DK1007631T4 - Hjertemuskelregeneration ved anvendelse af mesenkymale stamceller - Google Patents

Hjertemuskelregeneration ved anvendelse af mesenkymale stamceller

Info

Publication number
DK1007631T4
DK1007631T4 DK98934507T DK98934507T DK1007631T4 DK 1007631 T4 DK1007631 T4 DK 1007631T4 DK 98934507 T DK98934507 T DK 98934507T DK 98934507 T DK98934507 T DK 98934507T DK 1007631 T4 DK1007631 T4 DK 1007631T4
Authority
DK
Denmark
Prior art keywords
cells
mesenchymal stem
stem cells
cardiac muscle
muscle regeneration
Prior art date
Application number
DK98934507T
Other languages
English (en)
Other versions
DK1007631T3 (da
Inventor
Mark F Pittenger
Stephen L Gordon
Alastair Morgan Mackay
Original Assignee
Osiris Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21980718&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1007631(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Osiris Therapeutics Inc filed Critical Osiris Therapeutics Inc
Application granted granted Critical
Publication of DK1007631T3 publication Critical patent/DK1007631T3/da
Publication of DK1007631T4 publication Critical patent/DK1007631T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
DK98934507T 1997-07-14 1998-07-14 Hjertemuskelregeneration ved anvendelse af mesenkymale stamceller DK1007631T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5291097P 1997-07-14 1997-07-14
PCT/US1998/014520 WO1999003973A1 (en) 1997-07-14 1998-07-14 Cardiac muscle regeneration using mesenchymal stem cells

Publications (2)

Publication Number Publication Date
DK1007631T3 DK1007631T3 (da) 2006-03-06
DK1007631T4 true DK1007631T4 (da) 2009-04-27

Family

ID=21980718

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98934507T DK1007631T4 (da) 1997-07-14 1998-07-14 Hjertemuskelregeneration ved anvendelse af mesenkymale stamceller

Country Status (10)

Country Link
US (1) US6387369B1 (da)
EP (1) EP1007631B2 (da)
JP (1) JP4562816B2 (da)
AT (1) ATE307195T1 (da)
AU (1) AU8401498A (da)
CA (1) CA2296704C (da)
DE (1) DE69831957T3 (da)
DK (1) DK1007631T4 (da)
ES (1) ES2251773T5 (da)
WO (1) WO1999003973A1 (da)

Families Citing this family (265)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974571B2 (en) * 1995-03-28 2005-12-13 Thomas Jefferson University Isolated stromal cells and methods of using the same
US20030103951A1 (en) * 1997-07-14 2003-06-05 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
US7514074B2 (en) 1997-07-14 2009-04-07 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
WO1999046366A1 (en) * 1998-03-13 1999-09-16 Osiris Therapeutics, Inc. Uses for humane non-autologous mesenchymal stem cells
EP1894997A1 (en) * 1998-07-31 2008-03-05 Genzyme Corporation Improvement of cardiac function by mesenchymal stem cell transplantation
CA2339182C (en) * 1998-07-31 2010-04-06 Genzyme Corporation Improvement of cardiac function by mesenchymal stem cell transplantation
AU6056299A (en) * 1998-09-21 2000-04-10 Musc Foundation For Research Development Non-hematopoietic cells, including cardiomyocytes and skeletal muscle cells, derived from hematopoietic stem cells and methods of making and using them
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US6777231B1 (en) 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
US20030082152A1 (en) 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
US6635249B1 (en) * 1999-04-23 2003-10-21 Cenes Pharmaceuticals, Inc. Methods for treating congestive heart failure
US20050158289A1 (en) * 1999-07-07 2005-07-21 Simmons Paul J. Mesenchymal precursor cell and use thereof in the repair of bone defects and fractures in mammals
US8062675B2 (en) 1999-07-07 2011-11-22 Angioblast Systems, Inc. Mesenchymal precursor cell
US7670628B2 (en) * 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
AUPQ147799A0 (en) * 1999-07-07 1999-07-29 Medvet Science Pty. Ltd. Mesenchymal precursor cell
AU2003901668A0 (en) * 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
US7015037B1 (en) * 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US8252280B1 (en) 1999-08-05 2012-08-28 Regents Of The University Of Minnesota MAPC generation of muscle
US8147824B2 (en) 1999-08-05 2012-04-03 Athersys, Inc. Immunomodulatory properties of multipotent adult progenitor cells and uses thereof
US8075881B2 (en) * 1999-08-05 2011-12-13 Regents Of The University Of Minnesota Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure
EP1903107A1 (en) * 1999-09-24 2008-03-26 Cybios LLC Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
EP1221956A2 (en) * 1999-09-30 2002-07-17 McGILL UNIVERSITY Autologous marrow stem cell (msc) transplantation for myocardial regeneration
EP1254952A4 (en) * 1999-12-28 2004-09-22 Kyowa Hakko Kogyo Kk CELLS WHICH CAN INDUCE DIFFERENTIATION IN CARDIAC MUSCLE CELLS
US20100303769A1 (en) * 2000-04-06 2010-12-02 Franco Wayne P Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease
US7166280B2 (en) * 2000-04-06 2007-01-23 Franco Wayne P Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease
US20110091428A1 (en) * 2000-07-31 2011-04-21 New York Medical College Compositions of adult organ stem cells and uses thereof
US7862810B2 (en) * 2000-07-31 2011-01-04 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
AU2001284695A1 (en) * 2000-07-31 2002-02-13 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
US7214371B1 (en) 2000-09-01 2007-05-08 Ben-Gurion University Of The Negev Research & Development Authority Tissue engineered biografts for repair of damaged myocardium
US7560280B2 (en) * 2000-11-03 2009-07-14 Kourion Therapeutics Gmbh Human cord blood derived unrestricted somatic stem cells (USSC)
DE10056465A1 (de) * 2000-11-14 2002-07-18 Rosemarie Daig Zellkonstrukte erhältlich aus mesenchymalen Stammzellen und davon ableitbaren Zellen und ihre Verwendung
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
CA2678490A1 (en) 2000-12-06 2002-06-13 Robert J. Hariri Isolated placental perfusate and placental cells isolated therefrom
WO2002064157A2 (en) * 2001-01-23 2002-08-22 Boston Scientific Corporation Localized myocardial injection method for treating ischemic myocardium
JP2004528021A (ja) * 2001-02-14 2004-09-16 アンスロジェネシス コーポレーション 分娩後の哺乳動物の胎盤、その使用およびそれに由来する胎盤幹細胞
KR101132545B1 (ko) * 2001-02-14 2012-04-02 안트로제네시스 코포레이션 산후 포유류의 태반, 이의 용도 및 태반 줄기세포
WO2002084281A1 (en) 2001-04-13 2002-10-24 Anterogen Co., Ltd. Encapsulated cell indicator system
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
CN1543500B (zh) * 2001-07-12 2014-04-09 杰龙公司 从人多能干细胞产生心肌细胞系细胞
ITRM20010550A1 (it) * 2001-09-11 2003-03-11 Giulio Cossu Metodo per indurre il differenziamento di cellule endoteliali in cardiomiociti.
CA2465672A1 (en) * 2001-09-19 2003-03-27 Henry Ford Health System Cardiac transplantation of stem cells for the treatment of heart failure
US20030082153A1 (en) 2001-10-22 2003-05-01 The Government Of The United States Of America Stem cells that transform to beating cardiomyocytes
CN1612691A (zh) * 2001-11-08 2005-05-04 加利福尼亚大学董事会 纠正心脏传导障碍的方法和组合物
KR101083454B1 (ko) 2001-12-07 2011-11-16 사이토리 테라퓨틱스, 인크. 처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한 시스템 및 방법
US7651684B2 (en) 2001-12-07 2010-01-26 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US8404229B2 (en) 2001-12-07 2013-03-26 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to treat acute tubular necrosis
US7771716B2 (en) * 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US7514075B2 (en) 2001-12-07 2009-04-07 Cytori Therapeutics, Inc. Systems and methods for separating and concentrating adipose derived stem cells from tissue
US7595043B2 (en) 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US9597395B2 (en) * 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US8105580B2 (en) 2001-12-07 2012-01-31 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to promote wound healing
AU2002226683A1 (en) * 2002-01-17 2003-07-30 Cardio Incorporated Complex therapy for tissue regeneration
WO2003073998A2 (en) * 2002-03-02 2003-09-12 Board Of Regents, The University Of Texas System Local production and/or delivery of anti-cancer agents by stromal cell precursors
WO2003093433A2 (en) 2002-05-02 2003-11-13 Regents Of The University Of Minnesota Fibrin-based biomatrix
WO2003094697A2 (en) * 2002-05-08 2003-11-20 The Regents Of The University Of California Methods and compositions for correction of cardiac conduction disturbances
US20040067221A1 (en) * 2002-05-22 2004-04-08 Medtronic, Inc. Cell delivery fluid for prevention of cell settling in delivery system
AU2003259152A1 (en) * 2002-07-23 2004-02-09 Boston Scientific Limited Cell therapy for regeneration
US20050271639A1 (en) * 2002-08-22 2005-12-08 Penn Marc S Genetically engineered cells for therapeutic applications
AR047712A1 (es) * 2002-09-07 2006-02-15 Royal Veterinary College Metodo de tratamiento de una lesion de tejido esqueletico blando natural administrando una composicion de celulas madre mesenquimatosas
JP2006505380A (ja) * 2002-11-05 2006-02-16 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド 間葉幹細胞およびその使用方法
US7470538B2 (en) * 2002-12-05 2008-12-30 Case Western Reserve University Cell-based therapies for ischemia
US20040258670A1 (en) * 2002-12-05 2004-12-23 Case Western Reserve University Cell-based therapies for ischemia
US7794702B2 (en) * 2003-01-15 2010-09-14 The Trustees Of Columbia University In The City Of New York Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures
US20050002914A1 (en) * 2003-01-15 2005-01-06 Rosen Michael R. Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures
US20040197310A1 (en) * 2003-02-12 2004-10-07 Sanberg Paul R. Compositions and methods for using umbilical cord progenitor cells in the treatment of myocardial infarction
AU2011253681B2 (en) * 2003-03-28 2014-04-10 Mesoblast, Inc. Perivascular mesenchymal precursor cell induced blood vessel formation
CA2521217C (en) * 2003-04-01 2013-05-14 United States Of America Department Of Veteran's Affairs Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction
US20040213770A1 (en) * 2003-04-22 2004-10-28 Endobionics, Inc. Methods and systems for treating ischemic cardiac and other tissues
WO2004110270A1 (en) * 2003-06-12 2004-12-23 Regents Of The University Of Minnesota Directing cells to target tissues or organs
US8367410B2 (en) * 2003-06-20 2013-02-05 Massachusetts Institute Of Technology Application of electrical stimulation for functional tissue engineering in vitro and in vivo
NZ544828A (en) * 2003-06-25 2008-10-31 Ottawa Health Research Inst Use of cardiotrophin to modulate stem cell proliferation
PL1649013T3 (pl) 2003-06-27 2016-07-29 Depuy Synthes Products Inc Regeneracja i naprawa chrząstki i kości z wykorzystaniem komórek poporodowych
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US20050013870A1 (en) * 2003-07-17 2005-01-20 Toby Freyman Decellularized extracellular matrix of conditioned body tissues and uses thereof
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
CA2443423A1 (en) * 2003-09-30 2005-03-30 Darren H. Freed Use of cardiotrophon-1 to promote wound healing and counteract overt fibrosis
WO2005042723A2 (en) * 2003-10-28 2005-05-12 Caritas St. Elizabeth's Medical Center Of Boston, Inc. Novel multipotent stem cells and use thereof
EP1699523A4 (en) * 2003-12-24 2008-05-21 Univ Columbia CREATION OF ATRIOVENTRICULAR BIOLOGICAL DERIVATION TO COMPENSATE FOR ATRIOVENTRICULAR BLOCKING
US7840263B2 (en) * 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US20050214938A1 (en) * 2004-03-26 2005-09-29 Gold Joseph D Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
US7452718B2 (en) * 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
DE602005017877D1 (de) * 2004-03-30 2010-01-07 Boston Scient Ltd Restenose-therapie mit mesenchym-stammzellen
WO2005099758A2 (en) * 2004-04-17 2005-10-27 The Board Of Trustees The Leland Standford Junior University Injectable bioartificial tissue matrix
JP2007536935A (ja) * 2004-05-14 2007-12-20 ベクトン・ディキンソン・アンド・カンパニー 間葉幹細胞の無血清増殖のための細胞培養環境
US20050277124A1 (en) * 2004-06-10 2005-12-15 White Steven M Cardiac conduction system cells and uses thereof
CA2571315C (en) * 2004-06-21 2017-02-14 The Cleveland Clinic Foundation Ccr ligands for stem cell homing
JP2008506416A (ja) * 2004-07-19 2008-03-06 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク 遺伝子組み換えされた細胞が合胞体の機能を変える効果を監視するための分析システム
ES2626234T3 (es) 2004-07-30 2017-07-24 Mayo Foundation For Medical Education And Research Tratamiento de tejido cardiovascular
US7828711B2 (en) * 2004-08-16 2010-11-09 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular growth and regeneration using ventricular assist device
US8513011B2 (en) * 2004-08-26 2013-08-20 Biotech Research Ventures Pte Limited Methods and compositions for culturing cardiomyocyte-like cells
US7785582B2 (en) * 2004-09-07 2010-08-31 Johnson Lanny L Use of synovium and omentum for tissue engineering
US8182806B2 (en) * 2004-09-07 2012-05-22 Johnson Lanny L Synovial villi for use with tissue engineering
US20060051328A1 (en) * 2004-09-07 2006-03-09 Johnson Lanny L Mobilization of cells via physical means
KR20070085288A (ko) 2004-09-24 2007-08-27 안지오블라스트 시스템스 인코퍼레이티드 간엽 전구세포의 증식 및/또는 생존성 증강 방법
US20070072294A1 (en) * 2004-09-30 2007-03-29 Doronin Sergey V Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division
US20060234375A1 (en) * 2004-09-30 2006-10-19 Doronin Sergey V Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division
WO2006037103A2 (en) * 2004-09-30 2006-04-06 The Trustees Of Columbia University In The City Of New York The use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US20080267921A1 (en) * 2004-11-08 2008-10-30 Johns Hopkins University Cardiac Stem Cells
US8060219B2 (en) 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
CA2512667A1 (en) * 2005-01-07 2006-07-07 Takahiro Ochiya Human hepatocyte-like cells and uses thereof
US20060180187A1 (en) * 2005-02-14 2006-08-17 Squeegit, Inc. Window cleaning apparatus
US20060263338A1 (en) * 2005-03-04 2006-11-23 Jacoby Douglas B Catheter-based delivery of Skeletal Myoblasts to the Myocardium of Damaged Hearts
US20100028312A1 (en) * 2005-03-24 2010-02-04 Caritas St. Elizabeth Medical Center of Boston Inc Stably transformed bone marrow-derived cells and uses thereof
CN103356707B (zh) 2005-03-31 2016-07-06 斯丹姆涅恩有限公司 制备用以治疗伤口或糖尿病性神经病引发的溃疡,或预防手术后疝形成的药物的方法
CA2608048A1 (en) * 2005-05-10 2006-11-16 United States Of America Department Of Veteran's Affairs Therapy of kidney diseases and multiorgan failure with mesenchymal stem cells and mesenchymal stem cell conditioned media
EP2465923B1 (en) * 2005-05-25 2018-04-11 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
KR101529317B1 (ko) 2005-06-22 2015-06-16 아스테리아스 바이오세라퓨틱스, 인크. 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화
US8568761B2 (en) * 2005-07-15 2013-10-29 Cormatrix Cardiovascular, Inc. Compositions for regenerating defective or absent myocardium
US7531355B2 (en) 2005-07-29 2009-05-12 The Regents Of The University Of California Methods and compositions for smooth muscle reconstruction
US7927630B2 (en) * 2005-09-12 2011-04-19 Johnson Lanny L Use of autologous sediment from fluid aspirates as vehicles for drug delivery
US8518349B2 (en) 2005-09-12 2013-08-27 Lanny Johnson Use of autologous sediment from fluid aspirates as vehicles for drug delivery
PE20070771A1 (es) 2005-10-13 2007-08-11 Anthrogenesis Corp Inmunomodulacion mediante el uso de celulas madres de la placenta
US20090155220A1 (en) * 2005-10-20 2009-06-18 Caritas St. Elizabeth's Medical Center Of Boston Use of Bone-Marrow Derived Stem Cells to Treat Ischemia
EP2267114B1 (en) * 2005-10-28 2014-03-12 Universität Zürich Tissue engineering using pure populations of isolated non-embryoblastic fetal cells
US7713232B2 (en) 2005-11-04 2010-05-11 Medrad, Inc. System for washing and processing of cells for delivery thereof to tissue
US8182444B2 (en) * 2005-11-04 2012-05-22 Medrad, Inc. Delivery of agents such as cells to tissue
US10117900B2 (en) 2005-11-09 2018-11-06 Athersys, Inc. MAPC treatment of brain injuries and diseases
US11000546B2 (en) 2005-11-09 2021-05-11 Athersys, Inc. Immunomodulatory properties of MAPCs and uses thereof
CN101374946B (zh) 2005-12-16 2017-07-18 伊西康公司 用于在组织相容性不匹配的移植中抑制有害的免疫反应的组合物和方法
US7534607B1 (en) 2005-12-27 2009-05-19 Industrial Technology Research Institute Method of producing cardiomyocytes from mesenchymal stem cells
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
CN101389754A (zh) 2005-12-29 2009-03-18 人类起源公司 胎盘干细胞和第二来源干细胞的联合培养
ES2708933T3 (es) 2005-12-29 2019-04-12 Celularity Inc Poblaciones de células madre placentarias
EP3345610A1 (en) 2006-01-23 2018-07-11 Athersys, Inc. Mapc therapeutics without adjunctive immunosuppressive treatment
US20070178137A1 (en) * 2006-02-01 2007-08-02 Toby Freyman Local control of inflammation
US8071380B2 (en) 2006-02-16 2011-12-06 Fondazione Centro San Raffaele Del Monte Tabor Skeletal muscle periangioblasts and cardiac mesangioblasts, method for isolation and uses thereof
ITPA20060008A1 (it) * 2006-03-14 2007-09-15 Luciano Ciuro Sistema per impianto di cellule staminali intracardiaco secondo metodo ciuro; pseudonimo del sistema "spyder".
US20070253937A1 (en) * 2006-04-26 2007-11-01 Young-Sup Yoon Novel multipotent stem cells and use thereof
WO2007139551A1 (en) * 2006-05-30 2007-12-06 Cytori Therapeutics, Inc. Systems and methods for manipulation of regenerative cells from adipose tissue
US20130122108A1 (en) * 2006-06-06 2013-05-16 Robert G Matheny Compositions for Regenerating Defective or Absent Myocardium
AU2007258514A1 (en) * 2006-06-09 2007-12-21 Anthrogenesis Corporation Placental niche and use thereof to culture stem cells
US20070293893A1 (en) * 2006-06-14 2007-12-20 Craig Stolen Method and apparatus for preconditioning of cells
US9765298B2 (en) 2006-07-24 2017-09-19 Mayo Foundation For Medical Education And Research Methods and materials for providing cardiac cells
WO2008013863A2 (en) * 2006-07-26 2008-01-31 Cytori Therapeutics, Inc. Generation of adipose tissue and adipocytes
US7993918B2 (en) * 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
US20090035286A1 (en) * 2006-08-08 2009-02-05 Minguell Jose J Intracoronary, intracardiac, or intravenous infusion of a mixture of autologous bone marrow derived mononuclear cells and autologous bone marrow derived mesenchymal stem cells for utilization and rescue of infarcted myocardium
US20080038229A1 (en) * 2006-08-08 2008-02-14 Minguell Jose J Intracoronary injection of a mixture of autologous bone marrow derived mononuclear cells and autologous bone marrow derived mesenchymal stem cells for utilization and rescue of infarcted myocardium
US20110044950A1 (en) * 2006-08-08 2011-02-24 Minguell Jose J Infusion of a Mixture of Autologous Bone Marrow-Derived Mononuclear Cells and Autologous or Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells for Treating Myocardial and/or Cardiovascular Disorders
WO2008040027A2 (en) * 2006-09-28 2008-04-03 The Regents Of The University Of California Directed differentiation and maturation of stem cell-derived cardiomyocytes
US20080086111A1 (en) * 2006-10-09 2008-04-10 Medrad, Inc. Fluid delivery systems and volume metering in cell delivery
WO2008054819A2 (en) * 2006-11-02 2008-05-08 The General Hospital Corporation Cardiovascular stem cells, methods for stem cell isolation, and uses thereof
DE602007012290D1 (de) 2006-11-03 2011-03-10 Aastrom Biosciences Inc Mischzell-populationen für die gewebereparatur und trenntechnik für die zellaufbereitung
EP2087098A4 (en) * 2006-11-09 2010-03-31 Univ Johns Hopkins DEDIFFERENTIATION OF ADULT MAMMALIAN CARDIOMYCYTES INTO CARDIAC STEM CELLS
CN101573442A (zh) * 2006-11-09 2009-11-04 J·大卫格莱斯顿学会 诱导心肌细胞形成的方法
WO2008085229A2 (en) * 2006-11-15 2008-07-17 Arteriocyte Inc. Cell-based therapies for treating liver disease
CA2670497A1 (en) * 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Endodermal progenitor cells
RS52921B (en) 2007-02-12 2014-02-28 Anthrogenesis Corporation TREATMENT OF INFLAMMATORY DISEASES USING PLACENTAL CELL CELLS
ATE530638T1 (de) 2007-04-26 2011-11-15 Univ Ramot Pluripotente autologe stammzellen aus der mündlichen oder gastrointestinalen schleimhaut
TWM322542U (en) * 2007-05-23 2007-11-21 Universal Scient Ind Co Ltd Testing machine
US20080300642A1 (en) * 2007-05-30 2008-12-04 Japan As Represented By President Of National Cardiovascular Center Regeneration treatment apparatus, operating method thereof, and regeneration treatment method
CA2699642A1 (en) 2007-09-12 2009-03-19 The Regents Of The University Of California Compositions and methods for improving the functional efficacy of stem cell-derived cardiomyocytes
ES2530995T3 (es) 2007-09-28 2015-03-09 Anthrogenesis Corp Supresión de tumor usando perfusato placentario humano y células asesinas naturales intermediarias que provienen de placenta humana
US9962409B2 (en) * 2007-10-01 2018-05-08 Vestion, Inc. Therapy using cardiac stem cells and mesenchymal stem cells
WO2009046346A2 (en) 2007-10-04 2009-04-09 Medistem Laboratories, Inc. Stem cell therapy for weight loss
EP2210608B1 (en) 2007-11-02 2016-08-31 JCR Pharmaceuticals CO., LTD. Pharmaceutical composition containing human mesenchymal stem cell
EP2219656A2 (en) * 2007-11-09 2010-08-25 New York Medical College Methods for the repair and/or regeneration of damaged myocardium using variants of hepatocyte growth factor
EP2229177A1 (en) * 2007-11-30 2010-09-22 New York Medical College Methods of isolating non-senescent cardiac stem cells and uses thereof
US8512696B2 (en) 2007-11-30 2013-08-20 Autologous, Llc Methods of isolating non-senescent cardiac stem cells and uses thereof
CA2743698A1 (en) 2007-11-30 2009-06-11 New York Medical College Compositions comprising vascular and myocyte progenitor cells and methods of their use
AU2008334036B2 (en) 2007-11-30 2014-05-29 New York Medical College Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells
EP2245140A2 (en) * 2007-11-30 2010-11-03 New York Medical College Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure
US20100272679A1 (en) 2007-12-14 2010-10-28 Penn Marc S Compositions and methods of promoting wound healing
WO2009089476A1 (en) * 2008-01-11 2009-07-16 Kardia Therapeutics, Inc. Adult human cardiac-derived progenitor cells
CN105400735A (zh) * 2008-01-30 2016-03-16 阿斯特利亚斯生物治疗股份公司 用于培养干细胞衍生的心肌细胞的合成表面
US20110143433A1 (en) * 2008-03-17 2011-06-16 Agency For Science, Technology And Research Microcarriers for Stem Cell Culture
US8828720B2 (en) * 2008-03-17 2014-09-09 Agency For Science, Technology And Research Microcarriers for stem cell culture
US9458431B2 (en) 2008-03-17 2016-10-04 Agency For Science, Technology And Research Microcarriers for stem cell culture
US8716018B2 (en) 2008-03-17 2014-05-06 Agency For Science, Technology And Research Microcarriers for stem cell culture
US8691569B2 (en) * 2008-03-17 2014-04-08 Agency For Science, Technology And Research Microcarriers for stem cell culture
WO2009145761A1 (en) 2008-05-27 2009-12-03 Mayo Foundation For Medical Education And Research Methods and materials for using cells to treat heart tissue
US10035834B2 (en) * 2008-06-18 2018-07-31 The Texas A&M University System Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage
WO2010012127A1 (zh) * 2008-07-29 2010-02-04 河北以岭医药研究院有限公司 一种中药组合物在制备促进骨髓间质干细胞在体存活和成心肌分化的药物中的应用
AU2009281809B2 (en) * 2008-08-14 2015-09-17 Mesoblast International Sarl Purified mesenchymal stem cell compositions and methods of purifying mesenchymal stem cell compositions
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
NZ591292A (en) 2008-08-20 2012-10-26 Anthrogenesis Corp Improved cell composition and methods of making the same
EP2329012B1 (en) 2008-08-20 2020-05-20 Celularity, Inc. Treatment of stroke using isolated placental cells
CA2734446C (en) 2008-08-22 2017-06-20 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
JP5869342B2 (ja) 2008-11-19 2016-02-24 アンスロジェネシス コーポレーション 羊膜由来接着細胞
US8309343B2 (en) 2008-12-01 2012-11-13 Baxter International Inc. Apparatus and method for processing biological material
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
ES2665883T3 (es) 2008-12-19 2018-04-30 DePuy Synthes Products, Inc. Tratamiento de enfermedades y trastornos pulmonares y pulmonares
WO2010101962A1 (en) * 2009-03-02 2010-09-10 The Children's Mercy Hospital Tissue engineered human pulmonary valves with cyclic pressure bioreactor accelerated seeding strategies and methods for assessing inflammatory potential of putative scaffolds for tissue engineered heart valves
WO2010107392A1 (en) 2009-03-20 2010-09-23 Agency For Science, Technology And Research Culture of pluripotent and multipotent cells on microcarriers
EP2411504B1 (en) 2009-03-26 2017-05-10 DePuy Synthes Products, Inc. Human umbilical cord tissue cells as therapy for alzheimer's disease
US9301975B2 (en) 2009-05-01 2016-04-05 Biocardia, Inc. Method of preparing autologous cells and method of use for therapy
JP5917392B2 (ja) * 2009-05-01 2016-05-11 ビミニ テクノロジーズ リミテッド ライアビリティ カンパニー 組織及び細胞富化グラフトを最適化するシステム、方法及び組成物
EP2258833B1 (en) 2009-05-29 2014-03-12 Virga Jesse Hospital Isolation of a new cardiac stem cell population
CA2768576C (en) * 2009-07-21 2022-12-06 Abt Holding Company Use of stem cells to reduce leukocyte extravasation
AU2010303469A1 (en) * 2009-10-06 2012-05-03 The Cohen Mcniece Foundation Preparation and use of stromal cells for treatment of cardiac diseases
AU2010324536B2 (en) 2009-11-27 2016-03-03 Stephen Anthony Livesey A method of inducing cellular growth and materials for use therewith
CN102725399B (zh) 2009-12-18 2015-03-11 上海赛傲生物技术有限公司 制备多能干细胞的材料和方法
EP3284818B1 (en) 2010-01-26 2022-03-09 Celularity Inc. Treatment of bone-related cancers using placental stem cells
TW202011974A (zh) 2010-04-07 2020-04-01 美商安瑟吉納西斯公司 利用胎盤幹細胞之血管新生
TW201138792A (en) 2010-04-08 2011-11-16 Anthrogenesis Corp Treatment of sarcoidosis using placental stem cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
DK2568991T6 (da) 2010-05-12 2019-03-18 Abt Holding Co Modulation af splenocyter i celleterapi
WO2012009422A1 (en) 2010-07-13 2012-01-19 Anthrogenesis Corporation Methods of generating natural killer cells
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
AR093183A1 (es) 2010-12-31 2015-05-27 Anthrogenesis Corp Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras
KR20240042159A (ko) 2011-02-14 2024-04-01 미메딕스 그룹 인크. 마이크로화된 태반 조직 조성물 및 이의 제조 및 사용 방법
TWI602570B (zh) 2011-06-01 2017-10-21 安瑟吉納西斯公司 使用胎盤幹細胞之疼痛治療
WO2013055476A1 (en) 2011-09-09 2013-04-18 Anthrogenesis Corporation Treatment of amyotrophic lateral sclerosis using placental stem cells
EP2780020A4 (en) * 2011-11-14 2016-03-02 Regenerative Sciences Llc SUSPENDED PARTICLE DISTRIBUTION SYSTEMS AND METHODS
AU2012358810B2 (en) 2011-12-23 2018-03-15 DePuy Synthes Products, Inc. Detection of human umbilical cord tissue-derived cells
US10041039B2 (en) 2012-03-29 2018-08-07 Jcr Pharmaceuticals Co., Ltd. Method for producing pluripotent stem cells derived from dental pulp
EP2861238A4 (en) 2012-06-05 2016-03-16 Capricor Inc OPTIMIZED METHODS FOR GENERATING CARDIAC STEM CELLS FROM CARDIAC TISSUE AND THEIR USE IN CARDIAC THERAPY
CA2880811C (en) 2012-08-01 2021-12-07 United Therapeutics Corporation Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells
WO2014022373A1 (en) 2012-08-01 2014-02-06 United Therapeutics Corporation Treatment of pulmonary arterial hypertension with mesenchymal stem cells
EP2882445B1 (en) 2012-08-13 2019-04-24 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
US10857266B2 (en) 2012-08-15 2020-12-08 Mimedx Group, Inc. Reinforced placental tissue grafts and methods of making and using the same
US9943551B2 (en) 2012-08-15 2018-04-17 Mimedx Group, Inc. Tissue grafts composed of micronized placental tissue and methods of making and using the same
US8904664B2 (en) 2012-08-15 2014-12-09 Mimedx Group, Inc. Dehydration device and methods for drying biological materials
WO2014027474A1 (ja) 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞
US20140065110A1 (en) 2012-08-31 2014-03-06 The Regents Of The University Of California Genetically modified msc and therapeutic methods
US9663564B2 (en) 2013-03-15 2017-05-30 The Regents Of The University Of California Vectors and methods to treat ischemia
US9180145B2 (en) 2012-10-12 2015-11-10 Mimedx Group, Inc. Compositions and methods for recruiting and localizing stem cells
US8946163B2 (en) 2012-11-19 2015-02-03 Mimedx Group, Inc. Cross-linked collagen comprising metallic anticancer agents
JP7042017B2 (ja) 2012-11-30 2022-03-29 ヴェッション，インコーポレーテッド 心臓幹細胞、ならびに該細胞を同定し、そして用いる方法
EP3878452B1 (en) * 2013-01-09 2023-09-20 United Therapeutics Corporation Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
US10206977B1 (en) 2013-01-18 2019-02-19 Mimedx Group, Inc. Isolated placental stem cell recruiting factors
US9662355B2 (en) 2013-01-18 2017-05-30 Mimedx Group, Inc. Methods for treating cardiac conditions
WO2014123879A1 (en) 2013-02-05 2014-08-14 Anthrogenesis Corporation Natural killer cells from placenta
JP6571537B2 (ja) 2013-03-13 2019-09-04 ザ ユニバーシティー オブ クイーンズランド 療法および予防のための細胞を単離する方法
US10029030B2 (en) 2013-03-15 2018-07-24 Mimedx Group, Inc. Molded placental tissue compositions and methods of making and using the same
PL2983680T3 (pl) 2013-04-12 2021-03-08 Houston Methodist Hospital Ulepszanie narządów do przeszczepu
EP4218779A1 (en) * 2013-05-22 2023-08-02 National Center Of Neurology And Psychiatry Stem cells for transplantation and manufacturing method therefor
JP2016537414A (ja) 2013-10-29 2016-12-01 ベスティオン、インク． 心臓神経堤細胞、及びその使用方法
CN105992816B (zh) 2013-11-16 2018-04-17 泰尔茂比司特公司 生物反应器中的细胞扩增
US10087436B2 (en) 2014-02-06 2018-10-02 The Regents Of The University Of California Electrophysiologically mature cardiomyocytes and methods for making same
WO2015140005A1 (en) 2014-03-19 2015-09-24 Ifom Fondazione Istituto Firc Di Oncologia Molecolare Method of generation of pluripotent cells
EP3613841B1 (en) 2014-03-25 2022-04-20 Terumo BCT, Inc. Passive replacement of media
KR102311902B1 (ko) 2014-05-12 2021-10-13 루스터바이오, 인크. 바로 프린트할 수 있는 세포 및 통합 장치
US10918669B2 (en) 2014-07-25 2021-02-16 Recellerate, Inc. Methods of treating exercise-induced pulmonary hemorrhage
US10617785B2 (en) 2014-08-28 2020-04-14 Mimedx Group, Inc. Collagen reinforced tissue grafts
JP6830059B2 (ja) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド スケジュール化された細胞フィーディング
AU2015327812B2 (en) 2014-10-03 2021-04-15 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
BR112017012911B1 (pt) * 2014-12-23 2021-10-05 Mesoblast International Sàrl Método para tratamento de insuficiência cardíaca
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
WO2017205667A1 (en) 2016-05-25 2017-11-30 Terumo Bct, Inc. Cell expansion
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
EP3515459A4 (en) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS
WO2018080990A1 (en) 2016-10-24 2018-05-03 United Therapeutics Corporation Enhancement of msc immunomodulatory properties by treprostinil
CN109952371A (zh) 2016-11-15 2019-06-28 株式会社钟化 包含来自胎儿附属物的间充质系干细胞的细胞群、其制备方法、以及医药组合物
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
CN117247899A (zh) 2017-03-31 2023-12-19 泰尔茂比司特公司 细胞扩增
JP7336769B2 (ja) 2017-04-19 2023-09-01 シーダーズ―シナイ メディカル センター 骨格筋ジストロフィーを治療する方法及び組成物
WO2019079195A1 (en) 2017-10-16 2019-04-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education GENETICALLY MODIFIED MESENCHYMAL STEM CELLS FOR USE IN CARDIOVASCULAR PROSTHESES
WO2019126068A1 (en) 2017-12-20 2019-06-27 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
JP7454379B2 (ja) 2017-12-28 2024-03-22 株式会社カネカ 接着性幹細胞を含む細胞集団とその製造方法、及び医薬組成物
IL280387B1 (en) 2018-07-31 2024-03-01 Japan Chem Res A method for producing cells derived from dental pulp
AU2019335614A1 (en) * 2018-09-06 2021-04-08 Technion Research And Development Foundation Limited Tissue repair by activated cells
EP3984596A4 (en) 2019-06-14 2023-06-21 Kaneka Corporation POPULATION OF CELLS COMPRISING MESENCHYMATOUS CELLS, PHARMACEUTICAL COMPOSITION COMPRISING THEM AND METHOD FOR PRODUCTION THEREOF
JPWO2021153719A1 (da) 2020-01-30 2021-08-05

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5591625A (en) 1993-11-24 1997-01-07 Case Western Reserve University Transduced mesenchymal stem cells
WO1996039035A1 (en) * 1995-06-06 1996-12-12 Case Western Reserve University Myogenic differentiation of human mesenchymal stem cells
AU6836596A (en) * 1995-09-08 1997-03-27 Takara Shuzo Co., Ltd. Transformant
US6099832A (en) 1997-05-28 2000-08-08 Genzyme Corporation Transplants for myocardial scars

Also Published As

Publication number Publication date
EP1007631B1 (en) 2005-10-19
CA2296704A1 (en) 1999-01-28
ES2251773T5 (es) 2009-05-12
DE69831957D1 (de) 2006-03-02
EP1007631A1 (en) 2000-06-14
US6387369B1 (en) 2002-05-14
EP1007631B2 (en) 2009-02-18
JP2002511094A (ja) 2002-04-09
DE69831957T3 (de) 2009-07-23
WO1999003973A1 (en) 1999-01-28
ATE307195T1 (de) 2005-11-15
DE69831957T2 (de) 2006-07-27
JP4562816B2 (ja) 2010-10-13
CA2296704C (en) 2010-10-19
EP1007631A4 (en) 2003-05-21
ES2251773T3 (es) 2006-05-01
AU8401498A (en) 1999-02-10
DK1007631T3 (da) 2006-03-06

Similar Documents

Publication Publication Date Title
DK1007631T4 (da) Hjertemuskelregeneration ved anvendelse af mesenkymale stamceller
WO2004037188A3 (en) Cardiac muscle regeneration using mesenchymal stem cells
US5827740A (en) Adipogenic differentiation of human mesenchymal stem cells
Taylor et al. Multiple new phenotypes induced in 10T12 and 3T3 cells treated with 5-azacytidine
Russell et al. Conversion of 3T3 fibroblasts into adipose cells: triggering of differentiation by prostaglandin F2alpha and 1-methyl-3-isobutyl xanthine.
Abe et al. High cell density alters the ratio of type III to I collagen synthesis by fibroblasts
GB2427873A (en) Method for making high purity cardiomyocyte preparations suitable for regenerative medicine
US20150104431A1 (en) Cardiac muscle repair or regeneration using bone marrow-derived stem cells
CA2339182A1 (en) Improvement of cardiac function by mesenchymal stem cell transplantation
ATE358493T1 (de) Menschliche mesenchymale stammzellen aus peripherem blut
WO1999049015A3 (en) Cardiac-derived stem cells
Lancaster et al. An electrically coupled tissue-engineered cardiomyocyte scaffold improves cardiac function in rats with chronic heart failure
CN108685934B (zh) 京尼平苷在促进骨骼肌快肌生成中的应用
HIRANO et al. Bone-forming and bone-resorbing cell lines derived from bone marrow in tissue culture
Makowka et al. Allogeneic hepatocyte transplantation in the rat spleen under cyclosporine immunosuppression
Gojo et al. Plasticity of Mesenchymal Stem Cells‐Regenerative Medicine for Diseased Hearts‐
EP1429716B1 (en) Cosmetic preparation with anti-wrinkle action
Limas et al. Alkaline phosphatase in vascular smooth muscle
Pitaru et al. The effect of age on the expression of mineralized tissue progenitors in the periodontium--the effect of bFGF.
Ledet et al. Insulin, ketones, glucose and glucagon
AU2003234740B2 (en) Adipogenic Differentiation of Human Mesenchymal Stem Cells
Niesler Old dogmas and new hearts: a role for adult stem cells in cardiac repair?
Prasad Effect of sodium butyrate in combination with X0irradiation, chemotherapeutic and cyclic AMP stimulating agents on neuroblastoma cells in culture
Hopgood et al. Regulation of protein breakdown in hepatocyte monolayers
Binderman et al. Growth Induction of bone and cartilage cells by physical forces