CN101228264B - 使灵长类多能干细胞分化成心肌细胞系细胞 - Google Patents

使灵长类多能干细胞分化成心肌细胞系细胞 Download PDF

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CN101228264B
CN101228264B CN200680022866.6A CN200680022866A CN101228264B CN 101228264 B CN101228264 B CN 101228264B CN 200680022866 A CN200680022866 A CN 200680022866A CN 101228264 B CN101228264 B CN 101228264B
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cells
bmp
cell
activin
cardiomyocyte
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CN101228264A (zh
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J·D·戈德
M·哈萨尼波
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ASTERIAS BIOTHERAPY CORP
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
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    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

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CN200680022866.6A 2005-06-22 2006-06-20 使灵长类多能干细胞分化成心肌细胞系细胞 Expired - Fee Related CN101228264B (zh)

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US69314105P 2005-06-22 2005-06-22
US60/693,141 2005-06-22
PCT/US2006/024060 WO2007002136A2 (en) 2005-06-22 2006-06-20 Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells

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CN101228264A CN101228264A (zh) 2008-07-23
CN101228264B true CN101228264B (zh) 2017-12-26

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US (2) US9062289B2 (enExample)
EP (1) EP1910518B1 (enExample)
JP (2) JP5560393B2 (enExample)
KR (2) KR20130099253A (enExample)
CN (1) CN101228264B (enExample)
AU (1) AU2006262329B2 (enExample)
CA (1) CA2611809C (enExample)
GB (1) GB2441718B (enExample)
IL (1) IL187611A (enExample)
WO (1) WO2007002136A2 (enExample)

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IL187611A (en) 2012-12-31
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AU2006262329A1 (en) 2007-01-04
KR20080030026A (ko) 2008-04-03
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US20150284684A1 (en) 2015-10-08
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US9062289B2 (en) 2015-06-23
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