endothelium
US20190017029A1 (en) * 2016-02-25 2019-01-17 The J. David Gladstone Institutes, a testament trust established under the Will of J. David Generation of Expandable Cardiovascular Progenitor Cells
US20230265391A1 (en) * 2020-05-08 2023-08-24 University Health Network Methods and compositions for making and using endocardial cells
CN119384700A (zh) 2022-04-15 2025-01-28 艾斯本神经科学公司 细胞分化状态的分类方法和分化细胞的相关组合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874301A (en) 1994-11-21 1999-02-23 National Jewish Center For Immunology And Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5919449A (en) 1995-05-30 1999-07-06 Diacrin, Inc. Porcine cardiomyocytes and their use in treatment of insufficient cardiac function
US20050021439A1 (en) 1999-04-09 2005-01-27 Pinga Louis J. Arcade casino and home investment system
EP1412479A4 (en) 2001-07-12 2004-07-28 Geron Corp CELLS WITH CARDIOMYOCYTE GENERATION PRODUCED FROM HUMAN PLURIPOTENT STEM CELLS
US20030082153A1 (en) 2001-10-22 2003-05-01 The Government Of The United States Of America Stem cells that transform to beating cardiomyocytes
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
US20050043260A1 (en) 2003-04-21 2005-02-24 Baylor College Of Medicine Wnt as a factor for cardiac myogenesis
US7452718B2 (en) * 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
US20050214938A1 (en) * 2004-03-26 2005-09-29 Gold Joseph D Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
KR20130099253A (ko) 2005-06-22 2013-09-05 제론 코포레이션 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화
EP1913129A4 (en) * 2005-06-23 2009-06-03 Sinai School Medicine POPULATIONS OF CARDIOMYOCYTE CELLS

Also Published As

Publication number Publication date
CA2717962A1 (en) 2009-10-01
JP2011517563A (ja) 2011-06-16
IL208334A0 (en) 2010-12-30
IL208334A (en) 2015-09-24
WO2009120762A3 (en) 2009-12-30
WO2009120762A2 (en) 2009-10-01
EP2273996A2 (en) 2011-01-19
IL240870B (en) 2019-08-29
EP2273996B8 (en) 2017-04-26
AU2009228354A1 (en) 2009-10-01
JP5801187B2 (ja) 2015-10-28
EP2273996B1 (en) 2017-02-22
EP2273996A4 (en) 2012-02-15
US20090269314A1 (en) 2009-10-29
DK2273996T3 (en) 2017-03-27
US10077428B2 (en) 2018-09-18
US10947506B2 (en) 2021-03-16
AU2009228354B2 (en) 2015-01-22
US20180362931A1 (en) 2018-12-20
IL240870A0 (en) 2015-10-29

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