JP2007516728A5 - - Google Patents

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Publication number
JP2007516728A5
JP2007516728A5 JP2006547496A JP2006547496A JP2007516728A5 JP 2007516728 A5 JP2007516728 A5 JP 2007516728A5 JP 2006547496 A JP2006547496 A JP 2006547496A JP 2006547496 A JP2006547496 A JP 2006547496A JP 2007516728 A5 JP2007516728 A5 JP 2007516728A5
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cells
cell
definitive endoderm
cell population
pluripotent
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JP2006547496A
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Japanese (ja)
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JP2007516728A (ja
JP4819697B2 (ja
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Priority claimed from PCT/US2004/043696 external-priority patent/WO2005063971A2/en
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Publication of JP2007516728A5 publication Critical patent/JP2007516728A5/ja
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Publication of JP4819697B2 publication Critical patent/JP4819697B2/ja
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JP2006547496A 2003-12-23 2004-12-23 胚体内胚葉 Expired - Lifetime JP4819697B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US53200403P 2003-12-23 2003-12-23
US60/532,004 2003-12-23
US58656604P 2004-07-09 2004-07-09
US60/586,566 2004-07-09
US58794204P 2004-07-14 2004-07-14
US60/587,942 2004-07-14
PCT/US2004/043696 WO2005063971A2 (en) 2003-12-23 2004-12-23 Definitive endoderm

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011168363A Division JP5669688B2 (ja) 2003-12-23 2011-08-01 胚体内胚葉

Publications (3)

Publication Number Publication Date
JP2007516728A JP2007516728A (ja) 2007-06-28
JP2007516728A5 true JP2007516728A5 (enExample) 2010-08-12
JP4819697B2 JP4819697B2 (ja) 2011-11-24

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ID=34743694

Family Applications (7)

Application Number Title Priority Date Filing Date
JP2006547496A Expired - Lifetime JP4819697B2 (ja) 2003-12-23 2004-12-23 胚体内胚葉
JP2011168363A Expired - Lifetime JP5669688B2 (ja) 2003-12-23 2011-08-01 胚体内胚葉
JP2014186172A Expired - Lifetime JP6356021B2 (ja) 2003-12-23 2014-09-12 胚体内胚葉
JP2015111659A Pending JP2015163081A (ja) 2003-12-23 2015-06-01 胚体内胚葉
JP2016232292A Expired - Lifetime JP6574158B2 (ja) 2003-12-23 2016-11-30 胚体内胚葉
JP2018130280A Pending JP2018171071A (ja) 2003-12-23 2018-07-09 胚体内胚葉
JP2020032178A Expired - Lifetime JP7045407B2 (ja) 2003-12-23 2020-02-27 胚体内胚葉

Family Applications After (6)

Application Number Title Priority Date Filing Date
JP2011168363A Expired - Lifetime JP5669688B2 (ja) 2003-12-23 2011-08-01 胚体内胚葉
JP2014186172A Expired - Lifetime JP6356021B2 (ja) 2003-12-23 2014-09-12 胚体内胚葉
JP2015111659A Pending JP2015163081A (ja) 2003-12-23 2015-06-01 胚体内胚葉
JP2016232292A Expired - Lifetime JP6574158B2 (ja) 2003-12-23 2016-11-30 胚体内胚葉
JP2018130280A Pending JP2018171071A (ja) 2003-12-23 2018-07-09 胚体内胚葉
JP2020032178A Expired - Lifetime JP7045407B2 (ja) 2003-12-23 2020-02-27 胚体内胚葉

Country Status (15)

Country Link
US (8) US7510876B2 (enExample)
EP (2) EP1709159B1 (enExample)
JP (7) JP4819697B2 (enExample)
KR (1) KR101221302B1 (enExample)
CN (2) CN103898047B (enExample)
AU (2) AU2004309421B2 (enExample)
CA (2) CA2807342C (enExample)
DK (2) DK2722387T3 (enExample)
EA (1) EA200601231A1 (enExample)
HK (3) HK1197082A1 (enExample)
IL (1) IL176336A (enExample)
MX (2) MXPA06007252A (enExample)
NZ (1) NZ547920A (enExample)
SG (1) SG149061A1 (enExample)
WO (1) WO2005063971A2 (enExample)

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2456981C (en) * 2001-08-06 2012-02-28 Bresagen, Inc. Alternative compositions and methods for the culture of stem cells
CA2692325C (en) * 2001-12-07 2015-10-20 Geron Corporation Islet cells from human embryonic stem cells
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
EP1543110A4 (en) 2002-05-17 2006-09-06 Sinai School Medicine POPULATION OF DEFINITIVE ENDODERMIC CELLS AND MESODERMAL
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
WO2007059007A2 (en) 2005-11-14 2007-05-24 Cythera, Inc. Markers of definitive endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
CN103898047B (zh) * 2003-12-23 2020-03-03 维亚希特公司 定形内胚层
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US20050266554A1 (en) * 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
EP2377922B1 (en) * 2004-04-27 2020-04-08 Viacyte, Inc. PDX1 expressing endoderm
WO2006025937A2 (en) * 2004-07-07 2006-03-09 The University Of North Carolina At Chapel Hill Embryonic stem cell derivatives, and methods of making and using the same
EP3505622A1 (en) * 2004-07-09 2019-07-03 Viacyte, Inc. Preprimitive streak and mesendoderm cells
WO2006020919A2 (en) * 2004-08-13 2006-02-23 University Of Georgia Research Foundation, Inc. Compositions and methods for self-renewal and differentiation in human embryonic stem cells
WO2006040763A2 (en) 2004-10-12 2006-04-20 Technion Research & Development Foundation Ltd. Isolated primate embryonic cells and methods of generating and using same
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
JP4824036B2 (ja) * 2004-12-23 2011-11-24 ヴィアサイト,インコーポレイテッド 胚体内胚葉細胞の増殖
EP1838843B1 (en) * 2004-12-23 2019-07-10 Viacyte, Inc. Expansion of definitive endoderm cells
AU2006210955A1 (en) * 2005-01-31 2006-08-10 Es Cell International Pte Ltd. Directed differentiation of embryonic stem cells and uses thereof
US7642091B2 (en) 2005-02-24 2010-01-05 Jau-Nan Lee Human trophoblast stem cells and use thereof
ES2400916T3 (es) 2005-06-08 2013-04-15 Janssen Biotech, Inc. Una terapia celular para degeneración ocular
CA2626152A1 (en) 2005-10-24 2007-05-03 Agency For Science, Technology And Research Methods of specifying mesodermal, endodermal and mesoendodermal cell fates
JP5404047B2 (ja) * 2005-10-27 2014-01-29 ヴィアサイト,インコーポレイテッド Pdx1発現背側及び腹側前腸内胚葉
JP4463189B2 (ja) 2005-11-22 2010-05-12 Nec東芝スペースシステム株式会社 探索機能付きモバイル装置
JP5830217B2 (ja) * 2006-02-23 2015-12-09 ヴィアサイト インコーポレイテッド 分化可能細胞の培養に有用な組成物及び方法
US11254916B2 (en) 2006-03-02 2022-02-22 Viacyte, Inc. Methods of making and using PDX1-positive pancreatic endoderm cells
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
EP1999253B1 (en) * 2006-03-02 2019-05-22 Viacyte, Inc. Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
GB0615327D0 (en) * 2006-03-30 2006-09-13 Univ Edinburgh Culture medium containing kinase inhibitors and uses thereof
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
WO2007127454A2 (en) 2006-04-28 2007-11-08 Cythera, Inc. Hepatocyte lineage cells
US8685730B2 (en) 2006-05-02 2014-04-01 Wisconsin Alumni Research Foundation Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage
GB2452186B (en) * 2006-05-02 2011-01-26 Wisconsin Alumni Res Found Method of differentiating stem cells into cells of the endoderm and pancreatic lineage
US20090298169A1 (en) * 2006-06-02 2009-12-03 The University Of Georgia Research Foundation Pancreatic and Liver Endoderm Cells and Tissue by Differentiation of Definitive Endoderm Cells Obtained from Human Embryonic Stems
US8415153B2 (en) 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
US8874380B2 (en) 2010-12-09 2014-10-28 Rutgers, The State University Of New Jersey Method of overcoming therapeutic limitations of nonuniform distribution of radiopharmaceuticals and chemotherapy drugs
AU2007277364B2 (en) 2006-07-26 2010-08-12 Viacyte, Inc. Methods of producing pancreatic hormones
WO2008048647A1 (en) * 2006-10-17 2008-04-24 Cythera, Inc. Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
CA2693481A1 (en) 2007-07-20 2009-01-29 Cellartis Ab A novel population of hepatocytes derived via definitive endoderm (de-hep) from human blastocysts derived stem cells
CA3207103A1 (en) 2007-07-31 2009-02-05 Janssen Biotech, Inc. Differentiation of human embryonic stem cells to pancreatic endocrine
US7695963B2 (en) * 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
ATE523585T1 (de) 2007-11-27 2011-09-15 Lifescan Inc Differenzierung menschlicher embryonaler stammzellen
EP2227487A1 (en) 2007-12-28 2010-09-15 Novo Nordisk A/S Ddr1-mediated cell purification of pancreatic endocrine cells through their progenitors
RU2551772C2 (ru) 2008-02-21 2015-05-27 Сентокор Орто Байотек Инк. Способы, поверхностно-модифицированные носители и композиции для иммобилизации, культивирования и открепления клеток
CN101983336A (zh) 2008-04-03 2011-03-02 诺沃-诺迪斯克有限公司 Dner介导的胰腺内分泌前祖细胞及其子代的细胞纯化
US8338170B2 (en) 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
WO2009131568A1 (en) 2008-04-21 2009-10-29 Cythera, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
US7939322B2 (en) * 2008-04-24 2011-05-10 Centocor Ortho Biotech Inc. Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
US8623648B2 (en) * 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
WO2009154606A1 (en) 2008-06-03 2009-12-23 Cythera, Inc. Growth factors for production of definitive endoderm
US20090298178A1 (en) * 2008-06-03 2009-12-03 D Amour Kevin Allen Growth factors for production of definitive endoderm
BRPI0914116A2 (pt) 2008-06-30 2019-09-17 Centocor Ortho Biotech Inc diferenciação de células-tronco pluripotentes
JP2011526784A (ja) * 2008-06-30 2011-10-20 セントコア・オーソ・バイオテツク・インコーポレーテツド 多能性幹細胞の分化
CN107435038B (zh) 2008-10-31 2021-07-09 詹森生物科技公司 人胚胎干细胞向胰腺内分泌谱系的分化
RU2522001C2 (ru) 2008-10-31 2014-07-10 Сентокор Орто Байотек Инк. Дифференцирование человеческих эмбриональных стволовых клеток в линию панкреатических эндокринных клеток
US8008075B2 (en) * 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
CA2742583C (en) 2008-11-04 2022-09-27 Viacyte, Inc. Stem cell aggregate suspension compositions and methods for differentiation thereof
US8895300B2 (en) 2008-11-04 2014-11-25 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
CA2743641C (en) 2008-11-14 2024-03-26 Viacyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
CA2744227C (en) 2008-11-20 2018-10-02 Centocor Ortho Biotech Inc. Methods and compositions for cell attachment and cultivation on planar substrates
JP2012509085A (ja) 2008-11-20 2012-04-19 ヤンセン バイオテツク,インコーポレーテツド マイクロキャリア上での多能性幹細胞の培養
CA2745742A1 (en) * 2008-12-03 2010-06-10 International Stem Cell Corporation Methods of deriving differentiated cells from stem cells
US8507274B2 (en) 2009-02-06 2013-08-13 President And Fellows Of Harvard College Compositions and methods for promoting the generation of definitive endoderm
EP2233566A1 (en) 2009-03-17 2010-09-29 Vrije Universiteit Brussel Generation of pancreatic progenitor cells
EP2421957B1 (en) 2009-04-22 2020-11-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
JP2012527880A (ja) * 2009-05-29 2012-11-12 ノヴォ ノルディスク アー/エス hPS細胞由来の胚体内胚葉からの特定の内胚葉の派生
GB0911060D0 (en) 2009-06-26 2009-08-12 Ge Healthcare Uk Ltd Methods for predicting the toxicity of a chemical
SG177481A1 (en) 2009-07-20 2012-02-28 Janssen Biotech Inc Differentiation of human embryonic stem cells
EP2456858B1 (en) 2009-07-20 2018-08-29 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
CA2768720C (en) 2009-07-20 2018-12-18 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
PH12012500818A1 (en) * 2009-10-29 2019-11-29 Janssen Biotech Inc Pluripotent stem cells
SG181685A1 (en) * 2009-12-23 2012-07-30 Centocor Ortho Biotech Inc Differentiation of human embryonic stem cells
CA2784415C (en) 2009-12-23 2019-06-18 Jean Xu Differentiation of human embryonic stem cells
WO2011100291A1 (en) * 2010-02-09 2011-08-18 The Regents Of The University Of California Method for identifying pancreatic progenitor cells
SG183535A1 (en) 2010-03-01 2012-10-30 Janssen Biotech Inc Methods for purifying cells derived from pluripotent stem cells
WO2011133599A2 (en) * 2010-04-20 2011-10-27 International Stem Cell Corporation Physiological methods for isolation of high purity cell populations
WO2011140441A2 (en) * 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
MX351515B (es) 2010-05-12 2017-10-17 Janssen Biotech Inc Diferenciacion de celulas madre embrionarias humanas.
AU2011296383B2 (en) 2010-08-31 2016-03-10 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
ES2658146T3 (es) * 2010-08-31 2018-03-08 Janssen Biotech, Inc. Diferenciación de células madre embrionarias humanas
CN103221536B (zh) 2010-08-31 2016-08-31 詹森生物科技公司 人胚胎干细胞的分化
EP2636731B1 (en) 2010-11-02 2016-07-13 National University Corporation Kumamoto University Method of producing intestinal cells
CA2818234C (en) 2010-11-15 2023-03-07 Jau-Nan Lee Generation of neural stem cells from human trophoblast stem cells
WO2012115619A1 (en) 2011-02-21 2012-08-30 Viacyte, Inc. Loading system for an encapsulation device
CN108220224A (zh) 2011-06-21 2018-06-29 诺沃—诺迪斯克有限公司 自多潜能干细胞有效诱导定形内胚层
AU2012355698B2 (en) 2011-12-22 2018-11-29 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into single hormonal insulin positive cells
US9434920B2 (en) 2012-03-07 2016-09-06 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
JP6450674B2 (ja) 2012-05-07 2019-01-09 ヤンセン バイオテツク,インコーポレーテツド ヒト胚性幹細胞の膵臓の内胚葉への分化
EP2857500B1 (en) 2012-05-25 2018-01-31 Saitama Medical University Method for producing pancreatic hormone-producing cell, pancreatic hormone-producing cell, and differentiation/induction promoter
MX358590B (es) 2012-06-08 2018-08-24 Janssen Biotech Inc Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas.
JP6494515B2 (ja) * 2012-10-19 2019-04-03 エージェンシー フォー サイエンス, テクノロジー アンド リサーチ 幹細胞を1又は2以上の細胞系列に分化させる方法
AU2013248265B2 (en) 2012-11-08 2018-11-01 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
JP6457947B2 (ja) 2012-11-30 2019-01-23 アクセラレイテッド・バイオサイエンシズ・コーポレーション miR−124を調節することにより幹細胞を分化させる方法
AU2013370228B2 (en) 2012-12-31 2018-10-18 Janssen Biotech, Inc. Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells
SG10201707811XA (en) 2012-12-31 2017-11-29 Janssen Biotech Inc Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators
US10344264B2 (en) 2012-12-31 2019-07-09 Janssen Biotech, Inc. Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
CA2902857C (en) 2013-02-27 2022-11-29 The Regents Of The University Of California Generation of thymic epithelial progenitor cells in vitro
AU2014225352B2 (en) 2013-03-07 2017-02-09 Viacyte, Inc. 3-dimensional large capacity cell encapsulation device assembly
USD720469S1 (en) 2013-03-07 2014-12-30 Viacyte, Inc. Cell encapsulation device
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
WO2014165663A1 (en) 2013-04-03 2014-10-09 Cellular Dynamics International, Inc. Methods and compositions for culturing endoderm progenitor cells in suspension
CN105142570B (zh) 2013-04-24 2018-06-22 雀巢产品技术援助有限公司 包封装置
TW201536799A (zh) 2013-05-24 2015-10-01 Univ Saitama Medical 新穎之胜肽及其用途
EP3008170A4 (en) 2013-06-11 2016-11-09 Harvard College SC-CELLS AND COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF
US11051900B2 (en) 2014-04-16 2021-07-06 Viacyte, Inc. Tools and instruments for use with implantable encapsulation devices
SG10201810739VA (en) 2014-05-16 2019-01-30 Janssen Biotech Inc Use of small molecules to enhance mafa expression in pancreatic endocrine cells
JP6687544B2 (ja) 2014-05-28 2020-04-22 チルドレンズ ホスピタル メディカル センター 前駆細胞を指向性分化によって胃組織に変換するための方法及びシステム
US11584916B2 (en) 2014-10-17 2023-02-21 Children's Hospital Medical Center Method of making in vivo human small intestine organoids from pluripotent stem cells
SG11201704291QA (en) 2014-11-26 2017-06-29 Accelerated Biosciences Corp Induced hepatocytes and uses thereof
ES2985135T3 (es) 2014-12-18 2024-11-04 Harvard College Procedimientos para generar células ß derivadas de células madre y usos de las mismas
US10443042B2 (en) 2014-12-18 2019-10-15 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof
CN107614678B (zh) 2014-12-18 2021-04-30 哈佛学院校长同事会 干细胞来源的β细胞的产生方法及其使用方法
KR102700499B1 (ko) 2014-12-19 2024-08-28 얀센 바이오테크 인코포레이티드 만능성 줄기 세포의 현탁 배양
PL3286300T3 (pl) 2015-04-24 2021-05-04 University Of Copenhagen Izolacja bona fide komórek progenitorowych trzustki
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
MA45502A (fr) 2016-06-21 2019-04-24 Janssen Biotech Inc Génération de cellules bêta fonctionnelles dérivées de cellules souches pluripotentes humaines ayant une respiration mitochondriale glucose-dépendante et une réponse en sécrétion d'insuline en deux phases
SG11201903697WA (en) 2016-11-04 2019-05-30 Childrens Hospital Med Ct Liver organoid compositions and methods of making and using same
CN110167455B (zh) 2016-11-10 2022-10-11 韦尔赛特公司 含有pdx1胰腺内胚层细胞的细胞递送装置及其方法
NZ753873A (en) 2016-12-05 2023-01-27 Children’S Hospital Medical Center Colonic organoids and methods of making and using same
JP6485883B2 (ja) * 2017-03-01 2019-03-20 株式会社大一商会 遊技機
WO2018191673A1 (en) 2017-04-14 2018-10-18 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
IL308120B2 (en) 2017-06-14 2024-12-01 Vertex Pharma Devices and methods for delivering therapeutics
US10391156B2 (en) 2017-07-12 2019-08-27 Viacyte, Inc. University donor cells and related methods
JP2020536529A (ja) * 2017-10-10 2020-12-17 チルドレンズ ホスピタル メディカル センター 食道組織および/または臓器組成物およびそれを作製する方法
CA2983845C (en) 2017-10-26 2024-01-30 University Of Copenhagen Generation of glucose-responsive beta cells
CA3081762A1 (en) 2017-11-15 2019-05-23 Semma Therapeutics, Inc. Islet cell manufacturing compositions and methods of use
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
CA3106634A1 (en) 2018-07-26 2020-01-30 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
CA3108275A1 (en) 2018-08-10 2020-02-13 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
US12378572B2 (en) 2018-09-07 2025-08-05 Crispr Therapeutics Ag Universal donor cells
AU2019339410A1 (en) 2018-09-12 2021-04-15 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
WO2020227314A1 (en) 2019-05-06 2020-11-12 Accelerated Biosciences Corp. Precursory regulatory cytotrophoblast cells and uses thereof
AU2020283150B2 (en) 2019-05-31 2023-08-17 Viacyte, Inc. Cell encapsulation devices with controlled oxygen diffusion distances
US20220233298A1 (en) 2019-05-31 2022-07-28 W. L. Gore & Associates, Inc. A biocompatible membrane composite
US20220234006A1 (en) 2019-05-31 2022-07-28 W. L. Gore & Associates, Inc. A biocompatible membrane composite
AU2020283056B2 (en) 2019-05-31 2023-06-08 Viacyte, Inc. A biocompatible membrane composite
JP7610533B2 (ja) 2019-05-31 2025-01-08 チルドレンズ ホスピタル メディカル センター 造血幹細胞の生成および拡大方法
EP4025690A1 (en) 2019-09-05 2022-07-13 CRISPR Therapeutics AG Universal donor cells
BR112022004031A2 (pt) 2019-09-05 2022-08-16 Crispr Therapeutics Ag Células doadoras universais
US12188051B2 (en) 2020-05-27 2025-01-07 The Regents Of The University Of Michigan Compositions and methods for obtaining vascularized human intestinal organoid tissue, and related uses thereof
JP7459254B2 (ja) * 2020-06-19 2024-04-01 富士フイルム株式会社 情報処理装置、情報処理装置の作動方法、情報処理装置の作動プログラム
CN116057185A (zh) 2020-08-15 2023-05-02 雷杰纳荣制药公司 治疗具有编码降钙素受体(calcr)的变体核酸分子的受试者的肥胖症
US11578309B2 (en) 2020-12-31 2023-02-14 Crispr Therapeutics Ag Universal donor cells
WO2024151541A1 (en) 2023-01-09 2024-07-18 Sana Biotechnology, Inc. Type-1 diabetes autoimmune mouse
WO2024243236A2 (en) 2023-05-22 2024-11-28 Sana Biotechnology, Inc. Methods of delivery of islet cells and related methods

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1234567A (en) * 1915-09-14 1917-07-24 Edward J Quigley Soft collar.
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5869620A (en) 1986-09-02 1999-02-09 Enzon, Inc. Multivalent antigen-binding proteins
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US6165993A (en) 1992-03-23 2000-12-26 University Of Massachusetts Medical Center DNA vaccines against rotavirus infections
US5453357A (en) 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US7153684B1 (en) 1992-10-08 2006-12-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5690926A (en) 1992-10-08 1997-11-25 Vanderbilt University Pluripotential embryonic cells and methods of making same
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US6015671A (en) 1995-06-07 2000-01-18 Indiana University Foundation Myocardial grafts and cellular compositions
US6090592A (en) 1994-08-03 2000-07-18 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid on supports
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
JP3945846B2 (ja) 1995-11-09 2007-07-18 武田薬品工業株式会社 膵臓機能改善剤
CA2247502A1 (en) 1996-02-28 1997-09-04 Vanderbilt University Compositions and methods of making embryonic stem cells
US6117635A (en) 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
EP0938571B8 (en) 1996-10-28 2008-07-02 University of Lausanne Method for the oligomerisation of peptides
AU5734998A (en) 1997-01-10 1998-08-03 Life Technologies, Inc. Embryonic stem cell serum replacement
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
US5866366A (en) 1997-07-01 1999-02-02 Smithkline Beecham Corporation gidB
BR9813202B1 (pt) 1997-09-15 2011-11-01 complexo de administração de genes; processo de transdução de células com material genético estranho, composição útil para administração de material genético e uso de um complexo de administração de genes.
WO1999020741A1 (en) 1997-10-23 1999-04-29 Geron Corporation Methods and materials for the growth of primate-derived primordial stem cells
US6117986A (en) 1998-06-10 2000-09-12 Intergen Company, L.P. Pyrimidines linked to a quencher
US6921811B2 (en) * 1998-09-22 2005-07-26 Biosurface Engineering Technologies, Inc. Bioactive coating composition and methods
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
DE19852800C1 (de) 1998-11-16 2000-04-13 Univ Albert Ludwigs Freiburg Verfahren zur Herstellung von Antikörpern gegen ein Polypeptid, von dem die kodierende Nukleinsäure bekannt ist
GB9903804D0 (en) 1999-02-20 1999-04-14 Univ Sheffield Pluripotential cells-2
US6872389B1 (en) 1999-07-08 2005-03-29 Rhode Island Hospital Liver stem cell
WO2001053465A1 (en) 2000-01-21 2001-07-26 The Johns Hopkins University School Of Medicine Human embryoid body-derived cells
US7005252B1 (en) 2000-03-09 2006-02-28 Wisconsin Alumni Research Foundation Serum free cultivation of primate embryonic stem cells
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
US7256042B2 (en) 2000-04-27 2007-08-14 Geron Corporation Process for making hepatocytes from pluripotent stem cells
JP4426064B2 (ja) 2000-05-31 2010-03-03 独立行政法人科学技術振興機構 脊椎動物の膵臓のインビトロ形成方法
US7045353B2 (en) * 2000-08-01 2006-05-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Directed differentiation of human embryonic cells
AU2002226075A1 (en) 2000-10-23 2002-05-06 University Of Kansas Cadherin peptides for drug delivery and inhibition of tumor metastasis/invasion
EP1395652A2 (en) 2000-11-30 2004-03-10 Stemron, Inc. Isolated homozygous stem cells differentiated cells derived therefrom and materials and methods for making and using same
EP1366148A2 (en) * 2001-01-24 2003-12-03 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES Differentiation of stem cells to pancreatic endocrine cells
EP1393066A4 (en) 2001-05-15 2006-01-25 Rappaport Family Inst For Res INSULIN-PRODUCING CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS
EP1401282A4 (en) 2001-05-25 2005-03-30 Cythera Inc DIFFERENTIATION OF STEM CELLS
EP1407261A4 (en) 2001-06-13 2006-11-22 Massachusetts Inst Technology BIOREACTORS FOR IN VIVO REACTIONS
AU2002312514A1 (en) 2001-06-14 2003-01-02 Regents Of The University Of California Hoxd3 compositions ad methods for improved wound healing
EP1298201A1 (en) 2001-09-27 2003-04-02 Cardion AG Process for the production of cells exhibiting an islet-beta-cell-like state
CA2468292A1 (en) * 2001-11-26 2003-06-05 Advanced Cell Technology, Inc. Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
CA2692325C (en) * 2001-12-07 2015-10-20 Geron Corporation Islet cells from human embryonic stem cells
US20030138949A1 (en) 2001-12-12 2003-07-24 Anil Bhushan Methods for the regeneration of pancreatic islets and expansion of pancreatic endocrine cells
US20030162290A1 (en) 2002-01-25 2003-08-28 Kazutomo Inoue Method for inducing differentiation of embryonic stem cells into functioning cells
US20030235563A1 (en) * 2002-04-19 2003-12-25 Strom Stephen C. Placental derived stem cells and uses thereof
US20060003446A1 (en) * 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
EP1543110A4 (en) * 2002-05-17 2006-09-06 Sinai School Medicine POPULATION OF DEFINITIVE ENDODERMIC CELLS AND MESODERMAL
EP1507552A2 (en) 2002-05-28 2005-02-23 Novocell, Inc. Methods, compositions, and growth and differentiation factors for insulin-producing cells
WO2003102134A2 (en) * 2002-05-28 2003-12-11 Becton, Dickinson And Company Pancreatic acinar cells into insulin producing cells
WO2004050827A2 (en) 2002-12-05 2004-06-17 Technion Research & Development Foundation Ltd. Cultured human pancreatic islets, and uses thereof
FR2849043B1 (fr) * 2002-12-24 2005-07-08 Gemac Procede de fabrication d'un vecteur de molecules actives applicable dans le domaine de la diffusion de principes actifs et vecteur obtenu
US20060128018A1 (en) 2003-02-07 2006-06-15 Zwaka Thomas P Directed genetic modifications of human stem cells
US20070155661A1 (en) 2003-02-14 2007-07-05 The Board Of Trustees Of The Leland Standord Junior University Methods and compositions for modulating the development of stem cells
US20070154981A1 (en) 2003-02-14 2007-07-05 The Board Of Trustees Of The Leland Stanford Junior University Insulin-producing cells derived from stem cells
US20030224411A1 (en) 2003-03-13 2003-12-04 Stanton Lawrence W. Genes that are up- or down-regulated during differentiation of human embryonic stem cells
US20040229350A1 (en) 2003-05-12 2004-11-18 Nikolai Strelchenko Morula derived embryonic stem cells
EP1627912A4 (en) 2003-05-20 2007-12-12 Riken PREPARATION OF ENDODERMAL STEM CELLS
WO2005017131A2 (en) 2003-08-14 2005-02-24 THE GOUVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT F HEALTH AND HUMAN SERVICES Methods for the differentiation of human stem cells
US7091082B2 (en) * 2003-08-22 2006-08-15 The Board Of Trustees Of The University Of Illinois Semiconductor method and device
WO2005033294A2 (en) 2003-09-30 2005-04-14 Regents Of The University Of California Methods for maintaining hepatocytes in culture and for differentiating embryonic stem cells along a hepatocyte lineage
CN103898047B (zh) 2003-12-23 2020-03-03 维亚希特公司 定形内胚层
WO2007059007A2 (en) 2005-11-14 2007-05-24 Cythera, Inc. Markers of definitive endoderm
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US7985585B2 (en) * 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
WO2005097980A2 (en) 2004-03-26 2005-10-20 Geron Corporation New protocols for making hepatocytes from embryonic stem cells
WO2005097977A2 (en) 2004-04-01 2005-10-20 Wisconsin Alumni Research Foundation Differentiation of stem cells to endoderm and pancreatic lineage
DK2377922T3 (da) 2004-04-27 2020-05-04 Viacyte Inc PDX1-eksprimerende endoderm
EP3505622A1 (en) 2004-07-09 2019-07-03 Viacyte, Inc. Preprimitive streak and mesendoderm cells
CA2573283C (en) 2004-07-09 2023-03-14 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
WO2006020919A2 (en) 2004-08-13 2006-02-23 University Of Georgia Research Foundation, Inc. Compositions and methods for self-renewal and differentiation in human embryonic stem cells
JP2008514214A (ja) 2004-09-29 2008-05-08 セルアーティス アーベー ヒト胚盤胞由来幹細胞(hBS)から肝細胞様細胞を発生させる方法
AU2006210955A1 (en) 2005-01-31 2006-08-10 Es Cell International Pte Ltd. Directed differentiation of embryonic stem cells and uses thereof
WO2007002210A2 (en) 2005-06-20 2007-01-04 Bresagen, Inc. Embryonic stem cell culture compositions and methods of use thereof
EP1941032A2 (en) 2005-10-14 2008-07-09 Regents Of The University Of Minnesota Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype
JP5404047B2 (ja) 2005-10-27 2014-01-29 ヴィアサイト,インコーポレイテッド Pdx1発現背側及び腹側前腸内胚葉
GB0602063D0 (en) 2006-02-02 2006-03-15 Univ Manchester Cell Culture
AU2007277364B2 (en) 2006-07-26 2010-08-12 Viacyte, Inc. Methods of producing pancreatic hormones
WO2009154606A1 (en) * 2008-06-03 2009-12-23 Cythera, Inc. Growth factors for production of definitive endoderm

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