EP1315510A4 - Methods and compositions for the repair and/or regeneration of damaged myocardium - Google Patents

Methods and compositions for the repair and/or regeneration of damaged myocardium

Info

Publication number
EP1315510A4
EP1315510A4 EP01961855A EP01961855A EP1315510A4 EP 1315510 A4 EP1315510 A4 EP 1315510A4 EP 01961855 A EP01961855 A EP 01961855A EP 01961855 A EP01961855 A EP 01961855A EP 1315510 A4 EP1315510 A4 EP 1315510A4
Authority
EP
European Patent Office
Prior art keywords
regeneration
repair
compositions
methods
damaged myocardium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01961855A
Other languages
German (de)
French (fr)
Other versions
EP1315510A2 (en
Inventor
Piero Anversa
Donald Orlic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York Medical College
US Government
Original Assignee
New York Medical College
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Medical College, US Department of Health and Human Services filed Critical New York Medical College
Publication of EP1315510A2 publication Critical patent/EP1315510A2/en
Publication of EP1315510A4 publication Critical patent/EP1315510A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
EP01961855A 2000-07-31 2001-07-31 Methods and compositions for the repair and/or regeneration of damaged myocardium Withdrawn EP1315510A4 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US22190200P 2000-07-31 2000-07-31
US221902P 2000-07-31
US25856400P 2000-12-29 2000-12-29
US258564P 2000-12-29
US25880501P 2001-01-02 2001-01-02
US258805P 2001-01-02
PCT/US2001/024223 WO2002013760A2 (en) 2000-07-31 2001-07-31 Methods and compositions for the repair and/or regeneration of damaged myocardium

Publications (2)

Publication Number Publication Date
EP1315510A2 EP1315510A2 (en) 2003-06-04
EP1315510A4 true EP1315510A4 (en) 2005-08-03

Family

ID=27397004

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01961855A Withdrawn EP1315510A4 (en) 2000-07-31 2001-07-31 Methods and compositions for the repair and/or regeneration of damaged myocardium

Country Status (4)

Country Link
EP (1) EP1315510A4 (en)
AU (1) AU2001283088A1 (en)
CA (1) CA2423592A1 (en)
WO (1) WO2002013760A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7425448B2 (en) 2001-07-12 2008-09-16 Geron Corporation Cardiomyocyte precursors from human embryonic stem cells
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
WO2004011012A2 (en) 2002-07-29 2004-02-05 Asahi Kasei Kabushiki Kaisha Stem cells for treating pancreatic damage
ITRM20030376A1 (en) 2003-07-31 2005-02-01 Univ Roma PROCEDURE FOR THE ISOLATION AND EXPANSION OF CARDIOC STAMIN CELLS FROM BIOPSIA.
US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
CN101228264B (en) 2005-06-22 2017-12-26 阿斯特利亚斯生物治疗股份公司 PPS is set to be divided into cardiomyocyte-lineage cells
US20110076255A1 (en) 2005-11-07 2011-03-31 Pecora Andrew L Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency
US8637005B2 (en) 2005-11-07 2014-01-28 Amorcyte, Inc. Compositions and methods of vascular injury repair
PT1951864E (en) 2005-11-07 2014-08-27 Amorcyte Inc Compositions and methods of vascular injury repair
US8119123B2 (en) 2006-02-16 2012-02-21 New York Medical College Compositions comprising vascular and myocyte progenitor cells and methods of their use
WO2008011094A2 (en) * 2006-07-18 2008-01-24 Robert Sackstein Cytokine induction of selectin ligands on cells
EP2245140A2 (en) * 2007-11-30 2010-11-03 New York Medical College Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure
US8512696B2 (en) 2007-11-30 2013-08-20 Autologous, Llc Methods of isolating non-senescent cardiac stem cells and uses thereof
WO2009073594A1 (en) 2007-11-30 2009-06-11 New York Medical College Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells
KR101809863B1 (en) 2008-01-30 2017-12-15 아스테리아스 바이오세라퓨틱스, 인크. Synthetic surfaces for culturing stem cell derived cardiomyocytes
JP5705127B2 (en) 2008-12-03 2015-04-22 アモーサイト インコーポレイテッド Infarct region perfusion improving composition and method of repairing vascular injury
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
EP2861238A4 (en) 2012-06-05 2016-03-16 Capricor Inc Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
US9828603B2 (en) 2012-08-13 2017-11-28 Cedars Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
WO2016054591A1 (en) 2014-10-03 2016-04-07 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
US11253551B2 (en) 2016-01-11 2022-02-22 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
EP3515459A4 (en) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
WO2018195210A1 (en) 2017-04-19 2018-10-25 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
EP3727351A4 (en) 2017-12-20 2021-10-06 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018486A1 (en) * 1996-10-25 1998-05-07 Icogen Corporation Use of leptin to stimulate hematopoiesis
WO2000006701A1 (en) * 1998-07-31 2000-02-10 Genzyme Corporation Improvement of cardiac function by mesenchymal stem cell transplantation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018486A1 (en) * 1996-10-25 1998-05-07 Icogen Corporation Use of leptin to stimulate hematopoiesis
WO2000006701A1 (en) * 1998-07-31 2000-02-10 Genzyme Corporation Improvement of cardiac function by mesenchymal stem cell transplantation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
TOMITA S ET AL: "AUTOLOGOUS TRANSPLANTATION OF BONE MARROW CELLS IMPROVES DAMAGED HEART FUNCTION", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 110, no. SUPPL 19, 9 November 1999 (1999-11-09), pages II - 247, XP000869909, ISSN: 0009-7322 *
TOMITA S ET AL: "AUTOTRANSPLANTED MESENCHYMAL STEM CELLS IMPROVE FUNCTION AFTER A MYOCARDIAL INFARCTION", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 98, no. 17, SUPPL, 27 October 1998 (1998-10-27), pages I - 200, XP009032355, ISSN: 0009-7322 *

Also Published As

Publication number Publication date
WO2002013760A3 (en) 2002-04-18
CA2423592A1 (en) 2002-02-21
WO2002013760A2 (en) 2002-02-21
WO2002013760A9 (en) 2003-09-04
EP1315510A2 (en) 2003-06-04
AU2001283088A1 (en) 2002-02-25

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20030226

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS

Owner name: NEW YORK MEDICAL COLLEGE

A4 Supplementary search report drawn up and despatched

Effective date: 20050616

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61P 9/10 B

Ipc: 7A 61K 35/28 A

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20060301