ATE322282T1 - Knochen morphogenetisches protein und fibroblasten wachstumsfaktor enthaltende zusammensetzungen und methoden zur induzierung der kardiogenese - Google Patents
Knochen morphogenetisches protein und fibroblasten wachstumsfaktor enthaltende zusammensetzungen und methoden zur induzierung der kardiogeneseInfo
- Publication number
- ATE322282T1 ATE322282T1 AT97936493T AT97936493T ATE322282T1 AT E322282 T1 ATE322282 T1 AT E322282T1 AT 97936493 T AT97936493 T AT 97936493T AT 97936493 T AT97936493 T AT 97936493T AT E322282 T1 ATE322282 T1 AT E322282T1
- Authority
- AT
- Austria
- Prior art keywords
- growth factor
- fibroblast growth
- methods
- bone morphogenetic
- morphogenetic protein
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 102000018233 Fibroblast Growth Factor Human genes 0.000 title abstract 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 title abstract 2
- 229940126864 fibroblast growth factor Drugs 0.000 title abstract 2
- 230000001939 inductive effect Effects 0.000 title abstract 2
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 title 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 title 1
- 229940112869 bone morphogenetic protein Drugs 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000006269 (delayed) early viral mRNA transcription Effects 0.000 abstract 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 230000001269 cardiogenic effect Effects 0.000 abstract 1
- 210000002064 heart cell Anatomy 0.000 abstract 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Vascular Medicine (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2406296P | 1996-08-16 | 1996-08-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE322282T1 true ATE322282T1 (de) | 2006-04-15 |
Family
ID=21818673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97936493T ATE322282T1 (de) | 1996-08-16 | 1997-08-13 | Knochen morphogenetisches protein und fibroblasten wachstumsfaktor enthaltende zusammensetzungen und methoden zur induzierung der kardiogenese |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0862453B1 (de) |
| JP (1) | JP3176377B2 (de) |
| AT (1) | ATE322282T1 (de) |
| AU (1) | AU725084B2 (de) |
| CA (1) | CA2235025C (de) |
| DE (1) | DE69735622T2 (de) |
| DK (1) | DK0862453T3 (de) |
| ES (1) | ES2262185T3 (de) |
| PT (1) | PT862453E (de) |
| WO (1) | WO1998006420A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0952845A1 (de) * | 1996-12-20 | 1999-11-03 | Creative Biomolecules, Inc. | Behandlung von säugetiermyocardium mit lokalem morphogen oder mit morphogenischen behandelten myogenischen vorläuferzellen |
| WO2000013710A2 (en) * | 1998-09-04 | 2000-03-16 | Scios Inc. | Hydrogel compositions for the controlled release administration of growth factors |
| KR20040022448A (ko) * | 2001-07-12 | 2004-03-12 | 제론 코포레이션 | 인간 다분화능 줄기 세포로부터 제조된 심근 세포 계통의세포 |
| CA2590338A1 (en) * | 2005-01-25 | 2006-08-03 | Five Prime Therapeutics, Inc. | Compositions and methods for treating cardiac conditions |
| KR101529317B1 (ko) | 2005-06-22 | 2015-06-16 | 아스테리아스 바이오세라퓨틱스, 인크. | 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| US5071655A (en) * | 1990-01-12 | 1991-12-10 | Baylink David J | Pharmaceutical combination for treatment of bone-wasting diseases |
-
1997
- 1997-08-13 CA CA002235025A patent/CA2235025C/en not_active Expired - Fee Related
- 1997-08-13 ES ES97936493T patent/ES2262185T3/es not_active Expired - Lifetime
- 1997-08-13 WO PCT/US1997/014229 patent/WO1998006420A1/en not_active Ceased
- 1997-08-13 AU AU39149/97A patent/AU725084B2/en not_active Ceased
- 1997-08-13 DK DK97936493T patent/DK0862453T3/da active
- 1997-08-13 JP JP50998398A patent/JP3176377B2/ja not_active Expired - Fee Related
- 1997-08-13 AT AT97936493T patent/ATE322282T1/de not_active IP Right Cessation
- 1997-08-13 EP EP97936493A patent/EP0862453B1/de not_active Expired - Lifetime
- 1997-08-13 DE DE69735622T patent/DE69735622T2/de not_active Expired - Fee Related
- 1997-08-13 PT PT97936493T patent/PT862453E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998006420A1 (en) | 1998-02-19 |
| EP0862453A1 (de) | 1998-09-09 |
| EP0862453B1 (de) | 2006-04-05 |
| AU725084B2 (en) | 2000-10-05 |
| JP3176377B2 (ja) | 2001-06-18 |
| JPH11511181A (ja) | 1999-09-28 |
| DK0862453T3 (da) | 2006-08-14 |
| PT862453E (pt) | 2006-08-31 |
| AU3914997A (en) | 1998-03-06 |
| EP0862453A4 (de) | 2000-11-29 |
| CA2235025C (en) | 2001-10-09 |
| ES2262185T3 (es) | 2006-11-16 |
| DE69735622D1 (de) | 2006-05-18 |
| DE69735622T2 (de) | 2007-04-12 |
| CA2235025A1 (en) | 1998-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0862453 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |