JP2002511094A - 間葉幹細胞を用いる心筋再生 - Google Patents
間葉幹細胞を用いる心筋再生Info
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- JP2002511094A JP2002511094A JP50760299A JP50760299A JP2002511094A JP 2002511094 A JP2002511094 A JP 2002511094A JP 50760299 A JP50760299 A JP 50760299A JP 50760299 A JP50760299 A JP 50760299A JP 2002511094 A JP2002511094 A JP 2002511094A
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- mesenchymal stem
- stem cells
- cells
- heart
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Cardiology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.一つの個体の心臓に間葉幹細胞の心筋細胞産生量を投与することよりなりそ れを必要とする心臓に心筋細胞を産生するための一つの方法。 2.請求の範囲第1項に記載の方法であって、ここで間葉幹細胞が心臓組織の少 なくとも1個の損傷部分に直接投与されることを特徴とする方法。 3.請求の範囲第2項に記載の方法であって、ここで間葉幹細胞が注射により投 与されることを特徴とする方法。 4.請求の範囲第3項に記載の方法であって、ここで間葉幹細胞が薬理許容液注 射可能担体で投与されることを特徴とする方法。 5.請求の範囲第2項に記載の方法であって、ここで間葉幹細胞が開腹手術手順 の間に投与されることを特徴とする方法。 6.請求の範囲第5項に記載の方法であって、ここで間葉幹細胞が注射により投 与されることを特徴とする方法。 7.請求の範囲第6項に記載の方法であって、ここで間葉幹細胞が液状形態で注 射可能でありまた損傷した心筋細胞の部位で半固形になる生物適合性媒質で投与 されることを特徴とする方法。 8.請求の範囲第7項に記載の方法であって、ここで媒質がコラーゲンおよびそ の誘導体、ポリ乳酸、ポリグリコール酸および細胞外基質よりなるグループから 選択されることを特徴とする方法。 9.請求の範囲第5項に記載の方法であって、ここで間葉幹細 胞が固形の可撓性基質である生物適合性媒質で投与されることを特徴とする方法 。 10.請求の範囲第9項に記載の方法であって、ここで固形可撓付基質が開腹手 術手順の間に心臓の少なくとも1個の損傷部分に適用されることを特徴とする方 法。 11.請求の範囲第9項に記載の方法であって、ここで固形可撓性基質が半固形 生物適合性媒質に含浸される1個もしくはそれ以上の線維層を含むことを特徴と する方法。 12.請求の範囲第1項に記載の方法であって、ここで間葉幹細胞がヒトである ことを特徴とする方法。 13.請求の範囲第12項に記載の方法であって、ここで間葉幹細胞が治療され る個体に自己由来であることを特徴とする方法。 14.請求の範囲第1項に記載の方法であって、ここで少なくとも一部の間葉幹 細胞が外因性遺伝子物質を含むように修飾されていることを特徴とする方法。 15.請求の範囲第14項に記載の方法であって、ここで外因性遺伝子物質が成 長因子、筋原性因子、転写因子、サイトカイン、ホメオボックス遺伝子、血管形 成刺激因子および血管再生強化因子よりなるグループから選択される発現産物を コード化することを特徴とする方法。 16.間葉幹細胞を含む一つの組成物であって、その少なくとも一部が成長因子 、筋原性因子、転写因子、サイトカイン、ホメオボックス遺伝子、血管形成刺激 因子および血管再生強化因子よりなるグループから選択される発現産物をコード 化する外 因性遺伝子物質を含むように修飾されている組成物。 17.請求の範囲第16項に記載の組成物であって、ここで間葉幹細胞がヒトで あることを特徴とする組成物。 18.請求の範囲第16項に記載の組成物であって、ここで間葉幹細胞が自己由 来であることを特徴とする組成物。 19.心筋細胞を必要とする個体の心臓に心筋細胞を産生する一つの方法であっ て、心筋細胞に分化するために試験管内で誘導された間葉幹細胞をその心臓に投 与することを含む方法。 20.個体の心臓組織に心筋細胞を産生する一つの組成物の調製のためのヒト間 葉幹細胞の使用。 21.受容体の心臓に移植される心臓弁に細胞を再植民する一つの方法であって 、この心臓弁を間葉幹細胞に生体外で接触させ、ここで間葉幹細胞が弁に浸潤し 再植民することを含む方法。 22.梗塞を起こした心臓組織の瘢痕形成を少なくする一つの方法であって、梗 塞組織に間葉幹細胞の心筋細胞産生量を投与することを含む方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5291097P | 1997-07-14 | 1997-07-14 | |
US60/052,910 | 1997-07-14 | ||
PCT/US1998/014520 WO1999003973A1 (en) | 1997-07-14 | 1998-07-14 | Cardiac muscle regeneration using mesenchymal stem cells |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2002511094A true JP2002511094A (ja) | 2002-04-09 |
JP2002511094A5 JP2002511094A5 (ja) | 2006-01-05 |
JP4562816B2 JP4562816B2 (ja) | 2010-10-13 |
Family
ID=21980718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50760299A Expired - Lifetime JP4562816B2 (ja) | 1997-07-14 | 1998-07-14 | 心筋再生のための間葉幹細胞の使用法および組成物 |
Country Status (10)
Country | Link |
---|---|
US (1) | US6387369B1 (ja) |
EP (1) | EP1007631B2 (ja) |
JP (1) | JP4562816B2 (ja) |
AT (1) | ATE307195T1 (ja) |
AU (1) | AU8401498A (ja) |
CA (1) | CA2296704C (ja) |
DE (1) | DE69831957T3 (ja) |
DK (1) | DK1007631T4 (ja) |
ES (1) | ES2251773T5 (ja) |
WO (1) | WO1999003973A1 (ja) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002521493A (ja) * | 1998-07-31 | 2002-07-16 | ジェンザイム コーポレーション | 間葉幹細胞移植による心機能の改善 |
JP2006521121A (ja) * | 2003-03-28 | 2006-09-21 | アンジオブラスト・システムズ・インコーポレーテッド | 血管周囲の間葉系前駆細胞に誘導される血管形成 |
JP2007517036A (ja) * | 2003-12-24 | 2007-06-28 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | 房室ブロックを補うための生物学的房室間バイパスの作製 |
JP2011521645A (ja) * | 2008-05-27 | 2011-07-28 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 心臓組織治療用細胞組成物及び方法 |
WO2014027474A1 (ja) * | 2012-08-17 | 2014-02-20 | 株式会社Clio | 心筋梗塞の修復再生を誘導する多能性幹細胞 |
US8962320B2 (en) | 2004-07-30 | 2015-02-24 | Mayo Foundation For Medical Education And Research | Treating cardiovascular tissue |
JPWO2014189071A1 (ja) * | 2013-05-22 | 2017-02-23 | 国立研究開発法人国立精神・神経医療研究センター | 移植用幹細胞及びその製造方法 |
US9765298B2 (en) | 2006-07-24 | 2017-09-19 | Mayo Foundation For Medical Education And Research | Methods and materials for providing cardiac cells |
WO2018092769A1 (ja) | 2016-11-15 | 2018-05-24 | 株式会社カネカ | 胎児付属物に由来する間葉系幹細胞を含む細胞集団とその製造方法、及び医薬組成物 |
WO2019132026A1 (ja) | 2017-12-28 | 2019-07-04 | 株式会社カネカ | 接着性幹細胞を含む細胞集団とその製造方法、及び医薬組成物 |
WO2020251020A1 (ja) | 2019-06-14 | 2020-12-17 | 株式会社カネカ | 間葉系細胞を含む細胞集団、それを含む医薬組成物、及び、その製造方法 |
Families Citing this family (254)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6974571B2 (en) * | 1995-03-28 | 2005-12-13 | Thomas Jefferson University | Isolated stromal cells and methods of using the same |
US20030103951A1 (en) * | 1997-07-14 | 2003-06-05 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
US7514074B2 (en) | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
WO1999046366A1 (en) * | 1998-03-13 | 1999-09-16 | Osiris Therapeutics, Inc. | Uses for humane non-autologous mesenchymal stem cells |
EP1894997A1 (en) * | 1998-07-31 | 2008-03-05 | Genzyme Corporation | Improvement of cardiac function by mesenchymal stem cell transplantation |
AU6056299A (en) * | 1998-09-21 | 2000-04-10 | Musc Foundation For Research Development | Non-hematopoietic cells, including cardiomyocytes and skeletal muscle cells, derived from hematopoietic stem cells and methods of making and using them |
US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
US6777231B1 (en) | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
US20030082152A1 (en) | 1999-03-10 | 2003-05-01 | Hedrick Marc H. | Adipose-derived stem cells and lattices |
US6635249B1 (en) * | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
US20050158289A1 (en) * | 1999-07-07 | 2005-07-21 | Simmons Paul J. | Mesenchymal precursor cell and use thereof in the repair of bone defects and fractures in mammals |
US8062675B2 (en) | 1999-07-07 | 2011-11-22 | Angioblast Systems, Inc. | Mesenchymal precursor cell |
US7670628B2 (en) * | 1999-07-07 | 2010-03-02 | Angioblast Systems, Inc. | Mesenchymal precursor cell |
AUPQ147799A0 (en) * | 1999-07-07 | 1999-07-29 | Medvet Science Pty. Ltd. | Mesenchymal precursor cell |
US7015037B1 (en) * | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
US8252280B1 (en) | 1999-08-05 | 2012-08-28 | Regents Of The University Of Minnesota | MAPC generation of muscle |
US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
US8075881B2 (en) * | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
EP1903107A1 (en) * | 1999-09-24 | 2008-03-26 | Cybios LLC | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof |
EP1221956A2 (en) * | 1999-09-30 | 2002-07-17 | McGILL UNIVERSITY | Autologous marrow stem cell (msc) transplantation for myocardial regeneration |
EP1254952A4 (en) * | 1999-12-28 | 2004-09-22 | Kyowa Hakko Kogyo Kk | CELLS WHICH CAN INDUCE DIFFERENTIATION IN CARDIAC MUSCLE CELLS |
US20100303769A1 (en) * | 2000-04-06 | 2010-12-02 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease |
US7166280B2 (en) * | 2000-04-06 | 2007-01-23 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease |
US20110091428A1 (en) * | 2000-07-31 | 2011-04-21 | New York Medical College | Compositions of adult organ stem cells and uses thereof |
US7862810B2 (en) * | 2000-07-31 | 2011-01-04 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
AU2001284695A1 (en) * | 2000-07-31 | 2002-02-13 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
US7214371B1 (en) | 2000-09-01 | 2007-05-08 | Ben-Gurion University Of The Negev Research & Development Authority | Tissue engineered biografts for repair of damaged myocardium |
US7560280B2 (en) * | 2000-11-03 | 2009-07-14 | Kourion Therapeutics Gmbh | Human cord blood derived unrestricted somatic stem cells (USSC) |
DE10056465A1 (de) * | 2000-11-14 | 2002-07-18 | Rosemarie Daig | Zellkonstrukte erhältlich aus mesenchymalen Stammzellen und davon ableitbaren Zellen und ihre Verwendung |
US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
CA2678490A1 (en) | 2000-12-06 | 2002-06-13 | Robert J. Hariri | Isolated placental perfusate and placental cells isolated therefrom |
WO2002064157A2 (en) * | 2001-01-23 | 2002-08-22 | Boston Scientific Corporation | Localized myocardial injection method for treating ischemic myocardium |
JP2004528021A (ja) * | 2001-02-14 | 2004-09-16 | アンスロジェネシス コーポレーション | 分娩後の哺乳動物の胎盤、その使用およびそれに由来する胎盤幹細胞 |
KR101132545B1 (ko) * | 2001-02-14 | 2012-04-02 | 안트로제네시스 코포레이션 | 산후 포유류의 태반, 이의 용도 및 태반 줄기세포 |
WO2002084281A1 (en) | 2001-04-13 | 2002-10-24 | Anterogen Co., Ltd. | Encapsulated cell indicator system |
US7732199B2 (en) | 2001-07-12 | 2010-06-08 | Geron Corporation | Process for making transplantable cardiomyocytes from human embryonic stem cells |
CN1543500B (zh) * | 2001-07-12 | 2014-04-09 | 杰龙公司 | 从人多能干细胞产生心肌细胞系细胞 |
ITRM20010550A1 (it) * | 2001-09-11 | 2003-03-11 | Giulio Cossu | Metodo per indurre il differenziamento di cellule endoteliali in cardiomiociti. |
CA2465672A1 (en) * | 2001-09-19 | 2003-03-27 | Henry Ford Health System | Cardiac transplantation of stem cells for the treatment of heart failure |
US20030082153A1 (en) | 2001-10-22 | 2003-05-01 | The Government Of The United States Of America | Stem cells that transform to beating cardiomyocytes |
CN1612691A (zh) * | 2001-11-08 | 2005-05-04 | 加利福尼亚大学董事会 | 纠正心脏传导障碍的方法和组合物 |
KR101083454B1 (ko) | 2001-12-07 | 2011-11-16 | 사이토리 테라퓨틱스, 인크. | 처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한 시스템 및 방법 |
US7651684B2 (en) | 2001-12-07 | 2010-01-26 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in augmenting autologous fat transfer |
US20050095228A1 (en) | 2001-12-07 | 2005-05-05 | Fraser John K. | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
US8404229B2 (en) | 2001-12-07 | 2013-03-26 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to treat acute tubular necrosis |
US7771716B2 (en) * | 2001-12-07 | 2010-08-10 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
US7514075B2 (en) | 2001-12-07 | 2009-04-07 | Cytori Therapeutics, Inc. | Systems and methods for separating and concentrating adipose derived stem cells from tissue |
US7595043B2 (en) | 2001-12-07 | 2009-09-29 | Cytori Therapeutics, Inc. | Method for processing and using adipose-derived stem cells |
US7585670B2 (en) | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
US9597395B2 (en) * | 2001-12-07 | 2017-03-21 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
US8105580B2 (en) | 2001-12-07 | 2012-01-31 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to promote wound healing |
AU2002226683A1 (en) * | 2002-01-17 | 2003-07-30 | Cardio Incorporated | Complex therapy for tissue regeneration |
WO2003073998A2 (en) * | 2002-03-02 | 2003-09-12 | Board Of Regents, The University Of Texas System | Local production and/or delivery of anti-cancer agents by stromal cell precursors |
WO2003093433A2 (en) | 2002-05-02 | 2003-11-13 | Regents Of The University Of Minnesota | Fibrin-based biomatrix |
WO2003094697A2 (en) * | 2002-05-08 | 2003-11-20 | The Regents Of The University Of California | Methods and compositions for correction of cardiac conduction disturbances |
US20040067221A1 (en) * | 2002-05-22 | 2004-04-08 | Medtronic, Inc. | Cell delivery fluid for prevention of cell settling in delivery system |
AU2003259152A1 (en) * | 2002-07-23 | 2004-02-09 | Boston Scientific Limited | Cell therapy for regeneration |
US20050271639A1 (en) * | 2002-08-22 | 2005-12-08 | Penn Marc S | Genetically engineered cells for therapeutic applications |
AR047712A1 (es) * | 2002-09-07 | 2006-02-15 | Royal Veterinary College | Metodo de tratamiento de una lesion de tejido esqueletico blando natural administrando una composicion de celulas madre mesenquimatosas |
JP2006505380A (ja) * | 2002-11-05 | 2006-02-16 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 間葉幹細胞およびその使用方法 |
US7470538B2 (en) * | 2002-12-05 | 2008-12-30 | Case Western Reserve University | Cell-based therapies for ischemia |
US20040258670A1 (en) * | 2002-12-05 | 2004-12-23 | Case Western Reserve University | Cell-based therapies for ischemia |
US7794702B2 (en) * | 2003-01-15 | 2010-09-14 | The Trustees Of Columbia University In The City Of New York | Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures |
US20050002914A1 (en) * | 2003-01-15 | 2005-01-06 | Rosen Michael R. | Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures |
US20040197310A1 (en) * | 2003-02-12 | 2004-10-07 | Sanberg Paul R. | Compositions and methods for using umbilical cord progenitor cells in the treatment of myocardial infarction |
AU2011253681B2 (en) * | 2003-03-28 | 2014-04-10 | Mesoblast, Inc. | Perivascular mesenchymal precursor cell induced blood vessel formation |
CA2521217C (en) * | 2003-04-01 | 2013-05-14 | United States Of America Department Of Veteran's Affairs | Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction |
US20040213770A1 (en) * | 2003-04-22 | 2004-10-28 | Endobionics, Inc. | Methods and systems for treating ischemic cardiac and other tissues |
WO2004110270A1 (en) * | 2003-06-12 | 2004-12-23 | Regents Of The University Of Minnesota | Directing cells to target tissues or organs |
US8367410B2 (en) * | 2003-06-20 | 2013-02-05 | Massachusetts Institute Of Technology | Application of electrical stimulation for functional tissue engineering in vitro and in vivo |
NZ544828A (en) * | 2003-06-25 | 2008-10-31 | Ottawa Health Research Inst | Use of cardiotrophin to modulate stem cell proliferation |
PL1649013T3 (pl) | 2003-06-27 | 2016-07-29 | Depuy Synthes Products Inc | Regeneracja i naprawa chrząstki i kości z wykorzystaniem komórek poporodowych |
US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
US20050013870A1 (en) * | 2003-07-17 | 2005-01-20 | Toby Freyman | Decellularized extracellular matrix of conditioned body tissues and uses thereof |
ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
CA2443423A1 (en) * | 2003-09-30 | 2005-03-30 | Darren H. Freed | Use of cardiotrophon-1 to promote wound healing and counteract overt fibrosis |
WO2005042723A2 (en) * | 2003-10-28 | 2005-05-12 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | Novel multipotent stem cells and use thereof |
US7840263B2 (en) * | 2004-02-27 | 2010-11-23 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression |
US20050214938A1 (en) * | 2004-03-26 | 2005-09-29 | Gold Joseph D | Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function |
US7452718B2 (en) * | 2004-03-26 | 2008-11-18 | Geron Corporation | Direct differentiation method for making cardiomyocytes from human embryonic stem cells |
DE602005017877D1 (de) * | 2004-03-30 | 2010-01-07 | Boston Scient Ltd | Restenose-therapie mit mesenchym-stammzellen |
WO2005099758A2 (en) * | 2004-04-17 | 2005-10-27 | The Board Of Trustees The Leland Standford Junior University | Injectable bioartificial tissue matrix |
JP2007536935A (ja) * | 2004-05-14 | 2007-12-20 | ベクトン・ディキンソン・アンド・カンパニー | 間葉幹細胞の無血清増殖のための細胞培養環境 |
US20050277124A1 (en) * | 2004-06-10 | 2005-12-15 | White Steven M | Cardiac conduction system cells and uses thereof |
CA2571315C (en) * | 2004-06-21 | 2017-02-14 | The Cleveland Clinic Foundation | Ccr ligands for stem cell homing |
JP2008506416A (ja) * | 2004-07-19 | 2008-03-06 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | 遺伝子組み換えされた細胞が合胞体の機能を変える効果を監視するための分析システム |
US7828711B2 (en) * | 2004-08-16 | 2010-11-09 | Cardiac Pacemakers, Inc. | Method and apparatus for modulating cellular growth and regeneration using ventricular assist device |
US8513011B2 (en) * | 2004-08-26 | 2013-08-20 | Biotech Research Ventures Pte Limited | Methods and compositions for culturing cardiomyocyte-like cells |
US7785582B2 (en) * | 2004-09-07 | 2010-08-31 | Johnson Lanny L | Use of synovium and omentum for tissue engineering |
US8182806B2 (en) * | 2004-09-07 | 2012-05-22 | Johnson Lanny L | Synovial villi for use with tissue engineering |
US20060051328A1 (en) * | 2004-09-07 | 2006-03-09 | Johnson Lanny L | Mobilization of cells via physical means |
KR20070085288A (ko) | 2004-09-24 | 2007-08-27 | 안지오블라스트 시스템스 인코퍼레이티드 | 간엽 전구세포의 증식 및/또는 생존성 증강 방법 |
US20070072294A1 (en) * | 2004-09-30 | 2007-03-29 | Doronin Sergey V | Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division |
US20060234375A1 (en) * | 2004-09-30 | 2006-10-19 | Doronin Sergey V | Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division |
WO2006037103A2 (en) * | 2004-09-30 | 2006-04-06 | The Trustees Of Columbia University In The City Of New York | The use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division |
US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
US20080267921A1 (en) * | 2004-11-08 | 2008-10-30 | Johns Hopkins University | Cardiac Stem Cells |
US8060219B2 (en) | 2004-12-20 | 2011-11-15 | Cardiac Pacemakers, Inc. | Epicardial patch including isolated extracellular matrix with pacing electrodes |
US7981065B2 (en) | 2004-12-20 | 2011-07-19 | Cardiac Pacemakers, Inc. | Lead electrode incorporating extracellular matrix |
GB0428328D0 (en) * | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
CA2512667A1 (en) * | 2005-01-07 | 2006-07-07 | Takahiro Ochiya | Human hepatocyte-like cells and uses thereof |
US20060180187A1 (en) * | 2005-02-14 | 2006-08-17 | Squeegit, Inc. | Window cleaning apparatus |
US20060263338A1 (en) * | 2005-03-04 | 2006-11-23 | Jacoby Douglas B | Catheter-based delivery of Skeletal Myoblasts to the Myocardium of Damaged Hearts |
US20100028312A1 (en) * | 2005-03-24 | 2010-02-04 | Caritas St. Elizabeth Medical Center of Boston Inc | Stably transformed bone marrow-derived cells and uses thereof |
CN103356707B (zh) | 2005-03-31 | 2016-07-06 | 斯丹姆涅恩有限公司 | 制备用以治疗伤口或糖尿病性神经病引发的溃疡,或预防手术后疝形成的药物的方法 |
CA2608048A1 (en) * | 2005-05-10 | 2006-11-16 | United States Of America Department Of Veteran's Affairs | Therapy of kidney diseases and multiorgan failure with mesenchymal stem cells and mesenchymal stem cell conditioned media |
EP2465923B1 (en) * | 2005-05-25 | 2018-04-11 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
KR101529317B1 (ko) | 2005-06-22 | 2015-06-16 | 아스테리아스 바이오세라퓨틱스, 인크. | 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화 |
US8568761B2 (en) * | 2005-07-15 | 2013-10-29 | Cormatrix Cardiovascular, Inc. | Compositions for regenerating defective or absent myocardium |
US7531355B2 (en) | 2005-07-29 | 2009-05-12 | The Regents Of The University Of California | Methods and compositions for smooth muscle reconstruction |
US7927630B2 (en) * | 2005-09-12 | 2011-04-19 | Johnson Lanny L | Use of autologous sediment from fluid aspirates as vehicles for drug delivery |
US8518349B2 (en) | 2005-09-12 | 2013-08-27 | Lanny Johnson | Use of autologous sediment from fluid aspirates as vehicles for drug delivery |
PE20070771A1 (es) | 2005-10-13 | 2007-08-11 | Anthrogenesis Corp | Inmunomodulacion mediante el uso de celulas madres de la placenta |
US20090155220A1 (en) * | 2005-10-20 | 2009-06-18 | Caritas St. Elizabeth's Medical Center Of Boston | Use of Bone-Marrow Derived Stem Cells to Treat Ischemia |
EP2267114B1 (en) * | 2005-10-28 | 2014-03-12 | Universität Zürich | Tissue engineering using pure populations of isolated non-embryoblastic fetal cells |
US7713232B2 (en) | 2005-11-04 | 2010-05-11 | Medrad, Inc. | System for washing and processing of cells for delivery thereof to tissue |
US8182444B2 (en) * | 2005-11-04 | 2012-05-22 | Medrad, Inc. | Delivery of agents such as cells to tissue |
US10117900B2 (en) | 2005-11-09 | 2018-11-06 | Athersys, Inc. | MAPC treatment of brain injuries and diseases |
US11000546B2 (en) | 2005-11-09 | 2021-05-11 | Athersys, Inc. | Immunomodulatory properties of MAPCs and uses thereof |
CN101374946B (zh) | 2005-12-16 | 2017-07-18 | 伊西康公司 | 用于在组织相容性不匹配的移植中抑制有害的免疫反应的组合物和方法 |
US7534607B1 (en) | 2005-12-27 | 2009-05-19 | Industrial Technology Research Institute | Method of producing cardiomyocytes from mesenchymal stem cells |
US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
CN101389754A (zh) | 2005-12-29 | 2009-03-18 | 人类起源公司 | 胎盘干细胞和第二来源干细胞的联合培养 |
ES2708933T3 (es) | 2005-12-29 | 2019-04-12 | Celularity Inc | Poblaciones de células madre placentarias |
EP3345610A1 (en) | 2006-01-23 | 2018-07-11 | Athersys, Inc. | Mapc therapeutics without adjunctive immunosuppressive treatment |
US20070178137A1 (en) * | 2006-02-01 | 2007-08-02 | Toby Freyman | Local control of inflammation |
US8071380B2 (en) | 2006-02-16 | 2011-12-06 | Fondazione Centro San Raffaele Del Monte Tabor | Skeletal muscle periangioblasts and cardiac mesangioblasts, method for isolation and uses thereof |
ITPA20060008A1 (it) * | 2006-03-14 | 2007-09-15 | Luciano Ciuro | Sistema per impianto di cellule staminali intracardiaco secondo metodo ciuro; pseudonimo del sistema "spyder". |
US20070253937A1 (en) * | 2006-04-26 | 2007-11-01 | Young-Sup Yoon | Novel multipotent stem cells and use thereof |
WO2007139551A1 (en) * | 2006-05-30 | 2007-12-06 | Cytori Therapeutics, Inc. | Systems and methods for manipulation of regenerative cells from adipose tissue |
US20130122108A1 (en) * | 2006-06-06 | 2013-05-16 | Robert G Matheny | Compositions for Regenerating Defective or Absent Myocardium |
AU2007258514A1 (en) * | 2006-06-09 | 2007-12-21 | Anthrogenesis Corporation | Placental niche and use thereof to culture stem cells |
US20070293893A1 (en) * | 2006-06-14 | 2007-12-20 | Craig Stolen | Method and apparatus for preconditioning of cells |
WO2008013863A2 (en) * | 2006-07-26 | 2008-01-31 | Cytori Therapeutics, Inc. | Generation of adipose tissue and adipocytes |
US7993918B2 (en) * | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
US20090035286A1 (en) * | 2006-08-08 | 2009-02-05 | Minguell Jose J | Intracoronary, intracardiac, or intravenous infusion of a mixture of autologous bone marrow derived mononuclear cells and autologous bone marrow derived mesenchymal stem cells for utilization and rescue of infarcted myocardium |
US20080038229A1 (en) * | 2006-08-08 | 2008-02-14 | Minguell Jose J | Intracoronary injection of a mixture of autologous bone marrow derived mononuclear cells and autologous bone marrow derived mesenchymal stem cells for utilization and rescue of infarcted myocardium |
US20110044950A1 (en) * | 2006-08-08 | 2011-02-24 | Minguell Jose J | Infusion of a Mixture of Autologous Bone Marrow-Derived Mononuclear Cells and Autologous or Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells for Treating Myocardial and/or Cardiovascular Disorders |
WO2008040027A2 (en) * | 2006-09-28 | 2008-04-03 | The Regents Of The University Of California | Directed differentiation and maturation of stem cell-derived cardiomyocytes |
US20080086111A1 (en) * | 2006-10-09 | 2008-04-10 | Medrad, Inc. | Fluid delivery systems and volume metering in cell delivery |
WO2008054819A2 (en) * | 2006-11-02 | 2008-05-08 | The General Hospital Corporation | Cardiovascular stem cells, methods for stem cell isolation, and uses thereof |
DE602007012290D1 (de) | 2006-11-03 | 2011-03-10 | Aastrom Biosciences Inc | Mischzell-populationen für die gewebereparatur und trenntechnik für die zellaufbereitung |
EP2087098A4 (en) * | 2006-11-09 | 2010-03-31 | Univ Johns Hopkins | DEDIFFERENTIATION OF ADULT MAMMALIAN CARDIOMYCYTES INTO CARDIAC STEM CELLS |
CN101573442A (zh) * | 2006-11-09 | 2009-11-04 | J·大卫格莱斯顿学会 | 诱导心肌细胞形成的方法 |
WO2008085229A2 (en) * | 2006-11-15 | 2008-07-17 | Arteriocyte Inc. | Cell-based therapies for treating liver disease |
CA2670497A1 (en) * | 2006-11-24 | 2008-05-29 | Regents Of The University Of Minnesota | Endodermal progenitor cells |
RS52921B (en) | 2007-02-12 | 2014-02-28 | Anthrogenesis Corporation | TREATMENT OF INFLAMMATORY DISEASES USING PLACENTAL CELL CELLS |
ATE530638T1 (de) | 2007-04-26 | 2011-11-15 | Univ Ramot | Pluripotente autologe stammzellen aus der mündlichen oder gastrointestinalen schleimhaut |
TWM322542U (en) * | 2007-05-23 | 2007-11-21 | Universal Scient Ind Co Ltd | Testing machine |
US20080300642A1 (en) * | 2007-05-30 | 2008-12-04 | Japan As Represented By President Of National Cardiovascular Center | Regeneration treatment apparatus, operating method thereof, and regeneration treatment method |
CA2699642A1 (en) | 2007-09-12 | 2009-03-19 | The Regents Of The University Of California | Compositions and methods for improving the functional efficacy of stem cell-derived cardiomyocytes |
ES2530995T3 (es) | 2007-09-28 | 2015-03-09 | Anthrogenesis Corp | Supresión de tumor usando perfusato placentario humano y células asesinas naturales intermediarias que provienen de placenta humana |
US9962409B2 (en) * | 2007-10-01 | 2018-05-08 | Vestion, Inc. | Therapy using cardiac stem cells and mesenchymal stem cells |
WO2009046346A2 (en) | 2007-10-04 | 2009-04-09 | Medistem Laboratories, Inc. | Stem cell therapy for weight loss |
EP2210608B1 (en) | 2007-11-02 | 2016-08-31 | JCR Pharmaceuticals CO., LTD. | Pharmaceutical composition containing human mesenchymal stem cell |
EP2219656A2 (en) * | 2007-11-09 | 2010-08-25 | New York Medical College | Methods for the repair and/or regeneration of damaged myocardium using variants of hepatocyte growth factor |
EP2229177A1 (en) * | 2007-11-30 | 2010-09-22 | New York Medical College | Methods of isolating non-senescent cardiac stem cells and uses thereof |
US8512696B2 (en) | 2007-11-30 | 2013-08-20 | Autologous, Llc | Methods of isolating non-senescent cardiac stem cells and uses thereof |
CA2743698A1 (en) | 2007-11-30 | 2009-06-11 | New York Medical College | Compositions comprising vascular and myocyte progenitor cells and methods of their use |
AU2008334036B2 (en) | 2007-11-30 | 2014-05-29 | New York Medical College | Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells |
EP2245140A2 (en) * | 2007-11-30 | 2010-11-03 | New York Medical College | Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure |
US20100272679A1 (en) | 2007-12-14 | 2010-10-28 | Penn Marc S | Compositions and methods of promoting wound healing |
WO2009089476A1 (en) * | 2008-01-11 | 2009-07-16 | Kardia Therapeutics, Inc. | Adult human cardiac-derived progenitor cells |
CN105400735A (zh) * | 2008-01-30 | 2016-03-16 | 阿斯特利亚斯生物治疗股份公司 | 用于培养干细胞衍生的心肌细胞的合成表面 |
US20110143433A1 (en) * | 2008-03-17 | 2011-06-16 | Agency For Science, Technology And Research | Microcarriers for Stem Cell Culture |
US8828720B2 (en) * | 2008-03-17 | 2014-09-09 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
US9458431B2 (en) | 2008-03-17 | 2016-10-04 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
US8716018B2 (en) | 2008-03-17 | 2014-05-06 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
US8691569B2 (en) * | 2008-03-17 | 2014-04-08 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
US10035834B2 (en) * | 2008-06-18 | 2018-07-31 | The Texas A&M University System | Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage |
WO2010012127A1 (zh) * | 2008-07-29 | 2010-02-04 | 河北以岭医药研究院有限公司 | 一种中药组合物在制备促进骨髓间质干细胞在体存活和成心肌分化的药物中的应用 |
AU2009281809B2 (en) * | 2008-08-14 | 2015-09-17 | Mesoblast International Sarl | Purified mesenchymal stem cell compositions and methods of purifying mesenchymal stem cell compositions |
WO2010021993A1 (en) | 2008-08-19 | 2010-02-25 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease |
NZ591292A (en) | 2008-08-20 | 2012-10-26 | Anthrogenesis Corp | Improved cell composition and methods of making the same |
EP2329012B1 (en) | 2008-08-20 | 2020-05-20 | Celularity, Inc. | Treatment of stroke using isolated placental cells |
CA2734446C (en) | 2008-08-22 | 2017-06-20 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
JP5869342B2 (ja) | 2008-11-19 | 2016-02-24 | アンスロジェネシス コーポレーション | 羊膜由来接着細胞 |
US8309343B2 (en) | 2008-12-01 | 2012-11-13 | Baxter International Inc. | Apparatus and method for processing biological material |
US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
ES2665883T3 (es) | 2008-12-19 | 2018-04-30 | DePuy Synthes Products, Inc. | Tratamiento de enfermedades y trastornos pulmonares y pulmonares |
WO2010101962A1 (en) * | 2009-03-02 | 2010-09-10 | The Children's Mercy Hospital | Tissue engineered human pulmonary valves with cyclic pressure bioreactor accelerated seeding strategies and methods for assessing inflammatory potential of putative scaffolds for tissue engineered heart valves |
WO2010107392A1 (en) | 2009-03-20 | 2010-09-23 | Agency For Science, Technology And Research | Culture of pluripotent and multipotent cells on microcarriers |
EP2411504B1 (en) | 2009-03-26 | 2017-05-10 | DePuy Synthes Products, Inc. | Human umbilical cord tissue cells as therapy for alzheimer's disease |
US9301975B2 (en) | 2009-05-01 | 2016-04-05 | Biocardia, Inc. | Method of preparing autologous cells and method of use for therapy |
JP5917392B2 (ja) * | 2009-05-01 | 2016-05-11 | ビミニ テクノロジーズ リミテッド ライアビリティ カンパニー | 組織及び細胞富化グラフトを最適化するシステム、方法及び組成物 |
EP2258833B1 (en) | 2009-05-29 | 2014-03-12 | Virga Jesse Hospital | Isolation of a new cardiac stem cell population |
CA2768576C (en) * | 2009-07-21 | 2022-12-06 | Abt Holding Company | Use of stem cells to reduce leukocyte extravasation |
AU2010303469A1 (en) * | 2009-10-06 | 2012-05-03 | The Cohen Mcniece Foundation | Preparation and use of stromal cells for treatment of cardiac diseases |
AU2010324536B2 (en) | 2009-11-27 | 2016-03-03 | Stephen Anthony Livesey | A method of inducing cellular growth and materials for use therewith |
CN102725399B (zh) | 2009-12-18 | 2015-03-11 | 上海赛傲生物技术有限公司 | 制备多能干细胞的材料和方法 |
EP3284818B1 (en) | 2010-01-26 | 2022-03-09 | Celularity Inc. | Treatment of bone-related cancers using placental stem cells |
TW202011974A (zh) | 2010-04-07 | 2020-04-01 | 美商安瑟吉納西斯公司 | 利用胎盤幹細胞之血管新生 |
TW201138792A (en) | 2010-04-08 | 2011-11-16 | Anthrogenesis Corp | Treatment of sarcoidosis using placental stem cells |
US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
DK2568991T6 (en) | 2010-05-12 | 2019-03-18 | Abt Holding Co | MODULATION OF SPLENOCYTES IN CELL THERAPY |
WO2012009422A1 (en) | 2010-07-13 | 2012-01-19 | Anthrogenesis Corporation | Methods of generating natural killer cells |
US8895291B2 (en) | 2010-10-08 | 2014-11-25 | Terumo Bct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
AR093183A1 (es) | 2010-12-31 | 2015-05-27 | Anthrogenesis Corp | Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras |
KR20240042159A (ko) | 2011-02-14 | 2024-04-01 | 미메딕스 그룹 인크. | 마이크로화된 태반 조직 조성물 및 이의 제조 및 사용 방법 |
TWI602570B (zh) | 2011-06-01 | 2017-10-21 | 安瑟吉納西斯公司 | 使用胎盤幹細胞之疼痛治療 |
WO2013055476A1 (en) | 2011-09-09 | 2013-04-18 | Anthrogenesis Corporation | Treatment of amyotrophic lateral sclerosis using placental stem cells |
EP2780020A4 (en) * | 2011-11-14 | 2016-03-02 | Regenerative Sciences Llc | SUSPENDED PARTICLE DISTRIBUTION SYSTEMS AND METHODS |
AU2012358810B2 (en) | 2011-12-23 | 2018-03-15 | DePuy Synthes Products, Inc. | Detection of human umbilical cord tissue-derived cells |
US10041039B2 (en) | 2012-03-29 | 2018-08-07 | Jcr Pharmaceuticals Co., Ltd. | Method for producing pluripotent stem cells derived from dental pulp |
EP2861238A4 (en) | 2012-06-05 | 2016-03-16 | Capricor Inc | OPTIMIZED METHODS FOR GENERATING CARDIAC STEM CELLS FROM CARDIAC TISSUE AND THEIR USE IN CARDIAC THERAPY |
CA2880811C (en) | 2012-08-01 | 2021-12-07 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells |
WO2014022373A1 (en) | 2012-08-01 | 2014-02-06 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with mesenchymal stem cells |
EP2882445B1 (en) | 2012-08-13 | 2019-04-24 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
US10857266B2 (en) | 2012-08-15 | 2020-12-08 | Mimedx Group, Inc. | Reinforced placental tissue grafts and methods of making and using the same |
US9943551B2 (en) | 2012-08-15 | 2018-04-17 | Mimedx Group, Inc. | Tissue grafts composed of micronized placental tissue and methods of making and using the same |
US8904664B2 (en) | 2012-08-15 | 2014-12-09 | Mimedx Group, Inc. | Dehydration device and methods for drying biological materials |
US20140065110A1 (en) | 2012-08-31 | 2014-03-06 | The Regents Of The University Of California | Genetically modified msc and therapeutic methods |
US9663564B2 (en) | 2013-03-15 | 2017-05-30 | The Regents Of The University Of California | Vectors and methods to treat ischemia |
US9180145B2 (en) | 2012-10-12 | 2015-11-10 | Mimedx Group, Inc. | Compositions and methods for recruiting and localizing stem cells |
US8946163B2 (en) | 2012-11-19 | 2015-02-03 | Mimedx Group, Inc. | Cross-linked collagen comprising metallic anticancer agents |
JP7042017B2 (ja) | 2012-11-30 | 2022-03-29 | ヴェッション,インコーポレーテッド | 心臓幹細胞、ならびに該細胞を同定し、そして用いる方法 |
EP3878452B1 (en) * | 2013-01-09 | 2023-09-20 | United Therapeutics Corporation | Treatment of vasculopathy with prostacyclin and mesenchymal stem cells |
US10206977B1 (en) | 2013-01-18 | 2019-02-19 | Mimedx Group, Inc. | Isolated placental stem cell recruiting factors |
US9662355B2 (en) | 2013-01-18 | 2017-05-30 | Mimedx Group, Inc. | Methods for treating cardiac conditions |
WO2014123879A1 (en) | 2013-02-05 | 2014-08-14 | Anthrogenesis Corporation | Natural killer cells from placenta |
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JP2016537414A (ja) | 2013-10-29 | 2016-12-01 | ベスティオン、インク. | 心臓神経堤細胞、及びその使用方法 |
CN105992816B (zh) | 2013-11-16 | 2018-04-17 | 泰尔茂比司特公司 | 生物反应器中的细胞扩增 |
US10087436B2 (en) | 2014-02-06 | 2018-10-02 | The Regents Of The University Of California | Electrophysiologically mature cardiomyocytes and methods for making same |
WO2015140005A1 (en) | 2014-03-19 | 2015-09-24 | Ifom Fondazione Istituto Firc Di Oncologia Molecolare | Method of generation of pluripotent cells |
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US10918669B2 (en) | 2014-07-25 | 2021-02-16 | Recellerate, Inc. | Methods of treating exercise-induced pulmonary hemorrhage |
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JPWO2021153719A1 (ja) | 2020-01-30 | 2021-08-05 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996039035A1 (en) * | 1995-06-06 | 1996-12-12 | Case Western Reserve University | Myogenic differentiation of human mesenchymal stem cells |
WO1997008947A1 (fr) * | 1995-09-08 | 1997-03-13 | Takara Shuzo Co., Ltd. | Transformant |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
US5591625A (en) | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
US6099832A (en) | 1997-05-28 | 2000-08-08 | Genzyme Corporation | Transplants for myocardial scars |
-
1998
- 1998-07-14 AU AU84014/98A patent/AU8401498A/en not_active Abandoned
- 1998-07-14 AT AT98934507T patent/ATE307195T1/de active
- 1998-07-14 WO PCT/US1998/014520 patent/WO1999003973A1/en active IP Right Grant
- 1998-07-14 ES ES98934507T patent/ES2251773T5/es not_active Expired - Lifetime
- 1998-07-14 CA CA2296704A patent/CA2296704C/en not_active Expired - Lifetime
- 1998-07-14 JP JP50760299A patent/JP4562816B2/ja not_active Expired - Lifetime
- 1998-07-14 EP EP98934507A patent/EP1007631B2/en not_active Expired - Lifetime
- 1998-07-14 US US09/446,952 patent/US6387369B1/en not_active Expired - Lifetime
- 1998-07-14 DE DE69831957T patent/DE69831957T3/de not_active Expired - Lifetime
- 1998-07-14 DK DK98934507T patent/DK1007631T4/da active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996039035A1 (en) * | 1995-06-06 | 1996-12-12 | Case Western Reserve University | Myogenic differentiation of human mesenchymal stem cells |
WO1997008947A1 (fr) * | 1995-09-08 | 1997-03-13 | Takara Shuzo Co., Ltd. | Transformant |
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JP2006521121A (ja) * | 2003-03-28 | 2006-09-21 | アンジオブラスト・システムズ・インコーポレーテッド | 血管周囲の間葉系前駆細胞に誘導される血管形成 |
JP2007517036A (ja) * | 2003-12-24 | 2007-06-28 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | 房室ブロックを補うための生物学的房室間バイパスの作製 |
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JPWO2014027684A1 (ja) * | 2012-08-17 | 2016-07-28 | 株式会社Clio | 心筋梗塞の修復再生を誘導する多能性幹細胞 |
US9844570B2 (en) | 2012-08-17 | 2017-12-19 | Clio, Inc. | Pluripotent stem cell that induces repair and regeneration after myocardial infarction |
WO2014027684A1 (ja) * | 2012-08-17 | 2014-02-20 | 株式会社Clio | 心筋梗塞の修復再生を誘導する多能性幹細胞 |
US10376544B2 (en) | 2012-08-17 | 2019-08-13 | Clio, Inc. | Pluripotent stem cell that induces repair and regeneration after myocardial infarction |
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JPWO2014189071A1 (ja) * | 2013-05-22 | 2017-02-23 | 国立研究開発法人国立精神・神経医療研究センター | 移植用幹細胞及びその製造方法 |
WO2018092769A1 (ja) | 2016-11-15 | 2018-05-24 | 株式会社カネカ | 胎児付属物に由来する間葉系幹細胞を含む細胞集団とその製造方法、及び医薬組成物 |
WO2019132026A1 (ja) | 2017-12-28 | 2019-07-04 | 株式会社カネカ | 接着性幹細胞を含む細胞集団とその製造方法、及び医薬組成物 |
WO2020251020A1 (ja) | 2019-06-14 | 2020-12-17 | 株式会社カネカ | 間葉系細胞を含む細胞集団、それを含む医薬組成物、及び、その製造方法 |
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EP1007631B1 (en) | 2005-10-19 |
CA2296704A1 (en) | 1999-01-28 |
ES2251773T5 (es) | 2009-05-12 |
DE69831957D1 (de) | 2006-03-02 |
EP1007631A1 (en) | 2000-06-14 |
US6387369B1 (en) | 2002-05-14 |
EP1007631B2 (en) | 2009-02-18 |
DE69831957T3 (de) | 2009-07-23 |
WO1999003973A1 (en) | 1999-01-28 |
ATE307195T1 (de) | 2005-11-15 |
DE69831957T2 (de) | 2006-07-27 |
JP4562816B2 (ja) | 2010-10-13 |
DK1007631T4 (da) | 2009-04-27 |
CA2296704C (en) | 2010-10-19 |
EP1007631A4 (en) | 2003-05-21 |
ES2251773T3 (es) | 2006-05-01 |
AU8401498A (en) | 1999-02-10 |
DK1007631T3 (da) | 2006-03-06 |
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