JP2010507565A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010507565A5 JP2010507565A5 JP2009518179A JP2009518179A JP2010507565A5 JP 2010507565 A5 JP2010507565 A5 JP 2010507565A5 JP 2009518179 A JP2009518179 A JP 2009518179A JP 2009518179 A JP2009518179 A JP 2009518179A JP 2010507565 A5 JP2010507565 A5 JP 2010507565A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- atom
- substituted
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006290536 | 2006-10-25 | ||
| JP2007021387 | 2007-01-31 | ||
| JP2007221911 | 2007-08-28 | ||
| PCT/JP2007/071169 WO2008050897A1 (en) | 2006-10-25 | 2007-10-24 | Metastin derivatives and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013004011A Division JP5686825B2 (ja) | 2006-10-25 | 2013-01-11 | メタスチン誘導体およびその用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010507565A JP2010507565A (ja) | 2010-03-11 |
| JP2010507565A5 true JP2010507565A5 (enExample) | 2010-12-09 |
Family
ID=38925530
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009518179A Pending JP2010507565A (ja) | 2006-10-25 | 2007-10-24 | メタスチン誘導体およびその用途 |
| JP2013004011A Expired - Fee Related JP5686825B2 (ja) | 2006-10-25 | 2013-01-11 | メタスチン誘導体およびその用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013004011A Expired - Fee Related JP5686825B2 (ja) | 2006-10-25 | 2013-01-11 | メタスチン誘導体およびその用途 |
Country Status (33)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003292696A1 (en) | 2002-12-26 | 2004-08-10 | Takeda Pharmaceutical Company Limited | Metastin derivative and use thereof |
| MXPA06014206A (es) | 2004-06-25 | 2007-02-14 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos. |
| TWI386417B (zh) | 2005-12-22 | 2013-02-21 | Takeda Pharmaceutical | 轉移抑素衍生物及其用途 |
| US20090093615A1 (en) * | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US20090099334A1 (en) * | 2005-12-22 | 2009-04-16 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US8183212B2 (en) * | 2006-04-26 | 2012-05-22 | Kyoto University | Compound having GPR54 agonistic activity |
| TWI404726B (zh) | 2006-10-25 | 2013-08-11 | Takeda Pharmaceutical | 腫瘤轉移抑制素衍生物及其用途 |
| US8110639B2 (en) * | 2006-11-17 | 2012-02-07 | Solvay Advanced Polymers, L.L.C. | Transparent and flame retardant polysulfone compositions |
| EP2277900A4 (en) * | 2008-04-24 | 2011-08-03 | Takeda Pharmaceutical | METASTINE DERIVATIVE AND ITS USE |
| EP2275433B1 (en) * | 2008-04-30 | 2017-06-07 | Kyoto University | Metastin derivative and use thereof |
| US20110212890A1 (en) * | 2008-07-30 | 2011-09-01 | Takeda Pharmaceutical Company Limited | Metastin derivative and use thereof |
| US8716228B2 (en) | 2009-05-27 | 2014-05-06 | Yeda Research And Development Co. Ltd. | GPR54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities |
| BR112012032544A2 (pt) * | 2010-06-25 | 2016-10-11 | Takeda Pharmaceutical | formulação de liberação prolongada, uso de um composto, e, método para produzir a formulação de liberação prolongada. |
| US9127038B2 (en) | 2011-08-04 | 2015-09-08 | Merck Sharp & Dohme Corp. | Kisspeptide-pentasaccharide conjugates |
| JP6612742B2 (ja) * | 2013-06-12 | 2019-11-27 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 関節症の処置のためのヒドロキシエチレン誘導体 |
| US10220069B2 (en) * | 2014-01-22 | 2019-03-05 | The Johns Hopkins University | Compositions and methods for treating diabetes |
| JP6253146B2 (ja) * | 2014-02-04 | 2017-12-27 | 国立大学法人山口大学 | 新規なペプチド誘導体及びこれを含有する医薬 |
| WO2016125172A1 (en) * | 2015-02-08 | 2016-08-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Peptides for the treatment of malignant proliferative diseases |
| CN109206481B (zh) | 2017-07-05 | 2023-08-18 | 尚华医药科技(江西)有限公司 | 一种肽类化合物、其应用及含其的组合物 |
| TWI795462B (zh) * | 2017-11-17 | 2023-03-11 | 日商鹽野義製藥股份有限公司 | 光安定性及溶出性優異的醫藥製劑 |
| EP4132559A4 (en) * | 2020-04-08 | 2024-06-12 | Rutgers, the State University of New Jersey | MODIFIED KISSPEPTIN RECEPTOR AGONISTS FOR FATTY LIVER STEATOSIS |
| WO2025217074A1 (en) * | 2024-04-08 | 2025-10-16 | Radionetics Oncology, Inc. | Kisspeptin receptor (kiss1r) targeted therapeutics and uses thereof |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL74827A (en) | 1984-05-21 | 1989-06-30 | Salk Inst For Biological Studi | Peptides active as gnrh antagonists and pharmaceutical compositions containing them |
| MX9100717A (es) | 1990-08-24 | 1992-04-01 | Syntex Inc | Antagonistas de la bradiquinina |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| JPH09169735A (ja) | 1995-10-19 | 1997-06-30 | Takeda Chem Ind Ltd | キノリン誘導体、その製造法および用途 |
| AU7333496A (en) | 1995-10-19 | 1997-05-07 | Takeda Chemical Industries Ltd. | Quinoline derivatives as gnrh antagonists |
| AU2382097A (en) | 1996-04-19 | 1997-11-12 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| CA2283299A1 (en) | 1997-03-07 | 1998-09-11 | Human Genome Sciences, Inc. | 186 human secreted proteins |
| JP4486187B2 (ja) * | 1998-10-27 | 2010-06-23 | 武田薬品工業株式会社 | 新規ｇ蛋白質共役型レセプター蛋白質、そのｄｎａおよびそのリガンド |
| US6528054B1 (en) | 1998-12-28 | 2003-03-04 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
| HK1047045A1 (zh) | 1999-06-28 | 2003-02-07 | Abbott Gmbh & Co. Kg | 預防腫瘤生長的方法 |
| US6638906B1 (en) | 1999-12-13 | 2003-10-28 | Nobex Corporation | Amphiphilic polymers and polypeptide conjugates comprising same |
| WO2001044469A1 (fr) | 1999-12-17 | 2001-06-21 | Takeda Chemical Industries, Ltd. | PROCEDE DE PRODUCTION DE PEPTIDE KiSS-1 |
| HUP0500345A2 (hu) | 2000-03-29 | 2005-07-28 | Corixa Corporation | Készítmények és alkalmazások tüdőrák kezelésére és diagnosztizálására |
| CA2404257A1 (en) | 2000-03-30 | 2001-10-11 | Takeda Chemical Industries, Ltd. | Novel protein, dna thereof and process for producing the same |
| US7834141B1 (en) | 2000-03-31 | 2010-11-16 | Theresa Siler-Khodr | Non-mammalian GnRH analogs and uses thereof in tumor cell growth regulation and cancer therapy |
| RU2311920C2 (ru) | 2000-09-20 | 2007-12-10 | Корикса Корпорейшн | Композиции и способы для лечения и диагностики рака легких |
| JP2003026601A (ja) | 2000-11-29 | 2003-01-29 | Takeda Chem Ind Ltd | 医薬組成物およびその製造法 |
| JP2002320496A (ja) | 2001-02-26 | 2002-11-05 | Takeda Chem Ind Ltd | 新規マウス型ＫｉＳＳ−１レセプタータンパク質およびそのＤＮＡ |
| WO2002085399A1 (fr) | 2001-04-20 | 2002-10-31 | Takeda Chemical Industries, Ltd. | Preparations contenant un peptide |
| US20040185525A1 (en) | 2001-05-17 | 2004-09-23 | Osamu Nishimura | Process for producing peptide |
| ATE360034T1 (de) * | 2001-09-19 | 2007-05-15 | Takeda Pharmaceutical | Antikörper gegen metastin und dessen verwendung zur diagnose von schwangerschaft |
| EP1466976A4 (en) | 2002-01-11 | 2005-11-09 | Takeda Pharmaceutical | PROCESS FOR PREPARING KISS-1 PEPTIDES |
| JP2003300906A (ja) | 2002-04-12 | 2003-10-21 | Daiichi Fine Chemical Co Ltd | がん転移抑制因子の安定化 |
| US20060035875A1 (en) * | 2002-10-09 | 2006-02-16 | Yukimasa Shiotsu | Remedy for hormone-dependent cancer |
| CA2503164A1 (en) | 2002-10-25 | 2004-05-06 | Paradigm Therapeutics Limited | Gpr54 knock-out mammals and screening methods using them |
| JP4804714B2 (ja) | 2002-12-26 | 2011-11-02 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
| AU2003292696A1 (en) * | 2002-12-26 | 2004-08-10 | Takeda Pharmaceutical Company Limited | Metastin derivative and use thereof |
| US6800611B2 (en) * | 2003-01-06 | 2004-10-05 | Takeda Chemical Industries, Ltd. | Metastin derivatives and their use |
| KR100595364B1 (ko) | 2003-02-20 | 2006-07-03 | 재단법인 목암생명공학연구소 | Ｌｋ8 단백질을 유효성분으로 포함하는 항암제 |
| EP1604682A4 (en) | 2003-03-12 | 2009-06-24 | Takeda Chemical Industries Ltd | AGENTS IMPROVING GONADIC FUNCTION |
| EP1464652A1 (en) | 2003-04-02 | 2004-10-06 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | GPR54 receptor agonist and antagonist useful for the treatment of gonadotropin related diseases |
| US20050002935A1 (en) | 2003-04-17 | 2005-01-06 | Vincent Ling | Use of B7-H3 as an immunoregulatory agent |
| CA2523600A1 (en) | 2003-04-28 | 2004-11-11 | Wyeth | Methods utilising g-protein coupled receptor 54 |
| WO2004101747A2 (en) | 2003-05-07 | 2004-11-25 | The General Hospital Corporation | Identification and use of gpr54 and its ligands for reproductive disorders and contraception |
| US20070155803A1 (en) | 2003-05-30 | 2007-07-05 | Prozymex A/S | Protease inhibitors |
| JP4688678B2 (ja) | 2003-11-03 | 2011-05-25 | 北京沙東生物技術有限公司 | 抗癌作用を有する組換えタンパク質、それをコードする遺伝子、及びそれらの使用 |
| WO2005095973A2 (en) | 2004-03-25 | 2005-10-13 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 54 (gpr54) |
| CA2562676A1 (en) | 2004-04-23 | 2005-12-15 | Applied Research Systems Ars Holding N.V. | Use of gpcr54 ligands for the treatment of infertility |
| MXPA06014206A (es) * | 2004-06-25 | 2007-02-14 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos. |
| WO2007084211A2 (en) | 2005-11-11 | 2007-07-26 | The General Hospital Corporation | Use of gpr54 ligands for treatment of reproductive disorders, proliferative disorders, and for contraception |
| US20090093615A1 (en) * | 2005-12-22 | 2009-04-09 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US20090099334A1 (en) * | 2005-12-22 | 2009-04-16 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| TWI386417B (zh) * | 2005-12-22 | 2013-02-21 | Takeda Pharmaceutical | 轉移抑素衍生物及其用途 |
| US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| JP2009530379A (ja) | 2006-03-20 | 2009-08-27 | メルク エンド カムパニー インコーポレーテッド | ニューロメジンｕ受容体アゴニスト及びその使用 |
| WO2007109857A1 (en) * | 2006-03-28 | 2007-10-04 | Biopharmica Ltd | Agent for the treatment of hormone-dependent disorders and uses thereof |
| TWI404726B (zh) | 2006-10-25 | 2013-08-11 | Takeda Pharmaceutical | 腫瘤轉移抑制素衍生物及其用途 |
| WO2009044918A1 (ja) | 2007-10-05 | 2009-04-09 | Takeda Pharmaceutical Company Limited | ニューロメジンｕ誘導体 |
| EP2277900A4 (en) | 2008-04-24 | 2011-08-03 | Takeda Pharmaceutical | METASTINE DERIVATIVE AND ITS USE |
| EP2340047A1 (en) | 2008-09-19 | 2011-07-06 | Nektar Therapeutics | Polymer conjugates of kiss1 peptides |
-
2007
- 2007-10-23 TW TW096139608A patent/TWI404726B/zh active
- 2007-10-23 JO JOP/2007/0448A patent/JO3048B1/ar active
- 2007-10-24 WO PCT/JP2007/071169 patent/WO2008050897A1/en not_active Ceased
- 2007-10-24 HR HRP20150819TT patent/HRP20150819T1/hr unknown
- 2007-10-24 CL CL200703053A patent/CL2007003053A1/es unknown
- 2007-10-24 AR ARP070104699A patent/AR063367A1/es active IP Right Grant
- 2007-10-24 NZ NZ576375A patent/NZ576375A/en not_active IP Right Cessation
- 2007-10-24 AU AU2007309969A patent/AU2007309969B2/en not_active Ceased
- 2007-10-24 US US11/977,477 patent/US7786083B2/en active Active
- 2007-10-24 ME MEP-2009-130A patent/ME00786B/me unknown
- 2007-10-24 PT PT78309036T patent/PT2081955E/pt unknown
- 2007-10-24 SI SI200731649T patent/SI2081955T1/sl unknown
- 2007-10-24 KR KR1020097010545A patent/KR101424306B1/ko not_active Expired - Fee Related
- 2007-10-24 MY MYPI20091689A patent/MY145975A/en unknown
- 2007-10-24 ES ES07830903.6T patent/ES2539430T3/es active Active
- 2007-10-24 PE PE2007001444A patent/PE20081469A1/es active IP Right Grant
- 2007-10-24 JP JP2009518179A patent/JP2010507565A/ja active Pending
- 2007-10-24 DK DK07830903.6T patent/DK2081955T3/da active
- 2007-10-24 RS RS20150413A patent/RS54083B1/sr unknown
- 2007-10-24 CA CA2667537A patent/CA2667537C/en active Active
- 2007-10-24 US US12/446,142 patent/US8765909B2/en active Active
- 2007-10-24 MX MX2009004148A patent/MX2009004148A/es active IP Right Grant
- 2007-10-24 PL PL07830903T patent/PL2081955T3/pl unknown
- 2007-10-24 EP EP20070830903 patent/EP2081955B1/en active Active
- 2007-10-24 HU HUE07830903A patent/HUE025291T2/en unknown
- 2007-10-24 BR BRPI0717441A patent/BRPI0717441B8/pt not_active IP Right Cessation
- 2007-10-24 GE GEAP200711265A patent/GEP20125568B/en unknown
-
2009
- 2009-04-06 IL IL198046A patent/IL198046A/en active IP Right Grant
- 2009-04-15 TN TNP2009000140A patent/TN2009000140A1/fr unknown
- 2009-04-16 NO NO20091487A patent/NO341584B1/no unknown
- 2009-04-23 EC EC2009009279A patent/ECSP099279A/es unknown
- 2009-05-13 MA MA31868A patent/MA30887B1/fr unknown
- 2009-05-15 CR CR10799A patent/CR10799A/es unknown
-
2013
- 2013-01-11 JP JP2013004011A patent/JP5686825B2/ja not_active Expired - Fee Related
-
2015
- 2015-07-29 CY CY20151100668T patent/CY1116627T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4346650B2 (ja) | メタスチン誘導体およびその用途 | |
| CA2718148C (en) | Oxytocin analogues | |
| CA2774593C (en) | Oxytocin receptor agonists | |
| US5480869A (en) | Anti-inflammatory peptide analogs and treatment to inhibit vascular leakage in injured tissues | |
| US6953779B2 (en) | Melanocortin receptor antagonists and modulations of melanocortin receptor activity | |
| RU2008125063A (ru) | Производные метастина и их применение | |
| JP5307542B2 (ja) | 治療的に活性なα−ＭＳＨアナログ | |
| KR20060014444A (ko) | 멜라노코르틴 수용체 4 (ｍｃ4) 작용제 및 그의 용도 | |
| JP2013075913A (ja) | メタスチン誘導体およびその用途 | |
| JP2010265271A (ja) | ソマトスタチンベクター | |
| US7732412B2 (en) | Methods of treatment using novel LHRH antagonists having improved solubility properties | |
| US20070042950A1 (en) | Antagonistic analogs of gh rh (2003) | |
| EP3539551B1 (en) | Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers | |
| WO2015196944A1 (zh) | GnRH类似物-细胞毒分子缀合物、其制备方法及用途 | |
| JP2949129B2 (ja) | 胃腸運動刺激活性を有するモチリン類似ポリペプチド | |
| US6426330B1 (en) | Satiety inducing composition comprising Neuropeptide Y analogues and methods of inducing satiety and treating a disease or condition associated with it | |
| RU2009119507A (ru) | Производные метастина и их применение | |
| EP1255770A1 (en) | Melanin-concentrating hormone analogs | |
| CA2005420C (en) | Competitive gonadoliberin antagonists | |
| JPH03502336A (ja) | 魚のｃｒｆ | |
| US20030105278A1 (en) | Melanin-concentrating hormone analogs | |
| JP5715104B2 (ja) | 治療的に活性なα−ＭＳＨアナログ | |
| WO2015019376A1 (en) | Synthetic cyclic peptides, agonists and antagonists of urotensin-ii and process for the production thereof | |
| TH71270B (th) | อนุพันธ์เมทาสทินและการใช้ของสารเหล่านั้น | |
| TH95342A (th) | อนุพันธ์เมทาสทินและการใช้ของสารเหล่านั้น |