LT3014267T - Priemonės ir būdai, skirti neurotoksinių polipeptidų nustatymui - Google Patents
Priemonės ir būdai, skirti neurotoksinių polipeptidų nustatymuiInfo
- Publication number
- LT3014267T LT3014267T LTEP14733620.0T LT14733620T LT3014267T LT 3014267 T LT3014267 T LT 3014267T LT 14733620 T LT14733620 T LT 14733620T LT 3014267 T LT3014267 T LT 3014267T
- Authority
- LT
- Lithuania
- Prior art keywords
- cells
- determination
- methods
- biological activity
- neurotoxin polypeptides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/952—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Developmental Biology & Embryology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13174176 | 2013-06-28 | ||
| PCT/EP2014/063531 WO2014207109A1 (en) | 2013-06-28 | 2014-06-26 | Means and methods for the determination of the biological activity of neurotoxin polypeptides in cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3014267T true LT3014267T (lt) | 2018-12-10 |
Family
ID=48692360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP14733620.0T LT3014267T (lt) | 2013-06-28 | 2014-06-26 | Priemonės ir būdai, skirti neurotoksinių polipeptidų nustatymui |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US11976110B2 (lt) |
| EP (1) | EP3014267B1 (lt) |
| JP (1) | JP6608357B2 (lt) |
| KR (1) | KR102266362B1 (lt) |
| CN (1) | CN105339790B (lt) |
| AU (1) | AU2014301116B2 (lt) |
| CA (1) | CA2913686C (lt) |
| ES (1) | ES2699432T3 (lt) |
| HK (1) | HK1215299A1 (lt) |
| HR (1) | HRP20181989T1 (lt) |
| IL (1) | IL243157B (lt) |
| LT (1) | LT3014267T (lt) |
| MX (1) | MX360513B (lt) |
| PL (1) | PL3014267T3 (lt) |
| RU (1) | RU2704808C2 (lt) |
| SG (1) | SG11201510685UA (lt) |
| SI (1) | SI3014267T1 (lt) |
| TW (1) | TWI632369B (lt) |
| WO (1) | WO2014207109A1 (lt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6772138B2 (ja) | 2014-12-19 | 2020-10-21 | メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー | 細胞内のＢｏＮＴ／Ｅの生物学的活性を決定するための手段及び方法 |
| KR102557798B1 (ko) | 2014-12-23 | 2023-07-19 | 메르츠 파마 게엠베하 운트 코. 카가아 | 보툴리눔 독소 사전충전된 용기 |
| TWI704156B (zh) * | 2015-03-04 | 2020-09-11 | 德商曼茲法瑪股份有限公司 | 用於增進肉毒桿菌神經毒素進入細胞之特定攝取的方法 |
| WO2017063743A1 (en) | 2015-10-14 | 2017-04-20 | Merz Pharma Gmbh & Co. Kgaa | Improvements to ultrasound-based therapy of photoaged tissue |
| US11969461B2 (en) | 2016-03-02 | 2024-04-30 | Merz Pharma Gmbh & Co. Kgaa | Composition comprising botulinum toxin |
| TWI737742B (zh) | 2016-06-22 | 2021-09-01 | 德商梅茲製藥有限兩合公司 | 肉毒桿菌毒素的預填充式注射器系統、具有其之套組以及其之使用 |
| EP3290437A1 (en) | 2016-08-31 | 2018-03-07 | Merz Pharma GmbH & Co. KGaA | Novel recombinant clostridial neurotoxins with decreased duration of effect |
| EP3312193A1 (en) | 2016-10-19 | 2018-04-25 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum neurotoxins with accelerated onset of effect |
| SG11201903523YA (en) * | 2016-10-20 | 2019-05-30 | Harvard College | In vitro and cell based assays for measuring the activity of botulinum neurotoxins |
| EP3333179A1 (en) | 2016-12-07 | 2018-06-13 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum toxin with accelarated onset of effect |
| EP3335719A1 (en) | 2016-12-14 | 2018-06-20 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum neurotoxins with a stabilized light chain |
| MX2019009860A (es) | 2017-03-24 | 2019-10-15 | Merz Pharma Gmbh & Co Kgaa | Uso mejorado de neurotoxina botulinica en el tratamiento de sialorrea. |
| EP3630298A1 (en) * | 2017-05-31 | 2020-04-08 | Allergan, Inc. | Botulinum neurotoxin for treatment of disorders associated with melanocyte hyperactivity and/or excess melanin |
| EP3642222A1 (en) | 2017-06-20 | 2020-04-29 | Merz Pharma GmbH & Co. KGaA | Novel recombinant botulinum toxin with increased duration of effect |
| ES2930237T3 (es) | 2017-07-06 | 2022-12-09 | Merz Pharma Gmbh & Co Kgaa | Neurotoxinas botulínicas recombinantes nuevas con mayor duración de efectos |
| WO2019081022A1 (en) | 2017-10-26 | 2019-05-02 | Merz Pharma Gmbh & Co. Kgaa | NOVEL RECOMBINANT BOTULINUM NEUROTOXINS WITH INCREASED DURATION |
| US20200354706A1 (en) | 2017-11-22 | 2020-11-12 | Merz Pharma Gmbh & Co. Kgaa | Novel recombinant botulinum toxin with increased duration of effect |
| EP3860640A1 (en) | 2018-10-02 | 2021-08-11 | Merz Pharma GmbH & Co. KGaA | Novel uses of botulinum neurotoxin for treating lipoedema |
| US20210338528A1 (en) | 2018-10-08 | 2021-11-04 | Merz Pharma Gmbh & Co. Kgaa | Neurotoxin prefilled vial |
| EP3825689A3 (en) | 2018-11-29 | 2021-09-15 | Hugel Inc. | A cell-based method for determining an activity of botulinum toxin |
| JP2022521237A (ja) | 2019-02-21 | 2022-04-06 | メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン | 振戦治療のためのボツリヌス神経毒素の新規用途 |
| IL298399A (en) | 2020-06-05 | 2023-01-01 | Merz Pharma Gmbh & Co Kgaa | Treatment of facial wrinkles with the botulinum toxin in high dose and low volume |
| CN111621525B (zh) * | 2020-06-18 | 2021-04-23 | 中赛干细胞基因工程有限公司 | Stx1b基因在促进人脂肪间充质干细胞生长和分化中的用途 |
| US20220010355A1 (en) * | 2020-07-10 | 2022-01-13 | Galderma Holding SA | Cell based method for determination of botulinum toxin potency based on western blotting |
| WO2023156385A1 (en) | 2022-02-15 | 2023-08-24 | Merz Pharma Gmbh & Co. Kgaa | Liquid botulinum toxin formulation and use thereof |
| TW202348248A (zh) | 2022-02-15 | 2023-12-16 | 德商梅茲製藥有限兩合公司 | 液體製劑及其製備方法與用途 |
| TW202400122A (zh) | 2022-02-28 | 2024-01-01 | 德商梅茲製藥有限兩合公司 | 肉毒桿菌毒素用於降低皮膚毛孔尺寸及／或皮脂產生之用途、以及降低皮膚毛孔尺寸及／或皮脂產生的方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9411138D0 (en) | 1994-06-03 | 1994-07-27 | Microbiological Res Authority | Toxin assay |
| CA2380457A1 (en) | 1999-08-25 | 2001-03-01 | Allergan Sales, Inc. | Activatable recombinant neurotoxins |
| US20080032931A1 (en) | 1999-08-25 | 2008-02-07 | Steward Lance E | Activatable clostridial toxins |
| US7115399B2 (en) | 2001-07-31 | 2006-10-03 | Allergan, Inc. | Pinna reflex assay |
| US6984375B2 (en) | 2001-08-03 | 2006-01-10 | Allergan, Inc. | Nuclei density and nuclei area methods for determining effects of a botulinum toxin on muscles |
| US7332567B2 (en) | 2001-08-28 | 2008-02-19 | Allergan, Inc. | Fret protease assays for clostridial toxins |
| GB2398636A (en) | 2003-02-21 | 2004-08-25 | Ipsen Ltd | Method for determining the quantity of pre-synaptic neuromuscular blocking substance contained in a sample |
| DE10333317A1 (de) | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| RU2265057C2 (ru) * | 2003-11-20 | 2005-11-27 | Научно-исследовательский институт микробиологии Министерства обороны Российской Федерации | Способ индикации биоцидной активности перекисных дезинфицирующих растворов к ботулиническому нейротоксину |
| JP5178009B2 (ja) | 2003-12-19 | 2013-04-10 | ウィスコンシン アルムニ リサーチ ファンデイション | ボツリヌス神経毒素検出のための方法および複合体 |
| EP2266600B1 (en) | 2004-07-26 | 2014-09-10 | Merz Pharma GmbH & Co. KGaA | Therapeutic composition with a botulinum neurotoxin |
| GB2416849A (en) | 2004-08-04 | 2006-02-08 | Ipsen Ltd | Method for determining the quantity of a pre-synaptic neuromuscular blocking substance in a sample |
| DK2154151T3 (da) | 2005-09-19 | 2011-09-05 | Allergan Inc | Clostridiumtoksinaktiverbare clostridiumtoksiner |
| WO2007125604A1 (ja) | 2006-04-28 | 2007-11-08 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | 神経毒素の定量方法 |
| FI20070808A0 (fi) | 2007-10-25 | 2007-10-25 | Mart Saarma | GDNF:n silmukointivariantit ja niiden käytöt |
| EP2235161A1 (en) | 2007-12-11 | 2010-10-06 | Research Development Foundation | Small molecules for neuronal differentiation of embryonic stem cells |
| WO2009098698A2 (en) | 2008-02-07 | 2009-08-13 | Shahar Cohen | Compartmental extract compositions for tissue engineering |
| EP3556770A1 (en) * | 2008-03-14 | 2019-10-23 | Allergan, Inc. | Immuno-based botulinum toxin serotype a activity assays |
| US8669048B2 (en) | 2008-06-24 | 2014-03-11 | Parkinson's Institute | Pluripotent cell lines and methods of use thereof |
| CA2753208C (en) | 2009-02-20 | 2018-08-21 | Cellular Dynamics International, Inc. | Methods and compositions for the differentiation of stem cells |
| CA2753679C (en) | 2009-02-27 | 2021-03-02 | Cellular Dynamics International, Inc. | Differentiation of pluripotent cells |
| JP5717657B2 (ja) | 2009-03-13 | 2015-05-13 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 免疫系ボツリヌス毒素血清型ａ活性アッセイに有用な細胞 |
| ES2647243T3 (es) * | 2009-04-27 | 2017-12-20 | Merz Pharma Gmbh & Co. Kgaa | Medios y métodos para la determinación de la cantidad de polipéptido Neurotoxina y de sus actividades catalíticas y proteolíticas |
| WO2011022438A2 (en) * | 2009-08-18 | 2011-02-24 | Us Army Medical Research And Materiel Command | Cleavage sensitive antibodies and methods of use thereof |
| WO2011031568A2 (en) | 2009-08-27 | 2011-03-17 | Synaptic Research, Llc | A NOVEL PROTEIN DELIVERY SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM (iPS) CELLS OR TISSUE-SPECIFIC CELLS |
| US9506114B2 (en) | 2009-08-28 | 2016-11-29 | Cellular Dynamics International, Inc. | Identifying genetic variation in affected tissues |
| EP3067696B1 (en) * | 2009-10-16 | 2018-06-06 | BioMadison, Inc. | Genetically modified cells for resonance energy transfer assay with synaptobrevin substrate moiety |
| KR101775926B1 (ko) | 2009-11-04 | 2017-09-07 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 화학 물질을 이용한 에피솜 재프로그래밍 |
| BR112012011675A2 (pt) | 2009-11-18 | 2016-07-05 | Merz Pharma Gmbh & Co Kgaa | método de medição de um efeito induzido a um tecido celular e a um tecido muscular por uma neurotoxina clostridial, seu uso e produto de programa de computador |
| WO2012123370A1 (en) | 2011-03-11 | 2012-09-20 | Merz Pharma Gmbh & Co. Kgaa | Method for the determination of botulinum neurotoxin biological activity |
| US9487752B2 (en) | 2011-03-30 | 2016-11-08 | Cellular Dynamics International, Inc. | Priming of pluripotent stem cells for neural differentiation |
| US9217172B2 (en) * | 2011-09-29 | 2015-12-22 | Cellsnap, Llc | Compositions and methods for toxigenicity testing |
| US10451621B2 (en) | 2011-12-31 | 2019-10-22 | Allergan, Inc. | Highly sensitive cell-based assay to detect the presence of active botulinum neurotoxin serotype-A |
| JP2015509372A (ja) | 2012-03-07 | 2015-03-30 | メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー | 修飾ルシフェラーゼに基づいて神経毒活性を測定するための手段および方法 |
| US8778623B2 (en) | 2012-09-14 | 2014-07-15 | Wisconsin Alumni Research Foundation | Compositions and methods of using differentiated cells sensitized to botulinum neurotoxin |
| US20160289731A1 (en) | 2012-11-21 | 2016-10-06 | Merz Pharma Gmbh & Co, Kgaa | Means and methods for determination of botulinum neurotoxin biological activity |
| US9102901B2 (en) | 2012-12-20 | 2015-08-11 | Rohm And Haas Electronic Materials Llc | Methods and compositions for removal of metal hardmasks |
| US10921312B2 (en) | 2014-02-19 | 2021-02-16 | Merz Pharma Gmbh & Co. Kgaa | Gangliosides for standardizing and increasing the sensitivity of cells to botulinum neurotoxins in in vitro test systems |
| CN107003310B (zh) | 2014-11-21 | 2019-07-19 | 莫茨药物股份两合公司 | 用于测定神经毒素多肽的生物活性的方法 |
| JP6772138B2 (ja) | 2014-12-19 | 2020-10-21 | メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー | 細胞内のＢｏＮＴ／Ｅの生物学的活性を決定するための手段及び方法 |
| TWI704156B (zh) | 2015-03-04 | 2020-09-11 | 德商曼茲法瑪股份有限公司 | 用於增進肉毒桿菌神經毒素進入細胞之特定攝取的方法 |
-
2014
- 2014-06-26 JP JP2016522499A patent/JP6608357B2/ja active Active
- 2014-06-26 KR KR1020157036607A patent/KR102266362B1/ko active IP Right Grant
- 2014-06-26 WO PCT/EP2014/063531 patent/WO2014207109A1/en active Application Filing
- 2014-06-26 LT LTEP14733620.0T patent/LT3014267T/lt unknown
- 2014-06-26 CA CA2913686A patent/CA2913686C/en active Active
- 2014-06-26 SG SG11201510685UA patent/SG11201510685UA/en unknown
- 2014-06-26 AU AU2014301116A patent/AU2014301116B2/en active Active
- 2014-06-26 RU RU2015149695A patent/RU2704808C2/ru active
- 2014-06-26 ES ES14733620T patent/ES2699432T3/es active Active
- 2014-06-26 PL PL14733620T patent/PL3014267T3/pl unknown
- 2014-06-26 MX MX2015016767A patent/MX360513B/es active IP Right Grant
- 2014-06-26 CN CN201480036574.2A patent/CN105339790B/zh active Active
- 2014-06-26 SI SI201430991T patent/SI3014267T1/sl unknown
- 2014-06-26 EP EP14733620.0A patent/EP3014267B1/en active Active
- 2014-06-26 US US14/901,123 patent/US11976110B2/en active Active
- 2014-06-27 TW TW103122320A patent/TWI632369B/zh active
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2016
- 2016-03-17 HK HK16103162.8A patent/HK1215299A1/zh unknown
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2018
- 2018-11-27 HR HRP20181989TT patent/HRP20181989T1/hr unknown
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| MX2015016767A (es) | 2016-04-13 |
| KR102266362B1 (ko) | 2021-06-17 |
| CN105339790A (zh) | 2016-02-17 |
| US20160202245A1 (en) | 2016-07-14 |
| RU2015149695A (ru) | 2017-08-03 |
| AU2014301116B2 (en) | 2019-11-14 |
| RU2704808C2 (ru) | 2019-10-31 |
| HRP20181989T1 (hr) | 2019-01-25 |
| HK1215299A1 (zh) | 2016-08-19 |
| JP6608357B2 (ja) | 2019-11-20 |
| SI3014267T1 (sl) | 2019-01-31 |
| AU2014301116A1 (en) | 2015-12-03 |
| PL3014267T3 (pl) | 2019-05-31 |
| US11976110B2 (en) | 2024-05-07 |
| EP3014267A1 (en) | 2016-05-04 |
| CA2913686A1 (en) | 2014-12-31 |
| CN105339790B (zh) | 2018-04-17 |
| ES2699432T3 (es) | 2019-02-11 |
| MX360513B (es) | 2018-11-07 |
| KR20160023715A (ko) | 2016-03-03 |
| JP2016528884A (ja) | 2016-09-23 |
| WO2014207109A1 (en) | 2014-12-31 |
| TWI632369B (zh) | 2018-08-11 |
| CA2913686C (en) | 2021-08-03 |
| EP3014267B1 (en) | 2018-11-07 |
| TW201537173A (zh) | 2015-10-01 |
| IL243157B (en) | 2019-01-31 |
| SG11201510685UA (en) | 2016-01-28 |
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