DE69633872D1 - Screening-verfahren zur identifizierung von neuen antibiotika - Google Patents
Screening-verfahren zur identifizierung von neuen antibiotikaInfo
- Publication number
- DE69633872D1 DE69633872D1 DE69633872T DE69633872T DE69633872D1 DE 69633872 D1 DE69633872 D1 DE 69633872D1 DE 69633872 T DE69633872 T DE 69633872T DE 69633872 T DE69633872 T DE 69633872T DE 69633872 D1 DE69633872 D1 DE 69633872D1
- Authority
- DE
- Germany
- Prior art keywords
- relates
- methods
- screening procedure
- identifying new
- new antibiotics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9123—Phosphotransferases in general with a nitrogenous group as acceptor (2.7.3), e.g. histidine kinases
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/528,737 US5747276A (en) | 1995-09-15 | 1995-09-15 | Screening methods for the identification of novel antibiotics |
PCT/US1996/014652 WO1997010358A1 (en) | 1995-09-15 | 1996-09-12 | Screening methods for the identification of novel antibiotics |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69633872D1 true DE69633872D1 (de) | 2004-12-23 |
Family
ID=24106955
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69633872T Expired - Lifetime DE69633872D1 (de) | 1995-09-15 | 1996-09-12 | Screening-verfahren zur identifizierung von neuen antibiotika |
Country Status (8)
Country | Link |
---|---|
US (1) | US5747276A (de) |
EP (1) | EP0883691B1 (de) |
JP (1) | JPH11512523A (de) |
AT (1) | ATE282713T1 (de) |
AU (1) | AU717782B2 (de) |
CA (1) | CA2232173A1 (de) |
DE (1) | DE69633872D1 (de) |
WO (1) | WO1997010358A1 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3122497A (en) * | 1996-05-14 | 1997-12-05 | University Of Manitoba | Solid-phase activity assay for biologically active substance |
US6043045A (en) * | 1996-09-12 | 2000-03-28 | The Scripps Research Institute | Screening methods for the identification of novel antibiotics |
US6518037B2 (en) * | 1999-11-12 | 2003-02-11 | University Of Iowa Research Foundation | Two-component system that controls bacterial membrane synthesis |
US20040171062A1 (en) * | 2002-02-28 | 2004-09-02 | Plexxikon, Inc. | Methods for the design of molecular scaffolds and ligands |
EP1499741A4 (de) * | 2002-03-13 | 2006-07-05 | Univ Creighton | Vorrichtung und verfahren zum nachweis antibiotisch-inaktivierender enzyme |
US7291480B2 (en) * | 2002-03-13 | 2007-11-06 | Black Jennifer A | Device and method for detecting antibiotic-inactivating enzymes |
US20050048573A1 (en) * | 2003-02-03 | 2005-03-03 | Plexxikon, Inc. | PDE5A crystal structure and uses |
WO2004078923A2 (en) * | 2003-02-28 | 2004-09-16 | Plexxikon, Inc. | Pyk2 crystal structure and uses |
US20050079548A1 (en) * | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
JP4845730B2 (ja) | 2003-07-17 | 2011-12-28 | プレキシコン,インコーポレーテッド | Ppar活性化合物 |
US7348338B2 (en) * | 2003-07-17 | 2008-03-25 | Plexxikon, Inc. | PPAR active compounds |
US20050164300A1 (en) * | 2003-09-15 | 2005-07-28 | Plexxikon, Inc. | Molecular scaffolds for kinase ligand development |
US20070066641A1 (en) * | 2003-12-19 | 2007-03-22 | Prabha Ibrahim | Compounds and methods for development of RET modulators |
CA2550361C (en) | 2003-12-19 | 2014-04-29 | Prabha Ibrahim | Compounds and methods for development of ret modulators |
JP2008503446A (ja) | 2004-05-06 | 2008-02-07 | プレキシコン,インコーポレーテッド | Pde4b阻害剤及びその使用 |
US7498342B2 (en) * | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
AU2005265017A1 (en) * | 2004-06-17 | 2006-01-26 | Plexxikon, Inc. | Azaindoles modulating c-kit activity and uses therefor |
US7605168B2 (en) * | 2004-09-03 | 2009-10-20 | Plexxikon, Inc. | PDE4B inhibitors |
WO2006060456A2 (en) * | 2004-11-30 | 2006-06-08 | Plexxikon, Inc. | Indole derivatives for use as ppar ppar active compounds |
US20060160135A1 (en) * | 2004-12-08 | 2006-07-20 | Weiru Wang | SF-1 and LRH-1 modulator development |
MX2007014377A (es) * | 2005-05-17 | 2008-02-06 | Plexxikon Inc | Inhibidores de proteina cinasa de derivados de pirrol (2,3-b) piridina. |
BRPI0611863B1 (pt) * | 2005-06-22 | 2021-11-23 | Plexxikon, Inc | Composto, bem como composição e kit compreendendo o mesmo, composto intermediário na preparação do mesmo, método para tratamento e uso do mesmo |
US7452691B2 (en) * | 2005-07-07 | 2008-11-18 | Creighton University | Device and method for detecting antibiotic inactivating enzymes |
KR20080047591A (ko) * | 2005-09-07 | 2008-05-29 | 플렉시콘, 인코퍼레이티드 | Ppar 조절인자로서 사용하기 위한 1,3-이치환된 인돌유도체 |
WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
PE20121126A1 (es) * | 2006-12-21 | 2012-08-24 | Plexxikon Inc | Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa |
WO2008079909A1 (en) * | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
RU2009122670A (ru) | 2006-12-21 | 2011-01-27 | Плекссикон, Инк. (Us) | Соединения и способы для модуляции киназ и показания к их применению |
PE20090159A1 (es) * | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
EP2170830B1 (de) | 2007-07-17 | 2014-10-15 | Plexxikon, Inc. | 2-FLUORO-BENZOSULFONAMID-VERBINDUNGEN ALS Raf-KINASE-MODULATOREN |
MY172424A (en) * | 2009-04-03 | 2019-11-25 | Hoffmann La Roche | Propane- i-sulfonic acid {3- (4-chloro-phenyl)-1h-pyrrolo [2, 3-b] pyridine-3-carconyl] -2, 4-difluoro-phenyl} -amide compositions and uses thereof |
US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
BR112012012156A2 (pt) | 2009-11-06 | 2015-09-08 | Plexxikon Inc | compostos e métodos para modulação de cinase, e indicações para esta |
TR201816421T4 (tr) | 2011-02-07 | 2018-11-21 | Plexxikon Inc | Kinaz modülasyonu için bileşikler ve metotlar ve bunların endikasyonları. |
AR085279A1 (es) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
US11452714B2 (en) | 2017-05-23 | 2022-09-27 | Regents Of The University Of Minnesota | Antibacterial agents including histidine kinase inhibitors |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3129493A (en) * | 1991-11-12 | 1993-06-15 | Promega Corporation | Non-radioactive enzyme assay |
-
1995
- 1995-09-15 US US08/528,737 patent/US5747276A/en not_active Expired - Fee Related
-
1996
- 1996-09-12 EP EP96931544A patent/EP0883691B1/de not_active Expired - Lifetime
- 1996-09-12 JP JP9512106A patent/JPH11512523A/ja not_active Ceased
- 1996-09-12 WO PCT/US1996/014652 patent/WO1997010358A1/en active IP Right Grant
- 1996-09-12 AU AU70194/96A patent/AU717782B2/en not_active Ceased
- 1996-09-12 DE DE69633872T patent/DE69633872D1/de not_active Expired - Lifetime
- 1996-09-12 AT AT96931544T patent/ATE282713T1/de not_active IP Right Cessation
- 1996-09-12 CA CA002232173A patent/CA2232173A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0883691B1 (de) | 2004-11-17 |
CA2232173A1 (en) | 1997-03-20 |
EP0883691A4 (de) | 2000-10-25 |
EP0883691A1 (de) | 1998-12-16 |
JPH11512523A (ja) | 1999-10-26 |
AU717782B2 (en) | 2000-03-30 |
AU7019496A (en) | 1997-04-01 |
WO1997010358A1 (en) | 1997-03-20 |
US5747276A (en) | 1998-05-05 |
ATE282713T1 (de) | 2004-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |