JP2008543338A5 - - Google Patents

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JP2008543338A5
JP2008543338A5 JP2008518339A JP2008518339A JP2008543338A5 JP 2008543338 A5 JP2008543338 A5 JP 2008543338A5 JP 2008518339 A JP2008518339 A JP 2008518339A JP 2008518339 A JP2008518339 A JP 2008518339A JP 2008543338 A5 JP2008543338 A5 JP 2008543338A5
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bmp
cells
culturing
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culture
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JP2008518339A
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JP2008543338A (ja
JP5560393B2 (ja
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Priority claimed from PCT/US2006/024060 external-priority patent/WO2007002136A2/en
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JP2008518339A 2005-06-22 2006-06-20 心筋細胞系列細胞への霊長類多能性幹細胞の分化 Expired - Fee Related JP5560393B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69314105P 2005-06-22 2005-06-22
US60/693,141 2005-06-22
PCT/US2006/024060 WO2007002136A2 (en) 2005-06-22 2006-06-20 Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells

Related Child Applications (1)

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JP2013135917A Division JP2013215206A (ja) 2005-06-22 2013-06-28 心筋細胞系列細胞への霊長類多能性幹細胞の分化

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JP2008543338A JP2008543338A (ja) 2008-12-04
JP2008543338A5 true JP2008543338A5 (enExample) 2009-04-16
JP5560393B2 JP5560393B2 (ja) 2014-07-23

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JP2008518339A Expired - Fee Related JP5560393B2 (ja) 2005-06-22 2006-06-20 心筋細胞系列細胞への霊長類多能性幹細胞の分化
JP2013135917A Pending JP2013215206A (ja) 2005-06-22 2013-06-28 心筋細胞系列細胞への霊長類多能性幹細胞の分化

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JP2013135917A Pending JP2013215206A (ja) 2005-06-22 2013-06-28 心筋細胞系列細胞への霊長類多能性幹細胞の分化

Country Status (10)

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US (2) US9062289B2 (enExample)
EP (1) EP1910518B1 (enExample)
JP (2) JP5560393B2 (enExample)
KR (2) KR20130099253A (enExample)
CN (1) CN101228264B (enExample)
AU (1) AU2006262329B2 (enExample)
CA (1) CA2611809C (enExample)
GB (1) GB2441718B (enExample)
IL (1) IL187611A (enExample)
WO (1) WO2007002136A2 (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2412383A1 (en) * 2006-07-28 2012-02-01 Children's Memorial Hospital Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells
US8106004B2 (en) * 2006-07-28 2012-01-31 Children's Memorial Hospital Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells
WO2009120762A2 (en) 2008-03-27 2009-10-01 Mount Sinai School Of Medicine Of New York University Human cardiovascular progenitor cells
CA2777552C (en) 2009-10-19 2019-05-21 Cellular Dynamics International, Inc. Cardiomyocyte production
US9181529B2 (en) 2010-10-19 2015-11-10 Cellular Dynamics International, Inc. Titration of differentiation medium components
JP6090855B2 (ja) 2010-11-17 2017-03-08 国立大学法人京都大学 心筋細胞および／または心筋前駆細胞増殖剤ならびに心筋細胞および／または心筋前駆細胞の増殖方法
US20140329314A1 (en) 2011-03-29 2014-11-06 Christopher O'Sullivan Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells
US9487752B2 (en) 2011-03-30 2016-11-08 Cellular Dynamics International, Inc. Priming of pluripotent stem cells for neural differentiation
JP5840855B2 (ja) 2011-03-30 2016-01-06 学校法人東京女子医科大学 胚性幹細胞から心筋シートを製造する方法
US9164093B2 (en) 2011-03-31 2015-10-20 Iheart Japan Corporation Cardiomyocyte marker
MY170940A (en) 2011-06-16 2019-09-19 Ge Video Compression Llc Entropy coding of motion vector differences
KR101966208B1 (ko) 2011-07-21 2019-04-09 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 환자로부터 유도 만능 줄기 세포들로부터의 심근 세포 및 그 사용 방법
GB201121101D0 (en) * 2011-12-08 2012-01-18 Nhs Blood & Transplant A method of preparing isolated cells and uses
EP2826855B1 (en) 2012-03-15 2018-08-29 iHeart Japan Corporation Myocardial sheet
JP6373253B2 (ja) 2012-07-17 2018-08-15 国立大学法人京都大学 新規心筋細胞マーカー
JP6429280B2 (ja) 2013-05-14 2018-11-28 国立大学法人京都大学 効率的な心筋細胞の誘導方法
CN105247041B (zh) 2013-05-31 2018-04-20 爱心细胞有限公司 组入有水凝胶的层叠细胞膜片
WO2014192312A1 (ja) * 2013-05-31 2014-12-04 国立大学法人 東京医科歯科大学 正常な内向きのカリウム電流特性を有するｉＰＳ細胞由来心筋モデル細胞
KR102423106B1 (ko) 2013-06-11 2022-07-21 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 SC-β 세포 및 조성물 그리고 그 생성 방법
EP3121276B1 (en) 2014-03-20 2019-04-17 Kyoto University Cardiomyocyte sorting method
EP3140395B1 (en) * 2014-05-06 2020-01-22 F. Hoffmann-La Roche AG Method for differentiation of pluripotent stem cells into cardiomyocytes
JP6265515B2 (ja) * 2014-09-16 2018-01-24 国立大学法人大阪大学 多能性幹細胞由来心筋細胞集団の製造方法
WO2016100930A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Methods for generating stem cell-derived b cells and methods of use thereof
WO2016100909A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF
WO2016100898A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof
US10556388B2 (en) * 2015-04-22 2020-02-11 Eastman Chemical Company Polyester-based tape composites for wood reinforcement
HK1254190A1 (zh) 2015-05-08 2019-07-12 President And Fellows Of Harvard College 通用供体干细胞和相关方法
AU2018370029B2 (en) 2017-11-15 2024-11-07 Vertex Pharmaceuticals Incorporated Islet cell manufacturing compositions and methods of use
WO2019189545A1 (ja) 2018-03-30 2019-10-03 国立大学法人京都大学 細胞の製造方法
US11401264B2 (en) 2018-03-30 2022-08-02 Orizuru Therapeutics, Inc. Heterocyclic compound
WO2019189554A1 (ja) 2018-03-30 2019-10-03 国立大学法人京都大学 心筋細胞成熟促進剤
EP3833365A4 (en) 2018-08-10 2022-05-11 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
TWI837161B (zh) 2018-08-10 2024-04-01 日商武田藥品工業股份有限公司 陽離子性脂質
CN112639111B (zh) 2018-08-10 2023-07-21 国立大学法人京都大学 使用阳离子性脂质的转染心肌细胞的方法
EP4017508A1 (en) 2019-08-23 2022-06-29 Sana Biotechnology, Inc. Cd24 expressing cells and uses thereof
MX2023001831A (es) 2020-08-13 2023-06-29 Sana Biotechnology Inc Métodos de tratamiento de pacientes sensibilizados con células hipoinmunogénicas y métodos y composiciones asociados.
KR20240013135A (ko) 2021-05-27 2024-01-30 사나 바이오테크놀로지, 인크. 조작된 hla-e 또는 hla-g를 포함하는 저면역원성 세포
AU2022309875A1 (en) 2021-07-14 2024-01-25 Sana Biotechnology, Inc. Altered expression of y chromosome-linked antigens in hypoimmunogenic cells
EP4384598A1 (en) 2021-08-11 2024-06-19 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions
WO2023019225A2 (en) 2021-08-11 2023-02-16 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions
EP4384544A1 (en) 2021-08-11 2024-06-19 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy
IL310702A (en) 2021-08-11 2024-04-01 Sana Biotechnology Inc Inducible systems for altering gene expression in hypoimmunogenic cells
KR20230073749A (ko) 2021-11-19 2023-05-26 주식회사 로킷헬스케어 박동형 심근 패치의 제조방법 및 이를 이용하여 제조된 박동형 심근 패치
WO2023183313A1 (en) 2022-03-22 2023-09-28 Sana Biotechnology, Inc. Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods
WO2024243236A2 (en) 2023-05-22 2024-11-28 Sana Biotechnology, Inc. Methods of delivery of islet cells and related methods
WO2025054202A1 (en) 2023-09-05 2025-03-13 Sana Biotechnology, Inc. Method of screening a sample comprising a transgene with a unique barcode
WO2025151838A1 (en) 2024-01-12 2025-07-17 Sana Biotechnology, Inc. Safety switches to control in vitro and in vivo proliferation of cell therapy products

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491632A (en) 1979-10-22 1985-01-01 The Massachusetts General Hospital Process for producing antibodies to hepatitis virus and cell lines therefor
US4444887A (en) 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
DE3167442D1 (en) 1980-07-07 1985-01-10 Nat Res Dev Improvements in or relating to cell lines
GB2197915B (en) 1986-11-19 1990-11-14 Rolls Royce Plc Improvements in or relating to fluid bearings
WO1992013066A1 (en) 1991-01-24 1992-08-06 Loyola University Of Chicago Mammalian cardiac myocyte cell line
US5543318A (en) 1991-06-12 1996-08-06 Smith; David A. Method of isolation, culture and proliferation of human atrial myocytes
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US5602301A (en) 1993-11-16 1997-02-11 Indiana University Foundation Non-human mammal having a graft and methods of delivering protein to myocardial tissue
US6015671A (en) 1995-06-07 2000-01-18 Indiana University Foundation Myocardial grafts and cellular compositions
DE4441327C1 (de) 1994-11-22 1995-11-09 Inst Pflanzengenetik & Kultur Embryonale Herzmuskelzellen, ihre Herstellung und ihre Verwendung
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
ATE322282T1 (de) 1996-08-16 2006-04-15 Mcw Res Found Inc Knochen morphogenetisches protein und fibroblasten wachstumsfaktor enthaltende zusammensetzungen und methoden zur induzierung der kardiogenese
US20020061837A1 (en) * 1996-09-05 2002-05-23 Lough John W. Bone morphogenetic protein and fibroblast growth factor compositions and methods for the induction of cardiogenesis
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
EP0986635A4 (en) 1997-01-10 2001-11-07 Life Technologies Inc SERUM SUBSTITUTE FOR EMBRYONIC STEM CELLS
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US6099832A (en) 1997-05-28 2000-08-08 Genzyme Corporation Transplants for myocardial scars
US6110459A (en) 1997-05-28 2000-08-29 Mickle; Donald A. G. Transplants for myocardial scars and methods and cellular preparations
DK1007631T4 (da) 1997-07-14 2009-04-27 Osiris Therapeutics Inc Hjertemuskelregeneration ved anvendelse af mesenkymale stamceller
EP1025204A4 (en) 1997-10-23 2001-02-28 Geron Corp Methods and materials for the growth of primate-derived primordial stem cells
DE19755800A1 (de) 1997-12-16 1999-06-17 Merck Patent Gmbh Cyclopeptidderivate
JP2002507407A (ja) 1998-03-23 2002-03-12 ザイモジェネティクス，インコーポレイティド 心臓由来幹細胞
IL138502A0 (en) 1998-04-09 2001-10-31 Bresagen Ltd Cell differentiation/ proliferation and maintenaince factor and uses thereof
AU5545499A (en) 1998-07-31 2000-02-21 Genzyme Corporation Improvement of cardiac function by mesenchymal stem cell transplantation
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US20020168766A1 (en) 2000-01-11 2002-11-14 Gold Joseph D. Genetically altered human pluripotent stem cells
IL129966A (en) 1999-05-14 2009-12-24 Technion Res & Dev Foundation ISOLATED HUMAN EMBRYOID BODIES (hEB) DERIVED FROM HUMAN EMBRYONIC STEM CELLS
AU783935B2 (en) 1999-06-18 2006-01-05 Indiana University Research And Technology Corporation Cardiomyocytes with enhanced proliferative potential, and methods for preparing and using same
EP1221956A2 (en) 1999-09-30 2002-07-17 McGILL UNIVERSITY Autologous marrow stem cell (msc) transplantation for myocardial regeneration
US6280718B1 (en) 1999-11-08 2001-08-28 Wisconsin Alumni Reasearch Foundation Hematopoietic differentiation of human pluripotent embryonic stem cells
AU784618B2 (en) 1999-12-28 2006-05-18 Kyowa Hakko Kogyo Co. Ltd. Cells capable of differentiating into heart muscle cells
US20020142457A1 (en) 1999-12-28 2002-10-03 Akihiro Umezawa Cell having the potentiality of differentiation into cardiomyocytes
WO2001051610A1 (en) 2000-01-14 2001-07-19 Bresagen Limited Ectoderm cell production
EP1248834A4 (en) 2000-01-21 2004-03-17 Univ Johns Hopkins CELLS FROM HUMAN EMBRYOID BODIES
JP2004504807A (ja) 2000-03-10 2004-02-19 アドヴァンスト　リサーチ　アンド　テクノロジー　インスティチュート、インコーポレイティッド 多分化能細胞および心筋細胞集団、並びに該集団への経路およびその使用
US20020061587A1 (en) 2000-07-31 2002-05-23 Piero Anversa Methods and compositions for the repair and/or regeneration of damaged myocardium
AU2001283088A1 (en) 2000-07-31 2002-02-25 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
AU8617301A (en) 2000-08-01 2002-02-13 Yissum Res Dev Co Directed differentiation of embryonic cells
US6534052B1 (en) 2000-09-05 2003-03-18 Yong-Fu Xiao Cardiac function comprising implantation of embryonic stem cell in which differentiation has been initiated
US6607720B1 (en) 2000-09-05 2003-08-19 Yong-Fu Xiao Genetically altered mammalian embryonic stem cells, their living progeny, and their therapeutic application for improving cardiac function after myocardial infarction
JP2004521877A (ja) 2000-11-22 2004-07-22 ジェロン コーポレイション 多能性幹細胞の同種移植片の寛容化
AU2002303343A1 (en) 2001-04-13 2002-10-28 Anterogen Co., Ltd. Methods and reagents for cell transplantation
US7732199B2 (en) * 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
IL159580A0 (en) 2001-07-12 2004-06-01 Geron Corp Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
IL159895A0 (en) 2001-07-20 2004-06-20 Technion Res & Dev Foundation Methods of generating human cardiac cells and tissues and uses thereof
AU2002317039B2 (en) 2001-07-24 2007-10-04 Es Cell International Pte Ltd Methods of inducing differentiation of stem cells
EP1463803B1 (en) 2001-12-07 2018-02-14 Asterias Biotherapeutics, Inc. Hematopoietic cells from human embryonic stem cells
US8298606B2 (en) 2002-03-08 2012-10-30 The Regents Of The University Of California Methods and compositions for stabilizing the myocardium
US7148062B2 (en) * 2002-03-15 2006-12-12 Wicell Research Institute, Inc. Method for generating primate trophoblasts
US7247477B2 (en) 2002-04-16 2007-07-24 Technion Research & Development Foundation Ltd. Methods for the in-vitro identification, isolation and differentiation of vasculogenic progenitor cells
US6898272B2 (en) * 2002-08-01 2005-05-24 Spirent Communications System and method for testing telecommunication devices
US7569222B2 (en) 2002-11-18 2009-08-04 Woerly Stephane Hydrogel membrane composition and use thereof
US20050031598A1 (en) 2002-12-10 2005-02-10 Shulamit Levenberg Engineering three-dimensional tissue structures using differentiating embryonic stem cells
AU2003901099A0 (en) 2003-03-11 2003-03-27 Es Cell International Pte Ltd. Methods of inducing differentiation of stem cells
US20030224411A1 (en) 2003-03-13 2003-12-04 Stanton Lawrence W. Genes that are up- or down-regulated during differentiation of human embryonic stem cells
US20050266554A1 (en) * 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US20050142121A1 (en) 2003-12-24 2005-06-30 Gold Joseph D. System for improving acceptance of tissue grafts made from embryonic stem cells
EP1725654B1 (en) * 2004-03-19 2019-05-01 Asterias Biotherapeutics, Inc. Method for making high purity cardiomyocyte preparations suitable for regenerative medicine
US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
US20050214938A1 (en) 2004-03-26 2005-09-29 Gold Joseph D Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
WO2006138718A2 (en) 2005-06-17 2006-12-28 Drexel University Three-dimensional scaffolds for tissue engineering made by processing complex extracts of natural extracellular matrices
JP2010530955A (ja) 2006-12-29 2010-09-16 ユニヴァーシティ オブ ワシントン 二重機能性非汚染表面および材料
WO2009099555A2 (en) 2008-01-30 2009-08-13 Corning Incorporated Synthetic surfaces for culturing cells in chemically defined media
US9115238B2 (en) 2009-05-28 2015-08-25 Corning Incorporated Swellable synthetic microcarriers for culturing cells

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