JP2008542311A5 - - Google Patents

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Publication number
JP2008542311A5
JP2008542311A5 JP2008513928A JP2008513928A JP2008542311A5 JP 2008542311 A5 JP2008542311 A5 JP 2008542311A5 JP 2008513928 A JP2008513928 A JP 2008513928A JP 2008513928 A JP2008513928 A JP 2008513928A JP 2008542311 A5 JP2008542311 A5 JP 2008542311A5
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JP
Japan
Prior art keywords
peg
polypeptide
csf
regioisomers
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2008513928A
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English (en)
Japanese (ja)
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JP2008542311A (ja
JP5137821B2 (ja
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Priority claimed from PCT/DK2006/000292 external-priority patent/WO2006128460A2/en
Publication of JP2008542311A publication Critical patent/JP2008542311A/ja
Publication of JP2008542311A5 publication Critical patent/JP2008542311A5/ja
Application granted granted Critical
Publication of JP5137821B2 publication Critical patent/JP5137821B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2008513928A 2005-06-01 2006-05-26 Ｐｅｇ化されたｇ−ｃｓｆポリペプチドおよびその製造方法 Expired - Fee Related JP5137821B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68672605P 2005-06-01 2005-06-01
US60/686,726 2005-06-01
PCT/DK2006/000292 WO2006128460A2 (en) 2005-06-01 2006-05-26 Pegylated g-csf polypeptides and methods of producing same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012173959A Division JP2013010765A (ja) 2005-06-01 2012-08-06 Ｐｅｇ化されたｇ−ｃｓｆポリペプチドおよびその製造方法

Publications (3)

Publication Number Publication Date
JP2008542311A JP2008542311A (ja) 2008-11-27
JP2008542311A5 true JP2008542311A5 (enExample) 2009-01-15
JP5137821B2 JP5137821B2 (ja) 2013-02-06

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ID=37308965

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008513928A Expired - Fee Related JP5137821B2 (ja) 2005-06-01 2006-05-26 Ｐｅｇ化されたｇ−ｃｓｆポリペプチドおよびその製造方法
JP2012173959A Pending JP2013010765A (ja) 2005-06-01 2012-08-06 Ｐｅｇ化されたｇ−ｃｓｆポリペプチドおよびその製造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012173959A Pending JP2013010765A (ja) 2005-06-01 2012-08-06 Ｐｅｇ化されたｇ−ｃｓｆポリペプチドおよびその製造方法

Country Status (16)

Country Link
US (5) US7381805B2 (enExample)
EP (1) EP1888119B1 (enExample)
JP (2) JP5137821B2 (enExample)
KR (1) KR20080027291A (enExample)
CN (1) CN101193658B (enExample)
AT (1) ATE500847T1 (enExample)
AU (1) AU2006254543A1 (enExample)
BR (1) BRPI0611221A2 (enExample)
CA (1) CA2607844C (enExample)
DE (1) DE602006020562D1 (enExample)
IL (1) IL187009A0 (enExample)
MX (1) MX2007015156A (enExample)
NO (1) NO20075708L (enExample)
RU (1) RU2007149238A (enExample)
WO (1) WO2006128460A2 (enExample)
ZA (1) ZA200709704B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2007149238A (ru) 2005-06-01 2009-07-20 Максиджен Холдингз Лтд. (Ky) Пегилированные полипептиды гксф и способы их получения
BRPI0815975B8 (pt) * 2007-08-27 2021-05-25 Biogenerix Ag preparação aquosa, recipiente farmacêutico, processo para preparar uma preparação aquosa, e, uso de uma preparação aquosa
EP2344203A2 (en) * 2008-09-19 2011-07-20 Maxygen, Inc. Method for the treatment of radiation-induced neutropenia by administration of a multi-pegylated granulocyte colony stimulating factor (g-csf) variant
US7914828B2 (en) * 2008-10-17 2011-03-29 Levine Brian M Combination herbal product to benefit respiratory tract
WO2011041376A1 (en) * 2009-09-30 2011-04-07 Prolong Pharmaceuticals Modified granulocyte colony stimulating factor (g-csf)
EP2494050A4 (en) * 2009-10-30 2013-10-30 Merck Sharp & Dohme GRANULOCYTIC COLONY STIMULATING FACTOR MADE IN GLYCOENGINEERED PICHIA PASTORIS
AR083006A1 (es) * 2010-09-23 2013-01-23 Lilly Co Eli Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
WO2012064845A2 (en) * 2010-11-09 2012-05-18 Nektar Therapeutics G-csf polymer conjugates having a releasable linkage
US20140187488A1 (en) * 2011-05-17 2014-07-03 Bristol-Myers Squibb Company Methods for maintaining pegylation of polypeptides
CN104109199B (zh) * 2013-04-16 2019-04-30 深圳未名新鹏生物医药有限公司 一种聚乙二醇单修饰的人粒细胞集落刺激因子的制备方法及其产品
AU2016277147A1 (en) * 2015-06-11 2018-01-18 Ambio Pharmaceuticals, Llc Pegylated granulocyte colony stimulating factor (GCSF)
KR102020995B1 (ko) * 2017-10-30 2019-09-16 한국코러스 주식회사 콜로니자극인자와 폴리올이 접합된 접합물을 고수율로 제조하는 방법
US20210386680A1 (en) * 2018-12-06 2021-12-16 Board Of Regents, The University Of Texas System Selectively cleavable therapeutic nanoparticles
CN114853872B (zh) * 2022-04-27 2023-11-17 山东新时代药业有限公司 一种聚乙二醇修饰rhG-CSF的制备方法

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US588025A (en) * 1897-08-10 Furnace-door-operating device
AU631312B (en) 1912-09-04 1913-09-16 Aage Philip Heyman Improvements in and relating; to milking; machines
WO1985000817A1 (en) 1983-08-10 1985-02-28 Amgen Microbial expression of interleukin ii
JPS61227526A (ja) 1984-07-25 1986-10-09 Chugai Pharmaceut Co Ltd 新規なコロニー刺激因子
ATE65798T1 (de) 1985-02-08 1991-08-15 Chugai Pharmaceutical Co Ltd Menschlicher granuloxcyt-koloniestimulierungsfaktor.
US6004548A (en) 1985-08-23 1999-12-21 Amgen, Inc. Analogs of pluripotent granulocyte colony-stimulating factor
JPS63500636A (ja) 1985-08-23 1988-03-10 麒麟麦酒株式会社 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ
US4810643A (en) 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPS6263335A (ja) 1985-09-13 1987-03-20 Fuji Photo Film Co Ltd 化学反応情報の処理方法
DE3681551D1 (de) 1985-09-30 1991-10-24 Chugai Pharmaceutical Co Ltd Menschlicher granulozyten-colony stimulierender faktor.
ATE65403T1 (de) 1986-01-22 1991-08-15 Chugai Pharmaceutical Co Ltd Pharmazeutischer stoff fuer die foerderung der wiederherstellung der haematopoietischen faehigkeit.
US4908773A (en) 1987-04-06 1990-03-13 Genex Corporation Computer designed stabilized proteins and method for producing same
DK203187A (da) 1986-04-22 1987-10-23 Immunex Corp Human g-csf proteinekspression
EP0256843A1 (en) 1986-08-11 1988-02-24 Cetus Corporation Expression of g-csf and muteins thereof and their use
US4704692A (en) 1986-09-02 1987-11-03 Ladner Robert C Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
NO176799C (no) 1986-12-23 1995-05-31 Kyowa Hakko Kogyo Kk DNA som koder for et polypeptid, rekombinant plasmid som koder for og kan uttrykke et polypeptid og fremgangsmåte for fremstilling av dette polypeptid
US5214132A (en) 1986-12-23 1993-05-25 Kyowa Hakko Kogyo Co., Ltd. Polypeptide derivatives of human granulocyte colony stimulating factor
US5362853A (en) 1986-12-23 1994-11-08 Kyowa Hakko Kogyo Co., Ltd. Polypeptide derivatives of human granulocyte colony stimulating factor
US5714581A (en) 1986-12-23 1998-02-03 Kyowa Hakko Kogyo Co., Ltd. Polypeptide derivatives of human granulocyte colony stimulating factor
US4853871A (en) 1987-04-06 1989-08-01 Genex Corporation Computer-based method for designing stablized proteins
US4904584A (en) 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
GB2213821B (en) 1987-12-23 1992-01-02 British Bio Technology Synthetic human granulocyte colony stimulating factor gene
CA1340810C (en) 1988-03-31 1999-11-02 Motoo Yamasaki Polypeptide derivatives of human granulocyte colony stimulating factor
WO1989010932A1 (en) 1988-05-13 1989-11-16 Amgen Inc. Compositions and method for treating or preventing infections in animals
EP0344796B1 (en) 1988-06-03 1994-09-21 Chugai Seiyaku Kabushiki Kaisha Crystalline human granulocyte colony stimulating factor and process for preparing the same
US5025388A (en) 1988-08-26 1991-06-18 Cramer Richard D Iii Comparative molecular field analysis (CoMFA)
US5218092A (en) 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
US5349052A (en) 1988-10-20 1994-09-20 Royal Free Hospital School Of Medicine Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor
US5104651A (en) 1988-12-16 1992-04-14 Amgen Inc. Stabilized hydrophobic protein formulations of g-csf
US20020177688A1 (en) * 1988-12-22 2002-11-28 Kirin-Amgen, Inc., Chemically-modified G-CSF
US6166183A (en) 1992-11-30 2000-12-26 Kirin-Amgen, Inc. Chemically-modified G-CSF
JP2989002B2 (ja) * 1988-12-22 1999-12-13 キリン―アムジエン・インコーポレーテツド 化学修飾顆粒球コロニー刺激因子
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5109119A (en) 1989-06-06 1992-04-28 Schering Corporation Crystalline r-h-gm-csf and method
IE66494B1 (en) 1989-09-26 1996-01-10 Immunex Corp Granulocyte-colony stimulating factor receptors
EP0648501A1 (en) 1989-10-10 1995-04-19 Amgen Inc. Compositions comprising G-CSF for treating or preventing infections in canine and feline animals
US5265030A (en) 1990-04-24 1993-11-23 Scripps Clinic And Research Foundation System and method for determining three-dimensional structures of proteins
GB9107846D0 (en) 1990-04-30 1991-05-29 Ici Plc Polypeptides
DE4014750A1 (de) 1990-05-08 1991-11-14 Boehringer Mannheim Gmbh Muteine des granulozyten-stimulierenden faktors (g-csf)
US5399345A (en) 1990-05-08 1995-03-21 Boehringer Mannheim, Gmbh Muteins of the granulocyte colony stimulating factor
JP3249147B2 (ja) 1990-06-01 2002-01-21 キリン−アムジエン・インコーポレーテツド 生理活性蛋白含有経口製剤
IE912365A1 (en) 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
ATE167896T1 (de) 1990-08-29 1998-07-15 Genetics Inst Aus mehreren domänen bestehende hämatopoese- stimulatoren
US5124297A (en) 1990-12-07 1992-06-23 Amoco Corporation Olefin polymerization and copolymerization catalyst
DE4105480A1 (de) 1991-02-21 1992-08-27 Boehringer Mannheim Gmbh Verbesserte aktivierung von rekombinanten proteinen
US6565841B1 (en) 1991-03-15 2003-05-20 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
US5157736A (en) 1991-04-19 1992-10-20 International Business Machines Corporation Apparatus and method for optical recognition of chemical graphics
WO1992021029A1 (en) 1991-05-10 1992-11-26 Genentech, Inc. Selecting ligand agonists and antagonists
US5386507A (en) 1991-07-18 1995-01-31 Teig; Steven L. Computer graphics system for selectively modelling molecules and investigating the chemical and physical properties thereof
US5281698A (en) 1991-07-23 1994-01-25 Cetus Oncology Corporation Preparation of an activated polymer ester for protein conjugation
JPH06510202A (ja) 1991-08-30 1994-11-17 フレッド・ハッチンソン・キャンサー・リサーチ・センター ハイブリッドサイトカイン
JP2638359B2 (ja) 1991-11-26 1997-08-06 富士通株式会社 分子動力学法の拘束条件作成装置
US5866114A (en) 1992-06-09 1999-02-02 Chiron Corporation Crystallization of M-CSFα
ZA933926B (en) 1992-06-17 1994-01-03 Amgen Inc Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules
US5738849A (en) 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
PT672145E (pt) 1992-11-24 2003-08-29 Searle & Co Polipeptideos de interleucina-3(il-3) com multiplas mutacoes
US5772992A (en) 1992-11-24 1998-06-30 G.D. Searle & Co. Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
US6153183A (en) 1992-11-24 2000-11-28 G. D. Searle & Company Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production
US6057133A (en) 1992-11-24 2000-05-02 G. D. Searle Multivariant human IL-3 fusion proteins and their recombinant production
US5424963A (en) 1992-11-25 1995-06-13 Photon Research Associates, Inc. Molecular dynamics simulation method and apparatus
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
AU1916295A (en) 1994-02-08 1995-08-29 Amgen, Inc. Oral delivery of chemically modified proteins
CA2183871C (en) 1994-02-23 2008-11-04 Motoo Yamasaki Platelet growth accelerator
US5635599A (en) 1994-04-08 1997-06-03 The United States Of America As Represented By The Department Of Health And Human Services Fusion proteins comprising circularly permuted ligands
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
WO1996023888A1 (en) 1995-02-03 1996-08-08 G.D. Searle & Co. NOVEL c-MPL LIGANDS
US6017523A (en) 1995-06-06 2000-01-25 G.D. Searle & Co. Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides
JPH11510062A (ja) 1995-10-05 1999-09-07 ジー．ディー．サール アンド カンパニー 多機能性造血受容体アゴニスト
JP2000513924A (ja) 1995-10-05 2000-10-24 ジー．ディー．サール アンド カンパニー 新規ｃ−ｍｐｌ受容体アゴニスト
US6066318A (en) 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6100070A (en) 1995-10-05 2000-08-08 G. D. Searle & Co. G-CSF receptor agonists
AU717733B2 (en) 1995-10-05 2000-03-30 G.D. Searle & Co. Novel G-CSF receptor agonists
CZ295843B6 (cs) 1996-10-25 2005-11-16 G. D. Searle & Co. Multi-funkční chimérní agonisté hematopoietických receptorů
US6660257B1 (en) 1996-10-25 2003-12-09 Pharmacia Corporation Circular permuteins of flt3 ligand
US5969105A (en) 1996-10-25 1999-10-19 Feng; Yiqing Stem cell factor receptor agonists
WO1998046750A1 (en) 1997-04-11 1998-10-22 G.D. Searle & Co. flt3 LIGAND CHIMERIC PROTEINS
KR100241257B1 (ko) 1997-05-22 2000-02-01 한승수 인체 과립구 콜로니 자극 인자 활성물질 및 그것의 제조방법
EP0921131B1 (en) 1997-06-06 2010-05-26 Kyowa Hakko Kirin Co., Ltd. Chemically modified polypeptides
ES2297889T3 (es) 1997-07-14 2008-05-01 Bolder Biotechnology, Inc. Derivados de hormona de crecimiento y proteinas relacionadas.
US5985263A (en) 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US6451986B1 (en) 1998-06-22 2002-09-17 Immunex Corporation Site specific protein modification
AU6246599A (en) 1998-09-25 2000-04-17 G.D. Searle & Co. Method of producing permuteins by scanning permutagenesis
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
US6627186B1 (en) 1999-01-06 2003-09-30 Xencor Nucleic acids and protein variants of hG-CSF with granulopoietic activity
PT1157037E (pt) 1999-01-29 2003-12-31 Hoffmann La Roche Conjugados de gcsf
JP2000319298A (ja) 1999-03-04 2000-11-21 Seibutsu Bunshi Kogaku Kenkyusho:Kk 蛋白質複合体の結晶、構造座標、及び構造座標の使用
KR100356140B1 (ko) 1999-07-08 2002-10-19 한미약품공업 주식회사 인간 과립구 콜로니 자극인자 변이체 및 이의 생산 방법
US6646110B2 (en) 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
BR0107561A (pt) * 2000-01-10 2002-11-19 Maxygen Holdings Ltd Polipeptìdios ou conjugados entre polipeptìdios que exibem atividade (g-csf), métodos de preparação dos mesmos e seus usos
US6831158B2 (en) 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
US6555660B2 (en) 2000-01-10 2003-04-29 Maxygen Holdings Ltd. G-CSF conjugates
EP1354045A2 (en) 2000-09-07 2003-10-22 Eli Lilly And Company Hyperglycosylated polypeptides
DE60125381T2 (de) 2000-09-08 2007-04-12 Massachusetts Institute Of Technology, Cambridge Zusammensetzungen und verfahren mit analogen von g-csf
GB0022877D0 (en) 2000-09-18 2000-11-01 Isis Innovation Analogues
AU2002212108A1 (en) * 2000-11-02 2002-05-15 Maxygen Aps Single-chain multimeric polypeptides
US20020142964A1 (en) 2000-11-02 2002-10-03 Nissen Torben Lauesgaard Single-chain polypeptides
WO2002048871A1 (en) * 2000-12-11 2002-06-20 Koninklijke Philips Electronics N.V. Signal processing device and method for supplying a signal processing result to a plurality of registers
BR0211071A (pt) * 2001-07-11 2004-12-21 Maxygen Holdings Ltd Conjugado polipeptìdico apresentando atividade de g-csf, método para preparar um conjugado de g-csf, composição, método para tratar um mamìfero sofrendo de um nìvel neutrofìlico insuficiente, e, uso do conjugado polipeptìdico
RU2007149238A (ru) 2005-06-01 2009-07-20 Максиджен Холдингз Лтд. (Ky) Пегилированные полипептиды гксф и способы их получения

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