JP2009024028A5 - - Google Patents
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- JP2009024028A5 JP2009024028A5 JP2008245073A JP2008245073A JP2009024028A5 JP 2009024028 A5 JP2009024028 A5 JP 2009024028A5 JP 2008245073 A JP2008245073 A JP 2008245073A JP 2008245073 A JP2008245073 A JP 2008245073A JP 2009024028 A5 JP2009024028 A5 JP 2009024028A5
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- JP
- Japan
- Prior art keywords
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- phe
- arg
- group
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008245073A JP4654284B2 (ja) | 2004-06-25 | 2008-09-25 | メタスチン誘導体およびその用途 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004187671 | 2004-06-25 | ||
| JP2004363311 | 2004-12-15 | ||
| JP2008245073A JP4654284B2 (ja) | 2004-06-25 | 2008-09-25 | メタスチン誘導体およびその用途 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006554374A Division JP4346650B2 (ja) | 2004-06-25 | 2005-06-23 | メタスチン誘導体およびその用途 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009132363A Division JP2009227687A (ja) | 2004-06-25 | 2009-06-01 | メタスチン誘導体およびその用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009024028A JP2009024028A (ja) | 2009-02-05 |
| JP2009024028A5 true JP2009024028A5 (enExample) | 2009-03-19 |
| JP4654284B2 JP4654284B2 (ja) | 2011-03-16 |
Family
ID=34971534
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006554374A Expired - Fee Related JP4346650B2 (ja) | 2004-06-25 | 2005-06-23 | メタスチン誘導体およびその用途 |
| JP2008245073A Expired - Fee Related JP4654284B2 (ja) | 2004-06-25 | 2008-09-25 | メタスチン誘導体およびその用途 |
| JP2009132363A Pending JP2009227687A (ja) | 2004-06-25 | 2009-06-01 | メタスチン誘導体およびその用途 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006554374A Expired - Fee Related JP4346650B2 (ja) | 2004-06-25 | 2005-06-23 | メタスチン誘導体およびその用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009132363A Pending JP2009227687A (ja) | 2004-06-25 | 2009-06-01 | メタスチン誘導体およびその用途 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7625869B2 (enExample) |
| EP (2) | EP1758932A2 (enExample) |
| JP (3) | JP4346650B2 (enExample) |
| CN (2) | CN101845091A (enExample) |
| AR (1) | AR049938A1 (enExample) |
| AU (1) | AU2005257484A1 (enExample) |
| BR (1) | BRPI0512397A (enExample) |
| CA (1) | CA2571420A1 (enExample) |
| CL (1) | CL2008003730A1 (enExample) |
| CR (1) | CR8828A (enExample) |
| IL (1) | IL179640A0 (enExample) |
| MA (1) | MA28903B1 (enExample) |
| MX (1) | MXPA06014206A (enExample) |
| NO (1) | NO20065957L (enExample) |
| NZ (1) | NZ552029A (enExample) |
| PE (2) | PE20060371A1 (enExample) |
| RU (1) | RU2006145886A (enExample) |
| SG (1) | SG153865A1 (enExample) |
| TW (1) | TW200607816A (enExample) |
| WO (1) | WO2006001499A2 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1494732T1 (sl) | 2002-03-20 | 2008-08-31 | Mannking Corp | Inhalacijski aparat |
| CN1761680A (zh) | 2002-12-26 | 2006-04-19 | 武田药品工业株式会社 | 肿瘤迁移抑制素衍生物及其用途 |
| WO2004080479A1 (ja) | 2003-03-12 | 2004-09-23 | Takeda Pharmaceutical Company Limited | 性腺機能改善剤 |
| EP1737573A2 (en) | 2004-04-08 | 2007-01-03 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| PE20060371A1 (es) | 2004-06-25 | 2006-06-15 | Takeda Pharmaceutical | Derivados de metastina en el tratamiento del cancer |
| KR101273120B1 (ko) | 2004-08-20 | 2013-06-13 | 맨카인드 코포레이션 | 다이케토피페라진 합성의 촉매 작용 |
| BR122019022692B1 (pt) | 2004-08-23 | 2023-01-10 | Mannkind Corporation | Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo |
| KR101486829B1 (ko) | 2005-09-14 | 2015-01-29 | 맨카인드 코포레이션 | 결정질 미립자 표면에 대한 활성제의 친화력의 증가를 기반으로 하는 약물 제제의 방법 |
| US20090093615A1 (en) * | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| AR058584A1 (es) * | 2005-12-22 | 2008-02-13 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos |
| US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| EP1986679B1 (en) | 2006-02-22 | 2017-10-25 | MannKind Corporation | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
| WO2007125619A1 (ja) * | 2006-04-26 | 2007-11-08 | Kyoto University | Gpr54アゴニスト活性を有する新規化合物 |
| ITMI20061607A1 (it) * | 2006-08-09 | 2008-02-10 | Maria Vincenza Carriero | Peptidi con attivita farmacologica |
| UA94774C2 (en) * | 2006-10-25 | 2011-06-10 | Такеда Фармасьютикал Компани Лимитед | Metastin derivatives and use thereof |
| JO3048B1 (ar) * | 2006-10-25 | 2016-09-05 | Takeda Pharmaceuticals Co | مشتقات متاستين واستخدامها |
| EP2277900A4 (en) * | 2008-04-24 | 2011-08-03 | Takeda Pharmaceutical | METASTINE DERIVATIVE AND ITS USE |
| US8592379B2 (en) | 2008-04-30 | 2013-11-26 | Kyoto University | Metastin derivative and use thereof |
| TWI677355B (zh) | 2008-06-13 | 2019-11-21 | 美商曼凱公司 | 用於藥物傳輸之乾粉吸入器及系統 |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| ES2421385T3 (es) | 2008-06-20 | 2013-09-02 | Mannkind Corp | Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación |
| SMT201700131T1 (it) | 2008-07-30 | 2017-05-08 | Takeda Pharmaceuticals Co | Derivato di metastina e suo uso |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| EP2379053A1 (en) * | 2008-12-29 | 2011-10-26 | Takeda Pharmaceutical Company Limited | Prophylactic/therapeutic agent for cancer |
| US8716228B2 (en) | 2009-05-27 | 2014-05-06 | Yeda Research And Development Co. Ltd. | GPR54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities |
| NZ600157A (en) | 2009-12-22 | 2013-07-26 | Takeda Pharmaceutical | Sustained-release formulation comprising metastin derivative |
| MX359281B (es) | 2010-06-21 | 2018-09-21 | Mannkind Corp | Sistema y metodos para suministrar un farmaco en polvo seco. |
| CA2806734A1 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| CA2806670A1 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| US8925726B2 (en) | 2011-04-01 | 2015-01-06 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| EP2755690B1 (en) | 2011-08-04 | 2020-04-01 | Merck Sharp & Dohme B.V. | Kisspeptide-pentasaccharide conjugates |
| CA2852536A1 (en) | 2011-10-24 | 2013-05-02 | Mannkind Corporation | Methods and compositions for treating pain |
| WO2013136338A1 (en) | 2012-03-14 | 2013-09-19 | Yeda Research And Development Co. Ltd At The Weizmann Institute Of Science | Modified kisspeptin peptides and uses thereof |
| CA2878457C (en) | 2012-07-12 | 2021-01-19 | Mannkind Corporation | Dry powder drug delivery systems and methods |
| HK1217117A1 (zh) | 2012-12-20 | 2016-12-23 | 生物马特里卡公司 | 用於使pcr试剂稳定化的制剂和方法 |
| JP6143270B2 (ja) * | 2013-01-31 | 2017-06-07 | 学校法人東京薬科大学 | マイオスタチン阻害ペプチド |
| EP3021834A1 (en) | 2013-07-18 | 2016-05-25 | MannKind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
| US10220069B2 (en) * | 2014-01-22 | 2019-03-05 | The Johns Hopkins University | Compositions and methods for treating diabetes |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| WO2015191632A1 (en) | 2014-06-10 | 2015-12-17 | Biomatrica, Inc. | Stabilization of thrombocytes at ambient temperatures |
| WO2017100212A1 (en) | 2015-12-08 | 2017-06-15 | Biomatrica, Inc. | Reduction of erythrocyte sedimentation rate |
| TWI778979B (zh) | 2016-09-30 | 2022-10-01 | 瑞士商麥歐文科學有限公司 | 治療女性不孕症之方法 |
| TWI810193B (zh) | 2017-07-05 | 2023-08-01 | 大陸商尚華醫藥科技(江西)有限公司 | 一種Kiss1肽類化合物、其應用及含其的組合物 |
| CN108752233B (zh) * | 2018-07-18 | 2020-10-16 | 河北师范大学 | 小分子凝胶因子、凝胶材料及制备方法和应用 |
| US20230159450A1 (en) * | 2020-05-08 | 2023-05-25 | The Feinstein Institutes For Medical Research | Dimers for use in synthesis of peptidomimetics |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1524747A (en) * | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
| FR2488253A1 (fr) * | 1980-08-08 | 1982-02-12 | Roques Bernard | Nouveaux peptides et leur application en therapeutique |
| IL74827A (en) | 1984-05-21 | 1989-06-30 | Salk Inst For Biological Studi | Peptides active as gnrh antagonists and pharmaceutical compositions containing them |
| MX9100717A (es) * | 1990-08-24 | 1992-04-01 | Syntex Inc | Antagonistas de la bradiquinina |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| JPH09169735A (ja) | 1995-10-19 | 1997-06-30 | Takeda Chem Ind Ltd | キノリン誘導体、その製造法および用途 |
| EP0876349B1 (en) | 1995-10-19 | 2002-09-11 | Takeda Chemical Industries, Ltd. | Quinoline derivatives as gnrh antagonists |
| EP0910579A1 (en) | 1996-04-19 | 1999-04-28 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| CA2283299A1 (en) | 1997-03-07 | 1998-09-11 | Human Genome Sciences, Inc. | 186 human secreted proteins |
| JP4486187B2 (ja) | 1998-10-27 | 2010-06-23 | 武田薬品工業株式会社 | 新規g蛋白質共役型レセプター蛋白質、そのdnaおよびそのリガンド |
| US6528054B1 (en) | 1998-12-28 | 2003-03-04 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
| CN1359297A (zh) | 1999-06-28 | 2002-07-17 | 巴斯福股份公司 | 预防肿瘤生长的方法 |
| US6638906B1 (en) | 1999-12-13 | 2003-10-28 | Nobex Corporation | Amphiphilic polymers and polypeptide conjugates comprising same |
| CA2394404A1 (en) | 1999-12-17 | 2001-06-21 | Takeda Chemical Industries, Ltd. | Process for producing kiss-1 peptide |
| JP2001231581A (ja) * | 1999-12-17 | 2001-08-28 | Takeda Chem Ind Ltd | KiSS−1ペプチドの製造法 |
| CA2404233A1 (en) | 2000-03-29 | 2001-10-04 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| AU2001244609A1 (en) * | 2000-03-30 | 2001-10-15 | Takeda Chemical Industries Ltd. | Novel protein, dna thereof and process for producing the same |
| US7834141B1 (en) | 2000-03-31 | 2010-11-16 | Theresa Siler-Khodr | Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy |
| RU2311920C2 (ru) | 2000-09-20 | 2007-12-10 | Корикса Корпорейшн | Композиции и способы для лечения и диагностики рака легких |
| JP2003026601A (ja) | 2000-11-29 | 2003-01-29 | Takeda Chem Ind Ltd | 医薬組成物およびその製造法 |
| JP2002320496A (ja) | 2001-02-26 | 2002-11-05 | Takeda Chem Ind Ltd | 新規マウス型KiSS−1レセプタータンパク質およびそのDNA |
| WO2002085399A1 (fr) | 2001-04-20 | 2002-10-31 | Takeda Chemical Industries, Ltd. | Preparations contenant un peptide |
| JP2003070488A (ja) | 2001-05-17 | 2003-03-11 | Takeda Chem Ind Ltd | ペプチドの製造法 |
| WO2003027149A1 (fr) | 2001-09-19 | 2003-04-03 | Takeda Chemical Industries, Ltd. | Anticorps et utilisation de ce dernier |
| CA2472423A1 (en) | 2002-01-11 | 2003-07-24 | Takeda Chemical Industries, Ltd. | Process for producing kiss-1 peptide |
| JP2003300906A (ja) | 2002-04-12 | 2003-10-21 | Daiichi Fine Chemical Co Ltd | がん転移抑制因子の安定化 |
| CA2501556A1 (en) | 2002-10-09 | 2004-04-29 | Kyowa Hakko Kogyo Co., Ltd. | Remedy for hormone-dependent cancer |
| EP1554382B1 (en) | 2002-10-25 | 2009-04-22 | Takeda Pharmaceutical Company Limited | Gpr54 knock-out mammals and screening methods using them |
| JP4804714B2 (ja) | 2002-12-26 | 2011-11-02 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
| CN1761680A (zh) | 2002-12-26 | 2006-04-19 | 武田药品工业株式会社 | 肿瘤迁移抑制素衍生物及其用途 |
| US6800611B2 (en) | 2003-01-06 | 2004-10-05 | Takeda Chemical Industries, Ltd. | Metastin derivatives and their use |
| KR100595364B1 (ko) | 2003-02-20 | 2006-07-03 | 재단법인 목암생명공학연구소 | Lk8 단백질을 유효성분으로 포함하는 항암제 |
| WO2004080479A1 (ja) | 2003-03-12 | 2004-09-23 | Takeda Pharmaceutical Company Limited | 性腺機能改善剤 |
| EP1464652A1 (en) | 2003-04-02 | 2004-10-06 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | GPR54 receptor agonist and antagonist useful for the treatment of gonadotropin related diseases |
| US20050002935A1 (en) | 2003-04-17 | 2005-01-06 | Vincent Ling | Use of B7-H3 as an immunoregulatory agent |
| AU2004234399A1 (en) | 2003-04-28 | 2004-11-11 | Wyeth | Methods utilising G-protein coupled receptor 54 |
| WO2004101747A2 (en) | 2003-05-07 | 2004-11-25 | The General Hospital Corporation | Identification and use of gpr54 and its ligands for reproductive disorders and contraception |
| US20070155803A1 (en) | 2003-05-30 | 2007-07-05 | Prozymex A/S | Protease inhibitors |
| EP1688498B1 (en) | 2003-11-03 | 2011-03-09 | Beijing Sunbio Biotech Co., Ltd. | A recombinant protein with cancer suppression action, its encoding gene and use |
| RU2333221C2 (ru) | 2003-11-03 | 2008-09-10 | Бейцзин Санбио Байотек Ко., Лтд. | Рекомбинантный белок, обладающий противораковым действием, кодирующий его ген и его применение |
| WO2005095973A2 (en) | 2004-03-25 | 2005-10-13 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 54 (gpr54) |
| JP2007533748A (ja) | 2004-04-23 | 2007-11-22 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | 不妊症の処置のためのgpcr54リガンドの使用 |
| PE20060371A1 (es) | 2004-06-25 | 2006-06-15 | Takeda Pharmaceutical | Derivados de metastina en el tratamiento del cancer |
| WO2007084211A2 (en) | 2005-11-11 | 2007-07-26 | The General Hospital Corporation | Use of gpr54 ligands for treatment of reproductive disorders, proliferative disorders, and for contraception |
| AR058584A1 (es) | 2005-12-22 | 2008-02-13 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos |
| US20090093615A1 (en) | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US20090099334A1 (en) | 2005-12-22 | 2009-04-16 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| ATE516300T1 (de) | 2006-03-20 | 2011-07-15 | Merck Sharp & Dohme | Neuromedin-u-rezeptoragonisten und ihre verwendung |
| US20100215637A1 (en) | 2006-03-28 | 2010-08-26 | Biopharmica Ltd | Agent for the Treatment of Hormone-Dependent Disorders and Uses Thereof |
| JO3048B1 (ar) | 2006-10-25 | 2016-09-05 | Takeda Pharmaceuticals Co | مشتقات متاستين واستخدامها |
| EP2206721A1 (en) | 2007-10-05 | 2010-07-14 | Takeda Pharmaceutical Company Limited | Neuromedin u derivative |
| EP2277900A4 (en) | 2008-04-24 | 2011-08-03 | Takeda Pharmaceutical | METASTINE DERIVATIVE AND ITS USE |
| EP2340047A1 (en) | 2008-09-19 | 2011-07-06 | Nektar Therapeutics | Polymer conjugates of kiss1 peptides |
-
2005
- 2005-06-23 PE PE2005000728A patent/PE20060371A1/es not_active Application Discontinuation
- 2005-06-23 US US11/630,698 patent/US7625869B2/en not_active Expired - Fee Related
- 2005-06-23 PE PE2009000637A patent/PE20091567A1/es not_active Application Discontinuation
- 2005-06-23 NZ NZ552029A patent/NZ552029A/en not_active IP Right Cessation
- 2005-06-23 WO PCT/JP2005/012021 patent/WO2006001499A2/en not_active Ceased
- 2005-06-23 CN CN200910225195A patent/CN101845091A/zh active Pending
- 2005-06-23 TW TW094120917A patent/TW200607816A/zh unknown
- 2005-06-23 AR ARP050102591A patent/AR049938A1/es unknown
- 2005-06-23 CN CN200910225194A patent/CN101863971A/zh active Pending
- 2005-06-23 EP EP05755666A patent/EP1758932A2/en not_active Withdrawn
- 2005-06-23 JP JP2006554374A patent/JP4346650B2/ja not_active Expired - Fee Related
- 2005-06-23 BR BRPI0512397-6A patent/BRPI0512397A/pt not_active IP Right Cessation
- 2005-06-23 RU RU2006145886/04A patent/RU2006145886A/ru not_active Application Discontinuation
- 2005-06-23 EP EP09075257.7A patent/EP2113513B1/en not_active Expired - Lifetime
- 2005-06-23 SG SG200904360-5A patent/SG153865A1/en unknown
- 2005-06-23 AU AU2005257484A patent/AU2005257484A1/en not_active Abandoned
- 2005-06-23 MX MXPA06014206A patent/MXPA06014206A/es unknown
- 2005-06-23 CA CA002571420A patent/CA2571420A1/en not_active Abandoned
-
2006
- 2006-11-27 IL IL179640A patent/IL179640A0/en unknown
- 2006-12-21 NO NO20065957A patent/NO20065957L/no not_active Application Discontinuation
- 2006-12-22 CR CR8828A patent/CR8828A/es not_active Application Discontinuation
- 2006-12-28 MA MA29567A patent/MA28903B1/fr unknown
-
2008
- 2008-09-25 JP JP2008245073A patent/JP4654284B2/ja not_active Expired - Fee Related
- 2008-10-01 US US12/286,671 patent/US8778871B2/en active Active
- 2008-12-15 CL CL2008003730A patent/CL2008003730A1/es unknown
-
2009
- 2009-06-01 JP JP2009132363A patent/JP2009227687A/ja active Pending
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