JP2009502140A - 光活性化陽イオンチャネルおよびその使用 - Google Patents

光活性化陽イオンチャネルおよびその使用 Download PDF

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JP2009502140A
JP2009502140A JP2008523046A JP2008523046A JP2009502140A JP 2009502140 A JP2009502140 A JP 2009502140A JP 2008523046 A JP2008523046 A JP 2008523046A JP 2008523046 A JP2008523046 A JP 2008523046A JP 2009502140 A JP2009502140 A JP 2009502140A
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light
cation channel
protein
cells
cell
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JP2009502140A5 (https=
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ボイデン、エドワード、エス．
ダイセロス、カール
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ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2013038666A1 (ja) * 2011-09-12 2015-03-23 国立大学法人東北大学 ラット脳内光誘発けいれんモデル
JP2016509487A (ja) * 2012-11-21 2016-03-31 サーキット セラピューティクス， インコーポレイテッド 光遺伝学的治療のためのシステムおよび方法
JP2019047763A (ja) * 2017-09-12 2019-03-28 国立大学法人 名古屋工業大学 ロドプシンホスホジエステラーゼ
JP2022110036A (ja) * 2015-12-09 2022-07-28 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 機能的脳回路解析の方法
JP2024509088A (ja) * 2021-02-24 2024-02-29 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 脳への聴覚入力を回復または増強するための事前形成された神経組織

Families Citing this family (175)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003249318A1 (en) 2002-07-18 2004-02-09 The General Hospital Corp. Method for augmenting vision in persons suffering from photoreceptor cell degeneration
WO2007024290A2 (en) * 2005-04-28 2007-03-01 University Of Illinois At Chicago Nanoscale neuromodulating platform for retina neuron activation apparatus and method
US9399145B2 (en) 2005-04-28 2016-07-26 The Board Of Trustees Of The University Of Illinois Nanoscale neuromodulating platform for retina neuron activation apparatus and method
US8926959B2 (en) * 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
US10052497B2 (en) * 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
EP1919497B1 (en) 2005-07-22 2020-02-12 The Board of Trustees of the Leland Stanford Junior University Light-activated cation channel and uses thereof
US9238150B2 (en) * 2005-07-22 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Optical tissue interface method and apparatus for stimulating cells
US7736382B2 (en) 2005-09-09 2010-06-15 Lockheed Martin Corporation Apparatus for optical stimulation of nerves and other animal tissue
US8929973B1 (en) 2005-10-24 2015-01-06 Lockheed Martin Corporation Apparatus and method for characterizing optical sources used with human and animal tissues
US8012189B1 (en) 2007-01-11 2011-09-06 Lockheed Martin Corporation Method and vestibular implant using optical stimulation of nerves
US8475506B1 (en) 2007-08-13 2013-07-02 Lockheed Martin Corporation VCSEL array stimulator apparatus and method for light stimulation of bodily tissues
US20080077200A1 (en) * 2006-09-21 2008-03-27 Aculight Corporation Apparatus and method for stimulation of nerves and automated control of surgical instruments
US8709078B1 (en) 2011-08-03 2014-04-29 Lockheed Martin Corporation Ocular implant with substantially constant retinal spacing for transmission of nerve-stimulation light
US8956396B1 (en) 2005-10-24 2015-02-17 Lockheed Martin Corporation Eye-tracking visual prosthetic and method
US8945197B1 (en) 2005-10-24 2015-02-03 Lockheed Martin Corporation Sight-restoring visual prosthetic and method using infrared nerve-stimulation light
US8792978B2 (en) 2010-05-28 2014-07-29 Lockheed Martin Corporation Laser-based nerve stimulators for, E.G., hearing restoration in cochlear prostheses and method
US8492150B2 (en) * 2006-02-03 2013-07-23 President And Fellows Of Harvard College Engineered cell growth on polymeric films and biotechnological applications thereof
EP2019588A4 (en) * 2006-05-04 2010-11-24 Univ Wayne State RESTORATION OF VISUAL RESPONSES BY IN VIVO ADMINISTRATION OF NUCLEIC ACIDS OF RHODOPSIN
EP1891976A1 (en) * 2006-08-23 2008-02-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research Use of light sensitive genes
US8498699B2 (en) 2008-10-03 2013-07-30 Lockheed Martin Company Method and nerve stimulator using simultaneous electrical and optical signals
US8996131B1 (en) 2006-09-28 2015-03-31 Lockheed Martin Corporation Apparatus and method for managing chronic pain with infrared light sources and heat
WO2008045506A2 (en) * 2006-10-10 2008-04-17 President And Fellows Of Harvard College Biopolymer structures
US8314119B2 (en) 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
US20090110933A1 (en) * 2007-10-30 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems and devices related to nitric oxide releasing materials
US20110190604A1 (en) * 2006-12-22 2011-08-04 Hyde Roderick A Nitric oxide sensors and systems
US8642093B2 (en) * 2007-10-30 2014-02-04 The Invention Science Fund I, Llc Methods and systems for use of photolyzable nitric oxide donors
US20090112197A1 (en) * 2007-10-30 2009-04-30 Searete Llc Devices configured to facilitate release of nitric oxide
WO2008086470A1 (en) 2007-01-10 2008-07-17 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US7883536B1 (en) 2007-01-19 2011-02-08 Lockheed Martin Corporation Hybrid optical-electrical probes
EP1953579B1 (en) * 2007-02-05 2010-01-13 Olympus Corporation Scanning laser microscope
WO2008101128A1 (en) 2007-02-14 2008-08-21 The Board Of Trustees Of The Leland Stanford Junior University System, method and applications involving identification of biological circuits such as neurological characteristics
WO2008106694A2 (en) 2007-03-01 2008-09-04 The Board Of Trustees Of The Leland Stanford Junior University Systems, methods and compositions for optical stimulation of target cells
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
MX2009010000A (es) 2007-03-19 2010-03-17 Insuline Medical Ltd Dispositivo para el suministro de farmaco.
US8910638B2 (en) 2007-05-09 2014-12-16 Massachusetts Institute Of Technology Methods and apparatus for high-throughput neural screening
US20090210039A1 (en) * 2007-05-09 2009-08-20 Boyden Edward S Prosthetic system for therapeutic optical activation and silencing of genetically-targeted neurons
US20140324138A1 (en) * 2007-05-09 2014-10-30 Massachusetts Institute Of Technology Wirelessly-powered illumination of biological tissue
US8349262B2 (en) * 2007-10-30 2013-01-08 The Invention Science Fund I, Llc Nitric oxide permeable housings
US20090112055A1 (en) * 2007-10-30 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Sleeves configured to facilitate release of nitric oxide
US8980332B2 (en) 2007-10-30 2015-03-17 The Invention Science Fund I, Llc Methods and systems for use of photolyzable nitric oxide donors
US8877508B2 (en) 2007-10-30 2014-11-04 The Invention Science Fund I, Llc Devices and systems that deliver nitric oxide
US20090112193A1 (en) * 2007-10-30 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems and devices that utilize photolyzable nitric oxide donors
US20110182970A1 (en) * 2007-10-30 2011-07-28 Hyde Roderick A Nitric oxide sensors and systems
US10080823B2 (en) * 2007-10-30 2018-09-25 Gearbox Llc Substrates for nitric oxide releasing devices
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
US10035027B2 (en) * 2007-10-31 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Device and method for ultrasonic neuromodulation via stereotactic frame based technique
US9011508B2 (en) 2007-11-30 2015-04-21 Lockheed Martin Corporation Broad wavelength profile to homogenize the absorption profile in optical stimulation of nerves
US8409133B2 (en) 2007-12-18 2013-04-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
JP2009213430A (ja) * 2008-03-12 2009-09-24 Tohoku Univ 網膜外層の障害を治療するための新規融合タンパク質
US20110022131A1 (en) * 2008-04-01 2011-01-27 Pelvipharm Method for Restoring an Ejaculatory Failure
DE102008020152B4 (de) * 2008-04-22 2012-04-05 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle
MY169771A (en) 2008-04-23 2019-05-15 Univ Leland Stanford Junior Systems, methods and compositions for optical stimulation of target cells
EP2910637A1 (en) 2008-05-20 2015-08-26 University of Florida Research Foundation, Inc. Vectors for delivery of light-sensitive proteins and methods of use
WO2010011407A2 (en) * 2008-05-23 2010-01-28 President And Fellows Of Harvard College Methods of generating patterned soft substrates and uses thereof
WO2009148946A2 (en) 2008-05-29 2009-12-10 The Board Of Trustees Of The Leland Stanford Junior University Cell line, system and method for optical control of secondary messengers
AU2014233591B2 (en) * 2008-05-29 2016-09-22 The Board Of Trustees Of The Leland Stanford Junior University Cell line, system and method for optical control of secondary messengers
JP2011525130A (ja) 2008-06-17 2011-09-15 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ 光伝送素子を用いた標的細胞の光刺激のための方法、システム、および装置
EP2303405A4 (en) * 2008-06-17 2017-12-27 The Board of Trustees of the Leland Stanford Junior University Apparatus and methods for controlling cellular development
WO2010006049A1 (en) 2008-07-08 2010-01-14 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
US9846313B2 (en) * 2008-09-25 2017-12-19 The Trustees Of Columbia University In The City Of New York Devices, apparatus and method for providing photostimulation and imaging of structures
CA2743027C (en) 2008-11-07 2016-04-12 Insuline Medical Ltd. Device and method for drug delivery
NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
DE102009061008B4 (de) 2009-03-20 2014-09-25 Retina Implant Ag Verwendung einer Testvorrichtung und Verfahren zum Test von Zellen, Zellkulturen und/oder organotypischen Zellverbänden
US20100247446A1 (en) * 2009-03-24 2010-09-30 Olympus Corporation Method and system for analyzing optical signal
US9089698B2 (en) * 2009-04-17 2015-07-28 The Regents Of The University Of California Method and apparatus for optogenetic treatment of blindness including retinitis pigmentosa
WO2010127280A1 (en) * 2009-05-01 2010-11-04 President And Fellows Of Harvard College High throughput assays for determining contractile function and devices for use therein
CN102686147B (zh) 2009-11-05 2016-01-20 格雷特巴奇有限公司 波导神经接口装置
US20110125078A1 (en) * 2009-11-25 2011-05-26 Medtronic, Inc. Optical stimulation therapy
AU2011220367B2 (en) 2010-02-26 2016-05-12 Cornell University Retina prosthesis
US9545422B2 (en) * 2010-03-01 2017-01-17 The Regents Of The University Of California Methods of inducing photosensitivity by targeting channelrhodopsin-2 and halorhodopsin to subcellular regions of retinal ganglion cells
WO2011116238A2 (en) 2010-03-17 2011-09-22 The Board Of Trustees Of The Leland Stanford Junior University. Light-sensitive ion-passing molecules
WO2011127088A2 (en) 2010-04-05 2011-10-13 Eos Neuroscience, Inc. Methods and compositions for decreasing chronic pain
WO2011140279A1 (en) * 2010-05-04 2011-11-10 Wayne State University Aav-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
MX2013002375A (es) 2010-08-31 2013-10-07 Univ Cornell Protesis de retina.
US9302103B1 (en) 2010-09-10 2016-04-05 Cornell University Neurological prosthesis
CN103180321A (zh) 2010-09-23 2013-06-26 Abbvie公司 氮杂金刚烷衍生物的一水合物
GB2498325B (en) 2010-10-15 2018-05-02 Eos Neuroscience Inc Engineered human GRM6 enhancer sequence for use in eye therapies
WO2012054484A1 (en) * 2010-10-18 2012-04-26 The Research Foundation Of State University Of New York Optical control of cardiac function
CN106106368A (zh) 2010-11-05 2016-11-16 斯坦福大学托管董事会 光控cns功能障碍
CN106422081B (zh) 2010-11-05 2019-06-21 斯坦福大学托管董事会 用于光遗传学方法的光的上转换
WO2012061679A2 (en) * 2010-11-05 2012-05-10 The Board Of Trustees Of The Leland Stanford Junior University Light-activated chimeric opsins and methods of using the same
CN106376525A (zh) 2010-11-05 2017-02-08 斯坦福大学托管董事会 记忆功能的控制和表征
ES2684307T3 (es) 2010-11-05 2018-10-02 The Board Of Trustees Of The Leland Stanford Junior University Proteínas estabilizadas de tipo opsina de función escalonada y métodos de uso de las mismas
AU2011323235B2 (en) 2010-11-05 2015-10-29 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of reward-related behaviors
US20120214188A1 (en) * 2010-11-12 2012-08-23 Nathan Klapoetke Light-activated ion channel molecules and uses thereof
US8957028B2 (en) 2010-11-13 2015-02-17 Massachusetts Institute Of Technology Red-shifted opsin molecules and uses thereof
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
HRP20171334T1 (hr) 2011-04-22 2017-11-17 The Regents Of The University Of California Virioni adeno-povezanog virusa s kapsid varijantom i postupci njihove upotrebe
US9592398B2 (en) 2011-05-12 2017-03-14 Medtronic, Inc. Leadless implantable medical device with osmotic pump
JP6117206B2 (ja) 2011-08-25 2017-04-19 コーネル ユニヴァーシティー 機械視覚のための網膜符号化器
US9199080B2 (en) 2011-09-12 2015-12-01 Okuvision Gmbh Method for treating an eye
WO2013056037A1 (en) 2011-10-13 2013-04-18 The Cleveland Clinic Foundation Estimation of neural response for optical stimulation
ES2801679T3 (es) 2011-11-12 2021-01-12 Massachusetts Inst Technology Canalrodopsinas para el control óptico de células
CA2859364C (en) 2011-12-16 2019-05-07 The Board Of Trustees Of The Leland Stanford Junior University Opsin polypeptides and methods of use thereof
US9265969B2 (en) * 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
EP3205374B1 (en) 2012-02-21 2019-03-27 The Board of Trustees of The Leland Stanford Junior University Compositions for treating neurogenic disorders of the pelvic floor
AU2013230112A1 (en) 2012-03-05 2014-09-25 Wayne State University Identification of channelrhodopsin-2 (Chop2) mutations and methods of use
US20130317572A1 (en) * 2012-05-25 2013-11-28 Boston Scientific Neuromodulation Corporation Low-level laser therapy
CA2900038C (en) * 2013-02-07 2021-02-09 Rocomp Global, Llc Electromagnetic radiation targeting devices, assemblies, systems and methods
JP6594854B2 (ja) 2013-03-15 2019-10-23 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 行動状態の光遺伝学的制御方法
US9636380B2 (en) 2013-03-15 2017-05-02 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of inputs to the ventral tegmental area
AU2014260101B2 (en) 2013-04-29 2018-07-26 Humboldt-Universitat Zu Berlin Devices, systems and methods for optogenetic modulation of action potentials in target cells
EP3033427A4 (en) 2013-08-14 2017-05-31 The Board Of Trustees Of The University Of the Leland Stanford Junior University Compositions and methods for controlling pain
US8843217B1 (en) 2013-09-13 2014-09-23 Lockheed Martin Corporation Combined vestibular and cochlear implant and method
JP6118239B2 (ja) * 2013-11-29 2017-04-19 雅敏 堀 害虫の防除方法及び防除装置
US10392426B2 (en) 2014-02-07 2019-08-27 Massachusetts Institute Of Technology Blue-light-activated ion channel polypeptides and uses thereof
KR101639859B1 (ko) * 2014-03-06 2016-07-14 포항공과대학교 산학협력단 광 자극에 의한 미토콘드리아 활성의 시공간적 가역 조절 방법
US20150283397A1 (en) * 2014-03-27 2015-10-08 Circuit Therapeutics, Inc. System and method for therapeutic management of cough
EP3122761B1 (en) 2014-03-28 2019-03-06 The Board of Trustees of The Leland Stanford Junior University Engineered light-activated anion channel proteins and methods of use thereof
KR101593224B1 (ko) * 2014-06-10 2016-02-12 재단법인 대구경북과학기술원 신경세포 축약 모델링 방법
US10882892B2 (en) 2014-08-05 2021-01-05 Massachusetts Institute Of Technology Channelrhodopsin variants and uses thereof
WO2016070286A1 (en) * 2014-11-07 2016-05-12 The Governors Of The University Of Alberta Bioengineered adipocytes for the light-controlled release of insulin and other peptides
US10377818B2 (en) 2015-01-30 2019-08-13 The Board Of Trustees Of The Leland Stanford Junior University Method of treating glioma
CN112842690B (zh) 2015-04-20 2023-10-17 康奈尔大学 具有维度数据缩减的机器视觉
WO2016209654A1 (en) 2015-06-22 2016-12-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
US11384328B2 (en) 2015-11-18 2022-07-12 President And Fellows Of Harvard College Cartridge-based system for long term culture of cell clusters
US10335607B2 (en) 2016-02-05 2019-07-02 Boston Scientific Neuromodulation Corporation Implantable optical stimulation lead and methods of making and using
KR101887051B1 (ko) * 2016-02-12 2018-08-10 한국과학기술원 오브젝트 탐닉행동을 활용한 동물행동 조절 방법
AU2017256910B2 (en) 2016-04-29 2022-04-07 Centre National De La Recherche Scientifique Optogenetic visual restoration using Chrimson
ES2908467T3 (es) 2016-04-29 2022-04-29 Adverum Biotechnologies Inc Evasión de anticuerpos neutralizantes por un virus adenoasociado recombinante
KR102443267B1 (ko) 2016-06-17 2022-09-14 쏘흐본느 유니베흐시테 제어된 광도로 물체를 비추는 장치 및 관련 방법
WO2018017831A1 (en) 2016-07-21 2018-01-25 Massachusetts Institute Of Technology Dummy-fluorescent protein fusions and methods of use
EP3827812B1 (en) 2016-07-29 2025-10-29 The Regents of the University of California Adeno-associated virus virions with variant capsid and methods of use thereof
CA3034887A1 (en) * 2016-08-29 2018-03-08 Wayne State University Identification of mutations in channelopsin variants having improved light sensitivity and methods of use thereof
CA3040179A1 (en) 2016-10-19 2018-04-26 Adverum Biotechnologies, Inc. Modified aav capsids and uses thereof
US10625072B2 (en) 2016-10-21 2020-04-21 Boston Scientific Neuromodulation Corporation Electrical stimulation methods with optical observation and devices therefor
WO2018085253A1 (en) * 2016-11-01 2018-05-11 Massachusetts Institute Of Technology Transdermal optogenetic peripheral nerve stimulation
WO2018134168A1 (en) 2017-01-17 2018-07-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of expressing a polynucleotide of interest in the cone photoreceptors
JP6827214B2 (ja) * 2017-01-26 2021-02-10 パナソニックＩｐマネジメント株式会社 照明システム、及び、昼行性家禽類の飼育方法
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
US11058889B1 (en) 2017-04-03 2021-07-13 Xiant Technologies, Inc. Method of using photon modulation for regulation of hormones in mammals
US10814140B2 (en) 2017-06-26 2020-10-27 Boston Scientific Neuromodulation Corporation Systems and methods for visualizing and controlling optogenetic stimulation using optical stimulation systems
EP3422065A1 (en) 2017-06-28 2019-01-02 Gensight Biologics Objective, camera and system adapted for optogenetics comprising such objective
WO2019006182A1 (en) 2017-06-30 2019-01-03 The Regents Of The University Of California VIRIONS OF ADENO-ASSOCIATED VIRUSES OF CAPSID VARIANTS AND METHODS OF USE THEREOF
US11542314B2 (en) 2017-09-11 2023-01-03 Massachusetts Institute Of Technology Step-function channelrhodopsins for optical control of cells
EP3684463B1 (en) 2017-09-19 2025-05-14 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement
US11629318B2 (en) 2017-10-20 2023-04-18 President And Fellows Of Harvard College Methods for producing mature adipocytes and methods of use thereof
JP7420710B2 (ja) 2017-10-20 2024-01-23 アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） 組換えａａｖ９由来ベクターの治療有効量の網膜下送達を含む、対象の錐体視細胞において目的のポリヌクレオチドを発現させる方法
US11717686B2 (en) 2017-12-04 2023-08-08 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to facilitate learning and performance
US11478603B2 (en) 2017-12-31 2022-10-25 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
US12280219B2 (en) 2017-12-31 2025-04-22 NeuroLight, Inc. Method and apparatus for neuroenhancement to enhance emotional response
US11135438B2 (en) 2018-01-11 2021-10-05 Boston Scientific Neuromodulation Corporation Methods and systems for stimulation for glial modulation
CN111771210B (zh) 2018-01-11 2024-04-26 健赛特生物技术公司 用于处理由基于事件的光传感器生成的异步信号的方法和装置
WO2019183054A1 (en) 2018-03-23 2019-09-26 Boston Scientific Neuromodulation Corporation Optical stimulation systems with calibration and methods of making and using
US11524174B2 (en) 2018-03-23 2022-12-13 Boston Scientific Neuromodulation Corporation Optical stimulation system with on-demand monitoring and methods of making and using
US11364361B2 (en) 2018-04-20 2022-06-21 Neuroenhancement Lab, LLC System and method for inducing sleep by transplanting mental states
CN113382683A (zh) 2018-09-14 2021-09-10 纽罗因恒思蒙特实验有限责任公司 改善睡眠的系统和方法
US11224743B2 (en) 2018-09-21 2022-01-18 Boston Scientific Neuromodulation Corporation Systems and methods for making and using modular leads for electrical stimulation systems
US12121597B2 (en) 2018-10-19 2024-10-22 The Board Of Trustees Of The University Of Illinois High-intensity focused ultrasound-induced mechanochemical transduction in synthetic elastomers
EP3840824A1 (en) 2018-11-16 2021-06-30 Boston Scientific Neuromodulation Corporation An optical stimulation system with on-demand monitoring and methods of making
CN109444433A (zh) * 2018-12-18 2019-03-08 深圳先进技术研究院 D-丝氨酸作为标志物在制备抑郁症诊断试剂盒中的应用及抑郁症诊断试剂盒
EP3693060A1 (en) 2019-02-05 2020-08-12 Gensight Biologics Method for controlling an optogenetic device using a command law for the radiant power of a light source and associated devices
EP3693061A1 (en) 2019-02-05 2020-08-12 Gensight Biologics Method for controlling an optogenetic device using filtering and associated devices
US20220099540A1 (en) * 2019-03-20 2022-03-31 Ion Diagnostics Llc Methods and systems for assessing bioelectric patterns
TW202532428A (zh) 2019-04-26 2025-08-16 美商愛德維仁生物科技公司 用於玻璃體內遞送之變異體aav蛋白殼
EP3733139A1 (en) 2019-05-02 2020-11-04 Gensight Biologics Viewing apparatus and method for projecting a light signal
CN114786765B (zh) * 2019-09-25 2026-03-20 小利兰·斯坦福大学托管委员会 对眶额皮质的丘脑输入驱动由gaba和未定带介导的全脑频率依赖性抑制
CN111073906A (zh) * 2019-12-10 2020-04-28 天津大学 光遗传与脑啡肽酶基因的结合方法
CA3179895A1 (en) 2020-04-24 2021-10-28 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for preventing induction of immune responses to the transduced cells expressing a transgene product after ocular gene therapy
EP3932940A1 (en) * 2020-07-03 2022-01-05 Rheinische Friedrich-Wilhelms-Universität Bonn Polypeptides for light induced ca2 release and constructs containing the same
CN111840551B (zh) * 2020-07-28 2022-07-19 苏州大学 治疗糖尿病的非侵入式近红外光控的纳米材料
KR20220020108A (ko) 2020-08-11 2022-02-18 삼성전자주식회사 약물 전달 장치 및 약물 전달 장치의 동작 방법
US11806547B2 (en) 2020-09-04 2023-11-07 Boston Scientific Neuromodulation Corporation Stimulation systems with a lens arrangement for light coupling and methods of making and using
US12427332B2 (en) 2021-04-08 2025-09-30 Boston Scientific Neuromodulation Corporation Photobiomodulation system and delivery device and methods of making and using
CN115024274A (zh) * 2022-06-01 2022-09-09 中国人民解放军总医院第一医学中心 一种皮层扩步性抑制动物模型及其模型实验构建方法
AU2023304369A1 (en) 2022-07-07 2025-01-16 Science Corporation Neural interface device
WO2024077287A2 (en) * 2022-10-07 2024-04-11 Mercury Bio, Inc. Methods for actively loading therapeutic molecules into modified extracellular vesicles for targeted delivery to cells
KR102785095B1 (ko) * 2022-12-12 2025-03-24 재단법인대구경북과학기술원 뇌자극을 통한 인지 기능 강화용 동물모델 및 이의 제조방법
EP4398258A3 (en) 2023-01-04 2024-08-28 Boston Scientific Neuromodulation Corporation Systems and methods incorporating a light therapy user interface for optical modulation
CN117929328A (zh) * 2023-03-29 2024-04-26 李梦菡 一种离子通道药物筛选系统
AU2024264802A1 (en) 2023-05-04 2025-11-13 Gensight Biologics Viewing apparatus
AU2024264771A1 (en) 2023-05-04 2025-11-13 Gensight Biologics Method for controlling the illumination of a surface of an object by a projecting unit and associated method and devices

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040080A1 (en) * 2001-08-16 2003-02-27 Gero Miesenbock Bio-synthetic photostimulators and methods of use
WO2003102156A2 (en) * 2002-05-31 2003-12-11 Sloan-Kettering Institute For Cancer Research Heterologous stimulus-gated ion channels and methods of using same
US20030232339A1 (en) * 2002-04-01 2003-12-18 Youmin Shu Human TRPCC cation channel and uses
US20050119315A1 (en) * 1999-03-31 2005-06-02 Cardiome Pharma Corp. Ion channel modulating activity II

Family Cites Families (305)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2968302A (en) 1956-07-20 1961-01-17 Univ Illinois Multibeam focusing irradiator
US3131690A (en) * 1962-10-22 1964-05-05 American Optical Corp Fiber optics devices
US3499437A (en) 1967-03-10 1970-03-10 Ultrasonic Systems Method and apparatus for treatment of organic structures and systems thereof with ultrasonic energy
US3567847A (en) 1969-01-06 1971-03-02 Edgar E Price Electro-optical display system
US4343301A (en) 1979-10-04 1982-08-10 Robert Indech Subcutaneous neural stimulation or local tissue destruction
US4559951A (en) 1982-11-29 1985-12-24 Cardiac Pacemakers, Inc. Catheter assembly
US4616231A (en) 1984-03-26 1986-10-07 Hughes Aircraft Company Narrow-band beam steering system
FR2580277B1 (fr) * 1985-04-15 1988-06-10 Oreal Nouveaux derives naphtaleniques a action retinoique, le ur procede de preparation et compositions medicamenteuse et cosmetique les contenant
US4865042A (en) 1985-08-16 1989-09-12 Hitachi, Ltd. Ultrasonic irradiation system
US4876333A (en) 1985-10-15 1989-10-24 Ciba-Geigy Corporation β-crystalline modification of diasazo acid dyestuff
US5041224A (en) 1988-03-28 1991-08-20 Canon Kabushiki Kaisha Ion permeable membrane and ion transport method by utilizing said membrane
US5082670A (en) 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
JP2882818B2 (ja) * 1989-09-08 1999-04-12 株式会社エス・エル・ティ・ジャパン レーザ光の照射装置
CA2028261C (en) 1989-10-28 1995-01-17 Won Suck Yang Non-invasive method and apparatus for measuring blood glucose concentration
US5032123A (en) * 1989-12-28 1991-07-16 Cordis Corporation Laser catheter with radially divergent treatment beam
JP4236698B2 (ja) 1990-11-26 2009-03-11 ジェネティックス インスティチュート，リミテッド ライアビリティ カンパニー 宿主細胞でのｐａｃｅの発現およびその使用法
US5550316A (en) 1991-01-02 1996-08-27 Fox Chase Cancer Center Transgenic animal model system for human cutaneous melanoma
US6497872B1 (en) 1991-07-08 2002-12-24 Neurospheres Holdings Ltd. Neural transplantation using proliferated multipotent neural stem cells and their progeny
US5249575A (en) 1991-10-21 1993-10-05 Adm Tronics Unlimited, Inc. Corona discharge beam thermotherapy system
SE9103752D0 (sv) 1991-12-18 1991-12-18 Astra Ab New compounds
US5670113A (en) * 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
US5739273A (en) * 1992-02-12 1998-04-14 Yale University Transmembrane polypeptide and methods of use
US5460954A (en) 1992-04-01 1995-10-24 Cheil Foods & Chemicals, Inc. Production of human proinsulin using a novel vector system
US5330515A (en) * 1992-06-17 1994-07-19 Cyberonics, Inc. Treatment of pain by vagal afferent stimulation
US5382516A (en) 1992-09-15 1995-01-17 Schleicher & Schuell, Inc. Method and devices for delivery of substrate for the detection of enzyme-linked, membrane-based binding assays
US5527695A (en) 1993-01-29 1996-06-18 Purdue Research Foundation Controlled modification of eukaryotic genomes
CA2156251A1 (en) * 1993-03-25 1994-09-29 George J. Turner Expression of heterologous polypeptides in halobacteria
JP3128386B2 (ja) 1993-04-07 2001-01-29 三洋電機株式会社 神経モデル素子
US5411540A (en) 1993-06-03 1995-05-02 Massachusetts Institute Of Technology Method and apparatus for preferential neuron stimulation
GB2278783A (en) * 1993-06-11 1994-12-14 Daniel Shellon Gluck Method of magnetically stimulating neural cells
US6346101B1 (en) 1993-07-19 2002-02-12 Research Foundation Of City College Of New York Photon-mediated introduction of biological materials into cells and/or cellular components
US5445608A (en) 1993-08-16 1995-08-29 James C. Chen Method and apparatus for providing light-activated therapy
JPH07171162A (ja) 1993-09-07 1995-07-11 Olympus Optical Co Ltd レーザプローブ
US6251100B1 (en) 1993-09-24 2001-06-26 Transmedica International, Inc. Laser assisted topical anesthetic permeation
US5470307A (en) 1994-03-16 1995-11-28 Lindall; Arnold W. Catheter system for controllably releasing a therapeutic agent at a remote tissue site
CA2187626C (en) 1994-04-13 2009-11-03 Michael G. Kaplitt Aav-mediated delivery of dna to cells of the nervous system
US6436908B1 (en) * 1995-05-30 2002-08-20 Duke University Use of exogenous β-adrenergic receptor and β-adrenergic receptor kinase gene constructs to enhance myocardial function
US5495541A (en) * 1994-04-19 1996-02-27 Murray; Steven C. Optical delivery device with high numerical aperture curved waveguide
US5503737A (en) 1994-07-25 1996-04-02 Ingersoll-Rand Company Air inflow restrictor for disc filters
US5807285A (en) 1994-08-18 1998-09-15 Ethicon-Endo Surgery, Inc. Medical applications of ultrasonic energy
US5520188A (en) 1994-11-02 1996-05-28 Focus Surgery Inc. Annular array transducer
US5795581A (en) 1995-03-31 1998-08-18 Sandia Corporation Controlled release of molecular components of dendrimer/bioactive complexes
US6334846B1 (en) * 1995-03-31 2002-01-01 Kabushiki Kaisha Toshiba Ultrasound therapeutic apparatus
WO1996032076A1 (en) 1995-04-11 1996-10-17 Baxter Internatonal Inc. Tissue implant systems
US6342379B1 (en) 1995-06-07 2002-01-29 The Regents Of The University Of California Detection of transmembrane potentials by optical methods
US6480743B1 (en) 2000-04-05 2002-11-12 Neuropace, Inc. System and method for adaptive brain stimulation
US5755750A (en) * 1995-11-13 1998-05-26 University Of Florida Method and apparatus for selectively inhibiting activity in nerve fibers
US5722426A (en) * 1996-02-26 1998-03-03 Kolff; Jack Coronary light probe and method of use
US5703985A (en) * 1996-04-29 1997-12-30 Eclipse Surgical Technologies, Inc. Optical fiber device and method for laser surgery procedures
US5898058A (en) 1996-05-20 1999-04-27 Wellman, Inc. Method of post-polymerization stabilization of high activity catalysts in continuous polyethylene terephthalate production
US5939320A (en) 1996-05-20 1999-08-17 New York University G-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
US20040076613A1 (en) 2000-11-03 2004-04-22 Nicholas Mazarakis Vector system
US7732129B1 (en) 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
US5741316A (en) * 1996-12-02 1998-04-21 Light Sciences Limited Partnership Electromagnetic coil configurations for power transmission through tissue
US5756351A (en) * 1997-01-13 1998-05-26 The Regents Of The University Of California Biomolecular optical sensors
US5782896A (en) * 1997-01-29 1998-07-21 Light Sciences Limited Partnership Use of a shape memory alloy to modify the disposition of a device within an implantable medical probe
US5904659A (en) 1997-02-14 1999-05-18 Exogen, Inc. Ultrasonic treatment for wounds
US5816256A (en) 1997-04-17 1998-10-06 Bioanalytical Systems, Inc. Movement--responsive system for conducting tests on freely-moving animals
EP0969876A2 (en) 1997-04-17 2000-01-12 Paola Leone Delivery system for gene therapy to the brain
US7276488B2 (en) 1997-06-04 2007-10-02 Oxford Biomedica (Uk) Limited Vector system
US5984861A (en) 1997-09-29 1999-11-16 Boston Scientific Corporation Endofluorescence imaging module for an endoscope
US6647296B2 (en) 1997-10-27 2003-11-11 Neuropace, Inc. Implantable apparatus for treating neurological disorders
US6016449A (en) 1997-10-27 2000-01-18 Neuropace, Inc. System for treatment of neurological disorders
US6597954B1 (en) 1997-10-27 2003-07-22 Neuropace, Inc. System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes
US6790652B1 (en) 1998-01-08 2004-09-14 Bioimage A/S Method and apparatus for high density format screening for bioactive molecules
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
WO1999051143A1 (en) * 1998-04-07 1999-10-14 Windy Hill Technology, Inc. Methods and devices for the localization of lesions in solid tissue
US6319241B1 (en) * 1998-04-30 2001-11-20 Medtronic, Inc. Techniques for positioning therapy delivery elements within a spinal cord or a brain
US6108081A (en) 1998-07-20 2000-08-22 Battelle Memorial Institute Nonlinear vibrational microscopy
WO2000011155A1 (en) 1998-08-19 2000-03-02 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for genomic modification
US6377842B1 (en) 1998-09-22 2002-04-23 Aurora Optics, Inc. Method for quantitative measurement of fluorescent and phosphorescent drugs within tissue utilizing a fiber optic probe
US6253109B1 (en) * 1998-11-05 2001-06-26 Medtronic Inc. System for optimized brain stimulation
US7211054B1 (en) * 1998-11-06 2007-05-01 University Of Rochester Method of treating a patient with a neurodegenerative disease using ultrasound
US6303362B1 (en) 1998-11-19 2001-10-16 The Board Of Trustees Of The Leland Stanford Junior University Adenoviral vector and methods for making and using the same
US6790657B1 (en) 1999-01-07 2004-09-14 The United States Of America As Represented By The Department Of Health And Human Services Lentivirus vector system
US6224566B1 (en) 1999-05-04 2001-05-01 Cardiodyne, Inc. Method and devices for creating a trap for confining therapeutic drugs and/or genes in the myocardium
US6161045A (en) 1999-06-01 2000-12-12 Neuropace, Inc. Method for determining stimulation parameters for the treatment of epileptic seizures
US7655423B2 (en) 1999-06-14 2010-02-02 Henry Ford Health System Nitric oxide donors for inducing neurogenesis
US6662039B2 (en) * 1999-06-18 2003-12-09 The Trustees Of Columbia University In The City Of New York Optical probing of neuronal connections with fluorescent indicators
US20040034882A1 (en) * 1999-07-15 2004-02-19 Vale Wylie W. Corticotropin releasing factor receptor 2 deficient mice and uses thereof
US7674463B1 (en) 1999-07-15 2010-03-09 Research Development Foundation Method of inhibiting angiogenesis by administration of a corticotropin releasing factor receptor 2 agonist
EP1207788A4 (en) 1999-07-19 2009-12-09 St Jude Medical Atrial Fibrill DEVICE AND METHOD FOR THE ABLATION OF TISSUE
ES2152900B1 (es) 1999-07-23 2001-08-16 Palleja Xavier Estivill Ratones transgenicos y modelo de sobreexpresion del gen ntrk3 (trkc) basado en los mismos para el estudio y monitorizacion de tratamientos de la ansiedad, depresion y enfermedades psiquiatricas relacionadas.
WO2001011612A1 (en) 1999-08-06 2001-02-15 Mitsubishi Chemical Corporation Tray for conveying magnetic head for magnetic disk
GB9923558D0 (en) 1999-10-05 1999-12-08 Oxford Biomedica Ltd Producer cell
GB9928248D0 (en) 1999-12-01 2000-01-26 Gill Steven S An implantable guide tube for neurosurgery
EP1247093B1 (en) 2000-01-14 2005-03-23 MIGENIX Corp. Screening assays using intramitochondrial calcium
US6595934B1 (en) 2000-01-19 2003-07-22 Medtronic Xomed, Inc. Methods of skin rejuvenation using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US7706882B2 (en) 2000-01-19 2010-04-27 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area
DE60143564D1 (de) 2000-02-18 2011-01-13 Univ R Veränderte rekombinasen zur modifizierung des genoms
US6473639B1 (en) 2000-03-02 2002-10-29 Neuropace, Inc. Neurological event detection procedure using processed display channel based algorithms and devices incorporating these procedures
WO2001083729A2 (en) * 2000-05-01 2001-11-08 Novartis Ag Vectors for ocular transduction and use thereof for genetic therapy
US6599281B1 (en) * 2000-05-03 2003-07-29 Aspect Medical Systems, Inc. System and method for adaptive drug delivery
US6551346B2 (en) * 2000-05-17 2003-04-22 Kent Crossley Method and apparatus to prevent infections
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
US7201898B2 (en) 2000-06-01 2007-04-10 The University Of North Carolina At Chapel Hill Methods and compounds for controlled release of recombinant parvovirus vectors
US7067626B2 (en) * 2000-07-05 2006-06-27 Pharmacia & Upjohn Company Human ion channel proteins
US6686193B2 (en) 2000-07-10 2004-02-03 Vertex Pharmaceuticals, Inc. High throughput method and system for screening candidate compounds for activity against target ion channels
WO2002013906A1 (en) 2000-08-16 2002-02-21 Vanderbilt University Methods and devices for optical stimulation of neural tissues
US6567690B2 (en) * 2000-10-16 2003-05-20 Cole Giller Method and apparatus for probe localization in brain matter
US6536440B1 (en) 2000-10-17 2003-03-25 Sony Corporation Method and system for generating sensory data onto the human neural cortex
US6584357B1 (en) 2000-10-17 2003-06-24 Sony Corporation Method and system for forming an acoustic signal from neural timing difference data
US7350522B2 (en) 2000-10-17 2008-04-01 Sony Corporation Scanning method for applying ultrasonic acoustic data to the human neural cortex
US6631283B2 (en) 2000-11-15 2003-10-07 Virginia Tech Intellectual Properties, Inc. B/B-like fragment targeting for the purposes of photodynamic therapy and medical imaging
US6506154B1 (en) 2000-11-28 2003-01-14 Insightec-Txsonics, Ltd. Systems and methods for controlling a phased array focused ultrasound system
SE525540C2 (sv) 2000-11-30 2005-03-08 Datainnovation I Lund Ab System och förfarande för automatisk provtagning från ett provobjekt
US20070196838A1 (en) 2000-12-08 2007-08-23 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US6489115B2 (en) 2000-12-21 2002-12-03 The Board Of Regents Of The University Of Nebraska Genetic assays for trinucleotide repeat mutations in eukaryotic cells
US6615080B1 (en) * 2001-03-29 2003-09-02 John Duncan Unsworth Neuromuscular electrical stimulation of the foot muscles for prevention of deep vein thrombosis and pulmonary embolism
US7047078B2 (en) 2001-03-30 2006-05-16 Case Western Reserve University Methods for stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses
AU2002303283A1 (en) 2001-04-04 2002-10-21 Irm Llc Methods for treating drug addiction
US7107996B2 (en) * 2001-04-10 2006-09-19 Ganz Robert A Apparatus and method for treating atherosclerotic vascular disease through light sterilization
US6961045B2 (en) 2001-06-16 2005-11-01 Che-Chih Tsao Pattern projection techniques for volumetric 3D displays and 2D displays
US6810285B2 (en) 2001-06-28 2004-10-26 Neuropace, Inc. Seizure sensing and detection using an implantable device
IL159242A0 (en) 2001-07-06 2004-06-01 Senomyx Inc Expression of functional human olfactory cyclic nucleotide gated (cng) channel in recombinant host cells and use thereof in cell based assays to identify smell modulators
ATE360680T1 (de) 2001-08-23 2007-05-15 Univ California Universelles, durch licht einschaltbares genpromotorsystem
US6974448B2 (en) 2001-08-30 2005-12-13 Medtronic, Inc. Method for convection enhanced delivery catheter to treat brain and other tumors
US7904176B2 (en) * 2006-09-07 2011-03-08 Bio Control Medical (B.C.M.) Ltd. Techniques for reducing pain associated with nerve stimulation
WO2003020103A2 (en) 2001-09-04 2003-03-13 Amit Technology Science & Medicine Ltd. Method of and device for therapeutic illumination of internal organs and tissues
US20040054952A1 (en) * 2002-09-13 2004-03-18 Morrow James W. Device verification system and method
EP1496860A1 (en) * 2001-09-28 2005-01-19 Saoirse Corporation Localized non-invasive biological modulation system
US7175596B2 (en) 2001-10-29 2007-02-13 Insightec-Txsonics Ltd System and method for sensing and locating disturbances in an energy path of a focused ultrasound system
US7303578B2 (en) * 2001-11-01 2007-12-04 Photothera, Inc. Device and method for providing phototherapy to the brain
US8308784B2 (en) * 2006-08-24 2012-11-13 Jackson Streeter Low level light therapy for enhancement of neurologic function of a patient affected by Parkinson's disease
US7790845B2 (en) 2001-11-08 2010-09-07 Children's Medical Center Corporation Bacterial ion channel
CA2465337A1 (en) 2001-11-14 2003-05-22 Yamanouchi Pharmaceutical Co., Ltd. Transgenic animal
US20030232430A1 (en) 2001-11-26 2003-12-18 Advanced Cell Technology Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
US20030104512A1 (en) 2001-11-30 2003-06-05 Freeman Alex R. Biosensors for single cell and multi cell analysis
US10695577B2 (en) 2001-12-21 2020-06-30 Photothera, Inc. Device and method for providing phototherapy to the heart
US6873868B2 (en) * 2001-12-31 2005-03-29 Infraredx, Inc. Multi-fiber catheter probe arrangement for tissue analysis or treatment
US6721603B2 (en) * 2002-01-25 2004-04-13 Cyberonics, Inc. Nerve stimulation as a treatment for pain
US6666857B2 (en) 2002-01-29 2003-12-23 Robert F. Smith Integrated wavefront-directed topography-controlled photoablation
US20050107753A1 (en) 2002-02-01 2005-05-19 Ali Rezai Microinfusion device
US7258674B2 (en) 2002-02-20 2007-08-21 Liposonix, Inc. Ultrasonic treatment and imaging of adipose tissue
JP4363843B2 (ja) 2002-03-08 2009-11-11 オリンパス株式会社 カプセル型内視鏡
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
DE10216005A1 (de) 2002-04-11 2003-10-30 Max Planck Gesellschaft Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle
US9592409B2 (en) * 2002-04-30 2017-03-14 The Regents Of The University Of California Methods for modifying electrical currents in neuronal circuits
US7283861B2 (en) 2002-04-30 2007-10-16 Alexander Bystritsky Methods for modifying electrical currents in neuronal circuits
AU2003224374A1 (en) * 2002-05-13 2003-11-11 Koninklijke Philips Electronics N.V. Reduction of susceptibility artifacts in subencoded single-shot magnetic resonance imaging
WO2003101532A2 (en) 2002-06-04 2003-12-11 Cyberkinetics, Inc. Optically-connected implants and related systems and methods of use
EP1519947A1 (de) 2002-06-12 2005-04-06 Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. Pflanzliche proteinpräparate und deren verwendung
US7292890B2 (en) * 2002-06-20 2007-11-06 Advanced Bionics Corporation Vagus nerve stimulation via unidirectional propagation of action potentials
US20050020945A1 (en) 2002-07-02 2005-01-27 Tosaya Carol A. Acoustically-aided cerebrospinal-fluid manipulation for neurodegenerative disease therapy
US20040049134A1 (en) 2002-07-02 2004-03-11 Tosaya Carol A. System and methods for treatment of alzheimer's and other deposition-related disorders of the brain
WO2004021243A2 (de) * 2002-08-09 2004-03-11 Siemens Aktiengesellschaft Verfahren sowie computerprogramm mit programmcode-mitteln und computerprogramm-produkt zur analyse einer wirksamkeit eines pharmazeutischen präparats
US7702395B2 (en) 2002-08-19 2010-04-20 Arizona Board Of Regents, A Body Corporate, Acting For And On Behalf Of Arizona State University Neurostimulator
EP1560915B1 (en) 2002-10-10 2009-03-04 Merck & Co., Inc. Assay methods for state-dependent calcium channel agonists/antagonists
US7355033B2 (en) * 2002-11-18 2008-04-08 Health Research, Inc. Screening for West Nile Virus antiviral therapy
KR20050084317A (ko) 2002-12-16 2005-08-26 제넨테크, 인크. 인간 ｃｄ２０ 및(또는) ｃｄ１６을 발현하는 트랜스제닉마우스
US20040122475A1 (en) * 2002-12-18 2004-06-24 Myrick Andrew J. Electrochemical neuron systems
CA2518407A1 (en) 2003-03-12 2004-09-23 Samaritan Pharmaceuticals, Inc. Animal model simulating neurologic disease
US20040216177A1 (en) 2003-04-25 2004-10-28 Otsuka Pharmaceutical Co., Ltd. Congenic rats containing a mutant GPR10 gene
US7377900B2 (en) 2003-06-02 2008-05-27 Insightec - Image Guided Treatment Ltd. Endo-cavity focused ultrasound transducer
CA2432810A1 (en) 2003-06-19 2004-12-19 Andres M. Lozano Method of treating depression, mood disorders and anxiety disorders by brian infusion
US8367410B2 (en) 2003-06-20 2013-02-05 Massachusetts Institute Of Technology Application of electrical stimulation for functional tissue engineering in vitro and in vivo
US7091500B2 (en) 2003-06-20 2006-08-15 Lucent Technologies Inc. Multi-photon endoscopic imaging system
JP2005034073A (ja) 2003-07-16 2005-02-10 Masamitsu Iino ミオシン軽鎖リン酸化の測定用蛍光性プローブ
US20050153885A1 (en) 2003-10-08 2005-07-14 Yun Anthony J. Treatment of conditions through modulation of the autonomic nervous system
US7548775B2 (en) 2003-10-21 2009-06-16 The Regents Of The University Of Michigan Intracranial neural interface system
US6952097B2 (en) 2003-10-22 2005-10-04 Siemens Aktiengesellschaft Method for slice position planning of tomographic measurements, using statistical images
US20060034943A1 (en) 2003-10-31 2006-02-16 Technology Innovations Llc Process for treating a biological organism
US20080119421A1 (en) * 2003-10-31 2008-05-22 Jack Tuszynski Process for treating a biological organism
EP1701772A4 (en) * 2003-11-21 2012-03-28 Univ Johns Hopkins BIOMOLECOLE PARTITIONING MOTIVES AND USES THEREOF
US20050124897A1 (en) 2003-12-03 2005-06-09 Scimed Life Systems, Inc. Apparatus and methods for delivering acoustic energy to body tissue
US7783349B2 (en) 2006-04-10 2010-08-24 Cardiac Pacemakers, Inc. System and method for closed-loop neural stimulation
CN1236305C (zh) 2004-02-03 2006-01-11 复旦大学 生物光敏蛋白－纳米半导体复合光电极的制备方法
US7662114B2 (en) 2004-03-02 2010-02-16 Focus Surgery, Inc. Ultrasound phased arrays
US20050215764A1 (en) 2004-03-24 2005-09-29 Tuszynski Jack A Biological polymer with differently charged portions
ITMI20040598A1 (it) 2004-03-26 2004-06-26 Carlotta Giorgi Metodo per la rilevazione di parametri intracellulari con sonde proteiche luminescenti per lo screening di molecole in grado di alterare detti parametri
US8512219B2 (en) 2004-04-19 2013-08-20 The Invention Science Fund I, Llc Bioelectromagnetic interface system
US7313442B2 (en) 2004-04-30 2007-12-25 Advanced Neuromodulation Systems, Inc. Method of treating mood disorders and/or anxiety disorders by brain stimulation
US7670838B2 (en) 2004-05-24 2010-03-02 The Board Of Trustees Of The Leland Stanford Junior University Coupling of excitation and neurogenesis in neural stem/progenitor cells
US20050279354A1 (en) 2004-06-21 2005-12-22 Harvey Deutsch Structures and Methods for the Joint Delivery of Fluids and Light
US20060057614A1 (en) * 2004-08-04 2006-03-16 Nathaniel Heintz Tethering neuropeptides and toxins for modulation of ion channels and receptors
US7699780B2 (en) 2004-08-11 2010-04-20 Insightec—Image-Guided Treatment Ltd. Focused ultrasound system with adaptive anatomical aperture shaping
US8409099B2 (en) 2004-08-26 2013-04-02 Insightec Ltd. Focused ultrasound system for surrounding a body tissue mass and treatment method
US8821559B2 (en) * 2004-08-27 2014-09-02 Codman & Shurtleff, Inc. Light-based implants for treating Alzheimer's disease
US8239029B2 (en) 2004-10-21 2012-08-07 Advanced Neuromodulation Systems, Inc. Stimulation of the amygdalohippocampal complex to treat neurological conditions
US7544171B2 (en) 2004-10-22 2009-06-09 General Patent Llc Methods for promoting nerve regeneration and neuronal growth and elongation
US7833257B2 (en) * 2004-11-12 2010-11-16 Northwestern University Apparatus and methods for optical stimulation of the auditory nerve
JP2008520280A (ja) 2004-11-15 2008-06-19 デチャームス，クリストファー 光を使用した神経組織の刺激の適用
US20060129126A1 (en) 2004-11-19 2006-06-15 Kaplitt Michael G Infusion device and method for infusing material into the brain of a patient
US8109981B2 (en) 2005-01-25 2012-02-07 Valam Corporation Optical therapies and devices
US7686839B2 (en) * 2005-01-26 2010-03-30 Lumitex, Inc. Phototherapy treatment devices for applying area lighting to a wound
US7553284B2 (en) 2005-02-02 2009-06-30 Vaitekunas Jeffrey J Focused ultrasound for pain reduction
US9034650B2 (en) * 2005-02-02 2015-05-19 Intrexon Corporation Site-specific serine recombinases and methods of their use
JP2006217866A (ja) 2005-02-10 2006-08-24 Tohoku Univ 光感受性を新たに賦与した神経細胞
US7548780B2 (en) * 2005-02-22 2009-06-16 Cardiac Pacemakers, Inc. Cell therapy and neural stimulation for cardiac repair
US7288108B2 (en) 2005-03-14 2007-10-30 Codman & Shurtleff, Inc. Red light implant for treating Parkinson's disease
US20070059775A1 (en) 2005-03-29 2007-03-15 The Trustees Of Columbia University In The City Of New York Synthesis and conjugation of iron oxide nanoparticles to antibodies for targeting specific cells using fluorescence and MR imaging techniques
CA2602835A1 (en) 2005-03-31 2006-10-05 Esther Mayer Probe device, system and method for photobiomodulation of tissue lining a body cavity
JP2006295350A (ja) 2005-04-07 2006-10-26 Sony Corp 撮像装置及び撮像結果の処理方法
US9445211B2 (en) 2005-04-11 2016-09-13 St. Jude Medical, Atrial Fibrillation Division, Inc. Methods for manufacturing high intensity ultrasound transducers
GB0508254D0 (en) 2005-04-23 2005-06-01 Smith & Nephew Ultrasound device
US7640057B2 (en) 2005-04-25 2009-12-29 Cardiac Pacemakers, Inc. Methods of providing neural markers for sensed autonomic nervous system activity
US8066908B2 (en) 2005-04-26 2011-11-29 Uvic Industry Partnerships Inc. Production of light from sol-gel derived thin films made with lanthanide doped nanoparticles, and preparation thereof
PL1879623T3 (pl) * 2005-05-02 2013-03-29 Genzyme Corp Terapia genowa zaburzeń rdzenia kręgowego
CN1879906A (zh) 2005-06-15 2006-12-20 郑云峰 中枢神经系统磁刺激装置及其使用方法
US20070027443A1 (en) 2005-06-29 2007-02-01 Ondine International, Ltd. Hand piece for the delivery of light and system employing the hand piece
US10052497B2 (en) * 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
EP1919497B1 (en) 2005-07-22 2020-02-12 The Board of Trustees of the Leland Stanford Junior University Light-activated cation channel and uses thereof
US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
US9238150B2 (en) * 2005-07-22 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Optical tissue interface method and apparatus for stimulating cells
US8926959B2 (en) * 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US7736382B2 (en) 2005-09-09 2010-06-15 Lockheed Martin Corporation Apparatus for optical stimulation of nerves and other animal tissue
US8852184B2 (en) * 2005-09-15 2014-10-07 Cannuflow, Inc. Arthroscopic surgical temperature control system
US20080077200A1 (en) * 2006-09-21 2008-03-27 Aculight Corporation Apparatus and method for stimulation of nerves and automated control of surgical instruments
US8058509B2 (en) 2005-12-21 2011-11-15 Pioneer Hi-Bred International, Inc. Methods and compositions for in planta production of inverted repeats
US7610100B2 (en) * 2005-12-30 2009-10-27 Boston Scientific Neuromodulation Corporation Methods and systems for treating osteoarthritis
US20070191906A1 (en) * 2006-02-13 2007-08-16 Anand Iyer Method and apparatus for selective nerve stimulation
US20070219600A1 (en) * 2006-03-17 2007-09-20 Michael Gertner Devices and methods for targeted nasal phototherapy
US20070282404A1 (en) 2006-04-10 2007-12-06 University Of Rochester Side-firing linear optic array for interstitial optical therapy and monitoring using compact helical geometry
US20070253995A1 (en) 2006-04-28 2007-11-01 Medtronic, Inc. Drug Delivery Methods and Devices for Treating Stress Urinary Incontinence
US8057464B2 (en) 2006-05-03 2011-11-15 Light Sciences Oncology, Inc. Light transmission system for photoreactive therapy
EP2019588A4 (en) 2006-05-04 2010-11-24 Univ Wayne State RESTORATION OF VISUAL RESPONSES BY IN VIVO ADMINISTRATION OF NUCLEIC ACIDS OF RHODOPSIN
US20080176076A1 (en) 2006-05-11 2008-07-24 University Of Victoria Innovation And Development Corporation Functionalized lanthanide rich nanoparticles and use thereof
US20080262411A1 (en) * 2006-06-02 2008-10-23 Dobak John D Dynamic nerve stimulation in combination with other eating disorder treatment modalities
JP5250549B2 (ja) * 2006-06-19 2013-07-31 ハイランド インストゥルメンツ， インコーポレイテッド 生体組織の刺激のための器具および方法
US7795632B2 (en) 2006-06-26 2010-09-14 Osram Sylvania Inc. Light emitting diode with direct view optic
US9284363B2 (en) 2006-07-26 2016-03-15 Case Western Reserve University System and method for controlling G-protein coupled receptor pathways
US20080027505A1 (en) * 2006-07-26 2008-01-31 G&L Consulting, Llc System and method for treatment of headaches
SG139588A1 (en) 2006-07-28 2008-02-29 St Microelectronics Asia Addressable led architecure
US7848797B2 (en) * 2006-08-17 2010-12-07 Neurometrix, Inc. Motor unit number estimation (MUNE) for the assessment of neuromuscular function
US7558145B2 (en) * 2006-08-31 2009-07-07 Infineon Technologies Ag Word line control for improving read and write margins
US7521590B2 (en) * 2006-09-01 2009-04-21 Korea Institute Of Science And Technology Phospholipase C β1 (PLCβ1) knockout mice as a model system for testing schizophrenia drugs
US10420948B2 (en) * 2006-10-30 2019-09-24 Medtronic, Inc. Implantable medical device with variable data retransmission characteristics based upon data type
US20100021982A1 (en) 2006-12-06 2010-01-28 Stefan Herlitze Light-sensitive constructs for inducing cell death and cell signaling
EE200600039A (et) 2006-12-12 2008-10-15 Tartu Ülikool Transgeenne loommudel patoloogilise ärevuse modelleerimiseks, meetod patoloogilisest ärevusest p?hjustatud haiguste v?i seisundite ravimiseks sobilike ühendite tuvastamiseks ja meetod Wfs1 valgu kasutamiseks sihtmärgina patoloogilise ärevuse vastase
WO2008086470A1 (en) 2007-01-10 2008-07-17 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US7883536B1 (en) 2007-01-19 2011-02-08 Lockheed Martin Corporation Hybrid optical-electrical probes
WO2008101128A1 (en) 2007-02-14 2008-08-21 The Board Of Trustees Of The Leland Stanford Junior University System, method and applications involving identification of biological circuits such as neurological characteristics
WO2008106694A2 (en) 2007-03-01 2008-09-04 The Board Of Trustees Of The Leland Stanford Junior University Systems, methods and compositions for optical stimulation of target cells
US8282559B2 (en) 2007-03-09 2012-10-09 Philip Chidi Njemanze Method for inducing and monitoring long-term potentiation and long-term depression using transcranial doppler ultrasound device in head-down bed rest
US8139339B2 (en) 2007-03-16 2012-03-20 Old Dominion University Research Foundation Modulation of neuromuscular functions with ultrashort electrical pulses
US20080287821A1 (en) * 2007-03-30 2008-11-20 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational user-health testing
CN101288768A (zh) 2007-04-20 2008-10-22 中央研究院 用于治疗渐进神经退化症的医药组合物
EP2142082A4 (en) * 2007-05-01 2015-10-28 Neurofocus Inc STORAGE SYSTEM FOR NEUROINFORMATIK
US20110165681A1 (en) 2009-02-26 2011-07-07 Massachusetts Institute Of Technology Light-Activated Proton Pumps and Applications Thereof
US8097422B2 (en) * 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
US9138596B2 (en) 2007-08-22 2015-09-22 Cardiac Pacemakers, Inc. Optical depolarization of cardiac tissue
US8090955B2 (en) * 2007-10-17 2012-01-03 Micron Technology, Inc. Boot block features in synchronous serial interface NAND
US10434327B2 (en) 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
US10035027B2 (en) * 2007-10-31 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Device and method for ultrasonic neuromodulation via stereotactic frame based technique
US20090157145A1 (en) * 2007-11-26 2009-06-18 Lawrence Cauller Transfer Coil Architecture
EP2222372A2 (en) 2007-12-06 2010-09-01 Technion Research & Development Foundation Ltd. Method and system for optical stimulation of neurons
US8883719B2 (en) * 2008-01-16 2014-11-11 University Of Connecticut Bacteriorhodopsin protein variants and methods of use for long term data storage
US20090254134A1 (en) 2008-02-04 2009-10-08 Medtrode Inc. Hybrid ultrasound/electrode device for neural stimulation and recording
JP5544659B2 (ja) 2008-03-24 2014-07-09 国立大学法人東北大学 改変された光受容体チャネル型ロドプシンタンパク質
EP2268311A4 (en) * 2008-04-04 2014-08-27 Immunolight Llc NON-INVASIVE SYSTEMS AND IN SITU PHOTOBIOMODULATION METHODS
MY169771A (en) 2008-04-23 2019-05-15 Univ Leland Stanford Junior Systems, methods and compositions for optical stimulation of target cells
EP2910637A1 (en) 2008-05-20 2015-08-26 University of Florida Research Foundation, Inc. Vectors for delivery of light-sensitive proteins and methods of use
WO2009148946A2 (en) * 2008-05-29 2009-12-10 The Board Of Trustees Of The Leland Stanford Junior University Cell line, system and method for optical control of secondary messengers
US8636653B2 (en) 2008-06-09 2014-01-28 Capso Vision, Inc. In vivo camera with multiple sources to illuminate tissue at different distances
JP2011525130A (ja) 2008-06-17 2011-09-15 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ 光伝送素子を用いた標的細胞の光刺激のための方法、システム、および装置
EP2303405A4 (en) 2008-06-17 2017-12-27 The Board of Trustees of the Leland Stanford Junior University Apparatus and methods for controlling cellular development
WO2010006049A1 (en) 2008-07-08 2010-01-14 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
US9846313B2 (en) 2008-09-25 2017-12-19 The Trustees Of Columbia University In The City Of New York Devices, apparatus and method for providing photostimulation and imaging of structures
NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
WO2010061686A1 (ja) 2008-11-26 2010-06-03 シャープ株式会社 液晶表示装置、液晶表示装置の駆動方法、テレビジョン受像機
WO2010111358A2 (en) * 2009-03-24 2010-09-30 Spinal Modulation, Inc. Pain management with stimulation subthreshold to parasthesia
KR101081360B1 (ko) 2009-03-25 2011-11-08 한국과학기술연구원 어레이형 광 자극 장치
TWI511756B (zh) 2009-04-21 2015-12-11 伊穆諾萊特公司 用以修飾介導生物活性或與生物活性有關之標靶結構之醫藥組合物或套組
WO2011005978A2 (en) 2009-07-08 2011-01-13 Duke University Methods of manipulating cell signaling
JP5322067B2 (ja) 2009-08-10 2013-10-23 国立大学法人東北大学 発現効率が改善された光受容チャネルロドプシン
US20110112463A1 (en) 2009-11-12 2011-05-12 Jerry Silver Compositions and methods for treating a neuronal injury or neuronal disorders
US20110125078A1 (en) * 2009-11-25 2011-05-26 Medtronic, Inc. Optical stimulation therapy
AU2011220367B2 (en) 2010-02-26 2016-05-12 Cornell University Retina prosthesis
WO2011116238A2 (en) 2010-03-17 2011-09-22 The Board Of Trustees Of The Leland Stanford Junior University. Light-sensitive ion-passing molecules
WO2011127088A2 (en) 2010-04-05 2011-10-13 Eos Neuroscience, Inc. Methods and compositions for decreasing chronic pain
US10051240B2 (en) 2010-06-14 2018-08-14 Howard Hughes Medical Institute Structured plane illumination microscopy
CA2838330C (en) 2010-08-23 2021-01-26 President And Fellows Of Harvard College Optogenetic probes for measuring membrane potential
PL2614079T3 (pl) 2010-09-08 2016-01-29 Max Planck Gesellschaft Zmutowana kanałowa rodopsyna 2
WO2012061741A2 (en) 2010-11-05 2012-05-10 The Board Of Trustees Of The Leland Stanford Junior University. Control and characterization of psychotic states
CN106106368A (zh) 2010-11-05 2016-11-16 斯坦福大学托管董事会 光控cns功能障碍
WO2012061679A2 (en) 2010-11-05 2012-05-10 The Board Of Trustees Of The Leland Stanford Junior University Light-activated chimeric opsins and methods of using the same
AU2011323235B2 (en) 2010-11-05 2015-10-29 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of reward-related behaviors
CN106422081B (zh) 2010-11-05 2019-06-21 斯坦福大学托管董事会 用于光遗传学方法的光的上转换
CN106376525A (zh) 2010-11-05 2017-02-08 斯坦福大学托管董事会 记忆功能的控制和表征
ES2684307T3 (es) 2010-11-05 2018-10-02 The Board Of Trustees Of The Leland Stanford Junior University Proteínas estabilizadas de tipo opsina de función escalonada y métodos de uso de las mismas
US8957028B2 (en) 2010-11-13 2015-02-17 Massachusetts Institute Of Technology Red-shifted opsin molecules and uses thereof
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
WO2012106407A2 (en) 2011-02-01 2012-08-09 The University Of Vermont And State Agricultural College Diagnostic and therapeutic methods and products related to anxiety disorders
JP5746885B2 (ja) 2011-03-14 2015-07-08 株式会社ニフコ 可動体のアシスト装置及びハウジング
US20120253261A1 (en) 2011-03-29 2012-10-04 Medtronic, Inc. Systems and methods for optogenetic modulation of cells within a patient
CA2839938A1 (en) 2011-06-28 2013-01-03 University Of Rochester Photoactivatable receptors and their uses
WO2013016389A1 (en) 2011-07-25 2013-01-31 Neuronexus Technologies, Inc. Opto-electrical device and method for artifact reduction
EP3385992B1 (en) 2011-07-27 2024-09-04 The Board of Trustees of the University of Illinois Nanopore sensors for biomolecular characterization
US8759492B2 (en) 2011-08-17 2014-06-24 The Regents Of The University Of California Engineered red-shifted channelrhodopsin variants
CA2859364C (en) 2011-12-16 2019-05-07 The Board Of Trustees Of The Leland Stanford Junior University Opsin polypeptides and methods of use thereof
EP3205374B1 (en) 2012-02-21 2019-03-27 The Board of Trustees of The Leland Stanford Junior University Compositions for treating neurogenic disorders of the pelvic floor
WO2013126762A1 (en) 2012-02-23 2013-08-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health Multi-focal structured illumination microscopy systems and methods
AU2013235517B2 (en) 2012-03-20 2018-11-08 The Board Of Trustees Of The Leland Stanford Junior University Non-human animal models of depression and methods of use thereof
JP6580487B2 (ja) 2012-11-21 2019-09-25 サーキット セラピューティクス， インコーポレイテッド 光遺伝学的治療のためのシステムおよび方法
WO2014117079A1 (en) 2013-01-25 2014-07-31 The Trustees Of Columbia University In The City Of New York Depth of field 3d imaging slm microscope
JP6594854B2 (ja) 2013-03-15 2019-10-23 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 行動状態の光遺伝学的制御方法
US9636380B2 (en) 2013-03-15 2017-05-02 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of inputs to the ventral tegmental area
AU2014260101B2 (en) 2013-04-29 2018-07-26 Humboldt-Universitat Zu Berlin Devices, systems and methods for optogenetic modulation of action potentials in target cells
EP3033427A4 (en) 2013-08-14 2017-05-31 The Board Of Trustees Of The University Of the Leland Stanford Junior University Compositions and methods for controlling pain
US20150112411A1 (en) 2013-10-18 2015-04-23 Varaya Photoceuticals, Llc High powered light emitting diode photobiology compositions, methods and systems
EP3122761B1 (en) 2014-03-28 2019-03-06 The Board of Trustees of The Leland Stanford Junior University Engineered light-activated anion channel proteins and methods of use thereof
US20170182191A1 (en) 2014-07-29 2017-06-29 Circuit Therapeutics, Inc. System and method for optogenetic therapy
KR101898185B1 (ko) 2014-11-11 2018-09-12 광동 오포 모바일 텔레커뮤니케이션즈 코포레이션 리미티드 전원 어댑터, 단말기 및 충전 시스템
CN107206106A (zh) 2014-12-04 2017-09-26 斯坦福大学托管董事会 2型多巴胺受体特异性启动子和其使用方法
WO2017087542A1 (en) 2015-11-18 2017-05-26 The Board Of Trustees Of The Leland Stanford Junior University Method and systems for measuring neural activity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050119315A1 (en) * 1999-03-31 2005-06-02 Cardiome Pharma Corp. Ion channel modulating activity II
US20030040080A1 (en) * 2001-08-16 2003-02-27 Gero Miesenbock Bio-synthetic photostimulators and methods of use
US20030232339A1 (en) * 2002-04-01 2003-12-18 Youmin Shu Human TRPCC cation channel and uses
WO2003102156A2 (en) * 2002-05-31 2003-12-11 Sloan-Kettering Institute For Cancer Research Heterologous stimulus-gated ion channels and methods of using same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6011068965; Ｐｒｏｃ．　Ｎａｔｌ．　Ａｃａｄ．　Ｓｃｉ．　ＵＳＡ，　１００［２４］（２００３）　ｐ．１３９４０-１３９４５ *
JPN7011004763; Ｉｎｖｅｓｔ．　Ｏｐｈｔｈａｌｍｏｌ．　Ｖｉｓ．　Ｓｃｉ．，　４６［５］（Ｍａｙ　２００５）　Ｅ-Ａｂｓｔｒａｃｔ　４６３１ *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2013038666A1 (ja) * 2011-09-12 2015-03-23 国立大学法人東北大学 ラット脳内光誘発けいれんモデル
JP2016509487A (ja) * 2012-11-21 2016-03-31 サーキット セラピューティクス， インコーポレイテッド 光遺伝学的治療のためのシステムおよび方法
JP2022110036A (ja) * 2015-12-09 2022-07-28 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 機能的脳回路解析の方法
JP7324897B2 (ja) 2015-12-09 2023-08-10 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 機能的脳回路解析の方法
JP2019047763A (ja) * 2017-09-12 2019-03-28 国立大学法人 名古屋工業大学 ロドプシンホスホジエステラーゼ
JP2024509088A (ja) * 2021-02-24 2024-02-29 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 脳への聴覚入力を回復または増強するための事前形成された神経組織

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