CN101228264B - 使灵长类多能干细胞分化成心肌细胞系细胞 - Google Patents

使灵长类多能干细胞分化成心肌细胞系细胞 Download PDF

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CN101228264B
CN101228264B CN200680022866.6A CN200680022866A CN101228264B CN 101228264 B CN101228264 B CN 101228264B CN 200680022866 A CN200680022866 A CN 200680022866A CN 101228264 B CN101228264 B CN 101228264B
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cells
bmp
cell
activin
cardiomyocyte
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CN101228264A (zh
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J·D·戈德
M·哈萨尼波
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ASTERIAS BIOTHERAPY CORP
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

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CN200680022866.6A 2005-06-22 2006-06-20 使灵长类多能干细胞分化成心肌细胞系细胞 Expired - Fee Related CN101228264B (zh)

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US69314105P 2005-06-22 2005-06-22
US60/693,141 2005-06-22
PCT/US2006/024060 WO2007002136A2 (en) 2005-06-22 2006-06-20 Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells

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CN101228264A CN101228264A (zh) 2008-07-23
CN101228264B true CN101228264B (zh) 2017-12-26

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US (2) US9062289B2 (cg-RX-API-DMAC7.html)
EP (1) EP1910518B1 (cg-RX-API-DMAC7.html)
JP (2) JP5560393B2 (cg-RX-API-DMAC7.html)
KR (2) KR20130099253A (cg-RX-API-DMAC7.html)
CN (1) CN101228264B (cg-RX-API-DMAC7.html)
AU (1) AU2006262329B2 (cg-RX-API-DMAC7.html)
CA (1) CA2611809C (cg-RX-API-DMAC7.html)
GB (1) GB2441718B (cg-RX-API-DMAC7.html)
IL (1) IL187611A (cg-RX-API-DMAC7.html)
WO (1) WO2007002136A2 (cg-RX-API-DMAC7.html)

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US20070010012A1 (en) 2007-01-11
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