JP2009084295A5 - - Google Patents
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- Publication number
- JP2009084295A5 JP2009084295A5 JP2008306269A JP2008306269A JP2009084295A5 JP 2009084295 A5 JP2009084295 A5 JP 2009084295A5 JP 2008306269 A JP2008306269 A JP 2008306269A JP 2008306269 A JP2008306269 A JP 2008306269A JP 2009084295 A5 JP2009084295 A5 JP 2009084295A5
- Authority
- JP
- Japan
- Prior art keywords
- tripeptide
- pharmaceutical composition
- tyr
- leu
- val
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- MSFITIBEMPWCBD-ULQDDVLXSA-N Leu-Val-Tyr Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 MSFITIBEMPWCBD-ULQDDVLXSA-N 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 239000002220 antihypertensive agent Substances 0.000 claims 4
- 229940030600 antihypertensive agent Drugs 0.000 claims 4
- 230000035622 drinking Effects 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 230000036772 blood pressure Effects 0.000 claims 3
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 claims 2
- 239000005541 ACE inhibitor Substances 0.000 claims 2
- 101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 claims 2
- 101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 claims 2
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 claims 2
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 claims 2
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 1
- 230000004531 blood pressure lowering effect Effects 0.000 claims 1
- 235000013402 health food Nutrition 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008306269A JP4369986B2 (ja) | 2003-03-18 | 2008-12-01 | アンジオテンシン変換酵素阻害ペプチド |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003074488 | 2003-03-18 | ||
| JP2008306269A JP4369986B2 (ja) | 2003-03-18 | 2008-12-01 | アンジオテンシン変換酵素阻害ペプチド |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006507670A Division JP4283848B2 (ja) | 2003-03-18 | 2004-03-17 | アンジオテンシン変換酵素阻害ペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009084295A JP2009084295A (ja) | 2009-04-23 |
| JP2009084295A5 true JP2009084295A5 (OSRAM) | 2009-06-04 |
| JP4369986B2 JP4369986B2 (ja) | 2009-11-25 |
Family
ID=33027809
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006507670A Expired - Lifetime JP4283848B2 (ja) | 2003-03-18 | 2004-03-17 | アンジオテンシン変換酵素阻害ペプチド |
| JP2008306269A Expired - Lifetime JP4369986B2 (ja) | 2003-03-18 | 2008-12-01 | アンジオテンシン変換酵素阻害ペプチド |
| JP2008306249A Expired - Lifetime JP4369985B2 (ja) | 2003-03-18 | 2008-12-01 | アンジオテンシン変換酵素阻害ペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006507670A Expired - Lifetime JP4283848B2 (ja) | 2003-03-18 | 2004-03-17 | アンジオテンシン変換酵素阻害ペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008306249A Expired - Lifetime JP4369985B2 (ja) | 2003-03-18 | 2008-12-01 | アンジオテンシン変換酵素阻害ペプチド |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7833985B2 (OSRAM) |
| EP (3) | EP1605969B1 (OSRAM) |
| JP (3) | JP4283848B2 (OSRAM) |
| KR (3) | KR101077801B1 (OSRAM) |
| CN (1) | CN100402089C (OSRAM) |
| AU (3) | AU2004222435B2 (OSRAM) |
| CA (3) | CA2743313C (OSRAM) |
| CY (1) | CY1114072T1 (OSRAM) |
| DK (1) | DK1605969T3 (OSRAM) |
| ES (3) | ES2400308T3 (OSRAM) |
| PL (3) | PL1938832T3 (OSRAM) |
| PT (1) | PT1605969E (OSRAM) |
| TW (3) | TWI411441B (OSRAM) |
| WO (1) | WO2004082709A1 (OSRAM) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4046708B2 (ja) * | 2004-06-04 | 2008-02-13 | 明治製菓株式会社 | 3−アルケニルセフェム化合物の製造方法 |
| JP2006219420A (ja) * | 2005-02-10 | 2006-08-24 | Nagase Chemtex Corp | 抗高血圧剤 |
| US20090143311A1 (en) * | 2005-04-28 | 2009-06-04 | Luppo Edens | Compositions comprising tripeptides inhibiting ace |
| ZA200708791B (en) * | 2005-04-28 | 2009-08-26 | Unilever Plc | Peptides having an ace inhibiting effect |
| WO2006114192A1 (en) * | 2005-04-28 | 2006-11-02 | Unilever N.V. | Peptides having an ace inhibiting effect |
| ZA200708795B (en) * | 2005-04-28 | 2009-08-26 | Unilever Plc | Peptides having a healthy benefit and compositions comprising them |
| ATE453399T1 (de) * | 2005-05-24 | 2010-01-15 | Chr Hansen As | Isolierte dipeptide mit ace-inhibitionseffekt |
| JP4994093B2 (ja) * | 2006-04-13 | 2012-08-08 | ロート製薬株式会社 | 育毛剤 |
| CN100456948C (zh) * | 2006-06-30 | 2009-02-04 | 北京三友汇智生物技术有限公司 | 一种燕麦肽及其提取方法 |
| KR100787949B1 (ko) * | 2007-08-29 | 2007-12-24 | 한양대학교 산학협력단 | 대두 발효 조성물의 제조방법 및 이 조성물로부터 유래된펩타이드 |
| JP2009073765A (ja) * | 2007-09-20 | 2009-04-09 | Nitsukoku Seifun Kk | アンジオテンシン変換酵素(ace)阻害剤組成物及びその製造方法 |
| JP2010163400A (ja) * | 2009-01-19 | 2010-07-29 | Kikkoman Corp | 新規アンジオテンシン変換酵素阻害ペプチド |
| CN101618207B (zh) * | 2009-06-17 | 2011-08-03 | 中国科学院大连化学物理研究所 | 多肽在制备ace抑制剂及降血压药物中的应用 |
| CN102665749B (zh) * | 2009-07-13 | 2014-09-17 | 不二制油株式会社 | 口服抗炎剂和口服抗炎肽 |
| CN101696233B (zh) * | 2009-10-29 | 2012-02-01 | 吉林大学 | 蛋清蛋白血管紧张素转化酶抑制肽及其制备 |
| JP5654290B2 (ja) * | 2010-08-27 | 2015-01-14 | ユニチカ株式会社 | アンジオテンシン変換酵素阻害ペプチド及びその製造方法。 |
| CN102399261B (zh) * | 2010-09-07 | 2014-06-25 | 任发政 | 具有血管紧张素转化酶c-端选择性抑制活性的三肽及其应用和组合物 |
| CN102475884B (zh) * | 2010-11-29 | 2013-08-14 | 中国科学院大连化学物理研究所 | 四个多肽在制备ace抑制剂及降血压药物中的应用 |
| CN102276690B (zh) * | 2011-08-05 | 2013-03-20 | 成都中医药大学 | 降血压功能性多肽及其用途 |
| JP6296722B2 (ja) * | 2012-07-31 | 2018-03-20 | サンスター株式会社 | 米糠酵素処理組成物 |
| KR101481416B1 (ko) * | 2012-10-17 | 2015-01-13 | 건국대학교 산학협력단 | 안지오텐신 전환 효소 저해 활성을 갖는 펩타이드 |
| JP2014141462A (ja) * | 2012-12-27 | 2014-08-07 | Raffinee International Co Ltd | ペプチド、並びに、アンジオテンシン変換酵素阻害剤、抗高血圧剤、及び飲食品 |
| US9820504B2 (en) | 2013-03-08 | 2017-11-21 | Axiom Foods, Inc. | Rice protein supplement and methods of use thereof |
| CN108271917A (zh) | 2013-03-08 | 2018-07-13 | 艾斯姆食品公司 | 大米蛋白补充剂 |
| CN103172698B (zh) * | 2013-04-10 | 2015-02-18 | 华东理工大学 | 降血压多肽 |
| CN103242430B (zh) * | 2013-05-31 | 2014-10-08 | 南京中医药大学 | 血管紧张素转化酶抑制肽及其制备方法和应用 |
| CN103290086B (zh) * | 2013-06-25 | 2015-01-14 | 广州合诚实业有限公司 | 具有ace抑制活性的绿豆蛋白肽及其制备方法与应用 |
| CN104558110B (zh) * | 2013-10-21 | 2018-06-08 | 中国科学院大连化学物理研究所 | 具有ace抑制活性的多肽及其在降血压药物中的应用 |
| CN104558109B (zh) * | 2013-10-21 | 2018-06-08 | 中国科学院大连化学物理研究所 | 源于油菜花粉的具有ace抑制活性的多肽化合物及应用 |
| CN104447948B (zh) * | 2014-11-25 | 2017-12-08 | 肽能九号生物科技有限公司 | 一种从荠菜中分离获得的降血压多肽 |
| US10676505B2 (en) | 2016-06-16 | 2020-06-09 | Sunstar Inc. | Tripeptides having angiotensin converting enzyme inhibitory activity and uses thereof |
| CN110028549B (zh) * | 2016-07-07 | 2022-08-05 | 华东理工大学 | 降血压肽和降血压蛋白质及其应用 |
| CN110868870A (zh) | 2017-05-12 | 2020-03-06 | 艾斯姆食品公司 | 大米产物及制备它们的系统和方法 |
| WO2019006954A1 (zh) * | 2017-07-07 | 2019-01-10 | 广州世优生物科技有限公司 | 含硫二肽在制备降血压药物或保健品中的应用 |
| CN110498833B (zh) * | 2019-08-30 | 2021-01-15 | 华南理工大学 | 一种具有ace抑制作用的三肽及其应用 |
| CA3160647A1 (en) * | 2019-12-09 | 2021-06-17 | Societe Des Produits Nestle S.A. | Beverage paste |
| JP7391738B2 (ja) * | 2020-03-19 | 2023-12-05 | Kisco株式会社 | ペプチド、及び苦味付与剤 |
| CN111548387B (zh) * | 2020-03-31 | 2020-12-18 | 华南农业大学 | 一种具有降血压功效的寡肽及其制备方法与应用 |
| CN111471086B (zh) * | 2020-04-16 | 2023-01-24 | 河南省农业科学院 | 芝麻多肽及其制备方法和应用 |
| CN111825754B (zh) * | 2020-07-16 | 2022-02-11 | 河南省农业科学院 | 一种从芝麻蛋白中获得的具有降血压与降血糖活性的多肽 |
| WO2022168413A1 (ja) * | 2021-02-04 | 2022-08-11 | ユーハ味覚糖株式会社 | デプレスタチン含有組成物の製造方法 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52148631A (en) | 1976-06-01 | 1977-12-10 | Kitazato Daigaku Yakurigakubu | Enzym obstruction agent |
| DE3112394A1 (de) * | 1980-07-22 | 1982-07-08 | Eltreva AG, 4147 Aesch | "einrichtung zur luftregulierung einer energiefassade" |
| JPS6023085B2 (ja) | 1981-12-23 | 1985-06-05 | 工業技術院長 | アンジオテンシン転換酵素阻害剤 |
| US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
| US5156840A (en) * | 1982-03-09 | 1992-10-20 | Cytogen Corporation | Amine-containing porphyrin derivatives |
| JPS6023086B2 (ja) | 1982-09-04 | 1985-06-05 | 工業技術院長 | アンジオテンシン転換酵素阻害剤 |
| JPS6023087A (ja) | 1983-07-20 | 1985-02-05 | Canon Inc | リボンカセツト |
| JPS6023086A (ja) | 1983-07-20 | 1985-02-05 | Canon Inc | リボンカセツト |
| DE3485587D1 (de) * | 1983-08-16 | 1992-04-23 | Univ Georgia Res Found | Herstellung von aminocyclopropancarbonsaeuren und von peptiden. |
| JPS6136226A (ja) | 1984-07-28 | 1986-02-20 | Agency Of Ind Science & Technol | アンジオテンシン転換酵素阻害剤 |
| JPS6136227A (ja) | 1984-07-28 | 1986-02-20 | Agency Of Ind Science & Technol | アンジオテンシン転換酵素阻害剤 |
| JPS6286741A (ja) | 1985-10-11 | 1987-04-21 | Mitsubishi Electric Corp | パタ−ンの位置合わせずれ量評価方法 |
| JP2805032B2 (ja) | 1988-07-27 | 1998-09-30 | 工業技術院長 | アンジオテンシン変換酵素阻害剤 |
| JP2873318B2 (ja) | 1989-03-14 | 1999-03-24 | 工業技術院長 | 血圧降下剤 |
| JPH0311097A (ja) | 1989-06-07 | 1991-01-18 | Senmi Ekisu Kk | 新規ペプチド |
| JPH0623086B2 (ja) | 1989-07-19 | 1994-03-30 | 花王株式会社 | 洗浄剤組成物 |
| JP3103363B2 (ja) * | 1990-03-30 | 2000-10-30 | 昭和産業株式会社 | 新規トリペプチド及び血圧降下剤 |
| DE69124274T2 (de) * | 1990-02-27 | 1997-08-14 | Agency Ind Science Techn | Oligopeptide, sie enthaltende pharmazeutische und Futterzusammensetzung und Benützung von Oligopeptiden |
| JP3073762B2 (ja) | 1990-10-03 | 2000-08-07 | 日本合成化学工業株式会社 | アンギオテンシン変換酵素阻害剤含有組成物の製造方法 |
| JPH06136227A (ja) | 1992-10-22 | 1994-05-17 | Nippon Steel Chem Co Ltd | 熱可塑性樹脂組成物 |
| JP3357097B2 (ja) | 1992-10-27 | 2002-12-16 | 株式会社クラレ | 耐衝撃性メタクリル樹脂組成物 |
| JP2820868B2 (ja) | 1993-08-27 | 1998-11-05 | 日清食品株式会社 | アンジオテンシン変換酵素阻害蛋白分解物 |
| ES2170105T3 (es) * | 1993-10-04 | 2002-08-01 | Pasteur Institut | Compuestos que modifican la transmision serotoninergica; aplicaciones diagnosticas y terapeuticas. |
| US5558993A (en) * | 1994-06-17 | 1996-09-24 | The Regents Of The University Of California | Cloned Borrelia burgdorferi virulence protein |
| JP3135812B2 (ja) | 1995-03-01 | 2001-02-19 | 日清食品株式会社 | アンジオテンシン変換酵素阻害ペプチドおよびその製造方法 |
| JP3567012B2 (ja) | 1995-03-28 | 2004-09-15 | 雪印乳業株式会社 | 新規ペプチド及びその利用 |
| JP4727770B2 (ja) * | 1997-09-26 | 2011-07-20 | カルピス株式会社 | 尿中カテコールアミン低下、尿中ノルアドレナリン低下、尿中ドーパミン低下及びFischer比低下の少なくとも1つの軽減剤 |
| JP3028411B2 (ja) * | 1997-09-26 | 2000-04-04 | カルピス株式会社 | トリペプチド高生産性ラクトバチルス・ヘルベチカス乳酸菌 |
| CN1377276A (zh) * | 1999-08-09 | 2002-10-30 | 特里帕普股份公司 | 含有三肽的药用组合物 |
| JP3592593B2 (ja) * | 1999-10-15 | 2004-11-24 | 日本合成化学工業株式会社 | アンギオテンシン変換酵素阻害剤 |
| FI113741B (fi) * | 1999-11-01 | 2004-06-15 | Valio Oy | Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi |
| WO2001068115A1 (en) * | 2000-03-13 | 2001-09-20 | Monsanto Technology Llc | Process for producing peptide sequences possessing anti-hypertension activity |
| WO2001081368A2 (en) * | 2000-04-21 | 2001-11-01 | Monsanto Technology Llc | Blood-pressure reducing polypeptides containing vpp derived from microorganisms |
| WO2002062973A2 (en) * | 2001-02-07 | 2002-08-15 | Novozymes A/S | Lipase variants |
| JP4144696B2 (ja) | 2002-11-07 | 2008-09-03 | タイヨーエレック株式会社 | 遊技機 |
-
2004
- 2004-03-15 TW TW100111621A patent/TWI411441B/zh not_active IP Right Cessation
- 2004-03-15 TW TW097129374A patent/TWI344371B/zh not_active IP Right Cessation
- 2004-03-15 TW TW093106867A patent/TWI328457B/zh not_active IP Right Cessation
- 2004-03-17 WO PCT/JP2004/003588 patent/WO2004082709A1/en not_active Ceased
- 2004-03-17 JP JP2006507670A patent/JP4283848B2/ja not_active Expired - Lifetime
- 2004-03-17 CN CNB2004800112694A patent/CN100402089C/zh not_active Expired - Lifetime
- 2004-03-17 KR KR1020117000078A patent/KR101077801B1/ko not_active Expired - Fee Related
- 2004-03-17 CA CA2743313A patent/CA2743313C/en not_active Expired - Fee Related
- 2004-03-17 CA CA2526891A patent/CA2526891C/en not_active Expired - Fee Related
- 2004-03-17 US US10/549,176 patent/US7833985B2/en not_active Expired - Fee Related
- 2004-03-17 EP EP04721339A patent/EP1605969B1/en not_active Expired - Lifetime
- 2004-03-17 EP EP09172830A patent/EP2145630B1/en not_active Expired - Lifetime
- 2004-03-17 AU AU2004222435A patent/AU2004222435B2/en not_active Ceased
- 2004-03-17 PL PL08153738T patent/PL1938832T3/pl unknown
- 2004-03-17 PL PL09172830T patent/PL2145630T3/pl unknown
- 2004-03-17 ES ES08153738T patent/ES2400308T3/es not_active Expired - Lifetime
- 2004-03-17 CA CA2743539A patent/CA2743539C/en not_active Expired - Fee Related
- 2004-03-17 PL PL04721339T patent/PL1605969T3/pl unknown
- 2004-03-17 KR KR1020117000079A patent/KR101078628B1/ko not_active Expired - Fee Related
- 2004-03-17 PT PT47213392T patent/PT1605969E/pt unknown
- 2004-03-17 DK DK04721339.2T patent/DK1605969T3/da active
- 2004-03-17 KR KR1020057017447A patent/KR101119449B1/ko not_active Expired - Fee Related
- 2004-03-17 EP EP08153738A patent/EP1938832B1/en not_active Expired - Lifetime
- 2004-03-17 ES ES09172830T patent/ES2398788T3/es not_active Expired - Lifetime
- 2004-03-17 ES ES04721339T patent/ES2400561T3/es not_active Expired - Lifetime
-
2008
- 2008-12-01 JP JP2008306269A patent/JP4369986B2/ja not_active Expired - Lifetime
- 2008-12-01 JP JP2008306249A patent/JP4369985B2/ja not_active Expired - Lifetime
-
2009
- 2009-06-12 US US12/483,676 patent/US7943578B2/en not_active Expired - Fee Related
- 2009-11-12 AU AU2009236033A patent/AU2009236033B2/en not_active Ceased
- 2009-11-12 AU AU2009236034A patent/AU2009236034B2/en not_active Ceased
-
2013
- 2013-04-26 CY CY20131100344T patent/CY1114072T1/el unknown
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