JP2013532492A5 - - Google Patents
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- JP2013532492A5 JP2013532492A5 JP2013523366A JP2013523366A JP2013532492A5 JP 2013532492 A5 JP2013532492 A5 JP 2013532492A5 JP 2013523366 A JP2013523366 A JP 2013523366A JP 2013523366 A JP2013523366 A JP 2013523366A JP 2013532492 A5 JP2013532492 A5 JP 2013532492A5
- Authority
- JP
- Japan
- Prior art keywords
- albumin
- pluripotent stem
- free medium
- cells
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 26
- 239000002609 medium Substances 0.000 claims 24
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 18
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 15
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 10
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 10
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 10
- 102000004877 Insulin Human genes 0.000 claims 9
- 108090001061 Insulin Proteins 0.000 claims 9
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 9
- 102000004338 Transferrin Human genes 0.000 claims 9
- 108090000901 Transferrin Proteins 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 9
- 229940125396 insulin Drugs 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 229910052711 selenium Inorganic materials 0.000 claims 9
- 239000011669 selenium Substances 0.000 claims 9
- 239000012581 transferrin Substances 0.000 claims 9
- 229940088594 vitamin Drugs 0.000 claims 9
- 229930003231 vitamin Natural products 0.000 claims 9
- 235000013343 vitamin Nutrition 0.000 claims 9
- 239000011782 vitamin Substances 0.000 claims 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 8
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 8
- 239000008103 glucose Substances 0.000 claims 8
- 230000008672 reprogramming Effects 0.000 claims 7
- 229960001031 glucose Drugs 0.000 claims 6
- 229940024606 amino acid Drugs 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 239000011435 rock Substances 0.000 claims 5
- 238000010367 cloning Methods 0.000 claims 4
- 210000001082 somatic cell Anatomy 0.000 claims 4
- 230000010261 cell growth Effects 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- LZAXPYOBKSJSEX-UHFFFAOYSA-N blebbistatin Chemical compound C1CC2(O)C(=O)C3=CC(C)=CC=C3N=C2N1C1=CC=CC=C1 LZAXPYOBKSJSEX-UHFFFAOYSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 102100035140 Vitronectin Human genes 0.000 claims 1
- 108010031318 Vitronectin Proteins 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 229960000890 hydrocortisone Drugs 0.000 claims 1
- 230000001146 hypoxic effect Effects 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 238000007747 plating Methods 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37112810P | 2010-08-05 | 2010-08-05 | |
| US61/371,128 | 2010-08-05 | ||
| PCT/US2011/046796 WO2012019122A2 (en) | 2010-08-05 | 2011-08-05 | Simplified basic media for human pluripotent cell culture |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016186896A Division JP2017018137A (ja) | 2010-08-05 | 2016-09-26 | ヒト多能性細胞培養のための簡易基本培地 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532492A JP2013532492A (ja) | 2013-08-19 |
| JP2013532492A5 true JP2013532492A5 (cg-RX-API-DMAC7.html) | 2014-09-25 |
| JP6043999B2 JP6043999B2 (ja) | 2016-12-14 |
Family
ID=44543813
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523366A Active JP6043999B2 (ja) | 2010-08-05 | 2011-08-05 | ヒト多能性細胞培養のための簡易基本培地 |
| JP2016186896A Pending JP2017018137A (ja) | 2010-08-05 | 2016-09-26 | ヒト多能性細胞培養のための簡易基本培地 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016186896A Pending JP2017018137A (ja) | 2010-08-05 | 2016-09-26 | ヒト多能性細胞培養のための簡易基本培地 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9279103B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2601288B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6043999B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101829488B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN108531444A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2011285531B2 (cg-RX-API-DMAC7.html) |
| BR (2) | BR122020000909B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2807418C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2601288T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL224431A (cg-RX-API-DMAC7.html) |
| SG (1) | SG187699A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012019122A2 (cg-RX-API-DMAC7.html) |
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| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| CA2695225C (en) | 2007-07-31 | 2021-06-01 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| CA2954431C (en) | 2007-11-27 | 2021-08-24 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
| CN102046779A (zh) | 2008-02-21 | 2011-05-04 | 森托科尔奥索生物科技公司 | 用于细胞粘附、培养和分离的方法、表面改性培养板和组合物 |
| EP2942392B1 (en) | 2008-06-30 | 2018-10-03 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| ES2727950T3 (es) | 2008-10-31 | 2019-10-21 | Janssen Biotech Inc | Diferenciación de células madre embrionarias humanas en linaje endocrino pancreático |
| MX2011004565A (es) | 2008-10-31 | 2011-07-28 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico. |
| JP5719305B2 (ja) | 2008-11-20 | 2015-05-13 | ヤンセン バイオテツク，インコーポレーテツド | 平面支持体上での細胞付着及び培養のための方法及び組成物 |
| KR101774546B1 (ko) | 2008-11-20 | 2017-09-04 | 얀센 바이오테크 인코포레이티드 | 마이크로-캐리어 상의 만능 줄기 세포 배양 |
| BR112012001480A2 (pt) | 2009-07-20 | 2015-09-01 | Janssen Biotech Inc | Diferenciação de células-tronco embriônicas humanas |
| MX343786B (es) | 2009-12-23 | 2016-11-22 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionarias humanas. |
| SG10201501503VA (en) | 2010-03-01 | 2015-04-29 | Janssen Biotech Inc | Methods for purifying cells derived from pluripotent stem cells |
| EP3498825A1 (en) | 2010-05-12 | 2019-06-19 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| US9279107B2 (en) | 2010-08-05 | 2016-03-08 | Wisconsin Alumni Research Foundation | Simplified basic media for human pluripotent cell culture |
| ES2585028T3 (es) | 2010-08-31 | 2016-10-03 | Janssen Biotech, Inc. | Diferenciación de células madre pluripotentes |
| EP3211070A1 (en) | 2010-08-31 | 2017-08-30 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| CA2809300A1 (en) | 2010-08-31 | 2012-03-08 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| CA2858148C (en) | 2011-12-05 | 2023-03-14 | Factor Bioscience Inc. | Methods and products for transfecting cells |
| WO2013090919A1 (en) | 2011-12-16 | 2013-06-20 | Wisconsin Alumni Research Foundation | Fgf-2 having enhanced stability |
| MX2014007744A (es) | 2011-12-22 | 2015-01-12 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionicas humanas en celulas individuales positivas de insulina hormonal. |
| MX354775B (es) | 2012-03-07 | 2018-03-20 | Janssen Biotech Inc | Medios definidos para la expansion y el mantenimiento de celulas madre pluripotentes. |
| DK3450542T3 (da) | 2012-06-08 | 2021-11-01 | Janssen Biotech Inc | Differentiering af humane embryonale stamceller til endokrine pancreatiske celler |
| CA2890110C (en) | 2012-11-01 | 2023-05-02 | Factor Bioscience Inc. | Methods and products for expressing proteins in cells |
| ES2942484T3 (es) | 2012-12-31 | 2023-06-01 | Janssen Biotech Inc | Diferenciación de células madre embrionarias humanas en células endocrinas pancreáticas usando reguladores de HB9 |
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| KR102211266B1 (ko) | 2013-01-31 | 2021-02-04 | 아지노모토 가부시키가이샤 | 다능성 줄기 세포의 안정한 미분화 유지 증식을 실시하기 위한 배양 방법 |
| WO2014208295A1 (ja) | 2013-06-28 | 2014-12-31 | 株式会社カネカ | 多能性幹細胞の増殖促進因子のスクリーニング法 |
| WO2015006762A1 (en) * | 2013-07-12 | 2015-01-15 | The Board Of Trustees Of The University Of Arkansas | Methods and compositions for expanding long-term hematopoietic stem cell populations |
| KR101655383B1 (ko) * | 2013-07-27 | 2016-09-08 | 고려대학교 산학협력단 | 소분자 화합물을 포함하는 만능성 줄기세포의 염색체 안정성 유지용 조성물 |
| US20160230143A1 (en) | 2013-09-19 | 2016-08-11 | The U.S.A., As Represented By The Secretary, Department Of Health & Human Services | Chemically defined culture medium for stem cell maintenance and differentiation |
| RU2714404C2 (ru) | 2014-01-31 | 2020-02-14 | Фэктор Байосайенс Инк. | Способы и продукты для получения и доставки нуклеиновых кислот |
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| EP3177302A4 (en) * | 2014-08-07 | 2018-04-11 | Duke University | Compositions and methods for the reprogramming of cells into cardiomyocytes |
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| JP6800859B2 (ja) | 2015-01-26 | 2020-12-16 | フェイト セラピューティクス，インコーポレイテッド | 造血細胞分化を誘導するための方法および組成物 |
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| EP3371314B1 (en) | 2015-11-04 | 2023-07-05 | Fate Therapeutics, Inc. | Genomic engineering of pluripotent cells |
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| KR101953573B1 (ko) * | 2017-03-31 | 2019-03-05 | 한양대학교 에리카산학협력단 | 난황줄기세포 배양을 위한 우태아혈청 조성물 및 이의 제조방법 |
| KR102668891B1 (ko) | 2017-04-18 | 2024-05-29 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 항원-특이적 면역 이펙터 세포 |
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| KR102121602B1 (ko) * | 2018-06-27 | 2020-06-10 | 주식회사 티아라줄기세포연구소 | 지방줄기세포배양용 배지 조성물 제조방법, 지방줄기세포배양용 배지 조성물 제조방법과 줄기세포 유효성분 3저 추출법을 이용한 줄기세포파쇄추출물(쉘드줄기세포) 제조방법, 이를 이용한 항관절염 치료용 조성물, 이를 이용한 염증억제 효과를 갖는 조성물 및 세포재생 효과를 갖는 조성물 |
| WO2020200071A1 (en) * | 2019-04-05 | 2020-10-08 | The University Of Hong Kong | Culture medium for mammalian expanded potential stem cells, composition, and methods thereof |
| CN119569589A (zh) | 2019-07-03 | 2025-03-07 | 菲克特生物科学股份有限公司 | 阳离子脂质及其用途 |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| AU2020351221A1 (en) * | 2019-09-19 | 2022-05-05 | Northwestern University | Cost effective culture media and protocol for human induced pluripotent stem cells |
| CN110564673A (zh) * | 2019-09-26 | 2019-12-13 | 广东工业大学 | 一种干细胞培养液及其应用 |
| CN110564678B (zh) * | 2019-10-12 | 2023-04-07 | 广东唯泰生物科技有限公司 | 脐带华通氏胶间充质干细胞成骨定向分化的方法 |
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| WO2009135206A1 (en) | 2008-05-02 | 2009-11-05 | Stem Cell Products, Inc. | Method for production of mast cells from stem cells |
| US8268620B2 (en) | 2008-10-24 | 2012-09-18 | Wisconsin Alumni Research Foundation | OCT4 and SOX2 with SV40 T antigen produce pluripotent stem cells from primate somatic cells |
| EP3633025B1 (en) * | 2009-11-12 | 2022-09-14 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
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2011
- 2011-08-05 CN CN201810229027.6A patent/CN108531444A/zh active Pending
- 2011-08-05 BR BR122020000909-8A patent/BR122020000909B1/pt active IP Right Grant
- 2011-08-05 BR BR112013002811A patent/BR112013002811A8/pt not_active Application Discontinuation
- 2011-08-05 EP EP11751704.5A patent/EP2601288B1/en active Active
- 2011-08-05 AU AU2011285531A patent/AU2011285531B2/en active Active
- 2011-08-05 SG SG2013008347A patent/SG187699A1/en unknown
- 2011-08-05 US US13/204,354 patent/US9279103B2/en active Active
- 2011-08-05 WO PCT/US2011/046796 patent/WO2012019122A2/en not_active Ceased
- 2011-08-05 KR KR1020137005512A patent/KR101829488B1/ko active Active
- 2011-08-05 CN CN2011800385969A patent/CN103180434A/zh active Pending
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2016
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