JP6189581B2 - 幹細胞の分化のための方法および組成物 - Google Patents
幹細胞の分化のための方法および組成物 Download PDFInfo
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- JP6189581B2 JP6189581B2 JP2011551266A JP2011551266A JP6189581B2 JP 6189581 B2 JP6189581 B2 JP 6189581B2 JP 2011551266 A JP2011551266 A JP 2011551266A JP 2011551266 A JP2011551266 A JP 2011551266A JP 6189581 B2 JP6189581 B2 JP 6189581B2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15421009P | 2009-02-20 | 2009-02-20 | |
| US61/154,210 | 2009-02-20 | ||
| PCT/US2010/024881 WO2010096746A1 (en) | 2009-02-20 | 2010-02-22 | Methods and compositions for the differentiation of stem cells |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015213836A Division JP2016019543A (ja) | 2009-02-20 | 2015-10-30 | 幹細胞の分化のための方法および組成物 |
| JP2017113273A Division JP6691509B2 (ja) | 2009-02-20 | 2017-06-08 | 幹細胞の分化のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012518415A JP2012518415A (ja) | 2012-08-16 |
| JP2012518415A5 JP2012518415A5 (enExample) | 2013-04-04 |
| JP6189581B2 true JP6189581B2 (ja) | 2017-08-30 |
Family
ID=42101531
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551266A Active JP6189581B2 (ja) | 2009-02-20 | 2010-02-22 | 幹細胞の分化のための方法および組成物 |
| JP2015213836A Pending JP2016019543A (ja) | 2009-02-20 | 2015-10-30 | 幹細胞の分化のための方法および組成物 |
| JP2017113273A Active JP6691509B2 (ja) | 2009-02-20 | 2017-06-08 | 幹細胞の分化のための方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015213836A Pending JP2016019543A (ja) | 2009-02-20 | 2015-10-30 | 幹細胞の分化のための方法および組成物 |
| JP2017113273A Active JP6691509B2 (ja) | 2009-02-20 | 2017-06-08 | 幹細胞の分化のための方法および組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8557580B2 (enExample) |
| EP (1) | EP2398897B1 (enExample) |
| JP (3) | JP6189581B2 (enExample) |
| CA (1) | CA2753208C (enExample) |
| WO (1) | WO2010096746A1 (enExample) |
Families Citing this family (45)
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| AU2008307633C1 (en) | 2007-09-28 | 2015-04-30 | Celularity Inc. | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| US8609417B2 (en) * | 2009-04-13 | 2013-12-17 | The Regents Of The University Of California | Methods and compositions for stem cell cultures |
| WO2011106681A2 (en) | 2010-02-25 | 2011-09-01 | The Johns Hopkins University | SMOOTH MUSCLE-LIKE CELLS (SMLCs) DERIVED FROM HUMAN PLURIPOTENT STEM CELLS |
| US20130071927A1 (en) * | 2010-05-05 | 2013-03-21 | Sydney Ivf Limited | Media and methods for cell culture |
| US20120064040A1 (en) * | 2010-06-03 | 2012-03-15 | The Regents Of The University Of California | Serum free culture medium and supplement |
| WO2012009422A1 (en) * | 2010-07-13 | 2012-01-19 | Anthrogenesis Corporation | Methods of generating natural killer cells |
| US8765470B2 (en) | 2010-08-04 | 2014-07-01 | Cellular Dynamics International, Inc. | Reprogramming immortalized B-cells to induced pluripotent stem cells |
| JP5597904B2 (ja) * | 2010-09-10 | 2014-10-01 | 国立大学法人 東京大学 | 多能性幹細胞からの血液細胞分化に関する培養方法 |
| US20130295669A1 (en) | 2010-11-09 | 2013-11-07 | Lonza Cologne Gmbh | Method for controlling binding of cells to a substrate |
| GB2502704B (en) | 2010-11-15 | 2019-12-04 | Accelerated Biosciences Corp | Generation of neural stem cells from human trophoblast stem cells |
| US20140045265A1 (en) * | 2011-02-16 | 2014-02-13 | Salk Institute For Biological Studies | Robust and efficient differentiation of human pluripotent stem cells to multipotent vascular progenitors |
| WO2012115276A1 (en) | 2011-02-23 | 2012-08-30 | Kyoto University | Method for producing dendritic cells from pluripotent stem cells |
| EP2697360A1 (en) * | 2011-04-11 | 2014-02-19 | Jaffar Ali Bin M. Abdullah | Protein-free culture media products |
| LT2761065T (lt) * | 2011-09-29 | 2018-01-10 | Cellsnap, Llc | Kompozicijos ir būdai toksigeniškumo testavimui |
| EP3653698B1 (en) | 2011-12-01 | 2025-04-02 | New York Stem Cell Foundation, Inc. | Automated system for producing induced pluripotent stem cells or differentiated cells |
| US10428309B2 (en) | 2011-12-01 | 2019-10-01 | New York Stem Cell Foundation, Inc. | Systems and methods for producing stem cells and differentiated cells |
| US9428732B2 (en) | 2011-12-05 | 2016-08-30 | Primorigen Biosciences, Inc. | Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof |
| AU2013225946B2 (en) * | 2012-02-29 | 2018-07-12 | The Johns Hopkins University | Method for guiding the derivation of endothelial cells from human pluripotent stem cells employing two-dimensional, feeder-free differentiation |
| MX2015006301A (es) | 2012-11-21 | 2015-09-07 | Merz Pharma Gmbh & Co Kgaa | Medios y metodos para la determinacion de la actividad biologica de la neurotoxina botulinica. |
| CN105102611B (zh) | 2012-11-30 | 2021-09-10 | 艾克塞利瑞提德生物技术公司 | 通过调节mir-124分化干细胞的方法 |
| EP3973967A1 (en) | 2012-12-21 | 2022-03-30 | Astellas Institute for Regenerative Medicine | Methods for production of platelets from pluripotent stem cells and compositions thereof |
| WO2014123879A1 (en) | 2013-02-05 | 2014-08-14 | Anthrogenesis Corporation | Natural killer cells from placenta |
| US9506037B2 (en) | 2013-03-15 | 2016-11-29 | The Johns Hopkins University | Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix |
| EP2777703B1 (en) | 2013-03-15 | 2016-09-14 | Lonza Cologne GmbH | Compositions and methods for enhancing the therapeutic potential of stem cells |
| US9994825B2 (en) | 2013-03-15 | 2018-06-12 | The Johns Hopkins University | Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix |
| PL3014267T3 (pl) | 2013-06-28 | 2019-05-31 | Merz Pharma Gmbh & Co Kgaa | Środki i sposoby określania aktywności biologicznej polipeptydów neurotoksyny w komórkach |
| WO2015097920A1 (ja) * | 2013-12-27 | 2015-07-02 | 京都府公立大学法人 | 角膜内皮細胞の細胞治療併用剤 |
| US11352606B2 (en) * | 2014-02-10 | 2022-06-07 | The Johns Hopkins University | Low oxygen tension enhances endothelial fate of human pluripotent stem cells |
| BR112016019104A2 (pt) | 2014-02-19 | 2017-10-10 | Merz Pharma Gmbh &Co Kgaa | método para padronizar a sensibilidade de neurônios, método para a geração de neurônios, método para determinar a atividade biológica, uso de gt1b |
| CA2945393C (en) | 2014-04-24 | 2021-03-23 | Board Of Regents, The University Of Texas System | Application of induced pluripotent stem cells to generate adoptive cell therapy products |
| SG11201704291QA (en) | 2014-11-26 | 2017-06-29 | Accelerated Biosciences Corp | Induced hepatocytes and uses thereof |
| CN107207586B (zh) | 2014-12-19 | 2021-07-13 | 莫茨药物股份两合公司 | 用于测定BoNT/E在细胞中的生物活性的装置和方法 |
| US10626372B1 (en) | 2015-01-26 | 2020-04-21 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| TWI704156B (zh) | 2015-03-04 | 2020-09-11 | 德商曼茲法瑪股份有限公司 | 用於增進肉毒桿菌神經毒素進入細胞之特定攝取的方法 |
| CN108473961B (zh) | 2015-11-04 | 2022-11-29 | 菲特治疗公司 | 用于诱导造血细胞分化的方法和组合物 |
| KR20250141836A (ko) | 2015-11-04 | 2025-09-29 | 페이트 세러퓨틱스, 인코포레이티드 | 만능 세포의 유전자 조작 |
| EP3690022A1 (en) | 2016-05-18 | 2020-08-05 | Keio University | Cell culture medium for culturing organoid, culture method, and organoid |
| MX2020007071A (es) | 2018-01-05 | 2020-11-11 | Platelet Biogenesis Inc | Composiciones y metodos para producir megacariocitos. |
| WO2020006539A1 (en) | 2018-06-29 | 2020-01-02 | Platelet Biogenesis, Inc. | Compositions for drug delivery and methods of use thereof |
| CA3109546A1 (en) * | 2018-09-07 | 2020-03-12 | Wisconsin Alumni Research Foundation | Generation of hematopoietic progenitor cells from human pluripotent stem cells |
| CN110438065B (zh) * | 2019-07-25 | 2020-06-05 | 中山大学 | 一种诱导人诱导性多能干细胞分化为内皮祖细胞的方法 |
| MX2022005892A (es) * | 2019-11-14 | 2022-06-14 | Amgen Inc | Produccion de celulas precursoras hematopoyeticas. |
| CN115956117A (zh) * | 2020-08-21 | 2023-04-11 | Jsr株式会社 | 人类人工多能干细胞的培养方法、人类人工多能干细胞培养物、以及脑类器官的制造方法 |
| WO2024018018A1 (fr) | 2022-07-21 | 2024-01-25 | Etablissement Francais Du Sang | Utilisation d'un composé vitisine pour la production de cellules hématopoïétiques |
| WO2025126208A1 (en) * | 2023-12-12 | 2025-06-19 | Accellta Ltd. | Media for maintaining, differentiating, or both, pluripotent stem cells |
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| DE3065499D1 (en) | 1979-04-11 | 1983-12-15 | Mitsui Petrochemical Ind | Process for producing spherical carrier particles for olefin polymerisation catalyst, catalyst comprising such carrier particles, and use of such catalyst in olefin polymerisation |
| GB9807935D0 (en) * | 1998-04-14 | 1998-06-10 | Univ Edinburgh | Lineage specific cells and progenitor cells |
| EP0986635A4 (en) | 1997-01-10 | 2001-11-07 | Life Technologies Inc | SERUM SUBSTITUTE FOR EMBRYONIC STEM CELLS |
| DE60036540T2 (de) | 1999-03-25 | 2008-07-03 | Mitsubishi Tanabe Pharma Corp. | Rho-kinase-inhibitoren für die vorbeugung oder behandlung von interstitieller pneumonie und pulmonaler fibrose |
| WO2000078351A1 (en) | 1999-06-18 | 2000-12-28 | Mitsubishi Pharma Corporation | Osteogenesis promoters |
| JP4563573B2 (ja) * | 2000-12-07 | 2010-10-13 | 株式会社カネカ | 抗原およびこの抗原を識別するモノクローナル抗体 |
| US6943172B2 (en) | 2002-01-23 | 2005-09-13 | Bayer Pharmaceuticals Corporation | Rho-kinase inhibitors |
| US6664266B2 (en) | 2002-03-14 | 2003-12-16 | Children's Medical Center Corporation | Axon regeneration with PKC inhibitiors |
| GB0206860D0 (en) | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Compounds |
| CA2785889A1 (en) | 2002-04-22 | 2003-10-30 | The Board Of Trustees Of The Leland Stanford Junior University | Peptide inhibitors of protein kinase c |
| WO2004029200A2 (en) | 2002-09-26 | 2004-04-08 | Children's Medical Center Corporation | Method of enhancing proliferation and/or hematopoietic differentiation of stem cells |
| US7442548B2 (en) | 2004-09-08 | 2008-10-28 | Wisconsin Alumni Research Foundation | Culturing human embryonic stem cells in medium containing pipecholic acid and gamma amino butyric acid |
| ES2383813T3 (es) | 2004-09-08 | 2012-06-26 | Wisconsin Alumni Research Foundation | Método de cultivo y cultivo de células madre embrionarias |
| WO2006050330A2 (en) | 2004-11-01 | 2006-05-11 | Wisconsin Alumni Research Foundation | Platelets from stem cells |
| US7732445B2 (en) | 2006-07-21 | 2010-06-08 | Northwestern University | Myosin light chain kinase inhibitor compounds, compostions and related methods of use |
| JP2008099662A (ja) * | 2006-09-22 | 2008-05-01 | Institute Of Physical & Chemical Research | 幹細胞の培養方法 |
| JP5419279B2 (ja) * | 2007-01-17 | 2014-02-19 | ウィスコンシン アラムニ リサーチ ファンデーション | 改良された幹細胞の培養 |
| EP2137296A2 (en) | 2007-03-23 | 2009-12-30 | Wisconsin Alumni Research Foundation | Somatic cell reprogramming |
| JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| KR20100059789A (ko) | 2007-06-29 | 2010-06-04 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 배아줄기세포 배양을 위한 자동화 방법 및 장치 |
| WO2009135206A1 (en) * | 2008-05-02 | 2009-11-05 | Stem Cell Products, Inc. | Method for production of mast cells from stem cells |
-
2010
- 2010-02-22 JP JP2011551266A patent/JP6189581B2/ja active Active
- 2010-02-22 CA CA2753208A patent/CA2753208C/en active Active
- 2010-02-22 EP EP10705729.1A patent/EP2398897B1/en active Active
- 2010-02-22 WO PCT/US2010/024881 patent/WO2010096746A1/en not_active Ceased
- 2010-02-22 US US12/709,764 patent/US8557580B2/en active Active
-
2015
- 2015-10-30 JP JP2015213836A patent/JP2016019543A/ja active Pending
-
2017
- 2017-06-08 JP JP2017113273A patent/JP6691509B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012518415A (ja) | 2012-08-16 |
| EP2398897B1 (en) | 2017-06-28 |
| JP2016019543A (ja) | 2016-02-04 |
| US8557580B2 (en) | 2013-10-15 |
| CA2753208C (en) | 2018-08-21 |
| JP2017148079A (ja) | 2017-08-31 |
| EP2398897A1 (en) | 2011-12-28 |
| CA2753208A1 (en) | 2010-08-26 |
| US20100216181A1 (en) | 2010-08-26 |
| JP6691509B2 (ja) | 2020-04-28 |
| WO2010096746A1 (en) | 2010-08-26 |
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