JP2008543338A5 - - Google Patents
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- Publication number
- JP2008543338A5 JP2008543338A5 JP2008518339A JP2008518339A JP2008543338A5 JP 2008543338 A5 JP2008543338 A5 JP 2008543338A5 JP 2008518339 A JP2008518339 A JP 2008518339A JP 2008518339 A JP2008518339 A JP 2008518339A JP 2008543338 A5 JP2008543338 A5 JP 2008543338A5
- Authority
- JP
- Japan
- Prior art keywords
- bmp
- cells
- culturing
- activin
- culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 15
- 238000012258 culturing Methods 0.000 claims 10
- 108010023082 activin A Proteins 0.000 claims 5
- 210000004413 cardiac myocyte Anatomy 0.000 claims 4
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 2
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims 2
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 claims 2
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 2
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 2
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 239000012679 serum free medium Substances 0.000 claims 2
- 108010059616 Activins Proteins 0.000 claims 1
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 1
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 1
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 1
- 239000000488 activin Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 210000002242 embryoid body Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69314105P | 2005-06-22 | 2005-06-22 | |
| US60/693,141 | 2005-06-22 | ||
| PCT/US2006/024060 WO2007002136A2 (en) | 2005-06-22 | 2006-06-20 | Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013135917A Division JP2013215206A (ja) | 2005-06-22 | 2013-06-28 | 心筋細胞系列細胞への霊長類多能性幹細胞の分化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008543338A JP2008543338A (ja) | 2008-12-04 |
| JP2008543338A5 true JP2008543338A5 (cg-RX-API-DMAC7.html) | 2009-04-16 |
| JP5560393B2 JP5560393B2 (ja) | 2014-07-23 |
Family
ID=37595761
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008518339A Expired - Fee Related JP5560393B2 (ja) | 2005-06-22 | 2006-06-20 | 心筋細胞系列細胞への霊長類多能性幹細胞の分化 |
| JP2013135917A Pending JP2013215206A (ja) | 2005-06-22 | 2013-06-28 | 心筋細胞系列細胞への霊長類多能性幹細胞の分化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013135917A Pending JP2013215206A (ja) | 2005-06-22 | 2013-06-28 | 心筋細胞系列細胞への霊長類多能性幹細胞の分化 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9062289B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1910518B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5560393B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR20130099253A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101228264B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2006262329B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2611809C (cg-RX-API-DMAC7.html) |
| GB (1) | GB2441718B (cg-RX-API-DMAC7.html) |
| IL (1) | IL187611A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007002136A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7666423B2 (en) * | 2006-07-28 | 2010-02-23 | Children's Memorial Hospital | Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells |
| US8106004B2 (en) * | 2006-07-28 | 2012-01-31 | Children's Memorial Hospital | Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells |
| EP2273996B8 (en) | 2008-03-27 | 2017-04-26 | Icahn School of Medicine at Mount Sinai | Human cardiovascular progenitor cells |
| EP4364797A3 (en) | 2009-10-19 | 2024-07-10 | FUJIFILM Cellular Dynamics, Inc. | Cardiomyocyte production |
| US9181529B2 (en) | 2010-10-19 | 2015-11-10 | Cellular Dynamics International, Inc. | Titration of differentiation medium components |
| JP6090855B2 (ja) | 2010-11-17 | 2017-03-08 | 国立大学法人京都大学 | 心筋細胞および/または心筋前駆細胞増殖剤ならびに心筋細胞および/または心筋前駆細胞の増殖方法 |
| EP2691512B1 (en) | 2011-03-29 | 2019-05-01 | Asterias Biotherapeutics, Inc. | Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells |
| JP6185907B2 (ja) | 2011-03-30 | 2017-08-23 | セルラー ダイナミクス インターナショナル, インコーポレイテッド | 神経分化のための多能性幹細胞の予備刺激 |
| JP5840855B2 (ja) | 2011-03-30 | 2016-01-06 | 学校法人東京女子医科大学 | 胚性幹細胞から心筋シートを製造する方法 |
| EP2691513A4 (en) | 2011-03-31 | 2014-09-03 | Iheart Japan Corp | NEW CARDIOMYOCYTE MARKER |
| AU2012268950B2 (en) | 2011-06-16 | 2016-02-04 | Dolby Video Compression, Llc | Entropy coding of motion vector differences |
| US9395354B2 (en) | 2011-07-21 | 2016-07-19 | The Board Of Trustees Of The Leland Stanford Junior University | Cardiomyocytes from induced pluripotent stem cells from patients and methods of use thereof |
| GB201121101D0 (en) * | 2011-12-08 | 2012-01-18 | Nhs Blood & Transplant | A method of preparing isolated cells and uses |
| EP2826855B1 (en) | 2012-03-15 | 2018-08-29 | iHeart Japan Corporation | Myocardial sheet |
| JP6373253B2 (ja) | 2012-07-17 | 2018-08-15 | 国立大学法人京都大学 | 新規心筋細胞マーカー |
| US9822342B2 (en) | 2013-05-14 | 2017-11-21 | Kyoto University | Method of efficiently inducing cardiomyocytes |
| CN105247041B (zh) | 2013-05-31 | 2018-04-20 | 爱心细胞有限公司 | 组入有水凝胶的层叠细胞膜片 |
| WO2014192312A1 (ja) * | 2013-05-31 | 2014-12-04 | 国立大学法人 東京医科歯科大学 | 正常な内向きのカリウム電流特性を有するiPS細胞由来心筋モデル細胞 |
| DE112014002780B4 (de) | 2013-06-11 | 2025-05-22 | President And Fellows Of Harvard College | SC-ß-Zellen und Zusammensetzungen und Verfahren zur Erzeugung der Zellen |
| EP3121276B1 (en) | 2014-03-20 | 2019-04-17 | Kyoto University | Cardiomyocyte sorting method |
| KR20160147800A (ko) * | 2014-05-06 | 2016-12-23 | 에프. 호프만-라 로슈 아게 | 다능성 줄기세포의 심근세포로의 분화 방법 |
| WO2016043168A1 (ja) * | 2014-09-16 | 2016-03-24 | 国立大学法人大阪大学 | 多能性幹細胞由来心筋細胞集団の製造方法 |
| WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
| CN107614678B (zh) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| WO2016100909A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
| US10556388B2 (en) * | 2015-04-22 | 2020-02-11 | Eastman Chemical Company | Polyester-based tape composites for wood reinforcement |
| US10968426B2 (en) | 2015-05-08 | 2021-04-06 | President And Fellows Of Harvard College | Universal donor stem cells and related methods |
| AU2018370029B2 (en) | 2017-11-15 | 2024-11-07 | Vertex Pharmaceuticals Incorporated | Islet cell manufacturing compositions and methods of use |
| CN111918961B (zh) | 2018-03-30 | 2023-10-24 | 国立大学法人京都大学 | 心肌细胞成熟促进剂 |
| JP7440868B2 (ja) | 2018-03-30 | 2024-02-29 | 国立大学法人京都大学 | 細胞の製造方法 |
| EP3778587B1 (en) | 2018-03-30 | 2023-10-04 | Orizuru Therapeutics, Inc. | Heterocyclic compound |
| JP7436990B2 (ja) | 2018-08-10 | 2024-02-22 | 国立大学法人京都大学 | カチオン性脂質を用いた心筋細胞へのトランスフェクション方法 |
| DK3835287T3 (da) | 2018-08-10 | 2025-01-02 | Takeda Pharmaceuticals Co | Kationisk lipid |
| AU2019320072A1 (en) | 2018-08-10 | 2021-02-25 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| EP4017508A1 (en) | 2019-08-23 | 2022-06-29 | Sana Biotechnology, Inc. | Cd24 expressing cells and uses thereof |
| KR20230074718A (ko) | 2020-08-13 | 2023-05-31 | 사나 바이오테크놀로지, 인크. | 저면역원성 세포로 감작된 환자를 치료하는 방법 및 관련 방법 및 조성물 |
| US20240226164A1 (en) | 2021-05-27 | 2024-07-11 | Sana Biotechnology, Inc. | Hypoimmunogenic cells comprising engineered hla-e or hla-g |
| KR20240046319A (ko) | 2021-07-14 | 2024-04-08 | 사나 바이오테크놀로지, 인크. | 저면역원성 세포에서의 y 염색체-연결 항원의 변경된 발현 |
| TW202321435A (zh) | 2021-08-11 | 2023-06-01 | 美商薩那生物科技公司 | 用於改變低免疫原性細胞中之基因表現之可誘導系統 |
| US20240425820A1 (en) | 2021-08-11 | 2024-12-26 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions |
| JP2024535677A (ja) | 2021-08-11 | 2024-10-02 | サナ バイオテクノロジー,インコーポレイテッド | 即時血液媒介性炎症反応を減少させるための同種細胞療法を目的とした遺伝子改変細胞 |
| AU2022326565A1 (en) | 2021-08-11 | 2024-02-08 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy |
| KR20230073749A (ko) | 2021-11-19 | 2023-05-26 | 주식회사 로킷헬스케어 | 박동형 심근 패치의 제조방법 및 이를 이용하여 제조된 박동형 심근 패치 |
| WO2023183313A1 (en) | 2022-03-22 | 2023-09-28 | Sana Biotechnology, Inc. | Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods |
| WO2024243236A2 (en) | 2023-05-22 | 2024-11-28 | Sana Biotechnology, Inc. | Methods of delivery of islet cells and related methods |
| WO2025054202A1 (en) | 2023-09-05 | 2025-03-13 | Sana Biotechnology, Inc. | Method of screening a sample comprising a transgene with a unique barcode |
| WO2025151838A1 (en) | 2024-01-12 | 2025-07-17 | Sana Biotechnology, Inc. | Safety switches to control in vitro and in vivo proliferation of cell therapy products |
Family Cites Families (65)
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|---|---|---|---|---|
| US4491632A (en) | 1979-10-22 | 1985-01-01 | The Massachusetts General Hospital | Process for producing antibodies to hepatitis virus and cell lines therefor |
| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| EP0043718B1 (en) | 1980-07-07 | 1984-11-28 | National Research Development Corporation | Improvements in or relating to cell lines |
| GB2197915B (en) | 1986-11-19 | 1990-11-14 | Rolls Royce Plc | Improvements in or relating to fluid bearings |
| WO1992013066A1 (en) | 1991-01-24 | 1992-08-06 | Loyola University Of Chicago | Mammalian cardiac myocyte cell line |
| US5543318A (en) * | 1991-06-12 | 1996-08-06 | Smith; David A. | Method of isolation, culture and proliferation of human atrial myocytes |
| US5523226A (en) * | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US5602301A (en) | 1993-11-16 | 1997-02-11 | Indiana University Foundation | Non-human mammal having a graft and methods of delivering protein to myocardial tissue |
| US6015671A (en) | 1995-06-07 | 2000-01-18 | Indiana University Foundation | Myocardial grafts and cellular compositions |
| DE4441327C1 (de) | 1994-11-22 | 1995-11-09 | Inst Pflanzengenetik & Kultur | Embryonale Herzmuskelzellen, ihre Herstellung und ihre Verwendung |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| AU725084B2 (en) | 1996-08-16 | 2000-10-05 | Mcw Research Foundation, Inc. | Bone morphogenetic protein and fibroblast growth factor compositions and methods for the induction of cardiogenesis |
| US20020061837A1 (en) * | 1996-09-05 | 2002-05-23 | Lough John W. | Bone morphogenetic protein and fibroblast growth factor compositions and methods for the induction of cardiogenesis |
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| US6331406B1 (en) | 1997-03-31 | 2001-12-18 | The John Hopkins University School Of Medicine | Human enbryonic germ cell and methods of use |
| US6110459A (en) | 1997-05-28 | 2000-08-29 | Mickle; Donald A. G. | Transplants for myocardial scars and methods and cellular preparations |
| US6099832A (en) | 1997-05-28 | 2000-08-08 | Genzyme Corporation | Transplants for myocardial scars |
| ATE307195T1 (de) | 1997-07-14 | 2005-11-15 | Osiris Therapeutics Inc | Herzmuskelregenerierung unter verwendung mesenchymaler stammzellen |
| AU729377B2 (en) | 1997-10-23 | 2001-02-01 | Asterias Biotherapeutics, Inc. | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
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| ATE382681T1 (de) | 1998-07-31 | 2008-01-15 | Genzyme Corp | Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen |
| US6667176B1 (en) * | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
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| IL129966A (en) | 1999-05-14 | 2009-12-24 | Technion Res & Dev Foundation | ISOLATED HUMAN EMBRYOID BODIES (hEB) DERIVED FROM HUMAN EMBRYONIC STEM CELLS |
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| EP1221956A2 (en) | 1999-09-30 | 2002-07-17 | McGILL UNIVERSITY | Autologous marrow stem cell (msc) transplantation for myocardial regeneration |
| US6280718B1 (en) | 1999-11-08 | 2001-08-28 | Wisconsin Alumni Reasearch Foundation | Hematopoietic differentiation of human pluripotent embryonic stem cells |
| AU784618B2 (en) | 1999-12-28 | 2006-05-18 | Kyowa Hakko Kogyo Co. Ltd. | Cells capable of differentiating into heart muscle cells |
| US20020142457A1 (en) * | 1999-12-28 | 2002-10-03 | Akihiro Umezawa | Cell having the potentiality of differentiation into cardiomyocytes |
| EP1254211A4 (en) | 2000-01-14 | 2003-07-16 | Bresagen Ltd | PRODUCTION OF CELLS |
| WO2001053465A1 (en) | 2000-01-21 | 2001-07-26 | The Johns Hopkins University School Of Medicine | Human embryoid body-derived cells |
| IL151605A0 (en) | 2000-03-10 | 2003-04-10 | Advanced Res & Tech Inst | Cardiomyocyte cell populations, methods for obtaining the same and devices utilizing the same |
| US20020061587A1 (en) | 2000-07-31 | 2002-05-23 | Piero Anversa | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| EP1315510A4 (en) | 2000-07-31 | 2005-08-03 | New York Medical College | METHODS AND COMPOSITIONS FOR THE REPAIR AND / OR REGENERATION OF DAMAGED MYOCARDE |
| AU2001286173B2 (en) * | 2000-08-01 | 2007-10-25 | Yissum Research Development Company | Directed differentiation of embryonic cells |
| US6607720B1 (en) | 2000-09-05 | 2003-08-19 | Yong-Fu Xiao | Genetically altered mammalian embryonic stem cells, their living progeny, and their therapeutic application for improving cardiac function after myocardial infarction |
| US6534052B1 (en) | 2000-09-05 | 2003-03-18 | Yong-Fu Xiao | Cardiac function comprising implantation of embryonic stem cell in which differentiation has been initiated |
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| US7569222B2 (en) * | 2002-11-18 | 2009-08-04 | Woerly Stephane | Hydrogel membrane composition and use thereof |
| US20050031598A1 (en) | 2002-12-10 | 2005-02-10 | Shulamit Levenberg | Engineering three-dimensional tissue structures using differentiating embryonic stem cells |
| AU2003901099A0 (en) | 2003-03-11 | 2003-03-27 | Es Cell International Pte Ltd. | Methods of inducing differentiation of stem cells |
| US20030224411A1 (en) | 2003-03-13 | 2003-12-04 | Stanton Lawrence W. | Genes that are up- or down-regulated during differentiation of human embryonic stem cells |
| US20050266554A1 (en) * | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| US20050142121A1 (en) | 2003-12-24 | 2005-06-30 | Gold Joseph D. | System for improving acceptance of tissue grafts made from embryonic stem cells |
| CA2559854C (en) * | 2004-03-19 | 2014-12-02 | Geron Corporation | Method for making high purity cardiomyocyte preparations suitable for regenerative medicine |
| US20050214938A1 (en) * | 2004-03-26 | 2005-09-29 | Gold Joseph D | Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function |
| US7452718B2 (en) * | 2004-03-26 | 2008-11-18 | Geron Corporation | Direct differentiation method for making cardiomyocytes from human embryonic stem cells |
| US8932620B2 (en) * | 2005-06-17 | 2015-01-13 | Drexel University | Three-dimensional scaffolds for tissue engineering made by processing complex extracts of natural extracellular matrices |
| JP2010530955A (ja) * | 2006-12-29 | 2010-09-16 | ユニヴァーシティ オブ ワシントン | 二重機能性非汚染表面および材料 |
| CA2713754A1 (en) * | 2008-01-30 | 2009-08-13 | Geron Corporation | Synthetic surfaces for culturing cells in chemically defined media |
| JP5792714B2 (ja) * | 2009-05-28 | 2015-10-14 | コーニング インコーポレイテッド | 細胞培養のための膨潤性の合成マイクロキャリア |
-
2006
- 2006-06-20 KR KR1020137021754A patent/KR20130099253A/ko not_active Ceased
- 2006-06-20 US US11/471,916 patent/US9062289B2/en active Active
- 2006-06-20 EP EP06785229.3A patent/EP1910518B1/en not_active Not-in-force
- 2006-06-20 CN CN200680022866.6A patent/CN101228264B/zh not_active Expired - Fee Related
- 2006-06-20 KR KR1020087001452A patent/KR101529317B1/ko not_active Expired - Fee Related
- 2006-06-20 CA CA2611809A patent/CA2611809C/en not_active Expired - Fee Related
- 2006-06-20 WO PCT/US2006/024060 patent/WO2007002136A2/en not_active Ceased
- 2006-06-20 GB GB0800264A patent/GB2441718B/en not_active Expired - Fee Related
- 2006-06-20 AU AU2006262329A patent/AU2006262329B2/en not_active Ceased
- 2006-06-20 JP JP2008518339A patent/JP5560393B2/ja not_active Expired - Fee Related
-
2007
- 2007-11-25 IL IL187611A patent/IL187611A/en not_active IP Right Cessation
-
2013
- 2013-06-28 JP JP2013135917A patent/JP2013215206A/ja active Pending
-
2015
- 2015-06-22 US US14/746,599 patent/US20150284684A1/en not_active Abandoned
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