ATE231921T1 - Verfahren zur identifizierung von knochenwachstum modulatoren - Google Patents
Verfahren zur identifizierung von knochenwachstum modulatorenInfo
- Publication number
- ATE231921T1 ATE231921T1 AT96923207T AT96923207T ATE231921T1 AT E231921 T1 ATE231921 T1 AT E231921T1 AT 96923207 T AT96923207 T AT 96923207T AT 96923207 T AT96923207 T AT 96923207T AT E231921 T1 ATE231921 T1 AT E231921T1
- Authority
- AT
- Austria
- Prior art keywords
- bone growth
- growth modulators
- identifying bone
- identifying
- modulators
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000008468 bone growth Effects 0.000 title 1
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 abstract 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 abstract 1
- 108700008625 Reporter Genes Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 229940112869 bone morphogenetic protein Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002188 osteogenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Meat, Egg Or Seafood Products (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/458,434 US6083690A (en) | 1995-06-02 | 1995-06-02 | Methods and compositions for identifying osteogenic agents |
PCT/US1996/008197 WO1996038590A1 (en) | 1995-06-02 | 1996-05-31 | Methods and compositions for identifying osteogenic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE231921T1 true ATE231921T1 (de) | 2003-02-15 |
Family
ID=23820773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96923207T ATE231921T1 (de) | 1995-06-02 | 1996-05-31 | Verfahren zur identifizierung von knochenwachstum modulatoren |
Country Status (8)
Country | Link |
---|---|
US (1) | US6083690A (de) |
EP (1) | EP0832297B1 (de) |
JP (1) | JPH11506009A (de) |
AT (1) | ATE231921T1 (de) |
AU (1) | AU6377996A (de) |
CA (1) | CA2221621A1 (de) |
DE (1) | DE69626015D1 (de) |
WO (1) | WO1996038590A1 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5932716A (en) * | 1995-07-26 | 1999-08-03 | Creative Biomolecules, Inc. | Morphogen-responsive regulatory elements |
US6103491A (en) * | 1995-07-26 | 2000-08-15 | Creative Biomolecules, Inc. | Methods and compositions for identifying morphogen analogs |
US5834188A (en) * | 1995-07-26 | 1998-11-10 | Creative Biomolecule, Inc. | Methods and compositions for identifying morphogen analogs |
US7306903B1 (en) * | 1995-07-26 | 2007-12-11 | Curis, Inc. | Methods and compositions for identifying morphogen analogs |
US6090544A (en) * | 1995-07-26 | 2000-07-18 | Creative Biomolecules, Inc. | Methods and compositions for identifying morphogen analogs |
US6008208A (en) | 1995-10-23 | 1999-12-28 | Osteoscreen, Inc. | Compositions and methods for treating bone deficit conditions |
US5928940A (en) * | 1996-09-24 | 1999-07-27 | Creative Biomolecules, Inc. | Morphogen-responsive signal transducer and methods of use thereof |
JP2001509010A (ja) * | 1996-11-22 | 2001-07-10 | アクゾ・ノベル・エヌ・ベー | Bmp―4プロモーターならびに骨粗鬆症の予防および/または治療用の治療剤のスクリーニングにおけるその用途 |
US6376476B1 (en) * | 1996-12-13 | 2002-04-23 | Zymogenetics Corporation | Isoprenoid pathway inhibitors for stimulating bone growth |
WO1998054344A2 (en) * | 1997-05-29 | 1998-12-03 | Creative Biomolecules, Inc. | Modulators of morphogen expression and methods of identifying the same |
EP0890639A3 (de) * | 1997-07-09 | 2001-10-10 | Gesellschaft für biotechnologische Forschung mbH (GBF) | BPM2-induziertes cDNA und seine Verwendung |
US6649631B1 (en) | 1997-10-23 | 2003-11-18 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating bone deficit conditions |
JPH11313674A (ja) * | 1998-04-30 | 1999-11-16 | Hoechst Marion Roussel Kk | ヒトbmp−4プロモーターおよびこれを用いた骨関連物質の探索法 |
JPH11313675A (ja) * | 1998-04-30 | 1999-11-16 | Hoechst Marion Roussel Kk | ヒトbmp−7プロモーターおよびこれを用いた骨関連物質の探索法 |
JPH11313673A (ja) * | 1998-04-30 | 1999-11-16 | Hoechst Marion Roussel Kk | ヒトbmp−2プロモーターおよびこれを用いた骨関連物質の探索法 |
US6838436B1 (en) | 1998-07-10 | 2005-01-04 | Osteoscreen Inc. | Inhibitors of proteasomal activity for stimulating bone growth |
US6462019B1 (en) | 1998-07-10 | 2002-10-08 | Osteoscreen, Inc. | Inhibitors of proteasomal activity and production for stimulating bone growth |
US6902721B1 (en) * | 1998-07-10 | 2005-06-07 | Osteoscreen, Inc. | Inhibitors of proteasomal activity for stimulating bone growth |
US7052856B2 (en) * | 1999-10-05 | 2006-05-30 | The Regents Of The University Of California | NELL-1 enhanced bone mineralization |
US7687462B2 (en) * | 1999-10-05 | 2010-03-30 | The Regents Of The University Of California | Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition |
US7884066B2 (en) * | 1999-10-05 | 2011-02-08 | The Regents Of The University Of California | NELL-1 enhanced bone mineralization |
US20090060988A1 (en) * | 1999-10-05 | 2009-03-05 | Kang Ting | Nell-1 enhanced bone mineralization |
AU2002217843A1 (en) * | 2000-11-06 | 2002-05-15 | Thrasos, Inc. | Computer method and apparatus for classifying objects |
ATE354802T1 (de) * | 2000-11-06 | 2007-03-15 | Thrasos Inc | Methoden zum screening knochenmorphogenetishemimetika |
US20030087259A1 (en) * | 2001-04-18 | 2003-05-08 | Clancy Brian M. | Methods and compositions for regulating bone and cartilage formation |
US7251568B2 (en) * | 2001-04-18 | 2007-07-31 | Wyeth | Methods and compositions for regulating bone and cartilage formation |
US7041309B2 (en) * | 2002-06-13 | 2006-05-09 | Neuropro Technologies, Inc. | Spinal fusion using an HMG-CoA reductase inhibitor |
CN1753904A (zh) * | 2002-08-16 | 2006-03-29 | 惠氏公司 | 骨形态发生蛋白-2的雌激素效应元件及其使用方法 |
US7029006B2 (en) * | 2002-08-29 | 2006-04-18 | Canon Kabushiki Kaisha | Sheet feeding apparatus and image forming apparatus |
EP1551978A4 (de) * | 2002-09-13 | 2006-02-01 | Univ California | Durch nell-1 verbesserte knochenmineralisierung |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
ES2366950T3 (es) * | 2003-02-07 | 2011-10-26 | The Regents Of The University Of California | Sistemas de expresión de péptidos nell y actividad de formación ósea de péptidos nell. |
US20040254238A1 (en) * | 2003-04-07 | 2004-12-16 | Osteoscreen | Bone growth stimulation with NO/statin and other NO modulating combinations |
US7427677B2 (en) * | 2003-07-01 | 2008-09-23 | Academia Sinica | Expression of zebrafish bone morphogenetic protein 4 |
US7691607B2 (en) * | 2004-02-09 | 2010-04-06 | The Regents Of The University Of California | Expression system of NELL peptide |
CA2574953A1 (en) | 2004-07-26 | 2006-02-09 | Dow Global Technolgies Inc. | Process for improved protein expression by strain engineering |
US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
JP2008530227A (ja) | 2005-02-16 | 2008-08-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 骨状態を治療または予防する薬剤組成物 |
WO2006125868A1 (en) | 2005-05-27 | 2006-11-30 | Bbs-Bioactive Bone Substitutes Oy | Bone morphogenetic proteins containing a heparin binding site and osteogenic devices and pharmaceutical products containing thereof |
US7807627B2 (en) | 2005-05-27 | 2010-10-05 | Bbs-Bioactive Bone Substitutes Oy | Bone morphogenetic protein 4 and osteogenic devices and pharmaceutical products containing thereof |
AU2006292827B2 (en) | 2005-08-09 | 2013-02-14 | Revivicor, Inc. | Transgenic ungulates expressing CTLA4-IG and uses thereof |
US20080262633A1 (en) * | 2006-05-08 | 2008-10-23 | Williams Michelle Leroux | Cancellous bone treated with collagenase and essentially free of blood cells |
AU2007250080B2 (en) * | 2006-05-08 | 2011-08-18 | Nuvasive, Inc. | Cancellous bone treated with collagenase and essentially free of blood cells |
CN101688213A (zh) | 2007-04-27 | 2010-03-31 | 陶氏环球技术公司 | 用于快速筛选微生物宿主以鉴定某些在表达异源蛋白质方面具有改善的产量和/或质量的菌株的方法 |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US9216181B2 (en) | 2011-06-08 | 2015-12-22 | Southwest Research Institute | BMP-2 upregulating compounds for healing bone tissue and screening methods for selecting such compounds |
US10780197B1 (en) | 2012-10-29 | 2020-09-22 | Nuvasive, Inc. | Malleable, cryopreserved osteogenic compositions with viable cells |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
US5266683A (en) * | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
WO1992013091A1 (en) * | 1991-01-18 | 1992-08-06 | Oncogene Science, Inc. | Methods of transcriptionally modulating expression of oncogenes and tumor suppressor genes |
IL109990A (en) * | 1993-06-21 | 1999-06-20 | Lilly Co Eli | Materials and methods for screening anti-osteoporosis agents |
US5491084A (en) * | 1993-09-10 | 1996-02-13 | The Trustees Of Columbia University In The City Of New York | Uses of green-fluorescent protein |
-
1995
- 1995-06-02 US US08/458,434 patent/US6083690A/en not_active Expired - Fee Related
-
1996
- 1996-05-31 DE DE69626015T patent/DE69626015D1/de not_active Expired - Lifetime
- 1996-05-31 AT AT96923207T patent/ATE231921T1/de not_active IP Right Cessation
- 1996-05-31 CA CA002221621A patent/CA2221621A1/en not_active Abandoned
- 1996-05-31 EP EP96923207A patent/EP0832297B1/de not_active Expired - Lifetime
- 1996-05-31 JP JP8536715A patent/JPH11506009A/ja not_active Ceased
- 1996-05-31 WO PCT/US1996/008197 patent/WO1996038590A1/en active IP Right Grant
- 1996-05-31 AU AU63779/96A patent/AU6377996A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE69626015D1 (de) | 2003-03-06 |
CA2221621A1 (en) | 1996-12-05 |
WO1996038590A1 (en) | 1996-12-05 |
AU6377996A (en) | 1996-12-18 |
EP0832297A1 (de) | 1998-04-01 |
US6083690A (en) | 2000-07-04 |
EP0832297B1 (de) | 2003-01-29 |
JPH11506009A (ja) | 1999-06-02 |
EP0832297A4 (de) | 1999-10-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |