JP2007516728A5 - - Google Patents
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- Publication number
- JP2007516728A5 JP2007516728A5 JP2006547496A JP2006547496A JP2007516728A5 JP 2007516728 A5 JP2007516728 A5 JP 2007516728A5 JP 2006547496 A JP2006547496 A JP 2006547496A JP 2006547496 A JP2006547496 A JP 2006547496A JP 2007516728 A5 JP2007516728 A5 JP 2007516728A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- definitive endoderm
- cell population
- pluripotent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims 33
- 210000004039 endoderm cell Anatomy 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 238000004113 cell culture Methods 0.000 claims 12
- 210000001671 embryonic stem cell Anatomy 0.000 claims 6
- 108010023082 activin A Proteins 0.000 claims 5
- 239000003102 growth factor Substances 0.000 claims 5
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 4
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 4
- 210000005260 human cell Anatomy 0.000 claims 3
- 108010023079 activin B Proteins 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 210000004602 germ cell Anatomy 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 210000000472 morula Anatomy 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 108010059616 Activins Proteins 0.000 claims 1
- 101000652324 Homo sapiens Transcription factor SOX-17 Proteins 0.000 claims 1
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 1
- 102100030243 Transcription factor SOX-17 Human genes 0.000 claims 1
- 239000000488 activin Substances 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 238000012606 in vitro cell culture Methods 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53200403P | 2003-12-23 | 2003-12-23 | |
| US60/532,004 | 2003-12-23 | ||
| US58656604P | 2004-07-09 | 2004-07-09 | |
| US60/586,566 | 2004-07-09 | ||
| US58794204P | 2004-07-14 | 2004-07-14 | |
| US60/587,942 | 2004-07-14 | ||
| PCT/US2004/043696 WO2005063971A2 (en) | 2003-12-23 | 2004-12-23 | Definitive endoderm |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011168363A Division JP5669688B2 (ja) | 2003-12-23 | 2011-08-01 | 胚体内胚葉 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007516728A JP2007516728A (ja) | 2007-06-28 |
| JP2007516728A5 true JP2007516728A5 (enExample) | 2010-08-12 |
| JP4819697B2 JP4819697B2 (ja) | 2011-11-24 |
Family
ID=34743694
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547496A Expired - Lifetime JP4819697B2 (ja) | 2003-12-23 | 2004-12-23 | 胚体内胚葉 |
| JP2011168363A Expired - Lifetime JP5669688B2 (ja) | 2003-12-23 | 2011-08-01 | 胚体内胚葉 |
| JP2014186172A Expired - Lifetime JP6356021B2 (ja) | 2003-12-23 | 2014-09-12 | 胚体内胚葉 |
| JP2015111659A Pending JP2015163081A (ja) | 2003-12-23 | 2015-06-01 | 胚体内胚葉 |
| JP2016232292A Expired - Lifetime JP6574158B2 (ja) | 2003-12-23 | 2016-11-30 | 胚体内胚葉 |
| JP2018130280A Pending JP2018171071A (ja) | 2003-12-23 | 2018-07-09 | 胚体内胚葉 |
| JP2020032178A Expired - Lifetime JP7045407B2 (ja) | 2003-12-23 | 2020-02-27 | 胚体内胚葉 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011168363A Expired - Lifetime JP5669688B2 (ja) | 2003-12-23 | 2011-08-01 | 胚体内胚葉 |
| JP2014186172A Expired - Lifetime JP6356021B2 (ja) | 2003-12-23 | 2014-09-12 | 胚体内胚葉 |
| JP2015111659A Pending JP2015163081A (ja) | 2003-12-23 | 2015-06-01 | 胚体内胚葉 |
| JP2016232292A Expired - Lifetime JP6574158B2 (ja) | 2003-12-23 | 2016-11-30 | 胚体内胚葉 |
| JP2018130280A Pending JP2018171071A (ja) | 2003-12-23 | 2018-07-09 | 胚体内胚葉 |
| JP2020032178A Expired - Lifetime JP7045407B2 (ja) | 2003-12-23 | 2020-02-27 | 胚体内胚葉 |
Country Status (15)
| Country | Link |
|---|---|
| US (8) | US7510876B2 (enExample) |
| EP (2) | EP1709159B1 (enExample) |
| JP (7) | JP4819697B2 (enExample) |
| KR (1) | KR101221302B1 (enExample) |
| CN (2) | CN103898047B (enExample) |
| AU (2) | AU2004309421B2 (enExample) |
| CA (2) | CA2807342C (enExample) |
| DK (2) | DK2722387T3 (enExample) |
| EA (1) | EA200601231A1 (enExample) |
| HK (3) | HK1197082A1 (enExample) |
| IL (1) | IL176336A (enExample) |
| MX (2) | MXPA06007252A (enExample) |
| NZ (1) | NZ547920A (enExample) |
| SG (1) | SG149061A1 (enExample) |
| WO (1) | WO2005063971A2 (enExample) |
Families Citing this family (150)
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