JP2017148079A5 - - Google Patents
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- Publication number
- JP2017148079A5 JP2017148079A5 JP2017113273A JP2017113273A JP2017148079A5 JP 2017148079 A5 JP2017148079 A5 JP 2017148079A5 JP 2017113273 A JP2017113273 A JP 2017113273A JP 2017113273 A JP2017113273 A JP 2017113273A JP 2017148079 A5 JP2017148079 A5 JP 2017148079A5
- Authority
- JP
- Japan
- Prior art keywords
- culture medium
- cells
- pluripotent stem
- oxygen gas
- stem cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 46
- 239000001963 growth medium Substances 0.000 claims 18
- 210000000130 stem cell Anatomy 0.000 claims 15
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 13
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 12
- 229910001882 dioxygen Inorganic materials 0.000 claims 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 9
- 239000001301 oxygen Substances 0.000 claims 9
- 229910052760 oxygen Inorganic materials 0.000 claims 9
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 8
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 8
- 101000608935 Homo sapiens Leukosialin Proteins 0.000 claims 8
- 102100039564 Leukosialin Human genes 0.000 claims 8
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 8
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims 6
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 6
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 6
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 6
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 6
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 6
- 210000002966 serum Anatomy 0.000 claims 6
- 206010021143 Hypoxia Diseases 0.000 claims 3
- 102000005640 Myosin Type II Human genes 0.000 claims 3
- 108010045128 Myosin Type II Proteins 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 210000002242 embryoid body Anatomy 0.000 claims 3
- 239000003102 growth factor Substances 0.000 claims 3
- 230000001146 hypoxic effect Effects 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 239000011435 rock Substances 0.000 claims 3
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15421009P | 2009-02-20 | 2009-02-20 | |
| US61/154,210 | 2009-02-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551266A Division JP6189581B2 (ja) | 2009-02-20 | 2010-02-22 | 幹細胞の分化のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017148079A JP2017148079A (ja) | 2017-08-31 |
| JP2017148079A5 true JP2017148079A5 (enExample) | 2017-11-02 |
| JP6691509B2 JP6691509B2 (ja) | 2020-04-28 |
Family
ID=42101531
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551266A Active JP6189581B2 (ja) | 2009-02-20 | 2010-02-22 | 幹細胞の分化のための方法および組成物 |
| JP2015213836A Pending JP2016019543A (ja) | 2009-02-20 | 2015-10-30 | 幹細胞の分化のための方法および組成物 |
| JP2017113273A Active JP6691509B2 (ja) | 2009-02-20 | 2017-06-08 | 幹細胞の分化のための方法および組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551266A Active JP6189581B2 (ja) | 2009-02-20 | 2010-02-22 | 幹細胞の分化のための方法および組成物 |
| JP2015213836A Pending JP2016019543A (ja) | 2009-02-20 | 2015-10-30 | 幹細胞の分化のための方法および組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8557580B2 (enExample) |
| EP (1) | EP2398897B1 (enExample) |
| JP (3) | JP6189581B2 (enExample) |
| CA (1) | CA2753208C (enExample) |
| WO (1) | WO2010096746A1 (enExample) |
Families Citing this family (45)
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| EP2203176B1 (en) | 2007-09-28 | 2014-11-26 | Anthrogenesis Corporation | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| AU2010236632A1 (en) * | 2009-04-13 | 2011-09-15 | The Regents Of The University Of California | Methods and compositions for stem cell cultures |
| EP2539437B1 (en) | 2010-02-25 | 2017-08-02 | The Johns Hopkins University | SMOOTH MUSCLE-LIKE CELLS (SMLCs) DERIVED FROM HUMAN PLURIPOTENT STEM CELLS |
| AU2011250651B2 (en) * | 2010-05-05 | 2015-10-08 | Genea Ip Holdings Pty Limited | Media and methods for cell culture |
| US20120064040A1 (en) * | 2010-06-03 | 2012-03-15 | The Regents Of The University Of California | Serum free culture medium and supplement |
| MX342995B (es) | 2010-07-13 | 2016-10-21 | Anthrogenesis Corp | Métodos de generar células asesinas naturales. |
| EP2601289B1 (en) | 2010-08-04 | 2017-07-12 | Cellular Dynamics International, Inc. | Reprogramming immortalized b cells |
| JP5597904B2 (ja) * | 2010-09-10 | 2014-10-01 | 国立大学法人 東京大学 | 多能性幹細胞からの血液細胞分化に関する培養方法 |
| CN103201377A (zh) | 2010-11-09 | 2013-07-10 | 隆萨科隆有限公司 | 控制细胞与基质结合的方法 |
| AU2011329002C1 (en) | 2010-11-15 | 2017-05-25 | Accelerated Biosciences Corp. | Generation of neural stem cells from human trophoblast stem cells |
| US20140045265A1 (en) * | 2011-02-16 | 2014-02-13 | Salk Institute For Biological Studies | Robust and efficient differentiation of human pluripotent stem cells to multipotent vascular progenitors |
| WO2012115276A1 (en) | 2011-02-23 | 2012-08-30 | Kyoto University | Method for producing dendritic cells from pluripotent stem cells |
| WO2012141571A1 (en) * | 2011-04-11 | 2012-10-18 | M Abdullah Jaffar Ali Bin | Protein-free culture media products |
| LT2761065T (lt) * | 2011-09-29 | 2018-01-10 | Cellsnap, Llc | Kompozicijos ir būdai toksigeniškumo testavimui |
| US10428309B2 (en) | 2011-12-01 | 2019-10-01 | New York Stem Cell Foundation, Inc. | Systems and methods for producing stem cells and differentiated cells |
| WO2013082509A1 (en) * | 2011-12-01 | 2013-06-06 | The New York Stem Cell Foundation | Automated system for producing induced pluripotent stem cells or differentiated cells |
| US9428732B2 (en) | 2011-12-05 | 2016-08-30 | Primorigen Biosciences, Inc. | Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof |
| EP2820123B1 (en) * | 2012-02-29 | 2017-10-11 | The Johns Hopkins University | Method for guiding the derivation of endothelial cells from human pluripotent stem cells employing two-dimensional, feeder-free differentiation |
| EP2922866B1 (en) | 2012-11-21 | 2019-01-23 | Merz Pharma GmbH & Co. KGaA | Means and methods for determination of botulinum neurotoxin biological activity |
| EP2925860B8 (en) | 2012-11-30 | 2019-12-25 | Accelerated BioSciences Corp. | Methods of differentiating stem cells by modulating mir-124 |
| CA2896053A1 (en) | 2012-12-21 | 2014-06-26 | Ocata Therapeutics, Inc. | Methods for production of platelets from pluripotent stem cells and compositions thereof |
| EP3622960A1 (en) | 2013-02-05 | 2020-03-18 | Celularity, Inc. | Natural killer cells from placenta |
| US9994825B2 (en) | 2013-03-15 | 2018-06-12 | The Johns Hopkins University | Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix |
| ES2602078T3 (es) | 2013-03-15 | 2017-02-17 | Lonza Cologne Gmbh | Composiciones y métodos para mejorar el potencial terapéutico de las células madre |
| US9506037B2 (en) | 2013-03-15 | 2016-11-29 | The Johns Hopkins University | Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix |
| US11976110B2 (en) | 2013-06-28 | 2024-05-07 | Merz Pharma Gmbh & Co. Kgaa | Means and methods for the determination of the biological activity of neurotoxin polypeptides in cells |
| US10959997B2 (en) | 2013-12-27 | 2021-03-30 | Kyoto Prefectural Public University Corporation | Combined agent for cell therapy of corneal endothelial cell |
| US11352606B2 (en) * | 2014-02-10 | 2022-06-07 | The Johns Hopkins University | Low oxygen tension enhances endothelial fate of human pluripotent stem cells |
| US10921312B2 (en) | 2014-02-19 | 2021-02-16 | Merz Pharma Gmbh & Co. Kgaa | Gangliosides for standardizing and increasing the sensitivity of cells to botulinum neurotoxins in in vitro test systems |
| KR20160145186A (ko) | 2014-04-24 | 2016-12-19 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 입양 세포 요법 생성물을 생성하기 위한 유도 만능 줄기 세포의 응용 |
| GB2548059B (en) | 2014-11-26 | 2020-09-02 | Accelerated Biosciences Corp | Induced hepatocytes and uses thereof |
| KR102514666B1 (ko) | 2014-12-19 | 2023-03-27 | 메르츠 파마 게엠베하 운트 코. 카가아 | 세포에서 BoNT/E의 생물학적 활성의 결정을 위한 수단 및 방법 |
| US10626372B1 (en) * | 2015-01-26 | 2020-04-21 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| TWI704156B (zh) | 2015-03-04 | 2020-09-11 | 德商曼茲法瑪股份有限公司 | 用於增進肉毒桿菌神經毒素進入細胞之特定攝取的方法 |
| CN122146606A (zh) | 2015-11-04 | 2026-06-05 | 菲特治疗公司 | 用于诱导造血细胞分化的方法和组合物 |
| US12642852B1 (en) | 2015-11-04 | 2026-06-02 | Fate Therapeutics, Inc. | Genomic engineering of pluripotent cells |
| EP3690022B1 (en) | 2016-05-18 | 2026-03-18 | Keio University | Cell culture medium for culturing organoid, culture method, and organoid |
| CA3087344A1 (en) | 2018-01-05 | 2019-07-11 | Platelet Biogenesis, Inc. | Compositions and methods for producing megakaryocytes |
| JP2021529770A (ja) | 2018-06-29 | 2021-11-04 | プレートレット バイオジェネシス， インコーポレイテッド | 薬物送達のための組成物およびその使用方法 |
| EP3847243A1 (en) * | 2018-09-07 | 2021-07-14 | Wisconsin Alumni Research Foundation | Generation of hematopoietic progenitor cells from human pluripotent stem cells |
| CN110438065B (zh) * | 2019-07-25 | 2020-06-05 | 中山大学 | 一种诱导人诱导性多能干细胞分化为内皮祖细胞的方法 |
| WO2021097346A1 (en) * | 2019-11-14 | 2021-05-20 | Amgen Inc. | Hematopoietic precursor cell production |
| JPWO2022039250A1 (enExample) * | 2020-08-21 | 2022-02-24 | ||
| WO2024018018A1 (fr) | 2022-07-21 | 2024-01-25 | Etablissement Francais Du Sang | Utilisation d'un composé vitisine pour la production de cellules hématopoïétiques |
| WO2025126208A1 (en) * | 2023-12-12 | 2025-06-19 | Accellta Ltd. | Media for maintaining, differentiating, or both, pluripotent stem cells |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3065499D1 (en) | 1979-04-11 | 1983-12-15 | Mitsui Petrochemical Ind | Process for producing spherical carrier particles for olefin polymerisation catalyst, catalyst comprising such carrier particles, and use of such catalyst in olefin polymerisation |
| GB9807935D0 (en) | 1998-04-14 | 1998-06-10 | Univ Edinburgh | Lineage specific cells and progenitor cells |
| JP2001508302A (ja) | 1997-01-10 | 2001-06-26 | ライフ テクノロジーズ，インコーポレイテッド | 胚性幹細胞血清置換 |
| EP1163910B1 (en) | 1999-03-25 | 2007-09-26 | Mitsubishi Pharma Corporation | Rho kinase inhibitors for the prevention or treatment of interstitial pneumonia and pulmonary fibrosis |
| WO2000078351A1 (en) | 1999-06-18 | 2000-12-28 | Mitsubishi Pharma Corporation | Osteogenesis promoters |
| JP4563573B2 (ja) * | 2000-12-07 | 2010-10-13 | 株式会社カネカ | 抗原およびこの抗原を識別するモノクローナル抗体 |
| CA2473910C (en) | 2002-01-23 | 2011-03-15 | Bayer Pharmaceuticals Corporation | Pyrimidine derivatives as rho-kinase inhibitors |
| US6664266B2 (en) | 2002-03-14 | 2003-12-16 | Children's Medical Center Corporation | Axon regeneration with PKC inhibitiors |
| GB0206860D0 (en) | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Compounds |
| JP2005523326A (ja) | 2002-04-22 | 2005-08-04 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | プロテインキナーゼｃのペプチドインヒビター |
| US7427603B2 (en) | 2002-09-26 | 2008-09-23 | The Children's Medical Center Corporation | Method of enhancing proliferation and/or hematopoietic differentiation of stem cells |
| BRPI0514641A (pt) | 2004-09-08 | 2008-06-17 | Wisconsin Alumni Res Found | cultivação das células tronco embriÈnica humana |
| BRPI0514778B1 (pt) | 2004-09-08 | 2018-07-10 | Wisconsin Alumni Research Foundation | Meio para cultivar células tronco embrionárias |
| NZ554866A (en) | 2004-11-01 | 2010-12-24 | Wisconsin Alumni Res Found | Platelets from stem cells |
| WO2008011176A2 (en) | 2006-07-21 | 2008-01-24 | Northwestern University | Myosin light chain kinase inhibitor compounds, compositions and related methods of use |
| JP2008099662A (ja) * | 2006-09-22 | 2008-05-01 | Institute Of Physical & Chemical Research | 幹細胞の培養方法 |
| SE0950586L (sv) * | 2007-01-17 | 2009-08-13 | Wisconsin Alumni Res Found | Förbättrad odling av stamceller |
| DK3399025T3 (da) | 2007-03-23 | 2025-06-16 | Wisconsin Alumni Res Found | Omprogrammering af somatiske celler |
| JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| AU2008272949B2 (en) | 2007-06-29 | 2014-05-15 | FUJIFILM Cellular Dynamics, Inc. | Automated method and apparatus for embryonic stem cell culture |
| EP2291511B1 (en) * | 2008-05-02 | 2017-06-21 | Cellular Dynamics International, Inc. | Method for production of mast cells from stem cells |
-
2010
- 2010-02-22 EP EP10705729.1A patent/EP2398897B1/en active Active
- 2010-02-22 JP JP2011551266A patent/JP6189581B2/ja active Active
- 2010-02-22 CA CA2753208A patent/CA2753208C/en active Active
- 2010-02-22 WO PCT/US2010/024881 patent/WO2010096746A1/en not_active Ceased
- 2010-02-22 US US12/709,764 patent/US8557580B2/en active Active
-
2015
- 2015-10-30 JP JP2015213836A patent/JP2016019543A/ja active Pending
-
2017
- 2017-06-08 JP JP2017113273A patent/JP6691509B2/ja active Active
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