DK2273996T3 - HUMAN CARDIOVASCULAR PROGENITOR CELLS - Google Patents

HUMAN CARDIOVASCULAR PROGENITOR CELLS Download PDF

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Publication number
DK2273996T3
DK2273996T3 DK09726362.8T DK09726362T DK2273996T3 DK 2273996 T3 DK2273996 T3 DK 2273996T3 DK 09726362 T DK09726362 T DK 09726362T DK 2273996 T3 DK2273996 T3 DK 2273996T3
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cells
human
population
progenitor cells
dkk1
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DK09726362.8T
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Danish (da)
English (en)
Inventor
Gordon Keller
Lei Yang
Steven Kattman
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Icahn School Med Mount Sinai
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657Cardiomyocytes; Heart cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/115Basic fibroblast growth factor (bFGF, FGF-2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/155Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/16Activin; Inhibin; Mullerian inhibiting substance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/165Vascular endothelial growth factor [VEGF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40Regulators of development
    • C12N2501/415Wnt; Frizzeled
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK09726362.8T 2008-03-27 2009-03-25 HUMAN CARDIOVASCULAR PROGENITOR CELLS DK2273996T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4004908P 2008-03-27 2008-03-27
PCT/US2009/038220 WO2009120762A2 (en) 2008-03-27 2009-03-25 Human cardiovascular progenitor cells

Publications (1)

Publication Number Publication Date
DK2273996T3 true DK2273996T3 (en) 2017-03-27

Family

ID=41114664

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09726362.8T DK2273996T3 (en) 2008-03-27 2009-03-25 HUMAN CARDIOVASCULAR PROGENITOR CELLS

Country Status (8)

Country Link
US (2) US10077428B2 (enExample)
EP (1) EP2273996B8 (enExample)
JP (1) JP5801187B2 (enExample)
AU (1) AU2009228354B2 (enExample)
CA (1) CA2717962C (enExample)
DK (1) DK2273996T3 (enExample)
IL (2) IL208334A (enExample)
WO (1) WO2009120762A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008211103B2 (en) * 2007-01-30 2014-05-08 University Of Georgia Research Foundation, Inc. Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (MMC)
CA2777552C (en) 2009-10-19 2019-05-21 Cellular Dynamics International, Inc. Cardiomyocyte production
US20120301443A1 (en) * 2009-12-29 2012-11-29 Cornell University Methods for developing endothelial cells from pluripotent cells and endothelial cells derived
US20120301445A1 (en) * 2010-01-26 2012-11-29 Universite Libre De Bruxelles Tools for isolating and following cardiovascular progenitor cells
AU2010355614B2 (en) 2010-06-13 2015-07-02 Institute Of Biophysics, Chinese Academy Of Sciences Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof
US9181529B2 (en) 2010-10-19 2015-11-10 Cellular Dynamics International, Inc. Titration of differentiation medium components
US20140045265A1 (en) * 2011-02-16 2014-02-13 Salk Institute For Biological Studies Robust and efficient differentiation of human pluripotent stem cells to multipotent vascular progenitors
US9487752B2 (en) 2011-03-30 2016-11-08 Cellular Dynamics International, Inc. Priming of pluripotent stem cells for neural differentiation
GB201109882D0 (en) * 2011-06-13 2011-07-27 Cambridge Entpr Ltd Population of smooth muscle cells of specific embryonic lineages
GB201121101D0 (en) * 2011-12-08 2012-01-18 Nhs Blood & Transplant A method of preparing isolated cells and uses
EP2826855B1 (en) * 2012-03-15 2018-08-29 iHeart Japan Corporation Myocardial sheet
EP2891712A4 (en) * 2012-07-23 2016-04-06 Inst Biophysics Cn Acad Sci METHOD FOR INDUCTING PLURIPOTENTAL STEM CELLS FOR DIFFERENTIATING VENTRICULAR IN MYOCYTES IN VITRO
JP5842289B2 (ja) * 2013-05-31 2016-01-13 iHeart Japan株式会社 効率的な内皮細胞の誘導方法
EP3003290B1 (en) 2013-06-05 2021-03-10 AgeX Therapeutics, Inc. Compositions for use in the treatment of wounds in mammalian species
AU2014321101B2 (en) * 2013-09-13 2020-12-03 University Health Network Methods and compositions for generating epicardium cells
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
GB201412554D0 (en) * 2014-07-15 2014-08-27 Cambridge Entpr Ltd In vitro mesodermal differentiation
HK1248270A1 (zh) 2015-02-17 2018-10-12 大学健康网路 制备和使用窦房结样起搏器心肌细胞和心室样心肌细胞的方法
JP2018536438A (ja) 2015-12-07 2018-12-13 バイオタイム,インコーポレーテッド 多様な多能性幹細胞から誘導された褐色脂肪細胞の再誘導のための方法
US10612002B2 (en) 2016-02-19 2020-04-07 University Of Washington Human pluripotent stem cell derived endocardial endothelium
WO2017147381A1 (en) * 2016-02-25 2017-08-31 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Generation of expandable cardiovascular progenitor cells
JP2023524572A (ja) * 2020-05-08 2023-06-12 ユニバーシティー ヘルス ネットワーク 心内膜細胞を作製および使用するための方法および組成物
WO2023201361A1 (en) 2022-04-15 2023-10-19 Aspen Neuroscience, Inc. Methods of classifying the differentiation state of cells and related compositions of differentiated cells

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874301A (en) 1994-11-21 1999-02-23 National Jewish Center For Immunology And Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5919449A (en) * 1995-05-30 1999-07-06 Diacrin, Inc. Porcine cardiomyocytes and their use in treatment of insufficient cardiac function
US20050021439A1 (en) * 1999-04-09 2005-01-27 Pinga Louis J. Arcade casino and home investment system
IL159580A0 (en) * 2001-07-12 2004-06-01 Geron Corp Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
US20030082153A1 (en) 2001-10-22 2003-05-01 The Government Of The United States Of America Stem cells that transform to beating cardiomyocytes
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
WO2004094610A2 (en) * 2003-04-21 2004-11-04 Baylor College Of Medicine Wnt as a factor for cardiac myogenesis
US20050214938A1 (en) * 2004-03-26 2005-09-29 Gold Joseph D Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
US7452718B2 (en) * 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
KR20130099253A (ko) 2005-06-22 2013-09-05 제론 코포레이션 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화
AU2006262098B2 (en) 2005-06-23 2011-03-17 Mount Sinai School Of Medicine Of New York University Cardiomyocyte cell populations

Also Published As

Publication number Publication date
EP2273996B8 (en) 2017-04-26
US10947506B2 (en) 2021-03-16
IL240870A0 (en) 2015-10-29
EP2273996A4 (en) 2012-02-15
CA2717962A1 (en) 2009-10-01
JP2011517563A (ja) 2011-06-16
US20180362931A1 (en) 2018-12-20
US20090269314A1 (en) 2009-10-29
EP2273996A2 (en) 2011-01-19
AU2009228354A1 (en) 2009-10-01
JP5801187B2 (ja) 2015-10-28
EP2273996B1 (en) 2017-02-22
CA2717962C (en) 2019-05-14
IL208334A0 (en) 2010-12-30
AU2009228354B2 (en) 2015-01-22
WO2009120762A3 (en) 2009-12-30
IL208334A (en) 2015-09-24
IL240870B (en) 2019-08-29
WO2009120762A2 (en) 2009-10-01
US10077428B2 (en) 2018-09-18

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