KR20150087321A - 보툴리눔 신경독소 생물학적 활성의 결정을 위한 수단 및 방법 - Google Patents
보툴리눔 신경독소 생물학적 활성의 결정을 위한 수단 및 방법 Download PDFInfo
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- KR20150087321A KR20150087321A KR1020157016033A KR20157016033A KR20150087321A KR 20150087321 A KR20150087321 A KR 20150087321A KR 1020157016033 A KR1020157016033 A KR 1020157016033A KR 20157016033 A KR20157016033 A KR 20157016033A KR 20150087321 A KR20150087321 A KR 20150087321A
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Abstract
본 발명은 신경독소 활성을 결정하기 위한 수단 및 방법에 관한 것이다. 특히, 본 발명은 신경독소 절단 부위를 포함하는 링커로 분리된, (ⅰ) 전사인자 도메인 및 (ⅱ) 세포질 유지 도메인을 포함하는 융합 폴리펩티드를 코딩하는 폴리뉴클레오티드 및 본 발명의 폴리뉴클레오티드에 의하여 코딩되는 융합 폴리펩티드에 관한 것이다. 본 발명은 또한 본 발명의 폴리뉴클레오티드를 포함하는 벡터 및 본 발명의 폴리뉴클레오티드, 벡터 또는 융합 폴리펩티드를 포함하는 숙주세포에 관한 것이다. 또한, 본 발명은 샘플 내의 신경독소 활성을 결정하기 위한 방법에 관한 것이다. 또한, 본 발명은 본 발명의 폴리뉴클레오티드, 벡터, 융합 폴리펩티드 또는 숙주세포를 샘플 내의 신경독소 활성을 결정하는 데 사용하기 위한 용도에 관한 것이다. 마지막으로, 본 발명은 신경독소 활성을 결정하기 위한 본 발명의 폴리뉴클레오티드, 벡터, 융합 폴리펩티드 또는 숙주세포를 포함하는 키트에 관한 것이다.
Description
본 발명은 보툴리눔 신경독소 생물학적 활성의 결정을 위한 수단 및 방법에 관한 것이다.
클로스트리듐 보툴리눔 (Clostridium botulinum) 및 클로스트리듐 테타니 (Clostridium tetani)는 매우 강한 독소 즉, 각각 보툴리눔 독소 (BoNTs) 및 파상풍 독소 (TeNT)를 생산한다. 이들 클로스트리듐 신경독소는 신경세포에 특이적으로 결합하며 신경전달물질 방출을 저해한다. 각각의 독소는 불활성의 미가공된 대략 150kDa 단쇄 단백질로 합성된다. 번역 후 가공 (posttranslational processing)은 이황화 결합의 형성, 및 세균성 단백질분해효소(들)에 의한 제한된 단백질분해 (손상)을 수반한다. 활성을 갖는 이중쇄 (dichain) 신경독소는 대략 50 kDa의 N-말단 경쇄 (N-terminal light chain) 및 이황화 결합에 의해 연결된 대략 100 kDa의 중쇄 (heavy chain)인 두 개의 사슬로 이루어진다. 신경독소는 구조적으로 세 개의 도메인 즉, 촉매활성을 갖는 (catalytic) 경쇄, 전좌 (translocation) 도메인 (N-말단 절반)을 포함하는 중쇄 및 수용체 결합 도메인 (C-말단 절반)으로 이루어진다. Krieglstein 1990, Eur. J. Biochem. 188, 39; Krieglstein 1991, Eur. J. Biochem. 202, 41; Krieglstein 1994, J. Protein Chem. 13, 49를 참고할 것.
클로스트리듐 보툴리눔은 A부터 G로 지정되는 일곱 개의 항원학적으로 (antigenically) 구분되는 혈청형의 상기 BoNT를 분비한다. 클로스트리듐 테타니에 의해 분비된 관련된 TeNT와 함께 모든 혈청형은 SNARE 단백질 및 특히, SNAP-25를 절단함으로써 시냅스 엑소시토시스 (synaptic exocytosis)를 차단하는 Zn2 +-의존성 엔도프로테아제 (Zn2 +-dependent endoproteases)이다. 그 중에서도 BoNTs는 보툴리즘 (botulism) 및 파상풍 (tetanus)에서 나타나는 연약 근육 마비 (flaccid muscle paralysis)를 유발한다. Fischer 2007, PNAS 104, 10447를 참고할 것.
그 독성 효과에도 불구하고, BoNTs는 수많은 질병의 치료제로 사용되어 왔다. BoNT 혈청형 A (BoNT/A)는 1989년에 미국에서 사시 (strabism), 안검경련 (blepharospasm), 및 기타 장애의 치료를 위하여 인간에게 사용하는 것이 허용되었다. 이는 예를 들어, 상표명 BOTOX (Allergan Inc)와 상표명 DYSPORT (Ipsen Ltd)하에 단백질 제제로 상업적으로 구입가능하다. 치료적 응용을 위하여, 상기 복합체는 치료될 근육으로 직접적으로 주입된다. 생리학적 pH에서, 상기 독소는 상기 단백질 복합체로부터 분비되며 원하는 약리학적 효과가 나타난다. 복합화된 단백질이 없는 개선된 BoNT/A 제제는 상표명 XEOMIN (Merz Pharmaceuticals GmbH) 하에 구입가능하다.
이론적으로, BoNTs는 수의근력을 약화시키며, 따라서, 사시, 국소성 근긴장이상증 (focal dystonia), 및 경부 근긴장이상증 (cervical dystonia), 및 양성 본태성 안검경련 (benign essential blepharospasm)과 같은 질병의 치료를 위한 효과적인 치료제이다. 이들은 또한, 반축안면경련 (hemifacial spasm), 및 국소성 경직 (focal spasticity)을 완화시키며, 위장장애 (gastrointestinal disorders), 다한증 (hyperhidrosis), 및 미용주름 교정과 같은 광범위한 기타 징후 (indications)에 효과적인 것으로 나타났다. Jost 2007, Drugs 67, 669를 참고할 것.
생물학적 활성의 결정은 품질 관리 및 양적 목적을 위하여 안전 대책만큼이나 중요하다. WO 95/33850는 비-경쟁적 분석에 기반한 신경독소의 생물학적 활성을 정량하기 위한 방법을 개시한다. 이들 방법에 있어서, 상기 신경독소에 대한 절단 부위를 포함하는 기질이 고상 (solid phase)에 결합된다. 상기 신경독소의 첨가는 기질의 절단을 야기한다. 상기 절단 산물은 그 후 예를 들어, 효소와 짝을 이루는 특이적인 항체에 의하여 검출된다. 이러한 비-경쟁적 분석의 단점은 얻어진 테스트 결과가 불균일 (inhomogeneous)하며 따라서 신뢰할 수 없다는 점이다.
보툴리눔 신경독소의 생물학적 활성의 결정을 위하여 개발된 또 다른 분석은 예를 들어, "치사 시간 (time to death)"과 같은 중독 (intoxication) 후 동물의 생존 시간의 결정 (Lamanna C, Spero L, Schantz EJ: Dependence of time to death on molecular size of botulinum toxin. Infect. Immun. 1970, 1:423-4; Kondo H, Shimizu T, Kubonoya M, Izumi N, Takahashi M, Sakaguchi G: Titration of botulinum toxins for lethal toxicity by intravenous injection into mice. Jpn. J. Med. Sci. Biol. 1984, 37:131-5; Boroff DA, Fleck U: Statistical analysis of a rapid in vivo method for the titration of the toxin of Clostridium botulinum. J. Bacteriol. 1966, 92:1580-1), 땀샘 (perspiratory glands)의 마비와 같은 살아있는 유기체의 기관 기능의 억제 (Ellies M: Experimental and clinical investigations on the inhibition of secretion of the major salivary glands with botulinum toxin A. Laryngorhinootologie 2003, 82:713-4; Monnier G, Tatu L, Parratte B, Cosson A, Michel F, Metton G: Sialorrhea, hyperhidrosis and botulinum toxin. Ann. Readapt. Med. Phys. 2003, 46:338-45), HDA와 같은 분리된 기관의 마비의 결정 (Gochel H, Wohlfarth K, Frevert J, Dengler R, Bigalke H: Botulinum A toxin therapy: neutralizing and nonneutralizing antibodies-therapeutic consequences. Exp. Neurol. 1997, 147:96-102; HUGHES R, WHALER BC. Influence of nerve-ending activity and of drugs on the rate of paralysis of rat diaphragm preparations by Cl. botulinum type A toxin. J. Physiol. 1962, 160:221-33), 일차 신경을 이용한 SNAP-25 절단 웨스턴 블롯 분석과 같은 세포 기반의 분석 (Pellett S, Tepp WH, Toth SI, Johnson EA: Comparison of the primary rat spinal cord cell (RSC) assay and the mouse bioassay for botulinum neurotoxin type A potency determination. J. Pharmacol. Toxicol. Methods 2010, 61:304-10) 및 신경독소의 생물학적 활성의 한 가지 면만을 결정하는 결합 분석 또는 SNAP-25 절단 분석과 같은 시험관 내 테스트 (Evans ER, Skipper PJ, Shone CC: An assay for botulinum toxin types A, B and F that requires both functional binding and catalytic activities within the neurotoxin. J. Appl. Microbiol. 2009, 107:1384-91; Habermann E: 125I-labeled neurotoxin from Clostridium botulinum A: preparation, binding to synaptosomes and ascent to the spinal cord. Naunyn Schmiedebergs Arch. Pharmacol. 1974, 281:47-56; Ekong TA, Feavers IM, Sesardic D: Recombinant SNAP-25 is an effective substrate for Clostridium botulinum type A toxin endopeptidase activity in vitro. Microbiology 1997, 143:3337-47)를 포함한다.
따라서 현재까지 생쥐 LD50 분석은 신경독소의 생물학적 활성을 정량하고 이들의 치료적 잠재능 및/또는 독성을 평가하기 위한 유일하게 신뢰할만한 분석이다. 상기 분석은 또한 신경독소의 제조과정에서 품질관리를 위하여 채택된다. 생쥐 LD50 생물검정에 있어서, 신경독소 폴리펩티드를 함유하는 샘플의 치사 (lethal) 또는 아치사 (sub-lethal) 농도가 적어도 120 마리의 동물 내로 주입되어야만 한다. 72시간의 관찰기에 걸쳐 사망한 동물의 숫자로 상기 샘플 내의 신경독소 폴리펩티드 농도를 결정하는 것이 가능하다. 이러한 분석의 명백한 단점은 희생될 수많은 동물의 개체수 및 상기 테스트 과정의 상기 동물들에 대한 높은 수준의 스트레스 및 고통이다.
현재까지 제안된 시험관 내 분석은 무 세포 (cell free) 시스템 내에서 SNAP-25 절단을 결정하는 것 또는 일차 신경에 대한 신경독소 노출에 기초한다. 그러나, 이들 분석은 덜 신뢰할만하며 또는, 바람직한 신경독소의 모든 기능을 고려하지는 않는다. 따라서, 현재로서는 전술된 LD50 생물검정이 유일하게 신뢰할만한 분석이고, 이는 유럽 약전에서 BoNT/A에 대한 논문에 기술되어 있다. 그러나, 공지기술로 기술된 분석방법의 단점들을 회피하는 신경독소 활성 측정을 위한 신뢰할만한 분석의 개발에 대한 필요성이 대두 된다.
본 발명은 신경독소 활성을 결정하기 위한 수단 및 방법에 관한 것이다. 특히, 이는 신경독소 절단 부위 (neurotoxin cleavage site)를 포함하는 링커로 분리된, (ⅰ) 전사인자 도메인 (transcription factor domain) 및 (ⅱ) 세포질 유지 도메인 (cytoplasmic retention domain)을 포함하는 융합 폴리펩티드 (fusion polypeptide)를 코딩하는 폴리뉴클레오티드와 본 발명의 폴리뉴클레오티드에 의하여 코딩되는 융합 폴리펩티드에 관한 것이다. 또한, 본 발명의 폴리뉴클레오티드를 포함하는 벡터 (vector) 및 본 발명의 폴리뉴클레오티드, 벡터 또는 융합 폴리펩티드를 포함하는 숙주세포가 본 발명으로 고려된다. 또한, 샘플 내 신경독소 활성을 결정하는 방법이 본 발명에 포함된다. 또한, 본 발명은 본 발명의 폴리뉴클레오티드, 벡터, 융합 폴리펩티드 또는 숙주 세포의 샘플 내 신경독소 활성을 결정하기 위한 용도에 관한 것이다. 마지막으로, 본 발명은 본 발명의 폴리뉴클레오티드, 벡터, 융합 폴리펩티드 또는 숙주 세포를 포함하는 신경독소 활성 결정용 키트에 관한 것이다.
본 발명의 일 구현 예에 따른 폴리뉴클레오티드는 신경독소 절단 부위를 포함하는 링커로 분리된, (ⅰ) 전사인자 도메인 및 (ⅱ) 세포질 유지 도메인을 포함하는 융합 폴리펩티드를 코딩하는 폴리뉴클레오티드일 수 있다.
본 발명의 다른 구현 예에 따른 폴리뉴클레오티드에 있어서, 상기 세포질 유지 도메인은 막관통 단백질 또는 막관통 단백질의 막관통 스패닝 도메인일 수 있다.
본 발명의 또 다른 구현 예에 따른 폴리뉴클레오티드에 있어서, 상기 막관통 단백질은 혈장막 신경전달물질 트랜스포터, 이온 채널, G-단백질 결합 수용체 및 막 수용체로 이루어진 군으로부터 선택될 수 있다.
본 발명의 또 다른 구현 예에 따른 폴리뉴클레오티드에 있어서, 상기 세포질 유지 도메인은 막고정 단백질 또는 막고정 단백질의 막고정 도메인일 수 있다.
본 발명의 또 다른 구현 예에 따른 폴리뉴클레오티드에 있어서, 상기 막고정 단백질은 SNAP-25, 신탁신, 시냅토브레빈, 시냅토타그민, 소포 연관 막 단백질 (VAMPs), 시냅스 소포 당단백질 (SV2), 고 친화성 콜린 트랜스포터, 뉴렉신, 전압 개폐 칼슘 채널, 아세틸콜린에스테라아제 및 NOTCH로 이루어진 군으로부터 선택될 수 있다.
본 발명의 또 다른 구현 예에 따른 폴리뉴클레오티드에 있어서, 상기 세포질 유지 도메인은 구상 단백질 및 세포골격 고정 단백질로 이루어진 군으로부터 선택될 수 있다.
본 발명의 또 다른 구현 예에 따른 폴리뉴클레오티드에 있어서, 상기 전사인자 도메인은 DNA 결합 도메인을 포함하는 전사인자 및 트랜스활성인자 또는 사일렌서 도메인을 포함할 수 있다.
본 발명의 또 다른 구현 예에 따른 폴리뉴클레오티드에 있어서, 상기 전사인자는 테트라사이클린 의존성 트랜스활성인자 (tet-억제인자-VP 16), 스테로이드 호르몬 수용체, NOTCH, NFkB, p53, NFAT, MLL, E2A, HSF1, NF-IL6, STAT, R-SMAD, GAL4, 및 SP1로 이루어진 군으로부터 선택될 수 있다.
본 발명의 일 구현 예에 따른 벡터는 상기 다양한 구현 예에 따른 본 발명의 폴리뉴클레오티드를 포함할 수 있다.
본 발명의 일 구현 예에 따른 융합 폴리펩티드는 상기 다양한 구현 예에 따른 본 발명의 폴리뉴클레오티드에 의해 코딩될 수 있다.
본 발명의 일 구현 예에 따른 숙주세포는 상기 다양한 구현 예에 따른 폴리뉴클레오티드, 상기 벡터 또는 상기 융합 폴리펩티드를 포함할 수 있다.
본 발명의 다른 구현 예에 있어서, 상기 숙주 세포는 일차 신경 세포, 신경아세포종 세포주, N1E-115 세포주, Neuro2a 세포주, SH-SY5Y 세포주, PC12 세포주, SiMa 세포주, MHH-NB-11 세포주, SK-N-BE(2) 세포주 및 유도 만능줄기세포로 이루어진 군으로부터 선택될 수 있다.
본 발명의 다른 구현 예에 있어서, 상기 숙주 세포는 상기 융합 폴리펩티드의 절단에 따라 그 발현이 전사인자 도메인에 의하여 조절되는 리포터 유전자를 포함할 수 있다.
본 발명의 일 구현 예에 따른 샘플 내의 신경독소 활성을 결정하기 위한 방법은 하기 단계: (a) 청구항 10의 융합 폴리펩티드를 포함하는 숙주 세포 및 상기 융합 폴리펩티드의 절단에 따라 그 발현이 상기 전사인자 도메인에 의하여 조절되는 리포터 유전자를 신경독소 활성을 포함하는 것으로 예상되는 샘플에 접촉시키는 단계; 및 (b) 상기 리포터 유전자 활성을 측정하는 단계;를 포함할 수 있으며, 상기 측정에 의하여 상기 샘플 내의 신경독소 활성이 결정될 수 있다.
본 발명의 다른 구현 예에 따른 샘플 내의 신경독소 활성을 결정하기 위한 방법에 있어서, 상기 숙주 세포는 상기 다양한 구현 예에 따른 숙주 세포일 수 있다.
본 발명의 일 구현 예에 따른 용도는 상기 다양한 구현 예에 따른 폴리뉴클레오티드, 상기 벡터, 상기 융합 폴리펩티드 또는 상기 다양한 구현 예에 따른 숙주 세포를 샘플 내의 신경독소 활성을 결정하기 위하여 사용하기 위한 것일 수 있다.
본 발명의 일 구현 예에 따른 키트는 상기 다양한 구현 예에 따른 폴리뉴클레오티드, 상기 벡터, 상기 융합 폴리펩티드 또는 상기 다양한 구현 예에 따른 숙주 세포 및 바람직하게는, 리포터 유전자 활성을 검출하기 위한 검출 제제를 포함할 수 있다.
도 1은 활성인자-구축체를 구축하기 위한 기본으로 사용된 Clontech사에 의해 제공된 본래의 조절 플라스미드 (a); 루시페라아제-코딩 리포터 구축체 (b); 루시페라아제-리포터 구축체를 위한 시스템 조절 플라스미드 (c)를 나타낸다 (모두 Clontech사).
도 2는 pCMV-Tet3G-벡터 (도 1a)를 골격으로 갖는 활성인자-플라스미드 mST01 (서열번호: 9) 구축의 일례를 나타낸다. 시냅토타그민 (87개의 아미노산)의 N-말단 막고정 도메인 및 SNAP25의 112개의 C-말단 아미노산을 포함하는 본 발명의 폴리뉴클레오티드가 계획된 EcoRⅠ 및 XbaⅠ절단 부위를 통하여 클로닝된다. 상기 벡터의 주요 특징이 화살표로 강조표시되어 있고 또한 그 위치를 (염기쌍 (bp)으로) 나타내는 우측 표에 나타나 있다.
도 3은 활성인자 및 리포터 구축체의 안정적인 도입에 관한 대조구로서 게놈 PCR의 결과를 나타낸다. 루시페라아제에 관해 설계된 프라이머는 ~1kb의 산물을 생산하며, Tet-인자에 관한 프라이머는 ~0.5kb의 산물을 생산한다. 강조 표시된 레인은 안정적으로 도입된 두 플라스미드 클론을 나타낸다. 전체적으로, 상기 게놈 PCR의 결과에 기초하여 24개의 생성된 클론 중 10개가 루시페라아제 및 Tet-인자에 대하여 양성이었다.
도 4는 시냅토타그민-SNAP25 융합 단백질의 막고정 구축체를 보여주는 묘사된 예시의 작용 방법의 모식도를 나타낸다.
도 2는 pCMV-Tet3G-벡터 (도 1a)를 골격으로 갖는 활성인자-플라스미드 mST01 (서열번호: 9) 구축의 일례를 나타낸다. 시냅토타그민 (87개의 아미노산)의 N-말단 막고정 도메인 및 SNAP25의 112개의 C-말단 아미노산을 포함하는 본 발명의 폴리뉴클레오티드가 계획된 EcoRⅠ 및 XbaⅠ절단 부위를 통하여 클로닝된다. 상기 벡터의 주요 특징이 화살표로 강조표시되어 있고 또한 그 위치를 (염기쌍 (bp)으로) 나타내는 우측 표에 나타나 있다.
도 3은 활성인자 및 리포터 구축체의 안정적인 도입에 관한 대조구로서 게놈 PCR의 결과를 나타낸다. 루시페라아제에 관해 설계된 프라이머는 ~1kb의 산물을 생산하며, Tet-인자에 관한 프라이머는 ~0.5kb의 산물을 생산한다. 강조 표시된 레인은 안정적으로 도입된 두 플라스미드 클론을 나타낸다. 전체적으로, 상기 게놈 PCR의 결과에 기초하여 24개의 생성된 클론 중 10개가 루시페라아제 및 Tet-인자에 대하여 양성이었다.
도 4는 시냅토타그민-SNAP25 융합 단백질의 막고정 구축체를 보여주는 묘사된 예시의 작용 방법의 모식도를 나타낸다.
따라서, 본 발명이 기초하는 기술적 과제는 전술한 요구들을 충족시키는 수단 및 방법을 제공하는 것일 수 있다. 상기 기술적 과제는 특허청구범위에서 특성화되고 이하 여기서 기술된 구현 예들에 의하여 해결된다.
본 발명은 신경독소 절단 부위를 포함하는 링커로 분리된, (ⅰ) 전사인자 도메인 및 (ⅱ) 세포질 유지 도메인을 포함하는 융합 폴리펩티드를 코딩하는 폴리뉴클레오티드에 관한 것이다.
여기서 사용된 바와 같이 용어 "폴리뉴클레오티드"는 단일 또는 이중쇄 DNA 분자뿐만 아니라, RNA분자를 의미한다. 상기 용어는 DNA, cDNA, hnRNA, mRNA뿐만 아니라, 모든 자연적으로 발생하거나 인공적으로 변형된 이러한 분자 종의 유도체를 의미한다. 상기 폴리뉴클레오티드는 선형 또는 원형 분자의 형태일 수 있다. 또한, 본 발명의 융합 폴리펩티드를 코딩하는 핵산 서열에 부가하여, 본 발명의 폴리뉴클레오티드는 5' 또는 3' UTR 서열과 같은 적절한 전사 및/또는 번역을 위하여 요구되는 추가적인 서열을 포함할 수 있다. 유전자 코드의 퇴화 (degeneracy)의 관점에서, 최적화된 코돈이 본 발명의 융합 폴리펩티드를 코딩하는 핵산 서열에 사용될 수 있다. 이에 의해, 예를 들어 본 발명의 숙주세포 내에서 최적의 발현이 이루어질 수 있다. 다른 관점에 있어서, 상기 폴리뉴클레오티드는 서열번호 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 또는 29에 나타난 핵산 서열을 포함한다. 또한, 하나의 관점에 있어서 서열번호 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30 또는 31에 나타난 아미노산 서열을 코딩하는 핵산 서열을 포함하는 폴리뉴클레오티드가 포함된다.
다른 관점에 있어서, 상기 폴리뉴클레오티드는 하나 이상의 뉴클레오티드 치환, 결실 및/또는 부가를 포함하며, 이에 따라 여전히 다른 관점에서 하나 이상의 아미노산 치환, 결실 및/또는 부가를 갖는 융합 폴리펩티드를 야기할 수 있는 전술한 폴리뉴클레오티드의 변이체이다. 또한, 다른 구현 예에 있어서 본 발명의 변이체 폴리뉴클레오티드는 서열번호 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 또는 29 중 어느 하나에 나타난 바와 같은 핵산 서열과 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 75%, 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 동일한 핵산 서열 변이체, 또는 서열번호 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30 또는 31 중 어느 하나에 나타난 바와 같은 아미노산 서열과 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 75%, 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 동일한 아미노산 서열을 코딩하는 핵산 서열 변이체를 포함한다. 여기에 사용된 바와 같이 상기 용어 "동일한"은 서열을 최고차 정합이 얻어지도록 상기 서열이 정렬되는 두 개의 핵산 서열 또는 아미노산 서열 간의 동일한 아미노산의 숫자를 결정함으로써 특징지을 수 있는 서열 상동성을 의미한다. 이는 예를 들어, BLASTP, BLASTN 또는 FASTA와 같은 컴퓨터 프로그램으로 암호화된 공지된 기법 또는 방법을 이용하여 계산될 수 있다 (Altschul 1990, J. Mol. Biol. 215, 403). 상기 퍼센트 서열 상동성 값은 일 구현 예에 있어서, 전체 뉴클레오티드 또는 아미노산 서열에 걸쳐 계산된다. 다양한 알고리즘에 기초한 일련의 프로그램이 상이한 서열을 비교하기 위하여 통상의 기술자에게 이용가능하다. 이러한 의미에서, Needleman 및 Wunsch 또는 Smith 및 Waterman의 알고리즘이 특히 신뢰할 만한 결과를 산출한다. 서열 정렬을 수행하기 위하여, 프로그램 PileUp (Higgins 1989, CABIOS 5, 151) 또는 GCG 소프트웨어 패킷 (Genetics Computer Group 1991, 575 Science Drive, Madison, Wisconsin, USA 53711)의 일부인 프로그램 Gap 및 BestFit (Needleman 1970, J. Mol. Biol. 48; 443; Smith 1981, Adv. Appl. Math. 2, 482)를 사용할 수 있다. 본 발명의 일 구현 예에 있어서, 퍼센트 (%)로 전술된 서열 상동성 값이 달리 구체화되지 않는 한, 서열 정렬을 위한 표준 세팅으로 항상 사용될 하기 세팅: 갭 가중치 (Gap Weight): 50, 길이 가중치 (Length Weight): 3, 평균 일치 (Average Match): 10.000 및 평균 불일치 (Average Mismatch): 0.000으로 전체 서열 영역에 걸쳐 프로그램 GAP을 이용하여 결정된다. 일 구현 예에 있어서, 전술된 다양한 폴리뉴클레오티드는 하나 이상의, 다른 구현 예에 있어서는 모든 본 발명의 각각의 융합 폴리펩티드의 생물학적 특질을 보유하는 융합 폴리펩티드를 코딩한다. 바람직하게는, 상기 다양한 폴리펩티드는 신경독소 절단 부위를 포함하는 링커로 분리된, (ⅰ) 전사인자 도메인 및 (ⅱ) 세포질 유지 도메인을 포함하는 융합 폴리펩티드를 코딩한다.
여기서 사용된 바와 같이, 상기 용어 "전사 인자"는 진핵세포에서 전사를 개시하거나 조절하기 위하여 요구되는 단백질을 의미한다. 전사 인자는 특이적인 DNA서열에 결합하여, DNA로부터 mRNA로의 유전 정보의 흐름 즉, 전사를 조절하는 단백질이다. 전사 인자가 결합하는 DNA 서열은 전사인자-결합 위치 또는 반응 요소 (response element)라고 불린다. 여기서 사용된 바와 같이, "인헨서 (enhancer)"는 유전자의 전사를 증가시킬 수 있는 DNA의 짧은 영역인 반면, "사일렌서 (silencer)"는 억제인자 (repressors)로 명명된 전자 조절 인자에 결합할 수 있는 DNA서열이다. 전사인자는 특이적인 유전자에 RNA 중합효소의 도입을 활성인자 (activator)로서 촉진시키거나 억제인자로서 차단함으로써 단독으로 또는 다른 단백질과 함께 복합체의 형태로 이러한 기능을 수행한다. 여기서 사용된 바와 같이, 상기 용어 "도메인"은 단백질 사슬의 나머지 부분과 독립적으로 진화하고, 기능하며 존재하는 단백질 서열 및 구조의 일부인 단백질 도메인을 나타낸다. 각각의 도메인은 밀집된 삼차원 구조를 형성하고, 종종 독립적으로 안정적이며 또한 폴딩된다. 전사인자를 포함하는 많은 단백질은 몇몇의 구조적 도메인으로 구성된다. 여기서 사용된 바와 같이, 상기 용어 "전사 인자 도메인"은 전사인자의 단백질 도메인의 전자인자를 포함한다. 전사인자는 구조적으로 모듈식이며 이에 한정되는 것은 아니나, DNA 결합 도메인, 트랜스활성인자 (transactivator) 도메인 또는 사일렌서 도메인 및 예를 들어, 리간드 결합 도메인과 같은 선택적인 신호 감지 도메인을 포함하는 몇몇의 도메인을 함유한다. DNA에 결합하는 전사인자의 부분이 DNA결합 도메인으로 불린다. DNA결합 도메인은 인헨서 또는 프로모터와 같은 특이적인 DNA서열에 부착한다. 전사인자는 정전기적 및 반데르발스힘의 조합을 이용하여 이들의 결합 위치와 상호작용한다. 이들 화학적 상호작용의 성질 때문에, 대부분의 전사인자는 서열 특이적인 방법으로 DNA에 결합한다. 그러나, 전사 인자 결합 위치의 모든 염기가 실제로 전사인자와 상호작용하는 것은 아닐 것이다. 또한, 이들 상호작용 중 일부는 다른 것들보다 더 약할 것이다. 따라서, 전사인자는 단지 하나의 서열에만 결합하는 것은 아니며, 각각 상이한 상호작용력을 갖는 밀접하게 연관된 서열의 서브세트에 결합할 수 있다. 상기 트랜스활성 도메인 즉, 트랜스활성인자 또는 사일렌서 도메인은 전사 공-제어인자 (co-regulators)와 같은 기타 단백질에 대한 결합위치를 함유한다. 트랜스활성인자 또는 사일렌서 도메인은 그들의 아미노산 조성을 따라 명명된다. 이들 아미노산은 그 활성을 위하여 필수적일 수도 있고 단지 상기 트랜스활성인자 또는 사일렌서 도메인 내에 가장 풍부한 것일 수도 있다. 전사인자는 예를 들어, DNA에 결합하여 RNA중합효소를 활성화시키거나 또는 억제시킴으로써 유전자 전사율을 조절하여 전사를 제어한다. 상기 트랜스활성 도메인은 유전자 전사율을 증가시키거나 유전자 전사율을 감소시킬 수 있다. 전자의 경우, 상기 트랜스활성 도메인은 트랜스활성인자 도메인으로 불리며, 후자의 경우, 상기 트랜스활성 도메인은 사일렌서 도메인으로 불린다. 상기 신호감지 도메인은 외부신호를 감지하고, 반응에 있어서, 이들 신호를 나머지 전사 복합체에 전달함으로써 유전자 발현을 증가 또는 감소제어하게 된다. 여기서 사용된 바와 같이, 전사인자는 예를 들어, 테트라사이클린 의존적 트랜스활성인자 (tet-repressor??P 16), 스테로이드 호르몬 수용체, NOTCH, NFκB, p53, NFAT, MLL, E2A, HSF1, NF-IL6, STAT, R-SMAD, GAL4, 또는 SP1일 수 있다. 여기서 사용된 바와 같이, 몇몇 구현 예에 있어서 상기 전사인자는 핵 위치화 서열 (nuclear localization sequence)을 포함하는 것으로 이해될 것이다. 핵 위치화 서열 또는 신호는 신호 서열 또는 신호 패치 (signal patches)일 수 있다. 핵 위치화 신호는 단백질을 세포의 핵으로 안내한다.
여기서 사용된 바와 같이, 상기 용어 "세포질 유지 도메인"은 상기 신경독소에 의하여 상기 융합 단백질을 절단하기 전에 본 발명의 폴리뉴클레오티드에 의해 코딩된 융합 폴리펩티드의 세포질 위치화를 중재하는 단백질 도메인을 나타낸다. 여기서 사용된 바와 같이, 상기 세포질 유지 도메인은 예를 들어, 막관통 단백질 (transmembrane protein) 또는 상기 막관통 단백질의 막관통 스패닝 도메인 (transmembrane spanning domain)일 수 있다. 예를 들어, 상기 막관통 단백질은 혈장막 신경전달물질 트랜스포터 (plasmalemmal neurotransmitter transporters), 이온 채널, G-단백질 결합 수용체 (G-protein coupled receptors), 또는 막 수용체 (membrane receptors)일 수 있다. 상기 세포질 유지 도메인은 또한 막고정 (membrane-anchored) 단백질 또는 막고정 단백질의 막고정 도메인 (membrane anchor domain)일 수 있다. 이러한 막고정 단백질은 예를 들어, SNAP-25, 신탁신 (Syntaxin), 시냅토브레빈 (synaptobrevin), 시냅토타그민 (synaptotagmin), 소포 연관 막 단백질 (vesicle associated membrane proteins, VAMPs), 시냅스 소포 당단백질 (synaptic vesicle glycoproteins, SV2), 고 친화성 콜린 (choline) 트랜스포터, 뉴렉신 (Neurexins), 전압 개폐 칼슘 채널, 아세틸콜린에스테라아제 또는 NOTCH일 수 있다. 여기서 사용된 바와 같이, 상기 세포질 유지 도메인은 너무 커서 핵공을 관통할 수 없는 구상 (globular) 단백질 또는 세포골격 고정 단백질 (cytoskeleton anchor protein)일 수 있다. 본 발명의 융합 폴리펩티드의 발현 후, 상기 전자 인자 도메인은 상기 세포질 유지 도메인을 통해 예를 들어, 혈장 (plasma) 또는 소포막 (vesicle membrane)에 고정되며, 따라서 상기 핵으로 이동할 수 없다. 이와 같은 방법으로, 상기 전사인자에 의한 핵 내 리포터의 발현이 회피된다. 보툴리눔 신경독소의 신경독소 경쇄에 의한 본 발명의 융합 단백질의 링커 내의 절단만이 상기 전사인자를 방출시키며 이에 의해 상기 리포터 유전자의 발현이 개시된다.
여기서 사용된 바와 같이, 상기 용어 "링커"는 신경독소 절단 부위를 포함하는 아미노산 서열의 짧은 분절인 폴리링커 (polylinker)를 나타낸다. 상응하는 DNA 서열에 의하여 코딩되는 적절한 링커 서열이 예를 들어, Schiavo G, Matteoli M, Montecucco C: Neurotoxins affecting neuroexocytosis. Physiol. Rev. 2000, 80:717-66에 기술되어 있다.
여기서 사용된 바와 같이, 상기 용어 "신경독소 절단 부위"는 신경독소 폴리펩티드의 내재성 단백질분해효소에 의하여 인지 및 절단되는 절단 부위를 의미한다. 상기 신경독소 단백질분해효소에 의하여 인지되는 절단 부위는 공지기술로 잘 알려져 있다. 예를 들어, EP 1 926 744 B1를 참고할 것. 이론적으로, 신경독소 절단 부위는 상기 신경독소 폴리펩티드 단백질분해효소에 의하여 인지 및 절단되는, 기질에서 자연적으로 발생하는 절단 부위 또는 인공적으로 설계된 절단 부위일 수 있다. 상기 신경독소 절단 부위의 특성이 본 발명의 융합 폴리펩티드를 활성화시킬 수 있는 신경독소의 종류를 좌우하는 것으로 이해될 것이다. 일 구현 예에 있어서, 여기서 언급된 신경독소 폴리펩티드는 모두 공지기술로 주지된 BoNT/A, BoNT/B, BoNT/C1, BoNT/D, BoNT/E, BoNT/G, BoNT/F 또는 TeNT를 포함한다. 예를 들어, BoNT/A에 의하여 특이적으로 인식되고 절단되는 신경독소 절단 부위가 사용되는 경우, 단지 BoNT/A 단백질분해효소만이 본 발명의 융합 폴리펩티드를 활성화시킬 수 있는 반면, BoNT/E에 의하여 특이적으로 인식되고 절단되는 신경독소 절단 부위가 사용되는 경우는 단지 BoNT/E 단백질분해효소만이 본 발명의 융합 폴리펩티드를 활성화시킬 수 있을 것이다. 본 발명의 융합 폴리펩티드의 일 구현 예에 있어서, 상기 신경독소 절단 부위는 성숙된 BoNTs에 의하여 절단된다. 이는 또 다른 구현 예에 있어서, BoNTs의 돌연변이 단백질 (muteins)에 의하여, 다른 구현 예에 있어서, 상기 BoNT 단백질분해효소 활성을 나타내는 BoNT 경쇄를 포함하거나 이로 이루어지는 돌연변이 단백질에 의하여 절단된다.
본 발명의 일 구현 예에 있어서, BoNT/A 단백질분해효소에 의하여 인식되고 절단되는 신경독소 절단 부위는 BoNT/A에 의한 절단에 민감한 단백질로부터 유래된다. 일 구현 예에 있어서, 이러한 단백질은 인간 SNAP25A 또는 SNAP25B 또는 래트, 생쥐, 소, 다니오 (Danio), 붕어 (Carassius), 개구리 (Xenopus), 토르페도 (Torpedo), 성게 (Strongylocentrotus), 꼴뚜기 (Loligo), 우렁 (Lymnaea), 또는 군소 (Aplysia)로부터 유래된 이의 상동체 (homolog), 파라로그 (paralog) 또는 오소로그 (ortholog)이다. 상기 단백질로부터 유래된 적절한 절단 부위는 EP 1 926 744 B1에 개시되어 있다.
본 발명의 일 구현 예에 있어서, BoNT/B 단백질분해효소에 의하여 인식되고 절단되는 신경독소 절단 부위는 BoNT/B에 의한 절단에 민감한 단백질로부터 유래된다. 일 구현 예에 있어서, 이러한 단백질은 인간 또는 생쥐 VAMP-1, VAMP-2 및 VAMP-3/셀루-브레빈 (VAMP-3/cellu-brevin), 소 VAMP-2, 래트 VAMP-2 또는 VAMP-3, 닭 VAMP-1, VAMP-2 또는 VAMP-3, 토르페도 VAMP-1, 성게 VAMP, 초파리 (Drosophila) sybA, synB, synC, synD, 또는 syn, 거머리 (Hirudo) VAMP, 개구리 VAMP-2 또는 VAMP-3, 다니오 (Danio) VAMP-1 또는 VAMP-2, 꼴뚜기 VAMP, 우렁 VAMP, 군소 VAMP 또는 선충 (Caenorhabditis) SNB1-유사체 또는 이들의 모든 오소로그, 파라로그 또는 상동체이다. 상기 단백질로부터 유래된 적절한 절단 부위는 EP 1 926 744 B1에 개시되어 있다.
본 발명의 일 구현 예에 있어서, BoNT/C1 단백질분해효소에 의하여 인식되고 절단되는 신경독소 절단 부위는 BoNT/C1에 의한 절단에 민감한 단백질로부터 유래된다. 일 구현 예에 있어서, 이러한 단백질은 인간 및 생쥐 신탁신 1A, 신탁신 1B1, 신탁신 2-1, 신탁신 2-2, 신탁신 2-3, 신탁신 3A 또는 신탁신 1B2, 소 또는 래트 신탁신 1A, 신탁신 1B1 또는 신탁신 1B2, 래트 신탁신 2 또는 래트 신탁신 3, 생쥐 신탁신 1A, 신탁신 1B1, 신탁신 1B2, 신탁신 2, 신탁신 3A, 신탁신 3B 또는 신탁신 3C, 닭 신탁신 1A 또는 신탁신 2; 개구리 신탁신 1A 또는 신탁신 1B, 다니오 신탁신 1A, 신탁신 1B 또는 신탁신 3, 토르페도 신탁신 1A 또는 신탁신 1B, 성게 신탁신 1A 또는 신탁신 1B, 초파리 신탁신 1A 또는 신탁신 1B, 거머리 신탁신 1A 또는 신탁신 1B, 꼴뚜기 신탁신 1A 또는 신탁신 1B, 우렁 신탁신 1A 또는 신탁신 1B 또는 이의 오소로그, 파라로그 또는 상동체이다. 상기 단백질로부터 유래된 적절한 절단 부위는 EP 1 926 744 B1에 개시되어 있다.
본 발명의 일 구현 예에 있어서, BoNT/D 단백질분해효소에 의하여 인식되고 절단되는 신경독소 절단 부위는 BoNT/D에 의한 절단에 민감한 단백질로부터 유래된다. 일 구현 예에 있어서, 이러한 단백질은 인간 또는 생쥐 VAMP-1, VAMP-2 및 VAMP-3/셀루-브레빈, 소 VAMP-2, 래트 VAMP-2 또는 VAMP-3, 닭 VAMP-1, VAMP-2 또는 VAMP-3, 토르페도 VAMP-1, 성게 VAMP, 초파리 sybA, synB, synC, synD, 또는 syn, 거머리 VAMP, 개구리 VAMP-2 또는 VAMP-3, 다니오 VAMP-1 또는 VAMP-2, 꼴뚜기 VAMP, 우렁 VAMP, 군소 VAMP 또는 선충 SNB1-유사체 또는 이의 오소로그, 파라로그 또는 상동체이다. 상기 단백질로부터 유래된 적절한 절단 부위는 EP 1 926 744 B1에 개시되어 있다.
본 발명의 일 구현 예에 있어서, BoNT/E 단백질분해효소에 의하여 인식되고 절단되는 신경독소 절단 부위는 BoNT/E에 의한 절단에 민감한 단백질로부터 유래된다. 일 구현 예에 있어서, 이러한 단백질은 인간 SNAP-25A 또는 B 또는 이의 래트, 생쥐, 소, 다니오, 붕어, 개구리, 토르페도, 성게, 꼴뚜기, 우렁, 또는 군소의 상동체, 파라로그 또는 오소로그이다. 상기 단백질로부터 유래된 적절한 절단 부위는 EP 1 926 744 B1에 개시되어 있다.
본 발명의 일 구현 예에 있어서, BoNT/F 단백질분해효소에 의하여 인식되고 절단되는 신경독소 잘단 부위는 BoNT/F에 의한 절단에 민감한 단백질로부터 유래된다. 일 구현 예에 있어서, 상기 단백질은 인간 또는 생쥐 VAMP-1, VAMP-2 및 VAMP-3/셀루-브레빈, 소 VAMP-2, 래트 VAMP-2 또는 VAMP-3, 닭 VAMP-1, VAMP-2 또는 VAMP-3, 토르페도 VAMP-1, 성게 VAMP, 초파리 sybA, synB, synC, synD, 또는 syn, 거머리 VAMP, 개구리 VAMP-2 또는 VAMP-3, 다니오 VAMP-1 또는 VAMP-2, 꼴뚜기 VAMP, 우렁 VAMP, 군소 VAMP 또는 선충 SNB1-유사체 또는 이의 오소로그, 파라로그 또는 상동체이다. 상기 단백질로부터 유래된 적절한 절단 부위는 EP 1 926 744 B1에 개시되어 있다.
본 발명의 일 구현 예에 있어서, BoNT/G 단백질분해효소에 의하여 인식되고 절단되는 신경독소 잘단 부위는 BoNT/G에 의한 절단에 민감한 단백질로부터 유래된다. 일 구현 예에 있어서, 상기 단백질은 인간 또는 생쥐 VAMP-1, VAMP-2 및 VAMP-3/셀루-브레빈, 소 VAMP-2, 래트 VAMP-2 또는 VAMP-3, 닭 VAMP-1, VAMP-2 또는 VAMP-3, 토르페도 VAMP-1, 성게 VAMP, 초파리 sybA, synB, synC, synD, 또는 syn, 거머리 VAMP, 개구리 VAMP-2 또는 VAMP-3, 다니오 VAMP-1 또는 VAMP-2, 꼴뚜기 VAMP, 우렁 VAMP, 군소 VAMP 또는 선충 SNB1-유사체 또는 이의 오소로그, 파라로그 또는 상동체이다. 상기 단백질로부터 유래된 적절한 절단 부위는 EP 1 926 744 B1에 개시되어 있다.
본 발명의 일 구현 예에 있어서, TeNT 단백질분해효소에 의하여 인식되고 절단되는 신경독소 잘단 부위는 TeNT에 의한 절단에 민감한 단백질로부터 유래된다. 일 구현 예에 있어서, 상기 단백질은 인간 또는 생쥐 VAMP-1, VAMP-2 및 VAMP-3/셀루-브레빈, 소 VAMP-2, 래트 VAMP-2 또는 VAMP-3, 닭 VAMP-1, VAMP-2 또는 VAMP-3, 토르페도 VAMP-1, 성게 VAMP, 초파리 sybA, synB, synC, synD, 또는 syn, 거머리 VAMP, 개구리 VAMP-2 또는 VAMP-3, 다니오 VAMP-1 또는 VAMP-2, 꼴뚜기 VAMP, 우렁 VAMP, 군소 VAMP 또는 선충 SNB1-유사체 또는 이의 오소로그, 파라로그 또는 상동체이다. 상기 단백질로부터 유래된 적절한 절단 부위는 EP 1 926 744 B1에 개시되어 있다.
본 발명의 폴리뉴클레오티드 또는 융합 폴리펩티드의 관점에서 상기 용어 "링커로 분리된"은 신경독소 절단 부위를 포함하는 링커가 이하 더욱 자세히 기술된 바와 같이, 전사인자 도메인과 세포질 유지 도메인 사이에 위치함을 의미한다.
신경독소와 관련하여 여기에 사용된 용어 "생물학적으로 활성인"은 여기서 특정된 생물학적 활성을 본질적으로 나타내는 즉, (a) 수용체 결합, (b) 내재화, (c) 엔도좀 막을 가로지른 시토졸 내로의 전좌 및/또는 (d) 시냅스 소포막 융합에 연관된 단백질의 내단백질분해 절단이 가능한 성숙한 신경독소를 의미한다. 바람직하게는 상기 생물학적으로 활성인 것은 신경독소의 단백질분해 활성이다.
전술된 용어의 정의 및 설명은 달리 언급되는 경우를 제외하고는 하기 서술된 내용에 기술된 모든 관점에서 준용되는 것으로 이해될 것이다.
본 발명의 수단 및 방법은 세포 내, 바람직하게는 여기서 더욱 정의된 바와 같이 신경세포 내에서 보툴리눔 신경독소에 의한 융합 폴리펩티드로부터 전자인자 도메인의 단백질분해 방출에 기초한다. 상기 전자인자 도메인은 본 발명의 폴리뉴클레오티드 또는 융합 폴리펩티드의 일 관점에서 신경독소 절단 부위를 포함하는 링커를 통하여 세포질 유지 도메인에 융합될 수 있다. 상기 융합 폴리펩티드의 발현 후에, 상기 전사인자 도메인은 일차적으로 상기 세포질에 고정된다. 이는 막관통 단백질 또는 막관통 단백질의 막관통 스패닝 (spanning) 도메인, 막고정 단백질 또는 막고정 단백질의 막고정 도메인, 또는 구형 단백질 또는 세포골격 고정 단백질 (cytoskeleton anchor protein)과 같은 본 발명의 폴리뉴클레오티드 또는 융합 폴리펩티드 내의 적절한 세포질 유지 신호를 이용함으로써 달성될 수 있다. 상기 세포질 유지 신호는 상기 전자인자 도메인이 상기 세포 핵으로 전좌되는 것을 방지한다. 보툴리눔 신경독소의 단백질분해 활성만이 상기 신경독소 절단 부위를 포함하는 링커 내의 상기 융합 단백질의 절단에 의하여 상기 전사인자 도메인을 상기 융합 폴리펩티드로부터 방출시킨다. 이에 의해 상기 전사인자 도메인이 루시페라아제, 알칼리 포스파타아제, 또는 서양고추냉이 과산화효소 (horseradish peroxidase)와 같은 리포터 단백질의 발현이 개시될 수 있는 핵으로 전좌 된다. 발현된 리포터 단백질의 존재 및/또는 양은 공지기술로 주지된 분석방법인 예를 들어, 효소 테스트에 의하여 분석될 수 있다 (Miraglia LJ, King FJ, Damoiseaux R: Seeing the light: luminescent reporter gene assays. Comb. Chem. High Throughput Screen 2011, 14:648-57; Fan F, Wood KV: Bioluminescent assays for high-throughput screening. Assay Drug Dev. Technol. 2007, 5:127-36). 발현된 리포터의 양은 세포질 내의 신경독소 경쇄의 단백질분해 활성에 직접적으로 비례하며, 이에 따라 또한 보툴리눔 신경독소의 생물학적 활성에 비례한다. 정의된 생물학적 활성을 갖는 참조 보툴리눔 신경독소를 이용한 이러한 분석의 결과를 비교함으로써, 시료 내의 미지의 보툴리눔 신경독소의 생물학적 활성이 결정될 수 있다.
유리하게도, 본 발명의 폴리뉴클레오티드 및 융합 폴리펩티드는 세포 배양 시스템 내에서 주어진 신경독소 폴리펩티드의 단백질분해효소 활성을 결정할 수 있게 한다. 따라서, 본 발명에 의하여 고비용이며 윤리적으로 불필요한 동물실험을 피하거나 줄일 수 있다. 또한, 본 발명의 폴리뉴클레오티드 및 융합 폴리펩티드는 자동화된 대용량 탐색 분석에 적용될 수 있다. 본 발명의 폴리뉴클레오티드 및 융합 폴리펩티드는 또한 예를 들어, 신경아세포종 (neuroblastoma) 세포주와 같은 세포주에서의 분석을 확립하는 것을 가능하게 한다. 따라서, 다른 세포 기반의 신경독소 분석에서 요구되는 것과 같은 일차 신경의 사용을 피할 수 있게 된다. 일차 신경의 준비가 번거롭고 비효율적이므로 이는 본 발명의 방법 및 수단의 또 다른 장점이다. 또한, 여기서 기술된 수단 및 방법을 이용함으로써, 보툴리눔 신경독소의 생물학적 활성을 결정하기 위한 세포 기반의 분석의 민감도 및 유동률 (flow rate)이 상당히 증가될 수 있었다. 따라서, 본 발명은 보툴리눔 신경독소의 생물학적 활성을 테스트하기 위한 개선된 분석방법을 제공한다.
본 발명의 폴리뉴클레오티드의 일 관점에서, 상기 세포질 유지 도메인은 막관통 단백질 또는 막관통 단백질의 막관통 스패닝 도메인이다. 적절한 세포질 유지 도메인을 사용함으로써, 본 발명의 융합 단백질은 상기 신경독소 경쇄가 생물학적으로 활성인 세포의 구획 내 즉, 세포질로 운반되거나 또는 여기에 보유된다. 환언하면, 신경독소 절단에 의한 활성화 전에 상기 융합 폴리펩티드의 발현 후에, 상기 전사인자 도메인이 상기 세포질에 고정된다. 이와 같은 본 발명의 융합 폴리펩티드를 코딩하는 폴리뉴클레오티드의 관점에서, 이러한 세포질 유지 도메인은 막관통 단백질 또는 막관통 단백질의 막관통 스패닝 도메인이다.
본 발명의 폴리뉴클레오티드의 다른 구현 예에 있어서, 상기 막관통 단백질은 혈장막 신경전달물질 트랜스포터, 이온 채널, G-단백질 결합 수용체 및 막 수용체로 이루어진 군으로부터 선택된다.
본 발명의 폴리뉴클레오티드의 다른 구현 예에 있어서, 상기 세포질 유지 도메인은 막고정 단백질 또는 막고정 단백질의 막고정 도메인이다. 본 발명의 폴리뉴클레오티드의 일 구현 예에 있어서, 상기 막고정 단백질은 SNAP-25, 신탁신, 시냅토브레빈, 시냅토타그민, 소포 연관 막 단백질 (VAMPs), 시냅스 소포 당단백질 (SV2), 고 친화성 콜린 트랜스포터, 뉴렉신, 전압 개폐 칼슘 채널, 아세틸콜린에스테라아제 및 NOTCH로 이루어진 군으로부터 선택된다. 이하, 각각의 단백질의 상응하는 접근 번호가 나타나 있다: 인간 SNAP-25 P60880, 인간 신탁신-1A Q16623, 신탁신-1B P61266, 신탁신-2 P32856, 신탁신-3 Q13277, 신탁신-4 Q12846, 신탁신-5 Q13190, 신탁신-6 O43752, 신탁신-7 O15400, 신탁신-8 Q9UNK0, 신탁신-10 O60499, 신탁신-11 O75558, 신탁신-12 Q86Y82, 신탁신-16 O14662, 신탁신-17 P56962, 신탁신-18 Q9P2W9, 신탁신-19 Q8N4C7; 인간 시냅토브레빈-1 P23763, 시냅토브레빈-2 P63027, 시냅토브레빈-3 Q15836; 인간 시냅토타그민: 시냅토타그민-1 P21579, 시냅토타그민-2 Q8N9I0, 시냅토타그민-3 Q9BQG1, 시냅토타그민-4 Q9H2B2, 시냅토타그민-5 O00445, 시냅토타그민-6 Q5T7P8, 시냅토타그민-8 Q8NBV8, 시냅토타그민-9 Q86SS6, 시냅토타그민-10 Q6XYQ8, 시냅토타그민-11 Q9BT88, 시냅토타그민-12 Q8IV01, 시냅토타그민-13 Q7L8C5, 시냅토타그민-14 Q8NB59, 시냅토타그민-15 Q9BQS2, 시냅토타그민-16 Q17RD7, 시냅토타그민-17 Q9BSW7, 인간 소포 연관 막단백질 (VAMPs): 소포 연관 막단백질 1 P23763, 소포 연관 막단백질 2 P63027, 소포 연관 막단백질 3 Q15836, 소포 연관 막단백질 4 O75379, 소포 연관 막단백질 5 O95183, 소포 연관 막단백질 7 P51809, 소포 연관 막단백질 8 Q9BV40; 시냅스 소포 당단백질 (SV2): 시냅스 소포 당단백질 2A Q7L0J3, 시냅스 소포 당단백질 2B Q7L1I2, 시냅스 소포 당단백질 2C Q496J9; 인간 고친화성 콜린 트랜스포터 Q9GZV3; 인간 뉴렉신: 뉴렉신-1-알파 Q9ULB1, 뉴렉신-1-베타 P58400, 뉴렉신-2-알파 Q9P2S2, 뉴렉신-2-베타 P58401, 뉴렉신-3-알파 Q9Y4C0, 뉴렉신-3-베타 Q9HDB5; 인간 전압 개폐 칼슘 채널: 전압-의존성 칼슘 채널 서브유닛 알파-2/델타-1 P54289, 전압-의존성 칼슘 채널 서브유닛 Q9NY47, 전압-의존성 칼슘 채널 서브유닛 Q8IZS8, 전압-의존성 칼슘 채널 서브유닛 Q7Z3S7, 전압-의존성 P/Q-타입 칼슘 채널 서브유닛 O00555, 전압-의존성 N-타입 칼슘 채널 서브유닛 Q00975, 전압-의존성 L-타입 칼슘 채널 서브유닛 Q13936, 전압-의존성 L-타입 칼슘 채널 서브유닛 Q01668, 전압-의존성 R-타입 칼슘 채널 서브유닛 Q15878, 전압-의존성 L-타입 칼슘 채널 서브유닛 O60840, 전압-의존성 T-타입 칼슘 채널 서브유닛 O43497, 전압-의존성 T-타입 칼슘 채널 서브유닛 O95180, 전압-의존성 T-타입 칼슘 채널 서브유닛 Q9P0X4, 전압-의존성 L-타입 칼슘 채널 서브유닛 Q13698, 전압-의존성 L-타입 칼슘 채널 서브유닛 Q02641, 전압-의존성 L-타입 칼슘 채널 서브유닛 Q08289, 전압-의존성 L-타입 칼슘 채널 서브유닛 P54284, 전압-의존성 L-타입 칼슘 채널 서브유닛 O00305, 전압-의존성 칼슘 채널 감마-1 서브유닛 Q06432, 전압-의존성 칼슘 채널 감마-2 서브유닛 Q9Y698, 전압-의존성 칼슘 채널 감마-3 서브유닛 O60359, 전압-의존성 칼슘 채널 감마-4 서브유닛 Q9UBN1, 전압-의존성 칼슘 채널 감마-5 서브유닛 Q9UF02, 전압-의존성 칼슘 채널 감마-6 서브유닛 Q9BXT2, 전압-의존성 칼슘 채널 감마-7 서브유닛 P62955, 전압-의존성 칼슘 채널 감마-8 서브유닛 Q8WXS5, 전압-의존성 칼슘 채널 감마-유사체 서브유닛 Q8WXS4, 전압 개폐 칼슘 채널 알파 1F 서브유닛 F5CIQ9, 나트륨 누수 채널 비선택적 단백질 Q8IZF0, 전압 개폐 칼슘 채널 베타 2 서브유닛 Q5QJ99, 전압 개폐 칼슘 채널 베타 2 서브유닛 Q5QJA0, 전압 개폐 L-타입 칼슘 채널 Cav1.2 Q5V9X8, 전압 개폐 L-타입 칼슘 채널 Cav1.2 Q5V9X9, 전압 개폐 칼슘 채널 베타 2 서브유닛 Q6TME0, 전압 개폐 칼슘 채널 베타 2 서브유닛 Q6TME1, 전압 개폐 칼슘 채널 베타 2 서브유닛 Q6TME2, 전압 개폐 칼슘 채널 베타 2 서브유닛 Q6TME3, 전압 개폐 칼슘 채널 베타 1 서브유닛 Q6TME4, 전압 개폐 칼슘 채널 알파 1 서브유닛 Q71UT1, 전압 개폐 칼슘 채널 알파 1E 서브유닛 Q9UN68; 인간 아세틸콜린에스테라아제 P22303; 및 인간 NOTCH: 신경성 위치 노치 상동체 단백질 (Neurogenic locus notch homolog protein) 1 P46531, 신경성 위치 노치 상동체 단백질 2 Q04721, 신경성 위치 노치 상동체 단백질 3 Q9UM47, 신경성 위치 노치 상동체 단백질 4 Q99466.
본 발명의 폴리뉴클레오티드의 이러한 구현 예에 있어서, 전-시냅스 막에 또는 그 안에 위치되는 단백질을 선택하는 것이 유리하다. 기본적으로 막고정 또는 막단백질과의 상호작용에 사용될 수 있는 모든 단백질이 예를 들어, 원형질막 또는 소포막과 같은 상기 막에 위치될 수 있는 것으로 이해될 것이다. 이러한 단백질은 바람직하게는 상기 신경독소 경쇄가 그 생물학적 활성을 발휘하는 구획 즉, 예를 들어 신경 세포와 같은 세포의 세포질 내에 존재한다. 상기 생물학적 활성은 상기 신경독소 수용체에의 결합, 상기 신경독소 경쇄의 표적 세포의 시토졸 내로의 전좌 및 상기 신경독소의 경쇄에 의해 매개되는 신경독소의 단백질분해 활성으로 구성된다.
본 발명의 폴리뉴클레오티드의 또 다른 구현 예에 있어서, 상기 세포질 유지 도메인은 구셩 단백질 또는 세포골격 고정 단백질로부터 선택된다. 이와 같은 구현 예에 있어서, 상기 전사인자는 상기 융합 폴리펩티드가 상기 핵의 핵공을 통과하는 것을 방지하기에 충분히 큰 거대한 구형 단백질 또는 세포골격 고정 단백질에 융합된다. 이와 같은 방법으로, 상기 핵의 핵공을 통한 (전사 활성 도메인을 포함하는) 융합 단백질의 이동이 회피될 수 있다. 구형 단백질 또는 세포골격 고정 단백질은 단독으로 또는 다른 단백질 또는 엑스포틴 (exportin) 결합 도메인 또는 IκB 결합 도메인과 같은 단백질 도메인에 융합되어 사용될 수 있는 것으로 여겨진다. 본 발명은 "x"가 모든 자연적으로 발생하는 아미노산을 의미하는 류신-풍부 핵 배출 신호 (leucine-rich nuclear export signal, NES): (LxxxLxxLxL; 서열번호: 32)에 대하여 예시화 되었다.
본 발명의 다른 구현 예에 있어서, 상기 전사인자 도메인은 DNA 결합 도메인 및 트랜스활성인자 또는 사일렌서 도메인을 포함하는 전사인자를 포함한다. 다른 구현 예에 있어서, 상기 전사인자는 상기 DNA 결합 도메인 및 트랜스활성인자 또는 사일렌서 도메인과 더불어, 핵 위치화 서열을 포함한다. 몇몇 구현 예에 있어서, 예를 들어, 상기 사일렌서 또는 억제인자 (예를 들어, REST)는 상기 절단 부위가 사일렌서/억제인자와 트랜스활성인자 도메인에 끼어들 수 있도록 상기 트랜스활성인자 도메인에 반대로 위치될 수 있다. 이에 의해 상기 리포터의 기본적인 발현에 있어서 추가적인 감소가 야기된다. 상기 핵 위치화 신호는 단백질은 상기 세포의 핵으로 안내한다. 여기에 사용된 바와 같이 상기 전사인자는 상기 리포터 유전자의 발현을 조절할 수 있는 것으로 즉, 상기 전사인자는 리포터 유전자의 발현을 증가 또는 감소시킬 수 있는 것으로 이해될 것이다.
본 발명의 폴리뉴클레오티드의 또 다른 구현 예에 있어서, 상기 전사인자는 테트라사이클린 의존성 트랜스활성인자 (tet-억제인자-VP 16), 스테로이드 호르몬 수용체, NOTCH, NFκB, p53, NFAT, MLL, E2A, HSF1, NF-IL6, STAT, R-SMAD, GAL4, 및 SP1으로 이루어진 군으로부터 선택된다. 상기 테트라사이클린 의존성 트랜스활성인자에 대한 아미노산 서열이 예를 들어 서열번호 33 또는 34로 나타나 있다:
"SRLDKSKVINSALELLNGVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALPIEMLDRHHTHSCPLEGESWQDFLRNNAKSYRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEEQEHQVAKEERETPTTDSMPPLLKQAIELFDRQGAEPAFLFGLELIICGLEKQLKCESGGPTDALDDFDLDMLPADALDDFDLDMLPADALDDFDLDMLPG" (서열번호: 33)
"SRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGSAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG" (서열번호: 34).
상기 tet-억제인자의 아미노산 서열이 접근번호 P04483로 나타나 있다. VP16의 아미노산 서열이 접근번호 P06492로 나타나 있다. 스테로이드 호르몬 또는 기타 핵 수용체에 대한 해당 접근번호는 다음과 같다: 안드로겐 수용체 P10275, 에스트로겐 수용체 P03372, 글루코코르티코이드 수용체 P04150, 미네랄로코르티코이드 수용체 P08235, 프로게스테론 수용체 P06401, 프로락틴 수용체 P16471, 레티노산 수용체 알파 P10276, 레티노산 수용체 감마 P13631, 레티노산 수용체 RXR-알파 P19793, 스테로이드 호르몬 수용체 ERR1 P11474, 스테로이드 호르몬 수용체 ERR2 O95718, 갑상선 호르몬 수용체 알파 P10827, 갑상선 호르몬 수용체 베타 P10828. NOTCH 단백질에 대한 해당 접근번호는 다음과 같다: 신경성 위치 노치 상동체 단백질 1 P46531, 신경성 위치 노치 상동체 단백질 2 Q04721, 신경성 위치 노치 상동체 단백질 3 Q9UM47, 신경성 위치 노치 상동체 단백질 4 Q99466. NFκB에 대한 해당 접근번호는 Q04206이며; p53에 대하여는 P04637; NFAT: 활성화된 T-세포의 핵인자 (Nuclear factor of activated T-cells) 1 O95644, 활성화된 T-세포의 핵인자 2 Q13469, 활성화된 T-세포의 핵인자 3 Q12968, 활성화된 T-세포의 핵인자 4 Q14934, 활성화된 T-세포의 핵인자 5 O94916; E2A (전사인자 E2-알파)에 대하여 P15923; HSF1에 대하여 Q00613; NF-IL6에 대하여 P17676; STAT: STAT1_HUMAN에 대하여 P42224, STAT2_HUMAN P52630, STAT3_HUMAN P40763, STAT4_HUMAN Q14765, STA5A_HUMAN P42229, STA5B_HUMAN P51692, STAT6_HUMAN P42226; R-SMAD: 열다섯 개의 성충 디스크를 갖는 상동체에 대한 모체 (Mothers against decapentaplegic homolog) 1에 대하여 Q15797, 열다섯 개의 성충 디스크를 갖는 상동체에 대한 모체 2 Q15796, 열다섯 개의 성충 디스크를 갖는 상동체에 대한 모체 3 P84022, 열다섯 개의 성충 디스크를 갖는 상동체에 대한 모체 4 Q13485, 열다섯 개의 성충 디스크를 갖는 상동체에 대한 모체 5 Q99717, 열다섯 개의 성충 디스크를 갖는 상동체에 대한 모체 6 O43541, 열다섯 개의 성충 디스크를 갖는 상동체에 대한 모체 7 O15105, 열다섯 개의 성충 디스크를 갖는 상동체에 대한 모체 9 O15198; GAL4 및 SP1에 대하여 P08047.
본 발명은 또한 본 발명의 폴리뉴클레오티드를 포함하는 벡터에 관한 것이다. 일 구현 예에 있어서, 상기 벡터는 발현 벡터이다.
상기 용어 "벡터"는 바람직하게는 파지 (phage), 플라스미드, 바이러스성 또는 레트로바이러스성 벡터뿐만 아니라 세균 또는 효모 인공 염색체와 같은 인공 염색체를 포함한다. 또한, 상기 용어는 표적 구축체의 유전체 DNA내로의 무작위 또는 위치-지정 삽입에 대한 표적 구축체에 관한 것이기도 하다. 이러한 표적 구축체는 바람직하게는, 하기 자세히 기술된 바와 같이 상동성 (homologous) 또는 비상동성 (heterologous) 재조합을 위하여 충분한 길이의 DNA를 포함한다. 본 발명의 폴리뉴클레오티드를 포함하는 벡터는 일 구현 예에 있어서, 숙주 내에서의 증식 및/또는 선택을 위한 선택 마커를 더욱 포함한다. 상기 벡터는 관련 기술분야에 주지된 다양한 기법에 의하여 숙주 내로 도입될 수 있다. 예를 들어, 플라스미드 벡터가 칼슘 포스페이트 침전물 또는 염화 류비듐 침전물과 같은 침전물 또는 전하를 띈 지질 또는 풀러린 (fullerens)과 같은 탄소-기반의 클러스터를 갖는 복합체 내에 도입될 수 있다. 선택적으로, 플라스미드 벡터는 열충격 또는 전기천공 기법에 의하여 도입될 수 있다. 상기 벡터가 바이러스인 경우, 이는 숙주 세포로 도입되기 전에 시험관 내에서 적절한 패키징 세포주를 이용하여 패키징될 수 있다. 레트로바이러스성 벡터는 복제가능하거나 또는 복제 결함일 수 있다. 후자의 경우, 바이러스성 증식은 일반적으로 단지 상보적인 숙주/세포 내에서만 일어날 것이다. 또한, 본 발명의 일 구현 예에 있어서, 상기 폴리뉴클레오티드는 상기 벡터 내에서 원핵 또는 진핵 숙주 세포 내에서 발현을 가능하게 하는 발현 조절 서열 또는 이의 분리된 분획에 작동적으로 연결된다. 상기 폴리뉴클레오티드의 발현은 상기 폴리뉴클레오티드의 번역가능한 mRNA로의 전사를 포함한다. 숙주 세포 내에서 발현을 담당하는 조절 인자는 공지기술로 주지되어 있다. 일 구현 예에 있어서, 이들은 전사의 개시를 담당하는 조절 서열 및/또는 전사의 종결 및 상기 전사체의 안정화를 담당하는 폴리-A-신호를 포함한다. 추가적인 조절 인자로는 전사 인헨서 및 번역 인헨서가 포함될 수 있다. 원핵 숙주 세포 내에서의 발현을 허용하는 가능한 조절 인자로는 예를 들어, 대장균 (E. coli) 내의 lac-, trp- 또는 tac- 프로모터가 포함되며, 진핵 숙주 세포 내에서의 발현을 허용하는 가능한 조절 인자는 효모 내의 AOX1- 또는 GAL1- 프로모터 또는 포유동물 및 다른 동물 세포 내의 CMV-, SV40-, RSV-프로모터 (라우스 육종 바이러스), CMV-인헨서, SV40-인헨서 또는 글로빈 인트론이다. 본 발명에 포함되는 다른 발현 시스템은 폴리헤드린 (polyhedrin) 프로모터 기반 시스템과 같은 곤충 세포 내의 발현을 허용할 것이다.
또한, 유도 발현 조절 서열이 본 발명에 포함되는 발현 벡터에 사용될 수 있다. 유도 발현 시스템 및 적절한 발현 조절 서열은 공지기술로 주지되어 있다. 예를 들어, 전사 트랜스활성을 위한 테트라사이클린-반응성 조절 시스템이 Zhu Z, Zheng T, Lee CG, Homer RJ, Elias JA: Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling. Semin. Cell Dev. Biol. 2002, 13:121-8; 또는 Shockett P, Schatz D: Inducible gene expression using an autoregulatory, tetracycline-controlled system. Curr. Protoc. Mol. Biol. 2002, Chapter 16: Unit 16.14에 기술되어 있다. 이러한 유도 벡터는 tet 또는 lac 작동인자 (operator) 서열 또는 열충격 또는 공지기술로 개시된 기타 환경적 요인에 의해 유도될 수 있는 서열을 포함할 수 있다. 예를 들어, 두 개의 일반적으로 사용되는 유도 발현 시스템은 Tet-Off 및 Tet-On이다. Bujard and Gossen, Proc. Natl. Acad. Sci. U.S.A. 89 (12): 5547-51를 참고할 것. 이들은 억제인자보다는 전사 활성인자 단백질 (트랜스활성인자)를 만들기 위하여 Tet 억제인자 및VP16 활성 도메인의 융합으로 구성된다. 유전자 발현은 Tet-Off 또는 Tet-On 단백질의 유도 프로모터 내에 위치하는 테트라사이클린 반응 인자 (TREs)에 결합함으로써 활성화된다. 상기 차이는 이들 각각의 더욱 안정적인 테트라사이클린 유사체인 독시사이클린 (doxycycline, Dox)에 대한 반응과 관련된다: Tet-Off는 Dox의 부존재하에서 발현을 활성화시키는 반면, Tet-On은 Dox의 존재하에서 활성화시킨다. 적절한 벡터를 상업적으로 구입가능하다. 예를 들어, Clontech사에 의해 출시된 Tet-On 3G 벡터가 엄격하게 조절되며 반응성이 높고 상기 배양 배지에 독시사이클린을 첨가함으로써 작동되는 테트라사이클린 (Tet)-유도 포유동물 발현 시스템을 구축하기 위하여 사용될 수 있다. pCMV-Tet3G 벡터는 유도인자인 독시사이클린의 존재하에서는 높은 활성을 나타내며 부존재하에서는 특히 낮은 활성을 나타내는 테트라사이클린-조절 트랜스활성인자인 Tet-On 3G를 발현한다. Tet-On 3G은 돌연변이 Tet 억제인자 (TetR)의 아미노산 1-207를 단순 헤르페스 바이러스 VP16 단백질로부터 유래된 세 개의 최소 "F" 타입 전사 활성 도메인을 형성하는 39개의 아미노산에 융합시킴으로써 얻어진다. Tet-On 3G의 구성적 발현이 인간 사이토메갈로바이러스 (cytomegalovirus) 급초기 프로모터 (immediate early promoter) (PCMV IE)에 의하여 유도된다. 또한, EF1알파 버젼은 그 내부에서 CMV 프로모터가 사일렌싱되는 세포주를 위하여 사용가능하다. 더욱 자세한 정보를 위하여 Clontech사의 카탈로그 번호 631163 및 여기에 인용된 참고문헌을 참고할 것. 전사 개시에 관여하는 인자 외에도, 이러한 조절 인자는 또한 SV40-폴리-A 부위 또는 상기 폴리뉴클레오티드의 하류인 tk-폴리-A 부위와 같은 전사 종결 신호를 포함한다. 이러한 관점에서, 적절한 발현 벡터가 Okayama-Berg cDNA 발현 벡터 pcDV1 (Pharmacia), pBluescript (Stratagene), pCDM8, pRc/CMV, pcDNA1, pcDNA3, pcDNA3.1 (Invitrogen) 또는 pSPORT1 (Invitrogen) 또는 배큘로바이러스-유래 벡터와 같이 공지기술로 알려져 있다. 바람직하게는, 상기 벡터는 발현 벡터 및 유전자 운반 또는 표적 벡터이다. 레트로바이러스, 우두바이러스 (vaccinia virus), 아데노-연관 바이러스, 헤르페스 바이러스, 또는 소유두종바이러스 (bovine papilloma virus)와 같은 바이러스로부터 유래된 발현 벡터가 본 발명의 폴리뉴클레오티드 또는 벡터를 표적 세포 집단 내로 운반하기 위하여 사용될 수 있다. 통상의 기술자에게 주지된 방법이 재조합 바이러스성 벡터를 구축하기 위하여 사용될 수 있다. 예를 들어, Sambrook, Molecular Cloning A Laboratory Manual, Cold Spring Harbor Laboratory (1989) N.Y. 및 Ausubel, Current Protocols in Molecular Biology, Green Publishing Associates and Wiley Interscience, N.Y. (1994)에 기술된 기법을 참고할 것.
또한, 본 발명은 본 발명의 폴리뉴클레오티드에 의하여 코딩되는 융합 폴리펩티드에 관한 것이다. 여기서 사용된 바와 같이, 상기 용어 "융합 폴리펩티드"는 (ⅰ) 전사인자 도메인 및 (ⅱ) 세포질 유지 도메인을 포함하는 융합 폴리펩티드를 지칭한다. 상기 전사인자 도메인 및 상기 세포질 유지 도메인은 신경독소 절단 부위를 포함하는 링커로 분리되어 있다. 상기 링커에서의 단백질분해 절단은 상기 링커가 (적어도) 한번 절단되는 방식으로 상기 신경독소 절단 부위에서 일어난다. 상기 링커는 하나 이상의 신경독소 절단 부위(들)을 포함할 수 있다. 융합 폴리펩티드 또는 본 발명의 융합 폴리펩티드를 코딩하는 폴리뉴클레오티드의 관점에서 상기 용어 "링커로 분리된"은 신경독소 절단 부위를 포함하는 링커가 상기 전사인자 도메인과 상기 세포질 유지 도메인 사이에 위치함을 의미한다. 따라서, 상기 융합 폴리펩티드 내에서 도메인 배열은 N-말단으로부터 C-말단으로 전사인자 도메인-링커-세포질 유지 도메인 또는 N-말단으로부터 C-말단으로 세포질 유지 도메인-링커-전사인자 도메인일 수 있다. 여기서 사용된 바와 같이, 상기 용어 "융합 폴리펩티드"는 본질적으로 다른 숙주세포 폴리펩티드가 포함되지 않은 분리된 또는 본질적으로 정제된 폴리펩티드를 포함한다. 다른 구현 예에 있어서, 상기 용어는 본 발명의 융합 폴리펩티드 및 다른 단백질을 추가적으로 포함하는 폴리펩티드 제제를 포함한다. 또한, 일 구현 예에 있어서, 상기 용어는 화학적으로 변형된 폴리펩티드를 포함한다. 이러한 변형은 인공적인 변형이거나 자연적으로 발생하는 변형일 수 있다. 본 발명의 융합 폴리펩티드는 전술된 생물학적 특징을 갖는다. 또한 일 구현 예에 있어서, 서열번호: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30 또는 31에 나타난 아미노산 서열을 포함하는 융합 폴리펩티드가 포함된다. 일 구현 예에 있어서, 본 발명의 폴리펩티드는 통상의 기술자에게 주지된 화학적 합성 또는 재조합 분자생물학 기법에 의하여 제조될 수 있다. 일 구현 예에 있어서, 본 발명의 융합 폴리펩티드를 제조하는 이러한 방법은 (a) 여기에 더욱 자세히 기술된 본 발명의 숙주세포를 배양하는 단계 및 (b) 상기 숙주세포로부터 본 발명의 융합 폴리펩티드를 수득하는 단계를 포함한다. 이러한 방법의 일 구현 예에 있어서, 상기 폴리펩티드는 숙주세포 용해물로부터 친화도 크로마토그래피, 이온 교환 크로마토그래피, 크기 배제 크로마토그래피 및/또는 예비 겔 전기영동을 포함하는 전형적인 정제기법에 의하여 수득될 수 있다. 본 발명의 융합 폴리펩티드의 일 구현 예에 있어서, 상기 융합 폴리펩티드는 정제 태그를 포함한다.
상기 용어 "정제 태그"는 이를 포함하는 폴리펩티드의 정제를 허용하는 아미노산 서열을 의미한다. 일 구현 예에 있어서, 이는 각각의 아미노산, 펩티드 서열 또는 상기 정제 기질과 물리적으로 또는 화학적으로 상호작용할 수 있는 삼차원 펩티드 구조에 의하여 구현될 수 있다. 적절한 태그로는 친화도 태그 및 에피토프 태그가 포함된다. 이러한 의미에서, 세파로오스 또는 아가로오스와 같은 적절한 기질에 박혀있는 니켈 또는 코발트와 같은 금속이온과 물리-화학적으로 상호작용할 수 있는 히스티딘과 같은 특정 아미노산이 정제에 사용될 정의된 기질을 갖는 복합체를 형성할 수 있다는 것이 주지되어 있다. 다른 펩티드 서열 또는 삼차원 구조체가 키틴 결합 단백질 (CBP), 말토오스 결합 단백질 (MBP) 또는 글루타티온-S-전이효소 (GST)에서 발견될 수 있다. 다른 구현 예에 있어서, 단백질-단백질 상호작용 기반의 정제 기질/정제 태그 시스템이 기술분야에 주지된 스트렙타비딘/비오틴 시스템과 같이 사용될 수 있다. 다른 구현 예에 있어서, 상기 태그는 형광과 같이 정제를 가능케 하는 것을 함유하는 폴리펩티드에 물리-화학적 특성을 부여할 수 있다. 이러한 관점에서 적절한 태그로는 녹색 형광 단백질 (GFP), 청색 형광 단백질 (BFP) 등과 같은 주지된 형광 단백질이 포함된다. 몇몇 기질에 내재적인 친화도를 갖는 이들 태그와 더불어, 에피토프 태그가 다른 구현 예에 적용될 수 있다. 이러한 에피토프 태그는 항체에 의해 특이적으로 인식될 수 있는 펩티드 에피토프를 구성하는 짧은 아미노산 신장체로 구성된다. 에피토프 태그는 또한 기술분야에 주지되어 있으며 FLAG 태그, MYC-태그, 또는 HA-태그를 포함한다. 따라서, 상기 정제 태그는 His-태그, Myc-태그, FLAG-태그, strep-태그, MBP-태그, NusA 태그, GST-태그, 스트렙타비딘 및 아비딘으로 이루어진 군으로부터 선택된다.
본 발명은 또한 본 발명의 폴리뉴클레오티드, 벡터 또는 융합 폴리펩티드를 포함하는 숙주세포에 관한 것이다.
여기서 사용된 바와 같이, 상기 용어 "숙주세포"는 원핵 및 진핵 숙주 세포, 바람직하게는 분리된 원핵 및 진핵 숙주세포를 포함한다. 바람직하게는, 상기 숙주세포는 진핵 숙주세포이다. 여기서 사용된 바와 같이 진핵 숙주세포는 본 발명의 융합 폴리펩티드의 생산에 적합한 동물 세포주의 세포이다. 본 발명의 폴리뉴클레오티드 또는 벡터는 상기 숙주세포의 게놈 내로 안정적으로 도입되거나 상기 숙주세포에 의하여 일시적으로 발현될 수 있다. 따라서, 여기서 사용된 바와 같이 숙주세포는 일 구현 예에 있어서, 일차 세포 또는 세포주로서 효모 세포, 인간 세포를 포함하는 포유동물 세포, 식물 세포 또는 곤충 세포를 포함한다. 바람직하게는, 상기 숙주세포는 신경세포 또는 세포주 또는 신경아세포종 세포 또는 세포주이다.
본 발명의 숙주세포의 일 구현 예에 있어서, 상기 숙주세포는 일차 신경세포, 신경아세포종 세포주, 세포주 N1E-115, 세포주 Neuro2a, 세포주 SH-SY5Y, 세포주 PC12, 세포주 SiMa, 세포주 MHH-NB-11, 세포주 SK-N-BE(2) 및 유도 만능줄기세포 (iPS), 바람직하게는 인간 만능줄기세포 (hiPS)로 이루어진 군으로부터 선택된다. 신경아세포종 세포주는 하기 ATCC 또는 DSMZ 번호: 세포주 N1E-115 CRL-2263, 세포주 Neuro2a CCL-131, 세포주 SH-SY5Y CRL-2266, 세포주 PC12 CRL-1721, 세포주 SiMa ACC 164 (DSMZ), 세포주 MHH-NB-11 ACC 157 (DSMZ) 및 세포주 SK-N-BE(2) CRL-2271 하에 ATCC 또는 DSMZ로부터 얻어진다. 세포주 SiMa의 특이적인 클론이 WO 2010/105234에 더욱 기술되어 있다. iPS 세포를 생성시키는 방법이 예를 들어, Yu et al., Science. 2009 May 8; 324(5928): 797-801. Epub 2009, WO 2011/056971 and WO 2011/025852에 기술되어 있다. 몇몇 구현 예에 있어서, iPS는 예를 들어, WO 2012/135621 및 U.S. 특허출원 US 2010/0279403 및 US 2010/0216181에 기술된 방법과 같은 적절한 방법을 이용하여 뉴런으로 분화된다.
본 발명의 숙주세포의 또 다른 구현 예에 있어서, 숙주세포는 그 발현이 상기 융합 폴리펩티드의 절단에 따라 상기 전사인자 도메인에 의하여 조절되는 리포터 유전자를 포함한다. 이러한 구현 예에 있어서, 상기 숙주세포는 리포터 유전자를 포함한다. 상기 리포터 유전자는 상기 숙주세포의 게놈 내로 안정적으로 도입되거나 상기 숙주세포에 의하여 일시적으로 발현될 수 있다. 상기 리포터 유전자의 발현은 본 발명의 융합 폴리펩티드의 신경독소에 의하여 링커 내에서 절단된 후에만 상기 전사인자 도메인에 의하여 조절된다. 리포터 유전자 분석은 공지기술로 잘 기술되어 있다 (Miraglia LJ, King FJ, Damoiseaux R: Seeing the light: luminescent reporter gene assays. Comb. Chem. High Throughput Screen 2011, 14:648-57; Fan F, Wood KV: Bioluminescent assays for high-throughput screening. Assay Drug Dev. Technol. 2007, 5:127-36). 리포터 유전자로는 예를 들어, 루시페라아제, 알칼리 포스파타아제, 서양고추냉이 과산화효소 또는 형광단백질 (GFP, YFP, RFP, CFP 등)이 사용될 수 있다.
본 발명은 또한 하기 단계:
(a) 본 발명의 융합 폴리펩티드를 포함하는 숙주 세포 및 상기 융합 폴리펩티드의 절단에 따라 그 발현이 상기 전사인자 도메인에 의하여 조절되는 리포터 유전자를 신경독소 활성을 포함하는 것으로 예상되는 샘플에 접촉시키는 단계; 및
(b) 상기 리포터 유전자 활성을 측정하는 단계;를 포함하는 샘플 내의 신경독소 활성을 결정하기 위한 방법에 관한 것이다.
여기서 기술된 리포터 유전자 분석방법은 BoNT/A와 같은 신경독소 폴리펩티드의 생물학적 활성의 결정을 촉진 및 개선 시킨다. 이러한 분석을 위하여, 본 발명의 상기 폴리뉴클레오티드, 융합 폴리펩티드, 벡터 및 숙주세포가 이용될 수 있다. 연속적으로, 활성인자 구축체 및 리포터 유전자 구축체가 여기서 기술된 숙주세포 내로 안정적으로 형질감염될 수 있다. 중독 및 SNAP-25와 같은 신경독소 폴리펩티드 기질의 절단 후에, 상기 활성인자 구축체에 포함된 트랜스활성인자 (tTA)가 상기 Tet 시스템으로부터 방출된다. 상기 리포터 유전자 내의 조절인자에 상기 트랜스활성인자가 결합하면, 루시페라아제와 같은 리포터 유전자 발현이 활성화된다. 코딩된 루시페라아제 효소의 활성은 상업적으로 구입가능한 키트를 이용하여 몇 시간 만에 검출가능하다. 산화환원반응에서 상기 루시페라아제에 의하여 매개되는 발광은 샘플 내의 신경독소 폴리펩티드의 양에 상응한다. 알려진 신경독소 폴리펩티드 농도를 갖는 표준 곡선이 참고용으로 병행하여 사용된다. 추가적인 참고용으로, 루시페라아제에 의한 신호를 각각의 경우마다 상이할 수 있는 샘플 내의 세포숫자에 대응시키기 위하여 단백질 측정이 수행될 수 있다. 이러한 방법은 기술분야에서 주지된 통상적인 방법이며 전술된 본 발명의 활성 분석과 병행하여 수행될 수 있다. 숙주세포로는 예를 들어, SIMA 세포주 (인간 신경아세포종)와 같이, 여기서 기술된 세포가 사용될 수 있다. 하기 실시 예에 나타난 바와 같이, 본 발명에 있어서 활성인자 구축체 mST01 (시냅토타그민-SNAP-25-tTA) (서열번호: 9) 및 리포터 유전자 구축체 pTRE-Luc (루시페라아제 리포터) (Clontech)를 포함하는 서브-클론된 SIMA 세포주 (SIMA 번호 3B4)로부터 SIMA 세포주의 다양한 클론이 생성되었다. 여기서 기술된 바와 같이 리포터 유전자 분석에 사용될 수 있는 리포터 유전자는 공지기술로 주지되어 있으며, 예를 들어, 접근번호 P08659, Q27758, H1AD96, A3KC01, A3KC00, A3KBZ9, A3KBZ8, A3KBZ7, A3KBZ6, A3KBZ5, D5MS63, Q2TNU5, Q5UFR2, Q2VL10, Q6SVE0, B5A991, Q27688, A1Z0H9, Q207B1, Q5USC8, G9M6I8, Q6SVE2, Q9GPF9, 또는 Q6SVE1로 나타난 서열을 포함한다.
활성인자 구축체 mST01 (시냅토타그민-SNAP-25-tTA) (서열번호: 9) 및 리포터 유전자 구축체 pTRE-Luc (루시페라아제 리포터 (Clontech)를 포함하는 전술된 클론은 상기 활성인자 및 리포터 구축체를 상기 게놈 내로 안정적으로 운반한다. 또한, 모 SIMA 세포 즉, 서브-클론되지 않은 배아 조직으로부터 유래된 인간 다능성 세포 및 상업적으로 구입가능한 P19 세포주 (쥐 배아 암종)가 본 발명의 전술된 구축체로 일시적인 형질감염 또는 안정적인 형질감염 모두의 형질감염을 위하여 또한 사용될 수 있다. 바람직하게는, 상기 형질감염 (transfection)은 안정적인 형질감염이다. 따라서, 전술된 바와 같이 생성된 신규한 이중-형질전환 세포주는 신경독소 폴리펩티드의 생물학적 활성의 측정을 위한 개선된 분석을 가능케 한다. 그 결과, 상기 신경독소 폴리펩티드 활성의 결정을 위한 분석의 민감도가 증가될 수 있다. 또한, 본 발명의 분석법은 기술분야에 개시된 분석법과 비교하여 시간 및 비용이 절약된다. 본 발명의 상기 분석법은 예를 들어 성인의 이틀 작업시간이 요구되는 고된 방법인 웨스턴 블롯팅과 같이 기술분야에서 개시된 신경독소 폴리펩티드의 생물학적 활성을 검출하기 위한 방법에 대한 대체수단을 제공한다.
본 발명의 방법은 자동화에 의하여 보조될 수 있다. 특히, 일 구현 예에 있어서, 상기 단계 a) 및/또는 b)가 화합물을 혼합하고 상기 리포터 유전자 활성을 측정하기 위하여 로봇 장치 및 자동화된 판독시스템에 의하여 보조될 수 있다. 적절한 시스템은 공지 기술로 알려져 있으며 결정될 반응의 유형에 의존한다. 또한, 상기 방법은 샘플 제조 및 본 발명의 융합 폴리펩티드의 생성과 관련한 추가적인 단계를 포함할 수 있다.
여기서 사용된 바와 같이, 상기 용어 "접촉시키는"은 화합물의 물리적 및/또는 화학적 상호작용이 가능하도록 적어도 두 개의 상이한 화합물을 물리적으로 가까이 두는 것을 의미한다. 전술된 방법으로, 본 발명의 융합 폴리펩티드와 그 발현이 상기 융합 폴리펩티드의 절단에 따라 상기 전사인자 도메인에 의하여 조절되는 리포터 유전자를 포함하는 숙주세포가 신경독소 활성을 포함하는 것으로 여겨지는 샘플과 접촉된다. 상기 접촉은 상기 샘플에 포함된 신경독소 폴리펩티드에 의하여 본 발명의 융합 폴리펩티드의 링커 내의 신경독소 절단 부위의 절단을 허용하기에 충분한 시간 동안 및 조건 하에서 이루어질 수 있다. 일 구현 예에 있어서, 여기서 사용된 바와 같이 접촉은 본 발명의 융합 폴리펩티드를 함유하는 본 발명의 숙주세포 내에서 이루어진다. 따라서, 일 구현 예에 있어서 상기 폴리펩티드는 숙주세포, 일 구현 예에 있어서는 본 발명의 숙주세포에 포함된다. 상기 시간 및 조건은 상기 샘플에 포함된 신경독소 폴리펩티드의 양과 상기 숙주세포에 의한 상기 신경독소 폴리펩티드의 흡수에 의존적일 것이다. 통상의 기술자에게 숙주세포, 샘플의 종류, 및 결정될 신경독소의 종류에 따라 적용될 필요가 있는 조건이 무엇인지가 잘 알려져 있다. 이러한 관점에서, 접촉은 본 발명의 융합 폴리펩티드를 포함하는 세포 시스템 내에서 일어난다. 상기 세포 시스템은 상기 시스템을 상기 샘플과 접촉시킴에 따라 상기 신경독소의 활성을 측정하는 것을 가능케 하며, 이에 따라 상기 샘플 내의 신경독소 단백질분해효소 활성을 결정하는 것을 가능케 한다. 상기 용어 "샘플"은 신경독소 폴리펩티드를 포함하는 것으로 여겨지는 샘플을 의미한다. 일 구현 예에 있어서, 상기 샘플은 수용액이다. 이러한 샘플은 생물학적 샘플이거나 또는 인공적으로 생성된 수용액 샘플일 수 있다. 일 구현 예에 있어서, 이러한 용액은 품질관리 및/또는 활성 결정/구체화 목적 또는 안전 관리에 대한 신경독소 제조 과정에서 서로 상이한 단계에서 얻어진다. 상기 샘플 내에 존재하는 신경독소는 적어도 신경독소 단백질분해효소 활성을 나타낼 것이라고 여겨진다. 일 구현 예에 있어서, 상기 신경독소는 완전히 생물학적으로 활성이다. 일 구현 예에 있어서, 상기 완전히 생물학적으로 활성인 신경독소는 상기 세포를 집어넣고 본 발명의 융합 폴리펩티드에 기초한 판독을 활성화시키기 위하여 요구된다. 따라서, 만약 본 발명의 방법에 의하여 분석될 샘플과 숙주세포가 접촉되는 경우라면, 이러한 완전히 생물학적으로 활성인 신경독소가 적용될 것이다. 다른 구현 예에 있어서, 본 발명의 방법에 적용될 샘플은 신경독소 폴리펩티드 또는 신경독소 단백질분해효소 활성을 단지 나타내는 이의 단편을 포함한다. 일 구현 예에 있어서, 이러한 신경독소 폴리펩티드 또는 단편은 단백질 분해적으로 활성인 경쇄를 포함하거나 또는 실질적으로 이로 이루어진 신경독소 폴리펩티드의 돌연변이 단백질이다.
일 구현 예에 있어서, 상기 리포터 유전자 활성은 리포터 유전자 기질의 효소적 전환 (enzymatic conversion)을 측정함으로써 결정된다. 일 구현 예에 있어서 상기 후자는 전환 반응 동안 방출되는 빛의 강도를 검출함으로써 측정될 수 있다. 리포터 유전자에 의하여 촉매되는 전환 반응 동안 일어나는 발광을 측정하는 적절한 시스템은 기술분야에 주지되어 있으며 상업적으로 구입가능하다. 또한, 상기 리포터 유전자에 사용될 수 있는 적절한 기질도 주지되어 있으며 상업적으로 구입가능하다.
샘플 내의 신경독소 폴리펩티드는 정량적으로 또는 정성적으로 결정될 수 있다. 본 발명의 일 구현 예에 있어서, 정성적 결정을 위하여 신경독소 폴리펩티드의 존재 또는 부존재가 결정된다. 본 발명의 일 구현 예에 있어서, 정량적 검출을 위하여 상기 신경독소 폴리펩티드의 양이 결정된다. 일 구현 예에 있어서, 상기 정량적 결정은 절대량 또는 상대량 즉, 상이한 샘플에서 밝혀진 양이 서로에 대하여 비교될 수 있도록 규준화된 양의 결정을 포함한다. 일 구현 예에 있어서, 이는 미리 결정된 양의 상기 신경독소 폴리펩티드를 갖는 조정 샘플을 본 발명의 방법에 적용함으로써 구축되는 조정 곡선과 테스트 샘플에 대하여 측정된 리포터 유전자 활성을 비교함으로써 구현될 수 있다.
본 발명의 방법의 일 구현 예에 있어서, 상기 숙주세포는 여기서 정의된 숙주세포이다.
본 발명은 또한 본 발명의 폴리뉴클레오티드, 벡터, 융합 폴리펩티드 또는 숙주세포를 샘플 내의 신경독소 활성을 결정하기 위하여 사용하는 용도에 관한 것이다.
마지막으로, 본 발명은 본 발명의 폴리뉴클레오티드, 벡터, 융합 폴리펩티드 또는 숙주세포 및 바람직하게는, 리포터 유전자 활성을 검출하기 위한 검출 제제를 포함하는 신경독소 활성을 결정하기 위한 키트에 관한 것이다.
여기서 사용된 바와 같이, 상기 용어 "키트"는 본 발명의 방법을 수행하기 위해 준비되어 있는 방식으로 분리된 또는 공통된 바이얼 내에 제공되는 본 발명의 융합 폴리펩티드, 폴리뉴클레오티드, 벡터 및/또는 숙주세포를 포함하는 수단의 집합체를 의미한다. 일 구현 예에 있어서, 상기 키트는 예를 들어, 정의된 생물학적 활성을 갖는 신경독소 폴리펩티드를 포함하는 조정 표준 용액 및/또는 상기 리포터 유전자에 의하여 전환된 리포터 유전자 또는 기질에 대한 검출 제제와 같은 상기 리포터 유전자 활성을 측정하기 위한 수단과 같은 본 발명의 방법을 수행하기 위한 추가적인 수단을 포함한다. 또한, 일 구현 예에 있어서, 상기 키트는 본 발명의 방법을 수행하기 위한 지침서를 포함한다. 이들 지침서는 매뉴얼로 제공되거나 또는 본 발명의 방법의 하나 이상의 단계를 통제할 수 있는 데이터 저장 매체 상의 컴퓨터로 수행될 수 있는 알고리즘의 형태일 수 있다. 일 구현 예에 있어서, 상기 키트는 구체적으로 전술된 본 발명의 방법을 수행하기 위하여 사용될 수 있다.
여기에 인용된 모든 참조들은 상기 전체 개시 내용 및 여기에 구체적으로 언급된 개시 내용에 관하여 참조로 포함된다.
도면
도 1은 활성인자-구축체를 구축하기 위한 기본으로 사용된 Clontech사에 의해 제공된 본래의 조절 플라스미드 (a); 루시페라아제-코딩 리포터 구축체 (b); 루시페라아제-리포터 구축체를 위한 시스템 조절 플라스미드 (c)를 나타낸다 (모두 Clontech사).
도 2는 pCMV-Tet3G-벡터 (도 1a)를 골격으로 갖는 활성인자-플라스미드 mST01 (서열번호: 9) 구축의 일례를 나타낸다. 시냅토타그민 (87개의 아미노산)의 N-말단 막고정 도메인 및 SNAP25의 112개의 C-말단 아미노산을 포함하는 본 발명의 폴리뉴클레오티드가 계획된 EcoRⅠ 및 XbaⅠ절단 부위를 통하여 클로닝된다. 상기 벡터의 주요 특징이 화살표로 강조표시되어 있고 또한 그 위치를 (염기쌍 (bp)으로) 나타내는 우측 표에 나타나 있다.
도 3은 활성인자 및 리포터 구축체의 안정적인 도입에 관한 대조구로서 게놈 PCR의 결과를 나타낸다. 루시페라아제에 관해 설계된 프라이머는 ~1kb의 산물을 생산하며, Tet-인자에 관한 프라이머는 ~0.5kb의 산물을 생산한다. 강조 표시된 레인은 안정적으로 도입된 두 플라스미드 클론을 나타낸다. 전체적으로, 상기 게놈 PCR의 결과에 기초하여 24개의 생성된 클론 중 10개가 루시페라아제 및 Tet-인자에 대하여 양성이었다.
도 4는 시냅토타그민-SNAP25 융합 단백질의 막고정 구축체를 보여주는 묘사된 예시의 작용 방법의 모식도를 나타낸다.
약어 및 기호:
SYT: 시냅토타그민 (Synaptotagmin);
tetR: 테트라사이클린 억제인자 (Tetracycline-Repressor);
VP16: 단순 포진 VP16 단백질의 전사활성 도메인;
CMV: 거대세포 바이러스 (Cytomegalie virus) 프로모터;
검은색 사각형: 독시사이클린 (Doxycycline).
상기 융합 단백질은 구성적으로 (constitutively) 발현되며 바람직하게는 신경 분화 세포의 말단 가지의 막에 연결된다. 각각의 링커 도메인 내에서 BoNT의 절단에 따라, TetR-인자 및 VP16로 구성된 복합체가 상기 핵 내로 운반된다. 항생제 독시사이클린이 존재하는 경우, 상기 TetR-인자/VP16의 Tet-프로모터 및 이에 따라 그 조절된 리포터 유전자 루시페라아제에의 결합을 허용하는 구조적 변화가 야기된다. 루시페라아제의 유도된 발현에 따라, 상업적으로 구입가능한 분석 키트를 이용하여 그 효소적 활성을 검출하고 정량하는 것은 기능적 판독이다. 이는 또한 모든 막고정 구축체에 적용될 수 있다. 시토졸 활성인자 구축체에 있어서, 위치화는 상기 세포 내에서 바람직한 도메인에 국한되지 않는다. TetR-인자의 핵 내로의 기본적인 운반 기작 및 상기 리포터의 연속적인 발현/검출의 활성화는 지속적이다.
실시 예
이하, 제한적이지 않고 단지 본 발명을 상세히 기술하는 것일 뿐 그 범주를 한정하는 것으로 해석되어서는 아니 되는 하기 실시 예에 의하여 본 발명이 기술될 것이다.
제한 희석을 이용하여 서브클로닝함으로써 모 SiMa 세포주 (DSMZ, 접근 번호: ACC-164)로부터 유래된 서브-클론된 SiMa 세포주 (SIMA 번호 3B4)가 Xfect 형질감염 제제 및 판매자 (Clontech Laboratories, Inc., Cat. No.: 631317)에 의하여 제공된 수반된 산물을 이용하여 안정적으로 형질감염되었다. 형질감염 세포가 90% 컨플루언시 (confluency)를 나타내었을 때, 6-웰 플레이트에서 형질감염을 수행하였다. 상기 각각의 폴리뉴클레오티드-DNA가 웰 당 2㎍으로 사용되었다. 루시페라아제-리포터-구축체로 형질감염시키는 경우, 상기 DNA는 히그로마이신 (Hygromycin)에 대하여 0.1㎍ 선형 선별 마커 (20:1 비율)를 수반하였다. 4시간 후에, 형질감염 기질을 함유하는 배지를 정상적인 성장 배지로 대체하였다.
이러한 배지 교체 24시간 후에, 동일한 제제의 두 개의 6-웰이 채워지고 PDL-코팅된 페트리 접시 (Φ14.5㎝) 상에 놓였으며, 단일 콜로니가 형성될 때까지 항생제 선별 (G418: 400㎍/㎖; 히그로마이신: 150㎍/㎖)이 수행되기 전에, (밀도가 70 내지 80% 컨플루언시에 이를 때까지) 최소 48시간 동안 성장시켰다. 이들 단일 콜로니를 선택하여 확장시키고 관심 있는 각각의 구축체의 안정적인 게놈 도입에 관하여 테스트하였다. 선별기간 후에 항생제 농도를 G418: 200㎍/㎖ 및 히그로마이신: 100㎍/㎖로 낮추었다.
Tet-인자 (전방: AGCTGGGAGTTGAGCAGCCTAC (서열번호: 35); 후방: GGTGCCGAGATGCACTTTAGCC (서열번호: 36)) 및 루시페라아제 리포터 (전방: GAAGAGATACGCCCTGGTTC (서열번호: 37); 후방: CGGGAGGTAGATGAGATGTG (서열번호: 38))에 대한 특이적인 프라이머를 이용하고 Phusion 고 신뢰도 키트 (NEB)를 적용하여 연속적인 아가로오스 겔 전기영동에 의한 프로토콜 및 분석에 따른 게놈 PCR (Lyse 및 Go PCR 제제를 이용하여, Thermo Scientific 프로토콜에 따라 세포를 용해시킴).
두 개의 구축체의 삽입에 대하여 양성적으로 테스트된 후에, 세포를 확장시키고 액체 질소 탱크 내에 세포 은행 저장물을 생성시켰다. 실험용 세포를 사용하기 전에, 저장물의 재-해동 후 안정적인 삽입에 관한 테스트를 수행하였다.
우선, 구축체 mST01 (시냅토타그민-SNAP-25-tTA) (서열번호: 9)를 형질감염시켰으며, 가능한 유전적 변이가 적은 클론 배경 (clonal background)에 이르도록 단일 세포 서브클로닝을 수행하였다. 이들 안정적인 클론을 리포터 유전자 구축체 pTRE-Luc (루시페라아제 리포터)로 두 번째 형질감염시켰고, 연속적인 단일 세포 클로닝을 반복하였다 (도 3). 각각의 GOI를 갖지 않으며 전술된 특성에 있어서 어떠한 손상도 나타내지 않은 공 (empty) 벡터 (활성인자 대조구 플라스미드로서 pCMV-Tet3G 및 리포터 대조구 플라스미드로서 pTRE3G)를 이용하여, 형질감염적이고, 생존가능하며 기능적인 대조구를 제조하였다 (도 1a, c) (Clontech).
도입 안정성을 나타낸 후, Tet-인자의 발현 분석 및 신경독소에 의한 BoNT 링커-도메인의 절단이 평가되었다. 이러한 실험에 있어서, 이중 형질감염된 클론이 PDL-코팅된 96-웰 플레이트 상에 도포되었고, WO 2010/105234에 개시된 절차에 따라 신경 표현형으로 분화되었다. 24-72 시간 동안 세포 배양에서 1×10-10M 내지 10×10-14M 범위의 최종 농도를 갖는 연속 농도를 이용하여 BoNT/A로의 중독이 수행되었다. 0.2% 인간 혈청 알부민으로 보충된 DPBS 내에서 BoNT의 저장물 연속 희석이 수행되었으며, 대응적이고 직접적으로 상기 세포 배양 배지 내로 적용되었다. 중독 후에, Tet-억제인자 단백질의 방출이 검출되고 본래의 폴리펩티드 서열과 구분가능할 것이다. Tet-온 (Tet-on) 시스템으로서 독시사이클린에 대한 시간 및 투여량 반응 수준이 기본으로 사용되었을 뿐만 아니라, 루시페라아제 리포터의 발현 수준이 BoNT에 대한 시간 및 투여량-반응에서 더욱 분석되었다. 상업적으로 이용가능한 루시페라아제-분석-키트를 이용함으로써 기능적 판독이 수행되었다. 이 경우, 두 개의 상이한 키트가 적용될 수 있으며, 주로 순수한 기능적 판독을 위하여는 순수 루시페라아제 분석 시스템 (One-Glo, Promega)을 사용하고, 완전한 분석 적용을 위해서는 세포 생존능 평가 (One-Glo+Tox, Promega)와 조합으로 루시페라아제 분석 시스템을 사용가능하다. 이러한 다중 접근은 동일한 샘플 내의 규준화 및 기능적 데이터를 가능하게 하며, 따라서 상기 분석의 확립을 위한 확고한 기초를 마련할 수 있다.
SEQUENCE LISTING
<110> Merz Pharma GmbH & Co. KGaA
<120> Means and methods for determination of Botulinum neurotoxin
biological activity
<130> MP10485PC
<160> 38
<170> PatentIn version 3.3
<210> 1
<211> 3258
<212> DNA
<213> artificial
<220>
<223> SV2-SNAP25-tTA (2)(pcDNA3.1)
<400> 1
gctagcgcca ccatggaaga ctcttacaag gataggactt cactgatgaa gggtgccaag 60
gacattgcca gagaggtgaa gaaacaaaca gtaaagaagg tgaatcaagc tgtggaccga 120
gcccaggatg aatacaccca gaggtcctac agtcggttcc aagatgaaga agatgatgat 180
gactactacc cggctggaga aacctataat ggtgaggcca acgatgacga aggctcaagt 240
gaagccactg aggggcatga tgaagatgat gagatctatg agggggagta tcagggcatc 300
cccagtatga accaagcgaa ggacagcatc gtgtcagtgg ggcagcccaa gggcgatgag 360
tacaaggacc gacgggagct ggaatcagaa aggagagctg acgaggaaga gttagcccag 420
cagtatgagc tgataatcca agaatgcggt catggtcgtt ttcagtgggc ccttttcttc 480
gtcctgggca tggctcttat ggcagacggt gtagaggtgt ttgtcgttgg cttcgtgtta 540
cccagtgctg agacagacct ctgcatccca aattcaggat ctggatggct aggcagcata 600
gtgtacctcg ggatgatggt gggggcgttc ttctggggag gactggcaga caaagtggga 660
aggaaacagt ctcttctgat ttgcatgtct gtcaacggat tctttgcctt cctttcttca 720
tttgtccaag gttatggctt ctttctcttc tgtcgcttac tttctggatt cgggattgga 780
ggagccatac ccactgtgtt ctcgtacttt gctgaagtcc tggcccggga aaagcggggc 840
gaacacttga gctggctctg catgttctgg atgatcggtg gcatctacgc ctctgccatg 900
gcctgggcca tcatcccgca ctacgggtgg agcttcagca tgggatcggc ctaccagttt 960
cacagttggc gtgtgtttgt catcgtctgt gcactcccct gtgtctcctc cgtggtggcc 1020
ctcacattca tgcctgaaag cccacgattc ttgttggagg ttggaaaaca tgatgaagct 1080
tggatgattc tgaagttaat tcatgacacc aacatgagag cccggggtca gcctgagaag 1140
gtcttcacgg taaacaaaat aaaaactcct aaacaaatag atgagctgat tgaaattgag 1200
agtgacacag gaacatggta taggaggtgt tttgttcgga tccgcaccga gctgtacgga 1260
atttggttga cttttatgag atgtttcaac tacccagtca gggataatac aataaagctt 1320
acaattgttt ggttcaccct gtcctttggg tactatggat tatccgtttg gttccctgat 1380
gtcattaaac ctctgcagtc cgatgaatat gcattgctaa ccagaaatgt ggagagagat 1440
aaatatgcaa atttcactat taactttaca atggaaaatc agattcatac tggaatggaa 1500
tacgacaatg gcagattcat aggggtcaag ttcaaatctg taactttcaa agactctgtt 1560
tttaagtcct gcacctttga ggatgtaact tcagtgaaca cctacttcaa gaactgcaca 1620
tttattgaca ctgtttttga caacacagat tttgagccat ataaattcat tgacagtgaa 1680
tttaaaaact gctcgttttt tcacaacaag acgggatgtc agattacctt tgatgatgac 1740
tatagtgcct actggattta ttttgtcaac tttctgggga cattggcagt attgccaggg 1800
aacattgtgt ctgctctgct gatggacaga attgggcgct taacaatgct aggtggctct 1860
atggtgcttt cggggatcag ctgtttcttc ctttggttcg gcaccagtga atccatgatg 1920
ataggcatgc tgtgtctgta caatggattg accatctcag cctggaactc tcttgacgtg 1980
gtcactgtgg aactgtaccc cacagaccgg agggcaacag gctttggctt cttaaatgcg 2040
ctatgcaagg cagcagccgt cctgggaaac ttaatatttg gctctctggt cagcatcacc 2100
aaatcaatcc ccatcctgct ggcttctact gtgctcgtgt gtggaggact cgttgggctg 2160
tgcctgcctg acacacgatc aagtgatgct tacaaaaaag cctggggcaa taatcaggac 2220
ggagtggtgg ccagccagcc tgctcgtgta gtggacgaac gggagcagat ggccatcagt 2280
ggcggcttca tccgcagggt aacaaatgat gcccgagaaa atgaaatgga tgaaaaccta 2340
gagcaggtga gcggcatcat cgggaacctc cgtcacatgg ccctggatat gggcaatgag 2400
atcgatacac agaatcgcca gatcgacagg atcatggaga aggctgattc caacaaaacc 2460
agaattgatg aggccaacca acgtgcaaca aagatgctgg gaagtggttc tagactggac 2520
aagagcaaag tcataaactc tgctctggaa ttactcaatg gagtcggtat cgaaggcctg 2580
acgacaagga aactcgctca aaagctggga gttgagcagc ctaccctgta ctggcacgtg 2640
aagaacaagc gggccctgct cgatgccctg ccaatcgaga tgctggacag gcatcatacc 2700
cactcctgcc ccctggaagg cgagtcatgg caagactttc tgcggaacaa cgccaagtca 2760
taccgctgtg ctctcctctc acatcgcgac ggggctaaag tgcatctcgg cacccgccca 2820
acagagaaac agtacgaaac cctggaaaat cagctcgcgt tcctgtgtca gcaaggcttc 2880
tccctggaga acgcactgta cgctctgtcc gccgtgggcc actttacact gggctgcgta 2940
ttggaggaac aggagcatca agtagcaaaa gaggaaagag agacacctac caccgattct 3000
atgcccccac ttctgaaaca agcaattgag ctgttcgacc ggcagggagc cgaacctgcc 3060
ttccttttcg gcctggaact aatcatatgt ggcctggaga aacagctaaa gtgcgaaagc 3120
ggcgggccga ccgacgccct tgacgatttt gacttagaca tgctcccagc cgatgccctt 3180
gacgactttg accttgatat gctgcctgct gacgctcttg acgattttga ccttgacatg 3240
ctccccgggt aactcgag 3258
<210> 2
<211> 1079
<212> PRT
<213> artificial
<220>
<223> SV2-SNAP25-tTA (2)(pcDNA3.1)
<400> 2
Met Glu Asp Ser Tyr Lys Asp Arg Thr Ser Leu Met Lys Gly Ala Lys
1 5 10 15
Asp Ile Ala Arg Glu Val Lys Lys Gln Thr Val Lys Lys Val Asn Gln
20 25 30
Ala Val Asp Arg Ala Gln Asp Glu Tyr Thr Gln Arg Ser Tyr Ser Arg
35 40 45
Phe Gln Asp Glu Glu Asp Asp Asp Asp Tyr Tyr Pro Ala Gly Glu Thr
50 55 60
Tyr Asn Gly Glu Ala Asn Asp Asp Glu Gly Ser Ser Glu Ala Thr Glu
65 70 75 80
Gly His Asp Glu Asp Asp Glu Ile Tyr Glu Gly Glu Tyr Gln Gly Ile
85 90 95
Pro Ser Met Asn Gln Ala Lys Asp Ser Ile Val Ser Val Gly Gln Pro
100 105 110
Lys Gly Asp Glu Tyr Lys Asp Arg Arg Glu Leu Glu Ser Glu Arg Arg
115 120 125
Ala Asp Glu Glu Glu Leu Ala Gln Gln Tyr Glu Leu Ile Ile Gln Glu
130 135 140
Cys Gly His Gly Arg Phe Gln Trp Ala Leu Phe Phe Val Leu Gly Met
145 150 155 160
Ala Leu Met Ala Asp Gly Val Glu Val Phe Val Val Gly Phe Val Leu
165 170 175
Pro Ser Ala Glu Thr Asp Leu Cys Ile Pro Asn Ser Gly Ser Gly Trp
180 185 190
Leu Gly Ser Ile Val Tyr Leu Gly Met Met Val Gly Ala Phe Phe Trp
195 200 205
Gly Gly Leu Ala Asp Lys Val Gly Arg Lys Gln Ser Leu Leu Ile Cys
210 215 220
Met Ser Val Asn Gly Phe Phe Ala Phe Leu Ser Ser Phe Val Gln Gly
225 230 235 240
Tyr Gly Phe Phe Leu Phe Cys Arg Leu Leu Ser Gly Phe Gly Ile Gly
245 250 255
Gly Ala Ile Pro Thr Val Phe Ser Tyr Phe Ala Glu Val Leu Ala Arg
260 265 270
Glu Lys Arg Gly Glu His Leu Ser Trp Leu Cys Met Phe Trp Met Ile
275 280 285
Gly Gly Ile Tyr Ala Ser Ala Met Ala Trp Ala Ile Ile Pro His Tyr
290 295 300
Gly Trp Ser Phe Ser Met Gly Ser Ala Tyr Gln Phe His Ser Trp Arg
305 310 315 320
Val Phe Val Ile Val Cys Ala Leu Pro Cys Val Ser Ser Val Val Ala
325 330 335
Leu Thr Phe Met Pro Glu Ser Pro Arg Phe Leu Leu Glu Val Gly Lys
340 345 350
His Asp Glu Ala Trp Met Ile Leu Lys Leu Ile His Asp Thr Asn Met
355 360 365
Arg Ala Arg Gly Gln Pro Glu Lys Val Phe Thr Val Asn Lys Ile Lys
370 375 380
Thr Pro Lys Gln Ile Asp Glu Leu Ile Glu Ile Glu Ser Asp Thr Gly
385 390 395 400
Thr Trp Tyr Arg Arg Cys Phe Val Arg Ile Arg Thr Glu Leu Tyr Gly
405 410 415
Ile Trp Leu Thr Phe Met Arg Cys Phe Asn Tyr Pro Val Arg Asp Asn
420 425 430
Thr Ile Lys Leu Thr Ile Val Trp Phe Thr Leu Ser Phe Gly Tyr Tyr
435 440 445
Gly Leu Ser Val Trp Phe Pro Asp Val Ile Lys Pro Leu Gln Ser Asp
450 455 460
Glu Tyr Ala Leu Leu Thr Arg Asn Val Glu Arg Asp Lys Tyr Ala Asn
465 470 475 480
Phe Thr Ile Asn Phe Thr Met Glu Asn Gln Ile His Thr Gly Met Glu
485 490 495
Tyr Asp Asn Gly Arg Phe Ile Gly Val Lys Phe Lys Ser Val Thr Phe
500 505 510
Lys Asp Ser Val Phe Lys Ser Cys Thr Phe Glu Asp Val Thr Ser Val
515 520 525
Asn Thr Tyr Phe Lys Asn Cys Thr Phe Ile Asp Thr Val Phe Asp Asn
530 535 540
Thr Asp Phe Glu Pro Tyr Lys Phe Ile Asp Ser Glu Phe Lys Asn Cys
545 550 555 560
Ser Phe Phe His Asn Lys Thr Gly Cys Gln Ile Thr Phe Asp Asp Asp
565 570 575
Tyr Ser Ala Tyr Trp Ile Tyr Phe Val Asn Phe Leu Gly Thr Leu Ala
580 585 590
Val Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp Arg Ile Gly
595 600 605
Arg Leu Thr Met Leu Gly Gly Ser Met Val Leu Ser Gly Ile Ser Cys
610 615 620
Phe Phe Leu Trp Phe Gly Thr Ser Glu Ser Met Met Ile Gly Met Leu
625 630 635 640
Cys Leu Tyr Asn Gly Leu Thr Ile Ser Ala Trp Asn Ser Leu Asp Val
645 650 655
Val Thr Val Glu Leu Tyr Pro Thr Asp Arg Arg Ala Thr Gly Phe Gly
660 665 670
Phe Leu Asn Ala Leu Cys Lys Ala Ala Ala Val Leu Gly Asn Leu Ile
675 680 685
Phe Gly Ser Leu Val Ser Ile Thr Lys Ser Ile Pro Ile Leu Leu Ala
690 695 700
Ser Thr Val Leu Val Cys Gly Gly Leu Val Gly Leu Cys Leu Pro Asp
705 710 715 720
Thr Arg Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp
725 730 735
Gly Val Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln
740 745 750
Met Ala Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg
755 760 765
Glu Asn Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly
770 775 780
Asn Leu Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln
785 790 795 800
Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr
805 810 815
Arg Ile Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly
820 825 830
Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu
835 840 845
Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys
850 855 860
Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg
865 870 875 880
Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His Thr
885 890 895
His Ser Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn
900 905 910
Asn Ala Lys Ser Tyr Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala
915 920 925
Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu
930 935 940
Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn
945 950 955 960
Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val
965 970 975
Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro
980 985 990
Thr Thr Asp Ser Met Pro Pro Leu Leu Lys Gln Ala Ile Glu Leu Phe
995 1000 1005
Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu
1010 1015 1020
Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly
1025 1030 1035
Pro Thr Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala
1040 1045 1050
Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala
1055 1060 1065
Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly
1070 1075
<210> 3
<211> 2814
<212> DNA
<213> artificial
<220>
<223> SV2-SNAP25-tTA (3)(pCMV-Tet3G)
<400> 3
gaattcacca tggaagactc ttacaaggat aggacttcac tgatgaaggg tgccaaggac 60
attgccagag aggtgaagaa acaaacagta aagaaggtga atcaagctgt ggaccgagcc 120
caggatgaat acacccagag gtcctacagt cggttccaag atgaagaaga tgatgatgac 180
tactacccgg ctggagaaac ctataatggt gaggccaacg atgacgaagg ctcaagtgaa 240
gccactgagg ggcatgatga agatgatgag atctatgagg gggagtatca gggcatcccc 300
agtatgaacc aagcgaagga cagcatcgtg tcagtggggc agcccaaggg cgatgagtac 360
aaggaccgac gggagctgga atcagaaagg agagctgacg aggaagagtt agcccagcag 420
tatgagctga taatccaaga atgcggtcat ggtcgttttc agtgggccct tttcttcgtc 480
ctgggcatgg ctcttatggc agacggtgta gaggtgtttg tcgttggctt cgtgttaccc 540
agtgctgaga cagacctctg catcccaaat tcaggatctg gatggctagg cagcatagtg 600
tacctcggga tgatggtggg ggcgttcttc tggggaggac tggcagacaa agtgggaagg 660
aaacagtctc ttctgatttg catgtctgtc aacggattct ttgccttcct ttcttcattt 720
gtccaaggtt atggcttctt tctcttctgt cgcttacttt ctggattcgg gattggagga 780
gccataccca ctgtgttctc gtactttgct gaagtcctgg cccgggaaaa gcggggcgaa 840
cacttgagct ggctctgcat gttctggatg atcggtggca tctacgcctc tgccatggcc 900
tgggccatca tcccgcacta cgggtggagc ttcagcatgg gatcggccta ccagtttcac 960
agttggcgtg tgtttgtcat cgtctgtgca ctcccctgtg tctcctccgt ggtggccctc 1020
acattcatgc ctgaaagccc acgattcttg ttggaggttg gaaaacatga tgaagcttgg 1080
atgattctga agttaattca tgacaccaac atgagagccc ggggtcagcc tgagaaggtc 1140
ttcacggtaa acaaaataaa aactcctaaa caaatagatg agctgattga aattgagagt 1200
gacacaggaa catggtatag gaggtgtttt gttcggatcc gcaccgagct gtacggaatt 1260
tggttgactt ttatgagatg tttcaactac ccagtcaggg ataatacaat aaagcttaca 1320
attgtttggt tcaccctgtc ctttgggtac tatggattat ccgtttggtt ccctgatgtc 1380
attaaacctc tgcagtccga tgaatatgca ttgctaacca gaaatgtgga gagagataaa 1440
tatgcaaatt tcactattaa ctttacaatg gaaaatcaga ttcatactgg aatggaatac 1500
gacaatggca gattcatagg ggtcaagttc aaatctgtaa ctttcaaaga ctctgttttt 1560
aagtcctgca cctttgagga tgtaacttca gtgaacacct acttcaagaa ctgcacattt 1620
attgacactg tttttgacaa cacagatttt gagccatata aattcattga cagtgaattt 1680
aaaaactgct cgttttttca caacaagacg ggatgtcaga ttacctttga tgatgactat 1740
agtgcctact ggatttattt tgtcaacttt ctggggacat tggcagtatt gccagggaac 1800
attgtgtctg ctctgctgat ggacagaatt gggcgcttaa caatgctagg tggctctatg 1860
gtgctttcgg ggatcagctg tttcttcctt tggttcggca ccagtgaatc catgatgata 1920
ggcatgctgt gtctgtacaa tggattgacc atctcagcct ggaactctct tgacgtggtc 1980
actgtggaac tgtaccccac agaccggagg gcaacaggct ttggcttctt aaatgcgcta 2040
tgcaaggcag cagccgtcct gggaaactta atatttggct ctctggtcag catcaccaaa 2100
tcaatcccca tcctgctggc ttctactgtg ctcgtgtgtg gaggactcgt tgggctgtgc 2160
ctgcctgaca cacgaaccca ggttctgatg gccgaagacg cagacatgcg caatgagctg 2220
gaggagatgc agcgaagggc tgaccagttg gctgatgagt cgctggaaag cacccgtcgt 2280
atgctgcaac tggttgaaga gagtaaagat gctggtatca ggactttggt tatgttggat 2340
gaacaaggag aacaactgga acgcattgag gaagggatgg accaaatcaa taaggacatg 2400
aaagaagcag aaaagaattt gacggaccta ggaaaattct gcgggctttg tgtgtgtccc 2460
tgtaacaagc ttaaatcaag tgatgcttac aaaaaagcct ggggcaataa tcaggacgga 2520
gtggtggcca gccagcctgc tcgtgtagtg gacgaacggg agcagatggc catcagtggc 2580
ggcttcatcc gcagggtaac aaatgatgcc cgagaaaatg aaatggatga aaacctagag 2640
caggtgagcg gcatcatcgg gaacctccgt cacatggccc tggatatggg caatgagatc 2700
gatacacaga atcgccagat cgacaggatc atggagaagg ctgattccaa caaaaccaga 2760
attgatgagg ccaaccaacg tgcaacaaag atgctgggaa gtggttaatc taga 2814
<210> 4
<211> 1179
<212> PRT
<213> artificial
<220>
<223> SV2-SNAP25-tTA (3)(pCMV-Tet3G)
<400> 4
Met Glu Asp Ser Tyr Lys Asp Arg Thr Ser Leu Met Lys Gly Ala Lys
1 5 10 15
Asp Ile Ala Arg Glu Val Lys Lys Gln Thr Val Lys Lys Val Asn Gln
20 25 30
Ala Val Asp Arg Ala Gln Asp Glu Tyr Thr Gln Arg Ser Tyr Ser Arg
35 40 45
Phe Gln Asp Glu Glu Asp Asp Asp Asp Tyr Tyr Pro Ala Gly Glu Thr
50 55 60
Tyr Asn Gly Glu Ala Asn Asp Asp Glu Gly Ser Ser Glu Ala Thr Glu
65 70 75 80
Gly His Asp Glu Asp Asp Glu Ile Tyr Glu Gly Glu Tyr Gln Gly Ile
85 90 95
Pro Ser Met Asn Gln Ala Lys Asp Ser Ile Val Ser Val Gly Gln Pro
100 105 110
Lys Gly Asp Glu Tyr Lys Asp Arg Arg Glu Leu Glu Ser Glu Arg Arg
115 120 125
Ala Asp Glu Glu Glu Leu Ala Gln Gln Tyr Glu Leu Ile Ile Gln Glu
130 135 140
Cys Gly His Gly Arg Phe Gln Trp Ala Leu Phe Phe Val Leu Gly Met
145 150 155 160
Ala Leu Met Ala Asp Gly Val Glu Val Phe Val Val Gly Phe Val Leu
165 170 175
Pro Ser Ala Glu Thr Asp Leu Cys Ile Pro Asn Ser Gly Ser Gly Trp
180 185 190
Leu Gly Ser Ile Val Tyr Leu Gly Met Met Val Gly Ala Phe Phe Trp
195 200 205
Gly Gly Leu Ala Asp Lys Val Gly Arg Lys Gln Ser Leu Leu Ile Cys
210 215 220
Met Ser Val Asn Gly Phe Phe Ala Phe Leu Ser Ser Phe Val Gln Gly
225 230 235 240
Tyr Gly Phe Phe Leu Phe Cys Arg Leu Leu Ser Gly Phe Gly Ile Gly
245 250 255
Gly Ala Ile Pro Thr Val Phe Ser Tyr Phe Ala Glu Val Leu Ala Arg
260 265 270
Glu Lys Arg Gly Glu His Leu Ser Trp Leu Cys Met Phe Trp Met Ile
275 280 285
Gly Gly Ile Tyr Ala Ser Ala Met Ala Trp Ala Ile Ile Pro His Tyr
290 295 300
Gly Trp Ser Phe Ser Met Gly Ser Ala Tyr Gln Phe His Ser Trp Arg
305 310 315 320
Val Phe Val Ile Val Cys Ala Leu Pro Cys Val Ser Ser Val Val Ala
325 330 335
Leu Thr Phe Met Pro Glu Ser Pro Arg Phe Leu Leu Glu Val Gly Lys
340 345 350
His Asp Glu Ala Trp Met Ile Leu Lys Leu Ile His Asp Thr Asn Met
355 360 365
Arg Ala Arg Gly Gln Pro Glu Lys Val Phe Thr Val Asn Lys Ile Lys
370 375 380
Thr Pro Lys Gln Ile Asp Glu Leu Ile Glu Ile Glu Ser Asp Thr Gly
385 390 395 400
Thr Trp Tyr Arg Arg Cys Phe Val Arg Ile Arg Thr Glu Leu Tyr Gly
405 410 415
Ile Trp Leu Thr Phe Met Arg Cys Phe Asn Tyr Pro Val Arg Asp Asn
420 425 430
Thr Ile Lys Leu Thr Ile Val Trp Phe Thr Leu Ser Phe Gly Tyr Tyr
435 440 445
Gly Leu Ser Val Trp Phe Pro Asp Val Ile Lys Pro Leu Gln Ser Asp
450 455 460
Glu Tyr Ala Leu Leu Thr Arg Asn Val Glu Arg Asp Lys Tyr Ala Asn
465 470 475 480
Phe Thr Ile Asn Phe Thr Met Glu Asn Gln Ile His Thr Gly Met Glu
485 490 495
Tyr Asp Asn Gly Arg Phe Ile Gly Val Lys Phe Lys Ser Val Thr Phe
500 505 510
Lys Asp Ser Val Phe Lys Ser Cys Thr Phe Glu Asp Val Thr Ser Val
515 520 525
Asn Thr Tyr Phe Lys Asn Cys Thr Phe Ile Asp Thr Val Phe Asp Asn
530 535 540
Thr Asp Phe Glu Pro Tyr Lys Phe Ile Asp Ser Glu Phe Lys Asn Cys
545 550 555 560
Ser Phe Phe His Asn Lys Thr Gly Cys Gln Ile Thr Phe Asp Asp Asp
565 570 575
Tyr Ser Ala Tyr Trp Ile Tyr Phe Val Asn Phe Leu Gly Thr Leu Ala
580 585 590
Val Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp Arg Ile Gly
595 600 605
Arg Leu Thr Met Leu Gly Gly Ser Met Val Leu Ser Gly Ile Ser Cys
610 615 620
Phe Phe Leu Trp Phe Gly Thr Ser Glu Ser Met Met Ile Gly Met Leu
625 630 635 640
Cys Leu Tyr Asn Gly Leu Thr Ile Ser Ala Trp Asn Ser Leu Asp Val
645 650 655
Val Thr Val Glu Leu Tyr Pro Thr Asp Arg Arg Ala Thr Gly Phe Gly
660 665 670
Phe Leu Asn Ala Leu Cys Lys Ala Ala Ala Val Leu Gly Asn Leu Ile
675 680 685
Phe Gly Ser Leu Val Ser Ile Thr Lys Ser Ile Pro Ile Leu Leu Ala
690 695 700
Ser Thr Val Leu Val Cys Gly Gly Leu Val Gly Leu Cys Leu Pro Asp
705 710 715 720
Thr Arg Thr Gln Val Leu Met Ala Glu Asp Ala Asp Met Arg Asn Glu
725 730 735
Leu Glu Glu Met Gln Arg Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu
740 745 750
Glu Ser Thr Arg Arg Met Leu Gln Leu Val Glu Glu Ser Lys Asp Ala
755 760 765
Gly Ile Arg Thr Leu Val Met Leu Asp Glu Gln Gly Glu Gln Leu Glu
770 775 780
Arg Ile Glu Glu Gly Met Asp Gln Ile Asn Lys Asp Met Lys Glu Ala
785 790 795 800
Glu Lys Asn Leu Thr Asp Leu Gly Lys Phe Cys Gly Leu Cys Val Cys
805 810 815
Pro Cys Asn Lys Leu Lys Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly
820 825 830
Asn Asn Gln Asp Gly Val Val Ala Ser Gln Pro Ala Arg Val Val Asp
835 840 845
Glu Arg Glu Gln Met Ala Ile Ser Gly Gly Phe Ile Arg Arg Val Thr
850 855 860
Asn Asp Ala Arg Glu Asn Glu Met Asp Glu Asn Leu Glu Gln Val Ser
865 870 875 880
Gly Ile Ile Gly Asn Leu Arg His Met Ala Leu Asp Met Gly Asn Glu
885 890 895
Ile Asp Thr Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp
900 905 910
Ser Asn Lys Thr Arg Ile Asp Glu Ala Asn Gln Arg Ala Thr Lys Met
915 920 925
Leu Gly Ser Gly Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala
930 935 940
Leu Glu Leu Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys
945 950 955 960
Leu Ala Gln Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val
965 970 975
Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp
980 985 990
Arg His His Thr His Ser Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp
995 1000 1005
Phe Leu Arg Asn Asn Ala Lys Ser Tyr Arg Cys Ala Leu Leu Ser
1010 1015 1020
His Arg Asp Gly Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu
1025 1030 1035
Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln
1040 1045 1050
Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val
1055 1060 1065
Gly His Phe Thr Leu Gly Cys Val Leu Glu Glu Gln Glu His Gln
1070 1075 1080
Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser Met Pro
1085 1090 1095
Pro Leu Leu Lys Gln Ala Ile Glu Leu Phe Asp Arg Gln Gly Ala
1100 1105 1110
Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu
1115 1120 1125
Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Thr Asp Ala Leu
1130 1135 1140
Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp
1145 1150 1155
Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp
1160 1165 1170
Leu Asp Met Leu Pro Gly
1175
<210> 5
<211> 1725
<212> DNA
<213> artificial
<220>
<223> Cholinetransporter-SNAP25-tTA (1)(pCMV-Tet3G)
<400> 5
gaattcacca tggctttcca tgtggaagga ctgatagcta tcatcgtgtt ctaccttcta 60
attttgctgg ttggaatatg ggctgcctgg agaaccaaaa acagtggcag cgcagaagag 120
cgcagcgaag ccatcatagt tggtggccga gatattggtt tattggttgg tggatttacc 180
atgacagcta cctgggtcgg aggagggtat atcaatggca cagctgaagc agtttatgta 240
ccaggttatg gcctagcttg ggctcaggca ccaattggat attctcttag tctgatttta 300
ggtggcctgt tctttgcaaa acctatgcgt tcaaaggggt atgtgaccat gttagacccg 360
tttcagcaaa tctatggaaa acgcatgggc ggactcctgt ttattcctgc actgatggga 420
gaaatgttct gggctgcagc aattttctct gctttgggag ccaccatcag cgtgatcatc 480
gatgtggata tgcacatttc tgtcatcatc tctgcactca ttgccactct gtacacactg 540
gtgggagggc tctattctgt ggcctacact gatgtcgttc agctcttttg catttttgta 600
gggctgtgga tcagcgtccc ctttgcattg tcacatcctg cagtcgcaga catcgggttc 660
actgctgtgc atgccaaata ccaaaagccg tggctgggaa ctgttgactc atctgaagtc 720
tactcttggc ttgatagttt tctgttgttg atgctgggtg gaatcccatg gcaagcatac 780
tttcagaggg ttctctcttc ttcctcagcc acctatgctc aagtgctgtc cttcctggca 840
gctttcgggt gcctggtgat ggccatccca gccatactca ttggggccat tggagcatca 900
acagactgga accagactgc atatgggctt ccagatccca agactacaga agaggcagac 960
atgattttac caattgttct gcagtatctc tgccctgtgt atatttcttt ctttggtctt 1020
ggtgcagttt ctgctgctgt tatgtcatca gcagattctt ccatcttgtc agcaagttcc 1080
atgtttgcac ggaacatcta ccagctttcc ttcagacaaa atgcttcgga caaagaaatc 1140
gtttgggtta tgcgaatcac agtgtttgtg tttggagcat ctgcaacagc catggccttg 1200
ctgacgaaaa ctgtgtatgg gctctggtac ctcagttctg accttgttta catcgttatc 1260
ttcccccagc tgctttgtgt actctttgtt aagggaacca acacctatgg ggccgtggca 1320
ggttatgttt ctggcctctt cctgagaata actggagggg agccatatct gtatcttaac 1380
aagcttaaat caagtgatgc ttacaaaaaa gcctggggca ataatcagga cggagtggtg 1440
gccagccagc ctgctcgtgt agtggacgaa cgggagcaga tggccatcag tggcggcttc 1500
atccgcaggg taacaaatga tgcccgagaa aatgaaatgg atgaaaacct agagcaggtg 1560
agcggcatca tcgggaacct ccgtcacatg gccctggata tgggcaatga gatcgataca 1620
cagaatcgcc agatcgacag gatcatggag aaggctgatt ccaacaaaac cagaattgat 1680
gaggccaacc aacgtgcaac aaagatgctg ggaagtggtt ctaga 1725
<210> 6
<211> 817
<212> PRT
<213> artificial
<220>
<223> Cholinetransporter-SNAP25-tTA (1)(pCMV-Tet3G)
<400> 6
Met Ala Phe His Val Glu Gly Leu Ile Ala Ile Ile Val Phe Tyr Leu
1 5 10 15
Leu Ile Leu Leu Val Gly Ile Trp Ala Ala Trp Arg Thr Lys Asn Ser
20 25 30
Gly Ser Ala Glu Glu Arg Ser Glu Ala Ile Ile Val Gly Gly Arg Asp
35 40 45
Ile Gly Leu Leu Val Gly Gly Phe Thr Met Thr Ala Thr Trp Val Gly
50 55 60
Gly Gly Tyr Ile Asn Gly Thr Ala Glu Ala Val Tyr Val Pro Gly Tyr
65 70 75 80
Gly Leu Ala Trp Ala Gln Ala Pro Ile Gly Tyr Ser Leu Ser Leu Ile
85 90 95
Leu Gly Gly Leu Phe Phe Ala Lys Pro Met Arg Ser Lys Gly Tyr Val
100 105 110
Thr Met Leu Asp Pro Phe Gln Gln Ile Tyr Gly Lys Arg Met Gly Gly
115 120 125
Leu Leu Phe Ile Pro Ala Leu Met Gly Glu Met Phe Trp Ala Ala Ala
130 135 140
Ile Phe Ser Ala Leu Gly Ala Thr Ile Ser Val Ile Ile Asp Val Asp
145 150 155 160
Met His Ile Ser Val Ile Ile Ser Ala Leu Ile Ala Thr Leu Tyr Thr
165 170 175
Leu Val Gly Gly Leu Tyr Ser Val Ala Tyr Thr Asp Val Val Gln Leu
180 185 190
Phe Cys Ile Phe Val Gly Leu Trp Ile Ser Val Pro Phe Ala Leu Ser
195 200 205
His Pro Ala Val Ala Asp Ile Gly Phe Thr Ala Val His Ala Lys Tyr
210 215 220
Gln Lys Pro Trp Leu Gly Thr Val Asp Ser Ser Glu Val Tyr Ser Trp
225 230 235 240
Leu Asp Ser Phe Leu Leu Leu Met Leu Gly Gly Ile Pro Trp Gln Ala
245 250 255
Tyr Phe Gln Arg Val Leu Ser Ser Ser Ser Ala Thr Tyr Ala Gln Val
260 265 270
Leu Ser Phe Leu Ala Ala Phe Gly Cys Leu Val Met Ala Ile Pro Ala
275 280 285
Ile Leu Ile Gly Ala Ile Gly Ala Ser Thr Asp Trp Asn Gln Thr Ala
290 295 300
Tyr Gly Leu Pro Asp Pro Lys Thr Thr Glu Glu Ala Asp Met Ile Leu
305 310 315 320
Pro Ile Val Leu Gln Tyr Leu Cys Pro Val Tyr Ile Ser Phe Phe Gly
325 330 335
Leu Gly Ala Val Ser Ala Ala Val Met Ser Ser Ala Asp Ser Ser Ile
340 345 350
Leu Ser Ala Ser Ser Met Phe Ala Arg Asn Ile Tyr Gln Leu Ser Phe
355 360 365
Arg Gln Asn Ala Ser Asp Lys Glu Ile Val Trp Val Met Arg Ile Thr
370 375 380
Val Phe Val Phe Gly Ala Ser Ala Thr Ala Met Ala Leu Leu Thr Lys
385 390 395 400
Thr Val Tyr Gly Leu Trp Tyr Leu Ser Ser Asp Leu Val Tyr Ile Val
405 410 415
Ile Phe Pro Gln Leu Leu Cys Val Leu Phe Val Lys Gly Thr Asn Thr
420 425 430
Tyr Gly Ala Val Ala Gly Tyr Val Ser Gly Leu Phe Leu Arg Ile Thr
435 440 445
Gly Gly Glu Pro Tyr Leu Tyr Leu Asn Lys Leu Lys Ser Ser Asp Ala
450 455 460
Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val Val Ala Ser Gln
465 470 475 480
Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala Ile Ser Gly Gly
485 490 495
Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn Glu Met Asp Glu
500 505 510
Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu Arg His Met Ala
515 520 525
Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile Asp Arg
530 535 540
Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile Asp Glu Ala Asn
545 550 555 560
Gln Arg Ala Thr Lys Met Leu Gly Ser Gly Ser Arg Leu Asp Lys Ser
565 570 575
Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Gly Val Gly Ile Glu
580 585 590
Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu Gln Pro
595 600 605
Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu
610 615 620
Pro Ile Glu Met Leu Asp Arg His His Thr His Ser Cys Pro Leu Glu
625 630 635 640
Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser Tyr Arg
645 650 655
Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His Leu Gly Thr
660 665 670
Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe
675 680 685
Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser
690 695 700
Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Glu Gln Glu His
705 710 715 720
Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser Met Pro
725 730 735
Pro Leu Leu Lys Gln Ala Ile Glu Leu Phe Asp Arg Gln Gly Ala Glu
740 745 750
Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys
755 760 765
Gln Leu Lys Cys Glu Ser Gly Gly Pro Thr Asp Ala Leu Asp Asp Phe
770 775 780
Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp
785 790 795 800
Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro
805 810 815
Gly
<210> 7
<211> 2370
<212> DNA
<213> artificial
<220>
<223> Cholinetransporter-SNAP25-tTA (3)(pCMV-Tet3G)
<400> 7
gaattcacca tggctttcca tgtggaagga ctgatagcta tcatcgtgtt ctaccttcta 60
attttgctgg ttggaatatg ggctgcctgg agaaccaaaa acagtggcag cgcagaagag 120
cgcagcgaag ccatcatagt tggtggccga gatattggtt tattggttgg tggatttacc 180
atgacagcta cctgggtcgg aggagggtat atcaatggca cagctgaagc agtttatgta 240
ccaggttatg gcctagcttg ggctcaggca ccaattggat attctcttag tctgatttta 300
ggtggcctgt tctttgcaaa acctatgcgt tcaaaggggt atgtgaccat gttagacccg 360
tttcagcaaa tctatggaaa acgcatgggc ggactcctgt ttattcctgc actgatggga 420
gaaatgttct gggctgcagc aattttctct gctttgggag ccaccatcag cgtgatcatc 480
gatgtggata tgcacatttc tgtcatcatc tctgcactca ttgccactct gtacacactg 540
gtgggagggc tctattctgt ggcctacact gatgtcgttc agctcttttg catttttgta 600
gggctgtgga tcagcgtccc ctttgcattg tcacatcctg cagtcgcaga catcgggttc 660
actgctgtgc atgccaaata ccaaaagccg tggctgggaa ctgttgactc atctgaagtc 720
tactcttggc ttgatagttt tctgttgttg atgctgggtg gaatcccatg gcaagcatac 780
tttcagaggg ttctctcttc ttcctcagcc acctatgctc aagtgctgtc cttcctggca 840
gctttcgggt gcctggtgat ggccatccca gccatactca ttggggccat tggagcatca 900
acagactgga accagactgc atatgggctt ccagatccca agactacaga agaggcagac 960
atgattttac caattgttct gcagtatctc tgccctgtgt atatttcttt ctttggtctt 1020
ggtgcagttt ctgctgctgt tatgtcatca gcagattctt ccatcttgtc agcaagttcc 1080
atgtttgcac ggaacatcta ccagctttcc ttcagacaaa atgcttcgga caaagaaatc 1140
gtttgggtta tgcgaatcac agtgtttgtg tttggagcat ctgcaacagc catggccttg 1200
ctgacgaaaa ctgtgtatgg gctctggtac ctcagttctg accttgttta catcgttatc 1260
ttcccccagc tgctttgtgt actctttgtt aagggaacca acacctatgg ggccgtggca 1320
ggttatgttt ctggcctctt cctgagaata actggagggg agccatatct gtatcttcag 1380
cccttgatct tctaccctgg ctattaccct gatgataatg gtatatataa tcagaaattt 1440
ccatttaaaa cacttgccat ggttacatca ttcttaacca acatttgcat ctcctatcta 1500
gccaagtatc tatttgaaag tggaaccttg ccacctaaat tagatgtatt tgatgctgtt 1560
gttgcaagac acagtgaaga aaacatggat aagacaattc ttgtcaaaaa tgaaaatatt 1620
aaattagatg aacttgcact tgtgaagcca cgacagagca tgaccctcag ctcaactttc 1680
accaataaag aggccttcct tgatgttgat tccagtccag aagggtctgg gactgaagat 1740
aatttacagg ccgaagacgc agacatgcgc aatgagctgg aggagatgca gcgaagggct 1800
gaccagttgg ctgatgagtc gctggaaagc acccgtcgta tgctgcaact ggttgaagag 1860
agtaaagatg ctggtatcag gactttggtt atgttggatg aacaaggaga acaactggaa 1920
cgcattgagg aagggatgga ccaaatcaat aaggacatga aagaagcaga aaagaatttg 1980
acggacctag gaaaattctg cgggctttgt gtgtgtccct gtaacaagct taaatcaagt 2040
gatgcttaca aaaaagcctg gggcaataat caggacggag tggtggccag ccagcctgct 2100
cgtgtagtgg acgaacggga gcagatggcc atcagtggcg gcttcatccg cagggtaaca 2160
aatgatgccc gagaaaatga aatggatgaa aacctagagc aggtgagcgg catcatcggg 2220
aacctccgtc acatggccct ggatatgggc aatgagatcg atacacagaa tcgccagatc 2280
gacaggatca tggagaaggc tgattccaac aaaaccagaa ttgatgaggc caaccaacgt 2340
gcaacaaaga tgctgggaag tggttctaga 2370
<210> 8
<211> 1032
<212> PRT
<213> artificial
<220>
<223> Cholinetransporter-SNAP25-tTA (3)(pCMV-Tet3G)
<400> 8
Met Ala Phe His Val Glu Gly Leu Ile Ala Ile Ile Val Phe Tyr Leu
1 5 10 15
Leu Ile Leu Leu Val Gly Ile Trp Ala Ala Trp Arg Thr Lys Asn Ser
20 25 30
Gly Ser Ala Glu Glu Arg Ser Glu Ala Ile Ile Val Gly Gly Arg Asp
35 40 45
Ile Gly Leu Leu Val Gly Gly Phe Thr Met Thr Ala Thr Trp Val Gly
50 55 60
Gly Gly Tyr Ile Asn Gly Thr Ala Glu Ala Val Tyr Val Pro Gly Tyr
65 70 75 80
Gly Leu Ala Trp Ala Gln Ala Pro Ile Gly Tyr Ser Leu Ser Leu Ile
85 90 95
Leu Gly Gly Leu Phe Phe Ala Lys Pro Met Arg Ser Lys Gly Tyr Val
100 105 110
Thr Met Leu Asp Pro Phe Gln Gln Ile Tyr Gly Lys Arg Met Gly Gly
115 120 125
Leu Leu Phe Ile Pro Ala Leu Met Gly Glu Met Phe Trp Ala Ala Ala
130 135 140
Ile Phe Ser Ala Leu Gly Ala Thr Ile Ser Val Ile Ile Asp Val Asp
145 150 155 160
Met His Ile Ser Val Ile Ile Ser Ala Leu Ile Ala Thr Leu Tyr Thr
165 170 175
Leu Val Gly Gly Leu Tyr Ser Val Ala Tyr Thr Asp Val Val Gln Leu
180 185 190
Phe Cys Ile Phe Val Gly Leu Trp Ile Ser Val Pro Phe Ala Leu Ser
195 200 205
His Pro Ala Val Ala Asp Ile Gly Phe Thr Ala Val His Ala Lys Tyr
210 215 220
Gln Lys Pro Trp Leu Gly Thr Val Asp Ser Ser Glu Val Tyr Ser Trp
225 230 235 240
Leu Asp Ser Phe Leu Leu Leu Met Leu Gly Gly Ile Pro Trp Gln Ala
245 250 255
Tyr Phe Gln Arg Val Leu Ser Ser Ser Ser Ala Thr Tyr Ala Gln Val
260 265 270
Leu Ser Phe Leu Ala Ala Phe Gly Cys Leu Val Met Ala Ile Pro Ala
275 280 285
Ile Leu Ile Gly Ala Ile Gly Ala Ser Thr Asp Trp Asn Gln Thr Ala
290 295 300
Tyr Gly Leu Pro Asp Pro Lys Thr Thr Glu Glu Ala Asp Met Ile Leu
305 310 315 320
Pro Ile Val Leu Gln Tyr Leu Cys Pro Val Tyr Ile Ser Phe Phe Gly
325 330 335
Leu Gly Ala Val Ser Ala Ala Val Met Ser Ser Ala Asp Ser Ser Ile
340 345 350
Leu Ser Ala Ser Ser Met Phe Ala Arg Asn Ile Tyr Gln Leu Ser Phe
355 360 365
Arg Gln Asn Ala Ser Asp Lys Glu Ile Val Trp Val Met Arg Ile Thr
370 375 380
Val Phe Val Phe Gly Ala Ser Ala Thr Ala Met Ala Leu Leu Thr Lys
385 390 395 400
Thr Val Tyr Gly Leu Trp Tyr Leu Ser Ser Asp Leu Val Tyr Ile Val
405 410 415
Ile Phe Pro Gln Leu Leu Cys Val Leu Phe Val Lys Gly Thr Asn Thr
420 425 430
Tyr Gly Ala Val Ala Gly Tyr Val Ser Gly Leu Phe Leu Arg Ile Thr
435 440 445
Gly Gly Glu Pro Tyr Leu Tyr Leu Gln Pro Leu Ile Phe Tyr Pro Gly
450 455 460
Tyr Tyr Pro Asp Asp Asn Gly Ile Tyr Asn Gln Lys Phe Pro Phe Lys
465 470 475 480
Thr Leu Ala Met Val Thr Ser Phe Leu Thr Asn Ile Cys Ile Ser Tyr
485 490 495
Leu Ala Lys Tyr Leu Phe Glu Ser Gly Thr Leu Pro Pro Lys Leu Asp
500 505 510
Val Phe Asp Ala Val Val Ala Arg His Ser Glu Glu Asn Met Asp Lys
515 520 525
Thr Ile Leu Val Lys Asn Glu Asn Ile Lys Leu Asp Glu Leu Ala Leu
530 535 540
Val Lys Pro Arg Gln Ser Met Thr Leu Ser Ser Thr Phe Thr Asn Lys
545 550 555 560
Glu Ala Phe Leu Asp Val Asp Ser Ser Pro Glu Gly Ser Gly Thr Glu
565 570 575
Asp Asn Leu Gln Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu
580 585 590
Met Gln Arg Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr
595 600 605
Arg Arg Met Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg
610 615 620
Thr Leu Val Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu
625 630 635 640
Glu Gly Met Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn
645 650 655
Leu Thr Asp Leu Gly Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn
660 665 670
Lys Leu Lys Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln
675 680 685
Asp Gly Val Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu
690 695 700
Gln Met Ala Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala
705 710 715 720
Arg Glu Asn Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile
725 730 735
Gly Asn Leu Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr
740 745 750
Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys
755 760 765
Thr Arg Ile Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser
770 775 780
Gly Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu
785 790 795 800
Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln
805 810 815
Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys
820 825 830
Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His
835 840 845
Thr His Ser Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg
850 855 860
Asn Asn Ala Lys Ser Tyr Arg Cys Ala Leu Leu Ser His Arg Asp Gly
865 870 875 880
Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr
885 890 895
Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu
900 905 910
Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys
915 920 925
Val Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr
930 935 940
Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Lys Gln Ala Ile Glu Leu
945 950 955 960
Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu
965 970 975
Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro
980 985 990
Thr Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala
995 1000 1005
Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp
1010 1015 1020
Asp Phe Asp Leu Asp Met Leu Pro Gly
1025 1030
<210> 9
<211> 603
<212> DNA
<213> artificial
<220>
<223> Synaptotagmin-SNAP25-tTA(pCMV-Tet3G)
<400> 9
gaattcacca tgaggaacat tttcaagagg aaccaggagc ctattgtggc tcctgccacc 60
accaccgcca cgatgcccat tggacccgtg gacaactcca ctgagagtgg gggtgctggg 120
gagagccagg aggacatgtt tgccaaactg aaggagaagt tattcaatga gataaacaag 180
attcccttac caccctgggc actgatcgcc attgctgtgg ttgctgggct cctgcttctc 240
acctgctgct tctgcatcaa gcttaaatca agtgatgctt acaaaaaagc ctggggcaat 300
aatcaggacg gagtggtggc cagccagcct gctcgtgtag tggacgaacg ggagcagatg 360
gccatcagtg gcggcttcat ccgcagggta acaaatgatg cccgagaaaa tgaaatggat 420
gaaaacctag agcaggtgag cggcatcatc gggaacctcc gtcacatggc cctggatatg 480
ggcaatgaga tcgatacaca gaatcgccag atcgacagga tcatggagaa ggctgattcc 540
aacaaaacca gaattgatga ggccaaccaa cgtgcaacaa agatgctggg aagtggttct 600
aga 603
<210> 10
<211> 443
<212> PRT
<213> artificial
<220>
<223> Synaptotagmin-SNAP25-tTA(pCMV-Tet3G)
<400> 10
Met Arg Asn Ile Phe Lys Arg Asn Gln Glu Pro Ile Val Ala Pro Ala
1 5 10 15
Thr Thr Thr Ala Thr Met Pro Ile Gly Pro Val Asp Asn Ser Thr Glu
20 25 30
Ser Gly Gly Ala Gly Glu Ser Gln Glu Asp Met Phe Ala Lys Leu Lys
35 40 45
Glu Lys Leu Phe Asn Glu Ile Asn Lys Ile Pro Leu Pro Pro Trp Ala
50 55 60
Leu Ile Ala Ile Ala Val Val Ala Gly Leu Leu Leu Leu Thr Cys Cys
65 70 75 80
Phe Cys Ile Lys Leu Lys Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly
85 90 95
Asn Asn Gln Asp Gly Val Val Ala Ser Gln Pro Ala Arg Val Val Asp
100 105 110
Glu Arg Glu Gln Met Ala Ile Ser Gly Gly Phe Ile Arg Arg Val Thr
115 120 125
Asn Asp Ala Arg Glu Asn Glu Met Asp Glu Asn Leu Glu Gln Val Ser
130 135 140
Gly Ile Ile Gly Asn Leu Arg His Met Ala Leu Asp Met Gly Asn Glu
145 150 155 160
Ile Asp Thr Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp
165 170 175
Ser Asn Lys Thr Arg Ile Asp Glu Ala Asn Gln Arg Ala Thr Lys Met
180 185 190
Leu Gly Ser Gly Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala
195 200 205
Leu Glu Leu Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys
210 215 220
Leu Ala Gln Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val
225 230 235 240
Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp
245 250 255
Arg His His Thr His Ser Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp
260 265 270
Phe Leu Arg Asn Asn Ala Lys Ser Tyr Arg Cys Ala Leu Leu Ser His
275 280 285
Arg Asp Gly Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln
290 295 300
Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe
305 310 315 320
Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr
325 330 335
Leu Gly Cys Val Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu
340 345 350
Arg Glu Thr Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Lys Gln Ala
355 360 365
Ile Glu Leu Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly
370 375 380
Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser
385 390 395 400
Gly Gly Pro Thr Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro
405 410 415
Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala
420 425 430
Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly
435 440
<210> 11
<211> 3600
<212> DNA
<213> artificial
<220>
<223> mAN02-SNAP25(pcDNA3.1)
<400> 11
cttaagatgc ccgccctgcg ccccgctctg ctgtgggcgc tgctggcgct ctggctgtgc 60
tgcgcggccc ccgcgcatgc attgcagtgt cgagatcctg ccacctgtct gagccagtat 120
tgtgccgaca aagctcggga tggcgtctgt gatgaggcct gcaacagcca tgcctgccag 180
tgggatgggg gtgactgttc tctcaccatg gagaacccct gggccaactg ctcctcccca 240
cttccctgct gggattatat caacaaccag tgtgatgagc tgtgcaacac ggtcgagtgc 300
ctgtttgaca actttgaatg ccaggggaac agcaagacat gcaagtatga caaatactgt 360
gcagaccact tcaaagacaa ccactgtgac caggggtgca acagtgagga gtgtggttgg 420
gatgggctgg actgtgctgc tgaccaacct gagaacctgg cagaaggtac cctggttatt 480
gtggtattga tgccacctga acaactgctc caggatgctc gcagcttctt gcgggcactg 540
ggtaccctgc tccacaccaa cctgcgcatt aagcgggact cccaggggga actcatggtg 600
tacccctatt atggtgagaa gtcagctgct atgaagaaac agaggatgac acgcagatcc 660
cttcctggtg aacaagaaca ggaggtggct ggctctaaag tctttctgga aattgacaac 720
cgccagtgtg ttcaagactc agaccactgc ttcaagaaca cggatgcagc agcagctctc 780
ctggcctctc acgccataca ggggaccctg tcataccctc ttgtgtctgt cgtcagtgaa 840
tccctgactc cagaacgcac tcagctcctc tatctccttg ctgttgctgt tgtcatcatt 900
ctgtttatta ttctgctggg ggtaatcaac aagcttaaat caagtgatgc ttacaaaaaa 960
gcctggggca ataatcagga cggagtggtg gccagccagc ctgctcgtgt agtggacgaa 1020
cgggagcaga tggccatcag tggcggcttc atccgcaggg taacaaatga tgcccgagaa 1080
aatgaaatgg atgaaaacct agagcaggtg agcggcatca tcgggaacct ccgtcacatg 1140
gccctggata tgggcaatga gatcgataca cagaatcgcc agatcgacag gatcatggag 1200
aaggctgatt ccaacaaaac cagaattgat gaggccaacc aacgtgcaac aaagatgctg 1260
ggaagtggta tggcaaaacg aaagcgtaag catggctctc tctggctgcc tgaaggtttc 1320
actcttcgcc gagatgcaag caatcacaag cgtcgtgagc cagtgggaca ggatgctgtg 1380
gggctgaaaa atctctcagt gcaagtctca gaagctaacc taattggtac tggaacaagt 1440
gaacactggg tcgatgatga agggccccag ccaaagaaag taaaggctga agatgaggcc 1500
ttactctcag aagaagatga ccccattgat cgacggccat ggacacagca gcaccttgaa 1560
gctgcagaca tccgtaggac accatcgctg gctctcaccc ctcctcaggc agagcaggag 1620
gtggatgtgt tagatgtgaa tgtccgtggc ccagatggct gcaccccatt gatgttggct 1680
tctctccgag gaggcagctc agatttgagt gatgaagatg aagatgcaga ggactcttct 1740
gctaacatca tcacagactt ggtctaccag ggtgccagcc tccaggccca gacagaccgg 1800
actggtgaga tggccctgca ccttgcagcc cgctactcac gggctgatgc tgccaagcgt 1860
ctcctggatg caggtgcaga tgccaatgcc caggacaaca tgggccgctg tccactccat 1920
gctgcagtgg cagctgatgc ccaaggtgtc ttccagattc tgattcgcaa ccgagtaact 1980
gatctagatg ccaggatgaa tgatggtact acacccctga tcctggctgc ccgcctggct 2040
gtggagggaa tggtggcaga actgatcaac tgccaagcgg atgtgaatgc agtggatgac 2100
catggaaaat ctgctcttca ctgggcagct gctgtcaata atgtggaggc aactcttttg 2160
ttgttgaaaa atggggccaa ccgagacatg caggacaaca aggaagagac acctctgttt 2220
cttgctgccc gggaggggag ctatgaagca gccaagatcc tgttagacca ttttgccaat 2280
cgagacatca cagaccatat ggatcgtctt ccccgggatg tggctcggga tcgcatgcac 2340
catgacattg tgcgccttct ggatgaatac aatgtgaccc caagccctcc aggcaccgtg 2400
ttgacttctg ctctctcacc tgtcatctgt gggcccaaca gatctttcct cagcctgaag 2460
cacaccccaa tgggcaagaa gtctagacgg cccagtgcca agagtaccat gcctactagc 2520
ctccctaacc ttgccaagga ggcaaaggat gccaagggta gtaggaggaa gaagtctctg 2580
agtgagaagg tccaactgtc tgagagttca gtaactttat cccctgttga ttccctagaa 2640
tctcctcaca cgtatgtttc cgacaccaca tcctctccaa tgattacatc ccctgggatc 2700
ttacaggcct cacccaaccc tatgttggcc actgccgccc ctcctgcccc agtccatgcc 2760
cagcatgcac tatctttttc taaccttcat gaaatgcagc ctttggcaca tggggccagc 2820
actgtgcttc cctcagtgag ccagttgcta tcccaccacc acattgtgtc tccaggcagt 2880
ggcagtgctg gaagcttgag taggctccat ccagtcccag tcccagcaga ttggatgaac 2940
cgcatggagg tgaatgagac ccagtacaat gagatgtttg gtatggtcct ggctccagct 3000
gagggcaccc atcctggcat agctccccag agcaggccac ctgaagggaa gcacataacc 3060
acccctcggg agcccttgcc ccccattgtg actttccagc tcatccctaa aggcagtatt 3120
gcccaaccag cgggggctcc ccagcctcag tccacctgcc ctccagctgt tgcgggcccc 3180
ctgcccacca tgtaccagat tccagaaatg gcccgtttgc ccagtgtggc tttccccact 3240
gccatgatgc cccagcagga cgggcaggta gctcagacca ttctcccagc ctatcatcct 3300
ttcccagcct ctgtgggcaa gtaccccaca cccccttcac agcacagtta tgcttcctca 3360
aatgctgctg agcgaacacc cagtcacagt ggtcacctcc agggtgagca tccctacctg 3420
acaccatccc cagagtctcc tgaccagtgg tcaagttcat caccccactc tgcttctgac 3480
tggtcagatg tgaccaccag ccctacccct gggggtgctg gaggaggtca gcggggacct 3540
gggacacaca tgtctgagcc accacacaac aacatgcagg tttatgcgtg ataatctaga 3600
<210> 12
<211> 1194
<212> PRT
<213> artificial
<220>
<223> mAN02-SNAP25(pcDNA3.1)
<400> 12
Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp
1 5 10 15
Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Pro Ala
20 25 30
Thr Cys Leu Ser Gln Tyr Cys Ala Asp Lys Ala Arg Asp Gly Val Cys
35 40 45
Asp Glu Ala Cys Asn Ser His Ala Cys Gln Trp Asp Gly Gly Asp Cys
50 55 60
Ser Leu Thr Met Glu Asn Pro Trp Ala Asn Cys Ser Ser Pro Leu Pro
65 70 75 80
Cys Trp Asp Tyr Ile Asn Asn Gln Cys Asp Glu Leu Cys Asn Thr Val
85 90 95
Glu Cys Leu Phe Asp Asn Phe Glu Cys Gln Gly Asn Ser Lys Thr Cys
100 105 110
Lys Tyr Asp Lys Tyr Cys Ala Asp His Phe Lys Asp Asn His Cys Asp
115 120 125
Gln Gly Cys Asn Ser Glu Glu Cys Gly Trp Asp Gly Leu Asp Cys Ala
130 135 140
Ala Asp Gln Pro Glu Asn Leu Ala Glu Gly Thr Leu Val Ile Val Val
145 150 155 160
Leu Met Pro Pro Glu Gln Leu Leu Gln Asp Ala Arg Ser Phe Leu Arg
165 170 175
Ala Leu Gly Thr Leu Leu His Thr Asn Leu Arg Ile Lys Arg Asp Ser
180 185 190
Gln Gly Glu Leu Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala
195 200 205
Met Lys Lys Gln Arg Met Thr Arg Arg Ser Leu Pro Gly Glu Gln Glu
210 215 220
Gln Glu Val Ala Gly Ser Lys Val Phe Leu Glu Ile Asp Asn Arg Gln
225 230 235 240
Cys Val Gln Asp Ser Asp His Cys Phe Lys Asn Thr Asp Ala Ala Ala
245 250 255
Ala Leu Leu Ala Ser His Ala Ile Gln Gly Thr Leu Ser Tyr Pro Leu
260 265 270
Val Ser Val Val Ser Glu Ser Leu Thr Pro Glu Arg Thr Gln Leu Leu
275 280 285
Tyr Leu Leu Ala Val Ala Val Val Ile Ile Leu Phe Ile Ile Leu Leu
290 295 300
Gly Val Ile Asn Lys Leu Lys Ser Ser Asp Ala Tyr Lys Lys Ala Trp
305 310 315 320
Gly Asn Asn Gln Asp Gly Val Val Ala Ser Gln Pro Ala Arg Val Val
325 330 335
Asp Glu Arg Glu Gln Met Ala Ile Ser Gly Gly Phe Ile Arg Arg Val
340 345 350
Thr Asn Asp Ala Arg Glu Asn Glu Met Asp Glu Asn Leu Glu Gln Val
355 360 365
Ser Gly Ile Ile Gly Asn Leu Arg His Met Ala Leu Asp Met Gly Asn
370 375 380
Glu Ile Asp Thr Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala
385 390 395 400
Asp Ser Asn Lys Thr Arg Ile Asp Glu Ala Asn Gln Arg Ala Thr Lys
405 410 415
Met Leu Gly Ser Gly Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu
420 425 430
Trp Leu Pro Glu Gly Phe Thr Leu Arg Arg Asp Ala Ser Asn His Lys
435 440 445
Arg Arg Glu Pro Val Gly Gln Asp Ala Val Gly Leu Lys Asn Leu Ser
450 455 460
Val Gln Val Ser Glu Ala Asn Leu Ile Gly Thr Gly Thr Ser Glu His
465 470 475 480
Trp Val Asp Asp Glu Gly Pro Gln Pro Lys Lys Val Lys Ala Glu Asp
485 490 495
Glu Ala Leu Leu Ser Glu Glu Asp Asp Pro Ile Asp Arg Arg Pro Trp
500 505 510
Thr Gln Gln His Leu Glu Ala Ala Asp Ile Arg Arg Thr Pro Ser Leu
515 520 525
Ala Leu Thr Pro Pro Gln Ala Glu Gln Glu Val Asp Val Leu Asp Val
530 535 540
Asn Val Arg Gly Pro Asp Gly Cys Thr Pro Leu Met Leu Ala Ser Leu
545 550 555 560
Arg Gly Gly Ser Ser Asp Leu Ser Asp Glu Asp Glu Asp Ala Glu Asp
565 570 575
Ser Ser Ala Asn Ile Ile Thr Asp Leu Val Tyr Gln Gly Ala Ser Leu
580 585 590
Gln Ala Gln Thr Asp Arg Thr Gly Glu Met Ala Leu His Leu Ala Ala
595 600 605
Arg Tyr Ser Arg Ala Asp Ala Ala Lys Arg Leu Leu Asp Ala Gly Ala
610 615 620
Asp Ala Asn Ala Gln Asp Asn Met Gly Arg Cys Pro Leu His Ala Ala
625 630 635 640
Val Ala Ala Asp Ala Gln Gly Val Phe Gln Ile Leu Ile Arg Asn Arg
645 650 655
Val Thr Asp Leu Asp Ala Arg Met Asn Asp Gly Thr Thr Pro Leu Ile
660 665 670
Leu Ala Ala Arg Leu Ala Val Glu Gly Met Val Ala Glu Leu Ile Asn
675 680 685
Cys Gln Ala Asp Val Asn Ala Val Asp Asp His Gly Lys Ser Ala Leu
690 695 700
His Trp Ala Ala Ala Val Asn Asn Val Glu Ala Thr Leu Leu Leu Leu
705 710 715 720
Lys Asn Gly Ala Asn Arg Asp Met Gln Asp Asn Lys Glu Glu Thr Pro
725 730 735
Leu Phe Leu Ala Ala Arg Glu Gly Ser Tyr Glu Ala Ala Lys Ile Leu
740 745 750
Leu Asp His Phe Ala Asn Arg Asp Ile Thr Asp His Met Asp Arg Leu
755 760 765
Pro Arg Asp Val Ala Arg Asp Arg Met His His Asp Ile Val Arg Leu
770 775 780
Leu Asp Glu Tyr Asn Val Thr Pro Ser Pro Pro Gly Thr Val Leu Thr
785 790 795 800
Ser Ala Leu Ser Pro Val Ile Cys Gly Pro Asn Arg Ser Phe Leu Ser
805 810 815
Leu Lys His Thr Pro Met Gly Lys Lys Ser Arg Arg Pro Ser Ala Lys
820 825 830
Ser Thr Met Pro Thr Ser Leu Pro Asn Leu Ala Lys Glu Ala Lys Asp
835 840 845
Ala Lys Gly Ser Arg Arg Lys Lys Ser Leu Ser Glu Lys Val Gln Leu
850 855 860
Ser Glu Ser Ser Val Thr Leu Ser Pro Val Asp Ser Leu Glu Ser Pro
865 870 875 880
His Thr Tyr Val Ser Asp Thr Thr Ser Ser Pro Met Ile Thr Ser Pro
885 890 895
Gly Ile Leu Gln Ala Ser Pro Asn Pro Met Leu Ala Thr Ala Ala Pro
900 905 910
Pro Ala Pro Val His Ala Gln His Ala Leu Ser Phe Ser Asn Leu His
915 920 925
Glu Met Gln Pro Leu Ala His Gly Ala Ser Thr Val Leu Pro Ser Val
930 935 940
Ser Gln Leu Leu Ser His His His Ile Val Ser Pro Gly Ser Gly Ser
945 950 955 960
Ala Gly Ser Leu Ser Arg Leu His Pro Val Pro Val Pro Ala Asp Trp
965 970 975
Met Asn Arg Met Glu Val Asn Glu Thr Gln Tyr Asn Glu Met Phe Gly
980 985 990
Met Val Leu Ala Pro Ala Glu Gly Thr His Pro Gly Ile Ala Pro Gln
995 1000 1005
Ser Arg Pro Pro Glu Gly Lys His Ile Thr Thr Pro Arg Glu Pro
1010 1015 1020
Leu Pro Pro Ile Val Thr Phe Gln Leu Ile Pro Lys Gly Ser Ile
1025 1030 1035
Ala Gln Pro Ala Gly Ala Pro Gln Pro Gln Ser Thr Cys Pro Pro
1040 1045 1050
Ala Val Ala Gly Pro Leu Pro Thr Met Tyr Gln Ile Pro Glu Met
1055 1060 1065
Ala Arg Leu Pro Ser Val Ala Phe Pro Thr Ala Met Met Pro Gln
1070 1075 1080
Gln Asp Gly Gln Val Ala Gln Thr Ile Leu Pro Ala Tyr His Pro
1085 1090 1095
Phe Pro Ala Ser Val Gly Lys Tyr Pro Thr Pro Pro Ser Gln His
1100 1105 1110
Ser Tyr Ala Ser Ser Asn Ala Ala Glu Arg Thr Pro Ser His Ser
1115 1120 1125
Gly His Leu Gln Gly Glu His Pro Tyr Leu Thr Pro Ser Pro Glu
1130 1135 1140
Ser Pro Asp Gln Trp Ser Ser Ser Ser Pro His Ser Ala Ser Asp
1145 1150 1155
Trp Ser Asp Val Thr Thr Ser Pro Thr Pro Gly Gly Ala Gly Gly
1160 1165 1170
Gly Gln Arg Gly Pro Gly Thr His Met Ser Glu Pro Pro His Asn
1175 1180 1185
Asn Met Gln Val Tyr Ala
1190
<210> 13
<211> 633
<212> DNA
<213> artificial
<220>
<223> SNAP25-tTA(pCMV-Tet3G)
<400> 13
gaattcacca tggccgaaga cgcagacatg cgcaatgagc tggaggagat gcagcgaagg 60
gctgaccagt tggctgatga gtcgctggaa agcacccgtc gtatgctgca actggttgaa 120
gagagtaaag atgctggtat caggactttg gttatgttgg atgaacaagg agaacaactg 180
gaacgcattg aggaagggat ggaccaaatc aataaggaca tgaaagaagc agaaaagaat 240
ttgacggacc taggaaaatt ctgcgggctt tgtgtgtgtc cctgtaacaa gcttaaatca 300
agtgatgctt acaaaaaagc ctggggcaat aatcaggacg gagtggtggc cagccagcct 360
gctcgtgtag tggacgaacg ggagcagatg gccatcagtg gcggcttcat ccgcagggta 420
acaaatgatg cccgagaaaa tgaaatggat gaaaacctag agcaggtgag cggcatcatc 480
gggaacctcc gtcacatggc cctggatatg ggcaatgaga tcgatacaca gaatcgccag 540
atcgacagga tcatggagaa ggctgattcc aacaaaacca gaattgatga ggccaaccaa 600
cgtgcaacaa agatgctggg aagtggttct aga 633
<210> 14
<211> 453
<212> PRT
<213> artificial
<220>
<223> SNAP25-tTA(pCMV-Tet3G)
<400> 14
Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg
1 5 10 15
Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met
20 25 30
Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val
35 40 45
Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met
50 55 60
Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp
65 70 75 80
Leu Gly Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys
85 90 95
Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val
100 105 110
Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala
115 120 125
Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn
130 135 140
Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu
145 150 155 160
Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg
165 170 175
Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile
180 185 190
Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly Ser Arg
195 200 205
Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Gly
210 215 220
Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly
225 230 235 240
Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu
245 250 255
Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His Thr His Ser
260 265 270
Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala
275 280 285
Lys Ser Tyr Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val
290 295 300
His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn
305 310 315 320
Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu
325 330 335
Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu
340 345 350
Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr
355 360 365
Asp Ser Met Pro Pro Leu Leu Lys Gln Ala Ile Glu Leu Phe Asp Arg
370 375 380
Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys
385 390 395 400
Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Thr Asp Ala
405 410 415
Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp
420 425 430
Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu
435 440 445
Asp Met Leu Pro Gly
450
<210> 15
<211> 1290
<212> DNA
<213> artificial
<220>
<223> GST-SNAP25-tTA (2)(pCMV-Tet3G)
<400> 15
gaattcacca tgtcccctat actaggttat tggaaaatta agggccttgt gcaacccact 60
cgacttcttt tggaatatct tgaagaaaaa tatgaagagc atttgtatga gcgcgatgaa 120
ggtgataaat ggcgaaacaa aaagtttgaa ttgggtttgg agtttcccaa tcttccttat 180
tatattgatg gtgatgttaa attaacacag tctatggcca tcatacgtta tatagctgac 240
aagcacaaca tgttgggtgg ttgtccaaaa gagcgtgcag agatttcaat gcttgaagga 300
gcggttttgg atattagata cggtgtttcg agaattgcat atagtaaaga ctttgaaact 360
ctcaaagttg attttcttag caagctacct gaaatgctga aaatgttcga agatcgttta 420
tgtcataaaa catatttaaa tggtgatcat gtaacccatc ctgacttcat gttgtatgac 480
gctcttgatg ttgttttata catggaccca atgtgcctgg atgcgttccc aaaattagtt 540
tgttttaaaa aacgtattga agctatccca caaattgata agtacttgaa atccagcaag 600
tatatagcat ggcctttgca gggctggcaa gccacgtttg gtggtggcga ccatcctcca 660
aaatcggatg ccgaagacgc agacatgcgc aatgagctgg aggagatgca gcgaagggct 720
gaccagttgg ctgatgagtc gctggaaagc acccgtcgta tgctgcaact ggttgaagag 780
agtaaagatg ctggtatcag gactttggtt atgttggatg aacaaggaga acaactggaa 840
cgcattgagg aagggatgga ccaaatcaat aaggacatga aagaagcaga aaagaatttg 900
acggacctag gaaaattctg cgggctttgt gtgtgtccct gtaacaagct taaatcaagt 960
gatgcttaca aaaaagcctg gggcaataat caggacggag tggtggccag ccagcctgct 1020
cgtgtagtgg acgaacggga gcagatggcc atcagtggcg gcttcatccg cagggtaaca 1080
aatgatgccc gagaaaatga aatggatgaa aacctagagc aggtgagcgg catcatcggg 1140
aacctccgtc acatggccct ggatatgggc aatgagatcg atacacagaa tcgccagatc 1200
gacaggatca tggagaaggc tgattccaac aaaaccagaa ttgatgaggc caaccaacgt 1260
gcaacaaaga tgctgggaag tggttctaga 1290
<210> 16
<211> 672
<212> PRT
<213> artificial
<220>
<223> GST-SNAP25-tTA (2)(pCMV-Tet3G)
<400> 16
Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro
1 5 10 15
Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu
20 25 30
Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu
35 40 45
Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys
50 55 60
Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn
65 70 75 80
Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu
85 90 95
Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser
100 105 110
Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu
115 120 125
Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn
130 135 140
Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp
145 150 155 160
Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu
165 170 175
Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr
180 185 190
Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala
195 200 205
Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Ala Glu Asp Ala
210 215 220
Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg Arg Ala Asp Gln Leu
225 230 235 240
Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met Leu Gln Leu Val Glu
245 250 255
Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val Met Leu Asp Glu Gln
260 265 270
Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met Asp Gln Ile Asn Lys
275 280 285
Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp Leu Gly Lys Phe Cys
290 295 300
Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys Ser Ser Asp Ala Tyr
305 310 315 320
Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val Val Ala Ser Gln Pro
325 330 335
Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala Ile Ser Gly Gly Phe
340 345 350
Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn Glu Met Asp Glu Asn
355 360 365
Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu Arg His Met Ala Leu
370 375 380
Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile Asp Arg Ile
385 390 395 400
Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile Asp Glu Ala Asn Gln
405 410 415
Arg Ala Thr Lys Met Leu Gly Ser Gly Ser Arg Leu Asp Lys Ser Lys
420 425 430
Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Gly Val Gly Ile Glu Gly
435 440 445
Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu Gln Pro Thr
450 455 460
Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu Pro
465 470 475 480
Ile Glu Met Leu Asp Arg His His Thr His Ser Cys Pro Leu Glu Gly
485 490 495
Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser Tyr Arg Cys
500 505 510
Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His Leu Gly Thr Arg
515 520 525
Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe Leu
530 535 540
Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser Ala
545 550 555 560
Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Glu Gln Glu His Gln
565 570 575
Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser Met Pro Pro
580 585 590
Leu Leu Lys Gln Ala Ile Glu Leu Phe Asp Arg Gln Gly Ala Glu Pro
595 600 605
Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys Gln
610 615 620
Leu Lys Cys Glu Ser Gly Gly Pro Thr Asp Ala Leu Asp Asp Phe Asp
625 630 635 640
Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met
645 650 655
Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly
660 665 670
<210> 17
<211> 2094
<212> DNA
<213> artificial
<220>
<223> GFP-SNAP25-tTA(pcDNA3.1)
<400> 17
cttaaggcca ccatggccag caaaggagaa gaacttttca ctggagttgt cccaattctt 60
gttgaattag atggtgatgt taatgggcac aaattttctg tcagtggaga gggtgaaggt 120
gatgctacat acggaaagct tacccttaaa tttatttgca ctactggaaa actacctgtt 180
ccatggccaa cacttgtcac tactttctct tatggtgttc aatgcttttc ccgttatccg 240
gatcatatga aacggcatga ctttttcaag agtgccatgc ccgaaggtta tgtacaggaa 300
cgcactatat ctttcaaaga tgacgggaac tacaagacgc gtgctgaagt caagtttgaa 360
ggtgataccc ttgttaatcg tatcgagtta aaaggtattg attttaaaga agatggaaac 420
attctcggac acaaactgga gtacaactat aactcacaca atgtatacat cacggcagac 480
aaacaaaaga atggaatcaa agctaacttc aaaattcgcc acaacattga agatggatcc 540
gttcaactag cagaccatta tcaacaaaat actccaattg gcgatggccc tgtcctttta 600
ccagacaacc attacctgtc gacacaatct gccctttcga aagatcccaa cgaaaagcgt 660
gaccacatgg tccttcttga gtttgtaact gctgctggga ttacacatgg catggatgag 720
ctctacaaag ccgaagacgc agacatgcgc aatgagctgg aggagatgca gcgaagggct 780
gaccagttgg ctgatgagtc gctggaaagc acccgtcgta tgctgcaact ggttgaagag 840
agtaaagatg ctggtatcag gactttggtt atgttggatg aacaaggaga acaactggaa 900
cgcattgagg aagggatgga ccaaatcaat aaggacatga aagaagcaga aaagaatttg 960
acggacctag gaaaattctg cgggctttgt gtgtgtccct gtaacaagct taaatcaagt 1020
gatgcttaca aaaaagcctg gggcaataat caggacggag tggtggccag ccagcctgct 1080
cgtgtagtgg acgaacggga gcagatggcc atcagtggcg gcttcatccg cagggtaaca 1140
aatgatgccc gagaaaatga aatggatgaa aacctagagc aggtgagcgg catcatcggg 1200
aacctccgtc acatggccct ggatatgggc aatgagatcg atacacagaa tcgccagatc 1260
gacaggatca tggagaaggc tgattccaac aaaaccagaa ttgatgaggc caaccaacgt 1320
gcaacaaaga tgctgggaag tggttctaga ctggacaaga gcaaagtcat aaactctgct 1380
ctggaattac tcaatggagt cggtatcgaa ggcctgacga caaggaaact cgctcaaaag 1440
ctgggagttg agcagcctac cctgtactgg cacgtgaaga acaagcgggc cctgctcgat 1500
gccctgccaa tcgagatgct ggacaggcat catacccact cctgccccct ggaaggcgag 1560
tcatggcaag actttctgcg gaacaacgcc aagtcatacc gctgtgctct cctctcacat 1620
cgcgacgggg ctaaagtgca tctcggcacc cgcccaacag agaaacagta cgaaaccctg 1680
gaaaatcagc tcgcgttcct gtgtcagcaa ggcttctccc tggagaacgc actgtacgct 1740
ctgtccgccg tgggccactt tacactgggc tgcgtattgg aggaacagga gcatcaagta 1800
gcaaaagagg aaagagagac acctaccacc gattctatgc ccccacttct gaaacaagca 1860
attgagctgt tcgaccggca gggagccgaa cctgccttcc ttttcggcct ggaactaatc 1920
atatgtggcc tggagaaaca gctaaagtgc gaaagcggcg ggccgaccga cgcccttgac 1980
gattttgact tagacatgct cccagccgat gcccttgacg actttgacct tgatatgctg 2040
cctgctgacg ctcttgacga ttttgacctt gacatgctcc ccgggtaact cgag 2094
<210> 18
<211> 691
<212> PRT
<213> artificial
<220>
<223> GFP-SNAP25-tTA(pcDNA3.1)
<400> 18
Met Ala Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu
1 5 10 15
Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly
20 25 30
Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile
35 40 45
Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr
50 55 60
Phe Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys
65 70 75 80
Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu
85 90 95
Arg Thr Ile Ser Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu
100 105 110
Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly
115 120 125
Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr
130 135 140
Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn
145 150 155 160
Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser
165 170 175
Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly
180 185 190
Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu
195 200 205
Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe
210 215 220
Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Ala
225 230 235 240
Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg Arg Ala
245 250 255
Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met Leu Gln
260 265 270
Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val Met Leu
275 280 285
Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met Asp Gln
290 295 300
Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp Leu Gly
305 310 315 320
Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys Ser Ser
325 330 335
Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val Val Ala
340 345 350
Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala Ile Ser
355 360 365
Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn Glu Met
370 375 380
Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu Arg His
385 390 395 400
Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile
405 410 415
Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile Asp Glu
420 425 430
Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly Ser Arg Leu Asp
435 440 445
Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Gly Val Gly
450 455 460
Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu
465 470 475 480
Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp
485 490 495
Ala Leu Pro Ile Glu Met Leu Asp Arg His His Thr His Ser Cys Pro
500 505 510
Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser
515 520 525
Tyr Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His Leu
530 535 540
Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu
545 550 555 560
Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala
565 570 575
Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Glu Gln
580 585 590
Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser
595 600 605
Met Pro Pro Leu Leu Lys Gln Ala Ile Glu Leu Phe Asp Arg Gln Gly
610 615 620
Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu
625 630 635 640
Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Thr Asp Ala Leu Asp
645 650 655
Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp
660 665 670
Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met
675 680 685
Leu Pro Gly
690
<210> 19
<211> 1731
<212> DNA
<213> artificial
<220>
<223> MBP-SNAP25-tTA (2)(pCMV-Tet3G)
<400> 19
gaattcacca tgaagaccga ggagggcaag ctggtgatct ggatcaacgg cgacaagggc 60
tacaacggcc tggccgaggt gggcaagaag ttcgagaagg acaccggcat caaggtgacc 120
gtggagcacc ccgacaagct ggaggagaag ttcccccagg tggccgccac cggcgacggc 180
cccgacatca tcttctgggc ccacgacaga ttcggcggct acgcccagag cggcctgctg 240
gccgagatca cccccgacaa ggccttccag gacaagctgt accccttcac ctgggacgcc 300
gtgagataca acggcaagct gatcgcctac cccatcgccg tggaggccct gagcctgatc 360
tacaacaagg acctgctgcc caaccccccc aagacctggg aggagatccc cgccctggac 420
aaggagctga aggccaaggg caagagcgcc ctgatgttca acctgcagga gccctacttc 480
acctggcccc tgatcgccgc cgacggcggc tacgccttca agtacgagaa cggcaagtac 540
gacatcaagg acgtgggcgt ggacaacgcc ggcgccaagg ccggcctgac cttcctggtg 600
gacctgatca agaacaagca catgaacgcc gacaccgact acagcatcgc cgaggccgcc 660
ttcaacaagg gcgagaccgc catgaccatc aacggcccct gggcctggag caacatcgac 720
accagcaagg tgaactacgg cgtgaccgtg ctgcccacct tcaagggcca gcccagcaag 780
cccttcgtgg gcgtgctgag cgccggcatc aacgccgcca gccccaacaa ggagctggcc 840
aaggagttcc tggagaacta cctgctgacc gacgagggcc tggaggccgt gaacaaggac 900
aagcccctgg gcgccgtggc cctgaagagc tacgaggagg agctggccaa ggaccccaga 960
atcgccgcca ccatggagaa cgcccagaag ggcgagatca tgcccaacat cccccagatg 1020
agcgccttct ggtacgccgt gagaaccgcc gtgatcaacg ccgccagcgg cagacagacc 1080
gtggacgagg ccctgaagga cgcccagacc gccgaagacg cagacatgcg caatgagctg 1140
gaggagatgc agcgaagggc tgaccagttg gctgatgagt cgctggaaag cacccgtcgt 1200
atgctgcaac tggttgaaga gagtaaagat gctggtatca ggactttggt tatgttggat 1260
gaacaaggag aacaactgga acgcattgag gaagggatgg accaaatcaa taaggacatg 1320
aaagaagcag aaaagaattt gacggaccta ggaaaattct gcgggctttg tgtgtgtccc 1380
tgtaacaagc ttaaatcaag tgatgcttac aaaaaagcct ggggcaataa tcaggacgga 1440
gtggtggcca gccagcctgc tcgtgtagtg gacgaacggg agcagatggc catcagtggc 1500
ggcttcatcc gcagggtaac aaatgatgcc cgagaaaatg aaatggatga aaacctagag 1560
caggtgagcg gcatcatcgg gaacctccgt cacatggccc tggatatggg caatgagatc 1620
gatacacaga atcgccagat cgacaggatc atggagaagg ctgattccaa caaaaccaga 1680
attgatgagg ccaaccaacg tgcaacaaag atgctgggaa gtggttctag a 1731
<210> 20
<211> 819
<212> PRT
<213> artificial
<220>
<223> MBP-SNAP25-tTA (2) (pCMV-Tet3G)
<400> 20
Met Lys Thr Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys
1 5 10 15
Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr
20 25 30
Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe
35 40 45
Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala
50 55 60
His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile
65 70 75 80
Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp
85 90 95
Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu
100 105 110
Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys
115 120 125
Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly
130 135 140
Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro
145 150 155 160
Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys
165 170 175
Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly
180 185 190
Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp
195 200 205
Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala
210 215 220
Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys
225 230 235 240
Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser
245 250 255
Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro
260 265 270
Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp
275 280 285
Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala
290 295 300
Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala
305 310 315 320
Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln
325 330 335
Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala
340 345 350
Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Ala
355 360 365
Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg Arg Ala
370 375 380
Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met Leu Gln
385 390 395 400
Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val Met Leu
405 410 415
Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met Asp Gln
420 425 430
Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp Leu Gly
435 440 445
Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys Ser Ser
450 455 460
Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val Val Ala
465 470 475 480
Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala Ile Ser
485 490 495
Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn Glu Met
500 505 510
Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu Arg His
515 520 525
Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile
530 535 540
Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile Asp Glu
545 550 555 560
Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly Ser Arg Leu Asp
565 570 575
Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Gly Val Gly
580 585 590
Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu
595 600 605
Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp
610 615 620
Ala Leu Pro Ile Glu Met Leu Asp Arg His His Thr His Ser Cys Pro
625 630 635 640
Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser
645 650 655
Tyr Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His Leu
660 665 670
Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu
675 680 685
Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala
690 695 700
Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Glu Gln
705 710 715 720
Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser
725 730 735
Met Pro Pro Leu Leu Lys Gln Ala Ile Glu Leu Phe Asp Arg Gln Gly
740 745 750
Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu
755 760 765
Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Thr Asp Ala Leu Asp
770 775 780
Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp
785 790 795 800
Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met
805 810 815
Leu Pro Gly
<210> 21
<211> 1089
<212> DNA
<213> artificial
<220>
<223> CLAT-SNAP25-tTA (1)(pCMV-Tet3G)
<400> 21
gaattcacca tggctgagct ggatccgttc ggcgcccctg ccggcgcccc tggcggtccc 60
gcgctgggga acggagtggc cggcgccggc gaagaagacc cggctgcggc cttcttggcg 120
cagcaagaga gcgagattgc gggcatcgag aacgacgagg ccttcgccat cctggacggc 180
ggcgcccccg ggccccagcc gcacggcgag ccgccggggg gtccggatgc tgttgatgga 240
gtaatgaatg gtgaatacta ccaggaaagt aatggtccaa cagacagtta tgcagctatt 300
tcacaagtgg atcgattgca gtcagagcct gaaagtatcc gtaaatggag agaagaacaa 360
atggaacgct tggaagccct tgatgccaat tctcggaagc aagaagcaga gtggaaagaa 420
aaggcaataa aggagctaga agaatggtat gcaagacagg acgagcagct acagaaaaca 480
aaagcaaaca acagggtggc agatgaagct ttctacaaac aacccttcgc tgacgtgatt 540
ggttatgtca caaacataaa ccatccttgc tacagcctag aacaggcagc agaagaagcc 600
tttgtaaatg acattgacga gtcgtcccca ggcactgagt gggaacgggt ggcccggctg 660
tgtgacttta accccaagtc tagcaagcag gccaaagatg tctcccgcat gcgctcagtc 720
ctcatctccc tcaagcaggc cccgctggtg cactcaagtg atgcttacaa aaaagcctgg 780
ggcaataatc aggacggagt ggtggccagc cagcctgctc gtgtagtgga cgaacgggag 840
cagatggcca tcagtggcgg cttcatccgc agggtaacaa atgatgcccg agaaaatgaa 900
atggatgaaa acctagagca ggtgagcggc atcatcggga acctccgtca catggccctg 960
gatatgggca atgagatcga tacacagaat cgccagatcg acaggatcat ggagaaggct 1020
gattccaaca aaaccagaat tgatgaggcc aaccaacgtg caacaaagat gctgggaagt 1080
ggttctaga 1089
<210> 22
<211> 605
<212> PRT
<213> artificial
<220>
<223> CLAT-SNAP25-tTA (1)(pCMV-Tet3G)
<400> 22
Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly
1 5 10 15
Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala
20 25 30
Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn
35 40 45
Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Pro
50 55 60
His Gly Glu Pro Pro Gly Gly Pro Asp Ala Val Asp Gly Val Met Asn
65 70 75 80
Gly Glu Tyr Tyr Gln Glu Ser Asn Gly Pro Thr Asp Ser Tyr Ala Ala
85 90 95
Ile Ser Gln Val Asp Arg Leu Gln Ser Glu Pro Glu Ser Ile Arg Lys
100 105 110
Trp Arg Glu Glu Gln Met Glu Arg Leu Glu Ala Leu Asp Ala Asn Ser
115 120 125
Arg Lys Gln Glu Ala Glu Trp Lys Glu Lys Ala Ile Lys Glu Leu Glu
130 135 140
Glu Trp Tyr Ala Arg Gln Asp Glu Gln Leu Gln Lys Thr Lys Ala Asn
145 150 155 160
Asn Arg Val Ala Asp Glu Ala Phe Tyr Lys Gln Pro Phe Ala Asp Val
165 170 175
Ile Gly Tyr Val Thr Asn Ile Asn His Pro Cys Tyr Ser Leu Glu Gln
180 185 190
Ala Ala Glu Glu Ala Phe Val Asn Asp Ile Asp Glu Ser Ser Pro Gly
195 200 205
Thr Glu Trp Glu Arg Val Ala Arg Leu Cys Asp Phe Asn Pro Lys Ser
210 215 220
Ser Lys Gln Ala Lys Asp Val Ser Arg Met Arg Ser Val Leu Ile Ser
225 230 235 240
Leu Lys Gln Ala Pro Leu Val His Ser Ser Asp Ala Tyr Lys Lys Ala
245 250 255
Trp Gly Asn Asn Gln Asp Gly Val Val Ala Ser Gln Pro Ala Arg Val
260 265 270
Val Asp Glu Arg Glu Gln Met Ala Ile Ser Gly Gly Phe Ile Arg Arg
275 280 285
Val Thr Asn Asp Ala Arg Glu Asn Glu Met Asp Glu Asn Leu Glu Gln
290 295 300
Val Ser Gly Ile Ile Gly Asn Leu Arg His Met Ala Leu Asp Met Gly
305 310 315 320
Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys
325 330 335
Ala Asp Ser Asn Lys Thr Arg Ile Asp Glu Ala Asn Gln Arg Ala Thr
340 345 350
Lys Met Leu Gly Ser Gly Ser Arg Leu Asp Lys Ser Lys Val Ile Asn
355 360 365
Ser Ala Leu Glu Leu Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr
370 375 380
Arg Lys Leu Ala Gln Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp
385 390 395 400
His Val Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met
405 410 415
Leu Asp Arg His His Thr His Ser Cys Pro Leu Glu Gly Glu Ser Trp
420 425 430
Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser Tyr Arg Cys Ala Leu Leu
435 440 445
Ser His Arg Asp Gly Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu
450 455 460
Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln
465 470 475 480
Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His
485 490 495
Phe Thr Leu Gly Cys Val Leu Glu Glu Gln Glu His Gln Val Ala Lys
500 505 510
Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Lys
515 520 525
Gln Ala Ile Glu Leu Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu
530 535 540
Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys
545 550 555 560
Glu Ser Gly Gly Pro Thr Asp Ala Leu Asp Asp Phe Asp Leu Asp Met
565 570 575
Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala
580 585 590
Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly
595 600 605
<210> 23
<211> 3731
<212> DNA
<213> artificial
<220>
<223> tTA-SNAP25-SV2 (pCMV-Tet3G)
<400> 23
gaattcacca tgtctagact ggacaagagc aaagtcataa actctgctct ggaattactc 60
aatggagtcg gtatcgaagg cctgacgaca aggaaactcg ctcaaaagct gggagttgag 120
cagcctaccc tgtactggca cgtgaagaac aagcgggccc tgctcgatgc cctgccaatc 180
gagatgctgg acaggcatca tacccactcc tgccccctgg aaggcgagtc atggcaagac 240
tttctgcgga acaacgccaa gtcataccgc tgtgctctcc tctcacatcg cgacggggct 300
aaagtgcatc tcggcacccg cccaacagag aaacagtacg aaaccctgga aaatcagctc 360
gcgttcctgt gtcagcaagg cttctccctg gagaacgcac tgtacgctct gtccgccgtg 420
ggccacttta cactgggctg cgtattggag gaacaggagc atcaagtagc aaaagaggaa 480
agagagacac ctaccaccga ttctatgccc ccacttctga aacaagcaat tgagctgttc 540
gaccggcagg gagccgaacc tgccttcctt ttcggcctgg aactaatcat atgtggcctg 600
gagaaacagc taaagtgcga aagcggcggg ccgaccgacg cccttgacga ttttgactta 660
gacatgctcc cagccgatgc ccttgacgac tttgaccttg atatgctgcc tgctgacgct 720
cttgacgatt ttgaccttga catgctcccc ggggccggcg ccggcagcgg agtggtggcc 780
agccagcctg ctcgtgtagt ggacgaacgg gagcagatgg ccatcagtgg cggcttcatc 840
cgcagggtaa caaatgatgc ccgagaaaat gaaatggatg aaaacctaga gcaggtgagc 900
ggcatcatcg ggaacctccg tcacatggcc ctggatatgg gcaatgagat cgatacacag 960
aatcgccaga tcgacaggat catggagaag gctgattcca acaaaaccag aattgatgag 1020
gccaaccaac gtgcaacaaa gatgctggga agtggtgccg gcgccggcag cgaagactct 1080
tacaaggata ggacttcact gatgaagggt gccaaggaca ttgccagaga ggtgaagaaa 1140
caaacagtaa agaaggtgaa tcaagctgtg gaccgagccc aggatgaata cacccagagg 1200
tcctacagtc ggttccaaga tgaagaagat gatgatgact actacccggc tggagaaacc 1260
tataatggtg aggccaacga tgacgaaggc tcaagtgaag ccactgaggg gcatgatgaa 1320
gatgatgaga tctatgaggg ggagtatcag ggcatcccca gtatgaacca agcgaaggac 1380
agcatcgtgt cagtggggca gcccaagggc gatgagtaca aggaccgacg ggagctggaa 1440
tcagaaagga gagctgacga ggaagagtta gcccagcagt atgagctgat aatccaagaa 1500
tgcggtcatg gtcgttttca gtgggccctt ttcttcgtcc tgggcatggc tcttatggca 1560
gacggtgtag aggtgtttgt cgttggcttc gtgttaccca gtgctgagac agacctctgc 1620
atcccaaatt caggatctgg atggctaggc agcatagtgt acctcgggat gatggtgggg 1680
gcgttcttct ggggaggact ggcagacaaa gtgggaagga aacagtctct tctgatttgc 1740
atgtctgtca acggattctt tgccttcctt tcttcatttg tccaaggtta tggcttcttt 1800
ctcttctgtc gcttactttc tggattcggg attggaggag ccatacccac tgtgttctcg 1860
tactttgctg aagtcctggc ccgggaaaag cggggcgaac acttgagctg gctctgcatg 1920
ttctggatga tcggtggcat ctacgcctct gccatggcct gggccatcat cccgcactac 1980
gggtggagct tcagcatggg atcggcctac cagtttcaca gttggcgtgt gtttgtcatc 2040
gtctgtgcac tcccctgtgt ctcctccgtg gtggccctca cattcatgcc tgaaagccca 2100
cgattcttgt tggaggttgg aaaacatgat gaagcttgga tgattctgaa gttaattcat 2160
gacaccaaca tgagagcccg gggtcagcct gagaaggtct tcacggtaaa caaaataaaa 2220
actcctaaac aaatagatga gctgattgaa attgagagtg acacaggaac atggtatagg 2280
aggtgttttg ttcggatccg caccgagctg tacggaattt ggttgacttt tatgagatgt 2340
ttcaactacc cagtcaggga taatacaata aagcttacaa ttgtttggtt caccctgtcc 2400
tttgggtact atggattatc cgtttggttc cctgatgtca ttaaacctct gcagtccgat 2460
gaatatgcat tgctaaccag aaatgtggag agagataaat atgcaaattt cactattaac 2520
tttacaatgg aaaatcagat tcatactgga atggaatacg acaatggcag attcataggg 2580
gtcaagttca aatctgtaac tttcaaagac tctgttttta agtcctgcac ctttgaggat 2640
gtaacttcag tgaacaccta cttcaagaac tgcacattta ttgacactgt ttttgacaac 2700
acagattttg agccatataa attcattgac agtgaattta aaaactgctc gttttttcac 2760
aacaagacgg gatgtcagat tacctttgat gatgactata gtgcctactg gatttatttt 2820
gtcaactttc tggggacatt ggcagtattg ccagggaaca ttgtgtctgc tctgctgatg 2880
gacagaattg ggcgcttaac aatgctaggt ggctctatgg tgctttcggg gatcagctgt 2940
ttcttccttt ggttcggcac cagtgaatcc atgatgatag gcatgctgtg tctgtacaat 3000
ggattgacca tctcagcctg gaactctctt gacgtggtca ctgtggaact gtaccccaca 3060
gaccggaggg caacaggctt tggcttctta aatgcgctat gcaaggcagc agccgtcctg 3120
ggaaacttaa tatttggctc tctggtcagc atcaccaaat caatccccat cctgctggct 3180
tctactgtgc tcgtgtgtgg aggactcgtt gggctgtgcc tgcctgacac acgaacccag 3240
gttctgtaac taagtaagga tccagacatg ataagataca ttgatgagtt tggacaaacc 3300
acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta 3360
tttgtaacca ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg 3420
tttcaggttc agggggaggt gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt 3480
ggtatggctg attatgatcc tgcaagcctc gtcgtcctgg ccggaccacg ctatctgtgc 3540
aaggtccccg gccccggacg cgcgctccat gagcagagcg cccgccgccg aggcgaagac 3600
tcgggcggcg ccctgcccgt cccaccaggt caacaggcgg taaccggcct cttcatcggg 3660
aatgcgcgcg accttcagca tcgccggcat gtccccctgg cggacgggaa gtatccagct 3720
cgaccaagct t 3731
<210> 24
<211> 1079
<212> PRT
<213> artificial
<220>
<223> tTA-SNAP25-SV2(pCMV-TEt3G)
<400> 24
Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu
1 5 10 15
Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln
20 25 30
Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys
35 40 45
Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His
50 55 60
Thr His Ser Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg
65 70 75 80
Asn Asn Ala Lys Ser Tyr Arg Cys Ala Leu Leu Ser His Arg Asp Gly
85 90 95
Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr
100 105 110
Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu
115 120 125
Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys
130 135 140
Val Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr
145 150 155 160
Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Lys Gln Ala Ile Glu Leu
165 170 175
Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu
180 185 190
Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro
195 200 205
Thr Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala
210 215 220
Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp
225 230 235 240
Phe Asp Leu Asp Met Leu Pro Gly Ala Gly Ala Gly Ser Gly Val Val
245 250 255
Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala Ile
260 265 270
Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn Glu
275 280 285
Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu Arg
290 295 300
His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln
305 310 315 320
Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile Asp
325 330 335
Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly Ala Gly Ala
340 345 350
Gly Ser Glu Asp Ser Tyr Lys Asp Arg Thr Ser Leu Met Lys Gly Ala
355 360 365
Lys Asp Ile Ala Arg Glu Val Lys Lys Gln Thr Val Lys Lys Val Asn
370 375 380
Gln Ala Val Asp Arg Ala Gln Asp Glu Tyr Thr Gln Arg Ser Tyr Ser
385 390 395 400
Arg Phe Gln Asp Glu Glu Asp Asp Asp Asp Tyr Tyr Pro Ala Gly Glu
405 410 415
Thr Tyr Asn Gly Glu Ala Asn Asp Asp Glu Gly Ser Ser Glu Ala Thr
420 425 430
Glu Gly His Asp Glu Asp Asp Glu Ile Tyr Glu Gly Glu Tyr Gln Gly
435 440 445
Ile Pro Ser Met Asn Gln Ala Lys Asp Ser Ile Val Ser Val Gly Gln
450 455 460
Pro Lys Gly Asp Glu Tyr Lys Asp Arg Arg Glu Leu Glu Ser Glu Arg
465 470 475 480
Arg Ala Asp Glu Glu Glu Leu Ala Gln Gln Tyr Glu Leu Ile Ile Gln
485 490 495
Glu Cys Gly His Gly Arg Phe Gln Trp Ala Leu Phe Phe Val Leu Gly
500 505 510
Met Ala Leu Met Ala Asp Gly Val Glu Val Phe Val Val Gly Phe Val
515 520 525
Leu Pro Ser Ala Glu Thr Asp Leu Cys Ile Pro Asn Ser Gly Ser Gly
530 535 540
Trp Leu Gly Ser Ile Val Tyr Leu Gly Met Met Val Gly Ala Phe Phe
545 550 555 560
Trp Gly Gly Leu Ala Asp Lys Val Gly Arg Lys Gln Ser Leu Leu Ile
565 570 575
Cys Met Ser Val Asn Gly Phe Phe Ala Phe Leu Ser Ser Phe Val Gln
580 585 590
Gly Tyr Gly Phe Phe Leu Phe Cys Arg Leu Leu Ser Gly Phe Gly Ile
595 600 605
Gly Gly Ala Ile Pro Thr Val Phe Ser Tyr Phe Ala Glu Val Leu Ala
610 615 620
Arg Glu Lys Arg Gly Glu His Leu Ser Trp Leu Cys Met Phe Trp Met
625 630 635 640
Ile Gly Gly Ile Tyr Ala Ser Ala Met Ala Trp Ala Ile Ile Pro His
645 650 655
Tyr Gly Trp Ser Phe Ser Met Gly Ser Ala Tyr Gln Phe His Ser Trp
660 665 670
Arg Val Phe Val Ile Val Cys Ala Leu Pro Cys Val Ser Ser Val Val
675 680 685
Ala Leu Thr Phe Met Pro Glu Ser Pro Arg Phe Leu Leu Glu Val Gly
690 695 700
Lys His Asp Glu Ala Trp Met Ile Leu Lys Leu Ile His Asp Thr Asn
705 710 715 720
Met Arg Ala Arg Gly Gln Pro Glu Lys Val Phe Thr Val Asn Lys Ile
725 730 735
Lys Thr Pro Lys Gln Ile Asp Glu Leu Ile Glu Ile Glu Ser Asp Thr
740 745 750
Gly Thr Trp Tyr Arg Arg Cys Phe Val Arg Ile Arg Thr Glu Leu Tyr
755 760 765
Gly Ile Trp Leu Thr Phe Met Arg Cys Phe Asn Tyr Pro Val Arg Asp
770 775 780
Asn Thr Ile Lys Leu Thr Ile Val Trp Phe Thr Leu Ser Phe Gly Tyr
785 790 795 800
Tyr Gly Leu Ser Val Trp Phe Pro Asp Val Ile Lys Pro Leu Gln Ser
805 810 815
Asp Glu Tyr Ala Leu Leu Thr Arg Asn Val Glu Arg Asp Lys Tyr Ala
820 825 830
Asn Phe Thr Ile Asn Phe Thr Met Glu Asn Gln Ile His Thr Gly Met
835 840 845
Glu Tyr Asp Asn Gly Arg Phe Ile Gly Val Lys Phe Lys Ser Val Thr
850 855 860
Phe Lys Asp Ser Val Phe Lys Ser Cys Thr Phe Glu Asp Val Thr Ser
865 870 875 880
Val Asn Thr Tyr Phe Lys Asn Cys Thr Phe Ile Asp Thr Val Phe Asp
885 890 895
Asn Thr Asp Phe Glu Pro Tyr Lys Phe Ile Asp Ser Glu Phe Lys Asn
900 905 910
Cys Ser Phe Phe His Asn Lys Thr Gly Cys Gln Ile Thr Phe Asp Asp
915 920 925
Asp Tyr Ser Ala Tyr Trp Ile Tyr Phe Val Asn Phe Leu Gly Thr Leu
930 935 940
Ala Val Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp Arg Ile
945 950 955 960
Gly Arg Leu Thr Met Leu Gly Gly Ser Met Val Leu Ser Gly Ile Ser
965 970 975
Cys Phe Phe Leu Trp Phe Gly Thr Ser Glu Ser Met Met Ile Gly Met
980 985 990
Leu Cys Leu Tyr Asn Gly Leu Thr Ile Ser Ala Trp Asn Ser Leu Asp
995 1000 1005
Val Val Thr Val Glu Leu Tyr Pro Thr Asp Arg Arg Ala Thr Gly
1010 1015 1020
Phe Gly Phe Leu Asn Ala Leu Cys Lys Ala Ala Ala Val Leu Gly
1025 1030 1035
Asn Leu Ile Phe Gly Ser Leu Val Ser Ile Thr Lys Ser Ile Pro
1040 1045 1050
Ile Leu Leu Ala Ser Thr Val Leu Val Cys Gly Gly Leu Val Gly
1055 1060 1065
Leu Cys Leu Pro Asp Thr Arg Thr Gln Val Leu
1070 1075
<210> 25
<211> 3311
<212> DNA
<213> artificial
<220>
<223> tTA-SNAP25-Cholinetransporter(pCMV-Tet3G)
<400> 25
gaattcacca tgtctagact ggacaagagc aaagtcataa actctgctct ggaattactc 60
aatggagtcg gtatcgaagg cctgacgaca aggaaactcg ctcaaaagct gggagttgag 120
cagcctaccc tgtactggca cgtgaagaac aagcgggccc tgctcgatgc cctgccaatc 180
gagatgctgg acaggcatca tacccactcc tgccccctgg aaggcgagtc atggcaagac 240
tttctgcgga acaacgccaa gtcataccgc tgtgctctcc tctcacatcg cgacggggct 300
aaagtgcatc tcggcacccg cccaacagag aaacagtacg aaaccctgga aaatcagctc 360
gcgttcctgt gtcagcaagg cttctccctg gagaacgcac tgtacgctct gtccgccgtg 420
ggccacttta cactgggctg cgtattggag gaacaggagc atcaagtagc aaaagaggaa 480
agagagacac ctaccaccga ttctatgccc ccacttctga aacaagcaat tgagctgttc 540
gaccggcagg gagccgaacc tgccttcctt ttcggcctgg aactaatcat atgtggcctg 600
gagaaacagc taaagtgcga aagcggcggg ccgaccgacg cccttgacga ttttgactta 660
gacatgctcc cagccgatgc ccttgacgac tttgaccttg atatgctgcc tgctgacgct 720
cttgacgatt ttgaccttga catgctcccc ggggccggcg ccggcagcgg agtggtggcc 780
agccagcctg ctcgtgtagt ggacgaacgg gagcagatgg ccatcagtgg cggcttcatc 840
cgcagggtaa caaatgatgc ccgagaaaat gaaatggatg aaaacctaga gcaggtgagc 900
ggcatcatcg ggaacctccg tcacatggcc ctggatatgg gcaatgagat cgatacacag 960
aatcgccaga tcgacaggat catggagaag gctgattcca acaaaaccag aattgatgag 1020
gccaaccaac gtgcaacaaa gatgctggga agtggtgccg gcgccggcag cggcgccggc 1080
gccggcagcg ctttccatgt ggaaggactg atagctatca tcgtgttcta ccttctaatt 1140
ttgctggttg gaatatgggc tgcctggaga accaaaaaca gtggcagcgc agaagagcgc 1200
agcgaagcca tcatagttgg tggccgagat attggtttat tggttggtgg atttaccatg 1260
acagctacct gggtcggagg agggtatatc aatggcacag ctgaagcagt ttatgtacca 1320
ggttatggcc tagcttgggc tcaggcacca attggatatt ctcttagtct gattttaggt 1380
ggcctgttct ttgcaaaacc tatgcgttca aaggggtatg tgaccatgtt agacccgttt 1440
cagcaaatct atggaaaacg catgggcgga ctcctgttta ttcctgcact gatgggagaa 1500
atgttctggg ctgcagcaat tttctctgct ttgggagcca ccatcagcgt gatcatcgat 1560
gtggatatgc acatttctgt catcatctct gcactcattg ccactctgta cacactggtg 1620
ggagggctct attctgtggc ctacactgat gtcgttcagc tcttttgcat ttttgtaggg 1680
ctgtggatca gcgtcccctt tgcattgtca catcctgcag tcgcagacat cgggttcact 1740
gctgtgcatg ccaaatacca aaagccgtgg ctgggaactg ttgactcatc tgaagtctac 1800
tcttggcttg atagttttct gttgttgatg ctgggtggaa tcccatggca agcatacttt 1860
cagagggttc tctcttcttc ctcagccacc tatgctcaag tgctgtcctt cctggcagct 1920
ttcgggtgcc tggtgatggc catcccagcc atactcattg gggccattgg agcatcaaca 1980
gactggaacc agactgcata tgggcttcca gatcccaaga ctacagaaga ggcagacatg 2040
attttaccaa ttgttctgca gtatctctgc cctgtgtata tttctttctt tggtcttggt 2100
gcagtttctg ctgctgttat gtcatcagca gattcttcca tcttgtcagc aagttccatg 2160
tttgcacgga acatctacca gctttccttc agacaaaatg cttcggacaa agaaatcgtt 2220
tgggttatgc gaatcacagt gtttgtgttt ggagcatctg caacagccat ggccttgctg 2280
acgaaaactg tgtatgggct ctggtacctc agttctgacc ttgtttacat cgttatcttc 2340
ccccagctgc tttgtgtact ctttgttaag ggaaccaaca cctatggggc cgtggcaggt 2400
tatgtttctg gcctcttcct gagaataact ggaggggagc catatctgta tcttcagccc 2460
ttgatcttct accctggcta ttaccctgat gataatggta tatataatca gaaatttcca 2520
tttaaaacac ttgccatggt tacatcattc ttaaccaaca tttgcatctc ctatctagcc 2580
aagtatctat ttgaaagtgg aaccttgcca cctaaattag atgtatttga tgctgttgtt 2640
gcaagacaca gtgaagaaaa catggataag acaattcttg tcaaaaatga aaatattaaa 2700
ttagatgaac ttgcacttgt gaagccacga cagagcatga ccctcagctc aactttcacc 2760
aataaagagg ccttccttga tgttgattcc agtccagaag ggtctgggac tgaagataat 2820
ttacagtaac taagtaagga tccagacatg ataagataca ttgatgagtt tggacaaacc 2880
acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta 2940
tttgtaacca ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg 3000
tttcaggttc agggggaggt gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt 3060
ggtatggctg attatgatcc tgcaagcctc gtcgtcctgg ccggaccacg ctatctgtgc 3120
aaggtccccg gccccggacg cgcgctccat gagcagagcg cccgccgccg aggcgaagac 3180
tcgggcggcg ccctgcccgt cccaccaggt caacaggcgg taaccggcct cttcatcggg 3240
aatgcgcgcg accttcagca tcgccggcat gtccccctgg cggacgggaa gtatccagct 3300
cgaccaagct t 3311
<210> 26
<211> 939
<212> PRT
<213> artificial
<220>
<223> tTA-SNAP25-Cholinetransporter(pCMV-Tet3G)
<400> 26
Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu
1 5 10 15
Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln
20 25 30
Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys
35 40 45
Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His
50 55 60
Thr His Ser Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg
65 70 75 80
Asn Asn Ala Lys Ser Tyr Arg Cys Ala Leu Leu Ser His Arg Asp Gly
85 90 95
Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr
100 105 110
Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu
115 120 125
Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys
130 135 140
Val Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr
145 150 155 160
Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Lys Gln Ala Ile Glu Leu
165 170 175
Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu
180 185 190
Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro
195 200 205
Thr Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala
210 215 220
Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp
225 230 235 240
Phe Asp Leu Asp Met Leu Pro Gly Ala Gly Ala Gly Ser Gly Val Val
245 250 255
Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala Ile
260 265 270
Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn Glu
275 280 285
Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu Arg
290 295 300
His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln
305 310 315 320
Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile Asp
325 330 335
Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly Ala Gly Ala
340 345 350
Gly Ser Gly Ala Gly Ala Gly Ser Ala Phe His Val Glu Gly Leu Ile
355 360 365
Ala Ile Ile Val Phe Tyr Leu Leu Ile Leu Leu Val Gly Ile Trp Ala
370 375 380
Ala Trp Arg Thr Lys Asn Ser Gly Ser Ala Glu Glu Arg Ser Glu Ala
385 390 395 400
Ile Ile Val Gly Gly Arg Asp Ile Gly Leu Leu Val Gly Gly Phe Thr
405 410 415
Met Thr Ala Thr Trp Val Gly Gly Gly Tyr Ile Asn Gly Thr Ala Glu
420 425 430
Ala Val Tyr Val Pro Gly Tyr Gly Leu Ala Trp Ala Gln Ala Pro Ile
435 440 445
Gly Tyr Ser Leu Ser Leu Ile Leu Gly Gly Leu Phe Phe Ala Lys Pro
450 455 460
Met Arg Ser Lys Gly Tyr Val Thr Met Leu Asp Pro Phe Gln Gln Ile
465 470 475 480
Tyr Gly Lys Arg Met Gly Gly Leu Leu Phe Ile Pro Ala Leu Met Gly
485 490 495
Glu Met Phe Trp Ala Ala Ala Ile Phe Ser Ala Leu Gly Ala Thr Ile
500 505 510
Ser Val Ile Ile Asp Val Asp Met His Ile Ser Val Ile Ile Ser Ala
515 520 525
Leu Ile Ala Thr Leu Tyr Thr Leu Val Gly Gly Leu Tyr Ser Val Ala
530 535 540
Tyr Thr Asp Val Val Gln Leu Phe Cys Ile Phe Val Gly Leu Trp Ile
545 550 555 560
Ser Val Pro Phe Ala Leu Ser His Pro Ala Val Ala Asp Ile Gly Phe
565 570 575
Thr Ala Val His Ala Lys Tyr Gln Lys Pro Trp Leu Gly Thr Val Asp
580 585 590
Ser Ser Glu Val Tyr Ser Trp Leu Asp Ser Phe Leu Leu Leu Met Leu
595 600 605
Gly Gly Ile Pro Trp Gln Ala Tyr Phe Gln Arg Val Leu Ser Ser Ser
610 615 620
Ser Ala Thr Tyr Ala Gln Val Leu Ser Phe Leu Ala Ala Phe Gly Cys
625 630 635 640
Leu Val Met Ala Ile Pro Ala Ile Leu Ile Gly Ala Ile Gly Ala Ser
645 650 655
Thr Asp Trp Asn Gln Thr Ala Tyr Gly Leu Pro Asp Pro Lys Thr Thr
660 665 670
Glu Glu Ala Asp Met Ile Leu Pro Ile Val Leu Gln Tyr Leu Cys Pro
675 680 685
Val Tyr Ile Ser Phe Phe Gly Leu Gly Ala Val Ser Ala Ala Val Met
690 695 700
Ser Ser Ala Asp Ser Ser Ile Leu Ser Ala Ser Ser Met Phe Ala Arg
705 710 715 720
Asn Ile Tyr Gln Leu Ser Phe Arg Gln Asn Ala Ser Asp Lys Glu Ile
725 730 735
Val Trp Val Met Arg Ile Thr Val Phe Val Phe Gly Ala Ser Ala Thr
740 745 750
Ala Met Ala Leu Leu Thr Lys Thr Val Tyr Gly Leu Trp Tyr Leu Ser
755 760 765
Ser Asp Leu Val Tyr Ile Val Ile Phe Pro Gln Leu Leu Cys Val Leu
770 775 780
Phe Val Lys Gly Thr Asn Thr Tyr Gly Ala Val Ala Gly Tyr Val Ser
785 790 795 800
Gly Leu Phe Leu Arg Ile Thr Gly Gly Glu Pro Tyr Leu Tyr Leu Gln
805 810 815
Pro Leu Ile Phe Tyr Pro Gly Tyr Tyr Pro Asp Asp Asn Gly Ile Tyr
820 825 830
Asn Gln Lys Phe Pro Phe Lys Thr Leu Ala Met Val Thr Ser Phe Leu
835 840 845
Thr Asn Ile Cys Ile Ser Tyr Leu Ala Lys Tyr Leu Phe Glu Ser Gly
850 855 860
Thr Leu Pro Pro Lys Leu Asp Val Phe Asp Ala Val Val Ala Arg His
865 870 875 880
Ser Glu Glu Asn Met Asp Lys Thr Ile Leu Val Lys Asn Glu Asn Ile
885 890 895
Lys Leu Asp Glu Leu Ala Leu Val Lys Pro Arg Gln Ser Met Thr Leu
900 905 910
Ser Ser Thr Phe Thr Asn Lys Glu Ala Phe Leu Asp Val Asp Ser Ser
915 920 925
Pro Glu Gly Ser Gly Thr Glu Asp Asn Leu Gln
930 935
<210> 27
<211> 2198
<212> DNA
<213> artificial
<220>
<223> tTA-SNAP25-GST(pCMV-Tet3G)
<400> 27
gaattcacca tgtctagact ggacaagagc aaagtcataa actctgctct ggaattactc 60
aatggagtcg gtatcgaagg cctgacgaca aggaaactcg ctcaaaagct gggagttgag 120
cagcctaccc tgtactggca cgtgaagaac aagcgggccc tgctcgatgc cctgccaatc 180
gagatgctgg acaggcatca tacccactcc tgccccctgg aaggcgagtc atggcaagac 240
tttctgcgga acaacgccaa gtcataccgc tgtgctctcc tctcacatcg cgacggggct 300
aaagtgcatc tcggcacccg cccaacagag aaacagtacg aaaccctgga aaatcagctc 360
gcgttcctgt gtcagcaagg cttctccctg gagaacgcac tgtacgctct gtccgccgtg 420
ggccacttta cactgggctg cgtattggag gaacaggagc atcaagtagc aaaagaggaa 480
agagagacac ctaccaccga ttctatgccc ccacttctga aacaagcaat tgagctgttc 540
gaccggcagg gagccgaacc tgccttcctt ttcggcctgg aactaatcat atgtggcctg 600
gagaaacagc taaagtgcga aagcggcggg ccgaccgacg cccttgacga ttttgactta 660
gacatgctcc cagccgatgc ccttgacgac tttgaccttg atatgctgcc tgctgacgct 720
cttgacgatt ttgaccttga catgctcccc ggggccggcg ccggcagcgg agtggtggcc 780
agccagcctg ctcgtgtagt ggacgaacgg gagcagatgg ccatcagtgg cggcttcatc 840
cgcagggtaa caaatgatgc ccgagaaaat gaaatggatg aaaacctaga gcaggtgagc 900
ggcatcatcg ggaacctccg tcacatggcc ctggatatgg gcaatgagat cgatacacag 960
aatcgccaga tcgacaggat catggagaag gctgattcca acaaaaccag aattgatgag 1020
gccaaccaac gtgcaacaaa gatgctggga agtggttccc ctatactagg ttattggaaa 1080
attaagggcc ttgtgcaacc cactcgactt cttttggaat atcttgaaga aaaatatgaa 1140
gagcatttgt atgagcgcga tgaaggtgat aaatggcgaa acaaaaagtt tgaattgggt 1200
ttggagtttc ccaatcttcc ttattatatt gatggtgatg ttaaattaac acagtctatg 1260
gccatcatac gttatatagc tgacaagcac aacatgttgg gtggttgtcc aaaagagcgt 1320
gcagagattt caatgcttga aggagcggtt ttggatatta gatacggtgt ttcgagaatt 1380
gcatatagta aagactttga aactctcaaa gttgattttc ttagcaagct acctgaaatg 1440
ctgaaaatgt tcgaagatcg tttatgtcat aaaacatatt taaatggtga tcatgtaacc 1500
catcctgact tcatgttgta tgacgctctt gatgttgttt tatacatgga cccaatgtgc 1560
ctggatgcgt tcccaaaatt agtttgtttt aaaaaacgta ttgaagctat cccacaaatt 1620
gataagtact tgaaatccag caagtatata gcatggcctt tgcagggctg gcaagccacg 1680
tttggtggtg gcgaccatcc tccaaaatcg gattaactaa gtaaggatcc agacatgata 1740
agatacattg atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt 1800
tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt 1860
aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt 1920
taaagcaagt aaaacctcta caaatgtggt atggctgatt atgatcctgc aagcctcgtc 1980
gtcctggccg gaccacgcta tctgtgcaag gtccccggcc ccggacgcgc gctccatgag 2040
cagagcgccc gccgccgagg cgaagactcg ggcggcgccc tgcccgtccc accaggtcaa 2100
caggcggtaa ccggcctctt catcgggaat gcgcgcgacc ttcagcatcg ccggcatgtc 2160
cccctggcgg acgggaagta tccagctcga ccaagctt 2198
<210> 28
<211> 569
<212> PRT
<213> artificial
<220>
<223> tTA-SNAP25-GST(pCMV-Tet3G)
<400> 28
Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu
1 5 10 15
Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln
20 25 30
Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys
35 40 45
Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His
50 55 60
Thr His Ser Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg
65 70 75 80
Asn Asn Ala Lys Ser Tyr Arg Cys Ala Leu Leu Ser His Arg Asp Gly
85 90 95
Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr
100 105 110
Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu
115 120 125
Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys
130 135 140
Val Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr
145 150 155 160
Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Lys Gln Ala Ile Glu Leu
165 170 175
Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu
180 185 190
Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro
195 200 205
Thr Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala
210 215 220
Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp
225 230 235 240
Phe Asp Leu Asp Met Leu Pro Gly Ala Gly Ala Gly Ser Gly Val Val
245 250 255
Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala Ile
260 265 270
Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn Glu
275 280 285
Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu Arg
290 295 300
His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln
305 310 315 320
Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile Asp
325 330 335
Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly Met Ser Pro
340 345 350
Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro Thr Arg Leu
355 360 365
Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu Tyr Glu Arg
370 375 380
Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu Gly Leu Glu
385 390 395 400
Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys Leu Thr Gln
405 410 415
Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn Met Leu Gly
420 425 430
Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu Gly Ala Val
435 440 445
Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser Lys Asp Phe
450 455 460
Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu Met Leu Lys
465 470 475 480
Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn Gly Asp His
485 490 495
Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp Val Val Leu
500 505 510
Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu Val Cys Phe
515 520 525
Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr Leu Lys Ser
530 535 540
Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala Thr Phe Gly
545 550 555 560
Gly Gly Asp His Pro Pro Lys Ser Asp
565
<210> 29
<211> 2255
<212> DNA
<213> artificial
<220>
<223> tTA-SNAP25-GFP(pCMV-Tet3G)
<400> 29
gaattcacca tgtctagact ggacaagagc aaagtcataa actctgctct ggaattactc 60
aatggagtcg gtatcgaagg cctgacgaca aggaaactcg ctcaaaagct gggagttgag 120
cagcctaccc tgtactggca cgtgaagaac aagcgggccc tgctcgatgc cctgccaatc 180
gagatgctgg acaggcatca tacccactcc tgccccctgg aaggcgagtc atggcaagac 240
tttctgcgga acaacgccaa gtcataccgc tgtgctctcc tctcacatcg cgacggggct 300
aaagtgcatc tcggcacccg cccaacagag aaacagtacg aaaccctgga aaatcagctc 360
gcgttcctgt gtcagcaagg cttctccctg gagaacgcac tgtacgctct gtccgccgtg 420
ggccacttta cactgggctg cgtattggag gaacaggagc atcaagtagc aaaagaggaa 480
agagagacac ctaccaccga ttctatgccc ccacttctga aacaagcaat tgagctgttc 540
gaccggcagg gagccgaacc tgccttcctt ttcggcctgg aactaatcat atgtggcctg 600
gagaaacagc taaagtgcga aagcggcggg ccgaccgacg cccttgacga ttttgactta 660
gacatgctcc cagccgatgc ccttgacgac tttgaccttg atatgctgcc tgctgacgct 720
cttgacgatt ttgaccttga catgctcccc ggggccggcg ccggcagcgg agtggtggcc 780
agccagcctg ctcgtgtagt ggacgaacgg gagcagatgg ccatcagtgg cggcttcatc 840
cgcagggtaa caaatgatgc ccgagaaaat gaaatggatg aaaacctaga gcaggtgagc 900
ggcatcatcg ggaacctccg tcacatggcc ctggatatgg gcaatgagat cgatacacag 960
aatcgccaga tcgacaggat catggagaag gctgattcca acaaaaccag aattgatgag 1020
gccaaccaac gtgcaacaaa gatgctggga agtggtgcca gcaaaggaga agaacttttc 1080
actggagttg tcccaattct tgttgaatta gatggtgatg ttaatgggca caaattttct 1140
gtcagtggag agggtgaagg tgatgctaca tacggaaagc ttacccttaa atttatttgc 1200
actactggaa aactacctgt tccatggcca acacttgtca ctactttctc ttatggtgtt 1260
caatgctttt cccgttatcc ggatcatatg aaacggcatg actttttcaa gagtgccatg 1320
cccgaaggtt atgtacagga acgcactata tctttcaaag atgacgggaa ctacaagacg 1380
cgtgctgaag tcaagtttga aggtgatacc cttgttaatc gtatcgagtt aaaaggtatt 1440
gattttaaag aagatggaaa cattctcgga cacaaactcg agtacaacta taactcacac 1500
aatgtataca tcacggcaga caaacaaaag aatggaatca aagctaactt caaaattcgc 1560
cacaacattg aagatggatc cgttcaacta gcagaccatt atcaacaaaa tactccaatt 1620
ggcgatggcc ctgtcctttt accagacaac cattacctgt cgacacaatc tgccctttcg 1680
aaagatccca acgaaaagcg tgaccacatg gtccttcttg agtttgtaac tgctgctggg 1740
attacacatg gcatggatga gctctacaaa taactaagta aggatccaga catgataaga 1800
tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt 1860
gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa acaagttaac 1920
aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa 1980
agcaagtaaa acctctacaa atgtggtatg gctgattatg atcctgcaag cctcgtcgtc 2040
ctggccggac cacgctatct gtgcaaggtc cccggccccg gacgcgcgct ccatgagcag 2100
agcgcccgcc gccgaggcga agactcgggc ggcgccctgc ccgtcccacc aggtcaacag 2160
gcggtaaccg gcctcttcat cgggaatgcg cgcgaccttc agcatcgccg gcatgtcccc 2220
ctggcggacg ggaagtatcc agctcgacca agctt 2255
<210> 30
<211> 696
<212> PRT
<213> artificial
<220>
<223> tTA-SNAP25-GFP(pCMV-Tet3G)
<400> 30
Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu
1 5 10 15
Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln
20 25 30
Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys
35 40 45
Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His
50 55 60
Thr His Ser Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg
65 70 75 80
Asn Asn Ala Lys Ser Tyr Arg Cys Ala Leu Leu Ser His Arg Asp Gly
85 90 95
Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr
100 105 110
Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu
115 120 125
Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys
130 135 140
Val Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr
145 150 155 160
Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Lys Gln Ala Ile Glu Leu
165 170 175
Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu
180 185 190
Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro
195 200 205
Thr Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala
210 215 220
Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp
225 230 235 240
Phe Asp Leu Asp Met Leu Pro Gly Ala Gly Ala Gly Ser Gly Val Val
245 250 255
Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala Ile
260 265 270
Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn Glu
275 280 285
Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu Arg
290 295 300
His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln
305 310 315 320
Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile Asp
325 330 335
Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly Ala Ser Lys
340 345 350
Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp
355 360 365
Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly
370 375 380
Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly
385 390 395 400
Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Ser Tyr Gly
405 410 415
Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg His Asp Phe
420 425 430
Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser
435 440 445
Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu
450 455 460
Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys
465 470 475 480
Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser
485 490 495
His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala
500 505 510
Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala
515 520 525
Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu
530 535 540
Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro
545 550 555 560
Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala
565 570 575
Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Ala Glu Asp Ala Asp
580 585 590
Met Arg Asn Glu Leu Glu Glu Met Gln Arg Arg Ala Asp Gln Leu Ala
595 600 605
Asp Glu Ser Leu Glu Ser Thr Arg Arg Met Leu Gln Leu Val Glu Glu
610 615 620
Ser Lys Asp Ala Gly Ile Arg Thr Leu Val Met Leu Asp Glu Gln Gly
625 630 635 640
Glu Gln Leu Glu Arg Ile Glu Glu Gly Met Asp Gln Ile Asn Lys Asp
645 650 655
Met Lys Glu Ala Glu Lys Asn Leu Thr Asp Leu Gly Lys Phe Cys Gly
660 665 670
Leu Cys Val Cys Pro Cys Asn Lys Leu Lys Ser Ser Asp Ala Tyr Lys
675 680 685
Lys Ala Trp Gly Asn Asn Gln Asp
690 695
<210> 31
<211> 444
<212> PRT
<213> artificial
<220>
<223> SNAP110-pTET-tTAK
<400> 31
Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val
1 5 10 15
Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala
20 25 30
Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn
35 40 45
Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu
50 55 60
Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg
65 70 75 80
Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile
85 90 95
Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly Ser Arg
100 105 110
Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Glu
115 120 125
Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly
130 135 140
Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu
145 150 155 160
Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His Thr His Phe
165 170 175
Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala
180 185 190
Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val
195 200 205
His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn
210 215 220
Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu
225 230 235 240
Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu
245 250 255
Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr
260 265 270
Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp His
275 280 285
Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys
290 295 300
Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser Ala Tyr Ser Arg
305 310 315 320
Ala Arg Thr Lys Asn Asn Tyr Gly Ser Thr Ile Glu Gly Leu Leu Asp
325 330 335
Leu Pro Asp Asp Asp Ala Pro Glu Glu Ala Gly Leu Ala Ala Pro Arg
340 345 350
Leu Ser Phe Leu Pro Ala Gly His Thr Arg Arg Leu Ser Thr Ala Pro
355 360 365
Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly Glu Asp
370 375 380
Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met
385 390 395 400
Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His Asp Ser
405 410 415
Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu Gln Met
420 425 430
Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly
435 440
<210> 32
<211> 10
<212> PRT
<213> artificial
<220>
<223> leucine-rich nuclear export signal (NES)
<220>
<221> misc_feature
<222> (2)..(4)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (6)..(7)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (9)..(9)
<223> Xaa can be any naturally occurring amino acid
<400> 32
Leu Xaa Xaa Xaa Leu Xaa Xaa Leu Xaa Leu
1 5 10
<210> 33
<211> 247
<212> PRT
<213> artificial
<220>
<223> tetracycline dependent transactivator
<400> 33
Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu
1 5 10 15
Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys
20 25 30
Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg
35 40 45
Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His Thr
50 55 60
His Ser Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn
65 70 75 80
Asn Ala Lys Ser Tyr Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala
85 90 95
Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu
100 105 110
Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn
115 120 125
Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val
130 135 140
Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro
145 150 155 160
Thr Thr Asp Ser Met Pro Pro Leu Leu Lys Gln Ala Ile Glu Leu Phe
165 170 175
Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile
180 185 190
Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Thr
195 200 205
Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu
210 215 220
Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe
225 230 235 240
Asp Leu Asp Met Leu Pro Gly
245
<210> 34
<211> 334
<212> PRT
<213> artificial
<220>
<223> tetracycline dependent transactivator
<400> 34
Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu
1 5 10 15
Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys
20 25 30
Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg
35 40 45
Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His Thr
50 55 60
His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn
65 70 75 80
Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala
85 90 95
Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu
100 105 110
Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn
115 120 125
Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val
130 135 140
Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro
145 150 155 160
Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe
165 170 175
Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile
180 185 190
Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser Ala Tyr
195 200 205
Ser Arg Ala Arg Thr Lys Asn Asn Tyr Gly Ser Thr Ile Glu Gly Leu
210 215 220
Leu Asp Leu Pro Asp Asp Asp Ala Pro Glu Glu Ala Gly Leu Ala Ala
225 230 235 240
Pro Arg Leu Ser Phe Leu Pro Ala Gly His Thr Arg Arg Leu Ser Thr
245 250 255
Ala Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly
260 265 270
Glu Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu
275 280 285
Asp Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His
290 295 300
Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu
305 310 315 320
Gln Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly
325 330
<210> 35
<211> 22
<212> DNA
<213> artificial
<220>
<223> forward primer Tet-element
<400> 35
agctgggagt tgagcagcct ac 22
<210> 36
<211> 22
<212> DNA
<213> artificial
<220>
<223> reverse primer Tet-element
<400> 36
ggtgccgaga tgcactttag cc 22
<210> 37
<211> 20
<212> DNA
<213> artificial
<220>
<223> forward primer Luciferase
<400> 37
gaagagatac gccctggttc 20
<210> 38
<211> 20
<212> DNA
<213> artificial
<220>
<223> reverse primer Luciferase
<400> 38
cgggaggtag atgagatgtg 20
Claims (17)
- 신경독소 절단 부위를 포함하는 링커로 분리된, (ⅰ) 전사인자 도메인 및 (ⅱ) 세포질 유지 도메인을 포함하는 융합 폴리펩티드를 코딩하는 폴리뉴클레오티드.
- 청구항 1에 있어서,
상기 세포질 유지 도메인은 막관통 단백질 또는 막관통 단백질의 막관통 스패닝 도메인인 폴리뉴클레오티드. - 청구항 2에 있어서,
상기 막관통 단백질은 혈장막 신경전달물질 트랜스포터, 이온 채널, G-단백질 결합 수용체 및 막 수용체로 이루어진 군으로부터 선택되는 폴리뉴클레오티드. - 청구항 1에 있어서,
상기 세포질 유지 도메인은 막고정 단백질 또는 막고정 단백질의 막고정 도메인인 폴리뉴클레오티드. - 청구항 4에 있어서,
상기 막고정 단백질은 SNAP-25, 신탁신, 시냅토브레빈, 시냅토타그민, 소포 연관 막 단백질 (VAMPs), 시냅스 소포 당단백질 (SV2), 고 친화성 콜린 트랜스포터, 뉴렉신, 전압 개폐 칼슘 채널, 아세틸콜린에스테라아제 및 NOTCH로 이루어진 군으로부터 선택되는 폴리뉴클레오티드. - 청구항 1에 있어서,
상기 세포질 유지 도메인은 구상 단백질 및 세포골격 고정 단백질로 이루어진 군으로부터 선택되는 폴리뉴클레오티드. - 청구항 1 내지 6 중 어느 한 항에 있어서,
상기 전사인자 도메인은 DNA 결합 도메인을 포함하는 전사인자 및 트랜스활성인자 또는 사일렌서 도메인을 포함하는 폴리뉴클레오티드. - 청구항 7에 있어서,
상기 전사인자는 테트라사이클린 의존성 트랜스활성인자 (tet-억제인자-VP 16), 스테로이드 호르몬 수용체, NOTCH, NFkB, p53, NFAT, MLL, E2A, HSF1, NF-IL6, STAT, R-SMAD, GAL4, 및 SP1로 이루어진 군으로부터 선택되는 폴리뉴클레오티드. - 청구항 1 내지 8 중 어느 한 항의 폴리뉴클레오티드를 포함하는 벡터.
- 청구항 1 내지 8 중 어느 한 항의 폴리뉴클레오티드에 의해 코딩되는 융합 폴리펩티드.
- 청구항 1 내지 8 중 어느 한 항의 폴리뉴클레오티드, 청구항 9의 벡터 또는 청구항 10의 융합 폴리펩티드를 포함하는 숙주 세포.
- 청구항 11에 있어서,
상기 숙주 세포는 일차 신경 세포, 신경아세포종 세포주, N1E-115 세포주, Neuro2a 세포주, SH-SY5Y 세포주, PC12 세포주, SiMa 세포주, MHH-NB-11 세포주, SK-N-BE(2) 세포주 및 유도 만능줄기세포로 이루어진 군으로부터 선택되는 숙주 세포. - 청구항 11 또는 12에 있어서,
상기 숙주 세포는 상기 융합 폴리펩티드의 절단에 따라 그 발현이 전사인자 도메인에 의하여 조절되는 리포터 유전자를 포함하는 숙주 세포. - 하기 단계:
(a) 청구항 10의 융합 폴리펩티드를 포함하는 숙주 세포 및 상기 융합 폴리펩티드의 절단에 따라 그 발현이 상기 전사인자 도메인에 의하여 조절되는 리포터 유전자를 신경독소 활성을 포함하는 것으로 예상되는 샘플에 접촉시키는 단계; 및
(b) 상기 리포터 유전자 활성을 측정하는 단계;를 포함하며,
상기 측정에 의하여 상기 샘플 내의 신경독소 활성이 결정되는 샘플 내의 신경독소 활성을 결정하기 위한 방법. - 청구항 14에 있어서,
상기 숙주 세포는 청구항 11 내지 13 중 어느 한 항의 숙주 세포인 샘플 내의 신경독소 활성을 결정하기 위한 방법. - 샘플 내의 신경독소 활성을 결정하기 위한 청구항 1 내지 8 중 어느 한 항의 폴리뉴클레오티드, 청구항 9의 벡터, 청구항 10의 융합 폴리펩티드 또는 청구항 11 또는 13의 숙주 세포의 용도.
- 청구항 1 내지 8 중 어느 한 항의 폴리뉴클레오티드, 청구항 9의 벡터, 청구항 10의 융합 폴리펩티드 또는 청구항 11 또는 13의 숙주 세포 및 바람직하게는, 리포터 유전자 활성을 검출하기 위한 검출 제제를 포함하는 신경독소 활성을 결정하기 위한 키트.
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KR20190068582A (ko) * | 2016-10-20 | 2019-06-18 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 보툴리눔 신경독소의 활성을 측정하기 위한 시험관내 및 세포 기반 검정 |
WO2020060128A1 (ko) * | 2018-09-21 | 2020-03-26 | 아이큐어 주식회사 | 세포 침투 효과가 우수한 보툴리늄 유래 펩타이드를 포함하는 화장료 조성물 |
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Cited By (3)
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WO2017204561A3 (ko) * | 2016-05-24 | 2018-01-18 | (주)메디톡스 | 리포터 모이어티, 기질 모이어티 및 탈안정화 모이어티를 포함하는 폴리펩티드를 코딩하는 재조합 폴리뉴클레오티드, 그를 포함하는 숙주세포, 및 그의 용도 |
KR20190068582A (ko) * | 2016-10-20 | 2019-06-18 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 보툴리눔 신경독소의 활성을 측정하기 위한 시험관내 및 세포 기반 검정 |
WO2020060128A1 (ko) * | 2018-09-21 | 2020-03-26 | 아이큐어 주식회사 | 세포 침투 효과가 우수한 보툴리늄 유래 펩타이드를 포함하는 화장료 조성물 |
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HK1210190A1 (en) | 2016-04-15 |
AU2013349725B2 (en) | 2016-05-12 |
JP2016502405A (ja) | 2016-01-28 |
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US20160289731A1 (en) | 2016-10-06 |
EP2922866B1 (en) | 2019-01-23 |
WO2014079878A1 (en) | 2014-05-30 |
EP2922866A1 (en) | 2015-09-30 |
IL237620A0 (en) | 2015-04-30 |
BR112015011255A2 (pt) | 2018-09-25 |
AU2013349725A1 (en) | 2015-04-30 |
MX2015006301A (es) | 2015-09-07 |
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CA2885294A1 (en) | 2014-05-30 |
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